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au:Pereira, Sabrina Francisco

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Nutritional diagnosis of ‘Montenegrina’ mandarin orchards at the southern Brazil
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Griebeler, Sabrina Raquel

; Gonzatto, Mateus Pereira

; Schwarz, Sergio Francisco

; Böettcher, Gerson Nestor

; Pauletti, Gabriel Fernandes

; Rota, Luciana Duarte

Revista Ceres

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jan 2023, Volume 70 N. 1 Pages 69 - 77

Abstract: En | Text: En | PDF: En

ABSTRACT The correct nutrition of orchards from fertilizer management directly influences fruit yield. Therefore, the objective was to evaluate the nutritional status of orchards of the ‘Montenegrina’ mandarin (Citrus deliciosa Tenore) grafted on Poncirus trifoliata Raf. in southern Brazil. The study included analyzes of soil and leaf tissue from 58 commercial orchards. More than 60% of the orchards were diagnosed with K and Mg insufficiency and more than 30% had an excess of N. There was an insufficiency in Mn and Zn of 60 and 96%, respectively, despite the levels of these micronutrients in the soil being high in both depths studied. In addition, no significant correlations were observed between the contents of a given nutrient in the soil and in the leaves, except for the Ca/Mg ratio. Insufficiency was observed in the leaf contents of K, Mg, Mn and Zn and excesses of N and Cu in the orchards. The use of phosphate and potassium fertilizers requires adjustments due to the excessive content of these nutrients in the soil. Pre-planting acidity correction and soil acidity management in ‘Montenegrina’ mandarin orchards already implanted needs to be optimized.

https://doi.org/10.1590/0034-737x202370010008

Successive applications of gibberellic acid in alternate bearing mandarins
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Griebeler, Sabrina Raquel

; Gonzatto, Mateus Pereira

; Böettcher, Gerson Nestor

; Schwarz, Sergio Francisco

Revista Brasileira de Fruticultura

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2023, Volume 45 elocation e-445

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

Abstract Gibberellins can promote the inhibition of floral induction in citrus in order to reduce alternate bearing. However, not much is known about the responsiveness of Citrus deliciosa to exogenous applications of gibberellic acid. Furthermore, the successive application of gibberellins is barely studied. The main objective of this work was to evaluate the effect of successive applications of gibberellic acid (GA3) on the reduction of spring flowering subsequent to low fruit load periods (off-year) in ‘Montenegrina’ and ‘Rainha’ mandarin trees, in southern Brazil. The treatments consisted of one to four successive applications of GA3 (40 mg L-1) with 21-day interval in off-year trees. Applications began in May and ended in July. There was a significant reduction in sprouting and flowering of ‘Montenegrina’ mandarin with more than two GA3 successive applications compared to the control. To ‘Rainha’ mandarin, only two GA3 applications reduced the sprouting and solely one GA3 application was enough to reduce sprouting in relation to the control. GA3 use reduced sprouting and flowering of Montenegrina and Rainha cultivars. The orchard age may be related to its level of alternate bearing and, therefore, to the greater or lesser sensitivity of gibberellin applications.

Resumo As giberelinas podem promover a inibição da indução floral em citros com intuito de reduzir a alternância de produção. Contudo, pouco se sabe sobre a responsividade de Citrus deliciosa às aplicações exógenas de ácido giberélico. Além disso, a aplicação sucessiva de giberelinas é pouco estudada. Desta forma, objetivou-se avaliar o efeito de aplicações sucessivas de ácido giberélico (AG3) sobre a redução do florescimento primaveril subsequente a safras de baixa carga de frutos (ano off) em tangerineiras ‘Montenegrina’ e ‘Rainha’, no Sul do Brasil. Os tratamentos consistiram em uma a quatro aplicações sucessivas de 40 mg L-1 de AG3, com intervalos de 21 dias, em plantas em ano off. O início das aplicações foi em maio, e o término, em julho. Houve redução significativa de brotação e de florescimento com mais de duas aplicações sucessivas de AG3 para a tangerineira ‘Montenegrina’ em relação ao controle. Para a tangerineira ‘Rainha’, apenas com duas aplicações de AG3, o florescimento foi reduzido, enquanto apenas uma aplicação já foi suficiente para reduzir a brotação em relação ao controle. O uso de AG3 reduz brotação e florescimento das cultivares Montenegrina e Rainha. A idade do pomar pode estar relacionada ao seu nível de alternância produtiva e, desta forma, à maior ou à menor sensibilidade a aplicações de giberelinas.

https://doi.org/10.1590/0100-29452023445

Anatomical studies of Brazilian Amazonian Isoëtes species: inferences on habitat adaptation
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Cavalheiro-Filho, Sergio Luís

; Campos, Naiara Viana

; Caldeira, Cecílio Frois

; Pereira, Jovani Bernardino de Souza

; Konno, Tatiana Ungaretti Paleo

; Matos, Sabrina Dias de

; Cavalcante, Allysson Buraslan

; Esteves, Francisco de Assis

; Martins, Rodrigo Lemes

; Gestinari, Lísia Mônica de Souza

Rodriguésia

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2023, Volume 74 elocation e00562023

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

Abstract Isoëtes is a cosmopolitan genus of aquatic lycophytes, containing more than 200 species. In Brazil, the genus comprises 29 species, with three occurring in Pará state, Amazon. Isoëtes cangae and I. serracarajensis are endemic to the ferruginous outcrops of Serra dos Carajás, and I. amazonica occurs on the inundated shores of the Tapajós River. Despite the great diversity of quillworts in South America, their anatomy remains unknown. This study discusses Brazilian Amazon species’ leaf and root anatomical traits in relation to habitat and genetic diversity. The amphibious I. amazonica and I. serracarajensis were observed to have similar stomata and cuticular ornamentations. Isoëtes cangae, a fully aquatic species, had smaller epidermal cells and a smooth cuticle and showed slight differences regarding the lacuna diaphragm. The genetically closer species from Carajás both lacked peripheral fiber strands on the leaves. Our study complements current knowledge regarding the morphoanatomy of Amazonian species and provides a better understanding of their biology, contributing to the development of conservation strategies for these species.

Resumo Isoëtes é um gênero cosmopolita de licófitas aquáticas, contendo mais de 200 espécies. No Brasil, o gênero compreende 29 espécies, e três delas ocorrem no estado do Pará, Amazônia. Isoëtes cangae e I. serracarajensis são endêmicas dos campos rupestres ferruginosos da Serra dos Carajás, e I. amazonica ocorre nas planícies de inundação do rio Tapajós. Apesar de sua grande diversidade na América do Sul, a anatomia dessas espécies ainda é desconhecida. Este estudo discute sobre os caracteres anatômicos das folhas e raízes das espécies de Isoëtes da Amazônia Brasileira, relacionando-os ao habitat e à sua diversidade genética. As espécies anfíbias I. amazonica e I. serracarajensis apresentaram estômatos e ornamentações cuticulares semelhantes. Isoëtes cangae, uma espécie aquática, apresentou células epidérmicas menores, cutícula lisa e demonstrou diferenças relacionadas aos diafragmas das lacunas. As espécies de Carajás, geneticamente mais próximas, não apresentaram feixes de fibras periféricas nas folhas. Nosso estudo complementa o conhecimento atual da morfoanatomia das espécies Amazônicas, e contribui com a melhor compreensão de sua biologia, subsidiando o desenvolvimento de estratégias de conservação para essas espécies.

https://doi.org/10.1590/2175-7860202374084

Parthenocarpy induction and reduction of seeds in fruits of 'Nadorcott' mandarin
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Gonzatto, Mateus Pereira

; Griebeler, Sabrina Raquel

; Almeida, Gustavo Klamer de

; Munhoz, Bruno de Oliveira

; Sulzbach, Manuela

; Schwarz, Sergio Francisco

Revista Ceres

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apr 2022, Volume 69 N. 2 Pages 167 - 172

Abstract: En | Text: En | PDF: En

ABSTRACT Mandarins commercialization at international market requires seedless fruit production in addition to its ideal organoleptic and visual quality. The objective of the work was to evaluate the efficiency of applications of gibberellic acid and of copper sulfate during anthesis in reducing the number of seeds and in the productive behavior of the 'Nadorcott' mandarin in the conditions of the southern Brazil. The experiment was performed in an orchard of 'Nadorcott' mandarin trees grafted on Poncirus trifoliata. Two applications were conducted at anthesis with different levels and combinations of gibberellic acid and copper sulfate. Also, net was used as one of the treatments to prevent pollination. Net treatment provided a high frequency of seedless fruits, with greater skin color, however with less production. Gibberellic acid applications increased linearly the frequency of seedless fruits and with a maximum of two seeds. Copper sulphate applications did not affect any evaluated characteristics. Sprays of gibberellic acid of 100 mg L-1 concentration reduce the number of seeds per fruit and increase parthenocarpy, without effect on fruit size and peel color.

https://doi.org/10.1590/0034-737x202269020006

Synthesis, characterization and utilization of a new series of 1,2,3-triazole derivatives to neutralize some toxic activities of Bothrops jararaca snake venom
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Amorim, Nayanna de Mello

; Pereira Junior, Luiz Carlos Simas

; Sanchez, Eladio Flores

; Aquino, Gabriel Alves de

; Ferreira, Vitor Francisco

; Ferreira, Sabrina Baptista

; Fuly, André Lopes

; Oliveira, Eduardo Coriolano de

Brazilian Journal of Pharmaceutical Sciences

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2022, Volume 58 elocation e201143

Abstract: En | Text: En | PDF: En

Abstract Snake envenomation is a public health problem, and while serum therapy prevents death, the local effects of venoms can lead to amputations or morbidities. Thus, alternative treatments deserve attention. In this study, we tested eight derivatives of 1,2,3-triazole against some toxic activities of Bothrops jararaca venom. The derivatives were synthesized, and their structures analyzed by infrared and nuclear magnetic resonance. After that, the ability of compounds to inhibit hemolysis, coagulation, proteolysis, hemorrhaging, edema, and lethal activities of B. jararaca venom was investigated. The derivatives were incubated with B. jararaca venom (incubation protocol), administered before (prevention protocol) or after (treatment protocol) injecting venom into the mice. Then, hemorrhaging assay occurred. As a result, most of the derivatives inhibited the activities, even if they were incubated, injected before or after B. jararaca venom. However, the derivatives TRI 07 and TRI 18 seemed to be the most efficient in impairing hemorrhaging. The derivatives showed a low drug score of toxicity based on an in silico technique. Therefore, the derivatives fulfilled physicochemical and biological requirements to become drugs, and they may be a brand new initiative for designing antivenom molecules to complement antivenom therapy to efficiently block tissue necrosis or any other local effects.

https://doi.org/10.1590/s2175-9790202x000x2e201143

Successive applications of gibberellic acid to reduce flowering of 'Montenegrina' mandarin in alternate bearing
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Griebeler, Sabrina Raquel

; Gonzatto, Mateus Pereira

; Böettcher, Gerson Nestor

; Schneider, Leonardo André

; Sulzbach, Manuela

; Gargioni, Eduarda Dorigatti

; Schwarz, Sergio Francisco

Pesquisa Agropecuária Brasileira

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2021, Volume 56 elocation e02303

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo: O objetivo deste trabalho foi avaliar o número de aplicações sucessivas de ácido giberélico (GA3), no período de outono-inverno, quanto a seu efeito na redução do florescimento, na primavera subsequente após períodos de baixa carga de frutos (ano “off”), em tangerineiras 'Montenegrina' (Citrus deliciosa). As aplicações sequenciais a 40 mg L-1 de GA3 foram testadas de uma a quatro vezes, com intervalos de 21 dias, com início no final de maio. O experimento foi realizado em delineamento de blocos ao acaso, com quatro tratamentos e controle, quatro repetições e uma planta por unidade experimental. Floração, brotação, tipos de brotos, frutificação e diâmetro dos frutos foram avaliados. A frutificação diminui exponencialmente com o aumento da intensidade de floração. O uso de GA3 em duas, três ou quatro aplicações sequenciais, de maio a junho, maio a julho e maio a agosto, reduz a intensidade de floração e brotação em plantas com produção alternada na primavera subsequente, o que aumenta os brotos mistos e reduz os brotos florais. O uso de quatro aplicações sequenciais de 40 mg L-1 de GA3 promove grande incremento na frequência de brotos campaneiros e favorece o aumento da fixação e do tamanho dos frutos.

Abstract: The objective of this work was to evaluate the number of successive applications of gibberellic acid (GA3), during the autumn-winter period, for its effect on the reduction of flowering, in the subsequent spring after periods of low fruit load (off-year), in 'Montenegrina' mandarin trees (Citrus deliciosa). Sequential applications at 40 mg L-1 GA3 were tested from one to four times, at 21-day intervals, beginning in the end of May. The experiment was carried out in a randomized complete block design, with four treatments and a control, four replicates, and one plant per experimental unit. Flowering, sprouting, types of shoots, fruit set, and fruit diameter were evaluated. The fruit set increases exponentially with the reduction of flowering intensity. The use of GA3 in two, three, or four sequential applications, from May to June, May to July, and from May to August, at 21-day intervals, reduces the intensity of flowering and sprouting of alternate bearing plants in the subsequent spring, increasing mixed shoots and reducing floral shoots. The use of four sequential applications of 40 mg L-1 GA3 promotes a great increase in the frequency of single flower terminal leafy shoots and favors the increase of fruit fixation and size.

https://doi.org/10.1590/s1678-3921.pab2021.v56.02303 69 downloads

Manejo de florestas naturais degradadas na Amazônia: estudo de caso sobre critérios de colheita
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Siviero, Marco Antonio

; Ruschel, Ademir Roberto

; Yared, Jorge Alberto Gazel

; Vieira, Sabrina Benmuyal

; Sales, Agust

; Pereira, José Francisco

; Aguiar, Osmar José Romeiro de

; Brienza Junior, Sílvio

; Pereira, Paulo Cezar Gomes

; Berberian, Ghaby Alves

; Contini, Karina Piekarski Siviero

Ciência Florestal

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mar 2020, Volume 30 N. 1 Pages 43 - 59

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Este trabalho trata de uma experiência inovadora em relação a critérios para colheita de árvores em floresta natural degradada na Amazônia. A pesquisa foi desenvolvida em 535,6 ha de floresta na Fazenda Shet, em Dom Eliseu - PA, usando a base de dados do censo florestal referente a árvores com DAP ≥ 25 cm. Os critérios para colheita das árvores consideraram, prioritariamente, os seguintes elementos: grau de sanidade, qualidade do fuste (2 e 3), diâmetro máximo a permanecer na floresta (DAP < 100 cm), árvores de menor diâmetro (25 ≥ DAP ≤ 55 cm), espécies com maior densidade de árvores por unidade de área, distribuição diamétrica, segundo o coeficiente de Liocourt, manutenção das espécies intensamente exploradas no passado e com população de árvores ≤ 0,15 arv.ha-1. Foram inventariadas 46.012 árvores, pertencentes a 106 espécies, e planejadas para colheita 23,19% (10.671 árvores), aos 12 anos após a exploração anterior. Baseando-se no planejamento da colheita e seguindo os critérios, a previsão de colheita em relação à população total inventariada teve como resultado: 2,16% árvores pelo critério de sanidade; 15,45% pela forma de fuste; 0,26% pelo diâmetro máximo; 93,93% pelo menor diâmetro; 57,5% pela densidade arbórea; e 5,04% pela manutenção das espécies. A colheita foi realizada em 98,79% das árvores com sanidade comprometida; 22,20% com fuste 2 e 3; 97,39% com diâmetro máximo; 95,02% com menor diâmetro; e 90,30% com maior densidade arbórea. Foram mantidas 98,14% das espécies Astronium lecointei, Cordia goeldiana, Copaifera sp., Hymenaea courbaril, Hymenolobium petraeum, Handroanthus serratifolius e Manilkara elata, intensivamente exploradas no passado, e 98,70% de outras 53 espécies com menor abundância (≤ 0,15 arv.ha-1). O planejamento da exploração seguindo os critérios de colheita propostos possibilitou a extração de árvores em ciclos de 10 a 12 anos, sendo um tempo menor que o previsto pela legislação. A manutenção da diversidade de espécies arbóreas e a conservação da floresta em pé, previstas com esses critérios técnicos, podem ser alternativas para o manejo florestal ecológica e economicamente viável.

Abstract This paper deals with an innovative experience regarding tree harvesting criteria in degraded natural forest in the Amazon. The research was carried out in 535.6 ha of forest at Fazenda Shet, in Dom Eliseu/PA state, using the database of forest census for trees with DBH ≥ 25 cm. Criteria for tree harvesting considered, as a priority, the following elements: degree of health, shape of stem (2 and 3), maximum diameter to remain in the forest (DBH = 100 cm), smaller diameter trees (25 ≥ DBH ≤ 55 cm), species with higher tree density per unit area, diameter distribution according to the Liocourt coefficient, maintenance of intensively exploited species in the past and tree population ≤ 0.15 arv.ha-1. A total of 46,012 trees belonging to 106 species were inventoried and planned for harvest 23.19% (10,671 trees) at 12 years after the previous harvest. Based on harvest planning and following the criteria, the harvest forecast in relation to the total inventoried population resulted in: 2.16% trees by the criterion of health; 15.45% for the shape of stem; 0.26% by the maximum diameter; 93.93% for the smallest diameter; 57.5% for the tree density; and 5.04% for the maintenance of the species. Harvesting was performed on 98.79% of trees with compromised health; 22.20% with stem 2 and 3; 97.39% with maximum diameter; 95.02% with smaller diameter; and 90.30% with higher tree density. Were kept 98.14% of the species Astronium lecointei, Cordia goeldiana, Copaifera sp., Hymenaea courbaril, Hymenolobium petraeum, Handrohanthus serratifolius and Manilkara elata, intensively exploited in the past, and 98.70% of 53 other species with less abundance (≤ 0.15 arv.ha-1). The exploration planning following the proposed harvesting criteria allowed the extraction of trees in cycles of 10 to 12 years, being a shorter time than the one foreseen by the legislation. The maintenance of tree species diversity and forest conservation, provided for with these technical criteria, may be alternatives to ecologically and economically viable forest management.

https://doi.org/10.5902/1980509825856 683 downloads

Safety and efficacy of fenproporex for obesity treatment: a systematic review
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Paumgartten, Francisco José Roma

; Pereira, Sabrina Schaaf Teixeira Costa

; Oliveira, Ana Cecilia Amado Xavier de

Revista de Saúde Pública

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2016, Volume 50 elocation 25

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO OBJETIVO Avaliar a evidência clínica de segurança e eficácia do Fenproporex para tratamento da obesidade. MÉTODOS Pesquisamos publicações em qualquer idioma nas bases Medline, Lilacs Cochrane Controlled Trials Register e também referências citadas por artigos e documentos relevantes. Dois autores avaliaram independentemente os estudos para inclusão e quanto ao risco de viés, dados coletados e precisão. Foram elegíveis estudos controlados com placebo que forneceram dados sobre a eficácia e segurança do Fenproporex para tratar a obesidade. RESULTADOS Apenas quatro estudos controlados preencheram critérios de inclusão. Um estudo placebo-controlado aleatorizado do Fenproporex foi encontrado nas bases eletrônicas. Três estudos controlados (em periódicos não indexados) foram identificados por buscas manuais. Pacientes com comorbidades (cardiovasculares ou outras) foram excluídos em todos os estudos. A duração dos estudos foi de 40 a 364 dias, com doses de 20 a 33,6 mg/d. Todos os estudos controlados encontraram maior perda de peso entre pacientes tratados com Fenproporex, comparados aos que receberam placebo, mas o efeito foi modesto. O Fenproporex causou reduções adicionais de peso de 4,7 kg (após um ano), 3,8 kg (após seis meses) e 1,55 kg (após dois meses), em média, em relação à dieta e exercício apenas (três ensaios). Insônia, irritabilidade e ansiedade foram os eventos colaterais mais frequentes nos quatro estudos. CONCLUSÕES Ensaios clínicos placebo-controlado aleatorizado do Fenproporex são escassos e os estudos controlados identificados apresentam importantes falhas metodológicas. Esses estudos sugerem que o Fenproporex é modestamente eficaz em promover perda de peso. Entretanto, eles não fornecem evidências de que o Fenproporex atenua a morbidade e mortalidade associada à obesidade. Esses estudos são insuficientes para avaliar o perfil risco-benefício do Fenproporex. Potencial de abuso e efeitos adversos do tipo anfetamínico são motivos de preocupação.

ABSTRACT OBJECTIVE To evaluate clinical evidence on the safety and efficacy of fenproporex for treating obesity. METHODS MEDLINE, LILACS and Cochrane Controlled Trials Register were searched as well as references cited by articles and relevant documents. Two authors independently assessed the studies for inclusion and regarding risk of bias, collected data, and accuracy. Eligible studies were all those placebo-controlled that provided data on the efficacy and safety of Fenproporex to treat obesity. RESULTS Only four controlled studies met the inclusion criteria. One randomized, placebo-controlled trial on Fenproporex was found on electronic databases. Three placebo-controlled studies (in non-indexed journals) were identified by hand-searching. Patients with cardiovascular and other comorbidities were excluded in all studies. Trials lasted from 40 to 364 days and doses ranged from 20 to 33.6 mg/d. All controlled studies found that weight loss among Fenproporex-treated patients was greater than that produced by the placebo, but drug effect was modest. Fenproporex produced additional weight reductions of 4.7 kg (one year), 3.8 kg (six months) and 1.55 kg (two months) in average, in relation to diet and exercise only (three trials). Insomnia, irritability, and anxiety were the most frequently reported side effects in the four studies. CONCLUSIONS There is a paucity of randomized, placebo-controlled trials on Fenproporex and those identified here present major methodological flaws. These studies suggest that Fenproporex is modestly effective in promoting weight loss. Nonetheless, they failed to provide evidence that it reduces obesity-associated morbidity and mortality. Data from these studies are insufficient to determine the risk-benefit profile of Fenproporex. Abuse potential and amphetamine-like adverse effects are causes for concern.

https://doi.org/10.1590/S1518-8787.2016050006208 2720 downloads

Safety and efficacy of fenproporex for obesity treatment: a systematic review
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Paumgartten, Francisco José Roma

; Pereira, Sabrina Schaaf Teixeira Costa

; Oliveira, Ana Cecilia Amado Xavier de

Revista de Saúde Pública

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2016, Volume 50 elocation 25

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

https://doi.org/10.1590/S1518-8787.2016050006208 821 downloads

10.

Comparação entre leituras de resistógrafo e imagens tomográficas na avaliação interna de troncos de árvores
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Rollo, Francisco Martins de Almeida

; Soave Junior, Mauro Angelo

; Viana, Sabrina Mieko

; Rollo, Luciana Cavalcante Pereira

; Couto, Hilton Thadeu Zarate do

; Silva Filho, Demóstenes Ferreira da

CERNE

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jun 2013, Volume 19 N. 2 Pages 331 - 337

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

A avaliação do risco de queda de árvores urbanas é uma tarefa complexa que demanda, sempre que possível, o auxílio de critérios e métodos confiáveis que possam fornecer informações mais precisas sobre o estado dos indivíduos avaliados. Dentre os instrumentos hoje utilizados, destaca-se o resistógrafo que permite a detecção de problemas biomecânicos das árvores, por meio de leituras de resistência à penetração de uma agulha. Recentemente, surgiu a técnica da tomografia de impulso para a detecção de podridão interna que se baseia no cálculo da velocidade de propagação das ondas mecânicas no interior do lenho, originando uma imagem tomográfica que permite observar áreas de maior e menor densidade correlacionadas à existência de lesões e processos de apodrecimento. A comparação desses dois métodos de avaliação de risco de queda foi feita com o intuito de avaliar a qualidade dos dados fornecidos pelo tomógrafo de impulso, analisando sua relação com os dados do resistógrafo. Obteve-se um modelo com alto coeficiente de determinação (R²) de 0,9977, mostrando que os dados fornecidos pelo tomógrafo possuem alta qualidade.

Risk assessment of tree falls is essential for urban management and demands reliable methods and criteria capable of providing accurate information on assessed individuals. Among the tools currently used, resistograph stands out since it enables the detection of biomechanical problems through readings of needle penetration resistance. Recently, impulse tomography has been used as advanced technology to detect inner rottenness based on measurements of energy propagation velocity in inner tissues, generating a tomographic image that highlights higher and lower density areas related to lesions and rot processes. We compared these two risk assessment methods of trees to evaluate data reliability generated from impulse tomography, contrasting its results with data from resistograph. We obtained a model with high determination coefficient (R²) of 0.9977, showing that data provided by impulse tomography are high quality and reliable.

4157 downloads

11.

In vitro and in vivo antimalarial activity and cytotoxicity of extracts, fractions and a substance isolated from the Amazonian plant Tachia grandiflora (Gentianaceae)
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Silva, Luiz Francisco Rocha e

; Lima, Emerson Silva

; Vasconcellos, Marne Carvalho de

; Aranha, Ellen Suzany Pereira

; Costa, David Siqueira

; Mustafa, Elba Vieira

; Morais, Sabrina Kelly Reis de

; Alecrim, Maria das Gracas Costa

; Nunomura, Sergio Massayoshi

; Struwe, Lena

; Andrade-Neto, Valter Ferreira de

; Pohlit, Adrian Martin

Memórias do Instituto Oswaldo Cruz

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jun 2013, Volume 108 N. 4 Pages 501 - 507

Abstract: En | Text: En | PDF: En

Tachia sp. are used as antimalarials in the Amazon Region and in vivo antimalarial activity of a Tachia sp. has been previously reported. Tachia grandiflora Maguire and Weaver is an Amazonian antimalarial plant and herein its cytotoxicity and antimalarial activity were investigated. Spectral analysis of the tetraoxygenated xanthone decussatin and the iridoid aglyone amplexine isolated, respectively, from the chloroform fractions of root methanol and leaf ethanol extracts was performed. In vitro inhibition of the growth of Plasmodium falciparum Welch was evaluated using optical microscopy on blood smears. Crude extracts of leaves and roots were inactive in vitro. However, chloroform fractions of the root and leaf extracts [half-maximal inhibitory concentration (IC50) = 10.5 and 35.8 µg/mL, respectively] and amplexine (IC50= 7.1 µg/mL) were active in vitro. Extracts and fractions were not toxic to type MRC-5 human fibroblasts (IC50> 50 µg/mL). Water extracts of the roots of T. grandiflora administered by mouth were the most active extracts in the Peters 4-day suppression test in Plasmodium berghei-infected mice. At 500 mg/kg/day, these extracts exhibited 45-59% inhibition five to seven days after infection. T. grandiflora infusions, fractions and isolated substance have potential as antimalarials.

https://doi.org/10.1590/S0074-02762013000400017 3041 downloads

12.

I Diretriz brasileira de miocardites e pericardites
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Montera, Marcelo Westerlund

; Mesquita, Evandro Tinoco

; Colafranceschi, Alexandre Siciliano

; Oliveira Jr., Amarino Carvalho de

; Rabischoffsky, Arnaldo

; Ianni, Barbara Maria

; Rochitte, Carlos Eduardo

; Mady, Charles

; Mesquita, Claudio Tinoco

; Azevedo, Clerio Francisco

; Bocchi, Edimar Alcides

; Saad, Eduardo Benchimol

; Braga, Fabiana Goulart Marcondes

; Fernandes, Fábio

; Ramires, Felix José Alvarez

; Bacal, Fernando

; Feitosa, Gilson Soares

; Figueira, Hélio Roque

; Souza Neto, João David de

; Moura, Lídia Ana Zytynski

; Campos, Luiz Antônio de Almeida

; Bittencourt, Marcelo Imbroinise

; Barbosa, Márcia de Melo

; Moreira, Maria da Consolação Vieira

; Higuchi, Maria de Lourdes

; Schwartzmann, Pedro

; Rocha, Ricardo Mourilhe

; Pereira, Sabrina Bernardez

; Mangini, Sandrigo

; Martins, Silvia Marinho

; Bordignon, Solange

; Salles, Vitor Agueda

Arquivos Brasileiros de Cardiologia

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2013, Volume 100 N. 4 Pages 01 - 36

Abstract: Pt | Text: Pt | PDF: Pt

https://doi.org/10.5935/abc.2013S004 110168 downloads Cited 3 times in SciELO

13.

Dental caries profile in Monte Negro, Amazonian state of Rondônia, Brazil, in 2008
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Bastos, Roosevelt Silva

; Silva, Ricardo Pianta Rodrigues

; Maia-Junior, Adelson Francisco

; Carvalho, Fábio Silva

; Merlini, Sabrina

; Caldana, Magali Lourdes

; Lauris, José Roberto Pereira

; Bastos, José Roberto Magalhães

Journal of Applied Oral Science

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oct 2010, Volume 18 N. 5 Pages 437 - 441

Abstract: En | Text: En | PDF: En

OBJECTIVE: This epidemiological survey assessed the dental caries profile in Monte Negro, a small town in the Amazonian state of Rondônia, Brazil, and its relationship with the northern region, national and global goals for oral health in the years 2000 and 2020. MATERIAL AND METHODS: The groups randomly examined were composed of individuals aged 5, 12, 15 to 19, 35 to 44, 65 to 74 years, living in both rural and urban areas. RESULTS: The means dft (standard deviation) and DMFT (standard deviation) for the groups were, respectively, 3.15 (3.12), 3.41 (2.69), 5.96 (4.19), 16.00 (7.30) and 25.96 (9.82). Caries-free individuals were 34.42%, 14.81% and 8.16% in the preschoolchildren, schoolchildren and adolescent groups, respectively. The Significant Caries Index percentages applied to the two younger groups were 6.65 and 6.70, and they increased to 32.00 in the individuals aged 65 to 74 years. Care Index percentages for adolescents, adults and elderly groups were, respectively, 29.40, 25.00 and 1.41. The dental caries profile in Monte Negro in 2008 shows that, 8 years after the year 2000, no FDI/WHO goal for any age settled in 1982 has been achieved. Dental caries increased with age and the main dental problem of adult and elderly groups was tooth loss. CONCLUSION: Oral health promotion and prevention of oral disease policies are urgent needs. Setting of oral health goals and targets to people living in Monte Negro or Amazonia to be pursuit and achieved in a near future is an important action to do because of the culture, sanitary conditions and socioeconomic aspects of this particular population.

2655 downloads Cited 2 times in SciELO

14.

Anti-diabetic effects of Campomanesia xanthocarpa (Berg) leaf decoction
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Vinagre, Anapaula Sommer

; Rönnau, Ângela Della'Santa Rubio Origuella

; Pereira, Sabrina Francisco

; Silveira, Lídia Uliano da

; Wiilland, Elenir de Fátima

; Suyenaga, Edna Sayuri

Brazilian Journal of Pharmaceutical Sciences

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jun 2010, Volume 46 N. 2 Pages 169 - 177

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

O objetivo deste trabalho foi identificar os efeitos do tratamento com o decocto das folhas de Campomanesia xanthocarpa Berg. (20 g/L), durante 3 semanas, sobre parâmetros fisiológicos, bioquímicos e histológicos de ratos normais e diabéticos induzidos por estreptozotocina. O diabete melito foi induzido uma semana antes de iniciar o tratamento experimental, pela administração IP de estreptozotocina (STZ, 70 mg/kg em tampão citrato, pH 4.5). Os ratos tratados com STZ apresentaram sintomas típicos de diabete: polifagia, polidipsia, hiperglicemia, hipertrigliceridemia e alterações histopatológicas no pâncreas, fígado e rim. O tratamento dos ratos diabéticos com o decocto diminuiu os níveis de glicose sanguínea, inibiu a degradação do glicogênio hepático e preveniu possíveis alterações histopatológicas no pâncreas e no rim. Nos ratos controles tratados com o decocto não foram verificadas diferenças significativas em relação aos controles tratados com água. Em conclusão, os resultados sugerem que o tratamento com o decocto das folhas de C. xanthocarpa leaf decoction (20 g/L) possa ser útil para o manejo do diabete melito, porém estudos farmacológicos e toxicológicos ainda são necessários.

The objective of this research was to identify the effects of 3-week treatment of normal and streptozotocin-induced diabetic rats using a leaf decoction of Campomanesia xanthocarpa Berg. (20 g/L) on physiological, biochemical and histological parameters. Streptozotocin (STZ, 70 mg/kg in citrate buffer, pH 4.5) was administered IP to induce experimental diabetes one week prior to the treatment. STZ caused typical diabetic symptoms: polydypsia, polyuria, polyphagia, hyperglycemia, hypertriglyceridemia and histopathological modifications in the pancreas, liver and kidney. The treatment of diabetic rats using the decoction decreased blood glucose levels, inhibited hepatic glycogen loss, and prevented potential histopathological alterations in the pancreas and kidneys. No differences were found between the control rats treated with the decoction and the control rats maintained on water only. In conclusion, these results suggest that C. xanthocarpa leaf decoction (20g/L) might be useful for diabetes mellitus management, but further pharmacological and toxicological studies are needed.

4792 downloads Cited 4 times in SciELO

15.

A compatibilidade estímulo-resposta como modelo para o estudo do comportamento motor
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Gawryszewski, Luiz de Gonzaga

; Lameira, Allan Pablo

; Ferreira, Fernanda Maciel

; Guimaraes-Silva, Sabrina

; Conde, Erick Francisco Quintas

; Pereira Jr., Antônio

Psicologia USP

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2006, Volume 17 N. 4 Pages 103 - 121

Abstract: Pt En Fr | Text: Pt En Fr | PDF: Pt | PDF: En | PDF: Fr

Quando um estímulo ocorre aleatoriamente à esquerda ou à direita do ponto de fi xação, a resposta é mais rápida quando o estímulo e a tecla de resposta estão do mesmo lado (condição compatível) do que quando estão em lados opostos (condição incompatível). Na tarefa de compatibilidade espacial, observa-se uma diferença entre os Tempos de Reação Manual (TRMs) nas condições compatível e incompatível da ordem de 30-40 ms. No Efeito Simon, embora o critério para a seleção da resposta seja a forma (ou a cor) do estímulo, a posição do estímulo também infl uencia o TRM, facilitando-o na condição compatível e lentifi cando-o na incompatível. O Efeito Simon pode ser invertido se a pessoa realiza testes incompatíveis previamente ao teste Simon, mostrando que associações de curto prazo, geradas pelos pareamentos incompatíveis modulam padrões de conexões estímulo-resposta baseados na memória de longo prazo.

When a visual stimulus is randomly displayed either to the left or to the right of the fixation point, manual response is faster when both the response key and the stimulus are located at the same side (compatible condition) than at opposite sides (incompatible condition). In a spatial compatibility task, a difference of 30-40 ms is found between the manual reaction times (MRT) of compatible and incompatible conditions. In the Simon effect, though the criterion to response selection is primarily stimulus shape (or color), the stimulus position also influences the MRT, either increasing it in the compatible condition or delaying it in the incompatible condition. The Simon effect can be inverted if the subject has recently performed incompatible tasks, showing that short-term memory processes elicited by the incompatible associations can modulate stimulus-response relationships based on long-term memory.

Quand un stimulus aparait aléatoirement à gauche ou a droite du point de fixation, la réponse est plus rapide lorsque le stimulus et le levier de réponse sont du même coté (condition compatible) que lorsque ceux-ci sont oposés (condition incompatible). Dans la tâche de compatibilité spatiale, la différence de temps de réaction manuel (TRMs) entre les conditions compatible et incompatible est de l´ordre de 30-40 ms. Dans l´effet Simon, bien que le critère de selection da réponse soit la forme (ou la couleur) du stimulus, la position du stimulus influence également le TRM, produisant une facilitation dans la condition compatible et un retard dans la condition incompatible. L´effet Simon peut être inverté si le sujet réalise des testes incompatibles préalablement au test Simon. Ceci démontre que les assocations à court terme, produites par les appariements incompatibles, modulent les types de connexions stimulus-réponse basés sur la mémoire à long terme.

7955 downloads Cited 2 times in SciELO

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