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Resumo Investigamos se os atletas olímpicos brasileiros vivem mais que a população em geral e se existem diferenças entre os tipos de esporte. Trata-se de um estudo de coorte retrospectivo com análise de dados secundários. Foram incluídos dados de atletas brasileiros de ambos os sexos, desde a 7ª edição (1920) até a 25ª edição (1992) dos Jogos Olímpicos Modernos. Detalhes sobre o sexo, data de nascimento, data de falecimento e esporte praticado foram registrados quando disponíveis. Foram feitas comparações entre atletas e controles de mesma idade da população em geral; e entre tipos de esporte (força/potência [SP] vs. resistência/misto [EM]). Os atletas olímpicos brasileiros vivem aprox. 8 anos a mais do que o esperado para a população geral correspondente à idade. No entanto, não houve diferenças na expectativa de vida entre atletas SP (68,8 anos) vs. EM (68,9 anos) (p>0,05). Os atletas olímpicos brasileiros vivem mais que o esperado pela população em geral. No entanto, não há diferenças entre atletas de diferentes modalidades esportivas.

Abstract We investigated if Brazilian Olympic athletes live longer than the general population, and if there are differences between the types of sport. This is a retrospective cohort study with secondary data analysis. Data from Brazilian athletes of both sexes were included, from the 7th edition (1920) to the 25th edition (1992) of the Modern Olympic Games. Details of sex, date of birth, date of death, and sport competed were recorded when available. Comparisons were made between athletes vs. age-matched controls from the general population; and between sport types (strength/power [SP] vs. endurance/mixed [EM]). Brazilian Olympic athletes live approx. 8 years longer than expected for the age matched general population. However, there were no differences in lifespan between SP (68.8 years) vs. EM (68.9 years) athletes (p>0.05). Brazilian Olympic athletes live longer than expected for the general population. However, there are no differences between athletes from different sport types.

Resumen Investigamos si los atletas olímpicos brasileños viven más que la población general y si existen diferencias entre los deportes. Este estudio de cohorte retrospectivo se realizó con análisis de datos secundarios. Se incluyeron datos de atletas brasileños de ambos sexos, desde la 7.ª edición (1920) hasta la 25.ª edición (1992) de los Juegos Olímpicos Modernos. Registramos detalles de género, fecha de nacimiento, fecha de defunción y deporte en el que compitieron, cuando estaban disponibles. Comparamos atletas con controles de la misma edad de la población general; y entre tipos de deporte (fuerza/potencia [FP] vs. resistencia/mixto [RM]). Los atletas olímpicos brasileños viven aproximadamente ocho años más de lo esperado para la población general de la misma edad. Sin embargo, no hubo diferencias en la esperanza de vida entre los atletas FP (68,8 años) vs. RM (68,9 años) (p>0,05). Los atletas olímpicos brasileños viven más de lo esperado para la población general. Sin embargo, no hay diferencias entre atletas de diferentes tipos de deporte.

https://doi.org/10.1590/1413-81232025301.16862023

Safety of two-dose schedule of COVID-19 adsorbed inactivated vaccine (CoronaVac; Sinovac/Butantan) and heterologous additional doses of mRNA BNT162b2 (Pfizer/BioNTech) in immunocompromised and immunocompetent individuals
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Miyaji, Karina Takesaki

; Ibrahim, Karim Yaqub

; Infante, Vanessa

; Moreira, Raquel Megale

; Santos, Carolina Ferreira dos Belizário, Juliana de Cássia Pinto, Maria Isabel de Moraes Marinho, Ana Karolina Barreto Berselli Pereira, Juliana Marquezi Mello, Liliane Saraiva de Silva, Vitor Gabriel Lopes da Sato, Paula Keiko Strabelli, Tânia Mara Varejão Ragiotto, Lucas Pacheco, Pedro Henrique Theotonio de Mesquita Braga, Patricia Emilia Loch, Ana Paula Precioso, Alexander Roberto Sartori, Ana Marli Christovam França, João Ítalo Lima, Marcos Alves de Ando, Mauricio Cesar Sampaio Rodrigues, Camila Cristina Martini Song, Alice Tung Wan Lara, Amanda Nazareth Belizário, Ana Cristina Lima, Anna Helena Simões Bortulucci de Zanetti, Ariane Cristina Barboza Paulo, Audrey Rose da Silveira Amancio de Rosa, Barbara Miranda dos Santos Moraes, Bruna Del Guerra de Carvalho Oliveira, Bruna Ribeiro de Picone, Camila de Melo Aranda, Carolina Sanches Troli, Carolinne Paioli Kokron, Cristina M. Terrabuio, Debora Raquel Benedita Abdala, Edson David Neto, Elias Nakanishi, Érika Yoshie Shimoda Lima, Fabiana Mascarenhas Souza Firmino, Fabio Batista Santos, Fernanda Barone Alves dos Bacal, Fernando Fatobene, Giancarlo Santana, Jaqueline Oliveira Kalil, Jorge Barbosa, Julia Gonçalves, Leandro Peres Otuyama, Leonardo Jun Pierrotti, Ligia Camera Compte, Livia Caroline Mariano Marinho, Livia Chaer, Livia Netto Seguro, Luis Fernando Azevedo, Luiz Sergio Ueda, Márcia Aiko Terreri, Maria Teresa Barros, Myrthes Anna Maragna Toledo Grecco, Octávio Sejas, Odeli Nicole Encinas Musqueira, Priscila Tavares Ito, Raquel Keiko de Luca Teixeira, Samia Silveira Souza Fidalgo, Serafim Costa, Silvia Figueiredo Campos, Silvia Vidal Fernandes, Tamiris Hinsching Rocha, Vanderson Geraldo Coelho, Vivian Caso

Revista do Instituto de Medicina Tropical de São Paulo

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2025, Volume 67 elocation e2

Abstract: En | Text: En | PDF: En

ABSTRACT Immunocompromised individuals were considered high-risk for severe disease due to SARS COV-2 infection. This study aimed to describe the safety of two doses of COVID-19 adsorbed inactivated vaccine (CoronaVac; Sinovac/Butantan), followed by additional doses of mRNA BNT162b2 (Pfizer/BioNTech) in immunocompromised (IC) adults, compared to immunocompetent/healthy (H) individuals. This phase 4, multicenter, open label study included solid organ transplant and hematopoietic stem cell transplant recipients, cancer patients and people with inborn errors of immunity with defects in antibody production, rheumatic, end-stage chronic kidney or liver disease, who were enrolled in the IC group. Participants received two doses of CoronaVac and additional doses of mRNA BNT162b2. Adverse reactions (AR) data were collected within seven days after each vaccination. Serious adverse events and of special interest (AESI) were monitored throughout the study. We included 241 immunocompromised and 100 immunocompetent subjects. Arthralgia, fatigue, myalgia, and nausea were more frequent in the IC group after CoronaVac. Following the first additional dose of mRNA BNT162, pain, induration, and tenderness at injection site, fatigue and myalgia were more frequent in the H group. A heart transplant recipient had a graft rejection temporally associated with the second CoronaVac dose, but there was no literature evidence of causal association. Four cases of AESI were considered related to the vaccine: three erythema multiforme after CoronaVac, all in IC participants, and one paresthesia after mRNA, in a H participant. Our findings were comparable to other studies that evaluated the safety of COVID-19 vaccines in different immunocompromised populations. Both vaccines were safe for immunocompromised participants.

https://doi.org/10.1590/s1678-9946202567002

Hydrodemolition and drill and blast: A new way to improve tunnel contour quality
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Santos, Rafael Pacheco dos

; Noronha, Marcos Aurélio Marques

; Faria, Patrícia de Oliveira

; Coliboro, Thiane Pereira Poncetta

REM - International Engineering Journal

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2025, Volume 78 N. 1 elocation e240014

Abstract: En | Text: En | PDF: En

Abstract Drill and Blast is one of the most utilized excavation methods due to its cost and adaptation capability. One undesirable feature, however, is the contour shape quality of the blasted cavity. It is usually larger and rougher than planned. This characteristic is related to the crack generated by blasting that propagates until it finds a discontinuity. Some methods for overbreak and roughness control are used but they are far from perfect. One option is to replace explosives with the High-Power Abrasive Water Jet (HPAWJ) Technique for rock cutting the perimeter; a necessary step before execution of the Pre-Splitting Technique. These two techniques can create one free surface, with good roughness, capable of avoiding the crack propagation during the blast process. In this article, through a qualitative comparative research, an adaptive cycle is proposed, based on Drill and Blast, that uses HPAWJ for cutting the perimeter. In addition to the improvement on the tunnel wall roughness, this change can reduce the excavation-damage zone and the overbreak, which leads to a reduction of the amounts of shotcrete and muck, consequently reducing the need for transportation.

https://doi.org/10.1590/0370-44672024780014

Quality of life in patients with strabismus: Assessment of the preoperative and postoperative psychosocial and functional aspects
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Dorninger, Ilse Elias Gomes

; Isaac, David Leonardo Cruvinel

; Taleb, Alexandre Chater

; Carvalho, Keila Monteiro de

; Ávila, Marcos Pereira de

Arquivos Brasileiros de Oftalmologia

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2025, Volume 88 N. 3 elocation e2024-0118

Abstract: En | Text: En | PDF: En

ABSTRACT Purpose: To determine the influence of strabismus and its surgical correction on the preoperative and postoperative functional and psychosocial aspects of patients being treated at the CEROF/UFG Strabismus Outpatient Clinic. Methods: This prospective cross-sectional study included 27 patients, aged >7 years that were divided into two groups (<18 years and >18 years). The AS 20 questionnaire is composed of two domains (psychosocial and functional). Each domain includes 10 questions, which should be answered using a 5-point Likert scale. The questionnaire was administered preoperatively and 3 months postoperatively. In patients aged <18 years, the questionnaire was concurrently administered to their parents and/or guardians. Results: Preoperatively, the average psychosocial and functional scores were 55 (p=0.01) and 57.5 (p=0.025), respectively, in adults, 70 (p=0.03) and 78.7 (p=0.16), respectively, in children and adolescents, and 46.2 (p=0.002) and 57.5 (p=0.003), respectively, in the parents and/or guardians. Postoperatively, the average psychosocial and functional scores were 80 (p=0.01) and 82.5 (p=0.025), respectively, in adults, 81.2 (p=0.03) and 85 (p=0.16), respectively, in children and adolescents, and 83.7 (p=0.002) and 86.2 (p=0.003), respectively, in parents and/or guardians. Conclusion: The postoperative scores in the psychosocial (p=0.001), functional (p=0.001) and general (p<0.001) domains had increased in all the patients, demonstrating an improvement in the quality of life following strabismus correction surgery.

https://doi.org/10.5935/0004-2749.2024-0118

Milk Price Variation on the Economic Performance of Dairy Farms in Minas Gerais
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Bassotto, Leandro Carvalho

; Lima, André Luis Ribeiro

; Lopes, Marcos Aurélio

; Lima Netto, Expedito Pereira

BBR. Brazilian Business Review

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2025, Volume 22 elocation e20231454

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo A volatilidade do preço do leite está entre os diversos tipos de risco aos quais as propriedades leiteiras estão expostas, pois se destaca pelo impacto significativo no desempenho econômico desses negócios. Objetivou-se investigar como as variações do preço do leite influenciam o desempenho econômico, bem como sugerir dois indicadores para análises dos riscos em propriedades leiteiras. Utilizou-se a Simulação de Monte Carlo para realizar 10.000 simulações de preços possíveis do leite em 485 propriedades leiteiras localizadas no estado de Minas Gerais. As propriedades com os menores custos de produção foram as que apresentaram as maiores tolerâncias às variações do preço do leite. Aquelas que apresentaram maior eficiência econômica e sofreram os menores riscos decorrentes da variação do preço do leite. Os indicadores aqui sugeridos, denominados Preço de Equilíbrio e Índice de Tolerância do Preço Leite (ITPL), permitiram medir a capacidade dessas propriedades em suportar a redução do preço do leite.

Abstract Milk price volatility is among the several risk types livestock farms are exposed to, since it stands out for its significant impact on these businesses’ economic performance. The aims of the present research are to investigate how product price (milk) variations influence economic performance, as well as suggest an indicator to analyze risks posed to livestock farms in Minas Gerais State, Brazil. The Monte Carlo Simulation was applied to carry out 10.000 simulations of possible milk prices in 485 livestock farms in Minas Gerais State, based on variations observed in this state, from 2015 to 2021. Farms accounting for the lowest production costs were the ones presenting the highest tolerance to milk price variations. Thus, farms showing the best efficiency and profitability suffered with the lowest risks posed by milk price variation. The herein suggest indicators, known as Price Balance and Milk Price Tolerance, allowed measuring these farms’ capacity to support milk price reductions.

https://doi.org/10.15728/bbr.2023.1454.en

Do Brazilian Olympic athletes live longer than the general population? A retrospective cohort study
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Soloaga, Aline Ortega

; Cruz, Arthur Duarte Fantesia Costa

; Spreafico, Elen Viviani Pereira

; Spreafico, Marcos Vinícius Pereira

; Reis, Cássio Pinho dos

; Boullosa, Daniel

; Coelho-Ravagnani, Christianne de Faria

Ciência & Saúde Coletiva

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2025, Volume 30 N. 1 elocation e16862023

Abstract: Pt Es En | Text: Pt Es En | PDF: Pt | PDF: Es | PDF: En

https://doi.org/10.1590/1413-81232025301.16862023

Conidiobolomycosis with neurological commitment in sheep in Pará, Brazil
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Barbosa, Camila Cordeiro

; Filho, Carlos Eduardo da Silva Ferreira

; Silveira, Natália da Silva e Silva

; Oliveira, Carlos Magno Chaves

; Ferreira, Tatiane Teles Albernaz

; Silveira, José Alcides Sarmento da

; Duarte, Marcos Dutra

; Costa, Paulo Sérgio Chagas da

; Pereira, Gabriela Oliveira

; Brito, Marilene de Farias

; Barbosa, José Diomedes

Ciência Rural

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2025, Volume 55 N. 2 elocation e20240016

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

ABSTRACT: The study was conducted on a 3-year-old female Santa Inês sheep from a property located in the municipality of Santo Antônio de Tauá, west of Pará. The affected animal had a history of exophthalmos in the left eye, nasal discharge, and breathing difficulty for more than three months. On physical examination, the animal had a low body score, apathy, unilateral facial asymmetry, moderate unilateral left exophthalmos, mixed dyspnea and unilateral profuse serosanguinous nasal discharge. At necropsy, a large nasal mass was observed, predominantly yellowish-white with blackish-red areas, with an irregular, finely granular, moist, and friable surface. The mass invaded from the mucocutaneous junction of the left nostril to the choanae, infiltrated the frontal sinuses, the cribiform plate, and reached the meninges and the frontal portion of the brain. Microscopy of the surface of the nasal epithelium showed severe destruction of the turbinates and epithelia, evidenced by extensive areas of necrosis with a large amount of cellular debris, ulceration, and secondary bacterial infection. In the central nervous system there was pyogranulomatous meningitis with marked vessel congestion, as well as foci of necrosis and granulomatous inflammation. Immunohistochemistry showed intense staining of numerous intralesional hyphae for antibodies against Conidiobolus lamprauges. The diagnosis of granulomatous rhinitis of mycotic origin associated with the Conidiobolus lamprauges was based on epidemiological, clinical-pathological, and immunohistochemical data.

RESUMO: O estudo foi realizado em um ovino, fêmea, de três anos de idade, da raça santa inês, procedente de uma propriedade localizada do município de Santo Antônio de Tauá, oeste do Pará. O animal acometido tinha histórico de exoftalmia no olho esquerdo, secreção nasal e dificuldade respiratória há mais de três meses. Ao exame físico o animal apresentava baixo escore corporal, apatia, assimetria facial unilateral, moderada exoftalmia unilateral esquerda, dispneia mista e exsudação nasal serossanguinolenta profusa unilateral. À necropsia, foi observada grande massa nasal, predominantemente branco-amarelada com áreas vermelho enegrecidas, de superfície irregular, finamente granular, úmida e friável. A massa invadia desde a junção mucocutânea do nariz esquerdo até as coanas, se infiltrava pelos seios nasais frontais, placa cribiforme e alcançava as meninges e a porção frontal do cérebro. À microscopia da superfície do epitélio nasal notou-se severa destruição dos cornetos e dos epitélios, evidenciada por extensas áreas de necrose com muitos debris celulares, ulceração e infecção bacteriana secundária. No sistema nervoso central (SNC) havia meningite piogranulomatosa com acentuada congestão de vasos, focos de necrose e inflamação granulomatosa. O diagnóstico de rinite granulomatosa de origem micótica associada ao fungo Conidiobolus lamprauges foi baseado nos achados da imuno-histoquímica.

https://doi.org/10.1590/0103-8478cr20240016

Characterisation of the lignocellulosic properties of pruning waste from tree species with the potential for furniture production in Acaraú, Ceará
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Araujo, José Dionis Matos

; Sousa Filho, Men de Sá Moreira de

; Matos, Adriano Lincoln Albuquerque

; Sousa, João Alencar de

; Marques, Francisco Pereira

; Santos, Alisson Moura

; Bezerra, Antonio Marcos Esmeraldo

Revista Ciência Agronômica

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2025, Volume 56 elocation e202192212

Abstract: En | Text: En | PDF: En

ABSTRACT The aim of this study was to characterise the lignocellulosic fractions of pruning waste from tree species showing potential for furniture production in Acaraú, Ceará. The experiment was conducted in a completely randomised, split-plot design, with the plots corresponding to two water regimes (irrigated for one year and irrigated for three years) and the sub-plots to eight tree species, with three replications. The chemical attributes were determined after seven years. Except for the insoluble lignin content, there was a significant effect from the different species in terms of the chemical properties of the wood. The results for the lignocellulosic fractions show the possibility of developing technological ways of adding value to these waste products, especially considering their lignin content. The different species also showed potential for use in producing cellulose pulp, with the exception of Handroanthus impetiginosus due to its high ash content. The results of this study offer new perspectives for future research into the use of forestry waste.

https://doi.org/10.5935/1806-6690.20250012

Comparison of safety and effectiveness of micropulse transscleral cyclophotocoagulation and “slow cook” diode laser transscleral cyclophotocoagulation in patients with refractory open-angle glaucoma
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Russ, Heloisa Helena Abil

; Seixas, Regina Cele Silveira

; Maestrini, Heloísa Andrade

; Balbino, Marcos

; Fernandes, Thatiana Almeida Pereira

; Lima, Núbia Vanessa dos Anjos

; Lopes, Nara Lídia Vieira

; Rodrigues Neto, Taurino dos Santos

Arquivos Brasileiros de Oftalmologia

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2025, Volume 88 N. 1 elocation e2023-0103

Abstract: En | Text: En | PDF: En

ABSTRACT Purpose: This study aimed to compare the safety and effectiveness of intraocular pressure reduction between micropulse transscleral cyclophotocoagulation and “slow cook” transscleral cyclophotocoagulation in patients with refractory primary open-angle glaucoma. Methods: We included patients with primary open angle glaucoma with at least 12 months of follow-up. We collected and analyzed data on the preoperative characteristics and postoperative outcomes. The primary outcomes were a reduction of ≥20% of the baseline value (criterion A) and/or intraocular pressure between 6 and 21 mmHg (criterion B). Results: We included 128 eyes with primary open-angle glaucoma. The preoperative mean intraocular pressure was 25.53 ± 6.40 and 35.02 ± 12.57 mmHg in the micropulse- and “slow cook” transscleral cyclophotocoagulation groups, respectively (p<0.001). The mean intraocular pressure was reduced significantly to 14.33 ± 3.40 and 15.37 ± 5.85 mmHg in the micropulse- and “slow cook” transscleral cyclophotocoagulation groups at the last follow-up, respectively (p=0.110). The mean intraocular pressure reduction at 12 months was 11.20 ± 11.46 and 19.65 ± 13.22 mmHg in the micropulse- and “slow cook” transscleral cyclophotocoagulation groups, respectively (p<0.001). The median preoperative logMAR visual acuity was 0.52 ± 0.69 and 1.75 ± 1.04 in the micropulse- and “slow cook” transscleral cyclophotocoagulation groups, respectively (p<0.001). The mean visual acuity variation was −0.10 ± 0.35 and −0.074 ± 0.16 in the micropulse- and “slow cook” transscleral cyclophotocoagulation, respectively (p=0.510). Preoperatively, the mean eye drops were 3.44 ± 1.38 and 2.89 ± 0.68 drugs in the micropulse- and “slow cook” transscleral cyclophotocoagulation groups, respectively (p=0.017), but those were 2.06 ± 1.42 and 1.02 ± 1.46 at the end of the study in the “slow cook” and micropulse transscleral cyclophotocoagulation groups, respectively (p<0.001). The success of criterion A was not significant between both groups. Compared with 11 eyes (17.74%) in the “slow cook” transscleral cyclophotocoagulation group, 19 eyes (28.78%) in the micropulse transscleral cyclophotocoagulation group showed complete success (p=0.171). For criterion B, 28 (42.42%) and 2 eyes (3.22%) showed complete success after micropulse- and “slow cook” transscleral cyclophotocoagulation, respectively (p<0.001). Conclusion: Both techniques reduced intraocular pressure effectively.

https://doi.org/10.5935/0004-2749.2023-0103

10.

Relationships and Modeling of Cerrado Grassland Fuel in Jalapão, Tocantins state, Brazil
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Moreira Santos, Micael

; Batista, Antonio Carlos

; Rezende, Eduardo Henrique

; Pereira da Silva, Allan Deyvid

; Biondi Batista, Daniela

; Rodrigues dos Santos, Gil

; Giongo, Marcos

Colombia Forestal

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dec 2024, Volume 27 N. 2 elocation e20277

Abstract: Es En | Text: Es En | PDF: Es | PDF: En

Resumen El objetivo de este estudio fue comprender las relaciones entre las diferentes variables de combustible destructivas (pasto y carga de combustible de 1-h) y no destructivas (altura del pasto, altura de la hojarasca, número de especies y número de individuos), en aras de desarrollar modelos para estimar la carga de combustible y la humedad y analizar el consumo de combustible. Este estudio se llevó a cabo en un área protegida ubicada en el bioma Cerrado, en la región de Jalapão, estado de Tocantins, Brasil. Se muestrearon las características no destructivas de la vegetación para determinar las cargas de combustible vivo y muerto en diferentes clases de retardo. Se obtuvieron ecuaciones para estimar estas cargas, con valores de R²aj que varían entre 0.12 y 0.73. Se pudo observar la influencia considerable de la carga de combustible de pasto muerto en el modelado, la cual se considera el principal factor determinante para un mayor consumo de vegetación por el fuego.

Abstract The aim of this study was to understand the relationships between different destructive (grass and 1-h fuel load) and non-destructive fuel variables (grass height, litter height, number of species, and number of individuals), in order to develop models for estimating fuel load and moisture and analyzing fuel consumption. This study was carried out in a protected area located in the Cerrado biome, in the Jalapão region, Tocantins state, Brazil. The non-destructive characteristics of the vegetation were sampled to determine the live and dead fuel loads in different time-lag classes. Equations were obtained to estimate these loads, with values of R²aj, varying from 0.12 to 0.73. The considerable influence of dead grass fuel load on modeling could be observed, which is regarded as the main determining factor for a greater consumption of vegetation by fire.

https://doi.org/10.14483/2256201x.20277

11.

Fenofibrate attenuates renal lipotoxicity in uninephrectomized mice with high-fat diet-induced obesity
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Castro, Barbara Bruna Abreu

; Reno, Petrus Ferreira

; Pereira, Bianca Fatima

; Arriel, Kaique

; Bonato, Fabiana Bastos

; Colugnati, Fernando Antonio Basile

; Cenedeze, Marcos Antonio

; Saraiva-Camara, Niels Olsen

; Sanders-Pinheiro, Helady

Brazilian Journal of Nephrology

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dec 2024, Volume 46 N. 4 elocation e20230148

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

Abstract Introduction: The objective of this study was to investigate the role of fenofibrate, a peroxisome proliferator-activated receptor-α agonist, in obesity-induced kidney damage (lipotoxicity) in mice with uninephrectomy. Methods: C57BL/6 mice underwent uninephrectomy and sham surgeries and were fed normocaloric or high-fat diets. After 10 weeks, obese mice were administered 0.02% fenofibrate for 10 weeks. Kidney function and morphology were evaluated, as well as levels of inflammatory and fibrotic mediators and lipid metabolism markers. Results: High-fat diet-fed mice developed characteristic obesity and hyperlipidemia, with subsequent renal lipid accumulation and damage, including mesangial expansion, interstitial fibrosis, inflammation, and proteinuria. These changes were greater in obese uninephrectomy mice than in obese sham mice. Fenofibrate treatment prevented hyperlipidemia and glomerular lesions, lowered lipid accumulation, ameliorated renal dysfunction, and attenuated inflammation and renal fibrosis. Furthermore, fenofibrate treatment downregulated renal tissue expression of plasminogen activator inhibitor-1, monocyte chemoattractant protein-1, and local expression of fibroblast growth factor-21. Conclusion: Peroxisome proliferator-activated receptor-α activation by fenofibrate, with subsequent lipolysis, attenuated glomerular and tubulointerstitial lesions induced by renal lipotoxicity, thus protecting the kidneys of uninephrectomy mice from obesity-induced lesions. The study findings suggest a pathway in the pharmacological action of fenofibrate, providing insight into the mechanisms involved in kidney damage caused by obesity in kidney donors.

Resumo Introdução: O objetivo deste estudo foi investigar o papel do fenofibrato, um agonista do receptor ativado por proliferadores de peroxissoma-α, na lesão renal induzida por obesidade (lipotoxicidade) em camundongos submetidos à uninefrectomia. Métodos: Camundongos C57BL/6 foram submetidos a uninefrectomia e cirurgias simuladas (sham) e alimentados com dietas normocalóricas ou rica em gordura. Após 10 semanas, os camundongos obesos receberam fenofibrato a 0,02% por 10 semanas. Avaliamos função e morfologia renal, bem como níveis de mediadores inflamatórios e fibróticos e marcadores do metabolismo lipídico. Resultados: Camundongos alimentados com dieta rica em gordura desenvolveram obesidade e hiperlipidemia características, com subsequente acúmulo de lipídios e danos renais, incluindo expansão mesangial, fibrose intersticial, inflamação e proteinúria. Essas alterações foram maiores em camundongos obesos uninefrectomizados do que em camundongos obesos sham. O tratamento com fenofibrato preveniu hiperlipidemia e lesões glomerulares, reduziu o acúmulo de lipídios, melhorou a disfunção renal e atenuou a inflamação e fibrose renal. Além disso, o tratamento com fenofibrato reduziu a expressão no tecido renal do inibidor do ativador do plasminogênio-1, da proteína quimiotática de monócitos-1 e a expressão local do fator de crescimento de fibroblastos-21. Conclusão: A ativação do receptor ativado por proliferadores de peroxissoma-α pelo fenofibrato, com subsequente lipólise, atenuou lesões glomerulares e tubulointersticiais induzidas por lipotoxicidade renal, protegendo, assim, os rins de camundongos uninefrectomizados contra lesões induzidas por obesidade. Os achados do estudo sugerem uma via na ação farmacológica do fenofibrato, fornecendo insights sobre os mecanismos envolvidos no dano renal causado pela obesidade em doadores renais.

https://doi.org/10.1590/2175-8239-jbn-2023-0148en

12.

Exploring the Networks of Relationships Between the 5Cs of Positive Youth Development Through Sport
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Pereira da Silva, Maynara Priscila

; Morais Peixoto, Evandro

; Pereira Palma, Bartira

; Abaide Balbinotti, Marcos Alencar

Acta Colombiana de Psicología

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jun 2024, Volume 27 N. 1 Pages 1 -

Abstract: Es En | Text: Es En | PDF: Es | PDF: En

Resumen El modelo teórico de las 5C (carácter, confianza, competencia, conexión y cariño) es una teoría prometedora para evaluar el desarrollo positivo de los jóvenes (DP]) a través del deporte. Dada la escasez de estudios que evalúen esta interrelación en el contexto brasileño, el objetivo del presente estudio fue explorar las redes de relación de las 5C que se constituyen. La muestra estuvo compuesta por 308 deportistas de entre 14 y 24 años (M=18, 5±2.35, 54.9% mujeres), que respondieron a una batería de medidas de las 5C en el deporte. Se empleó el análisis de red, produciendo seis grupos de ítems. Los resultados del gráfico de red sugirieron que los ítems carácter (2: Líder en el grupo; 5: Soy mejor que otros) y competencia (32: habilidad para ser un líder) son nodos centrales, mientras que las medidas de centralidad identificaron la conexión entrenador-atleta (42: Con mi entrenador, estoy dispuesto a dar lo mejor de mí; 43: Con mi entrenador, adopto una postura amistosa) como de mayor impacto que los clústeres. Los resultados corroboraron la fundamentación teórica, que destaca el papel de la relación entrenador-atleta en el DP] a través del deporte. La aplicación de estas prácticas se presenta en este artículo.

Abstract The theoretical 5Cs model (character, confidence, competence, connection and caring) is a promising theory for evaluating Positive Youth Development (PYD) through sport. Given the scarcity of studies evaluating the interrelationship between the 5Cs of PYD through sport in the Brazilian context, the aim of the present study was to explore the 5C relationship networks. The sample comprised 308 athletes aged between 14 and 24 (M=18, 5±2.35, 54.9% females), who responded to a battery of 5Cs measures in sport. Network analysis was employed, producing six clusters of items. The network graph results suggested that the items Character (2 - leader in the group; 5 - I am better than other) and Competence (32 - ability to be a leader) are central nodes, while the measures of centrality identified the coach-athlete Connection (42 - with my coach, I am ready to do my best; 43 - with my coach, I adopt a friendly stance) as having greater impact than the clusters. The results corroborated the theoretical grounding, which stresses the role of the coach-athlete relationship in PYD through sport. The practical application of these practices is presented here.

https://doi.org/10.14718/acp.2024.27.1.1.5

13.

CRIANÇA NASCIDA POR TÉCNICAS ARTIFICIAIS COM USO DE MATERIAL GENÉTICO ERRADO: OS DIREITOS DE PERSONALIDADE EM QUESTÃO
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Barba, Stela Marcos de Almeida Neves

; Santos Neto, Manoel Pereira dos

; Mota, Shirlei Castro Menezes

Revista Internacional CONSINTER de Direito - Publicação Oficial do Conselho Internacional de Estudos Contemporâneos em Pós-Graduação

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jun 2024, N. 18 Pages 931 - 946

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Caso recente na Argentina, onde uma criança foi gerada por meio de Procriação Medicamente Assistida e não era filha biológica do casal, reabriu as discussões sobre possíveis erros envolvendo técnicas reprodutivas. Neste artigo, feito a partir de revisão bibliográfica e documental, para além da responsabilidade dos centros que realizam o procedimento e dos profissionais envolvidos, tratamos de algo mais delicado: os direitos de quem nasce por “descuido”, tendo a paternidade desconhecida ou questionada ou até mesmo rejeitada, após a vida ter sido gerada de modo não convencional. Os avanços tecnológicos na área da reprodução humana são inegáveis e, de modo geral, contemplam casais impedidos de ter filhos biológicos sem o uso de tais técnicas, como se verifica em Portugal e no Brasil. Entretanto, vida e ética devem estar atreladas para que os direitos de todos sejam respeitados. E, mais especificamente, para que a pessoa não tenha sua vida violada ao nascer, crescendo em meio a disputas judiciais e rejeição de pais que se depararam com resultados de testes de DNA que confirmam a inexistência de esperado vínculo genético. Em tais casos, a paternidade pode ser contestada, inclusive pelos “donos” de óvulos, esperma ou embriões congelados e utilizados por engano, a gerar, por reflexo, a existência de nascituros órfãos, sem pais.

Abstract A recent case in Argentina, where a child was generated through in Medically Assisted Procreation and was not the couple's biological daughter, reopened discussions about possible errors involving reproductive techniques. In this article, based on a bibliographical and documentary review, in addition to the responsibility of the centers that perform the procedure and the professionals involved, we deal with something more delicate: the rights of those who are born by “carelessness”, whose paternity is unknown or questioned or even rejected, after life has been generated in an unconventional way. Technological advances in human reproduction are undeniable and, in general, include couples prevented from having biological children without the use of such techniques, as is the case in Portugal and Brazil. However, life and ethics must be linked so that everyone's rights are respected. And, more specifically, so that the person does not have their life violated at birth, growing up amid legal disputes and rejection of parents who are faced with DNA test results that confirm the absence of the expected genetic bond. In such cases, paternity can be disputed, even by the “owners” of eggs, sperm or embryos frozen and used by mistake, to generate, by reflex, the existence of orphan newborn children, without parents.

https://doi.org/10.19135/revista.consinter.00018.43

14.

Odonatofauna in a Brazilian Cerrado area, featuring the rediscovery of two species
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Dias De Oliveira, Tomás Matheus

; Fôlha Ferreira, Eike Daniel

; Pereira de Gouvêa, Taiguara

; Silva Vilela, Diogo

; de Castro Jacques, Gabriel

; Magalhães de Souza, Marcos

Revista chilena de entomología

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jun 2024, Volume 50 N. 2 Pages 171 - 192

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

Abstract The Cerrado harbors rich biodiversity and yet faces various anthropogenic pressures, an alarming situation that justifies fauna inventory studies, particularly insects, often overlooked in such endeavors. Additionally, many locations within the Cerrado lack information about the odonatofauna, including Conservation Units (CUs), considered the main tools for biodiversity conservation in Brazil. The objective of our study is to report the Odonata community occurring in the Minas Gerais portion of the Parque Nacional Grande Sertão Veredas (PNGSV), the conservation status of species, taxonomic information for some taxa, and compare the Odonata community along wet and dry seasons. The study was conducted from September 2022 to April 2023, with a total of 576 hours of sampling. We collected 601 specimens from 83 species, highlighting two new species (one recently described and other to be described elsewhere), eight new records for the state, and the rediscovery of the species Progomphus geijskesi Needham, 1944, collected for the first time in Brazil since 1918, and Argia botacudo Calvert, 1909, previously known only from the type material. The significant richness sampled, new taxa, new records, and the presence of species at some risk of extinction reinforce the Cerrado's relevance as a global hotspot. It also underscores the importance of CUs as a tool to ensure the protection of Odonata communities in Brazil and highlights the need to strengthen public policies to guarantee investments and foster future financial resources for the protection of Brazilian biota, especially for conducting more inventory studies in the Cerrado.

Resumen El Cerrado alberga una rica biodiversidad y aún enfrenta diversas presiones antropogénicas, una situación alarmante que justifica estudios de inventario de fauna, especialmente de insectos, a menudo pasados por alto en tales esfuerzos. Además, muchos lugares dentro del Cerrado carecen de información sobre la odonatofauna, incluídas las Unidades de Conservación (UC), consideradas las principales herramientas para la conservación de la biodiversidad en Brasil. El objetivo de nuestro estudio es informar sobre la comunidad de odonatos que se encuentra en la porción de Minas Gerais del Parque Nacional Grande Sertão Veredas (PNGSV), el estado de conservación de las especies, información taxonómica para algunos taxones y comparar la comunidad de odonatos durante las estaciones húmeda y seca. El estudio se realizó de septiembre de 2022 a abril de 2023, con un total de 576 horas de muestreo. Recopilamos 601 ejemplares de 83 especies, destacando dos nuevas especies (una recientemente descrita y otra por describirse en otro lugar), ocho nuevos registros para el estado y el redescubrimiento de las especies Progomphus geijskesi Needham, 1944, recolectada por primera vez en Brasil desde 1918, y Argia botacudo Calvert, 1909, conocida anteriormente solo por el material tipo. La riqueza significativa muestreada, los nuevos taxones, los nuevos registros y la presencia de especies en riesgo de extinción refuerzan la relevancia del Cerrado como un hotspot global. También subraya la importancia de las UC como herramienta para garantizar la protección de las comunidades de odonatos en Brasil y destaca la necesidad de fortalecer las políticas públicas para garantizar inversiones y fomentar futuros recursos financieros para la protección de la biota brasileña, especialmente para llevar a cabo más estudios de inventario en el Cerrado.

https://doi.org/10.35249/rche.50.2.24.07

15.

Demandas clínicas e intervenções de enfermagem em consultas gerontológicas: Revisão integrativa
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Muniz, Vinícius de Oliveira

; Leal, Marcos Vinícius Pereira

; Santo, Fátima Helena do Espírito

; Pedreira, Larissa Chaves

; Sousa, Anderson Jácome de

Enfermería Actual de Costa Rica

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jun 2024, N. 46 elocation 58546

Abstract: En Pt Es | Text: En Pt Es | PDF: En | PDF: Pt | PDF: Es

Abstract Introduction: The creation of guidelines that unify the prevalent clinical demands from gerontological nursing consultations and their corresponding interventions are necessary due to the heterogeneity of emerging pathologies in the aging process that will require nursing care. Objective: To identify clinical demands in gerontological nursing consultations and the interventions implemented by nurses. Method: An integrative review of original research published from 2018 and 2022, in English, Spanish, and Portuguese, in Scopus, MEDLINE/PubMed, BIREME/lilacs/BDENF/IBECS/VHL, SciELO, and Google Scholar databases, using the DeCS/MESH descriptors: "Elderly", "Nursing in the Office", "Geriatric Nursing", and "Geriatrics". The Rating System for the Hierarchy of Evidence for Intervention was used to determine the level of evidence of the final sample. Editorials, review studies, and duplicate articles were excluded. The data were analyzed by analytical and interpretative reading, guided by a checklist. Results: Eight articles were selected that showed clinical demands such as deficits in self-care for bathing, self-negligence, fatigue, risk of damaged skin integrity, hopelessness, sadness, and depression. Interventions were related to encouraging self-care, medication optimization, encouragement of exercise, skin care, counseling, music therapy, and psychosocial rehabilitation. Conclusion: There are many different clinical demands in gerontological nursing consultations, especially associated with the domain of activity/rest. These include interventions to treat and prevent diseases, and actions aimed at health promotion, in most cases associated with the behavioral domain.

Resumen Introdução: A criação de guias que unificam as demandas clínicas prevalentes em consultas de enfermagem gerontológica e, das suas respectivas intervenções, se faz presente, devido a heterogeneidade das patologias emergentes no processo de envelhecimento, que irão precisar de cuidados. Objetivo: Identificar as demandas clínicas em consultas de enfermagem gerontológica e, as intervenções implementadas pelos(as) enfermeiros(as). Método: Revisão integrativa de pesquisas originais, publicadas entre 2018 e 2022, em inglês, espanhol e português, disponíveis nas bases de dados Scopus, MEDLINE/PubMed, BIREME/LILACS/BDENF/IBECS/BVS, SciELO e Google Scholar, pelos descritores DeCS/MESH: “Idoso”; “Enfermagem no Consultório”; “Enfermagem Geriátrica” e “Geriatria”. O Rating System for the Hierarchy of Evidence for Intervention foi usado para determinar o nível de evidência da amostra final. Foram excluídos editoriais, estudos de revisão e artigos duplicados. A análise dos dados se deu pela leitura analítica e interpretativa, guiadas por um checklist. Resultados: Oito artigos foram selecionados e trouxeram demandas clínica tais como: o déficit no autocuidado para banho; autonegligência; fadiga; risco de integridade da pele prejudicada; desesperança; tristeza e depressão. As intervenções se relacionaram ao incentivo ao autocuidado; otimização dos medicamentos; estímulo a atividade física; cuidados com a pele; aconselhamento; musicoterapia e reabilitação psicossocial. Conclusão: Demandas clínicas atendidas nas consultas de enfermagem gerontológica possuem grande variação, com prevalência no domínio atividade/repouso, tais como intervenções voltadas para o tratamento e prevenção de doenças e ações visando a promoção da saúde, tendo o domínio comportamental mais expressivo.

Resumen Introducción: La creación de guías que unifiquen las demandas clínicas prevalentes en las consultas de enfermería gerontológica y sus respectivas intervenciones es necesaria, debido a la heterogeneidad de patologías emergentes en el proceso de envejecimiento que requerirán cuidados. Objetivo: Identificar las demandas clínicas en las consultas de enfermería gerontológica y las intervenciones implementadas por el personal de enfermería. Método: Revisión integrativa de investigaciones originales, publicadas entre 2018 y 2022, en inglés, español y portugués, en las bases de datos Scopus, MEDLINE/PubMed, BIREME/LILACS/BDENF/IBECS/BVS, SciELO y Google Scholar. Se utilizaron los descriptores DeCS/MESH: “Idoso”; “Enfermagem no Consultório”; “Enfermagem Geriátrica” e “Geriatria”. Para determinar el nivel de evidencia de la muestra final, se usó el Rating System for the Hierarchy of Evidence for Intervention. Además, se excluyeron los editoriales, los estudios de revisión y los artículos duplicados. Los datos se analizaron mediante lectura analítica e interpretativa, guiada por una lista de verificación. Resultados: Se seleccionaron ocho artículos que aportaron demandas clínicas como déficit en el autocuidado para el baño, autodescuido, fatiga, riesgo integridad de la piel perjudicada; desesperanza, tristeza y depresión. Las intervenciones estaban orientadas al fomento del autocuidado, la optimización de la medicación, el fomento de la actividad física, el cuidado de la piel, el asesoramiento, la musicoterapia y la rehabilitación psicosocial. Conclusión: Las demandas clínicas atendidas en las consultas de enfermería gerontológica son muy variadas, con predominio en el dominio actividad/reposo, como intervenciones dirigidas al tratamiento y prevención de enfermedades y acciones dirigidas a la promoción de la salud, siendo más expresivo el dominio conductual.

https://doi.org/10.15517/enferm.actual.cr.i46.52647

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