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Abstract The mechanisms that stimulate the proliferation of epithelial cells in inflammatory periapical lesions are not completely understood and the literature suggests that changes in the balance between apoptosis and immunity regulation appear to influence this process. Objective: To evaluate the expression of the epidermal growth factor (EGF), its receptor (EGFR) and of the keratinocyte growth factor (KGF), the presence of CD57+ cells, the epithelial cell proliferation index, and the expression of the Bcl-2 protein in inflammatory periapical lesions (IPL) at different stages of development. Methodology: Our sample was composed of 52 IPLs (22 periapical granulomas - PG - and 30 periapical cysts - PC), divided into three groups: PGs, small PCs, and large PCs. Specimens were processed for histopathologic and immunohistochemical analyses. Sections were evaluated according to the amount of positive staining for each antibody. Results: We found no significant differences among the groups regarding Bcl-2 (p=0.328) and Ki-67 (p>0.05) expression or the presence of CD57+ cells (p=0.748). EGF (p=0.0001) and KGF (p=0.0001) expression was more frequent in PCs than in PGs, and CD57+ cells were more frequent in IPLs with intense inflammatory infiltrates (p=0.0001). We found no significant differences in KGF (p=0.423), Bcl-2 (p=0.943), and EGF (p=0.53) expression in relation to inflammatory infiltrates or to the type of PC epithelial lining, but observed greater KGF expression (p=0.0001) in initial PCs. EGFR expression was similar among the groups (p>0.05). Conclusion: More frequent EGF and KGF expression in PCs and the greater presence of CD57+ cells in lesions with intense inflammatory infiltrates suggest that these factors influence IPL development. The greater KGF expression in initial PCs suggests its importance for the initial stages of PC formation.

https://doi.org/10.1590/1678-7757-2021-0413

Participación social, un factor a considerar en la evaluación clínica del adulto mayor: una revisión narrativa
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Sepúlveda-Loyola, Walter

; Dos Santos Lopes, Rosielma

; Tricanico Maciel, Renata Pires

; Suziane Probst, Vanessa

Revista Peruana de Medicina Experimental y Salud Pública

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jun 2020, Volume 37 N. 2 Pages 341 - 349

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

ABSTRACT Social participation is defined as the integration of people into community activities in voluntary or mandatory, formal and informal social groups, which could have consequences concerning the health of the older population. A search was conducted on Pubmed, Scielo, Scopus and Google Scholar. For this review, 16 articles studying the impact of social participation on older adults were analyzed, including a total of 73,698,096 individuals from North America, Asia, Europe, and Latin America. Social participation is considered a protective factor for the mental and physical health of older adults, which has been associated with decreases in disability, co-morbidities, and mortality. For this reason, it is suggested that it should be evaluated in clinical practice. This would make it possible to orient and refer older adults to participate in certain community organizations, mainly those who do not have support networks, who are not linked to community groups, who have symptoms of depression or who are beginning to show physical or cognitive deterioration. In this way, public health could increase its prevention and health promotion actions through community organizations. On the other hand, the lack of instruments and consensus to evaluate social participation was discussed in this review where a questionnaire to evaluate the social participation of the older adult has been proposed to be validated and studied in the future.

RESUMEN La participación social es definida como la integración de las personas a actividades de la comunidad en grupos sociales voluntarios u obligatorios, formales e informales, lo cual podría tener consecuencias en la salud de la población adulta mayor. Fue realizada una búsqueda en Pubmed, Scielo, Scopus y Google Scholar. Para esta revisión se analizaron 16 artículos que estudiaban el impacto de la participación social en adultos mayores, incluyendo un total de 73 698 096 individuos de Norteamérica, Asia, Europa, y América latina. La participación social es considerada como un factor protector para la salud mental y física de los adultos mayores, la cual ha sido asociada a disminuciones de la discapacidad, comorbilidades y mortalidad. Por esta razón, se sugiere que debe ser evaluada en la práctica clínica. Esto permitiría orientar y derivar a los adultos mayores a participar de determinadas organizaciones comunitarias, principalmente aquellos que no tienen redes de apoyo, que no están vinculados a grupos comunitarios, que tienen síntomas de depresión o que están iniciando un cuadro de deterioro físico o cognitivo. De este modo, la salud pública podría aumentar sus acciones de prevención y promoción de la salud por medio de las organizaciones comunitarias. Por otro lado, la falta de instrumentos y consensos para evaluar la participación social fue discutida en esta revisión donde se ha propuesto un cuestionario de evaluación de la participación social del adulto mayor que debe ser validado y estudiado en el futuro.

https://doi.org/10.17843/rpmesp.2020.372.4518

Correlación entre actividad física en la vida diaria y biomarcadores de estrés oxidativo y metabólicos en adultos mayores
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Cordeiro Maluf, Jordana

; Sepúlveda-Loyola, Walter

; Tricanico Maciel, Renata Pires

; Carvalho, Giovanna

; Pereira, Paulo Sérgio

; Suziane Probst, Vanessa

Medicas UIS

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apr 2020, Volume 33 N. 1 Pages 13 - 19

Abstract: Es En | Text: Es En | PDF: Es | PDF: En

Resumen Introducción: el envejecimiento se caracteriza por cambios fisiológicos, entre ellos un aumento del estrés oxidativo (EO), que es un factor de riesgo para el desarrollo de múltiples patologías. La actividad física en la vida diaria (AFVD) es un factor protector para la salud y podría estar asociado con una disminución del EO. Objetivo: analizar la correlación entre AFVD y los biomarcadores de EO en adultos mayores. Materiales y Métodos: se incluyeron 35 adultos mayores (edad: 69 ± 7 años, hombres: 57%). La actividad física fue evaluada utilizando el acelerómetro triaxial DynaPort, que midió el tiempo en 6 actividades: Caminata rápida, acostado, sentado, de pie, en movimiento y caminata lenta, respectivamente. Fueron evaluados los siguientes biomarcadores de sangre periférica: Productos avanzados de oxidación de proteínas (AOPP), óxido nítrico (NOx), capacidad antioxidante total (TRAP), grupo de sulfhidrilo (SH) y enzima superóxido dismutasa (SOD). Además, el nivel glicémico, IMC y circunferencia abdominal. Los coeficientes de correlación de Pearson o Spearman fueron utilizados respectivamente, con p < 0.05 e IC: 95%. Resultados: SOD tuvo una correlación con tiempos de caminata rápida (r = 0.6) y de movimiento (r = 0.6). AOPP tuvo una correlación con los tiempos de caminata rápida (r = -0.4), caminata lenta (r = -0.5), de pie (r = -0.4), en movimiento (r = -0.4) y acostado (r = 0.5). El IMC tuvo una correlación con el tiempo en movimiento (r = -0.4). La glucosa fue correlacionada con el tiempo de caminata rápida (-r = 0.63), de pie (r = -0.5), en movimiento (r = -0.6), caminata lenta (r = -0.61) y acostado (r = 0.54). Conclusiones: niveles aumentados de actividad física de la vida diaria están asociados con mayor capacidad antioxidante, menor estrés oxidativo, nivel glicémico e IMC. MÉD.UIS.2020;33(1): 13-9.

Abstract Introduction: aging is characterized by physiological changes, including increased oxidative stress (OS), which is a risk factor for the development of multiple pathologies. Physical activity in daily life (PADL) is a protective factor for health and could be associated with a decrease in oxidative stress. Objective: to analyze the correlation of PADL and blood biomarkers of OS in older adults. Materials and Method: 35 older adults were included (age: 69 ± 7 years, men: 57%). PADL was objectively evaluated using the DynaPort triaxial accelerometer, which measured the time in 6 different activities: Fast walking, lying, sitting, standing, moving and slow walking, respectively. The following biomarkers from peripheral blood were measured: advanced protein oxidation products (AOPP), nitric oxide (NOx), total antioxidant potential (TRAP), sulfhydryl group (SH) and superoxide enzyme dismutase (SOD). Blood glucose level, BMI and abdominal girth also were considered. The Pearson or Spearman correlation coefficients were used respectively, with p < 0.05 and 95% CI. Results: SOD had a correlation with fast walking (r = 0.6) and moving time (r = 0.6). AOPP had a correlation with fast walking (r = -0.4), slow walking (r = -0.5), standing (r = -0.4), moving (r = -0.4) and the lying time (r = 0.5). BMI had a correlation with moving time (r = -0.4). Glucose had a correlation with fast walking (-r = 0.63), standing (r = -0.5), moving (r = -0.6), slow walking (r = -0.61) and lying time (r = 0.54). Conclusions: increased levels of physical activity in daily life are significantly associated with greater antioxidant capacity, lower oxidative stress, glucose and BMI. MÉD.UIS.2020;33(1): 13-9.

https://doi.org/10.18273/revmed.v33n1-2020002 428 downloads

Participación social, un factor a considerar en la evaluación clínica del adulto mayor: una revisión narrativa
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Sepúlveda-Loyola, Walter

; Dos Santos Lopes, Rosielma

; Tricanico Maciel, Renata Pires

; Suziane Probst, Vanessa

Revista Peruana de Medicina Experimental y Salud Publica

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apr 2020, Volume 37 N. 2 Pages 341 - 349

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

https://doi.org/10.17843/rpmesp.2020.372.4518

Comment on the study Coronary Artery Bypass Surgery in Brazil: Analysis of the National Reality Through the Bypass Registry that was presented at the 46th Congress of the Brazilian Society of Cardiovascular Surgery, Nova Lima, BH, Brazil, April 5 and 6, 2019
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Dallan, Luís Alberto O.

; Paez, Rodrigo Pereira

; Hossne Junior, Nelson Américo

; Santo, José Amalth do Espírito

; Berwanger, Otavio

; Santos, Renato Hideo Nakagawa

; Kalil, Renato Abdala Karam

; Jatene, Fabio B.

; Cavalcanti, Alexandre Biasi

; Zilli, Alexandre Cabral

; Bettiati Jr, Luiz Carlos

; Figueira, Fernando Augusto Marinho dos Santos

; D’Azevedo, Stephanie Steremberg Pires

; Soares, Marcelo José Ferreira

; Fernandes, Marcio Pimentel

; Ardito, Roberto Vito

; Bogdan, Renata Andrea Barberio

; Campagnucci, Valquíria Pelisser

; Nakasako, Diana

; Rodrigues, Clarissa Garcia

; Rodrigues Junior, Anilton Bezerra

; Cascudo, Marcelo Matos

; Atik, Fernando Antibas

; Lima, Elson Borges

; Nina, Vinicius José da Silva

; Heluy, Renato Albuquerque

; Azeredo, Lisandro Gonçalves

; Henrique Junior, Odilon Silva

; Mendonça, José Teles de

; Silva, Katharina Kelly de Oliveira Gama

; Pandolfo, Marcelo

; Lima Júnior, José Dantas de

; Faria, Renato Max

; Santos, Jonas Gonçalves dos

; Coelho, Guilherme Henrique Biachi

; Pereira, Sergio Nunes

; Senger, Roberta

; Buffolo, Enio

; Caputi, Guido Marco

; Oliveira, Juliana Aparecida Borges de

; Gomes, Walter J.

Brazilian Journal of Cardiovascular Surgery

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aug 2019, Volume 34 N. 4 Pages 504 - 506

Abstract: En | Text: En | PDF: En

https://doi.org/10.21470/1678-9741-2019-0606 335 downloads

Coronary Artery Bypass Surgery in Brazil: Analysis of the National Reality Through the BYPASS Registry
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Paez, Rodrigo Pereira

; Hossne Junior, Nelson Américo

; Santo, José Amalth do Espírito

; Berwanger, Otavio

; Santos, Renato Hideo Nakagawa

; Kalil, Renato Abdala Karam

; Jatene, Fabio B.

; Cavalcanti, Alexandre Biasi

; Zilli, Alexandre Cabral

; Bettiati Jr, Luiz Carlos

; Figueira, Fernando Augusto Marinho dos Santos

; D'Azevedo, Stephanie Steremberg Pires

; Soares, Marcelo José Ferreira

; Fernandes, Marcio Pimentel

; Ardito, Roberto Vito

; Bogdan, Renata Andrea Barberio

; Campagnucci, Valquíria Pelisser

; Nakasako, Diana

; Rodrigues, Clarissa Garcia

; Rodrigues Junior, Anilton Bezerra

; Cascudo, Marcelo Matos

; Atik, Fernando Antibas

; Lima, Elson Borges

; Nina, Vinicius José da Silva

; Heluy, Renato Albuquerque

; Azeredo, Lisandro Gonçalves

; Henrique Junior, Odilon Silva

; Mendonça, José Teles de

; Silva, Katharina Kelly de Oliveira Gama

; Pandolfo, Marcelo

; Lima Júnior, José Dantas de

; Faria, Renato Max

; Santos, Jonas Gonçalves dos

; Coelho, Guilherme Henrique Biachi

; Pereira, Sergio Nunes

; Senger, Roberta

; Buffolo, Enio

; Caputi, Guido Marco

; Oliveira, Juliana Aparecida Borges de

; Gomes, Walter J.

Brazilian Journal of Cardiovascular Surgery

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apr 2019, Volume 34 N. 2 Pages 142 - 148

Abstract: En | Text: En | PDF: En

Abstract Introduction: Coronary artery bypass grafting (CABG) is the most frequently performed heart surgery in Brazil. Recent international guidelines recommend that national societies establish a database on the practice and results of CABG. In anticipation of the recommendation, the BYPASS Registry was introduced in 2015. Objective: To analyze the profile, risk factors and outcomes of patients undergoing CABG in Brazil, as well as to examine the predominant surgical strategy, based on the data included in the BYPASS Registry. Methods: A cross-sectional study of 2292 patients undergoing CABG surgery and cataloged in the BYPASS Registry up to November 2018. Demographic data, clinical presentation, operative variables, and postoperative hospital outcomes were analyzed. Results: Patients referred to CABG in Brazil are predominantly male (71%), with prior myocardial infarction in 41.1% of cases, diabetes in 42.5%, and ejection fraction lower than 40% in 9.7%. The Heart Team indicated surgery in 32.9% of the cases. Most of the patients underwent cardiopulmonary bypass (87%), and cardioplegia was the strategy of myocardial protection chosen in 95.2% of the cases. The left internal thoracic artery was used as a graft in 91% of the cases; the right internal thoracic artery, in 5.6%; and the radial artery in 1.1%. The saphenous vein graft was used in 84.1% of the patients, being the only graft employed in 7.7% of the patients. The median number of coronary vessels treated was 3. Operative mortality was 2.8%, and the incidence of cerebrovascular accident was 1.2%. Conclusion: CABG data in Brazil provided by the BYPASS Registry analysis are representative of our national reality and practice. This database constitutes an important reference for indications and comparisons of therapeutic procedures, as well as to propose subsequent models to improve patient safety and the quality of surgical practice in the country.

https://doi.org/10.21470/1678-9741-2018-0313 1270 downloads

‘Sobre o conceito da História’ na saúde coletiva
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Mendonça, André Luis de Oliveira

; Gonçalves, Leandro Augusto Pires

Saúde em Debate

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2019, Volume 43 N. spe8 Pages 203 - 218

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Nesse ensaio, cujo título é inspirado na pequena obra-prima ‘Sobre o conceito da História’, de Walter Benjamin, narra-se a história da saúde coletiva, em conexão com o ser social brasileiro, por meio de doze teses concatenadas e, concomitantemente, independentes entre si; mais precisamente, dadas as divergências pontuais entre os autores, pode-se dizer que o texto apresenta teses e, por assim dizer, algumas antíteses. Sem deixar de reconhecer a relevância que o campo da saúde coletiva e o Movimento Sanitarista possuem nos rumos da saúde pública e da sociedade brasileira, encadeia-se o argumento de que ambos não ficaram imunes àquilo que se cunha aqui de SER (Sexismo, Elitismo e Racismo) - modo de ser constitutivo da modernidade e do ocidente -, responsável pelo não ser da maioria dita ‘minorias’, sobretudo dos cinco ‘pês’ de periferias: pobres, pretos, ‘psicóticos’, ‘putas’ e ‘paraíbas’. Para fundamentar essa tese (ou teses), os autores irmanam-se, cada um à sua maneira, ao conhecimento cultivado e ofertado por intelectuais negras e negros, bem como a autoras e autores que contribuem para a descolonização dos saberes e práticas, incluindo alguns europeus, em direção à libertação coletiva.

ABSTRACT In this essay, whose title is inspired by the master piece ‘On the concept of the History’ by Walter Benjamin, we tell the history of the collective health, in connection to the Brazilian social human being, through twelve theses concatenated and concomitantly independent among them, precisely given some pointed divergences among us - the authors. We can say that the text presents theses and therefore some antitheses. We do acknowledge the relevance that the field of the collective health and the Sanitarian Movement have in the collective health and the Brazilian society; we linked the argument that both would not be immune to that which we here called: SER (Sexism, Elitism, Racism) - a way of being constitutive of our western and modern society -, responsible for the not-being of the majority which is called minority, mainly of the 5 archetypes of the Outskirts: ‘the Poor, the Black, the Psychotic, the Prostitute, the Northeastern’. To ground this thesis (or theses), we fraternized ourselves, each one to his\her way, to the provided and cultivated knowledge by the black scholars as well as the authors who contribute to the decolonization of our knowledge and practices, including some Europeans, towards collective emancipation.

https://doi.org/10.1590/0103-11042019s815 394 downloads

‘Sobre o conceito da História’ na saúde coletiva
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Mendonça, André Luis de Oliveira

; Gonçalves, Leandro Augusto Pires

Saúde em Debate

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2019, Volume 43 N. spe8 Pages 203 - 218

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

https://doi.org/10.1590/0103-11042019s815

Brazilian assessment on biodiversity and ecosystem services: summary for policy makers
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Joly, Carlos A.

; Scarano, Fabio R.

; Bustamante, Mercedes

; Gadda, Tatiana Maria Cecy

; Metzger, Jean Paul Walter

; Seixas, Cristiana Simão

; Ometto, Jean Pierre HB

; Pires, Aliny Patrícia Flauzino

; Boesing, Andrea Larissa

; Sousa, Francisco Diogo Rocha

; Quintão, José Maurício Brandão

; Gonçalves, Leandra Regina

; Padgurschi, Maíra de Campos Gorgulho

; Aquino, Michely Ferreira dos Santos de

; Castro, Paula Felício Drummond de

; Santos, Isabela Lima dos

Biota Neotropica

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2019, Volume 19 N. 4 elocation e20190865

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo: A biodiversidade e os ecossistemas são elementos importantes para enfrentar as crises socioeconômicas e ambientais nacionais e globais, uma vez que proporcionam novas oportunidades de desenvolvimento. Incorporar a biodiversidade na vida cotidiana é uma oportunidade de ouro para promover o uso sustentável da biodiversidade e dos serviços ecossistêmicos. A conservação e a restauração da biodiversidade, dos ecossistemas e de seus serviços associados mostram potencial para um novo desenvolvimento social e econômico, como fonte de geração de emprego e renda, redução da pobreza e da desigualdade socioeconômica. A diversidade biológica brasileira também se expressa em sua imensa diversidade cultural, com uma grande variedade de detentores de conhecimento indígenas e tradicionais. Esses povos possuem vasto conhecimento sobre agrobiodiversidade, pesca, manejo do fogo, medicina natural, entre outros de valor comercial, cultural e espiritual. As principais conclusões deste Sumário para Tomadores de Decisão é que as mudanças no uso da terra e as mudanças climáticas tenham sido - e continuarão sendo ao longo deste século - os principais vetores da perda de biodiversidade e serviços ecossistêmicos no país. Intervenções políticas em diferentes níveis (do local ao nacional, do público ao privado) e a aplicação das leis existentes (mecanismos regulatórios e incentivos) são necessárias para promover a mitigação dos impactos negativos sobre a biodiversidade e a perda de serviços ecossistêmicos. O Brasil já possui uma ampla variedade de instrumentos de política e opções de governança socioambiental, bem como compromissos globais (ODS, Metas de Aichi, Acordo de Paris) relacionados à possibilidade de um futuro sustentável. Entretanto, o controle ineficiente da gestão ou a falta de incentivo para cumprir as regras traz riscos para a consolidação do caminho para esse futuro. O país tem instituições fortes e capazes, mas problemas de infraestrutura, processos lentos, medidas ineficazes e conflitos judiciais, sociais e ecológicos impedem a realização de um desempenho eficiente. Há uma falta de comunicação entre a ciência e a sociedade que precisa ser melhorada por meio do estabelecimento de um fluxo efetivo que torne a comunicação inclusiva e representativa, alcançando os tomadores de decisão públicos e privados. Esforços permanentes para integrar essas duas esferas de conhecimento na sociedade são desejáveis para criar confiança entre os formuladores de políticas e os pesquisadores.

Abstract: Biodiversity and ecosystems are important elements for addressing national and global socioeconomic and environmental crises, since they provide new development opportunities, for example, as source of job and income creation, and reduction in poverty and socioeconomic inequity. Brazilian biological diversity is also expressed in its immense cultural diversity, with a great variety of knowledge holders. These peoples possess vast knowledge on agrobiodiversity, fishing, fire management, natural medicine, among others of commercial, cultural and spiritual value. The main conclusions of this Summary for Police Makers is that land use changes and climate changes have been - and will continue to be throughout this century - the main drivers that result in the loss of biodiversity and ecosystem services in the country. Political interventions at different levels (from local to national, from public to private) and the enforcement of existing laws (regulatory mechanisms and incentives) are required to cope with the mitigation of the negative impacts of biodiversity and ecosystem services loss. Brazil has already a wide variety of policy instruments and socioenvironmental governance options, as well as global commitments (ODS, Aich Targets, Paris Agreement) related to the objective of a sustainable future. However, inefficient management control or lack of incentive to comply with the rules pose risks to consolidating the path to this future. The country has strong and capable institutions, but infrastructural problems, slow processes, inefficient measurements and judicial, social and ecological conflicts obstruct a proficient performance. There is a lack of communication between science and society which needs to be improved by establishing an effective flow that makes communication inclusive and representative, reaching public and private decision makers. Permanent efforts to integrate Science and policy knowledges are desirable to build confidence between policy makers and researchers.

https://doi.org/10.1590/1676-0611-bn-2019-0865 3811 downloads

10.

Study of Glass Forming on Cu60.0Zr32.5Ti7.5 Alloy by Molecular Dynamics Simulation
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Aliaga, Luis César Rodríguez

; Schimidt, Camila Sanches

; Lima, Lucas Venancio Pires de Carvalho

; Bastos, Ivan Napoleão

; Botta, Walter José

Materials Research

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2018, Volume 21 N. 2 elocation e20170555

Abstract: En | Text: En | PDF: En

This paper presents the results of Molecular Dynamics (MD) simulations of Cu60.0Zr32.5Ti7.5 alloy through the open source code LAMMPS. Amorphous samples were produced by quenching the molten metal from 2300 to 300 K. The pair distribution functions of the liquid and solid were calculated. Moreover, the atomic short-range order at 800, 700 and 300 K was obtained by using the Voronoi tesselation method. Cu-centered icosahedral clusters were the prevailing configuration. The tensile stress-strain curve showed that the material present plastic deformation, however, shear bands were not observed in the MD simulation. The evolution of viscosity in temperatures higher than its glass transition temperature was also determined. Furthermore, the fragility of the alloy at glass temperature was evaluated.

https://doi.org/10.1590/1980-5373-mr-2017-0555 1184 downloads

11.

Qualitative analysis of the viability of autogenous fat grafts grafted in different environments of interstitial pressure. Preliminary results and description of a new experimental model in mini-pigs
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Arruda, Eduardo Gustavo Pires de

; Munhoz, Alexandre Mendonça

; Matsumoto, Walter

; Ueda, Thiago

; Coudry, Renata de Almeida

; Gemperli, Rolf

Acta Cirúrgica Brasileira

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nov 2017, Volume 32 N. 11 Pages 891 - 902

Abstract: En | Text: En | PDF: En

Abstract Purpose: To evaluate the feasibility of an experimental model of autologous fat graft (AFG) in different interstitial pressure (IP) environments. Methods: Three mini-pigs(Minipig-BR) with age of 8 months (weight: 25-30 kg) were used. AFG were collected from the bucal fat pad, and grafted in the intramuscular pocket (biceps femoralis muscle). IP model was based on a fusiform ressection followed by primary closure “under tension”. A blood pressure catheter located in the intramuscular region connected to a pressure module was applied to quantify IP. Results: The mean operative time was 236 min (210 - 272 min). All the AFG and muscular segments were removed successfully. Average interstitial pressure CP and H were 3 and 10.6 mmHg respectively. The AFG were biopsied for histopathological analysis 30 days after graft. Hematoxylin-eosin staining and immunohistochemical analyzes (TNF-alpha, CD31 and Perilipine with monoclonal antibodies) were employed. Conclusion: The data show that minipigs model could be used as a recipient site for autologous fat graft techniques and allow the development of studies to explore the AFG intake and pathophysiology response.

https://doi.org/10.1590/s0102-865020170110000001 1145 downloads

12.

The Brazilian Registry of Adult Patient Undergoing Cardiovascular Surgery, the BYPASS Project: Results of the First 1,722 Patients
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Gomes, Walter J.

; Moreira, Rita Simone

; Zilli, Alexandre Cabral

; Bettiati Jr, Luiz Carlos

; Figueira, Fernando Augusto Marinho dos Santos

; D' Azevedo, Stephanie Steremberg Pires

; Soares, Marcelo José Ferreira

; Fernandes, Marcio Pimentel

; Ardito, Roberto Vito

; Bogdan, Renata Andrea Barberio

; Campagnucci, Valquíria Pelisser

; Nakasako, Diana

; Kalil, Renato Abdala Karam

; Rodrigues, Clarissa Garcia

; Rodrigues Junior, Anilton Bezerra

; Cascudo, Marcelo Matos

; Atik, Fernando Antibas

; Lima, Elson Borges

; Nina, Vinicius José da Silva

; Heluy, Renato Albuquerque

; Azeredo, Lisandro Gonçalves

; Henrique Junior, Odilon Silva

; Mendonça, José Teles de

; Silva, Katharina Kelly de Oliveira Gama

; Pandolfo, Marcelo

; Lima Júnior, José Dantas de

; Faria, Renato Max

; Santos, Jonas Gonçalves dos

; Paez, Rodrigo Pereira

; Coelho, Guilherme Henrique Biachi

; Pereira, Sergio Nunes

; Senger, Roberta

; Buffolo, Enio

; Caputi, Guido Marco

; Santo, José Amalth do Espírito

; Oliveira, Juliana Aparecida Borges de

; Berwanger, Otavio

; Cavalcanti, Alexandre Biasi

; Jatene, Fabio B.

Brazilian Journal of Cardiovascular Surgery

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apr 2017, Volume 32 N. 2 Pages 71 - 76

Abstract: En | Text: En | PDF: En

Abstract Objective: To report the early results of the BYPASS project - the Brazilian registrY of adult Patient undergoing cArdiovaScular Surgery - a national, observational, prospective, and longitudinal follow-up registry, aiming to chart a profile of patients undergoing cardiovascular surgery in Brazil, assessing the data harvested from the initial 1,722 patients. Methods: Data collection involved institutions throughout the whole country, comprising 17 centers in 4 regions: Southeast (8), Northeast (5), South (3), and Center-West (1). The study population consists of patients over 18 years of age, and the types of operations recorded were: coronary artery bypass graft (CABG), mitral valve, aortic valve (either conventional or transcatheter), surgical correction of atrial fibrillation, cardiac transplantation, mechanical circulatory support and congenital heart diseases in adults. Results: 83.1% of patients came from the public health system (SUS), 9.6% from the supplemental (private insurance) healthcare systems; and 7.3% from private (out-of -pocket) clinic. Male patients comprised 66%, 30% were diabetics, 46% had dyslipidemia, 28% previously sustained a myocardial infarction, and 9.4% underwent prior cardiovascular surgery. Patients underwent coronary artery bypass surgery were 54.1% and 31.5% to valve surgery, either isolated or combined. The overall postoperative mortality up to the 7th postoperative day was 4%; for CABG was 2.6%, and for valve operations, 4.4%. Conclusion: This first report outlines the consecution of the Brazilian surgical cardiac database, intended to serve primarily as a tool for providing information for clinical improvement and patient safety and constitute a basis for production of research protocols.

https://doi.org/10.21470/1678-9741-2017-0053 1883 downloads

13.

Conceitos básicos sobre a física da formação de tubos de fluxo magnético nas proximidades da Terra
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Ferreira, Pedro Pires

; Silveira, Marcos Vinicius Dias

; Cardoso, Flavia Reis

; Koga, Daiki

; Souza, Vitor Moura Cardoso e Silva

; Vieira, Luis Eduardo Antunes

; Pérez, Germán Fariñas

; Cuadros-Melgar, Bertha M.

; Gonzalez, Walter D.

; Santos, Eduardo Ferro dos

Revista Brasileira de Ensino de Física

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2017, Volume 39 N. 2 elocation e2307

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Em 1978 Christopher T. Russell e Richard C. Elphic detectaram tubos de fluxo magnético na região de fronteira da magnetosfera terrestre por meio de dados observacionais obtidos pelos satélites ISEE-1 e −2, que foram denominados eventos de transferência de fluxo, ou simplesmente FTE (do inglês, flux transfer events). O vento solar, juntamente com o campo magnético interplanetário, oriundos do Sol, atingem a região de campo magnético terrestre, produzindo fenômenos como a reconexão magnética e os tubos de fluxo. Esse artigo apresenta uma introdução sobre a conexão Sol-Terra e o processo de reconexão magnética, e principalmente, os conceitos básicos sobre a geração e a formação dos tubos de fluxo magnético. Os modelos que descrevem o tipo de reconexão e as características dos tubos, como por exemplo Russell-Elphic, Lee-Fu e Southwood-Scholer, e as propriedades dos eventos FTE, são apresentados de forma clara e concisa. Por fim, o artigo trata de um exemplo de identificação dos tubos em simulação computacional, realizado nesse trabalho.

In 1978 Christopher T. Russell and Richard C. Elphic detected magnetic flux tubes in magnetosphere boundary region through observational data obtained from the satellites ISEE-1 and −2, which were named flux transfer events (FTE). The solar wind together with the interplanetary magnetic field, both originated in the Sun, reach the earth magnetic field region, producing the magnetic reconnection and the flux tubes phenomena. This paper presents an introduction on the Sun-Earth connection and the magnetic reconnection process, and mainly the basic concepts on the tubes generation and formation. The models which describe the type of reconnection and the tubes signatures, for example, Russell-Elphic, Lee-Fu, Southwood-Scholer, and the FTE event characteristics, are presented in a clear and concise way. Finally, this paper brings an example of the tubes identification in computing simulation, performed in this work.

https://doi.org/10.1590/1806-9126-rbef-2016-0190 2505 downloads

14.

Impact of chronic urticaria on the quality of life of patients followed up at a university hospital
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Dias, Gabriela Andrade Coelho

; Pires, Gisele Viana

; Valle, Solange Oliveira Rodrigues do

; Dortas Júnior, Sérgio Duarte

; Levy, Soloni

; França, Alfeu Tavares

; Baiardini, Ilaria

; Canonica, Walter Giorgio

Anais Brasileiros de Dermatologia

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dec 2016, Volume 91 N. 6 Pages 754 - 759

Abstract: En | Text: En | PDF: En

Abstract BACKGROUND: Chronic urticaria is a debilitating disease that considerably affects health-related quality of life, and the Chronic Urticaria Quality of Life Questionnaire is the only questionnaire specifically designed for its evaluation. OBJECTIVE: To evaluate the quality of life of patients with chronic urticaria, using the Brazilian Portuguese version of the Chronic Urticaria Quality of Life Questionnaire. METHODS: The Chronic Urticaria Quality of Life Questionnaire was self-administered in 112 chronic urticaria patients and disease activity was assessed through the Urticaria Activity Score. Clinical and socio-demographic characteristics of patients were studied, such as: age, sex, etiologic diagnosis of chronic urticaria, duration of disease and Urticaria Activity Score. RESULTS: The population studied was composed 85.72% of women with a mean age of 46 years (18-90), while the median disease duration period was 10 years (3 months-60 years). Regarding the etiologic diagnosis, 48.22% had chronic spontaneous urticaria; 22.32% associated with inducible urticaria, 28.57% with chronic autoimmune urticaria, and 23.21% had physical urticaria alone. Disease activity evaluated using the Urticaria Activity Score was 1.04 ± 1.61 (0-6). The total score for the Chronic Urticaria Quality of Life Questionnaire was 36 (0-100) and dimension I (sleep/mental status/eating) had a greater impact on quality of life. The items with the highest mean scores were nervousness and shame over lesions, while the items with the lowest scores were lip swelling and limitations on sporting activities. CONCLUSIONS: Chronic urticaria compromises patients' quality of life, mainly those with more severe disease or who are diagnosed with chronic autoimmune urticaria.

https://doi.org/10.1590/abd1806-4841.20165071 1882 downloads

15.

Influência da temperatura de extrusão nas propriedades reológicas do bioplástico de glúten de trigo
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Ferreira, Shana Pires

; Ruiz, Walter Augusto

; Gaspar-Cunha, António

Revista de Ciências Agrárias

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mar 2014, Volume 37 N. 1 Pages 10 - 19

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

O objetivo deste trabalho foi estudar a influência das diferentes condições de extrusão nas propriedades térmicas e reológicas de biopolímeros de glúten de trigo plastificado com glicerol. A temperatura das zonas de aquecimento da extrusora co-rotativa de parafuso duplo influi nas propriedades térmicas e reológicas dos biopolímeros. Temperaturas entre 55 ºC e 60 ºC produziram extrusados de bom aspecto e pouca rugosidade. Os extrusados apresentaram elevados valores de G’ e G’’ e a modelagem do processo de extrusão mostrou que a mudança na configuração das zonas de aquecimento influencia principalmente na localização da deformação ao longo da extrusora.

The main objective of this work was to study the influence of different extrusion conditions on thermal and rheological properties of biopolymers of wheat gluten plasticized with glycerol. The temperature of the heating zones of the extruder co-rotating twin screw influences the rheological and thermal properties of biopolymers. Temperatures between 55 ºC and 60 ºC produced extrudates with good looks and low roughness. The extrudates showed high values of G’ and G’’ and shaping the extrusion process showed that the change in configuration of the heating zones mainly influences the location of the deformation along the extruder.

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