ABSTRACT Malnutrition/sarcopenia is frequent in patients with inflammatory bowel diseases (IBD), and results in muscle catabolism, impacting treatment response, postoperative complications, and quality of life. Objective: This study aims to assess whether the phase angle (PhA) is a parameter for predicting reduced muscle mass in patients with IBD. Methods: Adult patients with IBD were included in this cross-sectional study. For the estimation of muscle mass and the calculation of the PhA, we used bioelectrical impedance analysis (BIA). Crohn’s disease (CD) and ulcerative colitis (UC) activity scores were defined using the Harvey-Bradshaw index and partial Mayo score, respectively. The area under the ROC curve was calculated to identify the PhA cut-off point for reduced muscle mass. Results: The sample consisted of 145 patients, with 39 (26.9%) with IBD in the active phase. There was a correlation of the PhA with skeletal muscle mass (SMM) (rs 0.35, P<0.001) and with the skeletal muscle mass index (SMI) (rs 0.427, P<0.001), and the associations remained in the most active form (moderate or severe) of IBD. The ROC curve analysis indicated that the cut-offs points of the PhA ≤5.042 for female and PhA ≤6.079 for male can be used to predict muscle mass reduction. Conclusion: The PhA can be considered a predictor of muscle mass reduction in IBD patients, and we can use it for screening and monitoring the evolution of malnutrition. Malnutritionsarcopenia Malnutrition sarcopenia IBD, , (IBD) catabolism response complications life Objective (PhA Methods crosssectional cross sectional BIA. BIA . (BIA) Crohns Crohn s CD (CD UC (UC HarveyBradshaw Harvey Bradshaw score respectively cutoff cut off Results 14 3 26.9% 269 26 9 (26.9% SMM (SMM rs 035 0 35 0.35 P<0.001 P0001 P 001 SMI (SMI 0427 427 0.427 P<0.001, moderate severe cutoffs offs 5042 5 042 ≤5.04 6079 6 079 ≤6.07 Conclusion malnutrition (IBD (BIA 1 26.9 2 (26.9 03 0.3 P<0.00 P000 00 42 0.42 504 04 ≤5.0 607 07 ≤6.0 26. (26. 0. P<0.0 P00 4 0.4 50 ≤5. 60 ≤6. (26 P<0. P0 ≤5 ≤6 (2 P<0 ≤ ( P<

RESUMO A desnutrição/sarcopenia é frequente em pacientes com doenças inflamatórias intestinais (DII), resultando em catabolismo muscular, com impacto nas respostas aos tratamentos, complicações cirúrgicas e na qualidade de vida. Objetivo: Este estudo tem como objetivo, avaliar se o ângulo de fase (AF) é um parâmetro para a predição de redução de massa muscular em pacientes com DII. Métodos: Pacientes adultos com DII foram incluídos neste estudo transversal. A estimativa da massa muscular e o cálculo do AF foram realizados a partir do exame de bioimpedância elétrica (BIA). As atividades da doença de Crohn e retocolite ulcerativa foram definidas pelo índice Harvey-Bradshaw e escore parcial de Mayo, respectivamente. A área de curva ROC foi calculada para identificar o ponto de corte do AF para a massa muscular reduzida. Resultados: A amostra foi composta por 145 pacientes, sendo 39 (26.9%) com DII em fase ativa. Houve correlação do AF com massa muscular esquelética (MME) (rs 0.35, P<0.001) e com o índice de massa muscular esquelética (IMME) (rs 0.427, P<0.001), mantendo-se as associações na forma mais ativa (moderada ou grave) da DII. A análise da curva ROC indicou que os pontos de corte de AF ≤5.042 para mulheres e ≤6.079 para homens podem ser usados para prever a redução da massa muscular. Conclusão: O AF pode ser considerado um preditor de redução de massa muscular nos pacientes com DII e ser utilizado para triagem e acompanhamento da evolução da desnutrição. desnutriçãosarcopenia desnutrição sarcopenia DII, , (DII) tratamentos vida Objetivo objetivo (AF Métodos transversal BIA. BIA . (BIA) HarveyBradshaw Harvey Bradshaw Mayo respectivamente reduzida Resultados 14 3 26.9% 269 26 9 (26.9% MME (MME rs 035 0 35 0.35 P<0.001 P0001 P 001 IMME (IMME 0427 427 0.427 P<0.001, mantendose mantendo moderada grave 5042 5 042 ≤5.04 6079 6 079 ≤6.07 Conclusão (DII (BIA 1 26.9 2 (26.9 03 0.3 P<0.00 P000 00 42 0.42 504 04 ≤5.0 607 07 ≤6.0 26. (26. 0. P<0.0 P00 4 0.4 50 ≤5. 60 ≤6. (26 P<0. P0 ≤5 ≤6 (2 P<0 ≤ ( P<

Abstract The present study aimed to investigate the contextual inequalities of specialized public dental care (SPDC) in Brazil. The outcome was the trajectory of dental specialized production in municipalities with SPDC (from 2015 to 2017) obtained by group-based trajectory modeling. A Poisson regression model was used to analyze the factors associated with the high trajectory of SPDC production. The inequality indicators for SPDC production were the slope index and the concentration index according to contextual factors. The study included 954 SPDC units distributed across 893 municipalities. Among the municipalities evaluated, 62.9% had a low trajectory of SPDC. Large-sized municipalities had the highest production (IRR = 2.84, 95%CI: 1.94–4.14) and the southern region had the lowest production (IRR = 0.73, 95%CI: 0.58–0.92). Municipalities presenting a very high human development index (HDI) showed the greatest SPDC production (IRR = 3.34, 95%CI: 1.09–10.24), as well as municipalities with the highest tertile of schooling rate (IRR = 1.23, 95%CI: 1.00–1.50). The absolute inequality was 52.1 percentage points for the average monthly wage (p < 0.001), 61.0 percentage points for the HDI (p < 0.001), -22.1 for infant mortality rate (p <0.001), and 14.8 for the schooling rate (p = 0.012). Thus, there are contextual inequalities in the Brazilian SPDC. Higher scores for social indicators were associated with better SPDC performance. (SPDC Brazil from 201 2017 groupbased group based modeling 95 89 evaluated 629 62 9 62.9 Largesized Large sized IRR 284 2 84 2.84 95%CI 95CI CI 1.94–4.14 194414 1 94 4 14 073 0 73 0.73 0.58–0.92. 058092 0.58–0.92 . 58 92 0.58–0.92) (HDI 334 3 34 3.34 1.09–10.24, 1091024 1.09–10.24 , 09 10 24 1.09–10.24) 123 23 1.23 1.00–1.50. 100150 1.00–1.50 00 50 1.00–1.50) 521 52 52. p 0.001, 0001 0.001 001 0.001) 610 61 61. 22.1 221 22 -22. <0.001, <0.001 <0.001) 148 8 14. 0.012. 0012 0.012 012 0.012) Thus performance 20 6 62. 28 2.8 1.94–4.1 19441 07 7 0.7 05809 0.58–0.9 5 33 3.3 109102 1.09–10.2 12 1.2 10015 1.00–1.5 000 0.00 22. -22 <0.00 0.01 01 2. 1.94–4. 1944 0. 0580 0.58–0. 3. 10910 1.09–10. 1. 1001 1.00–1. 0.0 -2 <0.0 1.94–4 194 058 0.58–0 1091 1.09–10 100 1.00–1 - <0. 1.94– 19 05 0.58– 109 1.09–1 1.00– <0 1.94 0.58 1.09– 1.00 1.9 0.5 1.09 1.0

ABSTRACT The objective of this study was to evaluate the effects of prebiotics, alone and in combination with antibiotics, on broiler performance, carcass yield, intestinal permeability, and intestinal morphometry. A total of 1440 day-old male Cobb 500 chicks were distributed in a completely randomized design, with four treatments and 10 replications per treatment. The treatments used were a basal diet without prebiotics and antibiotics (BD), a basal diet with antibiotics (AB), a basal diet with prebiotics (PRE), and a basal diet with antibiotics and prebiotics (AB+PRE). To perform the treatment, the antibiotic zinc bacitracin and a prebiotic of S. cerevisiae-derived mannan-oligosaccharides and beta-glucans were used. The treatments did not affect the performance of birds from 1 to 7 and 1 to 21 days of age. From 1 to 35 and 1 to 42 days, birds fed the AB+PRE treatment had higher feed intake than those fed the AB treatment. From 1 to 35 days, birds fed the AB+PRE treatment showed a worse feed conversion ratio. However, there was no difference in carcass yield between treatments. A higher number of goblet cells was observed in the duodenum and ileum of birds fed AB+PRE, but lower counts were obtained in birds fed AB. Intestinal histomorphometry displayed similar responses between both ages regarding antibiotic and prebiotic treatments, except in the ileum at 42 days, in which the antibiotic elicited a better response. Intestinal permeability analysis showed no significant difference between diets. The use of prebiotics, alone or in combination with antibiotics, does not improve the performance of broilers. morphometry 144 dayold day old 50 design BD, BD , (BD) AB, (AB) PRE, PRE (PRE) AB+PRE. ABPRE . (AB+PRE) S cerevisiaederived cerevisiae derived mannanoligosaccharides mannan oligosaccharides betaglucans beta glucans 2 age 3 4 ratio However response diets broilers 14 5 (BD (AB (PRE (AB+PRE

Resumen La investigación agropecuaria y la extensión resultan clave para impulsar procesos de innovación y desarrollo rural. En este artículo nos proponemos analizar las concepciones de investigación, extensión y de su vinculación presentes en diversos documentos institucionales del INTA, principal institución argentina de innovación agropecuaria y desarrollo rural. El análisis muestra que las concepciones de investigación, extensión y del vínculo entre ellas presentes en los documentos institucionales se organizan a partir de dos modelos de innovación. Al primero, que se apoya en el positivismo, lo denominamos ‘difusionista contextualizado’. En él, si bien se valoran las necesidades y la retroalimentación de los productores, el conocimiento es producido por especialistas y transferido a los productores. En el modelo ‘territorial constructivista’ la innovación está relacionada con el aprendizaje social resultante de la interacción horizontal entre múltiples actores. En él se prioriza el conocimiento para la acción y la adaptación local de los conocimientos en el contexto de uso. Los documentos analizados no logran integrar ambos modelos, ya que basculan entre invisibilizar diferencias y considerarlos desde una perspectiva evolutiva que niega la legitimidad el difusionismo contextualizado. Destacamos la necesidad de reconocer los distintos modelos de innovación y elegir el más adecuado en cada contexto. rural INTA primero positivismo difusionista contextualizado . contextualizado’ productores territorial constructivista actores uso

Abstract Agricultural research and extension are key to promoting innovation and rural development processes. In this article, we analyze the conceptions of research, extension and their link present in different institutional documents of INTA, the main Argentine institution of agricultural innovation and rural development. The analysis shows that the conceptions of research, extension and the link among them present in the institutional documentation are organized around two different models of innovation. The first is based on positivism. We named it ‘contextualized transfer of technologies’. In it, although the needs and feedback of farmers are valued, the knowledge is produced by specialists and transferred to the producers. In the ‘territorial constructivist’ model, innovation is related to social learning resulting from the horizontal interaction among multiple actors. It prioritizes knowledge for action and the local adaptation of knowledge in the context of use. The analyzed documents fail to integrate both models, since they oscillate between making the differences invisible and considering them from an evolutionary perspective that denies the legitimacy of contextualized transfer of technologies. We highlight the need for recognizing the different models of innovation and choosing the most appropriate in each context. processes article INTA positivism technologies . technologies’ valued producers territorial constructivist model actors use

RESUMO Introdução: A implementação da Política Nacional de Saúde Integral de Lésbicas, Gays, Bissexuais, Travestis e Transexuais (PNSI-LGBTT) em 2011 e de outros marcos legais destaca a importância da inclusão da identidade de gênero e da orientação sexual na formação em saúde. Objetivo: Nesse contexto, o presente estudo tem como objetivo apresentar a presença da diversidade sexual e de gênero nas Diretrizes Curriculares Nacionais (DCN) dos cursos de graduação em saúde. Método: A coleta de dados foi realizada por meio de documentos de acesso público disponíveis no site do MEC. Examinaram-se 22 DCN estabelecidas nas últimas duas décadas, com foco nos registros de direitos humanos, identidade de gênero e orientação sexual. Resultado: Houve um aumento progressivo na inclusão das minorias sexuais nas DCN ao longo das duas últimas décadas, sobretudo nos últimos dez anos. Destaca-se um notável crescimento nos registros de direitos humanos, identidade de gênero e orientação sexual, refletindo uma mudança significativa no panorama das DCN. Conclusão: Os resultados evidenciam uma tendência positiva de inclusão de temas relacionados à diversidade sexual e de gênero nas DCN da área da saúde. Esse avanço sugere maior conscientização e reconhecimento da importância de uma formação inclusiva para profissionais de saúde, promovendo a equidade e a justiça social. Introdução Lésbicas Gays Bissexuais PNSILGBTT PNSI LGBTT (PNSI-LGBTT 201 saúde Objetivo contexto (DCN Método MEC Examinaramse Examinaram se 2 décadas humanos Resultado anos Destacase Destaca Conclusão social 20

ABSTRACT Introduction: The implementation of the National Policy for Comprehensive Health for Lesbians, Gays, Bisexuals, Transvestites and Transsexuals (PNSI-LGBTT) in 2011, together with other legal frameworks, highlights the importance of including Gender Identity and Sexual Orientation in health training. In this context, the present study aims to demonstrate the presence of sexual and gender diversity in the National Curricular Guidelines (DCN) of undergraduate health courses. Method: Data collection was carried out through publicly accessible documents available on the MEC website. Twenty-two DCNs established in the last two decades were assessed, focusing on records of Human Rights, Gender Identity and Sexual Orientation. Results: There has been a progressive increase in the inclusion of sexual minorities in the DCNs over the last two decades, especially in the last ten years. A notable growth in records of Human Rights, Gender Identity and Sexual Orientation stands out, reflecting a significant change in the panorama of curricular guidelines. Discussion: The results show a positive trend towards the inclusion of topics related to sexual and gender diversity in the DCNs in the health area. This advance suggests greater awareness and recognition of the importance of inclusive training for health professionals, promoting equity and social justice. Introduction Lesbians Gays Bisexuals PNSILGBTT PNSI LGBTT (PNSI-LGBTT 2011 frameworks context DCN (DCN courses Method website Twentytwo Twenty assessed Rights Results years guidelines Discussion area professionals justice 201 20 2

ABSTRACT This study aimed to identify factors associated with colonization by community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) in adult patients admitted to a Brazilian hospital. This is a cross-sectional study, in which patients underwent a nasal swab and were asked about hygiene behavior, habits, and clinical history. Among the 702 patients, 180 (25.6%) had S. aureus and 21 (2.9%) MRSA. The factors associated with MRSA colonization were attending a gym (OR 4.71; 95% CI; 1.42 – 15.06), smoking habit in the last year (OR 2.37; 95% CI; 0.88 – 6.38), previous hospitalization (OR 2.18; CI 95%; 0.89 – 5.25), and shared personal hygiene items (OR 1.99; 95% CI; 0.71 – 5.55). At the time of admission, colonization by CA-MRSA isolates was higher than that found in the general population. This can be an important public health problem, already endemic in hospitals, whose factors such as those associated with habits (smoking cigarettes) and behaviors (team sports practice and activities in gyms) have been strongly highlighted. These findings may help developing infection control policies, allowing targeting patients on higher-risk populations for MRSA colonization. communityassociated community methicillinresistant methicillin resistant CAMRSA CA (CA-MRSA hospital crosssectional cross sectional behavior history 70 18 25.6% 256 25 6 (25.6% S 2 2.9% 29 9 (2.9% OR 4.71 471 4 71 95 142 1 42 1.4 15.06, 1506 15.06 , 15 06 15.06) 2.37 237 37 088 0 88 0.8 6.38, 638 6.38 38 6.38) 2.18 218 089 89 5.25, 525 5.25 5 5.25) 1.99 199 99 071 0.7 5.55. 555 5.55 . 55 5.55) admission population problem hospitals cigarettes team gyms highlighted policies higherrisk risk 7 25.6 (25.6 2.9 (2.9 4.7 47 14 1. 150 15.0 2.3 23 3 08 8 0. 63 6.3 2.1 52 5.2 1.9 19 07 5.5 25. (25. 2. (2. 4. 15. 6. 5. (25 (2 (

ABSTRACT This study aimed to evaluate the effect of including an emulsifier (soybean lecithin) and two lipid sources (soybean oil and chicken fat) on the performance and intestinal morphology of broiler chickens. A total of 576 one-day-old Cobb® 500 male chicks were housed in a completely randomized design, with treatments divided in a 2 × 2 factorial arrangement (with and without emulsifier and two lipid sources – soybean oil or chicken fat), totaling four treatments with eight replications and 18 chicks per plot. The experimental diets were formulated to be isoenergetic and isoproteic. The use of chicken fat improved the live weight at the starter rearing stage. However, the use of the emulsifier improved the live weight at the grower and finisher phases. No interaction effect was observed between treatments for performance. The intestinal morphology showed an increase in duodenal villus height with the use of chicken fat and emulsifier. The ileum had an increase in villus height in chickens fed the diet with soybean oil and emulsifier. Supplementation of the emulsifier resulted in positive results in the live weight of chickens at 35 and 42 days of age, in addition to increasing the villus height in the small intestine. lecithin 57 onedayold one day old Cobb 50 design fat, , 1 plot isoproteic stage However phases 3 4 age intestine 5

ABSTRACT Asbestos was largely used in Brazil. It is a mineral that induces pleural and pulmonary fibrosis, and it is a potent carcinogen. Our objective was to develop recommendations for the performance of adequate imaging tests for screening asbestos-related diseases. We searched peer-reviewed publications, national and international technical documents, and specialists’ opinions on the theme. Based on that, the major recommendations are: Individuals exposed to asbestos at the workplace for ≥ 1 year or those with a history of environmental exposure for at least 5 years, all of those with a latency period > 20 years from the date of initial exposure, should initially undego HRCT of the chest for investigation. Individuals with pleural disease and/or asbestosis should be considered for regular lung cancer monitoring. Risk calculators should be adopted for lung cancer screening, with a risk estimate of 1.5%. Brazil fibrosis carcinogen asbestosrelated related diseases peerreviewed peer reviewed publications documents specialists theme are 2 investigation andor monitoring 15 1.5% 1.5 1.

Resumo: Este artigo estimou a prevalência da diabetes gestacional no Brasil. Foi realizada uma revisão sistemática e metanálise com artigos publicados de 2010 até 2021 nas bases de dados PubMed, Scopus, Google Scholar, SciELO, LILACS e Biblioteca Virtual em Saúde, além de literatura cinzenta. Os dados foram extraídos usando um instrumento padronizado juntamente com o instrumento de avaliação de risco de viés de Hoy et al. Posteriormente, foi desenvolvida uma metanálise com variância robusta e efeitos aleatórios. A heterogeneidade foi verificada pelo uso do I2 e o viés de publicação foi avaliado pelo gráfico de funil e pelo teste de Egger. Análises de subgrupos foram realizadas para determinar a prevalência de acordo com o risco de viés, critérios diagnósticos e regiões do país. Ao todo, 32 estudos foram incluídos nesta metanálise, totalizando 21.942 mulheres. A prevalência combinada de diabetes gestacional no Brasil foi de 14% (IC95%: 11,0; 16,0), consideravelmente superior às estimativas de estudos anteriores. Em relação ao risco de viés, estudos com baixo, médio e alto risco mostraram prevalência combinada de 12%, 14% e 14%, respectivamente. Em relação à certeza da evidência (abordagem GRADE), a classificação geral foi baixa. A maioria dos estudos utilizou os critérios do Grupo de Estudo da Associação Internacional de Diabetes na Gravidez (IADPSG) e do IADPSG adaptado, mostrando uma prevalência combinada de 15% e 14%, respectivamente. Em relação às regiões, a prevalência combinada foi maior no Sudeste (14%) e menor no Centro-oeste (9%). Esta foi a primeira revisão sistemática a fornecer evidências sobre a prevalência de diabetes gestacional em nível nacional, demonstrando considerável heterogeneidade entre os artigos e a influência da região, dos critérios diagnósticos e da qualidade dos estudos sobre o referido indicador. Resumo 201 202 PubMed Scopus Scholar SciELO Saúde cinzenta al Posteriormente aleatórios I Egger país todo 3 21942 21 942 21.94 mulheres 14 IC95% IC95 IC (IC95% 11,0 110 11 0 16,0, 160 16,0 , 16 16,0) anteriores baixo 12 12% respectivamente abordagem GRADE, GRADE GRADE) baixa (IADPSG adaptado 15 (14% Centrooeste Centro oeste 9%. 9 9% . (9%) nacional região indicador 20 2194 2 94 21.9 1 IC9 (IC95 11, 16, (14 (9% 219 21. (IC9 (1 (9 (IC (

Resumen: Este artículo estimó la prevalencia de diabetes gestacional en Brasil. Se realizó una revisión sistemática y metaanálisis con artículos publicados del 2010 al 2021 en las bases de datos PubMed, Scopus, Google Scholar, SciELO, LILACS y Biblioteca Virtual en Salud, además de literatura gris. Los datos se extrajeron usando un instrumento estandarizado junto con el instrumento de evaluación del riesgo de sesgo de Hoy et al. Posteriormente, se desarrolló un metaanálisis con varianza robusta y efectos aleatorios. La heterogeneidad se verificó mediante el I2, y el sesgo de publicación se evaluó por medio del gráfico en embudo y la prueba de Egger. Se realizaron análisis de subgrupos para determinar la prevalencia según el riesgo de sesgo, criterios diagnóstico y regiones del país. En total, se incluyeron 32 estudios en este metaanálisis, con un total de 21.942 mujeres. La prevalencia combinada de diabetes gestacional en Brasil fue del 14% (IC95%: 11,0; 16,0), considerablemente más alta que las estimaciones de estudios anteriores. Con relación al riesgo de sesgo, los estudios con riesgo bajo, medio y alto mostraron una prevalencia combinada del 12%, del 14% y del 14%, respectivamente. En cuanto a la certeza de la evidencia (enfoque GRADE), la clasificación general fue baja. La mayoría de los estudios utilizó los criterios del Grupo de Estudio de la Asociación Internacional de Diabetes en el Embarazo (IADPSG) y del IADPSG adaptado, lo que muestra una prevalencia combinada del 15% y del 14%, respectivamente. Con relación a las regiones, la prevalencia combinada fue mayor en el Sudeste (14%) y menor en el Centro-Oeste (9%). Esta fue la primera revisión sistemática que proporcionó evidencias sobre la prevalencia de diabetes gestacional en el ámbito nacional, lo que demuestra una considerable heterogeneidad entre los artículos y la influencia de la región, los criterios diagnósticos y la calidad de los estudios sobre este indicador. Resumen 201 202 PubMed Scopus Scholar SciELO Salud gris Posteriormente aleatorios I2 I Egger país 3 21942 21 942 21.94 mujeres 14 IC95% IC95 IC (IC95% 11,0 110 11 0 16,0, 160 16,0 , 16 16,0) anteriores bajo 12 12% respectivamente enfoque GRADE, GRADE GRADE) baja (IADPSG adaptado 15 (14% CentroOeste Centro Oeste 9%. 9 9% . (9%) nacional región indicador 20 2194 2 94 21.9 1 IC9 (IC95 11, 16, (14 (9% 219 21. (IC9 (1 (9 (IC (

Abstract: This study estimates gestational diabetes mellitus prevalence in Brazil. A systematic review was conducted with articles published between 2010 and 2021 on the PubMed, Scopus, Google Scholar, SciELO, LILACS and Virtual Health Library databases, as well as gray literature. Data were extracted using a standardized instrument together with the risk of bias assessment tool proposed by Hoy et al. A meta-analysis with robust variance and random effects was developed. Heterogeneity was verified using I2 and publication bias was assessed using funnel plot and Egger’s test. Prevalence according to risk of bias, diagnostic criteria and country’s regions was determined by subgroup analyses. A total of 32 studies were included, representing 21,942 women. gestational diabetes mellitus pooled prevalence was 14% (95%CI: 11.0; 16.0), considerably higher than estimates from previous studies. Regarding risk of bias, studies with low, medium, and high risk showed a pooled prevalence of 12%, 14% and 14%, respectively. Overall GRADE certainty of evidence rating was low. Most studies used the International Association of Diabetes in Pregnancy Study Group (IADPSG) criteria or the adapted IADPSG, showing a pooled prevalence of 15% and 14%, respectively. As for region, the pooled prevalence was higher in the Southeast (14%) and lower in the Central-West (9%). This is the first systematic review to provide evidence on gestational diabetes mellitus prevalence at a national level and to demonstrate considerable heterogeneity among articles and the influence of region, diagnostic criteria and study quality on the referred indicator. Abstract Brazil 201 202 PubMed Scopus Scholar SciELO databases literature al metaanalysis meta analysis developed I Eggers Egger s test countrys country analyses 3 included 21942 21 942 21,94 women 14 95%CI 95CI CI 95 (95%CI 11.0 110 11 0 16.0, 160 16.0 , 16 16.0) low medium 12 12% respectively IADPSG (IADPSG 15 region (14% CentralWest Central West 9%. 9 9% . (9%) indicator 20 2194 2 94 21,9 1 11. 16. (14 (9% 219 21, (1 (9 (

Resumen: Este artículo estimó la prevalencia de diabetes gestacional en Brasil. Se realizó una revisión sistemática y metaanálisis con artículos publicados del 2010 al 2021 en las bases de datos PubMed, Scopus, Google Scholar, SciELO, LILACS y Biblioteca Virtual en Salud, además de literatura gris. Los datos se extrajeron usando un instrumento estandarizado junto con el instrumento de evaluación del riesgo de sesgo de Hoy et al. Posteriormente, se desarrolló un metaanálisis con varianza robusta y efectos aleatorios. La heterogeneidad se verificó mediante el I2, y el sesgo de publicación se evaluó por medio del gráfico en embudo y la prueba de Egger. Se realizaron análisis de subgrupos para determinar la prevalencia según el riesgo de sesgo, criterios diagnóstico y regiones del país. En total, se incluyeron 32 estudios en este metaanálisis, con un total de 21.942 mujeres. La prevalencia combinada de diabetes gestacional en Brasil fue del 14% (IC95%: 11,0; 16,0), considerablemente más alta que las estimaciones de estudios anteriores. Con relación al riesgo de sesgo, los estudios con riesgo bajo, medio y alto mostraron una prevalencia combinada del 12%, del 14% y del 14%, respectivamente. En cuanto a la certeza de la evidencia (enfoque GRADE), la clasificación general fue baja. La mayoría de los estudios utilizó los criterios del Grupo de Estudio de la Asociación Internacional de Diabetes en el Embarazo (IADPSG) y del IADPSG adaptado, lo que muestra una prevalencia combinada del 15% y del 14%, respectivamente. Con relación a las regiones, la prevalencia combinada fue mayor en el Sudeste (14%) y menor en el Centro-Oeste (9%). Esta fue la primera revisión sistemática que proporcionó evidencias sobre la prevalencia de diabetes gestacional en el ámbito nacional, lo que demuestra una considerable heterogeneidad entre los artículos y la influencia de la región, los criterios diagnósticos y la calidad de los estudios sobre este indicador.

Abstract: This study estimates gestational diabetes mellitus prevalence in Brazil. A systematic review was conducted with articles published between 2010 and 2021 on the PubMed, Scopus, Google Scholar, SciELO, LILACS and Virtual Health Library databases, as well as gray literature. Data were extracted using a standardized instrument together with the risk of bias assessment tool proposed by Hoy et al. A meta-analysis with robust variance and random effects was developed. Heterogeneity was verified using I2 and publication bias was assessed using funnel plot and Egger’s test. Prevalence according to risk of bias, diagnostic criteria and country’s regions was determined by subgroup analyses. A total of 32 studies were included, representing 21,942 women. gestational diabetes mellitus pooled prevalence was 14% (95%CI: 11.0; 16.0), considerably higher than estimates from previous studies. Regarding risk of bias, studies with low, medium, and high risk showed a pooled prevalence of 12%, 14% and 14%, respectively. Overall GRADE certainty of evidence rating was low. Most studies used the International Association of Diabetes in Pregnancy Study Group (IADPSG) criteria or the adapted IADPSG, showing a pooled prevalence of 15% and 14%, respectively. As for region, the pooled prevalence was higher in the Southeast (14%) and lower in the Central-West (9%). This is the first systematic review to provide evidence on gestational diabetes mellitus prevalence at a national level and to demonstrate considerable heterogeneity among articles and the influence of region, diagnostic criteria and study quality on the referred indicator.

Resumo: Este artigo estimou a prevalência da diabetes gestacional no Brasil. Foi realizada uma revisão sistemática e metanálise com artigos publicados de 2010 até 2021 nas bases de dados PubMed, Scopus, Google Scholar, SciELO, LILACS e Biblioteca Virtual em Saúde, além de literatura cinzenta. Os dados foram extraídos usando um instrumento padronizado juntamente com o instrumento de avaliação de risco de viés de Hoy et al. Posteriormente, foi desenvolvida uma metanálise com variância robusta e efeitos aleatórios. A heterogeneidade foi verificada pelo uso do I2 e o viés de publicação foi avaliado pelo gráfico de funil e pelo teste de Egger. Análises de subgrupos foram realizadas para determinar a prevalência de acordo com o risco de viés, critérios diagnósticos e regiões do país. Ao todo, 32 estudos foram incluídos nesta metanálise, totalizando 21.942 mulheres. A prevalência combinada de diabetes gestacional no Brasil foi de 14% (IC95%: 11,0; 16,0), consideravelmente superior às estimativas de estudos anteriores. Em relação ao risco de viés, estudos com baixo, médio e alto risco mostraram prevalência combinada de 12%, 14% e 14%, respectivamente. Em relação à certeza da evidência (abordagem GRADE), a classificação geral foi baixa. A maioria dos estudos utilizou os critérios do Grupo de Estudo da Associação Internacional de Diabetes na Gravidez (IADPSG) e do IADPSG adaptado, mostrando uma prevalência combinada de 15% e 14%, respectivamente. Em relação às regiões, a prevalência combinada foi maior no Sudeste (14%) e menor no Centro-oeste (9%). Esta foi a primeira revisão sistemática a fornecer evidências sobre a prevalência de diabetes gestacional em nível nacional, demonstrando considerável heterogeneidade entre os artigos e a influência da região, dos critérios diagnósticos e da qualidade dos estudos sobre o referido indicador.

ABSTRACT Adjustments in the nitrogen fertilization recommendation in wheat fields are essential to promote an increase in nitrogen (N) use efficiency by the crop. The real-time estimation of the nutritional demand of plants considering the spatial variability is one of the efficient ways to perform this adjustment. This study aimed to develop a model for the indication of topdressing nitrogen fertilization as a function of nutritional N demand using NDVI. Data from field experiments conducted in four regions of the State of Rio Grande do Sul, Brazil, during the 2015, 2017, 2018, and 2019 agricultural years using cultivars with significant sowing areas in the state, were used to construct the model. The analysis of the relationship between the amounts of N accumulated in the shoot and NDVI values allowed establishing a single model for different cultivars. The proposed model is sensitive to capturing regional edaphoclimatic differences and variability in N dynamics in cultivated areas. A consistent relationship was found between NDVI values and biomass and N content, which supported the generation of the topdressing N indication model for wheat. Therefore, the proposed model has the potential to maximize N use and grain yield, in addition to optimizing the economic return of the crop. (N crop realtime real time adjustment Sul Brazil 2015 2017 2018 201 state content Therefore yield 20 2

Hematological problems are associated with Coronavirus disease 2019 (COVID-19). Respiratory impairment is the higher point studied, although without experimental studies related to the oxygen transport performed by erythrocytes. Therefore, we decided to investigate if erythrocytes from COVID-19 patients have their functionality changed. The case-control study included hospitalized patients with a positive real-time polymerase chain reaction (RT-PCR) result admitted to University Hospital. Volunteers (negative RT-PCR results) were recruited as a control group. Thus, we assessed different erythrocytes parameters, oxidative stress markers, and biophysical studies using whole blood and isolated hemoglobin. We found a decrease of 51% in oxygen uptake and reduced antioxidant enzyme activity in COVID-19 patients compared to controls. Raman spectrometry showed structural changes in the hemoglobin and lipids of the erythrocytes from COVID-19 patients; thus, these results were consolidated with an increase in Young’s modulus in erythrocytes followed by morphology changes. Besides, isolated hemoglobin from COVID-19 patients has a distinct interaction profile using a ligand model compared to the control. COVID-19 leads to structural, functional, and morphological damage to human erythrocytes. Our data showed structural and molecular changes and induction of oxidative stress in erythrocytes by COVID-19, a new perspective on the contribution of erythrocytes to a respiratory commitment in COVID-19. 201 COVID19. COVID19 COVID 19 . (COVID-19) studied Therefore COVID-1 changed casecontrol case realtime real time RTPCR RT PCR (RT-PCR Hospital negative group Thus parameters markers 51 controls thus Youngs Young s Besides functional COVID19, 19, 19. 20 COVID1 1 (COVID-19 COVID- 5 2 (COVID-1 (COVID- (COVID

ABSTRACT The piramutaba, Brachyplatystoma vaillantii is a freshwater catfish that is the most abundant fishery resource in the Amazon estuary. Piramutaba trawling is done on industrial fishing scale and is characterized by the presence of many freshwater and marine bycatch species, with and without commercial value. Here we describe the bycatch of the industrial fishery of piramutaba in the Amazon estuary and evaluate the relationship of two important environmental factors, depth and salinity, with the accidental capture of freshwater and marine fishes in the Amazon estuary in the rainy and dry seasons. We identified 21 cartilaginous fish species (19.1% freshwater and 80.9% marine) and 125 bony fish species (25.6% freshwater and 74.4% marine). The bycatch included 64 species without commercial value (43% of all bycatch species), which are always discarded. Freshwater and estuarine fishes exhibited significantly higher abundances in shallower environments, while marine fishes were similarly abundant along the entire depth gradient. On the contrary, the abundance of freshwater fishes significantly decreased, and that of estuarine and marine fishes significantly increased with increasing salinity. Regarding the conservation status of the bycatch species, one is classified as vulnerable (VU), and seven as critically endangered (CR). The information on the bycatch of piramutaba fishery in the Amazon estuary is important to subsidize regional fisheries policies and the management of protected areas. factors salinity seasons 2 19.1% 191 19 1 (19.1 809 80 9 80.9 12 25.6% 256 25 6 (25.6 744 74 4 74.4 marine. . 43% 43 (43 , species) discarded environments gradient contrary decreased VU, VU (VU) CR. CR (CR) areas 19.1 (19. 8 80. 25.6 (25. 7 74. (4 (VU (CR 19. (19 25. (25 ( (1 (2

RESUMO A piramutaba, Brachyplatystoma vaillantii é um bagre de água doce que representa o recurso pesqueiro mais abundante no estuário amazônico. O arrasto da piramutaba é feito em escala industrial, caracterizado pela presença de muitas espécies de água doce e marinha capturadas de forma incidental, com e sem valor comercial. Aqui descrevemos a captura incidental da pesca industrial de piramutaba no estuário amazônico e avaliamos a relação de dois fatores ambientais, profundidade e salinidade, com a captura incidental de espécies de água doce e marinhas nas estações chuvosa e seca. Identificamos 21 espécies de peixes cartilaginosos (19,1% de água doce e 80,9% marinhos) e 125 espécies de peixes ósseos (25,6% de água doce e 74,4% marinhos). A captura incidental incluiu 64 espécies sem valor comercial (43% de todas as espécies capturadas) que sempre são descartadas. Os peixes de água doce e estuarinos exibiram abundâncias significativamente maiores em ambientes mais rasos, enquanto os peixes marinhos foram igualmente abundantes ao longo de todo o gradiente de profundidade. Inversamente, a abundância de peixes de água doce diminuiu significativamente, e a de peixes estuarinos e marinhos aumentou significativamente em salinidades maiores. Em relação ao estado de conservação das espécies capturadas, uma é reconhecida como vulnerável (VU) e sete como criticamente ameaçadas (CR). As informações sobre a captura incidental da pesca da piramutaba no estuário amazônico são fundaentais para subsidiar políticas pesqueiras regionais e gestão de áreas protegidas. ambientais salinidade seca 2 19,1% 191 19 1 (19,1 809 80 9 80,9 12 25,6% 256 25 6 (25,6 744 74 4 74,4 marinhos. . 43% 43 (43 descartadas rasos Inversamente VU (VU CR. CR (CR) protegidas 19,1 (19, 8 80, 25,6 (25, 7 74, (4 (CR 19, (19 25, (25 ( (1 (2

Abstract Objective: To describe the behavior of total alkaline phosphatase (tALP) in patients with metastatic castration-resistant prostate cancer receiving radium-223 therapy, in a real-world scenario, and to describe overall survival (OS) among such patients. Materials and Methods: This was a retrospective study involving 97 patients treated between February 2017 and September 2020. Patients were stratified by the baseline tALP (normal/elevated). A tALP response was defined as a ≥ 30% reduction from baseline at week 12. For patients with elevated baseline tALP, we also evaluated treatment response as a ≥ 10% reduction in tALP after the first cycle of treatment. We defined OS as the time from the first treatment cycle to the date of death. Results: There was a significant reduction in the median tALP after each cycle of treatment (p < 0.05 for all). Data for tALP at week 12 were available for 71 of the 97 patients. Of those 71 patients, 26 (36.6%) responded. Elevated baseline tALP was observed in 47 patients, of whom 19 (40.4%) showed a response. Longer OS was observed in the patients with normal baseline tALP, in those with elevated baseline tALP that showed a response to treatment (≥ 10% reduction), and in those who received 5-6 cycles of therapy. Conclusion: The tALP may be used to predict which patients will benefit from treatment with a greater number of cycles of radium-223 therapy and will have longer OS. Objective (tALP castrationresistant castration resistant radium223 radium 223 radium-22 realworld real world scenario (OS Methods 9 201 2020 normal/elevated. normalelevated normal/elevated . (normal/elevated) 30 10 death Results p 005 0 05 0.0 all. all all) 1 7 2 36.6% 366 36 6 (36.6% responded 4 40.4% 404 40 (40.4% ( reduction, , reduction) 56 5 5- Conclusion radium22 22 radium-2 20 202 (normal/elevated 3 00 0. 36.6 (36.6 40.4 (40.4 radium2 radium- 36. (36. 40. (40. (36 (40 (3 (4

Resumo Objetivo: Descrever o comportamento da fosfatase alcalina total (tALP) em pacientes com carcinoma de próstata metastático resistente a castração, submetidos a terapia com rádio-223 em um cenário do mundo real, e a sobrevida global (SG) desses pacientes. Materiais e Métodos: Estudo retrospectivo envolvento 97 pacientes, no período de fevereiro/2017 a setembro/2020. Os pacientes foram estratificados de acordo com a tALP basal (normal/elevada). A resposta à tALP foi definida como uma redução em relação à linha de base de ≥ 30% na semana-12. Para pacientes com tALP basal elevada, também foi avaliada a resposta ao tratamento como uma redução de ≥ 10% de tALP após o primeiro ciclo. A SG foi definida como o tempo entre o primeiro ciclo e a data do óbito. Resultados: A redução da tALP média após cada ciclo foi significativa (p < 0,05). A tALP na semana 12 estava disponível para 71 dos 97 pacientes. Desses 71 pacientes, 26 (36,6%) responderam. Dezenove (40,4%) dos 47 pacientes com tALP elevada apresentaram resposta. Foi observada uma SG mais longa nos pacientes com tALP basal normal, nos pacientes com tALP basal elevada que apresentaram resposta ao tratamento (redução de ≥ 10%) e nos pacientes que receberam 5-6 ciclos. Conclusão: A tALP pode ser usada para prever parte dos pacientes que se beneficiarão do tratamento com um maior número de ciclos e uma SG mais longa. Objetivo (tALP castração rádio223 rádio 223 rádio-22 real (SG Métodos 9 fevereiro2017 fevereiro 2017 fevereiro/201 setembro2020 setembro 2020 setembro/2020 normal/elevada. normalelevada normal/elevada . normal (normal/elevada) 30 semana12. semana12 12. semana-12 10 óbito Resultados p 0,05. 005 0,05 0 05 0,05) 1 7 2 36,6% 366 36 6 (36,6% responderam 40,4% 404 40 4 (40,4% 56 5 5- Conclusão rádio22 22 rádio-2 fevereiro201 201 fevereiro/20 setembro202 202 setembro/202 (normal/elevada 3 semana1 semana-1 00 0,0 36,6 (36,6 40,4 (40,4 rádio2 rádio- fevereiro20 20 fevereiro/2 setembro20 setembro/20 semana- 0, 36, (36, 40, (40, fevereiro2 fevereiro/ setembro2 setembro/2 (36 (40 setembro/ (3 (4 (