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Marin-Neto, José Antonio Rassi Jr., Anis Moraes Oliveira, Gláucia M. Lemos Correia, Luís Claudio Novaes Ramos Jr., Alberto Hasslocher-Moreno, Alejandro Marcel Luquetti Ostermayer, Alejandro Sousa, Andréa Silvestre de Amato Vincenzo de Paola, Angelo Sobral de Sousa, Antonio Carlos Pinho Ribeiro, Antonio Luiz Correia Filho, Dalmo Moraes de Souza, Dilma do Socorro Cunha-Neto, Edecio J. A. Ramires, Felix Bacal, Fernando Pereira Nunes, Maria do Carmo Martinelli Filho, Martino Ibrahim Scanavacca, Maurício Magalhães Saraiva, Roberto Alves de Oliveira Júnior, Wilson M. Lorga-Filho, Adalberto de Jesus Benevides de Almeida Guimarães, Adriana Lopes Latado Braga, Adriana Sarmento de Oliveira, Adriana V. L. Sarabanda, Alvaro Yecê das Neves Pinto, Ana Assis Lopes do Carmo, André Schmidt, André Costa, Andréa Rodrigues da Ianni, Barbara Maria Markman Filho, Brivaldo Eduardo Rochitte, Carlos Thé Macedo, Carolina Mady, Charles Chevillard, Christophe Bittencourt das Virgens, Cláudio Marcelo Nery de Castro, Cleudson De Paoli de Carvalho Britto, Constança Felícia Pisani, Cristiano do Carmo Rassi, Daniela C. Sobral Filho, Dario Rodrigues Almeida, Dirceu A. Bocchi, Edimar T. Mesquita, Evandro de Souza Nogueira Sardinha Mendes, Fernanda Pereira, Francisca Tatiana Sperandio da Silva, Gilberto Marcelo de Lima Peixoto, Giselle Glotz de Lima, Gustavo H. Veloso, Henrique Turin Moreira, Henrique Bellotti Lopes, Hugo Masciarelli Francisco Pinto, Ibraim Pinto Dias, João Carlos Bemfica, João Marcos Silva-Nunes, João Paulo Soares Barreto-Filho, José Augusto Kerr Saraiva, José Francisco Lannes-Vieira, Joseli Menezes Oliveira, Joselina Luzia V. Armaganijan, Luciana Martins, Luiz Cláudio C. Sangenis, Luiz Henrique Barbosa, Marco Paulo Almeida-Santos, Marcos Antônio Simões, Marcos Vinicius Shikanai-Yasuda, Maria Aparecida Vieira Moreira, Maria da Consolação Higuchi, Maria de Lourdes Costa Monteiro, Maria Rita de Cássia Felix Mediano, Mauro Felippe Maia Lima, Mayara T. Oliveira, Maykon Moreira Dias Romano , Minna Nitz, Nadjar de Tarso Jorge Medeiros, Paulo Vieira Alves, Renato Alkmim Teixeira, Ricardo Coury Pedrosa, Roberto Aras, Roque Morais Torres, Rosália dos Santos Povoa, Rui Manoel Rassi, Sérgio Gabriel Salles Xavier, Sérgio Marinho Martins Alves , Silvia B. N. Tavares, Suelene Lima Palmeira, Swamy da Silva Junior, Telêmaco Luiz da Rocha Rodrigues, Thiago Madrini Junior, Vagner Maia da Costa , Veruska Dutra, Walderez

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Publication date: 2022-10-11

Abstract: En Pt

This guideline aimed to update the concepts and formulate the standards of conduct and scientific evidence that support them, regarding the diagnosis and treatment of the Cardiomyopathy of Chagas disease, with special emphasis on the rationality base that supported it.nbsp; Chagas disease in the 21st century maintains an epidemiological pattern of endemicity in 21 Latin American countries. Researchers and managers from endemic and non-endemic countries point to the need to adopt comprehensive public health policies to effectively control the interhuman transmission of T. cruzi infection, and to obtain an optimized level of care for already infected individuals, focusing on diagnostic and therapeutic opportunistic opportunities. nbsp; Pathogenic and pathophysiological mechanisms of the Cardiomyopathy of Chagas disease were revisited after in-depth updating and the notion that necrosis and fibrosis are stimulated by tissue parasitic persistence and adverse immune reaction, as fundamental mechanisms, assisted by autonomic and microvascular disorders, was well established. Some of them have recently formed potential targets of therapies.nbsp; The natural history of the acute and chronic phases was reviewed, with enhancement for oral transmission, indeterminate form and chronic syndromes. Recent meta-analyses of observational studies have estimated the risk of evolution from acute and indeterminate forms and mortality after chronic cardiomyopathy. Therapeutic approaches applicable to individuals with Indeterminate form of Chagas disease were specifically addressed. All methods to detect structural and/or functional alterations with various cardiac imaging techniques were also reviewed, with recommendations for use in various clinical scenarios. Mortality risk stratification based on the Rassi score, with recent studies of its application, was complemented by methods that detect myocardial fibrosis.nbsp; The current methodology for etiological diagnosis and the consequent implications of trypanonomic treatment deserved a comprehensive and in-depth approach. Also the treatment of patients at risk or with heart failure, arrhythmias and thromboembolic events, based on pharmacological and complementary resources, received special attention. Additional chapters supported the conducts applicable to several special contexts, including t. cruzi/HIV co-infection, risk during surgeries, in pregnant women, in the reactivation of infection after heart transplantation, and others.nbsp; nbsp;nbsp; Finally, two chapters of great social significance, addressing the structuring of specialized services to care for individuals with the Cardiomyopathy of Chagas disease, and reviewing the concepts of severe heart disease and its medical-labor implications completed this guideline.

Esta diretriz teve como objetivo principal atualizar os conceitos e formular as normas de conduta e evidências científicas que as suportam, quanto ao diagnóstico e tratamento da CDC, com especial ênfase na base de racionalidade que a embasou. A DC no século XXI mantém padrão epidemiológico de endemicidade em 21 países da América Latina. Investigadores e gestores de países endêmicos e não endêmicos indigitam a necessidade de se adotarem políticas abrangentes, de saúde pública, para controle eficaz da transmissão inter-humanos da infecção pelo T. cruzi, e obter-se nível otimizado de atendimento aos indivíduos já infectados, com foco em oportunização diagnóstica e terapêutica. Mecanismos patogênicos e fisiopatológicos da CDC foram revisitados após atualização aprofundada e ficou bem consolidada a noção de que necrose e fibrose sejam estimuladas pela persistência parasitária tissular e reação imune adversa, como mecanismos fundamentais, coadjuvados por distúrbios autonômicos e microvasculares. Alguns deles recentemente constituíram alvos potenciais de terapêuticas. A história natural das fases aguda e crônica foi revista, com realce para a transmissão oral, a forma indeterminada e as síndromes crônicas. Metanálises recentes de estudos observacionais estimaram o risco de evolução a partir das formas aguda e indeterminada e de mortalidade após instalação da cardiomiopatia crônica. Condutas terapêuticas aplicáveis aos indivíduos com a FIDC foram abordadas especificamente. Todos os métodos para detectar alterações estruturais e/ou funcionais com variadas técnicas de imageamento cardíaco também foram revisados, com recomendações de uso nos vários cenários clínicos. Estratificação de risco de mortalidade fundamentada no escore de Rassi, com estudos recentes de sua aplicação, foi complementada por métodos que detectam fibrose miocárdica. A metodologia atual para diagnóstico etiológico e as consequentes implicações do tratamento tripanossomicida mereceram enfoque abrangente e aprofundado. Também o tratamento de pacientes em risco ou com insuficiência cardíaca, arritmias e eventos tromboembólicos, baseado em recursos farmacológicos e complementares, recebeu especial atenção. Capítulos suplementares subsidiaram as condutas aplicáveis a diversos contextos especiais, entre eles o da co-infecção por T. cruzi/HIV, risco durante cirurgias, em grávidas, na reativação da infecção após transplante cardíacos, e outros.nbsp;nbsp;nbsp; Por fim, dois capítulos de grande significado social, abordando a estruturação de serviços especializados para atendimento aos indivíduos com a CDC, e revisando os conceitos de cardiopatia grave e suas implicações médico-trabalhistas completaram esta diretriz.nbsp;

https://doi.org/10.1590/SciELOPreprints.4820

Avaliação do grau da implantação do Programa Saúde na Escola em município do nordeste brasileiro
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Rodrigues de Medeiros, Eliabe

; Yoshimi Tanaka, Oswaldo

; Lima de Souza, Nilba

; Brandão Batista dos Santos, Paula Fernanda

; Galvão Pinto, Erika Simone

Revista de Salud Pública

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feb 2021, Volume 23 N. 1 Pages 1 -

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

RESUMO Objetivo Avaliar o grau da implantação do Programa Saúde na Escola em um município do nordeste brasileiro. Métodos Trata-se de estudo de avaliação da implantação, onde foram definidos os critérios e os parâmetros para comparação baseado nos componentes de qualidade donabediano. A coleta de dados aconteceu de maio à julho de 2017, em um município do nordeste do Brasil. Participaram 105 profissionais da Estratégia Saúde da Família por meio de instrumento construído a partir das normatizações do programa. Os dados foram organizados em planilhas do IBM SPSS Statistics, versão 22.0 e analisados a partir da estatística descritiva. Resultados A intervenção apresenta implantação incipiente (33,1%), classificação identificada nas dimensões estrutura (29,3%) e processo (34,8%). Conclusão O Programa Saúde na Escola possui implantação incipiente no município que remete à necessidade de aprimoramento das suas ações e recursos utilizados.

ABSTRACT Objective To evaluate the degree of implantation of the School Health Program in a municipality in northeastern Brazil. Methods This is an implantation evaluation study, where criteria and parameters for comparison were defined based on the Donabedian quality components. Data collection took place from May to July 2017, in a municipality in northeastern Brazil. 105 professionals from the Family Health Strategy participated by means of an instrument built from the program's norms. The data were organized in spreadsheets of IBM SPSS Statistics, version 22.0 and analyzed using descriptive statistics. Results The intervention has incipient implantation (33.1%), classification identified in the structure (29.3%) and process (34.8%) dimensions. Conclusion The School Health Program has an incipient implantation in the municipality that refers to the need to improve its actions and resources used.

RESUMEN Objetivo Evaluar el grado de implantación del Programa Salud en la Escuela en un municipio del noreste de Brasil. Métodos Estudio de evaluación de implantación, en el cual los criterios y parámetros para la comparación se definieron con base en los componentes de calidad de Donabedian. La recopilación de datos tuvo lugar de mayo a julio de 2017 en un municipio del noreste de Brasil. Participaron 105 profesionales de la Estrategia de Salud de la Familia mediante un instrumento construido a partir de las normas del programa. Los datos se organizaron en hojas de cálculo de IBM SPSS Statistics, versión 22.0 y se analizaron mediante estadísticas descriptivas. Resultados La intervención presenta implantación incipiente (33.1%), clasificación identificada en la estructura (29.3%) y dimensiones del proceso (34.8%). Conclusión El Programa Salud en la Escuela tiene una implantación incipiente en el municipio que se refiere a la necesidad de mejorar sus acciones y recursos utilizados.

https://doi.org/10.15446/rsap.v23n1.86258

Factors associated to quality of life in patients with leprosy
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Pinto, Graziele Ferreira

; Nicácio, Raquel Aparecida Rodrigues

; Oliveira, Fernanda Rocha Anjos de

; Oliveira, Isabella Alcantara de

; Alves, Rauni Jandé Roama

; Santos, Débora Aparecida da Silva

; Goulart, Letícia Silveira

einstein (São Paulo)

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2021, Volume 19 elocation eAO5936

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Objetivo Avaliar a qualidade de vida e seus fatores associados em pacientes com hanseníase. Métodos Estudo transversal com 63 indivíduos com diagnóstico de hanseníase acompanhados em um serviço de atendimento especializado da região sudeste de Mato Grosso. Para avaliação da qualidade de vida, aplicou-se o questionário World Health Organization Quality of Life Bref . Utilizou-se regressão linear simples e múltipla para avaliar a associação entre varáveis sociodemográficas e os domínios de qualidade de vida. Resultados A maior média de qualidade de vida foi observada no domínio psicológico (16,28±2,30) e a menor, no domínio ambiente (13,86±2,21). As mulheres, indivíduos sem companheiro e aqueles que possuíam casa própria apresentaram menores médias de qualidade de vida no domínio psicológico. Os indivíduos que não receberam visita de Agentes Comunitários de Saúde apresentaram menores médias de qualidade de vida no domínio ambiente. Após análise multivariada, verificou-se que melhor qualidade de vida esteve associada à autodeclaração de cor branca no domínio ambiente, e pior qualidade de vida foi associada à menor escolaridade no domínio físico. Conclusão Este estudo evidenciou a influência dos fatores socioedemográficos sobre a qualidade de vida de pacientes com hanseníase, indicando a necessidade de realização de uma assistência em saúde de maneira integral, compreendendo os determinantes sociais da saúde.

ABSTRACT Objective To evaluate quality of life and associated factors in patients with leprosy. Methods A cross-sectional study with 63 people diagnosed as leprosy, seen at a reference service for the disease in the southeastern region of Mato Grosso, Brazil. The questionnaire World Health Organization Quality of Life Bref was used to evaluate quality of life. Simple and multiple linear regressions evaluated the association between sociodemographic variables and quality of life domains. Results The highest mean of quality of life was observed in the psychological domain (16.28±2.30), and the lowest in the environmental domain (13.86±2.21). Females, individuals with no partners, and people who owned their own house had the lowest quality of life means within the psychological domain. People who did not receive visits by Community Health Workers had the lowest means in quality of life within the environmental domain. Multivariate analysis revealed that the best quality of life was associated to self-reported white skin color within the environmental domain, and the worst quality of life was associated to less schooling within the physical domain. Conclusion This study showed the influence of sociodemographic factors on the quality of life of patients with leprosy, and indicated the need for comprehensive health care, considering the social determinants of health.

https://doi.org/10.31744/einstein_journal/2021ao5936 90 downloads

biochemical attributes and establishment of tree seedlings in soil after urochloa decumbens cultivation in soil with deposition of iron mining residues
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Ribeiro Junior, Alexandre Carvalho

; Silva, Aline Oliveira

; Batista, Éder Rodrigues

; Naves, Filipe Sales

; Pinto, Flávio Araújo

; Santos, Jessé Valentim dos

; Barbosa, Marisângela Viana

; Alvarenga, Ingrid Fernanda Santana

; Carneiro, Marco Aurélio Carbone

CERNE

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2021, Volume 27 elocation e-102623

Abstract: En | Text: En | PDF: En

abstract background: the recovery of areas impacted by mining activities is a major challenge and requires knowledge of how the biological and biochemical processes of the soil as well as the establishment of plant species are affected by mining residue. in this work, the influence of deposition of iron mining mud and tailings on soil biochemical attributes and the initial development of tree seedlings was studied in a simulated event in the greenhouse. pots (n = 27) with natural soil (2.0 kg) received deposition (280 ml) of iron mining mud or tailings and by three-month was cultivated with urochloa decumbens. at the end of this period, part of the pots was sampled and the soil biochemical activities were evaluated. then tree seedlings (schinus terebinthifolius and eremanthus incanus) were planted and cultivated for a year, when then shoot (sdw) and roots (rdw) dry weight were evaluated. results: deposition of iron mining mud and tailings did not affect microbial biomass carbon or basal soil respiration, however both conditions reduced (p < 0.05) β-glucosidase activities by up to 30%, and the easy extractable glomalin by about 19%. in addition, the mud deposition reduced (p < 0.05) the sdw and rdw of s. terebinthifolius by about 21% and 24%, respectively. nevertheless, uruchloa decumbens and eremanthus incanus had no variation in dry weight production between treatments, so they have good ability to grow settle in soil affected by mining residue. conclusion: this study shows that the sequential planting of u. decumbens and e. incanus can be an alternative for use in environments with deposition of iron mining tailings.

https://doi.org/10.1590/01047760202127012623 103 downloads

Presence of trypanosomatids, with emphasis on Leishmania, in Rodentia and Didelphimorphia mammals of a rural settlement in the central Amazon region
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Achilles, Genevere Reis

; Kautzmann, Rafael Pinto

; Chagas, Haile Dean Figueiredo

; Pereira-Silva, Jordam William

; Almeida, Jéssica Feijó

; Fonseca, Fernanda Rodrigues

; da Silva, Maria Nazareth Ferreira

; Pessoa, Felipe Arley Costa

; Nava, Alessandra Ferreira Dales

; Ríos-Velásquez, Claudia María

Memórias do Instituto Oswaldo Cruz

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2021, Volume 116 elocation e200427

Abstract: En | Text: En | PDF: En

BACKGROUND Trypanosomatids are widespread and cause diseases - such as trypanosomiasis, sleeping sickness, Chagas disease, and cutaneous and visceral leishmaniasis - in animals and humans. These diseases occur in both rural and urban regions due to unplanned growth and deforestation. Thus, wild and synanthropic reservoir hosts living in residential areas are risk factors. OBJECTIVE We aimed to evaluate the diversity of small mammals (rodents and marsupials), and the occurrence of trypanosomatids, especially Leishmania, in the rural settlement of Presidente Figueiredo, Amazonas. METHODS Animals were collected using Sherman, Tomahawk, and Pitfall traps along 16 trails in four landscapes: continuous forest, forest with planting, planting, and peridomiciliar. Leishmania sp. was detected in liver samples by polymerase chain reaction targeting kDNA. FINDINGS Diversity was higher in forests with planting and lower around residences. In total, 135 mammals (81 rodents and 54 marsupials covering 14 genera) were captured. Rodents presented infection rates (IR) of 74% and marsupials of 48%. Rodents in domicile landscapes presented a higher IR (92.9%), while marsupials showed a higher IR in forests (53.3%). MAIN CONCLUSIONS The results suggest high prevalence of trypanosomatids across 12 mammalian genera possibly involved as reservoir hosts in the enzootic transmission of leishmaniasis in the Amazon’s rural, peridomiciliar landscape.

https://doi.org/10.1590/0074-02760200427 117 downloads

Identification of clusters of asthma control: A preliminary analysis of the Inspirers studies
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Jácome, Cristina

; Amaral, Rita

; Almeida, Rute

; Pereira, Ana Margarida

; Couto, Mariana

; Araújo, Luís

; Alves-Correia, Magna

; Pereira, Mariana

; Ferreira-Magalhães, Manuel

; Loureiro, Cláudia Chaves

; Catarata, Maria Joana

; Santos, Lília Maia

; Cabral, Sara

; Pereira, João

; Ramos, Bárbara

; Lopes, Cristina

; Mendes, Ana

; Lopes, Anabela

; Rodrigues, José Carlos Cidrais

; Oliveira, Georgeta

; Aguiar, Ana Paula

; Afonso, Ivete

; Carvalho, Joana

; Arrobas, Ana Maria

; Costa, José

; Valério, Margarida

; Pereira, Marta

; Almeida, Teresa

; Dias, Joana

; Bom, Ana Todo

; Azevedo, João

; Ribeiro, Carmelita

; Alves, Marta

; Pinto, Paula Leiria

; Neuparth, Nuno

; Neves, Ana Castro

; Palhinha, Ana

; Marques, João Gaspar

; Martins, Pedro

; Trincão, David Pina

; Todo-Bom, Filipa

; Santos, Maria Alvarenga

; Branco, Joana

; Costa, Alberto

; Neto, Armandina Silva

; Santalha, Marta

; Lozoya, Carlos

; Santos, Natacha

; Silva, Diana

; Vasconcelos, Maria João

; Barata, Luís Taborda

; Teixeira, Maria Fernanda

; Pinto, Diana

; Alves, Rodrigo Rodrigues

; Moreira, Ana Sofia

; Pinto, Cláudia Sofia

; Silva, Pedro Morais

; Alves, Carlos

; Câmara, Raquel

; Coelho, Didina

; Bordalo, Diana

; Carvalho, Fernanda

; Fernandes, Ricardo

; Ferreira, Rosário

; Oliveira, José Ferraz de

; Menezes, Fernando

; Gomes, Ricardo

; Calix, Maria José

; Marques, Ana

; Cardoso, João

; Emiliano, Madalena

; Gerardo, Rita

; Nunes, Carlos

; Ferreira, José Alberto

; Lopes, Inês

; Alves, Adelaide

; Fonseca, João Almeida

Revista Portuguesa de Imunoalergologia

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dec 2020, Volume 28 N. 4 Pages 231 - 240

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Objetivos: Identificar clusters de controlo da asma baseados no Teste de Controlo da Asma e Rinite Alérgica (CARAT) e comparar as características dos doentes nos diferentes clusters. Métodos: Adultos e adolescentes (≥13 anos) com asma persistente foram recrutados em 29 centros no contexto de 2 estudos observacionais do projeto INSPIRERS. Foram recolhidos dados relativos a características demográficas e clínicas, adesão ao inalador, crenças sobre a medicação, sintomas de ansiedade e depressão, qualidade de vida e controlo da asma (CARAT, >24 bom controlo). Foi efetuada uma análise hierárquica de clusters usando a pontuação total do CARAT (CARAT-T).Resultados: Foram analisados 410 doentes (68% adultos), com uma idade mediana (percentil 25-percentil 75) de 28 (16-46) anos. Foram identificados três clusters [média CARAT-T(min-max)]: cluster 1 [27(24-30)], cluster 2 [19(14-23)] e cluster 3 [10(2-13)]. Os doentes no cluster 1 (34%) apresentavam melhor controlo da asma, melhor qualidade de vida, maior adesão aos inaladores e usavam um único inalador. Os doentes nos clusters 2 (50%) e 3 (16%) tinham a asma não controlada, menor adesão aos inaladores, mais sintomas de ansiedade e depressão e mais de metade reportavam pelo menos uma exacerbação no último ano. Adicionalmente, os doentes no cluster 3 eram predominantemente mulheres, tinham mais consultas médicas não agendadas, apresentavam mais sintomas de ansiedade, percebiam uma maior necessidade dos inaladores, mas também uma maior preocupação associada ao seu uso. Não se verificaram diferenças na idade, índice de massa corporal, função pulmonar, hábitos tabágicos, hospitalizações ou tempo de seguimento pelo médico especialista. Conclusões: Um método não supervisionado baseado no CARAT-T, identificou 3 clusters de doentes com diferentes características clínicas. O cluster com melhor controlo apresenta um ponto de corte semelhante ao estabelecido no estudo de validação do CARAT. Este estudo sugere ainda a existência de um ponto de corte adicional para distinguir doença mais grave. Mais investigação é necessária para validar os clusters identificados

Aims: To identify distinct asthma control clusters based on Control of Allergic Rhinitis and Asthma Test (CARAT) and to compare patients’ characteristics among these clusters. Methods: Adults and adolescents (≥13 years) with persistent asthma were recruited at 29 Portuguese hospital outpatient clinics, in the context of two observational studies of the INSPIRERS project. Demographic and clinical characteristics, adherence to inhaled medication, beliefs about inhaled medication, anxiety and depression, quality of life, and asthma control (CARAT, >24 good control) were collected. Hierarchical cluster analysis was performed using CARAT total score (CARAT-T). Results: 410 patients (68% adults), with a median (percentile 25-percentile 75) age of 28 (16-46) years, were analysed. Three clusters were identified [mean CARAT-T (min-max)]: cluster 1 [27(24-30)], cluster 2 [19(14-23)] and cluster 3 [10(2-13)]. Patients in cluster 1 (34%) were characterised by better asthma control, better quality of life, higher inhaler adherence and use of a single inhaler. Patients in clusters 2 (50%) and 3 (16%) had uncontrolled asthma, lower inhaler adherence, more symptoms of anxiety and depression and more than half had at least one exacerbation in the previous year. Furthermore, patients in cluster 3 were predominantly female, had more unscheduled medical visits and more anxiety symptoms, perceived a higher necessity of their prescribed inhalers but also higher levels of concern about taking these inhalers. There were no differences in age, body mass index, lung function, smoking status, hospital admissions or specialist physician follow-up time among the three clusters. Conclusion: An unsupervised method based on CARAT-T, identified 3 clusters of patients with distinct, clinically meaningful characteristics. The cluster with better asthma control had a cut-off similar to the established in the validation study of CARAT and an additional cut-off seems to distinguish more severe disease. Further research is necessary to validate the asthma control clusters identified.

https://doi.org/10.32932/rpia.2020.12.046 633 downloads

COMPARATIVE STUDY OF TiO2 AND ZnO APPLICATION IN HYBRID SOLAR CELLS USING COPOLYMER P3OT/P3MT
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Larsson, Letícia Fernanda Gonçalves

; Tractz, Gideã Taques

; Maia, Guilherme Arielo Rodrigues

; Alves, Guilherme José Turcatel

; Rodrigues, Paulo Rogério Pinto

; Cunha, Maico Taras da

; Banczek, Everson do Prado

Química Nova

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mar 2019, Volume 42 N. 3 Pages 283 - 288

Abstract: En | Text: En | PDF: En

Hybrid inorganic-organic solar cells are an attractive alternative energy source because of their low-cost production and ability to make use of a large amount of solar radiation available. This work aims to evaluate different solar cells composed of TiO2 and ZnO with P3OT/P3MT copolymer. Layers of semiconductor oxides were deposited on transparent fluorine-doped tin oxide (FTO) by spin coating and adsorption in the polymer solution. X-ray diffraction (XRD), scanning electron microscopy (SEM), were used to characterize the fabricated semiconductors and curves of current density vs. potential (j-V), photochronoamperometry (j-t) and electrochemical impedance spectroscopy (EIS) were used to determine their electrical characteristics. The XRD analyses confirmed the crystalline nature of the oxide materials. SEM micrographs showed the spherical morphology of ZnO and the poorly defined agglomerate morphology of TiO2. The electrochemical measurements proved that the best cell was produced with P3OT/P3MT copolymer and TiO2, owing to its lower charge transfer resistance, with the following photovoltaic parameters: Voc = 0.615 V ± 0.004, jsc = 1.545 mA cm-2 ± 0.240, FF = 0.637 ± 0.003, and η = 0.617% ± 0.117.

https://doi.org/10.21577/0100-4042.20170344 512 downloads

Inflammatory markers in the saliva of cerebral palsy individuals with gingivitis after periodontal treatment
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YOSHIDA, Rosemeire Arai

; GORJÃO, Renata

; MAYER, Marcia Pinto Alves

; CORAZZA, Paola Fernanda Leal

; GUARE, Renata Oliveira

; FERREIRA, Ana Cristina Fernandes Maria

; SANTOS, Maria Teresa Botti Rodrigues

Brazilian Oral Research

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2019, Volume 33 elocation e033

Abstract: En | Text: En | PDF: En

Abstract The aim of this study was to evaluate the effect of periodontal treatment on the salivary cytokine levels and clinical parameters of individuals with cerebral palsy (CP) with gingivitis. A non-randomized, clinical trial was conducted in individuals diagnosed with spastic CP. Thirty-eight individuals were enrolled in the study and were categorized according to gingival index scores between 0-1 or 2-3, assigned to groups G2 or G1, respectively. Periodontal treatment comprised oral hygiene instructions, conventional mechanical treatment and 0.12% chlorhexidine applied as an adjunct. Clinical parameters and saliva samples were collected at baseline and at the 15-day follow-up visit. Bleeding on probing and periodontal screening and recording were determined. Non-stimulated saliva samples were obtained, and the salivary flow rate, the osmolality and the levels of cytokines IL-1β, IL-6, IL-8, IL-10, TNF-α and IL-12p70 were evaluated by a cytometric bead array. The Wilcoxon test, the Mann-Whitney test, Spearman correlation analysis, Poisson regression analysis and an adjusted analysis were performed (α = 0.05). The groups differed significantly in periodontal clinical parameters at baseline and at follow-up. Salivary flow rate and osmolality were similar in both groups at both timepoints. However, TNF-α and IL-1β levels were higher in G1 than in G2 at baseline. Mechanical treatment resulted in improved clinical parameters for both groups. Furthermore, mechanical treatment resulted in a significant reduction in salivary IL-1β and IL-8 levels for both groups after treatment. Periodontal treatment performed in individuals with CP and gingivitis reduces the levels of TNF-α, IL-1β, IL-6 and IL-8.

https://doi.org/10.1590/1807-3107bor-2019.vol33.0033 2093 downloads

10.

Application of Zinc Oxide in Hybrid Solar Cells Using a P3HT and P3OT Polymer Junction as Charge Carrier
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Larsson, Letícia Fernanda Gonçalves

; Maia, Guilherme Arielo Rodrigues

; Tractz, Gideã Taques

; Valério, Tatiana Lima

; Oliszeski, Danielle Cristina Silva

; Helleis, Rodrigo

; Cunha, Maico Taras da

; Rodrigues, Paulo Rogério Pinto

; Banczek, Everson do Prado

Materials Research

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2019, Volume 22 elocation e20180820

Abstract: En | Text: En | PDF: En

Hybrid solar cells show an increasing number in researches due to its low cost and easy of production. They are composed by and organic material and a semiconductor oxide. The aim of this paper was to synthesis and characterize zinc oxide by coprecipitation and apply it in a hybrid solar cell that uses a P3HT/P3OT copolymer as charge carrier. The cell was assembled in "sandwich" form using FTO/ZnO/P3HT-P3OT as work electrode, (Pt/FTO) as conter electrode and I/I-3 redox couple as electrolyte. Through the X-ray diffractogram the formation of a single ZnO wutzite hexagonal phase was observed. The morphology obtained for the oxide was spherical. The results of photochronoamperometry showed current density values of jP3HT/P3OT =0.55 mA.cm-2 for the cell in the presence of the copolymer and the curve jxV showed an efficiency of 0.16% for the studied cell, demonstrating that the polymer was a satisfactory sensitizer.

https://doi.org/10.1590/1980-5373-mr-2018-0820 1081 downloads

11.

Study of the Nb2O5 Insertion in ZnO to Dye-sensitized Solar Cells
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Valerio, Tatiana Lima

; Maia, Guilherme Arielo Rodrigues

; Gonçalves, Letícia Fernanda

; Viomar, Aline

; Banczek, Everson do Prado

; Rodrigues, Paulo Rogério Pinto

Materials Research

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2019, Volume 22 elocation e20180864

Abstract: En | Text: En | PDF: En

Dye-sensitized solar cells (DSSC) have received much attention as an alternative to silicon-based solar cells, due to various advantages. Zinc oxide (ZnO) is an n-type semiconductor employed as photoanode on DSSC. The decrease of charge recombination is an efficient strategy capable of improving the photovoltaic performance of the device. In this perspective, Nb2O5 was added on ZnO solar cells. The oxides were characterized by the X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FTIR) and X-ray fluorescence (XRF). The photovoltaic parameters were obtained through J-V plots and photocronoamperometry. The results showed that the niobium oxide obtained presented orthorhombic crystal structure and DSSC with the addition of niobium oxide showed better efficiency, of 1.42% when compared the device with only ZnO.

https://doi.org/10.1590/1980-5373-mr-2018-0864 1046 downloads

12.

Estado funcional e nutricional em pacientes idosos admitidos num serviço de cirurgia geral
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Preto, Leonel São Romão

; Lopes, Isabel Fernanda

; Mendes, Maria Eugénia Rodrigues

; Novo, André Filipe Morais Pinto

; Barreira, Ilda Maria Morais

Revista de Enfermagem Referência

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jun 2018, Volume serIV N. 17 Pages 43 - 52

Abstract: Es Pt En | Text: Es Pt En | PDF: Es | PDF: Pt | PDF: En

Marco contextual: El compromiso funcional y la desnutrición asociada a la enfermedad aumentan el riesgo de resultados adversos en la salud. Objetivo: Correlacionar la capacidad funcional con el estado nutricional en pacientes de más de 65 años admitidos en un servicio de cirugía. Metodología: Estudio descriptivo y correlacional con enfoque cuantitativo en el que se evaluó, por muestreo de conveniencia y protocolo de investigación aprobado por la Comisión de Ética, 89 ancianos (78,0 ± 6,9 años) hospitalizados en un servicio de cirugía. La funcionalidad se evaluó mediante el Índice de Barthel (IB) y la Escala de Lawton y Brody (ELB), y el estado nutricional por la Mini Nutritional Assessment Short-Form (MNA-SF). Resultados: La prevalencia de desnutrición fue del 16,9%. Las puntuaciones obtenidas en el IB y la ELB se correlacionaron positivamente con los valores de la MNA-SF (R = 0,400; p < 0,01 vs R = 0,267; p < 0,05). Los pacientes más mayores presentaron menores puntuaciones en el IB, la ELB y la MNA-SF (p < 0,01). Cuanto mayor es la fuerza de agarre de la mano dominante, mejor es el estado funcional y nutricional (p < 0,01). Conclusión: Debido a la relación que se encontró entre funcionalidad y estado nutricional, se recomienda clasificar estas condiciones en el paciente quirúrgico.

Enquadramento: O comprometimento funcional e a desnutrição associada à doença aumentam o risco de resultados adversos em saúde. Objetivo: Correlacionar a capacidade funcional com o estado nutricional em pacientes com mais de 65 anos admitidos num serviço de cirurgia. Metodologia: Estudo descritivo e correlacional com abordagem quantitativa, que avaliou, por amostragem de conveniência e protocolo de investigação aprovado por Comissão de Ética, 89 idosos (78,0 ± 6,9 anos) hospitalizados num serviço de cirurgia. A funcionalidade foi avaliada pelo Índice de Barthel (IB) e Escala Lawton e Brody (ELB) e o estado nutricional pelo Mini Nutritional Assessment Short-Form (MNA-SF). Resultados: A prevalência de desnutrição foi de 16,9%. As pontuações obtidas no IB e ELB correlacionaram-se de forma positiva com os valores do MNA-SF (R = 0,400; p < 0,01 vs R = 0,267; p < 0,05). Pacientes mais idosos apresentavam menores pontuações no IB, ELB e MNA-SF (p < 0,01). Quanto maior a força de preensão da mão dominante, melhor o estado funcional e nutricional (p < 0,01). Conclusão: A relação encontrada entre funcionalidade e estado nutricional recomenda a triagem destas condições no paciente cirúrgico.

Background: Disease-related functional impairment and malnutrition increase the risk of adverse health outcomes. Objective: To establish a correlation between functional capacity and nutritional status in patients aged over 65 years who were admitted to a general surgery ward. Methodology: Descriptive and correlational study with a quantitative approach. The sample was composed of 89 older adults (78,0 ± 6,9 years) admitted to a general surgery ward. Participants were selected using the convenience sampling technique. The research protocol was approved by the Ethics Committee. Patients' functional capacity was assessed using the Barthel Index (BI) and the Lawton and Brody Scale (LBS), and the nutritional status was assessed using the Mini Nutritional Assessment Short-Form (MNA-SF). Results: The prevalence of malnutrition was 16.9%. Both BI and LBS scores showed a positive correlation with the MNA-SF scores (R = 0.400, p < 0.01 vs R = 0.267, p < 0.05). The oldest inpatients had lower BI, LBS, and MNA-SF scores (p < 0.01). Inpatients with a better functional and nutritional status had greater grip strength in the dominant hand (p < 0.01). Conclusion: Based on the association found between functional capacity and nutritional status, it is recommended to screen surgical patients for these conditions.

https://doi.org/10.12707/RIV17093 581 downloads

13.

"BAIXADEIROS" HORSES: PREVALENCE OF ANTI-Trypanosoma spp. AND ANTI-Leishmania spp. ANTIBODIES
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Ferreira, Fernanda Pinto

; Caldart, Eloiza Teles

; Brito, Danilo Rodrigues Barros

; Chaves, Daniel Praseres

; Garcia, João Luis

; Navarro, Italmar Teodorico

Ciência Animal Brasileira

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2018, Volume 19 elocation e-51522

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Um total de 138 amostras de sangue de equinos foram coletadas nos anos de 2012 a 2013 para posterior obtenção de soro. Para detecção de anticorpos anti-Leishmania spp. e anti-Trypanossoma spp. realizou-se a reação de imunofluorescência indireta e o ensaio imunoenzimático. Consideraram-se positivas, na RIFI, amostras com títulos iguais ou superiores a 40; o ponto de corte do ELISA foi calculado com três desvios padrão. Quando testadas para Trypanosoma spp., 50,37% (68/135) das amostras foram reagentes ao ELISA, 18,84% (8/136) à RIFI e 2,89% (4/138) para os dois testes. Observou-se associação estatística significativa quanto ao município (p= 0.013) e período de coleta (p=0.042) no ELISA. Quando testadas para Leishmania spp., 25,4% (35/138) das amostras foram positivas ao ELISA, 13,00% (18/138) à RIFI e 4,34% (6/138) nos dois testes, não havendo variáveis associadas estatisticamente à soropositividade. Foi observada associação estatística (p=0,0034) entre presença de anticorpos anti-Trypanosoma spp. e anti-Leishmania spp., quando utilizada a técnica de ELISA. Os resultados obtidos sugerem que esta raça de cavalo está em contato com os agentes das leishmanioses e tripanossomíases, demonstrando a necessidade de uma investigação mais precisa sobre o real papel de cavalos nessas enfermidades, a fim de auxiliar nas medidas de controle da doença.

Abstract A total of 138 horse blood samples were collected from 2012 to 2013 for the subsequent separation of serum collection. For detection of anti-Leishmania spp. and anti-Trypanosoma spp. antibodies, indirect immunofluorescence reactions and immunoenzymatic assays were performed. Samples with titers ≥40 were considered positive in the indirect immunofluorescence (IFAT), and the cut off for the enzyme immunoassay (ELISA) was calculated with three standard deviations. When tested for Trypanosoma spp., 50.37% (68/135) of the samples were ELISA reagents, 18.84% (8/136) were positive for IFAT and 2.89% (4/138) for both tests. A significant statistical association was observed for the municipality (p = 0.013) and collection period (p = 0.042) in the ELISA. When tested for Leishmania spp., 25.4% (35/138) of the samples were ELISA reagents, 13.00% (18/138) were positive for the IFAT and 4.34% (6/138) were positive for two tests, there were no variables associated with seropositivity. A statistical association (p = 0.0034) was observed between the presence of anti-Trypanosoma spp. and anti-Leishmania spp. antibodies when the ELISA was used. The results suggest that this horse breed is in contact with leishmaniasis and trypanosomiasis, which demonstrates the need for a more accurate investigation into the real role of horses in these diseases to assist in disease control measures.

https://doi.org/10.1590/1809-6891v19e-51522 640 downloads

14.

Acute myeloid leukemia with e1a2 BCR-ABL1 fusion gene: two cases with peculiar molecular and clinical presentations
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Silva, Fernanda Borges da

; Machado-Neto, João Agostinho

; Koury, Luisa Corrêa de Araujo

; Bertini, Virginia Helena Leira Lipoli

; Ratis, Cristina Alonso

; Chauffaille, Maria de Lourdes Lopes Ferrari

; Velloso, Elvira Deolinda Rodrigues Pereira

; Simões, Belinda Pinto

; Rego, Eduardo Magalhães

; Traina, Fabiola

Revista Brasileira de Hematologia e Hemoterapia

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dec 2017, Volume 39 N. 4 Pages 379 - 384

Abstract: En | Text: En | PDF: En

https://doi.org/10.1016/j.bjhh.2017.07.001 1060 downloads

15.

Desempenho do reanimador durante seis minutos de compressões torácicas realizadas em ambiente simulado
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Preto, Leonel São Romão

; Novo, André Filipe Morais Pinto

; Mendes, Maria Eugénia Rodrigues

; Azevedo, Ana Fernanda Ribeiro

Revista de Enfermagem Referência

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may 2016, Volume serIV N. 9 Pages 47 - 56

Abstract: Es Pt En | Text: Es Pt En | PDF: Es | PDF: Pt | PDF: En

Marco contextual: Las compresiones torácicas realizadas con calidad y según las directrices internacionales influyen en los resultados y la supervivencia del paro cardíaco. Objetivos: Analizar la influencia de la fatiga y la aptitud física en el desempeño del reanimador durante 6 minutos de compresiones torácicas continuas. Metodología: Estudio descriptivo y correlacional que incluyó a 38 profesionales experimentados en reanimación. La fatiga fue evaluada por el nivel del lactato capilar, la aptitud física a través de pruebas de fuerza y composición corporal y el desempeño del reanimador por el porcentaje de compresiones correctas por minuto realizadas en un maniquí. Resultados: El porcentaje de compresiones correctas disminuyó minuto a minuto (p< 0,05). El lactato aumentó de un valor basal de 1,7 ± 0,7mmol/L a 5,4 ± 1,5mmol/L, permaneciendo elevado después de 20 minutos de reposo. La fuerza manual, así como la fuerza y la masa muscular del tronco y brazos se correlacionaron positivamente con el porcentaje de compresiones correctas realizadas. Conclusión: El índice de masa corporal y los componentes de aptitud física, fuerza y masa muscular fueron las variables que mejor explicaron la calidad del masaje a lo largo del tiempo.

Enquadramento: As compressões torácicas realizadas com qualidade e segundo as diretrizes internacionais influenciam os resultados e a sobrevida na paragem cardíaca. Objetivos: Analisar a influência da fadiga e da aptidão física no desempenho do reanimador durante 6 minutos de compressões torácicas contínuas. Metodologia: Estudo descritivo-correlacional, envolvendo 38 profissionais experientes em reanimação. A fadiga foi avaliada através do nível de lactato capilar, a aptidão física através de testes de força e composição corporal e o desempenho do reanimador pela percentagem correta de compressões por minuto, realizadas em manequim. Resultados: A percentagem de compressões corretas decresceu minuto a minuto (p<0,05). O lactato subiu de um valor basal de 1,7±0,7mmol/L para 5,4±1,5mmol/L, mantendo-se elevado após 20 minutos de repouso. A força manual e a força e massa muscular do tronco e membros superiores correlacionaram-se positivamente com a percentagem de compressões corretas efetuadas. Conclusão: O índice de massa corporal e as componentes de aptidão física, força e massa muscular foram as variáveis que melhor explicaram a qualidade da massagem ao longo do tempo.

Background: The performance of quality chest compressions according to the international guidelines affects the outcomes and survival in cardiac arrest. Objectives: To analyze the influence of fatigue and physical fitness on the rescuer's performance during a period of 6 minutes of continuous chest compressions. Methodology: Descriptive-correlational study, with a sample of 38 professionals experienced in resuscitation. Fatigue was assessed through capillary blood lactate levels; physical fitness through strength tests and body composition; and the rescuer's performance through the percentage of correct compressions per minute, which were performed in manikin. Results: The percentage of correct compressions decreased every minute (p<.05). The lactate levels increased from a baseline value of 1.7±.7mmol/L to 5.4±1.5mmol/L, and remained high after 20 minutes of rest. Grip strength, and muscle strength and mass of the trunk and upper limbs were positively correlated with the percentage of correct chest compressions. Conclusion: The body mass index and the physical fitness components - muscle strength and mass - were the variables that best explained the quality of the heart massage over time.

https://doi.org/10.12707/RIV15061 1643 downloads

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