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BACKGROUND Recurrence is a hallmark of ocular toxoplasmosis (OT), and conditions that influence its occurrence remain a challenge. Natural killer cells (NK) are effectors cells whose primary is cytotoxic function against many parasites, including Toxoplasma gondii. Among the NK cell receptors, immunoglobulin-like receptors (KIR) deserve attention due to their high polymorphism. OBJECTIVES This study aimed to analyse the influence of KIR gene polymorphism in the course of OT infection and its association with recurrences after an active episode. METHODS Ninety-six patients from the Ophthalmologic Clinic of the National Institute of Infectology Evandro Chagas were followed for up to five years. After DNA extraction, genotyping of the patients was performed by polymerase chain reaction sequence-specific oligonucleotide (PCR-SSO) utilising Luminex equipment for reading. During follow-up, 60.4% had a recurrence. FINDINGS We identified 25 KIR genotypes and found a higher frequency of genotype 1 (31.7%) with worldwide distribution. We note that the KIR2DL2 inhibitor gene and the gene activator KIR2DS2 were more frequent in patients without recurrence. Additionally, we observed that individuals who carry these genes progressed recurrence episodes slowly compared to individuals who do not carry these genes. MAIN CONCLUSIONS The KIR2DL2 and KIR2DS2 are associated as possible protection markers against ocular toxoplasmosis recurrence (OTR).

https://doi.org/10.1590/0074-02760220203

Association between obesity and hospitalization in mild COVID-19 adult outpatients in Brazil: a prospective cohort study
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Sartor, Ivaine Tais Sauthier

; David, Caroline Nespolo de

; Telo, Gabriela Heiden

; Zavaglia, Gabriela Oliveira

; Fernandes, Ingrid Rodrigues

; Kern, Luciane Beatriz

; Polese-Bonatto, Márcia

; Azevedo, Thaís Raupp

; Santos, Amanda Paz

; Almeida, Walquiria Aparecida Ferreira de

; Porto, Victor Bertollo Gomes

; Varela, Fernanda Hammes

; Scotta, Marcelo Comerlato

; Rosa, Regis Goulart

; Stein, Renato T.

Archives of Endocrinology and Metabolism

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aug 2022, Volume 66 N. 4 Pages 512 - 521

Abstract: En | Text: En | PDF: En

ABSTRACT Objective: To evaluate the association between obesity and hospitalization in mild COVID-19 adult outpatients in Brazil. Subjects and methods: Adults with signs and symptoms suggestive of acute SARS-CoV-2 infection who sought treatment in two hospital (public and private) emergency departments were prospectively enrolled. Patients with confirmed COVID-19 at inclusion were followed by phone calls at days D7, D14 and D28. Multivariable logistic regression models were employed to explore the association between obesity and other potential predictors for hospitalization. Results: A total of 1,050 participants were screened, and 297 completed the 28-day follow-up and were diagnosed with COVID-19 by RT-PCR. The median age was 37.2 (IQR 29.7-44.6) years, and 179 (60.0%) were female. The duration of symptoms was 3.0 (IQR 2.0-5.0) days, and 10.0 (IQR 8.0-12.0) was the median number of symptoms at inclusion. Ninety-five (32.0%) individuals had obesity, and 233 (78.5%) had no previous medical conditions. Twenty-three participants (7.7%) required hospitalization during the follow-up period. After adjusting, obesity (BMI ≥ 30.0 kg/m2) (OR = 2.69, 95% CI 1.63-4.83, P < 0.001) and older age (OR = 1.05, 95% CI 1.01-1.09, P < 0.001) were significantly associated with higher risks of hospitalization. Conclusion: Obesity, followed by aging, was the main factor associated with hospital admission for COVID-19 in a young population in a low-middle income country. Our findings highlighted the need to promote additional protection for individuals with obesity, such as vaccination, and to encourage lifestyle changes.

https://doi.org/10.20945/2359-3997000000486

Neoextrativismo, garimpo e vulnerabilização dos povos indígenas como expressão de um colonialismo persistente no Brasil
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Porto, Marcelo Firpo de Souza

; Rocha, Diogo

Saúde em Debate

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jun 2022, Volume 46 N. 133 Pages 487 - 500

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO O artigo, em forma de ensaio, defende que as ameaças de vulnerabilização mais recentes contra os povos indígenas, intensificadas no contexto da pandemia de Covid-19, refletem um colonialismo persistente. Este se atualiza no contexto da inserção semiperiférica do Brasil no sistema-mundo capitalista, neoliberal e globalizado como exportador de commodities produzidas pelos dois setores estratégicos do neoextrativismo, a mineração e o agronegócio. O modelo neoextrativista beneficia principalmente grupos transnacionais e elites nacionais com grande poder econômico e político, além do próprio setor financeiro. Além disso, estabelece conexões com o submundo dos circuitos inferiores e ilegais vinculados a setores como o garimpo, e incluem desde práticas de violência até a lavagem de dinheiro com a participação de grupos locais que, nos últimos tempos, vêm assumindo crescente poder político e institucional. Tais grupos fazem parte do complexo mosaico do fortalecimento de ideologias de extrema-direita nos últimos anos no cenário nacional, que vêm reunindo alianças. O artigo tem por base experiências de pesquisa colaborativa nos últimos anos com o povo Munduruku na região do Médio Tapajós, com reflexões sobre a atual expansão de agenda política anti-indígena.

ABSTRACT This essay argues that the most recent threats of vulnerability against indigenous peoples, intensified in the context of the COVID-19 pandemic, reflect a persistent colonialism. This is updated in the context of Brazil’s semi-peripheral insertion into the capitalist, neoliberal, and globalized world-system as an exporter of commodities produced by the two strategic sectors of neo-extractivism, mining and agribusiness. The neo-extractivist model benefits mainly transnational groups and national elites with great economic and political power, in addition to the financial sector. Moreover, it establishes connections with the underworld of inferior and illegal circuits linked to sectors such as mining, and ranges from practices of violence to money laundering with the participation of local groups that, in recent times, have been assuming growing political and institutional power. Such groups are part of the complex mosaic of the strengthening of far-right ideologies in recent years on the national scene, which have been gathering alliances. This essay is based on collaborative research experiences in recent years with the Munduruku people in the Middle Tapajós region, along with reflections on the current expansion of the anti-indigenous political agenda.

https://doi.org/10.1590/0103-1104202213317

Diretriz Conjunta sobre Tromboembolismo Venoso – 2022
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Albricker, Ana Cristina Lopes

; Freire, Cláudia Maria Vilas

; Santos, Simone Nascimento dos

; Alcantara, Monica Luiza de

; Saleh, Mohamed Hassan

; Cantisano, Armando Luis

; Teodoro, José Aldo Ribeiro

; Porto, Carmen Lucia Lascasas

; Amaral, Salomon Israel do

; Veloso, Orlando Carlos Gloria

; Petisco, Ana Cláudia Gomes Pereira

; Barros, Fanilda Souto

; Barros, Márcio Vinícius Lins de

; Souza, Adriano José de

; Sobreira, Marcone Lima

; Miranda, Robson Barbosa de

; Moraes, Domingos de

; Verrastro, Carlos Gustavo Yuji

; Mançano, Alexandre Dias

; Lima, Ronaldo de Souza Leão

; Muglia, Valdair Francisco

; Matushita, Cristina Sebastião

; Lopes, Rafael Willain

; Coutinho, Artur Martins Novaes

; Pianta, Diego Bromfman

; Santos, Alair Augusto Sarmet Moreira Damas dos

; Naves, Bruno de Lima

; Vieira, Marcelo Luiz Campos

; Rochitte, Carlos Eduardo

Arquivos Brasileiros de Cardiologia

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apr 2022, Volume 118 N. 4 Pages 797 - 857

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

https://doi.org/10.36660/abc.20220213

Neoextrativismo, garimpo e vulnerabilização dos povos indígenas como expressão de um colonialismo persistente no Brasil
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Porto, Marcelo Firpo de Souza

; Rocha, Diogo

Saúde em Debate

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apr 2022, Volume 46 N. 133 Pages 487 - 500

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

https://doi.org/10.1590/0103-1104202213317

Low performance of a SARS-CoV-2 point-of-care lateral flow immunoassay in symptomatic children during the pandemic
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Scotta, Marcelo Comerlato

; David, Caroline Nespolo de

; Varela, Fernanda Hammes

; Sartor, Ivaine Tais Sauthier

; Polese-Bonatto, Márcia

; Fernandes, Ingrid Rodrigues

; Zavaglia, Gabriela Oliveira

; Ferreira, Charles Francisco

; Kern, Luciane Beatriz

; Santos, Amanda Paz

; Krauzer, João Ronaldo Mafalda

; Pitrez, Paulo Márcio

; Almeida, Walquiria Aparecida Ferreira de

; Porto, Victor Bertollo Gomes

; Stein, Renato T.

Jornal de Pediatria

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apr 2022, Volume 98 N. 2 Pages 136 - 141

Abstract: En | Text: En | PDF: En

Abstract Objective: to evaluate the accuracy of an antibody point-of-care lateral flow immunoassay (LFI -Wondfo Biotech Co., Guangzhou, China) in a pediatric population. Methods: children and adolescents (2 months to 18 years) with signs and symptoms suggestive of acute SARS-CoV-2 infection were prospectively investigated with nasopharyngeal RT-PCR and LFI at the emergency room. RT-PCR was performed at baseline, and LFI at the same time or scheduled for those with less than 7 days of the clinical picture. Overall accuracy, sensitivity and specificity were assessed, as well as according to the onset of symptoms (7-13 or ≥14 days) at the time of the LFI test. Results: In 175 children included, RT-PCR and LFI were positive in 51 (29.14%) and 36 (20.57%), respectively. The overall sensitivity, specificity, positive and negative predictive value was 70.6% (95%CI 56.2-82.5), 96.8% (95%CI 91.9-99.1), 90.0% (95%CI 77.2-96.0), and 88.9% (95%CI 83.9-92.5), respectively. At 7-13 and ≥14 days after the onset of symptoms, sensitivity was 60.0% (95%CI 26.2-87.8) and 73.2% (95%CI 57.1-85.8) and specificity was 97.9% (95%CI 88.7-99.9) and 96.1% (95%CI 89.0-99.2), respectively. Conclusion: Despite its high specificity, in the present study the sensitivity of LFI in children was lower (around 70%) than most reports in adults. Although a positive result is informative, a negative LFI test cannot rule out COVID-19 in children.

https://doi.org/10.1016/j.jped.2021.04.010

Estatística Cardiovascular – Brasil 2021
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Oliveira, Gláucia Maria Moraes de

; Brant, Luisa Campos Caldeira

; Polanczyk, Carisi Anne

; Malta, Deborah Carvalho

; Biolo, Andreia

; Nascimento, Bruno Ramos

; Souza, Maria de Fatima Marinho de

; Lorenzo, Andrea Rocha De

; Fagundes Júnior, Antonio Aurélio de Paiva

; Schaan, Beatriz D.

; Castilho, Fábio Morato de

; Cesena, Fernando Henpin Yue

; Soares, Gabriel Porto

; Xavier Junior, Gesner Francisco

; Barreto Filho, Jose Augusto Soares

; Passaglia, Luiz Guilherme

; Pinto Filho, Marcelo Martins

; Machline-Carrion, M. Julia

; Bittencourt, Marcio Sommer

; Pontes Neto, Octavio M.

; Villela, Paolo Blanco

; Teixeira, Renato Azeredo

; Sampaio, Roney Orismar

; Gaziano, Thomaz A.

; Perel, Pablo

; Roth, Gregory A.

; Ribeiro, Antonio Luiz Pinho

Arquivos Brasileiros de Cardiologia

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jan 2022, Volume 118 N. 1 Pages 115 - 373

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

https://doi.org/10.36660/abc.20211012

Fim dos benefícios fiscais aos agrotóxicos, sustentabilidade da agricultura e a saúde no Brasil
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Soares, Wagner Lopes

; Cunha, Lucas

; Porto, Marcelo Firpo

Saúde em Debate

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2022, Volume 46 N. spe2 Pages 236 - 248

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO O presente artigo avaliou o fim dos benefícios fiscais dados aos agrotóxicos a partir dos microdados do Censo agropecuário de 2017. Realizou-se um estudo descritivo explorando duas variáveis pesquisadas: a despesa com agrotóxicos e o lucro obtido com a atividade agropecuária. Foram traçados cenários de aplicação de alíquotas de tributação dos agrotóxicos e os seus respectivos aumentos de preços, o que possibilitou avaliar os impactos diretos na lucratividade dos produtores. O cenário de tributação que gere um aumento de 15% nos preços dos agrotóxicos reduziria a lucratividade em cerca de 5,1% em 2017 (R$ 4,8 bilhões). Contudo, os maiores impactados seriam os produtores de commodities, com uma redução média de 9,6% na lucratividade. Discutiram-se esses resultados à luz de dois prismas: o impacto na renda do produtor e possíveis consequências no aumento de preços da cesta básica; e a capacidade da função extrafiscal do imposto em regular o uso dos agrotóxicos e redirecionar possíveis mudanças na tomada de decisão sobre os métodos de controle de pragas mais sustentáveis. Concluiu-se que há necessidade de harmonizar regras fiscais à uma política pública mais equilibrada no âmbito do setor agropecuário que garantisse a defesa da saúde da população e a sustentabilidade ambiental.

ABSTRACT This paper assesses the end of the tax incentives given to pesticides, based on the constitutionality analysis lawsuit (ADI 5553) that will be judged by the Supreme Court, which discusses the exemptions of ICMS and IPI on these products. Based on the last Brazilian Census Survey we evaluate the tax incidence of ICMS and IPI on agricultural expenditure and profitability of the agricultural establishment in some diferent scenarios. A 15% increase in pesticide prices would have an impact on costs and profitability of approximately R$ 4 and R$ 6.8 billion (-7%), respectively. This represents a value of almost R$ 10 billion less than calculated by a similar study released by the Sindicato Nacional da Indústria da Defesa Vegetal (Sindiveg) for a scenario of equivalent price increase. We discussed not only the impact results in income of the producer, but also the capacity of the extrafiscal function of the tax to regulate the use of pesticides and redirect possible changes in decision making on pest control methods, enabling the transition to a more sustainable and healthy agriculture. Finally, we conclude that, regardless of the outcome of the judgment of ADI 5553, the problem of negative externalities resulting from the use of pesticides does not end with the end of fiscal incentives to them, as they depend on the formulation of a more balanced public policy within the scope of the agricultural sector that would guarantee the defense of the population’s health and environmental sustainability.

https://doi.org/10.1590/0103-11042022e216

Luz, câmera, cocriação: o cinema documentário como inspiração para descolonizar a produção de conhecimentos
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Fasanello, Marina Tarnowski

; Porto, Marcelo Firpo

Saúde em Debate

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2022, Volume 46 N. spe6 Pages 70 - 82

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO O artigo discute o papel do cinema documentário como inspiração para o desenvolvimento de metodologias sensíveis co-labor-ativas em campos interdisciplinares como a saúde coletiva, envolvendo a aproximação entre cientistas, cineastas e movimentos sociais em torno de problemas de saúde e ambiente. O artigo ancora-se na noção de tornar comum usada por Paulo Freire, e na obra de Boaventura de Sousa Santos denominada de epistemologias do Sul e sua proposta para descolonizar o conhecimento, o que inclui a realização de ecologias de saberes. A partir de tais referenciais, o documentário é refletido para além de uma obra artística e autoral apoiado na ciência, mas enquanto emergência de novas epistemes e saberes conectados a lutas sociais e processos emancipatórios que podem inspirar a renovação teórico-metodológica na produção de conhecimentos. No artigo, selecionaram-se dois documentários que versam sobre as lutas contra a agricultura capitalista e os efeitos do uso intensivo de agrotóxicos, assim como a promoção da agroecologia e da reforma agrária como alternativas para sociedades mais justas, saudáveis e sustentáveis. Como resultado, a análise de tais documentários demonstra o potencial de reunir ciência, política, arte e ética enquanto práticas interdisciplinares e interculturais de co-labor-ação, coprodução e cocriação.

ABSTRACT The article discusses the role of documentary cinema as inspiration for the development of sensitive collaborative methodologies in interdisciplinary fields, such as collective health, involving the approximation between scientists, filmmakers, and social movements around health and environmental problems. The article is anchored on the notion of making common used by Paulo Freire and in the work of Boaventura de Sousa Santos, called Epistemologies of the South, and his proposal to decolonize knowledge, which includes the realization of ecology of knowledges. From such references, the documentary is reflected beyond an artistic and authorial work based on science, but as an emergence of new epistemes and knowledge connected to social struggles and emancipatory processes that can inspire theoreticalmethodological renewal in the production of knowledges. In the article, we selected two documentaries that address the struggles against capitalist agriculture and the effects of the intensive use of pesticides, as well as the promotion of agroecology and agrarian reform as alternatives for fairer, healthier, and more sustainable societies. As a result, the analysis of those documentaries demonstrates the potential of bringing together science, politics, art, and ethics as interdisciplinary and intercultural practices of co-labor-action, co-production, and co-creation.

https://doi.org/10.1590/0103-11042022e607

10.

Comunidade Ampliada de Pesquisa-Ação: construindo saberes e práticas no diálogo cotidiano e afetivo com o território
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Pivetta, Fatima

; Cunha, Marize Bastos da

; Porto, Marcelo Firpo

Saúde em Debate

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2022, Volume 46 N. spe6 Pages 162 - 174

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO O artigo objetivou discutir os aprendizados com as Comunidades Ampliadas de Pesquisa-Ação (CAP) em favelas do Rio de Janeiro, como contribuição às discussões conceituais e metodológicas no campo da saúde coletiva, na perspectiva da Promoção Emancipatória da Saúde e da Educação Popular. Com as CAP, como foi sintetizada esta metodologia, buscou-se responder a um dos principais desafios de pesquisas qualitativas em favelas: uma construção metodológica que possibilite a compreensão da forma por meio da qual os moradores desses territórios experimentam e respondem às situações de saúde. O território, como categoria integrativa de análise para compreender os processos de determinação social da saúde, impõe à CAP se configurar como uma rede de diálogos interdisciplinares e entre diferentes agentes sociais. A análise da base material documental produzida no período 2003-2020, utilizando a sistematização de experiência como metodologia de pesquisa, resultou na identificação de três eixos que estruturam o método CAP, metodologia assim denominada: 1) o cotidiano como engrenagem da dinâmica da CAP; 2) o território e os agentes sociais do diálogo; e 3) as ferramentas artesanais de co-laboração com o território. A partir desses eixos, conclui-se ser o método CAP uma rede de produção de conhecimentos e interlocução entre pessoas-lugares-territórios.

ABSTRACT The article aims to discuss the lessons learned from the Extended Action-Research Community (CAP) in favelas in Rio de Janeiro, as a contribution to conceptual and methodological discussions in the field of Public Health, from the perspective of Emancipatory Health Promotion and Popular Education. With the CAPs, we seek to respond to one of the main challenges of qualitative research in favelas: a methodological construction that makes it possible to understand the way the residents of these territories experience and respond to health situations. The territory, as an integrative category of analysis to understand the processes of social determination of health, requires CAP to configure itself with a network of interdisciplinary dialogues and between different social agents. The analysis of the documentary material base produced in the period 2003-2020, using the systematization of experience as a research methodology, resulted in the identification of three axes that structure the CAP method: 1) everyday life as the dynamics gear of CAP; 2) territory and the social agents of dialogue; and 3) artisanal tools to collaborate with the territory. Based on these axes, we conclude that the CAP method is a network for knowledge production and dialogue between people-places-territories.

https://doi.org/10.1590/0103-11042022e614

11.

Sessenta Anos da Profissão de Psicóloga(o) no Brasil: Percursos e Desafios
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Pizzinato, Adolfo

; Noronha, Ana Paula Porto

; Hur, Domenico Uhng

; Barros, João Paulo Pereira

; Calegare, Marcelo

; Guareschi, Neuza Maria

Psicologia: Ciência e Profissão

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2022, Volume 42 N. spe elocation e264734

Abstract: Pt | Text: Pt | PDF: Pt

https://doi.org/10.1590/1982-3703003264734

12.

Visceral leishmaniasis caused by Leishmania (Leishmania) amazonensis associated with Hodgkin’s lymphoma
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Porto, Victor Bertolo Gomes

; Carvalho, Laína Bubach

; Buzo, Bruno Fernando

; Litvoc, Marcelo Nobrega

; Santos, Ana Catharina S.

; Rocci, Rafael Avila

; Soares, Sandra Regina Castro

; Zampieri, Ricardo Andrade

; Duarte, Maria Irma Seixas

; Lindoso, José Angelo Lauletta

Revista do Instituto de Medicina Tropical de São Paulo

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2022, Volume 64 elocation e51

Abstract: En | Text: En | PDF: En

ABSTRACT Visceral leishmaniasis (VL) is mainly caused by Leishmania (Leishmania) donovani and Leishmania (L.) infantum; however, other Leishmania species have been associated with VL. We report a case of a patient simultaneously diagnosed with VL caused by Leishmania (L.) amazonensis and Hodgkin’s lymphoma. After treatment with liposomal amphotericin B and chemotherapy, the patient presented a clinical cure. This case report reinforces the hypothesis that other Leishmania species can cause visceral lesions mainly related to immunosuppression.

https://doi.org/10.1590/s1678-9946202264051

13.

Fim dos benefícios fiscais aos agrotóxicos, sustentabilidade da agricultura e a saúde no Brasil
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Soares, Wagner Lopes

; Cunha, Lucas

; Porto, Marcelo Firpo

Saúde em Debate

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2022, Volume 46 N. spe2 Pages 236 - 248

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

https://doi.org/10.1590/0103-11042022e216

14.

The many faces of endometriosis
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Souza Filho, Marcelo Luis Pereira de

; Costa, Talita Porto da

; Freitas Junior, Nathanael Pinheiro de

; Souza, Maiara Ferreira de

; Athanazio, Daniel Abensur

Autopsy and Case Reports

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2022, Volume 12 elocation e2021409

Abstract: En | Text: En | PDF: En

ABSTRACT Endometriosis is a common disease; however, unusual findings may cause diagnostic difficulties. We present herein three cases illustrating different morphological appearances of endometriosis: 1) endometriosis with atypical hyperplasia associated with bilateral ovarian carcinoma (mixed clear cell/endometrioid in the left ovary and endometrioid in the right ovary); 2) deep infiltrating endometriosis with intravascular spread, polypoid configuration in peritoneal surfaces, and involvement of a lymph node; and 3) decidualized endometriosis with prominent myxoid/mucinous change and multivacuolated (pseudoxanthoma) cells. Awareness of uncommon morphological manifestations of endometriosis is important to avoid improper consideration of malignancy.

https://doi.org/10.4322/acr.2021.409

15.

Luz, câmera, cocriação: o cinema documentário como inspiração para descolonizar a produção de conhecimentos
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Fasanello, Marina Tarnowski

; Porto, Marcelo Firpo

Saúde em Debate

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2022, Volume 46 N. spe6 Pages 70 - 82

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

https://doi.org/10.1590/0103-11042022e607

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Glossary and search help

You can enrich your search in a very simple way. Use the search indexes combined with the connectors (AND or OR) and specify more your search.

For example, if you want to search for articles about
cases of dengue in Brasil in 2015, use:
ti:dengue and publication_year:2015 and aff_country:Brasil

See below the complete list of search indexes that can be used:

Index code	Element
ti	article title
au	author
kw	article keywords
subject	subject (title words, abstract and keywords)
ab	abstract
ta	journal short title (e.g. Cad. Saúde Pública)
journal_title	journal full title (e.g. Cadernos de Saúde Pública)
la	publication language code (e.g. pt - Portuguese, es - Spanish)
type	document type
pid	publication identifier
publication_year	publication year of publication
sponsor	sponsor
aff_country	country code of the author's affiliation
aff_institution	author affiliation institution
volume	article volume
issue	article issue
elocation	elocation
doi	DOI number
issn	journal ISSN
in	SciELO colection code (e.g. scl - Brasil, col - Colômbia)
use_license	article usage license code

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