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au:Pimentel, Maria Fernanda

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Determination of Total Mercury in Spanish Samples of Baby Food, Fast Food, and Daily Meal
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Silva, Maria J. da

; Paim, Ana Paula S.

; Silva, Iago J. S. da

; Pimentel, Maria Fernanda

; Cervera, Maria Luisa

; Guardia, Miguel de la

Journal of the Brazilian Chemical Society

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apr 2023, Volume 34 N. 4 Pages 517 - 526

Abstract: En | Text: En | PDF: En

This study determined the levels of total mercury in Spanish samples of baby food, fast food, and daily meal, which people of different ages consume, to evaluate potential toxicological risks through the contribution to the tolerable daily intake (TDI). The total mercury concentrations were determined in thirteen commercial baby foods for infants 6 to 12 months old, six types of fast foods prepared for children, and nine canteen menus prepared for adults. Samples were analyzed using a direct mercury analyzer, and the following concentration ranges were found: baby food (0.57-41.9 µg kg-1), fast food (0.54-68 µg kg-1), and adult menus (0.43-638 µg kg-1). The recovery of different amounts of spiked mercury ranged from 98.6 to 104.9%, and the method’s accuracy was checked with an analysis of different certified reference materials. The limits of detection and quantification obtained were 0.1 and 0.3 µg kg-1, respectively, with a relative standard deviation of up to 11%. The contribution of the samples to the TDI varied as follows: baby food (0.3-28%), fast food (0.5-102%), and adult menus (0.3-396%). Therefore, it was concluded that total mercury daily intake does not pose risks for Spanish children and adults if tuna is not included on their menu.

https://doi.org/10.21577/0103-5053.20220125

Análise da fluência por compressão no isolamento ao ruído de impacto de placas cimentícias com resíduo de EVA
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Santos, Fabianne Azevedo dos

; Melo, Aluísio Braz de

; Pimentel, Roberto Leal

; Oliveira, Maria Fernanda de

Ambiente Construído

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dec 2022, Volume 22 N. 1 Pages 125 - 138

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Os ruídos de impacto nas edificações multipavimentos são reduzidos com a execução de piso flutuante, caracterizado pela inclusão de um material resiliente entre o contrapiso e a laje. Nesse estudo, buscou-se avaliar a influência da compressão desse material no desempenho acústico do sistema. Dois materiais resilientes foram comparados, um produzido em laboratório (placas cimentícias com resíduos EVA -PEVA1,8), e outro comercial (manta recicladas de resíduos PET - MantaPET). As medições visando relacionar a rigidez dinâmica dos materiais e o desempenho acústico ocorreram em três anos. Adicionalmente, foram feitas estimativas de comportamento para dez anos, baseando-se em modelos teóricos e teste de fluência à compressão. Enquanto a PEVA1,8 apresentou redução em sua rigidez dinâmica (20,0MN/m³ para 17,7 MN/m³) ao longo do tempo, a MantaPET teve aumento nesse parâmetro (2,0 MN/m³ para 3,5 MN/m³), porém ambas mantiveram o desempenho intermediário (conforme NBR 15575-3:2013) ao ruído de impacto, com L’nT,w igual a 60 dB e 56 dB em um piso de testes respectivamente. As estimativas para dez anos indicaram deformação menor para PEVA1,8 (3,42%)comparativamente à MantaPET (20,15%) e confirmaram a tendência de variação distinta na rigidez dinâmica, sem comprometimento do desempenho acústico desses materiais.

Abstract Impact noise in multi-floor buildings is reduced with the execution of a floating floor, which has a resilient material between the subfloor and the slab. In this study, the evaluation of the influence of compression of this material on the acoustic performance of the system was sought. Two resilient materials were compared, one being produced in the laboratory (cementitious plates with EVA - PEVA1,8 waste), and the other commercially (blanket recycled from PET waste - MantaPET). The measurements aiming to relate the dynamic stiffness of the materials and the acoustic performance were up to three years. Additionally, estimates were made for ten years, based on theoretical models and creep compression tests. While PEVA1,8 decreased its dynamic stiffness (20.0 MN/m³ to 17.7 MN/m³) over time, MantaPET increased (2.0 MN/m³ to 3.5 MN/m³), but both maintained intermediate performance (according to NBR 15575-3:2013) to impact noise, presenting L’ nT,w equal to 60 dB and 56 dB in a test floor, respectively. Estimates for ten years indicated less deformation for PEVA1,8 (3.42%), compared to MantaPET (20.15%) and confirmed the trend of changes in the dynamic stiffness, without compromising the acoustic performance of these materials.

https://doi.org/10.1590/s1678-86212022000100582 41 downloads

Perceived racism or racial discrimination and the risk of adverse obstetric outcomes: a systematic review
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Pereira, Glaucia Miranda Varella

; Pimentel, Veronica Maria

; Surita, Fernanda Garanhani

; Silva, Amanda Dantas

; Brito, Luiz Gustavo Oliveira

Sao Paulo Medical Journal

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oct 2022, Volume 140 N. 5 Pages 705 - 718

Abstract: En | Text: En | PDF: En

ABSTRACT BACKGROUND: Racial disparities are differences among distinct subgroups of the human species; biologically, there are no scientifically proven reasons for them to exist. OBJECTIVE: To assess the impact of racism or racial discrimination on obstetric outcomes. DESIGN AND SETTING: Systematic review conducted at a tertiary/academic hospital. METHODS: The Cochrane Library, SCOPUS/EMBASE, PubMed, Web of Science and ClinicalTrials.gov databases were searched from inception to June 2020. Studies presenting any type of racial discrimination, or any manifestation of racism that was perceived by women of any age in an obstetric scenario were included. Studies that only assessed racial disparities without including direct racism were excluded. The secondary outcomes evaluated included quality of antenatal care, intra and postpartum care, preterm birth and birthweight. The Risk of Bias In Non-randomized Studies - of Interventions (ROBINS-I) scale was used to assess the quality of evidence from non-randomized studies. RESULTS: A total of 508 records were retrieved and 29 were selected for qualitative synthesis. No meta-analysis could be performed due to the high heterogeneity across studies. Perceived racism was associated as a risk factor in 7/10 studies focusing on pregnancy and postpartum maternal outcomes, five studies on preterm birth, one study on small for gestational age and two studies on low birthweight. Overall, among the 29 studies, the risk of bias was classified as moderate. CONCLUSIONS: Perceived racism presented an association with poor obstetric outcomes. Anti-racist measures are needed in order to address the problems that are causing patients to perceive or experience racism. SYSTEMATIC REVIEW REGISTRATION: PROSPERO database, CRD42020194382

https://doi.org/10.1590/1516-3180.2021.0505.r1.07042022

Brazilian practice guidelines for stroke rehabilitation: part II
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Minelli, Cesar

; Luvizutto, Gustavo José

; Cacho, Roberta de Oliveira

; Neves, Luciana de Oliveira

; Magalhães, Sheila Cristina Sayuri Abe

; Pedatella, Marco Túlio Araújo

; Mendonça, Lucia Iracema Zanotto de

; Ortiz, Karin Zazo

; Lange, Marcos Christiano

; Ribeiro, Priscila Watson

; Souza, Luciane Aparecida Pascucci Sande de

; Milani, Cristiano

; Cruz, Daniel Marinho Cezar da

; Costa, Rafael Dalle Molle da

; Conforto, Adriana Bastos

; Carvalho, Fernanda Martins Maia

; Ciarlini, Bruna Silva

; Frota, Norberto Anizio Ferreira

; Almeida, Kelson James

; Schochat, Eliane

; Oliveira, Tatiana de Paula

; Miranda, Camila

; Piemonte, Maria Elisa Pimentel

; Lopes, Laura Cardia Gomes

; Lopes, Camila Galvão

; Tosin, Michelle Hyczy de Siqueira

; Oliveira, Bianca Campos

; Oliveira, Beatriz Guitton Renaud Baptista de

; Castro, Shamyr Sulyvan de

; Andrade, João Brainier Clares de

; Silva, Gisele Sampaio

; Pontes-Neto, Octávio Marques

; Carvalho, João José Freitas de

; Martins, Sheila C. Ouriques

; Bazan, Rodrigo

Arquivos de Neuro-Psiquiatria

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jul 2022, Volume 80 N. 7 Pages 741 - 758

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

Abstract The Brazilian Practice Guidelines for Stroke Rehabilitation – Part II, developed by the Scientific Department of Neurological Rehabilitation of the Brazilian Academy of Neurology (Academia Brasileira de Neurologia, in Portuguese), focuses on specific rehabilitation techniques to aid recovery from impairment and disability after stroke. As in Part I, Part II is also based on recently available evidence from randomized controlled trials, systematic reviews, meta-analyses, and other guidelines. Part II covers disorders of communication, dysphagia, postural control and balance, ataxias, spasticity, upper limb rehabilitation, gait, cognition, unilateral spatial neglect, sensory impairments, home rehabilitation, medication adherence, palliative care, cerebrovascular events related to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, the future of stroke rehabilitation, and stroke websites to support patients and caregivers. Our goal is to provide health professionals with more recent knowledge and recommendations for better rehabilitation care after stroke.

Resumo As Diretrizes Brasileiras de Reabilitação do Acidente Vascular Cerebral (AVC) - Parte II, desenvolvida pelo Departamento Científico de Reabilitação Neurológica da Academia Brasileira de Neurologia é voltada para intervenções específicas de técnicas de reabilitação de déficits neurológicos e incapacidades. Seguindo o mesmo modelo da Parte I, a Parte II também se baseia em estudos randomizados, revisões sistemáticas, metanálises e outras diretrizes sobre o mesmo tema. A segunda parte aborda os distúrbios da comunicação, disfagia, controle postural e equilíbrio, ataxias, espasticidade, reabilitação do membro superior, marcha, cognição, negligência espacial unilateral, déficits sensoriais, reabilitação domiciliar, aderênciaao usode medicamentos, cuidados paliativos,ofuturodareabilitação no AVC, e websites de orientação sobre AVC para pacientes e cuidadores. Nosso objetivo é fornecer aos profissionais envolvidos na reabilitação conhecimento atualizado e recomendações para um melhor cuidado no pós-AVC.

https://doi.org/10.1055/s-0042-1757692

Phytochemical and pharmacological reports of the hypoglycemic activity of the Moringa oleifera extracts
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Santos, Ariana da Silva

; Pimentel, Anderson Lopes

; Oliveira, João Victor Lessa de

; Silva, Michelle Teixeira da

; Silva, Fernanda Geny Calheiros

; Borges, Arthur Luy Tavares Ferreira

; Moura, Maria Aline Fidelis Barros de

; Silva, Sâmia Andrícia Souza da

; Nascimento, Ticiano Gomes do

Rodriguésia

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2022, Volume 73 elocation e01262021

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Moringa oleífera Lam. é uma planta arbórea pertencente à família Moringaceae distribuída em áreas tropicais e que tem ganhado enorme atenção nas últimas décadas. Esta pesquisa é uma revisão sobre a associação entre extratos aquosos de folhas de M. oleifera e diabetes mellitus e compreender suas funções farmacológicas e mecanismos subjacentes. O refinamento da pesquisa demonstrou o potencial farmacêutico da M. oleifera e seus fitoquímicos, dado seu efeito antidiabético. A análise prospectiva mostrou a quantidade de aplicação dentro do IPC A61K na área da saúde. Os metabólitos secundários presentes em M. oleifera, glucosinolatos, flavonóides e compostos fenólicos podem ser responsáveis, em parte, pelas ações hipoglicemiantes de controle da doença. Os glucosinolatos, quando metabolizados por enzimas salivares, dão origem a sulforafanos que atuam na prevenção do diabetes tipo 2 e na redução da resistência à insulina. Os flavonóides interagem com as enzimas intestinais modificando o metabolismo dos carboidratos, regulando os níveis glicêmicos, além de aumentar a sensibilidade à insulina. Os compostos fenólicos aumentam a expressão dos transportadores de glicose (GLUT4) e reduzem a síntese de ácidos graxos e colesterol, contribuindo para a redução da resistência à glicose e controle da glicemia. Moringa oleifera pode ser usada como terapia complementar do diabetes tipo 2.

Abstract Moringa oleifera is an arboreal plant belonging to the family Moringaceae distributed in tropical areas and has gained enormous attention in the last decades. This research is a review on the association between aqueous extracts of M. oleifera leaves and diabetes mellitus and understanding its pharmacological functions and underlying mechanisms. The research refinement demonstrated the pharmaceutical potential of M. oleifera and its phytochemicals, given its antidiabetic effect. The prospective analysis showed the amount of application within IPC A61K in health area. The secondary metabolites present in M. oleifera, glucosinolates, flavonoids, and phenolic compounds may be responsible, in part, for the disease control hypoglycemic actions. Glucosinolates, when metabolized by salivary enzymes, give rise to sulforaphanes that act in preventing type 2 diabetes and in reducing insulin resistance. Flavonoids interact with intestinal enzymes by modifying carbohydrate metabolism by regulating glycemic levels, in addition to increasing insulin sensitivity. Phenolic compounds increase the expression of glucose transporters (GLUT4) and reduce the synthesis of fatty acids and cholesterol, contributing to the reduction of glucose resistance and blood sugar control. Moringa oleifera can be used as complementary therapy of the type-2 diabetes.

https://doi.org/10.1590/2175-7860202273090

Recommendations by the Scientific Department of Neuroimmunology of the Brazilian Academy of Neurology (DCNI/ABN) and the Brazilian Committee for Treatment and Research in Multiple Sclerosis and Neuroimmunological Diseases (BCTRIMS) on vaccination in general and specifically against SARS-CoV-2 for patients with demyelinating diseases of the central nervous system
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Becker, Jefferson

; Ferreira, Lis Campos

; Damasceno, Alfredo

; Bichuetti, Denis Bernardi

; Christo, Paulo Pereira

; Callegaro, Dagoberto

; Peixoto, Marco Aurélio Lana

; Sousa, Nise Alessandra De Carvalho

; Almeida, Sérgio Monteiro De

; Adoni, Tarso

; Santiago-Amaral, Juliana

; Junqueira, Thiago

; Pereira, Samira Luisa Apóstolos

; Gomes, Ana Beatriz Ayroza Galvão Ribeiro

; Pitombeira, Milena

; Paolilo, Renata Barbosa

; Grzesiuk, Anderson Kuntz

; Piccolo, Ana Claudia

; D´Almeida, José Arthur Costa

; Gomes Neto, Antonio Pereira

; Oliveira, Augusto Cesar Penalva De

; Oliveira, Bianca Santos De

; Tauil, Carlos Bernardo

; Vasconcelos, Claudia Ferreira

; Kaimen-Maciel, Damacio

; Varela, Daniel

; Diniz, Denise Sisterolli

; Oliveira, Enedina Maria Lobato De

; Malfetano, Fabiola Rachid

; Borges, Fernando Elias

; Figueira, Fernando Faria Andrade

; Gondim, Francisco De Assis Aquino

; Passos, Giordani Rodrigues Dos

; Silva, Guilherme Diogo

; Olival, Guilherme Sciascia Do

; Santos, Gutemberg Augusto Cruz Dos

; Ruocco, Heloisa Helena

; Sato, Henry Koiti

; Soares Neto, Herval Ribeiro

; Cortoni Calia, Leandro

; Gonçalves, Marcus Vinícius Magno

; Vecino, Maria Cecilia Aragón De

; Pimentel, Maria Lucia Vellutini

; Ribeiro, Marlise De Castro

; Boaventura, Mateus

; Parolin, Mônica Koncke Fiuza

; Melo, Renata Brant De Souza

; Lázaro, Robson

; Thomaz, Rodrigo Barbosa

; Kleinpaul, Rodrigo

; Dias, Ronaldo Maciel

; Gomes, Sidney

; Lucatto, Simone Abrante

; Alves-Leon, Soniza Vieira

; Fukuda, Thiago

; Ribeiro, Taysa Alexandrino Gonsalves Jubé

; Winckler, Thereza Cristina D’ávila

; Fragoso, Yara Dadalti

; Nascimento, Osvaldo José Moreira Do

; Ferreira, Maria Lucia Brito

; Mendes, Maria Fernanda

; Brum, Doralina Guimarães

; Glehn, Felipe Von

Arquivos de Neuro-Psiquiatria

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nov 2021, Volume 79 N. 11 Pages 1049 - 1061

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO O DC de Neuroimunologia da ABN e o BCTRIMS trazem, nesse documento, as recomendações sobre vacinação da população com doenças desmielinizantes do sistema nervoso central (SNC) contra infecções em geral e contra o coronavírus da síndrome respiratória aguda grave 2 (SARS-CoV-2), causador da COVID-19. Destaca-se a gravidade do atual momento frente ao avanço da COVID-19 em nosso País, o que torna mais evidente e importante a criação de guia de referência para orientação aos médicos, pacientes e autoridades de saúde pública quanto à vacinação, meio efetivo e seguro no controle de determinadas doenças infecciosa. O DCNI/ABN e o BCTRIMS recomendam que os pacientes com doenças desmielinizantes do SNC (ex., EM e NMOSD) sejam constantemente monitorados, quanto a atualização do seu calendário vacinal, especialmente, no início ou antes da mudança do tratamento com uma droga modificadora de doença (DMD). É importante também salientar que as vacinas são seguras e os médicos devem estimular o seu uso em todos os pacientes. Evidentemente, deve ser dada especial atenção às vacinas com vírus vivos atenuados. Por fim, é importante que os médicos verifiquem qual DMD o paciente está em uso e quando foi feita a sua última dose, pois cada fármaco pode interagir de forma diferente com a indução da resposta imune.

ABSTRACT The Scientific Department of Neuroimmunology of the Brazilian Academy of Neurology (DCNI/ABN) and Brazilian Committee for Treatment and Research in Multiple Sclerosis and Neuroimmunological Diseases (BCTRIMS) provide recommendations in this document for vaccination of the population with demyelinating diseases of the central nervous system (CNS) against infections in general and against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes COVID-19. We emphasize the seriousness of the current situation in view of the spread of COVID-19 in our country. Therefore, reference guides on vaccination for clinicians, patients, and public health authorities are particularly important to prevent some infectious diseases. The DCNI/ABN and BCTRIMS recommend that patients with CNS demyelinating diseases (e.g., MS and NMOSD) be continually monitored for updates to their vaccination schedule, especially at the beginning or before a change in treatment with a disease modifying drug (DMD). It is also important to note that vaccines are safe, and physicians should encourage their use in all patients. Clearly, special care should be taken when live attenuated viruses are involved. Finally, it is important for physicians to verify which DMD the patient is receiving and when the last dose was taken, as each drug may affect the induction of immune response differently.

https://doi.org/10.1590/0004-282x-anp-2021-0162 1 downloads

Cross-sectional survey for Toxoplasma gondii infection in humans in Fernando de Noronha island, Brazil
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Carvalho, Maria da Conceição

; Ribeiro-Andrade, Müller

; Melo, Renata Pimentel Bandeira de

; Guedes, Dandara Matias

; Pinheiro Junior, José Wilton

; Cavalcanti, Erika Fernanda Torres Samico Fernandes

; Magalhães, Fernando Jorge Rodrigues

; Mota, Rinaldo Aparecido

Revista Brasileira de Parasitologia Veterinária

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2021, Volume 30 N. 3 elocation e005121

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo A toxoplasmose, causada pelo protozoário Toxoplasma gondii, é uma zoonose e uma das doenças parasitárias transmitidas por alimentos mais importantes em todo o mundo. A prevalência em humanos é altamente variável, sendo influenciada por hábitos culturais, condições socioeconômicas e ambientais. O objetivo deste estudo foi estimar a prevalência de infecção por T. gondii em humanos, no arquipélago de Fernando de Noronha, Pernambuco, Brasil, e identificar os fatores de risco associados a essa infecção nesse contexto insular. A soroprevalência de anticorpos IgG anti-T. gondii nos ilhéus foi de 50,4% (172/341, 95% CI: 45,2%–55,7%). Os fatores associados à infecção encontrados foram o consumo de água do poço ou de água da chuva (Odds ratio [OR]: 2,43, p=0,020) e consumo de carne de caça (OR: 1,80, p=0,026). Este é o primeiro estudo a fornecer informações epidemiológicas da infecção por T. gondii entre os moradores da Ilha de Fernando de Noronha, revelando uma considerável soroprevalência de anticorpos nessa população. Este estudo fornece informações para subsidiar a adoção de medidas de prevenção e controle em ambientes insulares.

Abstract Toxoplasmosis, caused by the protozoan Toxoplasma gondii, is zoonotic disease and is one of the most important foodborne parasitic diseases globally. The prevalence in humans is highly variable, being influenced by cultural habits, socioeconomic, and environmental conditions. The objective of this study was to estimate the prevalence of T. gondii infection in humans on the archipelago of Fernando de Noronha, Pernambuco State, Brazil, and to identify the risk factors associated with this infection. The seroprevalence of immunoglobulin G anti-T. gondii antibodies was 50.4% (172/341, 95% CI: 45.2%–55.7%). Factors associated with the infection were consumption of well water or rainwater (odds ratio [OR]: 2.43, p=0.020) and consumption of game meat (OR: 1.80, p=0.026). This is the first study to provide epidemiological information of T. gondii infection among the residents of the Island of Fernando de Noronha, revealing a considerable antibody seroprevalence in this population. This study provides information for the adoption of prevention and control measures in island environments.

https://doi.org/10.1590/s1984-29612021062 213 downloads

Determination of Ethanol in Gel Hand Sanitizers Using Mid and Near Infrared Spectroscopy
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Fonseca Jr., Fernando S.

; Brito, Lívia R. e

; Pimentel, Maria Fernanda

; Leal, Leila B.

Journal of the Brazilian Chemical Society

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sep 2020, Volume 31 N. 9 Pages 1759 - 1763

Abstract: En | Text: En | PDF: En

Alcohol-based gel hand sanitizers became very popular during the COVID-19 (coronavirus disease 2019) pandemic. In Brazil, several irregular factories emerged requiring an efficient control by the police and regulatory agencies to guarantee product quality. This problem required a method to determine ethanol content, which led to the development of two methods employing mid and near infrared spectroscopy associated with chemometrics. Partial least squares (PLS) models were built and presented satisfactory results with mean absolute percentage error of prediction and root mean square error of prediction (RMSEP) of 1.12 and 0.76% (m/m), respectively, for mid-infrared (MIR) and 1.83 and 1.18% (m/m) for near-infrared (NIR). The analysis of commercial and seized samples of hand sanitizers showed that only 7 out of 34 samples had an ethanol content of 70% (m/m) or higher. This result reinforces the need for constant vigilance by authorities to ensure that the products have the required specifications.

https://doi.org/10.21577/0103-5053.20200115 2243 downloads

Leishmaniasis Mucocutánea con Manifestacion Oral: Reporte de un Caso
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Molina-Avila, Ignacio Javier

; Pimentel-Sola, Juan Martin

; García-Bustos, María Fernanda

; Pimentel-Sola, Julia

; Marco-Jorge, Diego

; Brunetto, Guadalupe

; Córdoba, Mauree

; Cordero-Torres, Karina

International journal of odontostomatology

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sep 2020, Volume 14 N. 3 Pages 342 - 347

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

ABSTRACT: Leishmaniasis is a group of vector-borne diseases caused by Leishmania, an intracellular parasite, which occurs preferentially in tropical and subtropical regions. It manifests itself through a wide range of clinical forms such as cutaneous, mucocutaneous, and visceral, depending on the species and the patient's immune response. We present a case of a 35-year-old man who was referred to the Stomatology Unit of the Señor del Milagro Hospital, Salta, Argentina, presenting in the oral cavity lesion, granulomatous, ulcerated, painful on palpation, unique, soft palate with three months of evolution. Serological, parasitological and PCR studies were performed. Lysed ELISAs, PCRs and cultures of lesion materials were positive, confirming diagnosis of mucocutaneous leishmaniasis. The patient was referred to the Dermatology Service where he received treatment with Meglumine Antimony, with favorable clinical response. The knowledge of the oral manifestations can lead to the clinical diagnosis of mucocutaneous leishmaniasis by the dentist, being able to provide timely treatment and at the same time help the patient, avoiding complications of this disease.

RESUMEN: La Leishmaniasis es un grupo de enfermedades transmitidas por vectores y causada por la Leishmania, un parásito intracelular, que se presenta de preferencia en regiones tropicales y subtropicales. Se manifiesta mediante un amplio rango de formas clínicas como la cutánea, mucocutánea, y visceral, dependiendo de la especie y respuesta inmunológica del paciente. Se presenta el caso de un hombre de 35 años que acudió derivado a Unidad de Estomatología del Hospital Señor del Milagro, Salta, Argentina, presentando en la cavidad oral lesión, granulomatosa, ulcerada, dolorosa a la palpación, única, en paladar blando, de tres meses de evolución. Se realizaron estudios serológicos, parasitológicos y PCR. Los ELISAs lisados, PCRs y cultivos de materiales de lesiones fueron positivos, confirmando diagnóstico de leishmaniasis mucocutánea. El paciente fue derivado al Servicio de Dermatología donde recibió tratamiento con Antimoniato de Meglumina, con repuesta clínica favorable. El conocimiento de las manifestaciones orales puede llevar al diagnóstico clínico de leishmaniasis mucocutánea por parte del odontólogo, pudiendo entregar un tratamiento oportuno y a la vez ayudar al paciente, evitando complicaciones de esta enfermedad.

4395 downloads

10.

Role of Research and Development Institutions and AgTechs in the digital transformation of Agriculture in Brazil
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Romani, Luciana Alvim Santos

; Bariani, Joice Machado

; Drucker, Debora Pignatari

; Vaz, Glauber José

; Mondo, Vitor Henrique Vaz

; Moura, Maria Fernanda

; Bolfe, Edson Luis

; Sousa, Pedro Henrique Pimentel de

; Oliveira, Stanley Robson de Medeiros

; Luchiari Junior, Ariovaldo

Revista Ciência Agronômica

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2020, Volume 51 N. spe elocation e20207800

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO O agronegócio brasileiro vem se modernizando pela intensa adoção de tecnologias, com aumento de produtividade e redução de riscos. Mais recentemente, observa-se um crescente aumento no uso das tecnologias digitais no campo, fazendo emergir a chamada Agricultura Digital. Neste contexto, este artigo apresenta o Programa de Aceleração de startups, denominado TechStart Agro Digital, uma iniciativa da Embrapa Informática Agropecuária e da aceleradora Venture Hub com o apoio de vários atores do ecossistema de inovação agrícola. Este trabalho apresenta a metodologia de aceleração tecnológica e de negócios com foco no agronegócio, proposta pelas duas instituições, ilustrando sua aplicação no primeiro ciclo do programa em 2019. Os resultados demonstram que as 11 startups graduadas no Programa demonstraram um aperfeiçoamento e crescimento após os 6 meses de aceleração, viabilizando a proposição de tecnologias mais consolidadas e focadas nos reais problemas da agricultura. O acompanhamento pós-programa indica que estas AgTechs têm auxiliado o produtor rural, efetiva e eficazmente, agregando valor à agricultura brasileira.

ABSTRACT The Brazilian agribusiness sector has been witnessing increasing modernization, caused by the extensive adoption of technologies, with increase in productivity and reduction of risks In addition, the use of digital technologies in farms has recently been increasing, engendering the emerging field of digital agriculture. In this context, this article presents a startup acceleration program, called TechStart Agro Digital, an initiative of Embrapa Agricultural Informatics and Venture Hub with the support of various stakeholders in the agricultural innovation ecosystem. Further, this article presents a methodology for technological and business acceleration focused on agribusinesses, which was proposed by the two institutions, and its application in the first cycle of the program in 2019. The results show that the 11 startups that graduated from the program demonstrated an improvement and growth six months after the acceleration program, and validate the potential of the program in facilitating the development of technologies that are more consolidated and focused on the real problems of agriculture. The post-program follow-up indicates that these agricultural technology startups and organizations (AgTechs) have helped rural producers effectively and efficiently, thereby adding value to Brazilian agriculture.

https://doi.org/10.5935/1806-6690.20200082 63 downloads

11.

Rapid detection of Mycobacterium tuberculosis in children using blood and urine specimens
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Costa-Lima, Juliana Figueirêdo da

; Pimentel, Lílian Maria Lapa Montenegro

; Santos, Fabiana Cristina Fulco

; Salazar, Marcela Pereira

; Duarte, Rafael Silva

; Mello, Fernanda Carvalho de Queiroz

; Schindler, Haiana Charifker

Revista da Sociedade Brasileira de Medicina Tropical

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2020, Volume 53 elocation e20200051

Abstract: En | Text: En | PDF: En

Abstract INTRODUCTION: Laboratory and clinical features of childhood tuberculosis (TB) are non-specific and establishing an accurate diagnosis remains a challenge. This study evaluated a Single tube nested-PCR (STNPCR) to detect genomic DNA of Mycobacterium tuberculosis complex in blood and urine. METHODS: Biological samples were obtained from children (<15 years old) with clinical suspicion of pulmonary and extrapulmonary TB at public hospitals in Recife-Pernambuco, Brazil. Cultures yielded negative results in a majority of childhood TB cases, which are generally paucibacillary. A set of clinical, epidemiological, radiological, and laboratory criteria with evident clinical improvement after anti-TB treatment were frequently used to define childhood TB cases. RESULTS: Ninety children with clinical suspicion were enrolled in this study (44 with TB and 46 without TB). The pulmonary TB group had 20 confirmed cases and 46 negative controls, while the extrapulmonary TB group had 24 confirmed cases. The STNPCR showed sensitivities to pulmonary and extrapulmonary TB of 47.4% and 52.2% (blood) and 38.8% and 20% (urine), respectively. Considering the low performance of STNPCR on separate samples, we decided to perform a combined analysis (parallel sensitivity analysis) of the results from blood and urine samples. The parallel sensitivity increased to 65% in blood and 62.5% in urine. The specificity in both samples ranged from 93.5-97.8%. CONCLUSIONS: Although STNPCR showed moderate sensitivity, the specificity is high; therefore, the test can be used as an auxiliary tool to diagnose TB in children. It is a rapid test that demonstrated better performance than other diagnostic tests in paucibacillary samples as it does in childhood tuberculosis.

https://doi.org/10.1590/0037-8682-0051-2020 474 downloads

12.

Primer aislamiento de Candida auris en Chile
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Moreno, María Victoria

; Simian, María Elvira

; Villarroel, Javier

; Fuenzalida, Luz María

; Yarad, María Fernanda

; Soto, Andrés

; Silva, Verónica

; Pimentel, Ximena

Revista chilena de infectología

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dec 2019, Volume 36 N. 6 Pages 767 - 773

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

Candida auris is an emerging multi-drug-resistant fungus that is rapidly spreading worldwide. Since the first reports in 2009, many isolates across five continents have been identified as agents of hospital-associated infections. Independent and simultaneous outbreaks of C. auris are becoming a major concern for healthcare and scientific community. Moreover, laboratory misidentification and multi-drug-resistant profiles, rarely observed for other non-albicans Candida species, result in difficult eradication and frequent therapeutic failures of C. auris infections. In this article we present the first case of isolation of a strain of C. auris at a hospital in Santiago, in a patient coming from India, who was admitted for treatment of diabetic foot complications. The strain was recovered from a tissue culture and identified by VITEK® 2 Compact. The accurate identification of C. auris was confirmed by means of MALDI-TOF MS and DNA sequence analysis. The isolate was resistant to fluconazole, retaining only susceptibility to amphotericin and caspofungin with MIC breakpoints recommended by CDC. The emergence of C. auris is alarming because the mode of transmission within the healthcare environment is not clear and is likely to be multifactorial.

Resumen Candida auris es una levadura multi-resistente emergente con rápida diseminación mundial. Desde el primer reporte el 2009, varios aislados a través de los cinco continentes han sido identificados como agentes de infecciones asociadas a la atención en salud. Brotes independientes y simultáneos por C. auris se han vuelto prioridad para la comunidad hospitalaria y científica. Además, los errores en identificación y los perfiles de multi-resistencia, raramente observados para otras especies de Candida, resultan en una difícil erradicación y fallas terapéuticas frecuentes en infecciones por C. auris. Presentamos el primer aislamiento de una cepa de C. auris en un hospital en Santiago, en un paciente proveniente de la India, que fue admitido para tratamiento de su pie diabético. La cepa fue recuperada de un cultivo de tejido e identificada por VITEK® 2 Compact. La identificación de C. auris fue confirmada por MALDI-TOF MS y secuenciación. El aislado fue resistente a fluconazol y susceptible a anfotericina y caspofungina, según puntos de corte recomendados por el CDC. La emergencia de C. auris es alarmante debido a que el modo de transmisión dentro del ambiente hospitalario no es claro y probablemente es multifactorial.

2687 downloads

13.

Vibrational Spectroscopy and Chemometrics in Forensic Chemistry: Critical Review, Current Trends and Challenges
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Silva, Carolina S.

; Braz, André

; Pimentel, Maria Fernanda

Journal of the Brazilian Chemical Society

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nov 2019, Volume 30 N. 11 Pages 2259 - 2290

Abstract: En | Text: En | PDF: En

The present manuscript makes an extensive review of the scientific approaches developed in the last decade involving infrared and Raman spectroscopy combined with chemometrics for solving several issues in the investigation of the most relevant forensic traces, such as questioned documents and currency, explosives, gunshot residues, illicit drugs and body fluids. In addition, current trends, main challenges and the adequate use of several chemometric techniques are discussed. Principal component analysis (PCA) was found to be the most used technique. This unsupervised approach, however, has sometimes been misunderstood as a classification technique. Discriminant analysis techniques are widely employed, leaving a range of possibilities for application of class-modeling techniques, particularly in cases of problems regarding only one target class. In addition, increasingly complex dataset structures frequently require nonlinear approaches or flexible techniques such as multivariate curve resolution-alternating least squares (MCR-ALS). Results reporting, however, still lack reliable quality parameters and sample representativeness, posing a significant challenge to the solution of forensic problems. Regarding the analytical techniques, Raman has been playing an important role, especially in the area of questioned documents and of body fluids. Portable and hyperspectral imaging infrared spectrometers have also been showing significant potential in forensic applications.

https://doi.org/10.21577/0103-5053.20190140 1307 downloads

14.

Migraine in 746 patients with multiple sclerosis
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Fragoso, Yara Dadalti

; Adoni, Tarso

; Alves-Leon, Soniza V.

; Apostolos-Pereira, Samira L.

; Carneiro, Marcos A. Diniz

; Chikota, Edila M.

; Diniz, Denise Sisterolli

; Eboni, Audred C. B.

; Gomes, Sidney

; Gonçalves, Marcus Vinicius M.

; Goncalves, Ricardo Pereira

; Inojosa, José Luiz

; Junqueira, Thiago F.

; Machado, Suzana Costa

; Malfetano, Fabiola Rachid

; Mansur, Letícia Fezer

; Mendes, Maria Fernanda

; Muniz, Andre

; Nobrega Junior, Adaucto W.

; Olival, Guilherme Sciascia do

; Parolin, Monica Fiuza

; Pimentel, Maria Lucia V.

; Rocha, Cristiane Franklin

; Ruocco, Heloisa Helena

; Santos, Gutemberg C.

; Siquineli, Fabio

; Soares, José Otavio D.

; Sousa, Nise Alessandra C.

; Tauil, Carlos Bernardo

; Winckler, Thereza Cristina A.

Arquivos de Neuro-Psiquiatria

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sep 2019, Volume 77 N. 9 Pages 617 - 621

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Enxaqueca piora o sofrimento do paciente que tem esclerose múltipla (EM). ID-migraine é uma ferramenta útil para seleção de pacientes com enxaqueca e Migraine Disability Assessment (MIDAS) é um questionário que avalia o impacto da doença. O objetivo do presente estudo foi avaliar a presença e impacto de enxaqueca em pacientes com EM. Métodos: Pacientes diagnosticados com EM e tratados em clínicas especializadas foram convidados a responder um questionário online se também apresentassem cefaleia. Resultados: O estudo incluiu 746 participantes com cefaleia e EM que preencheram completamente as respostas. Foram 625 mulheres e 121 homens, sendo 69% dos pacientes com idade entre 20 e 40 anos. Enxaqueca foi identificada em 404 pacientes (54,1%) e moderado a grave impacto da doença foi observado em 68,3% dos casos. Conclusão: Enxaqueca é uma cefaleia primária frequente e incapacitante relatada por pacientes com EM.

ABSTRACT Migraine adds to the burden of patients suffering from multiple sclerosis (MS). The ID-migraine is a useful tool for screening migraine, and the Migraine Disability Assessment questionnaire can evaluate disease burden. The aim of the present study was to assess the presence and burden of migraine in patients with MS. Methods: Patients diagnosed with MS attending specialized MS units were invited to answer an online survey if they also experienced headache. Results: The study included 746 complete responses from patients with MS and headache. There were 625 women and 121 men, and 69% of all the patients were aged between 20 and 40 years. Migraine was identified in 404 patients (54.1%) and a moderate-to-high burden of disease was observed in 68.3% of the patients. Conclusion: Migraine is a frequent and disabling type of primary headache reported by patients with MS.

https://doi.org/10.1590/0004-282x20190100 1666 downloads

15.

Neoplasia de próstata en trabajadores expuestos al cadmio y/o sus compuestos: revisión sistemática
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Baines Camps, Ángela Kenia

; Levy Moshe, Alberto Daniel

; Visconti Pimentel, María Fernanda

; Sanz-Valero, Javier

Medicina y Seguridad del Trabajo

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mar 2019, Volume 65 N. 254 Pages 59 - 72

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

Abstract Introduction: Prostate neoplasm is the most common malignant disease in developing countries and the second cause of death worldwide. Objectives: To review the existing scientific literature on the appearance of prostate neoplasms associated with occupational exposure to cadmium and/or its compounds. Methods: Systematic review of the scientific literature collected in the MEDLINE bibliographic databases (via PubMed), The Cochrane Library, Scopus and Web of Science. The terms used, as descriptors and free text in title and summary, were: «Cadmium», «Cadmium Compounds», «Cadmium Radioisotopes», «Cadmium Isotopes», «Cadmium Chloride», «Cadmium Poisoning», «Itai Itai», «Prostatic Neoplasms», «Prostatic Neoplasm», «Prostate Neoplasm», «Prostate Cancer», «Cancer of the Prostate», «Prostatic Cancer», «Cancer of Prostate» and «Occupational Exposure». The filters (limits) «humans» and «adults» (19+ years) were considered. Results: 114 references were retrieved, 14 articles of them in full text after applying the inclusion and exclusion criteria, in which the association between occupational exposure to cadmium and the development of prostate neoplasm is explained. Conclusions: Despite the results obtained that evaluate the development of prostate cancer after exposure to cadmium or its compounds, not enough evidence to demonstrate its carcinogenic effect in the workplace has been found, so new studies that provide evidence in relation to this topic should be carried out.

Resumen Introducción: La neoplasia de próstata es la enfermedad maligna más común de los países desarrollados y la segunda causa de muerte a nivel mundial. Objetivos: Revisar la literatura científica existente sobre la aparición de neoplasias de próstata asociada a la exposición laboral al cadmio y/o sus compuestos. Métodos: Revisión sistemática de la literatura científica recogida en las bases de datos bibliográficas MEDLINE (vía PubMed), The Cochrane Library, Scopus y Web of Science. Los términos utilizados, como descriptores y texto libre en título y resumen, fueron: «Cadmium», «Cadmium Compounds», «Cadmium Radioisotopes», «Cadmium Isotopes», «Cadmium Chloride», «Cadmium Poisoning», «Itai Itai», «Prostatic Neoplasms», «Prostatic Neoplasm», «Prostate Neoplasm», «Prostate Cancer», «Cancer of the Prostate», «Prostatic Cancer», «Cancer of Prostate» y «Occupational Exposure». Se utilizaron los filtros (límites) «humanos» y «adultos» (19+ años). Resultados: Se recuperaron 114 referencias, de las que se pudieron obtener a texto completo 14 artículos tras aplicar los criterios de inclusión y exclusión. En ellos se describe la asociación entre exposición laboral al cadmio y el desarrollo de neoplasia de próstata. Conclusiones: A pesar de obtener unos resultados que evalúan el desarrollo de neoplasia de próstata tras la exposición al cadmio o a sus compuestos, no existe suficiente evidencia que demuestre su efecto carcinogénico en el ámbito laboral, por lo que serían necesarios nuevos estudios que aporten evidencia en relación a este tema.

https://doi.org/10.4321/s0465-546x2019000100059 628 downloads

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