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1.
Vaccination coverage, hesitancy and associated factors: a household survey of a cohort of children born in 2017 and 2018 in urban areas of state capital cities in the Brazilian Northeast
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Saavedra, Ramon da Costa
; Santiago, Martha Suely Itaparica de Carvalho
; Teixeira, Maria da Glória Lima Cruz
; Antunes, Maria Bernadete de Cerqueira
; Queiroz, Rejane Christine de Sousa
; Lima, Luisa Helena de Oliveira
; Ramos Jr, Alberto Novaes
; Ferreira, Anderson Fuentes
; Maciel, Adjoane Mauricio Silva
; Barbosa, Jaqueline Caracas
; França, Ana Paula
; Domingues, Carla Magda Allan Santos
; Moraes, José Cássio de
; Silva, Adriana Ilha da
; Ramos Jr., Alberto Novaes
; França, Ana Paula
; Oliveira, Andrea de Nazaré Marvão
; Boing, Antonio Fernando
; Domingues, Carla Magda Allan Santos
; Oliveira, Consuelo Silva de
; Maciel, Ethel Leonor Noia
; Guibu, Ione Aquemi
; Mirabal, Isabelle Ribeiro Barbosa
; Barbosa, Jaqueline Caracas
; Lima, Jaqueline Costa
; Moraes, José Cássio de
; Luhm, Karin Regina
; Caetano, Karlla Antonieta Amorim
; Lima, Luisa Helena de Oliveira
; Antunes, Maria Bernadete de Cerqueira
; Teixeira, Maria da Glória Lima Cruz
; Teixeira, Maria Denise de Castro
; Borges, Maria Fernanda de Sousa Oliveira
; Queiroz, Rejane Christine de Sousa
; Gurgel, Ricardo Queiroz
; Barata, Rita Barradas
; Azevedo, Roberta Nogueira Calandrini de
; Oliveira, Sandra Maria do Valle Leone de
; Teles, Sheila Araújo
; Gama, Silvana Granado Nogueira da
; Mengue, Sotero Serrate
; Simões, Taynãna César
; Nascimento, Valdir
; Araújo, Wildo Navegantes de
.












































RESUMO Objetivo Estimar a cobertura vacinal e analisar fatores sociodemográficos associados à não vacinação em crianças nascidas vivas em 2017 e 2018 nas capitais do Nordeste brasileiro. Métodos Realizou-se inquérito domiciliar com amostragem por conglomerados, entre 2020 e 2022, para estimar cobertura e hesitação vacinal. Fatores associados à não vacinação foram analisados usando-se regressão logística para calcular odds ratio (OR) e seus intervalos de confiança (IC95%). Resultados A capital com menores coberturas vacinais foi Natal, com < 75,0% para a maioria dos imunizantes; Teresina apresentou coberturas ≥ 90,0% em todos os imunizantes. Dos entrevistados, 99,1% (IC95% 98,9;99,3) acreditavam que vacinas são importantes para a saúde; 95,4% (IC95% 95,0;95,8) confiavam nos imunobiológicos distribuídos pelo governo; e 79,6% (IC95% 78,8;80,3) não tinham medo de reações adversas. Residir em estrato socioeconômico mais alto (OR ajustado: 1,34 – IC95% 1,20;1,50) foi fator associado à não vacinação. Conclusão As baixas coberturas destacam a necessidade de entender melhor as especificidades regionais e as desigualdades sociais.
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ABSTRACT Objective To estimate vaccination coverage and analyze sociodemographic factors associated with non-vaccination in children born in 2017 and 2018 in the state capitals of Northeast Brazil. Methods A household survey using cluster sampling was conducted from 2020-2022 to estimate vaccination coverage and hesitancy. Factors associated with non-vaccination were analyzed using logistic regression to calculate Odds Ratios (OR) and their Confidence Intervals (95%CI). Results Natal was the capital with the lowest vaccination coverage, below 75.0% for most immunizers. Teresina had rates equal to or greater than 90.0% for all vaccines. Among those interviewed, 99.1% (95%CI 98.9;99.3) believe that vaccines are important for health; 95.4% (95%CI 95.0;95.8) trust immunobiologicals and 79.6% (95%CI% 78.8;80.3) are not afraid of reactions. Belonging to the highest socioeconomic stratum (adjusted OR: 1.34 – 95%CI 1.20;1.50) was as a factor associated with non-vaccination. Conclusion Low coverage highlights the need for a better understanding of regional specificities and social inequalities.
2.
Measles, mumps and rubella vaccination coverage in capitals and interior region municipalities of Northeast Brazil: a household survey in a cohort of children born in 2017 and 2018
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Maciel, Adjoane Mauricio Silva
; Ramos Jr, Alberto Novaes
; Ferreira, Anderson Fuentes
; Silva, Taynara Lais
; Domingues, Carla Magda Allan Santos
; Saavedra, Ramon da Costa
; Barbosa, Jaqueline Caracas
; França, Ana Paula
; Kerr, Ligia Regina Franco Sansigolo
; Teixeira, Maria da Gloria
; Moraes, José Cássio de
; Silva, Adriana Ilha da
; Ramos Jr., Alberto Novaes
; França, Ana Paula
; Oliveira, Andrea de Nazaré Marvão
; Boing, Antonio Fernando
; Domingues, Carla Magda Allan Santos
; Oliveira, Consuelo Silva de
; Maciel, Ethel Leonor Noia
; Guibu, Ione Aquemi
; Mirabal, Isabelle Ribeiro Barbosa
; Barbosa, Jaqueline Caracas
; Lima, Jaqueline Costa
; Moraes, José Cássio de
; Luhm, Karin Regina
; Caetano, Karlla Antonieta Amorim
; Lima, Luisa Helena de Oliveira
; Antunes, Maria Bernadete de Cerqueira
; Teixeira, Maria da Gloria
; Teixeira, Maria Denise de Castro
; Borges, Maria Fernanda de Sousa Oliveira
; Queiroz, Rejane Christine de Sousa
; Gurgel, Ricardo Queiroz
; Barata, Rita Barradas
; Azevedo, Roberta Nogueira Calandrini de
; Oliveira, Sandra Maria do Valle Leone de
; Teles, Sheila Araújo
; Gama, Silvana Granado Nogueira da
; Mengue, Sotero Serrate
; Simões, Taynãna César
; Nascimento, Valdir
; Araújo, Wildo Navegantes de
.










































RESUMO Objetivo Analisar a cobertura vacinal contra sarampo, caxumba e rubéola em crianças até 24 meses de idade e os fatores associados à não vacinação em coorte de nascidos-vivos em 2017-2018, em capitais e municípios de grande porte populacional do interior do Nordeste brasileiro. Métodos Inquérito domiciliar populacional com análise de cobertura vacinal e fatores sociodemográficos por regressão logística. Resultados Em 12.137 crianças, cobertura vacinal de 79,3% (IC95% 76,5;81,8) e taxa de abandono de 10,6%. Associação à não vacinação: estrato socioeconômico A (OR-a 1,29; IC95% 1,10;1,50), residir no interior (OR-a 1,22; IC95% 1,07;1,39), não acesso ao Programa Bolsa Família (OR-a 1,19; IC95% 1,05;1,34), renda familiar ≤ R$ 1.000,00 (OR-a 1,17; IC95% 1,03;1,31), mãe sem trabalho remunerado (OR-a 1,28; IC95% 1,15;1,42), > 1 filho por mãe (OR-a 1,12; IC95% 1,08;1,17), sem caderneta de vacinação (OR-a 10,69; IC95% 6,27;18,20). Conclusão Baixa cobertura e alta taxa de abandono vacinal em capitais e municípios do interior do Nordeste.
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ABSTRACT Objective To analyze measles, mumps, and rubella vaccination coverage among children up to 24 months old and factors associated with non-vaccination in a 2017−2018 live birth cohort, in state capitals and large interior region cities in Northeast Brazil. Methods Population-based survey analyzing vaccination coverage and sociodemographic factors through logistic regression. Results For 12,137 children, vaccination coverage was 79.3% (95%CI 76.5;81.8), and the dropout rate was 10.6%. Association with non-vaccination: socioeconomic stratum A (OR-a 1.29; 95%CI 1.10;1.50), living in the interior region (OR-a 1.22; 95%CI 1.07;1.39), no access to the Bolsa Família Program (OR-a 1.19, 95%CI 1.05;1.34), family income ≤BRL 1,000 (OR-a 1.17, 95%CI 1.03;1.31), mother not working (OR-a 1.28, 95%CI 1.15;1.42), >1 child per mother (OR-a 1.12, 95%CI 1.08;1.17), and no vaccination card (OR-a 10.69, 95%CI 6.27;18.20). Conclusion Low vaccination coverage and a high dropout rate in state capitals and municipalities in the interior region of Northeast Brazil.
3.
Vaccination coverage, vaccine hesitancy and factors associated with incomplete vaccination: a household survey conducted with children born between 2017 and 2018 in the inland municipalities of Northeastern Brazil
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Ferreira, Anderson Fuentes
; Ramos Jr, Alberto Novaes
; Maciel, Adjoane Mauricio Silva
; Barbosa, Jaqueline Caracas
; Saavedra, Ramon da Costa
; Antunes, Maria Bernadete de Cerqueira
; Lima, Luisa Helena de Oliveira
; Queiroz, Rejane Christine de Sousa
; Silva, Taynara Lais
; Santiago, Martha Suely Itaparica de Carvalho
; França, Ana Paula
; Domingues, Carla Magda Allan Santos
; Moraes, José Cássio de
; Teixeira, Maria da Gloria
; Silva, Adriana Ilha da
; Ramos Jr., Alberto Novaes
; França, Ana Paula
; Oliveira, Andrea de Nazaré Marvão
; Boing, Antonio Fernando
; Domingues, Carla Magda Allan Santos
; Oliveira, Consuelo Silva de
; Maciel, Ethel Leonor Noia
; Guibu, Ione Aquemi
; Mirabal, Isabelle Ribeiro Barbosa
; Barbosa, Jaqueline Caracas
; Lima, Jaqueline Costa
; Moraes, José Cássio de
; Luhm, Karin Regina
; Caetano, Karlla Antonieta Amorim
; Lima, Luisa Helena de Oliveira
; Antunes, Maria Bernadete de Cerqueira
; Teixeira, Maria da Gloria
; Teixeira, Maria Denise de Castro
; Borges, Maria Fernanda de Sousa Oliveira
; Queiroz, Rejane Christine de Sousa
; Gurgel, Ricardo Queiroz
; Barata, Rita Barradas
; Azevedo, Roberta Nogueira Calandrini de
; Oliveira, Sandra Maria do Valle Leone de
; Teles, Sheila Araújo
; Gama, Silvana Granado Nogueira da
; Mengue, Sotero Serrate
; Simões, Taynãna César
; Nascimento, Valdir
; Araújo, Wildo Navegantes de
.













































RESUMO Objetivo Analisar a cobertura vacinal e os fatores associados à vacinação incompleta em municípios do interior do Nordeste brasileiro. Métodos Trata-se de inquérito domiciliar com amostragem por conglomerados realizado em Vitória da Conquista – Bahia, Caruaru – Pernambuco, Sobral – Ceará e Imperatriz – Maranhão, entre 2020 e 2022. Analisou-se a cobertura vacinal por doses válidas e a hesitação vacinal, com estimativa da razão de chances (odds ratio, OR) ajustada por regressão logística. Resultados Em 1.847 crianças, a cobertura vacinal completa foi 49,2% (IC95% 43,9;54,5). Entre fatores associados à vacinação incompleta destacam-se: maior renda (OR 1,53; IC95% 1,02;2,31), residência em Sobral (OR 4,35; IC95% 3,04;6,21) e >1 filho (OR 1,20; IC95% 1,11;1,32). Decisão de não vacinação pelos pais e dificuldades no deslocamento às unidades de vacinação demarcaram a hesitação vacinal. Conclusão Verificou-se baixas coberturas vacinais e vacinação incompleta associada a questões sociais nos estratos socioeconômicos analisados.
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ABSTRACT Objective To analyze vaccination coverage and factors associated with incomplete vaccination in inland municipalities of Northeastern Brazil. Methods This was a household survey using cluster sampling conducted in Vitória da Conquista, Bahia state, Caruaru, Pernambuco state, Sobral, Ceará state and Imperatriz, Maranhão state between 2020 and 2022. Vaccination coverage by valid doses and vaccine hesitancy were analyzed, with the odds ratio (OR) estimated and adjusted using logistic regression. Results Among 1,847 children, complete vaccination coverage was 49.2% (95%CI 43.9;54.5). Factors associated with incomplete vaccination included: higher income (OR 1.53; 95%CI 1.02;2.31), residence in Sobral (OR 4.35; 95%CI 3.04; 6.21) and >1 child (OR 1.20; 95%CI 1.11;1.32). Parental decision not to vaccinate and difficulties in traveling to vaccination centers contributed to vaccine hesitancy. Conclusion Low vaccination coverage and incomplete vaccination were associated with social issues in the socioeconomic strata analyzed.
4.
Vaccination coverage, vaccine hesitancy and factors associated with incomplete vaccination: a household survey conducted with children born between 2017 and 2018 in the inland municipalities of Northeastern Brazil coverage vaccination 201 20 2
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Ferreira, Anderson Fuentes
; Ramos Jr, Alberto Novaes
; Maciel, Adjoane Mauricio Silva
; Barbosa, Jaqueline Caracas
; Saavedra, Ramon da Costa
; Antunes, Maria Bernadete de Cerqueira
; Lima, Luisa Helena de Oliveira
; Queiroz, Rejane Christine de Sousa
; Silva, Taynara Lais
; Santiago, Martha Suely Itaparica de Carvalho
; França, Ana Paula
; Domingues, Carla Magda Allan Santos
; Moraes, José Cássio de
; Teixeira, Maria da Gloria
; Silva, Adriana Ilha da
; Ramos Jr., Alberto Novaes
; França, Ana Paula
; Oliveira, Andrea de Nazaré Marvão
; Boing, Antonio Fernando
; Domingues, Carla Magda Allan Santos
; Oliveira, Consuelo Silva de
; Maciel, Ethel Leonor Noia
; Guibu, Ione Aquemi
; Mirabal, Isabelle Ribeiro Barbosa
; Barbosa, Jaqueline Caracas
; Lima, Jaqueline Costa
; Moraes, José Cássio de
; Luhm, Karin Regina
; Caetano, Karlla Antonieta Amorim
; Lima, Luisa Helena de Oliveira
; Antunes, Maria Bernadete de Cerqueira
; Teixeira, Maria da Gloria
; Teixeira, Maria Denise de Castro
; Borges, Maria Fernanda de Sousa Oliveira
; Queiroz, Rejane Christine de Sousa
; Gurgel, Ricardo Queiroz
; Barata, Rita Barradas
; Azevedo, Roberta Nogueira Calandrini de
; Oliveira, Sandra Maria do Valle Leone de
; Teles, Sheila Araújo
; Gama, Silvana Granado Nogueira da
; Mengue, Sotero Serrate
; Simões, Taynãna César
; Nascimento, Valdir
; Araújo, Wildo Navegantes de
.













































ABSTRACT Objective To analyze vaccination coverage and factors associated with incomplete vaccination in inland municipalities of Northeastern Brazil. Methods This was a household survey using cluster sampling conducted in Vitória da Conquista, Bahia state, Caruaru, Pernambuco state, Sobral, Ceará state and Imperatriz, Maranhão state between 2020 and 2022. Vaccination coverage by valid doses and vaccine hesitancy were analyzed, with the odds ratio (OR) estimated and adjusted using logistic regression. Results Among 1,847 children, complete vaccination coverage was 49.2% (95%CI 43.9;54.5). Factors associated with incomplete vaccination included: higher income (OR 1.53; 95%CI 1.02;2.31), residence in Sobral (OR 4.35; 95%CI 3.04; 6.21) and >1 child (OR 1.20; 95%CI 1.11;1.32). Parental decision not to vaccinate and difficulties in traveling to vaccination centers contributed to vaccine hesitancy. Conclusion Low vaccination coverage and incomplete vaccination were associated with social issues in the socioeconomic strata analyzed. Brazil Conquista Caruaru Imperatriz 202 2022 analyzed OR regression 1847 1 847 1,84 children 492 49 2 49.2 95CI CI 95 43.954.5. 439545 43.9 54.5 . 43 9 54 5 43.9;54.5) included 1.53 153 53 1.022.31, 102231 1.02 2.31 , 02 31 1.02;2.31) 4.35 435 4 35 3.04 304 3 04 6.21 621 6 21 > 1.20 120 20 1.111.32. 111132 1.11 1.32 11 32 1.11;1.32) 184 84 1,8 49. 954 43.954.5 43954 439 43. 545 54. 43.9;54.5 1.5 15 022 1.022.31 10223 102 1.0 231 2.3 0 1.02;2.31 4.3 3.0 30 6.2 62 1.2 12 111 1.111.32 11113 1.1 132 1.3 1.11;1.32 18 8 1, 43.954. 4395 43.9;54. 1. 1.022.3 1022 10 23 2. 1.02;2.3 4. 3. 6. 1.111.3 1111 13 1.11;1.3 43.954 43.9;54 1.022. 1.02;2. 1.111. 1.11;1. 43.95 43.9;5 1.022 1.02;2 1.111 1.11;1 43.9; 1.02; 1.11;
resumen está disponible en el texto completo
RESUMO Objetivo Analisar a cobertura vacinal e os fatores associados à vacinação incompleta em municípios do interior do Nordeste brasileiro. Métodos Trata-se de inquérito domiciliar com amostragem por conglomerados realizado em Vitória da Conquista – Bahia, Caruaru – Pernambuco, Sobral – Ceará e Imperatriz – Maranhão, entre 2020 e 2022. Analisou-se a cobertura vacinal por doses válidas e a hesitação vacinal, com estimativa da razão de chances (odds ratio, OR) ajustada por regressão logística. Resultados Em 1.847 crianças, a cobertura vacinal completa foi 49,2% (IC95% 43,9;54,5). Entre fatores associados à vacinação incompleta destacam-se: maior renda (OR 1,53; IC95% 1,02;2,31), residência em Sobral (OR 4,35; IC95% 3,04;6,21) e >1 filho (OR 1,20; IC95% 1,11;1,32). Decisão de não vacinação pelos pais e dificuldades no deslocamento às unidades de vacinação demarcaram a hesitação vacinal. Conclusão Verificou-se baixas coberturas vacinais e vacinação incompleta associada a questões sociais nos estratos socioeconômicos analisados. brasileiro Tratase Trata se Bahia Pernambuco Maranhão 202 2022 Analisouse Analisou odds ratio OR logística 1847 1 847 1.84 crianças 492 49 2 49,2 IC95 IC (IC95 43,954,5. 439545 43,9 54,5 . 43 9 54 5 43,9;54,5) destacamse destacam destacam-se 1,53 153 53 1,022,31, 102231 1,02 2,31 , 02 31 1,02;2,31) 4,35 435 4 35 3,046,21 304621 3,04 6,21 3 04 6 21 3,04;6,21 > 1,20 120 20 1,111,32. 111132 1,11 1,32 11 32 1,11;1,32) Verificouse Verificou analisados 184 84 1.8 49, IC9 (IC9 954 43,954,5 43954 439 43, 545 54, 43,9;54,5 1,5 15 022 1,022,31 10223 102 1,0 231 2,3 0 1,02;2,31 4,3 046 3,046,2 30462 304 3,0 621 6,2 3,04;6,2 1,2 12 111 1,111,32 11113 1,1 132 1,3 1,11;1,32 18 8 1. (IC 95 43,954, 4395 43,9;54, 1, 1,022,3 1022 10 23 2, 1,02;2,3 4, 3,046, 3046 30 3, 62 6, 3,04;6, 1,111,3 1111 13 1,11;1,3 43,954 43,9;54 1,022, 1,02;2, 3,046 3,04;6 1,111, 1,11;1, 43,95 43,9;5 1,022 1,02;2 3,04; 1,111 1,11;1 43,9; 1,02; 1,11;
5.
Trachoma-associated morbidity and mortality in Brazil: an ecological study focusing on hospitalization and mortality data, 2000−2022
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Maciel, Adjoane Maurício Silva
; Ferreira, Anderson Fuentes
; Almeida, Nádia Maria Girão Saraiva de
; Maciel, Manuella Maurício Silva
; Silva, Taynara Lais
; Araújo, Mirele Coelho
; Pires Neto, Roberto da Justa
; Ramos Jr, Alberto Novaes
.








Revista da Sociedade Brasileira de Medicina Tropical
- Journal Metrics
ABSTRACT Background: Trachoma is the leading infectious cause of blindness worldwide. It is a neglected tropical disease caused by Chlamydia trachomatis. The objective of this study was to analyze the trachoma-associated morbidity and mortality in Brazil from 2000 to 2022. This ecological time-series study was based on secondary data on trachoma obtained from hospital admissions (trachoma as the primary or secondary cause) and death certificates (trachoma as the underlying or associated cause). Methods: We calculated the sex- and age-standardized rates of hospital admissions and trachoma-specific mortality according to sociodemographic variables and analyzed the spatial distribution. Results: We identified 141/263,292,807 hospital admissions (primary cause: 83.0%) and 126/27,596,830 death certificates (associated cause: 91.3%) related to trachoma. Trachoma-related sequelae were reported in 8.5% of hospital admissions and 6.3% of death certificates. Trachoma was more common in males (hospital admissions and death certificates), people aged ≥70 years (hospital admissions and death certificates), those with brown skin (hospital admissions and death certificates), and those living in the North (hospital admissions) and Northeast (death certificates) regions of Brazil. Conclusions: Despite the relatively low rates of trachoma morbidity in Brazil, the associated mortality rates are of concern. The heterogeneous patterns of occurrence in the country in terms of population and territory reinforce the need to evaluate and monitor the available data, despite the low prevalence, in order to achieve and maintain the elimination targets in Brazil in the future.
6.
Vaccination coverage, hesitancy and associated factors: a household survey of a cohort of children born in 2017 and 2018 in urban areas of state capital cities in the Brazilian Northeast
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Saavedra, Ramon da Costa
; Santiago, Martha Suely Itaparica de Carvalho
; Teixeira, Maria da Glória Lima Cruz
; Antunes, Maria Bernadete de Cerqueira
; Queiroz, Rejane Christine de Sousa
; Lima, Luisa Helena de Oliveira
; Ramos Jr, Alberto Novaes
; Ferreira, Anderson Fuentes
; Maciel, Adjoane Mauricio Silva
; Barbosa, Jaqueline Caracas
; França, Ana Paula
; Domingues, Carla Magda Allan Santos
; Moraes, José Cássio de
; Silva, Adriana Ilha da
; Ramos Jr., Alberto Novaes
; França, Ana Paula
; Oliveira, Andrea de Nazaré Marvão
; Boing, Antonio Fernando
; Domingues, Carla Magda Allan Santos
; Oliveira, Consuelo Silva de
; Maciel, Ethel Leonor Noia
; Guibu, Ione Aquemi
; Mirabal, Isabelle Ribeiro Barbosa
; Barbosa, Jaqueline Caracas
; Lima, Jaqueline Costa
; Moraes, José Cássio de
; Luhm, Karin Regina
; Caetano, Karlla Antonieta Amorim
; Lima, Luisa Helena de Oliveira
; Antunes, Maria Bernadete de Cerqueira
; Teixeira, Maria da Glória Lima Cruz
; Teixeira, Maria Denise de Castro
; Borges, Maria Fernanda de Sousa Oliveira
; Queiroz, Rejane Christine de Sousa
; Gurgel, Ricardo Queiroz
; Barata, Rita Barradas
; Azevedo, Roberta Nogueira Calandrini de
; Oliveira, Sandra Maria do Valle Leone de
; Teles, Sheila Araújo
; Gama, Silvana Granado Nogueira da
; Mengue, Sotero Serrate
; Simões, Taynãna César
; Nascimento, Valdir
; Araújo, Wildo Navegantes de
.












































ABSTRACT Objective To estimate vaccination coverage and analyze sociodemographic factors associated with non-vaccination in children born in 2017 and 2018 in the state capitals of Northeast Brazil. Methods A household survey using cluster sampling was conducted from 2020-2022 to estimate vaccination coverage and hesitancy. Factors associated with non-vaccination were analyzed using logistic regression to calculate Odds Ratios (OR) and their Confidence Intervals (95%CI). Results Natal was the capital with the lowest vaccination coverage, below 75.0% for most immunizers. Teresina had rates equal to or greater than 90.0% for all vaccines. Among those interviewed, 99.1% (95%CI 98.9;99.3) believe that vaccines are important for health; 95.4% (95%CI 95.0;95.8) trust immunobiologicals and 79.6% (95%CI% 78.8;80.3) are not afraid of reactions. Belonging to the highest socioeconomic stratum (adjusted OR: 1.34 – 95%CI 1.20;1.50) was as a factor associated with non-vaccination. Conclusion Low coverage highlights the need for a better understanding of regional specificities and social inequalities.
resumen está disponible en el texto completo
RESUMO Objetivo Estimar a cobertura vacinal e analisar fatores sociodemográficos associados à não vacinação em crianças nascidas vivas em 2017 e 2018 nas capitais do Nordeste brasileiro. Métodos Realizou-se inquérito domiciliar com amostragem por conglomerados, entre 2020 e 2022, para estimar cobertura e hesitação vacinal. Fatores associados à não vacinação foram analisados usando-se regressão logística para calcular odds ratio (OR) e seus intervalos de confiança (IC95%). Resultados A capital com menores coberturas vacinais foi Natal, com < 75,0% para a maioria dos imunizantes; Teresina apresentou coberturas ≥ 90,0% em todos os imunizantes. Dos entrevistados, 99,1% (IC95% 98,9;99,3) acreditavam que vacinas são importantes para a saúde; 95,4% (IC95% 95,0;95,8) confiavam nos imunobiológicos distribuídos pelo governo; e 79,6% (IC95% 78,8;80,3) não tinham medo de reações adversas. Residir em estrato socioeconômico mais alto (OR ajustado: 1,34 – IC95% 1,20;1,50) foi fator associado à não vacinação. Conclusão As baixas coberturas destacam a necessidade de entender melhor as especificidades regionais e as desigualdades sociais.
7.
Effectiveness and Safety of Direct-Acting Antivirals in the Treatment of Chronic Hepatitis C: A Real-life Study in Northeastern Brazil
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Hyppolito, Elodie Bomfim
; Ramos Jr, Alberto Novaes
; Teixeira, Larissa Peixoto
; Bezerra, Arthur Machado
; Mendes, Lucas Arruda
; Silva, Taynara Lais
; Lima, José Milton de Castro
; Arruda, Érico Antonio Gomes de
; Guerra, Eder Janes
; Tavares, Maria Macedo Saraiva
; Lima, Carlos Eduardo Pereira
; Esmeraldo, Ticiana Mota
; Pessoa, Francisco Sérgio Rangel de Paula
; Pierre, Alessandra Maria Montalverne
; Pereira, Karla Brandão
; Araújo Filho, Antônio Haroldo
; Linhares, Lívia Melo Carone
; Ferreira, Anderson Fuentes
; Pires Neto, Roberto da Justa
.



















Revista da Sociedade Brasileira de Medicina Tropical
- Journal Metrics
ABSTRACT Background: This study aimed to evaluate the effectiveness and safety of direct-acting antivirals (DAAs) for hepatitis C treatment by measuring sustained virologic response (SVR) and serious adverse events to help design effective interventions for reducing disease prevalence. Methods: This was a retrospective, observational, real-life study of patients with chronic hepatitis C receiving DAA treatment in the state of Ceará, Brazil. Data were collected in REDCap and analyzed using R® software by the Student's t, chi-square, and Fisher’s exact tests, with a significance level of 5%. Results: In this study, 1075 patients who were diagnosed with hepatitis C infection between October 2015 and October 2023 were included. The mean age of the participants was 56.6 ± 11 years and 60.2% were men. The sample included 51 HIV-infected patients (6.6%), 166 (15,4%) liver transplant recipients, 34 (3,1%) kidney transplant recipients, and 446 patients with cirrhosis (41.4%). The overall SVR rate was 96.4%. The sofosbuvir/daclatasvir/ribavirin regimen used in 354 (32.9%) patients achieved an SVR of 96%. The cure rate was 96.5%, with a lower SVR in patients with cirrhosis (93.4%) than in those with less severe fibrosis (97.9%) (p=0.0015). Serious adverse events associated with ribavirin use occurred in 3.5% of patients. Conclusions: DAA treatment for hepatitis C achieved SVR in real life in all patient profiles, including transplant recipients, HIV carriers, and patients with cirrhosis. Although these drugs are safe, a few decompensated patients with cirrhosis died during treatment.
8.
Measles, mumps and rubella vaccination coverage in capitals and interior region municipalities of Northeast Brazil: a household survey in a cohort of children born in 2017 and 2018
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Maciel, Adjoane Mauricio Silva
; Ramos Jr, Alberto Novaes
; Ferreira, Anderson Fuentes
; Silva, Taynara Lais
; Domingues, Carla Magda Allan Santos
; Saavedra, Ramon da Costa
; Barbosa, Jaqueline Caracas
; França, Ana Paula
; Kerr, Ligia Regina Franco Sansigolo
; Teixeira, Maria da Gloria
; Moraes, José Cássio de
; Silva, Adriana Ilha da
; Ramos Jr., Alberto Novaes
; França, Ana Paula
; Oliveira, Andrea de Nazaré Marvão
; Boing, Antonio Fernando
; Domingues, Carla Magda Allan Santos
; Oliveira, Consuelo Silva de
; Maciel, Ethel Leonor Noia
; Guibu, Ione Aquemi
; Mirabal, Isabelle Ribeiro Barbosa
; Barbosa, Jaqueline Caracas
; Lima, Jaqueline Costa
; Moraes, José Cássio de
; Luhm, Karin Regina
; Caetano, Karlla Antonieta Amorim
; Lima, Luisa Helena de Oliveira
; Antunes, Maria Bernadete de Cerqueira
; Teixeira, Maria da Gloria
; Teixeira, Maria Denise de Castro
; Borges, Maria Fernanda de Sousa Oliveira
; Queiroz, Rejane Christine de Sousa
; Gurgel, Ricardo Queiroz
; Barata, Rita Barradas
; Azevedo, Roberta Nogueira Calandrini de
; Oliveira, Sandra Maria do Valle Leone de
; Teles, Sheila Araújo
; Gama, Silvana Granado Nogueira da
; Mengue, Sotero Serrate
; Simões, Taynãna César
; Nascimento, Valdir
; Araújo, Wildo Navegantes de
.










































ABSTRACT Objective To analyze measles, mumps, and rubella vaccination coverage among children up to 24 months old and factors associated with non-vaccination in a 2017−2018 live birth cohort, in state capitals and large interior region cities in Northeast Brazil. Methods Population-based survey analyzing vaccination coverage and sociodemographic factors through logistic regression. Results For 12,137 children, vaccination coverage was 79.3% (95%CI 76.5;81.8), and the dropout rate was 10.6%. Association with non-vaccination: socioeconomic stratum A (OR-a 1.29; 95%CI 1.10;1.50), living in the interior region (OR-a 1.22; 95%CI 1.07;1.39), no access to the Bolsa Família Program (OR-a 1.19, 95%CI 1.05;1.34), family income ≤BRL 1,000 (OR-a 1.17, 95%CI 1.03;1.31), mother not working (OR-a 1.28, 95%CI 1.15;1.42), >1 child per mother (OR-a 1.12, 95%CI 1.08;1.17), and no vaccination card (OR-a 10.69, 95%CI 6.27;18.20). Conclusion Low vaccination coverage and a high dropout rate in state capitals and municipalities in the interior region of Northeast Brazil.
resumen está disponible en el texto completo
RESUMO Objetivo Analisar a cobertura vacinal contra sarampo, caxumba e rubéola em crianças até 24 meses de idade e os fatores associados à não vacinação em coorte de nascidos-vivos em 2017-2018, em capitais e municípios de grande porte populacional do interior do Nordeste brasileiro. Métodos Inquérito domiciliar populacional com análise de cobertura vacinal e fatores sociodemográficos por regressão logística. Resultados Em 12.137 crianças, cobertura vacinal de 79,3% (IC95% 76,5;81,8) e taxa de abandono de 10,6%. Associação à não vacinação: estrato socioeconômico A (OR-a 1,29; IC95% 1,10;1,50), residir no interior (OR-a 1,22; IC95% 1,07;1,39), não acesso ao Programa Bolsa Família (OR-a 1,19; IC95% 1,05;1,34), renda familiar ≤ R$ 1.000,00 (OR-a 1,17; IC95% 1,03;1,31), mãe sem trabalho remunerado (OR-a 1,28; IC95% 1,15;1,42), > 1 filho por mãe (OR-a 1,12; IC95% 1,08;1,17), sem caderneta de vacinação (OR-a 10,69; IC95% 6,27;18,20). Conclusão Baixa cobertura e alta taxa de abandono vacinal em capitais e municípios do interior do Nordeste.
9.
Diretriz da SBC sobre Diagnóstico e Tratamento de Pacientes com Cardiomiopatia da Doença de Chagas – 2023 202 20 2
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Marin-Neto, José Antonio
; Rassi Jr, Anis
; Oliveira, Gláucia Maria Moraes
; Correia, Luís Claudio Lemos
; Ramos Júnior, Alberto Novaes
; Luquetti, Alejandro Ostermayer
; Hasslocher-Moreno, Alejandro Marcel
; Sousa, Andréa Silvestre de
; Paola, Angelo Amato Vincenzo de
; Sousa, Antônio Carlos Sobral
; Ribeiro, Antonio Luiz Pinho
; Correia Filho, Dalmo
; Souza, Dilma do Socorro Moraes de
; Cunha-Neto, Edecio
; Ramires, Felix Jose Alvarez
; Bacal, Fernando
; Nunes, Maria do Carmo Pereira
; Martinelli Filho, Martino
; Scanavacca, Maurício Ibrahim
; Saraiva, Roberto Magalhães
; Oliveira Júnior, Wilson Alves de
; Lorga-Filho, Adalberto Menezes
; Guimarães, Adriana de Jesus Benevides de Almeida
; Braga, Adriana Lopes Latado
; Oliveira, Adriana Sarmento de
; Sarabanda, Alvaro Valentim Lima
; Pinto, Ana Yecê das Neves
; Carmo, Andre Assis Lopes do
; Schmidt, Andre
; Costa, Andréa Rodrigues da
; Ianni, Barbara Maria
; Markman Filho, Brivaldo
; Rochitte, Carlos Eduardo
; Macêdo, Carolina Thé
; Mady, Charles
; Chevillard, Christophe
; Virgens, Cláudio Marcelo Bittencourt das
; Castro, Cleudson Nery de
; Britto, Constança Felicia De Paoli de Carvalho
; Pisani, Cristiano
; Rassi, Daniela do Carmo
; Sobral Filho, Dário Celestino
; Almeida, Dirceu Rodrigues de
; Bocchi, Edimar Alcides
; Mesquita, Evandro Tinoco
; Mendes, Fernanda de Souza Nogueira Sardinha
; Gondim, Francisca Tatiana Pereira
; Silva, Gilberto Marcelo Sperandio da
; Peixoto, Giselle de Lima
; Lima, Gustavo Glotz de
; Veloso, Henrique Horta
; Moreira, Henrique Turin
; Lopes, Hugo Bellotti
; Pinto, Ibraim Masciarelli Francisco
; Ferreira, João Marcos Bemfica Barbosa
; Nunes, João Paulo Silva
; Barreto-Filho, José Augusto Soares
; Saraiva, José Francisco Kerr
; Lannes-Vieira, Joseli
; Oliveira, Joselina Luzia Menezes
; Armaganijan, Luciana Vidal
; Martins, Luiz Cláudio
; Sangenis, Luiz Henrique Conde
; Barbosa, Marco Paulo Tomaz
; Almeida-Santos, Marcos Antonio
; Simões, Marcos Vinicius
; Yasuda, Maria Aparecida Shikanai
; Moreira, Maria da Consolação Vieira
; Higuchi, Maria de Lourdes
; Monteiro, Maria Rita de Cassia Costa
; Mediano, Mauro Felippe Felix
; Lima, Mayara Maia
; Oliveira, Maykon Tavares de
; Romano, Minna Moreira Dias
; Araujo, Nadjar Nitz Silva Lociks de
; Medeiros, Paulo de Tarso Jorge
; Alves, Renato Vieira
; Teixeira, Ricardo Alkmim
; Pedrosa, Roberto Coury
; Aras Junior, Roque
; Torres, Rosalia Morais
; Povoa, Rui Manoel dos Santos
; Rassi, Sergio Gabriel
; Alves, Silvia Marinho Martins
; Tavares, Suelene Brito do Nascimento
; Palmeira, Swamy Lima
; Silva Júnior, Telêmaco Luiz da
; Rodrigues, Thiago da Rocha
; Madrini Junior, Vagner
; Brant, Veruska Maia da Costa
; Dutra, Walderez Ornelas
; Dias, João Carlos Pinto
.




























































































10.
Epidemiology and control of trachoma in the state of Ceará, Northeast Brazil, 2007-2021 Ceará Brazil 20072021 2007 2021 2007-202 2007202 200 202 2007-20 200720 20 2007-2 20072 2 2007-
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Maciel, Adjoane Maurício Silva
; Ramos Jr, Alberto Novaes
; Gomes, Vivian da Silva
; Ferreira, Anderson Fuentes
; Almeida, Nádia Maria Girão Saraiva de
; Gómez, Daniela Vaz Ferreira
; Favacho, Joana da Felicidade Ribeiro
; Maciel, Manuella Maurício Silva
; Delerino, Antônio Lucas
; Pires Neto, Roberto da Justa
.










Revista da Sociedade Brasileira de Medicina Tropical
- Journal Metrics
ABSTRACT Background: To analyze the epidemiology, surveillance, and control strategies for trachoma in the state of Ceará, northeast Brazil, from 2007 to 2021. Methods: This ecological study was based on secondary data from the Information System on Notifiable Diseases of the Secretary of Health of the state of Ceará. Data from school and home surveys for trachoma detection obtained during the study period were analyzed, the percentage of positivity was estimated, and sociodemographic and clinico-epidemiological factors were investigated. Results: The coverage of trachoma surveillance and control actions in Ceará municipalities increased from 12.5% in 2007 to 55.9% in 2019, but with an average restriction of 8.0% during the COVID-19 pandemic. The estimated trachoma positivity (mean overall positivity) was less than 5.0% (2.76%, 95% CI 1.2-5.2), with a higher proportion of cases in the 5-9-year age group (45.0%, 95% CI 44.6-45.4), in females (53.2%, 95% CI 52.8-53.6), and rural areas (52.6%, 95% CI 52.2-53.0). Positivity above 10.0% was observed in the Litoral Leste/Jaguaribe and Sertão Central regions, with a higher occurrence of the follicular inflammatory clinical form (98.1%, 95% CI 98.0-98.2). Conclusions: Trachoma remains in the state of Ceará and is likely underreported. Despite recent advances, the fragility of health surveillance activities compromises the recognition of the actual magnitude and distribution of trachoma in the state. Accurate information is fundamental for planning, monitoring, and evaluating surveillance and disease control. Background epidemiology Brazil 200 2021 Methods analyzed clinicoepidemiological clinico epidemiological investigated Results 125 12 5 12.5 559 55 9 55.9 2019 80 8 0 8.0 COVID19 COVID 19 COVID-1 pandemic mean 50 5.0 2.76%, 276 2 76 (2.76% 95 1.25.2, 1252 1.2 5.2 , 1 1.2-5.2) 59year year 45.0%, 450 45 (45.0% 44.645.4, 446454 44.6 45.4 44 6 4 44.6-45.4) 53.2%, 532 53 (53.2% 52.853.6, 528536 52.8 53.6 52 52.8-53.6) 52.6%, 526 (52.6% 52.253.0. 522530 52.2 53.0 . 52.2-53.0) 100 10 10.0 LesteJaguaribe Leste Jaguaribe regions 98.1%, 981 98 (98.1% 98.098.2. 980982 98.0 98.2 98.0-98.2) Conclusions underreported advances planning monitoring 20 202 12. 55. 201 8. COVID1 COVID- 5. 2.76% 27 7 (2.76 25 1.25.2 1. 1.2-5.2 45.0% (45.0 645 44.645.4 44645 446 44. 454 45. 44.6-45.4 53.2% (53.2 853 52.853.6 52853 528 52. 536 53. 52.8-53.6 52.6% (52.6 253 52.253.0 52253 522 530 52.2-53.0 10. 98.1% (98.1 098 98.098.2 98098 980 98. 982 98.0-98.2 2.76 (2.7 1.25. 1.2-5. 45.0 (45. 64 44.645. 4464 44.6-45. 53.2 (53. 85 52.853. 5285 52.8-53. 52.6 (52. 52.253. 5225 52.2-53. 98.1 (98. 09 98.098. 9809 98.0-98. 2.7 (2. 1.25 1.2-5 (45 44.645 44.6-45 (53 52.853 52.8-53 (52 52.253 52.2-53 (98 98.098 98.0-98 2. (2 1.2- (4 44.64 44.6-4 (5 52.85 52.8-5 52.25 52.2-5 (9 98.09 98.0-9 ( 44.6- 52.8- 52.2- 98.0-
11.
Scientometric review of research on Neglected Tropical Diseases: a 31-year perspective from the Journal of the Brazilian Society of Tropical Medicine Diseases 31year year 31 3
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Ferreira, Anderson Fuentes
; Heukelbach, Jorg
; Costa, Carlos Henrique Nery
; Souza, Eliana Amorim de
; Maciel, Adjoane Maurício Silva
; Correia, Dalmo
; Ramos Jr, Alberto Novaes
.







Revista da Sociedade Brasileira de Medicina Tropical
- Journal Metrics
ABSTRACT Background: To analyze the temporal evolution of research on Neglected Tropical Diseases (NTDs) published by the Journal of the Brazilian Society of Tropical Medicine (JBSTM). Methods: We performed an analysis of the scientific production in JBSTM on NTDs using an advanced search, which included authors’ descriptors, title, and abstract, and by combining specific terms for each NTDs from 1991 to 2021. Data related to authors, countries of origin, institutions, and descriptors, were evaluated and analyzed over time. Bibliographic networks were constructed using VOSviewer 1.6.16. Results: The JBSTM published 4,268 scientific papers during this period. Of these 1,849 (43.3%) were related to NTDs. The number of publications on NTDs increased by approximately 2.4-fold, from 352 (total 724) during 1991-2000 to 841 (total 2,128) during 2011-2021, despite the proportional reduction (48.6% versus 39.5%). The most common singular NTDs subject of publications included Chagas disease (31.4%; 581/1,849), leishmaniasis (25.5%, 411/1,849), dengue (9.4%, 174/1,849), schistosomiasis (9.0%; 166/1,849), and leprosy (6.5%, 120/1,849), with authorship mostly from Brazil’s South and Southeast regions. Conclusions: Despite the proportional reduction in publications, JBSTM remains an important vehicle for disseminating research on NTDs during this period. There is a need to strengthen the research and subsequent publications on specific NTDs. Institutions working and publishing on NTDs in the country were concentrated in the South and Southeast regions, requiring additional investments in institutions in other regions of the country. Background (NTDs JBSTM. . (JBSTM) Methods search authors descriptors title abstract 199 2021 origin time 1616 1 6 16 1.6.16 Results 4268 4 268 4,26 period 1849 849 1,84 43.3% 433 43 3 (43.3% 2.4fold, 24fold fold 2.4 fold, 2 2.4-fold 35 total 724 19912000 2000 1991-200 84 2,128 2128 128 20112021, 20112021 2011 2021, 2011-2021 48.6% 486 48 (48.6 39.5%. 395 39.5% 39 5 39.5%) 31.4% 314 31 (31.4% 581/1,849, 5811849 581/1,849 , 581 581/1,849) 25.5%, 255 25 (25.5% 411/1,849, 4111849 411/1,849 411 411/1,849) 9.4%, 94 9 (9.4% 174/1,849, 1741849 174/1,849 174 174/1,849) 9.0% 90 0 (9.0% 166/1,849, 1661849 166/1,849 166 166/1,849) 6.5%, 65 (6.5% 120/1,849, 1201849 120/1,849 120 120/1,849) Brazils Brazil s Conclusions (JBSTM 19 202 161 1.6.1 426 26 4,2 184 1,8 43.3 (43.3 4fold 2.4fold 24 2. 72 1991200 200 1991-20 8 2,12 212 12 2011202 201 2011-202 48.6 (48. 39.5 31.4 (31.4 581184 581/1,84 58 25.5% (25.5 411184 411/1,84 41 9.4% (9.4 174184 174/1,84 17 9.0 (9.0 166184 166/1,84 6.5% (6.5 120184 120/1,84 20 1.6. 42 4, 18 1, 43. (43. 7 199120 1991-2 2,1 21 201120 2011-20 48. (48 39. 31. (31. 58118 581/1,8 25.5 (25. 41118 411/1,8 9.4 (9. 17418 174/1,8 9. 16618 166/1,8 6.5 (6. 12018 120/1,8 1.6 (43 19912 1991- 2, 20112 2011-2 (4 (31 5811 581/1, 25. (25 4111 411/1, (9 1741 174/1, 1661 166/1, 6. (6 1201 120/1, 1. 2011- ( (3 581/1 (2 411/1 174/1 166/1 120/1 581/ 411/ 174/ 166/ 120/
12.
National Vaccine Coverage Survey 2020: methods and operational aspects
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Barata, Rita Barradas
; França, Ana Paula
; Guibu, Ione Aquemi
; Vasconcellos, Maurício Teixeira Leite de
; Moraes, José Cássio de
; Teixeira, Maria da Gloria Lima Cruz
Domingues, Carla Magda Alan
Borges, Maria Fernanda de Souza Oliveira
de Azevedo, Roberta Nogueira Calandrini
de Oliveira, Consuelo Silva
Oliveira, Andrea de Nazaré Marvão
Canales, Ivy Thereza
Nascimento, Valdir
Queiroz, Rejane Christine de Souza
Lima, Luísa Helena de Oliveira
Ramos Jr, Alberto Novaes
Barbosa, Jaqueline Caracas
Mirabal, Isabelle Ribeiro Barbosa
Meira, Meiruska
Antunes, Maria Bernadete de Cerqueira
Teixeira, Maria Denise de Castro
Gurgel, Ricardo Queiroz
de Carvalho, Martha Suely Itaparica
Cesar, Tayñana
Maciel, Ethel Leonor Noia
da Gama, Silvana Granado Nogueira
Luhm, Karin Regina
Boing, Antônio Fernando
Mengue, Sotero Serrate
de Oliveira, Sandra Maria do Valle Leone
Lima, Jaqueline Costa
Teles, Sheila Araújo
Caetano, Karlla Antonieta Amorim
de Araújo, Wildo Navegantes





ABSTRACT Objective: The national vaccination coverage survey on full vaccination at 12 and 24 months of age was carried out to investigate drops in coverage as of 2016. Methods: A sample of 37,836 live births from the 2017 or 2018 cohorts living in capital cities, the Federal District, and 12 inner cities with 100 thousand inhabitants were followed for the first 24 months through vaccine record cards. Census tracts stratified according to socioeconomic levels had the same number of children included in each stratum. Coverage for each vaccine, full vaccination at 12 and 24 months and number of doses administered, valid and timely, were calculated. Family, maternal and child factors associated with coverage were surveyed. The reasons for not vaccinating analyzed were: medical contraindications, access difficulties, problems with the program, and vaccine hesitancy. Results: Preliminary results showed that less than 1% of children were not vaccinated, full coverage was less than 75% at all capitals and the Federal District, vaccines requiring more than one dose progressively lost coverage, and there were inequalities among socioeconomic strata, favorable to the highest level in some cities and to the lowest in others. Conclusion: There was an actual reduction in full vaccination in all capitals and the Federal District for children born in 2017 and 2018, showing a deteriorating implementation of the National Immunization Program from 2017 to 2019. The survey did not measure the impacts of the COVID-19 pandemic, which may have further reduced vaccination coverage.
RESUMO Objetivo: Inquérito nacional de cobertura vacinal aos 12 e 24 meses de idade foi realizado para investigar as quedas nas coberturas a partir de 2016. Métodos: Amostra de 37.836 nascidos vivos das coortes de 2017 e 2018 residentes nas capitais, Distrito Federal (DF) e 12 cidades com mais de 100 mil habitantes, acompanhados nos primeiros 24 meses por registros nas cadernetas de vacinação. Setores censitários foram estratificados segundo condições socioeconômicas, e o mesmo número de crianças foi incluído para cada estrato. Calcularem-se coberturas vacinais de cada vacina e coberturas completas aos 12 e 24 meses, doses aplicadas, válidas e oportunas. Fatores familiares, maternos e da criança associados à cobertura foram pesquisados. Os motivos para não vacinar analisados foram: contraindicações médicas, dificuldades de acesso, problemas no funcionamento do programa e hesitação vacinal. Resultados: Os resultados preliminares mostram que menos de 1% das crianças não foram vacinadas, as coberturas pelo esquema completo são menores que 75% em todas as capitais e no DF, as vacinas com mais de uma dose perdem cobertura progressivamente, há diferenças entre os estratos socioeconômicos, favoráveis aos estratos mais altos em algumas cidades e aos estratos mais baixos em outras. Conclusão: Houve realmente redução da cobertura vacinal em todas as capitais e no DF para as crianças nascidas em 2017 e 2018, denotando piora na execução do Programa Nacional de Imunizações durante os anos de 2017 a 2019. O inquérito realizado não mensurou os impactos da pandemia de COVID-19 que podem ter reduzido ainda mais as coberturas vacinais.
13.
National Vaccine Coverage Survey 2020: methods and operational aspects
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Barata, Rita Barradas
; França, Ana Paula
; Guibu, Ione Aquemi
; Vasconcellos, Maurício Teixeira Leite de
; Moraes, José Cássio de
; Teixeira, Maria da Gloria Lima Cruz
Domingues, Carla Magda Alan
Borges, Maria Fernanda de Souza Oliveira
de Azevedo, Roberta Nogueira Calandrini
de Oliveira, Consuelo Silva
Oliveira, Andrea de Nazaré Marvão
Canales, Ivy Thereza
Nascimento, Valdir
Queiroz, Rejane Christine de Souza
Lima, Luísa Helena de Oliveira
Ramos Jr, Alberto Novaes
Barbosa, Jaqueline Caracas
Mirabal, Isabelle Ribeiro Barbosa
Meira, Meiruska
Antunes, Maria Bernadete de Cerqueira
Teixeira, Maria Denise de Castro
Gurgel, Ricardo Queiroz
de Carvalho, Martha Suely Itaparica
Cesar, Tayñana
Maciel, Ethel Leonor Noia
da Gama, Silvana Granado Nogueira
Luhm, Karin Regina
Boing, Antônio Fernando
Mengue, Sotero Serrate
de Oliveira, Sandra Maria do Valle Leone
Lima, Jaqueline Costa
Teles, Sheila Araújo
Caetano, Karlla Antonieta Amorim
de Araújo, Wildo Navegantes





RESUMO Objetivo: Inquérito nacional de cobertura vacinal aos 12 e 24 meses de idade foi realizado para investigar as quedas nas coberturas a partir de 2016. Métodos: Amostra de 37.836 nascidos vivos das coortes de 2017 e 2018 residentes nas capitais, Distrito Federal (DF) e 12 cidades com mais de 100 mil habitantes, acompanhados nos primeiros 24 meses por registros nas cadernetas de vacinação. Setores censitários foram estratificados segundo condições socioeconômicas, e o mesmo número de crianças foi incluído para cada estrato. Calcularem-se coberturas vacinais de cada vacina e coberturas completas aos 12 e 24 meses, doses aplicadas, válidas e oportunas. Fatores familiares, maternos e da criança associados à cobertura foram pesquisados. Os motivos para não vacinar analisados foram: contraindicações médicas, dificuldades de acesso, problemas no funcionamento do programa e hesitação vacinal. Resultados: Os resultados preliminares mostram que menos de 1% das crianças não foram vacinadas, as coberturas pelo esquema completo são menores que 75% em todas as capitais e no DF, as vacinas com mais de uma dose perdem cobertura progressivamente, há diferenças entre os estratos socioeconômicos, favoráveis aos estratos mais altos em algumas cidades e aos estratos mais baixos em outras. Conclusão: Houve realmente redução da cobertura vacinal em todas as capitais e no DF para as crianças nascidas em 2017 e 2018, denotando piora na execução do Programa Nacional de Imunizações durante os anos de 2017 a 2019. O inquérito realizado não mensurou os impactos da pandemia de COVID-19 que podem ter reduzido ainda mais as coberturas vacinais.
ABSTRACT Objective: The national vaccination coverage survey on full vaccination at 12 and 24 months of age was carried out to investigate drops in coverage as of 2016. Methods: A sample of 37,836 live births from the 2017 or 2018 cohorts living in capital cities, the Federal District, and 12 inner cities with 100 thousand inhabitants were followed for the first 24 months through vaccine record cards. Census tracts stratified according to socioeconomic levels had the same number of children included in each stratum. Coverage for each vaccine, full vaccination at 12 and 24 months and number of doses administered, valid and timely, were calculated. Family, maternal and child factors associated with coverage were surveyed. The reasons for not vaccinating analyzed were: medical contraindications, access difficulties, problems with the program, and vaccine hesitancy. Results: Preliminary results showed that less than 1% of children were not vaccinated, full coverage was less than 75% at all capitals and the Federal District, vaccines requiring more than one dose progressively lost coverage, and there were inequalities among socioeconomic strata, favorable to the highest level in some cities and to the lowest in others. Conclusion: There was an actual reduction in full vaccination in all capitals and the Federal District for children born in 2017 and 2018, showing a deteriorating implementation of the National Immunization Program from 2017 to 2019. The survey did not measure the impacts of the COVID-19 pandemic, which may have further reduced vaccination coverage.
14.
High schistosomiasis-related mortality in Northeast Brazil: trends and spatial patterns
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Silva, Bárbara Morgana da
; Ferreira, Anderson Fuentes
; Silva, José Alexandre Menezes da
; Amorim, Rebeca Gomes de
; Domingues, Ana Lúcia Coutinho
; Pinheiro, Marta Cristhiany Cunha
; Bezerra, Fernando Schemelzer de Moares
; Heukelbach, Jorg
; Ramos Jr, Alberto Novaes
.









Revista da Sociedade Brasileira de Medicina Tropical
- Journal Metrics
ABSTRACT Background: We analyzed the trends and spatial patterns of schistosomiasis-related mortality in Northeast Brazil in 2000-2019. Methods: A mixed population-based ecological study was conducted, using information on the underlying or associated causes of death. We used Joinpoint regression analysis to calculate the trends. The spatial analysis included rates, spatial moving averages, and standardized mortality rates. The spatial dependence analysis was based on Getis-Ord's G and Gi* indices (Gi star) and local Moran’s index to check for autocorrelation. Results: A total of 5,814,268 deaths were recorded, of which 9,276 (0.16%) were schistosomiasis-related; 51.0% (n=4,732, adjusted rate 0.90/100,000 inhabitants [95% confidence interval (CI) 0.88-0.93]) were males; 40.0% (n=3,715, adjusted rate 7.40/100.000 inhabitants [95%CI: 7.16-7.64]) were ≥70 years old; 54.8% (n=5,087, crude rate 0.80/100,000 inhabitants) were of mixed/Pardo-Brazilian ethnicity; and 77.9% (n=7,229, adjusted rate 0.86/100,000 inhabitants [95%CI: 0.84-0.88]) lived outside state capitals. The highest proportion of deaths was in the state of Pernambuco (53.9%, n=4,996, adjusted rate 2.72/100,000 inhabitants [95%CI: 2.64-2.79]). Increasing mortality rate was verified in the state of Sergipe. On the coast of the state of Rio Grande do Norte and Bahia, there was spatial dependence of spatio-temporal risk patterns with clusters. Throughout the study period, we found positive spatial autocorrelation and cluster formation. Conclusions: In Northeast Brazil, schistosomiasis persists with a high mortality rate, especially in the coastal region, with heterogeneous spatial and temporal patterns. To eliminate schistosomiasis by 2030, it is necessary to strengthen the financing and management of the unified health system (SUS).
15.
Mortalidade por doenças tropicais negligenciadas no Piauí, Nordeste do Brasil: tendência temporal e padrões espaciais, 2001-2018
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Brito, Sheila Paloma de Sousa
; Ferreira, Anderson Fuentes
; Lima, Mauricélia da Silveira
; Ramos Jr, Alberto Novaes
.




Resumo Objetivo Analisar tendência temporal e padrões espaciais da mortalidade por doenças tropicais negligenciadas (DTNs) no Piauí, Brasil, 2001-2018. Métodos Estudo ecológico misto, com cálculo de razão de risco (RR), análise de tendência espaço-temporal, regressão de Poisson com pontos de inflexão, utilizando-se dados do Sistema de Informações sobre Mortalidade. Resultados Verificaram-se 2.609 óbitos por DTNs no período (4,60/100 mil habitantes), 55,2% por doença de Chagas. Houve maior risco de morte no sexo masculino (RR=1,76; IC95% 1,25;2,46), idade ≥60 anos (RR=40,71; IC95% 10,01;165,53), municípios com vulnerabilidade social média (RR=1,76; IC95% 1,09;2,84), menor porte populacional (RR=1,99; IC95% 1,28;3,10) e macrorregião dos Cerrados (RR=4,51; IC95% 2,51;8,11). Verificou-se tendência de aumento nas taxas de mortalidade em 2001-2008 e redução em 2009-2018. Conclusão A mortalidade por DTNs no Piauí persiste elevada, particularmente por doença de Chagas, entre grupos de maior vulnerabilidade, concentrando-se as maiores taxas no sudoeste da macrorregião do Semiárido, nordeste e sul dos Cerrados.
Abstract Objetive To analyze temporal trends and spatial patterns of mortality due to neglected tropical diseases (NTDs) in Piauí, Brazil, 2001-2018. Methods This was a mixed ecological study, with risk ratio (RR) calculation, spatiotemporal trend analysis, Poisson joinpoint regression, using data from the Mortality Information System. Results There were 2,609 deaths due to NTDs in the period (4.60/100,000 inhabitants), 55.2% were due to Chagas’ disease. There was a higher risk of death in male (RR=1.76; 95%CI 1.25;2.46), being aged ≥60 years (RR=40.71; 95%CI 10.01;165.53), municipalities with medium vulnerability social (RR=1.76; 95%CI 1.09;2.84), smaller population size (RR=1.99; 95%CI 1.28;3.10) and the Cerrados macro-region (RR=4.51; 95%CI 2.51;8.11). There was an upward trend in mortality rates from 2001-2008 and a falling trend from 2009-2018. Conclusion Mortality due to NTDs in Piauí remains high, particularly due to Chagas’ disease, among groups with greater vulnerability, with concentration of higher rates in the southwest of the Semiarid macro-region and the northeast and south of the Cerrados macro-region.
Resumen Objetivo Analizar las tendencias temporales y patrones espaciales de mortalidad por enfermedades tropicales desatendidas (ETD) en Piauí, 2001-2018. Métodos Estudio ecológico mixto, con cálculo de razón de riesgo (RR), análisis de tendencias espacio-temporales, regresión de Poisson con puntos de inflexión, utilizando datos del Sistema de Información de Mortalidad. Resultados Hubo 2.609 defunciones por ETD en el período (4,60/100.000 habitantes), 55,2% por enfermedad de Chagas. Hubo un mayor riesgo de muerte el sexo masculino (RR=1,76; IC95% 1,25;2,46), edad ≥60 años (RR=40,71; IC95% 10,01;165,53), municipios con vulnerabilidad social mediana (RR=1,76; IC95% 1,09;2,84), con menor población (RR=1,99; IC95% 1,28;3,10) y la macrorregión de los Cerrados (RR=4,51; IC95% 2,51;8,11). Hubo tendencia al alta en las tasas de mortalidad de 2001-2008 y reducción de 2009-2018. Conclusión La mortalidad por ETD en Piauí sigue siendo alta, particularmente por la enfermedad de Chagas, entre los grupos con mayor vulnerabilidad, con concentración de tasas más altas en el Suroeste de la macrorregión del Semiárido, noreste y sur de los Cerrados.
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