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Abstract This article discusses questions concerning the future of humanity in the face of threats to the health of populations, whose impact has been exacerbated in the course of inequalities in all parts of the world, pari passu with global development in the hegemonized model since last century. The COVID-19 pandemic is a good example that illustrates this dissonance between development and inequalities. Questions were formulated to be debated about the construction of the future of world society, based on the understanding of the evolutionary character of life on the planet vis-à-vis the evils that affect large contingents of the population and represent powerful risks for this evolutionary process. These questions call attention to the discussion around social participation in the definition and control of public policies, as opposed to the hegemony of private interests in the formulation and execution of these policies, both in the scenarios of each country and in the international context. populations century COVID19 COVID 19 COVID-1 society visàvis vis à process policies context COVID1 1 COVID-

Resumo O artigo discute questões sobre o futuro da humanidade ante as ameaças que rondam a saúde das populações, cujo impacto vem se exacerbando no curso das desigualdades em todas as partes do mundo, pari passu o desenvolvimento global no modelo hegemonizado a partir do século passado. A pandemia de COVID-19 foi tomada como um caso que bem ilustra essa dessintonia entre desenvolvimento e desigualdades. Formulam-se perguntas a serem postas em debate sobre a construção do futuro da sociedade mundial, com base na acepção sobre o caráter evolucional da vida no planeta vis-à-vis os males que acometem grandes contingentes populacionais e representam poderosos riscos para esse processo evolutivo. São indagações que apontam para a discussão em torno da participação social na definição e no controle das políticas públicas, em contrapartida à hegemonia dos interesses privados na formulação e execução dessas políticas, tanto nos cenários de cada país como no contexto internacional. populações mundo passado COVID19 COVID 19 COVID-1 Formulamse Formulam mundial visàvis vis evolutivo públicas internacional COVID1 1 COVID-

https://doi.org/10.1590/1413-81232024296.07992023

Pestes, desenvolvimento e desigualdades
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Santana, José Francisco Nogueira Paranaguá de

; Silva, José Agenor Alvares da

; Penna, Gerson Oliveira

; Morais, Rafael Santos Gonçalves de Assis

; Nogueira, Roberto Passos

; Lopes, Cecília de Almeida

; Carmo, Eduardo Hage

; Amorim, Manoel de Araújo

; Campos, Roberta de Freitas

Ciência & Saúde Coletiva

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jun 2024, Volume 29 N. 6 elocation e07992023

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

https://doi.org/10.1590/1413-81232024296.07992023

ARHGAP6 transcript levels are associated with molecular risk and impact survival outcomes in acute myeloid leukemia ARHGAP
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Silva, Jean Carlos Lipreri da

; Coelho-Silva, Juan Luiz

; Vicari, Hugo Passos

; Lima, Keli

; Rego, Eduardo Magalhães

; Traina, Fabiola

; Machado-Neto, João Agostinho

Hematology, Transfusion and Cell Therapy

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mar 2024, Volume 46 N. 1 Pages 101 - 105

Abstract: En | Text: En | PDF: En

https://doi.org/10.1016/j.htct.2023.06.004

Diretrizes Brasileiras de Medidas da Pressão Arterial Dentro e Fora do Consultório – 2023 202 20 2
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Feitosa, Audes Diogenes de Magalhães

; Barroso, Weimar Kunz Sebba

; Mion Junior, Decio

; Nobre, Fernando

; Mota-Gomes, Marco Antonio

; Jardim, Paulo Cesar Brandão Veiga

; Amodeo, Celso

; Oliveira, Adriana Camargo

; Alessi, Alexandre

; Sousa, Ana Luiza Lima

; Brandão, Andréa Araujo

; Pio-Abreu, Andrea

; Sposito, Andrei C.

; Pierin, Angela Maria Geraldo

; Paiva, Annelise Machado Gomes de

; Spinelli, Antonio Carlos de Souza

; Machado, Carlos Alberto

; Poli-de-Figueiredo, Carlos Eduardo

; Rodrigues, Cibele Isaac Saad

; Forjaz, Claudia Lucia de Moraes

; Sampaio, Diogo Pereira Santos

; Barbosa, Eduardo Costa Duarte

; Freitas, Elizabete Viana de

; Cestario, Elizabeth do Espirito Santo

; Muxfeldt, Elizabeth Silaid

; Lima Júnior, Emilton

; Campana, Erika Maria Gonçalves

; Feitosa, Fabiana Gomes Aragão Magalhães

; Consolim-Colombo, Fernanda Marciano

; Almeida, Fernando Antônio de

; Silva, Giovanio Vieira da

; Moreno Júnior, Heitor

; Finimundi, Helius Carlos

; Guimarães, Isabel Cristina Britto

; Gemelli, João Roberto

; Barreto-Filho, José Augusto Soares

; Vilela-Martin, José Fernando

; Ribeiro, José Marcio

; Yugar-Toledo, Juan Carlos

; Magalhães, Lucélia Batista Neves Cunha

; Drager, Luciano F.

; Bortolotto, Luiz Aparecido

; Alves, Marco Antonio de Melo

; Malachias, Marcus Vinícius Bolívar

; Neves, Mario Fritsch Toros

; Santos, Mayara Cedrim

; Dinamarco, Nelson

; Moreira Filho, Osni

; Passarelli Júnior, Oswaldo

; Vitorino, Priscila Valverde de Oliveira

; Miranda, Roberto Dischinger

; Bezerra, Rodrigo

; Pedrosa, Rodrigo Pinto

; Paula, Rogerio Baumgratz de

; Okawa, Rogério Toshiro Passos

; Póvoa, Rui Manuel dos Santos

; Fuchs, Sandra C.

; Lima, Sandro Gonçalves de

; Inuzuka, Sayuri

; Ferreira-Filho, Sebastião Rodrigues

; Fillho, Silvio Hock de Paffer

; Jardim, Thiago de Souza Veiga

; Guimarães Neto, Vanildo da Silva

; Koch, Vera Hermina Kalika

; Gusmão, Waléria Dantas Pereira

; Oigman, Wille

; Nadruz Junior, Wilson

Arquivos Brasileiros de Cardiologia

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2024, Volume 121 N. 4 elocation e20240113

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

https://doi.org/10.36660/abc.20240113

GJB2 c.35del variant up-regulates GJA1 gene expression and affects differentiation of human stem cells GJB c35del cdel c 35del del upregulates up regulates GJA
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Batissoco, Ana Carla

; Cruz, Dayane Bernardino

; Alegria, Thiago Geronimo Pires

; Kobayashi, Gerson

; Oiticica, Jeanne

; Soares Netto, Luis Eduardo

; Passos-Bueno, Maria Rita

; Haddad, Luciana Amaral

; Mingroni Netto, Regina Célia

Genetics and Molecular Biology

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2024, Volume 47 N. 2 elocation e20230170

Abstract: En | Text: En | PDF: En

Abstract Pathogenic DNA alterations in GJB2 are present in nearly half of non-syndromic hearing loss cases with autosomal recessive inheritance. The most frequent variant in GJB2 causing non-syndromic hearing loss is the frameshifting c.35del. GJB2 encodes Cx26, a protein of the connexin family that assembles hemichannels and gap junctions. The expression of paralogous proteins is believed to compensate for the loss of function of specific connexins. As Cx26 has been involved in cell differentiation in distinct tissues, we employed stem cells derived from human exfoliated deciduous teeth (SHEDs), homozygous for the c.35del variant, to assess GJB2 roles in stem cell differentiation and the relationship between its loss of function and the expression of paralogous genes. Primary SHED cultures from patients and control individuals were compared. SHEDs from patients had significantly less GJB2 mRNA and increased amount of GJA1 (Cx43), but not GJB6 (Cx30) or GJB3 (Cx31) mRNA. In addition, they presented higher induced differentiation to adipocytes and osteocytes but lower chondrocyte differentiation. Our results suggest that GJA1 increased expression may be involved in functional compensation for GJB2 loss of function in human stem cells, and it may explain changes in differentiation properties observed in SHEDs with and without the c.35del variant. GJB nonsyndromic non syndromic inheritance c35del cdel c 35del del Cx junctions connexins Cx2 tissues SHEDs, , (SHEDs) genes compared GJA Cx43, Cx43 (Cx43) Cx30 (Cx30 Cx31 (Cx31 addition (SHEDs Cx4 (Cx43 Cx3 (Cx3 (Cx4 (Cx

https://doi.org/10.1590/1678-4685-gmb-2023-0170

Early rootstock selection under ‘tahiti’ acid lime crown in Capitão Poço, Pará State, Brazil ‘tahiti tahiti Poço State
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Gurgel, Fábio de Lima

; Mariguele, Keny Henrique

; Yokomizo, Gilberto Ken Iti

; Andrade Neto, Romeu de Carvalho

; Girardi, Eduardo Augusto

; Passos, Orlando Sampaio

; Soares Filho, Walter dos Santos

Acta Scientiarum. Agronomy

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2024, Volume 46 elocation e63302

Abstract: En | Text: En | PDF: En

ABSTRACT. Citrus represents one of the main fruit crops grown in the world, highlighting the ‘Tahiti’ acid lime tree. The objective was to compare rootstock varieties combined with this scion to identify those with the best agronomic performance and precocity of production, in addition to Phytophthora gummosis resistance. The experiment was carried out in Capitão Poço, northeast region of Pará, and the following seven rootstock genotypes were evaluated: ‘Sunki Tropical’, ‘BRS O S Passos’, ‘BRS Bravo’, ‘BRS Donadio’, ‘Citrandarin Indio’, ‘BRS Matta’, and ‘LVK x LCR-038’. A randomized block experimental design was used, with three replications and 10 plants per plot. The evaluated characteristics were: plant height (m); crown volume (m3); number of ripe fruit per plant; total yield of ripened fruit per plant (kg plant-1); cumulative fruit yield (fruit kg plant-1); and average productive efficiency (fruit kg m-3 of crown). The average productive efficiency was high. For early selection, the best rootstocks in terms of yield, stability and adaptability were Sunki Tropical, BRS O S Passos, and Cintradarin Indio. The fruit number had the greatest direct effect on fruit yield, and crown pruning was directly harmful. Further studies to understand the complex interaction of G x E for BRS Donadio and Sunki Tropical should be carried out. ABSTRACT world ‘Tahiti Tahiti tree production resistance Poço Pará , Tropical’ Passos Passos’ Bravo, Bravo Bravo’ Donadio, Donadio’ Citrandarin Indio, Indio Indio’ Matta, Matta Matta’ LVK LCR038. LCR038 LCR 038 . LCR-038’ used 1 plot m (m) m3 (m3) plant1 plant-1) 3 m- crown. crown) high selection harmful LCR03 03 LCR-038 (m (m3 plant-1 LCR0 0 LCR-03 plant- LCR-0 LCR-

https://doi.org/10.4025/actasciagron.v46i1.63302

The high biodiversity of benthic organisms in a coastal ecosystem revealed by an integrative approach
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Amaral, A. Cecília Z.

; Cunha, Beatriz P.

; Checon, Helio H.

; Godoy, Angélica S. de

; Silva, Camila F. da

; Corte, Guilherme N.

; Nogueira, João M. de M.

; Fukuda, Marcelo V.

; Steiner, Tatiana M.

; Kawauchi, Gisele Y.

; Turra, Alexander

; Denadai, Márcia R.

; Ferreira, Luciane

; Mendonça, Joel B. de

; Tavares, Marcos

; Leite, Fosca P. P.

; Costa, Mariana F. B.

; Siqueira, Silvana G. L.

; Vieira, Leandro M.

; Dias, Gustavo M.

; Teixeira, Joyce A.

; Rocha, Rosana M.

; Gusmão, Luciana C.

; Borges, Michela

; Alitto, Renata

; Machado, Fabrizio M.

; Passos, Flávio D.

; Cunha, Carlo M.

; Simone, Luiz R.L.

; Araujo, Ana Paula G.

; Carbayo, Fernando

; Bahia, Juliana

; Bulnes, Verónica N.

; Castello-Branco, Cristiana

; Hajdu, Eduardo

; Vilas-Boas, Ana Carolina

; Garraffoni, André R. S.

; Schockaert, Ernest

; Fonseca, Gustavo

; Domenico, Maikon Di

; Curini-Galletti, Marco

; Sørensen, Martin V.

; Hochberg, Rick

; Oliveira, Ana Julia F. C. de

; Zampieri, Bruna Del B.

; Chinelatto, Roberta M.

; Migotto, Alvaro E.

Biota Neotropica

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2024, Volume 24 N. 2 elocation e20231583

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

Abstract Increasing habitat modification and species loss demand consistent efforts to describe and understand biodiversity patterns. The BIOTA/FAPESP Program was created in this context and it has been a successful initiative to promote studies on biodiversity and conservation in Brazil. The BIOTA/Araçá is an interdisciplinary project that provided a detailed evaluation of the biodiversity of Araçá Bay, a coastal seascape located on the North coast of the state of São Paulo, Southeast Brazil. The bay encompasses multiple habitats, such as beaches, mangroves, rocky shores, and a tidal flat, and provides important ecosystem services. Unfortunately, the bay is the subject of complex social-environmental conflicts that oppose economic, social, and environmental demands (i.e., the expansion of neighboring harbor activities vs. small-scale artisanal fisheries and protection of biodiversity). The present study presents a survey of the benthic species occurring in the different habitats of Araçá Bay, including data obtained during the BIOTA/Araçá project and previous assessments of the area. The benthic species play an important role in marine environments and studying the diversity of these organisms that live associated with the bottom is indispensable for comprehending the environment’s functioning. The macrofauna, meiofauna, and microorganisms associated with soft and hard bottom were listed, and additional information, such as the habitat and geographical distribution, were provided for each species. The checklist includes 826 species, almost 70% recorded during the BIOTA/Araçá project. The most speciose taxa were the annelids (225 spp.), mollusks (194 spp.), and crustaceans (177 spp.). Seven benthic species are endemic to Araçá Bay, 14 are considered threatened, and seven are economically exploited. Furthermore, the bay is the type locality of many taxa, and 11 new benthic species were described based on specimens sampled during the project. This project shows the importance of Araçá Bay as a unique biologically rich environment and highlights the need for conservation efforts in light of the current threats. patterns BIOTAFAPESP BIOTA FAPESP Brazil BIOTAAraçá Paulo beaches mangroves shores flat services Unfortunately socialenvironmental social economic i.e., ie i e (i.e. vs smallscale small scale biodiversity. . biodiversity) area s functioning macrofauna meiofauna listed information distribution 82 70 225 (22 spp., spp spp. , spp.) 194 (19 177 (17 spp.. 1 threatened exploited Furthermore threats i.e. (i.e 8 7 22 (2 19 (1 17 i.e 2 (

Resumo O aumento da modificação dos habitats e da perda de espécies demanda esforços consistentes para descrever e compreender os padrões de biodiversidade. O programa BIOTA/FAPESP foi criado nesse contexto e é uma iniciativa de sucesso para promover estudos em biodiversidade e conservação no Brasil. O BIOTA/Araçá é um projeto interdisciplinar que promoveu uma avaliação detalhada da biodiversidade da Baía do Araçá, um ecossistema costeiro localizado ao Norte do estado de São Paulo, Sudeste do Brasil. A baía engloba múltiplos habitats, tais como praias, manguezais, costões rochosos, e uma planície de maré, e também fornece importantes serviços ecossistêmicos. Infelizmente, a baía está sujeita à conflitos sócio-ambientais complexos que contrastam demandas econômicas, sociais e ambientais (i.e. a expansão das atividades do porto vizinho vs. a pesca artesanal de pequena escala e a proteção da biodiversidade). O presente estudo apresenta um levantamento das espécies bentônicas que ocorrem nos diferentes habitats da Baía do Araçá, incluindo dados obtidos durante o projeto BIOTA/Araçá e de investigações realizadas anteriormente na área. As espécies bentônicas desempenham um papel importante no ambiente marinho, e estudar a diversidade desses organismos que vivem associados ao fundo é indispensável para compreender o funcionamento do meio ambiente. A macrofauna, meiofauna, e microorganismos associados aos fundos consolidado e inconsolidado foram listados, e informações adicionais foram fornecidas para cada espécie, tais como a distribuição geográfica e nos habitats. O checklist inclui 826 espécies, quase 70% registradas durante o projeto BIOTA/Araçá. Os taxa mais especiosos foram os anelídeos (225 spp.), moluscos (194 spp.), e crustáceos (177 spp.). Entre as espécies bentônicas listadas, sete são endêmicas da Baía do Araçá, 14 são consideradas ameaçadas de extinção, e sete são exploradas economicamente. A baía é a localidade tipo de vários taxa, e 11 novas espécies bentônicas foram descritas com base em espécimes amostrados durante o projeto. Este projeto mostra a importância da Baía do Araçá como um ambiente de riqueza biológica única e demonstra a necessidade de esforços para a sua conservação considerando as atuais ameaças. BIOTAFAPESP BIOTA FAPESP Brasil BIOTAAraçá Paulo praias manguezais rochosos maré ecossistêmicos Infelizmente sócioambientais sócio econômicas i.e. ie i (i.e vs . biodiversidade) área marinho macrofauna meiofauna listados espécie 82 70 225 (22 spp., spp spp. , spp.) 194 (19 177 (17 spp.. listadas 1 extinção economicamente ameaças i.e 8 7 22 (2 19 (1 17 2 (

https://doi.org/10.1590/1676-0611-bn-2023-1583

Feasibility, safety, and adherence of a remote physical and cognitive exercise protocol for older women Feasibility safety
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Peixoto, Cristiane

; Matioli, Maria Niures Pimentel dos Santos

; Takano, Satiko Andrezza Ferreira

; Teixeira, Maurício Silva

; Borges Passos Neto, Carlos Eduardo

; Dozzi Brucki, Sonia Maria

Arquivos de Neuro-Psiquiatria

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2024, Volume 82 N. 4 elocation s00441785690

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

Abstract Background Population aging and the consequences of social distancing after the COVID-19 pandemic make it relevant to investigate the feasibility of remote interventions and their potential effects on averting functional decline. Objective (1) To investigate the feasibility, safety, and adherence of a remote protocol involving physical and cognitive exercises for older women with normal cognition; (2) to examine its effects on cognitive and well-being variables. Methods Twenty-nine women (age ≥ 60 years old) were randomized into experimental group (EG; n= 15) and control group (CG; n= 14). The EG performed a 40-minute session of cognitive and physical exercises, and CG performed a 20-minute stretching session. Both groups performed 20 sessions via videoconference and 20 on YouTube twice a week. The Mini-Mental State Examination, Verbal Fluency Test, Digit Span (direct an inverse order), Geriatric Depression Scale (GDS), and Well-being Index (WHO-5) were applied in pre- and post-interventions by phone. Results Overall adherence was 82.25% in EG and 74.29% in CG. The occurrence of adverse events (mild muscle pain) was 33.3% in EG and 21.4% in CG. The EG improved verbal fluency and attention (p ≤ 0.05); both groups had improved depressive symptoms. Conclusion The present study met the pre-established criteria for feasibility, safety, and adherence to the remote exercise protocol among older women. The results suggest that a combined protocol has more significant potential to improve cognitive function. Both interventions were beneficial in improving the subjective perception of well-being. COVID19 COVID 19 COVID-1 decline 1 (1 safety cognition 2 (2 wellbeing well being variables Twentynine Twenty nine age 6 old (EG n 15 (CG 14. 14 . 14) 40minute minute 40 20minute week MiniMental Mini Mental Examination Test direct order, order , order) GDS, GDS (GDS) Wellbeing Well WHO5 WHO 5 (WHO-5 pre postinterventions post phone 8225 82 25 82.25 7429 74 29 74.29 mild pain 333 33 3 33.3 214 21 4 21.4 p 0.05 005 0 05 0.05) symptoms preestablished established function wellbeing. being. COVID1 COVID- ( (GDS (WHO- 822 8 82.2 742 7 74.2 33. 21. 0.0 00 (WHO 82. 74. 0.

Resumo Antecedentes O envelhecimento populacional e as consequências do isolamento social após a pandemia de COVID-19 tornaram relevante investigar a viabilidade, segurança e aderência de intervenções remotas e potenciais efeitos para prevenir declínios funcionais. Objetivo (1) Investigar a viabilidade, segurança e aderência de um protocolo remoto de exercícios físicos e cognitivos; (2) investigar os possíveis efeitos sobre variáveis de cognição e de bem-estar. Métodos Vinte e nove mulheres foram randomicamente divididas em grupo experimental (GE; n= 15) e grupo controle (GC; n= 14). O GE realizou sessões de 40 minutos de exercícios físicos e cognitivos e o GC, 20 minutos de alongamentos. Totalizaram 20 sessões por videoconferência e 20 pelo YouTube, duas vezes por semana. O Teste de Fluência Verbal, o Teste de Dígitos (ordem direta e inversa), a Escala de Depressão Geriátrica (GDS) e o Índice de Bem-Estar (WHO-5) foram aplicados no pré e pós-intervenção, por telefone e formulário digital. Resultados A aderência geral média foi de 82,25% no GE e 74,29% no GC. A ocorrência de eventos adversos (dores musculares leves) foi de 33,3% no GE e 21,4% no GC. O GE teve melhora em fluência verbal e atenção (p ≤ 0.05) e ambos os grupos tiveram melhora significativa nos sintomas depressivos. Conclusão O presente estudo atendeu aos critérios preestabelecidos para a viabilidade, segurança e aderência do programa oferecido entre idosas. Os resultados sugerem que o protocolo combinado tenha maior potencial de aprimorar funções cognitivas. Ambas as intervenções foram benéficas para a percepção subjetiva de bem-estar. COVID19 COVID 19 COVID-1 viabilidade funcionais 1 (1 2 (2 bemestar. bemestar bem estar. estar bem-estar (GE n 15 GC (GC 14. 14 . 14) 4 alongamentos YouTube semana Verbal ordem inversa, inversa , inversa) GDS (GDS BemEstar Bem Estar WHO5 WHO 5 (WHO-5 pósintervenção, pósintervenção pós intervenção, intervenção pós-intervenção digital 8225 82 25 82,25 7429 74 29 74,29 dores leves 333 33 3 33,3 214 21 21,4 p 0.05 005 0 05 depressivos idosas cognitivas COVID1 COVID- ( (WHO- 822 8 82,2 742 7 74,2 33, 21, 0.0 00 (WHO 82, 74, 0.

https://doi.org/10.1055/s-0044-1785690

Nutritional reference values using the DRIS method and sample size for peach palm production
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Conceição, Mariana Passos da

; Rozane, Danilo Eduardo

; Pereira, Eder Florêncio

; Oliveira, Cibelle Tamiris de

; Lima, Juliana Domingues

; Lima Neto, Antonio João de

Revista Brasileira de Ciência do Solo

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2024, Volume 48 elocation e0230076

Abstract: En | Text: En | PDF: En

ABSTRACT One of the challenges in the peach palm production system is the interpretation of leaf analyses and the adaptation of fertilization recommendations. Tools that enhance fertilizer use efficiency are therefore needed. This study aimed to establish norms for evaluating the nutrient status of peach palms using the Diagnosis and Recommendation Integrated System (DRIS) and to determine the adequate number of palm heart samples necessary for a more accurate assessment of productivity. Production, leaf nutrient content, and soil fertility data were collected from 102 commercial stands of peach palm in the Ribeira Valley, state of São Paulo, Brazil, between 2015 and 2020. Adequate number of individual samples (palm hearts) to be collected per stand for productivity assessment was estimated. DRIS norms were established by dividing the database into high-yield (reference population) and low-yield subpopulations, using average productivity as a criterion. By assuming an acceptable error of 5 to 10 % for the assessment of peach palm productivity, taking into account total palm heart weight and/or the weight of cylinders, respectively, 16 plants per stand should be sampled. DRIS was not sensitive enough to diagnose differences in the probability of positive response to fertilization; however, the P, K, Ca, Mg, S, B, Fe, Cu, Mn and Zn contents were positively correlated with the respective nutrient indices. recommendations needed (DRIS Production content Valley Paulo Brazil 201 2020 hearts estimated highyield high yield reference population lowyield low subpopulations criterion 1 andor or cylinders respectively sampled however P K Ca Mg S B Fe Cu indices 20 202 2

https://doi.org/10.36783/18069657rbcs20230076

10.

[SciELO Preprints] - Brazilian Guidelines for In-office and Out-of-office Blood Pressure Measurement – 2023
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Feitosa, Audes Diógenes de Magalhães Barroso, Weimar Kunz Sebba Mion Júnior, Décio Nobre, Fernando Mota-Gomes, Marco Antonio Jardim, Paulo Cesar Brandão Veiga Amodeo, Celso Camargo, Adriana Alessi, Alexandre Sousa, Ana Luiza Lima Brandão, Andréa Araujo Pio-Abreu, Andrea Sposito, Andrei Carvalho Pierin, Angela Maria Geraldo Paiva, Annelise Machado Gomes de Spinelli, Antonio Carlos de Souza Machado, Carlos Alberto Poli-de-Figueiredo, Carlos Eduardo Rodrigues, Cibele Isaac Saad Forjaz, Cláudia Lúcia de Moraes Sampaio, Diogo Pereira Santos Barbosa, Eduardo Costa Duarte Freitas, Elizabete Viana de Cestário , Elizabeth do Espírito Santo Muxfeldt, Elizabeth Silaid Lima Júnior, Emilton Campana, Erika Maria Gonçalves Feitosa, Fabiana Gomes Aragão Magalhães Consolim-Colombo, Fernanda Marciano Almeida, Fernando Antônio de Silva, Giovanio Vieira da Moreno Júnior, Heitor Finimundi, Helius Carlos Guimarães, Isabel Cristina Britto Gemelli, João Roberto Barreto Filho, José Augusto Soares Vilela-Martin, José Fernando Ribeiro, José Marcio Yugar-Toledo, Juan Carlos Magalhães, Lucélia Batista Neves Cunha Drager, Luciano Ferreira Bortolotto, Luiz Aparecido Alves, Marco Antonio de Melo Malachias, Marcus Vinícius Bolívar Neves, Mario Fritsch Toros Santos, Mayara Cedrim Dinamarco, Nelson Moreira Filho, Osni Passarelli Júnior, Oswaldo Valverde de Oliveira Vitorino, Priscila Valverde de Oliveira Miranda, Roberto Dischinger Bezerra, Rodrigo Pedrosa, Rodrigo Pinto Paula, Rogério Baumgratz de Okawa, Rogério Toshiro Passos Póvoa, Rui Manuel dos Santos Fuchs, Sandra C. Inuzuka, Sayuri Ferreira-Filho, Sebastião R. Paffer Fillho, Silvio Hock de Jardim, Thiago de Souza Veiga Guimarães Neto, Vanildo da Silva Koch, Vera Hermina Gusmão, Waléria Dantas Pereira Oigman, Wille Nadruz, Wilson

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Publication date: 2023-09-23

Abstract: En Es Pt

Hypertension is one of the primary modifiable risk factors for morbidity and mortality worldwide, being a major risk factor for coronary artery disease, stroke, and kidney failure. Furthermore, it is highly prevalent, affecting more than one-third of the global population. Blood pressure measurement is a MANDATORY procedure in any medical care setting and is carried out by various healthcare professionals. However, it is still commonly performed without the necessary technical care. Since the diagnosis relies on blood pressure measurement, it is clear how important it is to handle the techniques, methods, and equipment used in its execution with care. It should be emphasized that once the diagnosis is made, all short-term, medium-term, and long-term investigations and treatments are based on the results of blood pressure measurement. Therefore, improper techniques and/or equipment can lead to incorrect diagnoses, either underestimating or overestimating values, resulting in inappropriate actions and significant health and economic losses for individuals and nations. Once the correct diagnosis is made, as knowledge of the importance of proper treatment advances, with the adoption of more detailed normal values and careful treatment objectives towards achieving stricter blood pressure goals, the importance of precision in blood pressure measurement is also reinforced. Blood pressure measurement (described below) is usually performed using the traditional method, the so-called casual or office measurement. Over time, alternatives have been added to it, through the use of semi-automatic or automatic devices by the patients themselves, in waiting rooms or outside the office, in their own homes, or in public spaces. A step further was taken with the use of semi-automatic devices equipped with memory that allow sequential measurements outside the office (ABPM; or HBPM) and other automatic devices that allow programmed measurements over longer periods (HBPM). Some aspects of blood pressure measurement can interfere with obtaining reliable results and, consequently, cause harm in decision-making. These include the importance of using average values, the variation in blood pressure during the day, and short-term variability. These aspects have encouraged the performance of a greater number of measurements in various situations, and different guidelines have advocated the use of equipment that promotes these actions. Devices that perform HBPM or ABPM, which, in addition to allowing greater precision, when used together, detect white coat hypertension (WCH), masked hypertension (MH), sleep blood pressure alterations, and resistant hypertension (RHT) (defined in Chapter 2 of this guideline), are gaining more and more importance. Taking these details into account, we must emphasize that information related to diagnosis, classification, and goal setting is still based on office blood pressure measurement, and for this reason, all attention must be given to the proper execution of this procedure.

La hipertensión arterial (HTA) es uno de los principales factores de riesgo modificables para la morbilidad y mortalidad en todo el mundo, siendo uno de los mayores factores de riesgo para la enfermedad de las arterias coronarias, el accidente cerebrovascular (ACV) y la insuficiencia renal. Además, es altamente prevalente y afecta a más de un tercio de la población mundial. La medición de la presión arterial (PA) es un procedimiento OBLIGATORIO en cualquier atención médica o realizado por diferentes profesionales de la salud. Sin embargo, todavía se realiza comúnmente sin los cuidados técnicos necesarios. Dado que el diagnóstico se basa en la medición de la PA, es claro el cuidado que debe haber con las técnicas, los métodos y los equipos utilizados en su realización. Debemos enfatizar que una vez realizado el diagnóstico, todas las investigaciones y tratamientos a corto, mediano y largo plazo se basan en los resultados de la medición de la PA. Por lo tanto, las técnicas y/o equipos inadecuados pueden llevar a diagnósticos incorrectos, subestimando o sobreestimando valores y resultando en conductas inadecuadas y pérdidas significativas para la salud y la economía de las personas y las naciones. Una vez realizado el diagnóstico correcto, a medida que avanza el conocimiento sobre la importancia del tratamiento adecuado, con la adopción de valores de normalidad más detallados y objetivos de tratamiento más cuidadosos hacia metas de PA más estrictas, también se refuerza la importancia de la precisión en la medición de la PA. La medición de la PA (descrita a continuación) generalmente se realiza mediante el método tradicional, la llamada medición casual o de consultorio. Con el tiempo, se han agregado alternativas a través del uso de dispositivos semiautomáticos o automáticos por parte del propio paciente, en salas de espera o fuera del consultorio, en su propia residencia o en espacios públicos. Se dio un paso más con el uso de dispositivos semiautomáticos equipados con memoria que permiten mediciones secuenciales fuera del consultorio (AMPA; o MRPA) y otros automáticos que permiten mediciones programadas durante períodos más largos (MAPA). Algunos aspectos en la medición de la PA pueden interferir en la obtención de resultados confiables y, en consecuencia, causar daños en las decisiones a tomar. Estos incluyen la importancia de usar valores promedio, la variación de la PA durante el día y la variabilidad a corto plazo. Estos aspectos han alentado la realización de un mayor número de mediciones en diversas situaciones, y diferentes pautas han abogado por el uso de equipos que promuevan estas acciones. Los dispositivos que realizan MRPA o MAPA, que además de permitir una mayor precisión, cuando se usan juntos, detectan la hipertensión de bata blanca (HBB), la hipertensión enmascarada (HM), las alteraciones de la PA durante el sueño y la hipertensión resistente (HR) (definida en el Capítulo 2 de esta guía), están ganando cada vez más importancia. Teniendo en cuenta estos detalles, debemos enfatizar que la información relacionada con el diagnóstico, la clasificación y el establecimiento de objetivos todavía se basa en la medición de la presión arterial en el consultorio, y por esta razón, se debe prestar toda la atención a la ejecución adecuada de este procedimiento.

A hipertensão arterial (HA) é um dos principais fatores de risco modificáveis para morbidade e mortalidade em todo o mundo, sendo um dos maiores fatores de risco para doença arterial coronária, acidente vascular cerebral (AVC) e insuficiência renal. Além disso, é altamente prevalente e atinge mais de um terço da população mundial. A medida da PA é procedimento OBRIGATÓRIO em qualquer atendimento médico ou realizado por diferentes profissionais de saúde. Contudo, ainda é comumente realizada sem os cuidados técnicos necessários. Como o diagnóstico se baseia na medida da PA, fica claro o cuidado que deve haver com as técnicas, os métodos e os equipamentos utilizados na sua realização. Deve-se reforçar que, feito o diagnóstico, toda a investigação e os tratamentos de curto, médio e longo prazos são feitos com base nos resultados da medida da PA. Assim, técnicas e/ou equipamentos inadequados podem levar a diagnósticos incorretos, tanto subestimando quanto superestimando valores e levando a condutas inadequadas e grandes prejuízos à saúde e à economia das pessoas e das nações. Uma vez feito o diagnóstico correto, na medida em que avança o conhecimento da importância do tratamento adequado, com a adoção de valores de normalidade mais detalhados e com objetivos de tratamento mais cuidadosos no sentido do alcance de metas de PA mais rigorosas, fica também reforçada a importância da precisão na medida da PA. A medida da PA (descrita a seguir) é habitualmente feita pelo método tradicional, a assim chamada medida casual ou de consultório. Ao longo do tempo, foram agregadas alternativas a ela, mediante o uso de equipamentos semiautomáticos ou automáticos pelo próprio paciente, nas salas de espera ou fora do consultório, em sua própria residência ou em espaços públicos. Um passo adiante foi dado com o uso de equipamentos semiautomáticos providos de memória que permitem medidas sequenciais fora do consultório (AMPA; ou MRPA) e outros automáticos que permitem medidas programadas por períodos mais prolongados (MAPA). Alguns aspectos na medida da PA podem interferir na obtenção de resultados fidedignos e, consequentemente, causar prejuízo nas condutas a serem tomadas. Entre eles, estão: a importância de serem utilizados valores médios, a variação da PA durante o dia e a variabilidade a curto prazo. Esses aspectos têm estimulado a realização de maior número de medidas em diversas situações, e as diferentes diretrizes têm preconizado o uso de equipamentos que favoreçam essas ações. Ganham cada vez mais espaço os equipamentos que realizam MRPA ou MAPA, que, além de permitirem maior precisão, se empregados em conjunto, detectam a HA do avental branco (HAB), HA mascarada (HM), alterações da PA no sono e HA resistente (HAR) (definidos no Capítulo 2 desta diretriz). Resguardados esses detalhes, devemos ressaltar que as informações relacionadas a diagnóstico, classificação e estabelecimento de metas ainda são baseadas na medida da PA de consultório e, por esse motivo, toda a atenção deve ser dada à realização desse procedimento.

https://doi.org/10.1590/SciELOPreprints.7057

11.

Decomposition and release of nutrients from species of tropical green manure
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Mangaravite, José Carlos Soares

; Passos, Renato Ribeiro

; Andrade, Felipe Vaz

; Silva, Victor Maurício da

; Marin, Ericka Broetto

; Mendonça, Eduardo de Sá

Revista Ceres

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jun 2023, Volume 70 N. 3 Pages 114 - 124

Abstract: En | Text: En | PDF: En

ABSTRACT Decomposition processes and mineralization are essential to determine the time to deploy and manage species in consortia or rotations. The aim of this article was study the dynamics of biomass decomposition and release of macronutrients of plant residues of Fabacea. The species used were: jack bean (Canavalia ensiformis), pigeon pea (Cajanus cajan), dwarf mucuna (Mucuna deeringiana) and sunn hemp (Crotalaria juncea). The experiment was conducted in the field in a randomized block design, 4 x 5 factorial, four species of green manure and five times (0, 30, 60, 90, and 120 days). In the results, sunn hemp and pigeon pea had lower decomposition and release of C, N, K, and Mg. All species, K and P showed similar half-lives (t1/2). For N, sunn hemp presented the lowest coefficient of mineralization (k), 0.0040 g g-1 dia-1, associated with highest t1/2 (173.3 days), already, jack bean showed the highest k (0.0122 g g-1 dia-1) associated with the lowest t1/2 (56.8 days). In edaphoclimatic conditions, use of the jack bean and the dwarf mucuna is recommended for supply of nutrients in shorter periods of time for subsequent crops. However, sunn hemp and pigeon pea are recommended for greater persistence of mulch on the soil. rotations Fabacea were Canavalia ensiformis, ensiformis , ensiformis) Cajanus cajan, cajan cajan) Mucuna deeringiana Crotalaria juncea. juncea . juncea) design factorial 0, 0 (0 30 60 90 12 days. days days) results C N Mg halflives half lives t1/2. t12 t t1 2 (t1/2) k, (k) 00040 0040 0.004 g1 1 g- dia1, dia1 dia 1, dia-1 t1/ 173.3 1733 173 3 (173. days, already 0.0122 00122 0122 (0.012 56.8 568 56 8 (56. conditions crops However soil ( 6 9 (t1/2 (k 0004 004 0.00 dia- 173. 17 (173 0.012 0012 012 (0.01 56. (56 (t1/ 000 00 0.0 (17 0.01 001 01 (0.0 (5 (t1 0. (1 (0. (t

https://doi.org/10.1590/0034-737x202370030012

12.

University Pharmacy: from the foundation to the Pandemic times of Covid-19 Pharmacy Covid19 Covid 19 Covid-1 Covid1 1 Covid-
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Ricci-Júnior, Eduardo

; Garófalo, Denise de Abreu

; Mont´Alverne, Maria Amélia Geraldes Bordalo

; Tavares, Melanie

; Passos, Márcia Maria Barros dos

; Freitas, Zaida Maria Faria de

; Santos, Elisabete Pereira dos

; Monteiro, Mariana Sato de Souza de Bustamante

Brazilian Journal of Pharmaceutical Sciences

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2023, Volume 59 elocation e21425

Abstract: En | Text: En | PDF: En

Abstract The University Pharmacy Program (FU), from the Federal University of Rio de Janeiro (UFRJ), was created based on the need to offer a curricular internship to students of the Undergraduate Course at the Faculty of Pharmacy. Currently, it is responsible for the care of about 200 patients/day, offering vacancies for curricular internships for students in the Pharmacy course, it has become a reference in the manipulation of many drugs neglected by the pharmaceutical industry and provides access to medicines for low-income users playing an important social function. Research is one of the pillars of FU-UFRJ and several master and doctoral students use the FU research laboratory in the development of dissertations and theses. As of 2002, the Pharmaceutical Care extension projects started to guarantee a rational and safe pharmacotherapy for the medicine users. From its beginning in 1982 until the current quarantine due to the COVID-19 pandemic, FU-UFRJ has been adapting to the new reality and continued to provide patient care services, maintaining its teaching, research, and extension activities. The FU plays a relevant social role in guaranteeing the low-income population access to special and neglected medicines, and to pharmaceutical and education services in health promotion. FU, , (FU) UFRJ, UFRJ (UFRJ) Currently 20 patientsday patients day patients/day course lowincome low income function FUUFRJ theses 2002 198 COVID19 COVID 19 COVID-1 pandemic teaching activities promotion (FU (UFRJ 2 COVID1 1 COVID-

https://doi.org/10.1590/s2175-97902023e21425

13.

Accuracy of DRIS and CND methods and nutrient sufficiency ranges for soybean crops in the Northeast of Brazil
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Souza, Henrique Antunes de

; Rozane, Danilo Eduardo

; Vieira, Paulo Fernando de Melo Jorge

; Sagrilo, Edvaldo

; Leite, Luiz Fernando Carvalho

; Brito, Lucélia Cássia Rodrigues de

; Conceição, Mariana Passos

; Ferreira, Ane Caroline Melo

Acta Scientiarum. Agronomy

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2023, Volume 45 elocation e59006

Abstract: En | Text: En | PDF: En

ABSTRACT. This study aimed to evaluate the nutrition of commercial soybean crops in an agricultural frontier region using the diagnosis and recommendation integrated system (DRIS) and compositional nutrient diagnosis (CND) methods, as well as identify sufficiency ranges. The study was performed by collecting leaf samples (third trifoliate leaf without petiole) at flowering from commercial soybean crops in the states of Piauí and Maranhão, Brazil, and evaluating the crop yield by analyzing macro- and micronutrients in the plant tissue of 98 samples. The DRIS and CND methods were applied based on the cataloged data, followed by the generation of norms, analysis of relationships between yield and nutrients (selecting high-yield crops by the cumulative function of the data), generation of sufficiency ranges, and comparison of methods. The relationships obtained by the DRIS and CND indices with the yield and nutrients were significant, indicating that both methods can be employed for the evaluation of leaf nutrients in soybean. The sufficiency ranges from the DRIS and CND methods presented superior nutrient ranges in relation to the values proposed in the literature for macronutrients, except for nitrogen, and greater range amplitudes for micronutrients. ABSTRACT (DRIS (CND third petiole Maranhão Brazil macro 9 data norms selecting highyield high , data) significant macronutrients nitrogen

https://doi.org/10.4025/actasciagron.v45i1.59006

14.

Síndrome de Dunbar - relato de caso
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Campos, Sarah Maria Lemos de

; Pessoa, Rafael Prado

; Pelegrini, João Paulo de Araújo

; Silveira, Henrique Fernandes

; Diniz, Maria Fernanda Lopes

; Bianchini, Maria Passos

; Lopes, Leonardo Soares

; Costa, Marcus Eduardo Valadares Meireles Martins da

Jornal Vascular Brasileiro

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2023, Volume 22 elocation e20230030

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

Abstract Dunbar syndrome is diagnosed by excluding other possible causes of abdominal pains. Surgical treatment comprises complete dissection of the ligament and the surrounding nerve ganglion. This report describes the case of a previously healthy 45-year-old male patient who presented with epigastric abdominal pain irradiating to the back and weakness. Initially, abdominal computed tomography was ordered, showing arteriopathy of the celiac trunk and mesenteric artery with stenosis. The patient underwent surgical treatment because of the refractory pain, but findings were nonspecific. It was necessary to continue workup with serial angiotomography to follow the case. After around 6 months, thickening of the arcuate ligament was found, with compression of the proximal third of the celiac trunk and 80% stenosis. The patient therefore underwent laparoscopy to relieve celiac trunk compression, with satisfactory postoperative recovery. pains ganglion 45yearold yearold 45 year old weakness Initially ordered stenosis nonspecific months found 80 recovery 4 8

Resumo A síndrome de Dunbar constitui um diagnóstico de exclusão dentro dos quadros de dor abdominal. O tratamento cirúrgico consiste na dissecção completa do ligamento e do gânglio nervoso circundante. Dessa forma, o presente caso refere-se a um paciente do sexo masculino, 45 anos, previamente hígido, com queixa de dor abdominal epigástrica com irradiação para o dorso e fraqueza. Inicialmente, foi realizada tomografia computadorizada de abdome para complementação do quadro, que evidenciou arteriopatia do tronco celíaco e da artéria mesentérica em associação com estenose. Optou-se por tratamento cirúrgico devido à refratariedade da dor, mas os achados foram inespecíficos. Houve necessidade de complementação da propedêutica com angiotomografia seriada para acompanhamento do caso. Após cerca de 6 meses, notou-se espessamento do ligamento arqueado, com compressão do terço proximal do tronco celíaco e estenose de 80%. Em meio a esse cenário, o paciente foi submetido a laparoscopia para descompressão do tronco celíaco, evoluindo satisfatoriamente no pós-operatório. circundante forma referese refere se masculino 4 anos hígido fraqueza Inicialmente quadro Optouse Optou inespecíficos meses notouse notou arqueado 80 80% cenário pósoperatório. pósoperatório pós operatório. operatório pós-operatório 8

https://doi.org/10.1590/1677-5449.202300301

15.

Chemical attributes of an Oxisol with the addition of conilon coffee straw biochar
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Alvarenga, Anarelly Costa

; Passos, Renato Ribeiro

; Andrade, Felipe Vaz

; Mendonça, Eduardo de Sá

; Rangel, Otacílio José Passos

; Mosa, Lázaro Longue

Pesquisa Agropecuária Brasileira

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2023, Volume 58 elocation e03019

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

Abstract The objective of this work was to evaluate the effects of increasing rates of biochar produced with coffee straw, at two pyrolysis temperatures, on the chemical attributes of an Oxisol cultivated with conilon coffee (Coffea canephora) and on the nutrient content of coffee tree leaves. Treatments consisted of pyrolysis at two temperatures (350 and 600 °C) and of five biochar rates (0, 5, 10, 15, and 20 Mg ha-1). The following soil chemical attributes were evaluated: pH in water; P, K, Ca, Mg, Al, H+Al, Zn, Cu, Fe, and Mn contents; effective and potential cation exchange capacity (CEC); sum of bases (SB); base (V) and aluminium (m) saturation; and N, P, K, Ca, Mg, Zn, Cu, Fe, and Mn contents in the leaves. The biochar produced at 600°C, at rates of 10 and 15 Mg ha-1, promoted a greater K release into the soil. Regardless of temperature, coffee straw biochar increased K and P availability, sum of bases, base saturation, and CEC in the soil, but did not influence macro- and micronutrient contents in the leaves. The addition of increasing rates of coffee straw biochar in the soil increases P, K, Mg, SB, CEC, and V, regardless of pyrolysis temperature. Coffea canephora leaves 350 (35 60 °C C 0, 0 (0 5 2 ha1. ha1 ha 1 . ha-1) evaluated water Ca Al HAl H H+Al Zn Cu Fe (CEC) SB (SB) V (V m (m saturation N 600C 600°C ha1, 1, ha-1 temperature availability macro 35 (3 6 ( (CEC (SB ha- 3

Resumo O objetivo deste trabalho foi avaliar os efeitos de doses crescentes de biocarvão produzido com palhada de café, em duas temperaturas de pirólise, nos atributos químicos de um Latossolo cultivado com cafeeiro conilon (Coffea canephora), e no conteúdo de nutrientes das folhas do cafeeiro. Os tratamentos consistiram de duas temperaturas de pirólise (350 e 600°C) e cinco doses de biocarvão (0, 5, 10, 15 e 20 Mg ha-1). Avaliaram-se os seguintes atributos químicos do solo: pH em água; teores de P, K, Ca, Mg, Al, H+Al, Zn, Cu, Fe e Mn; capacidade de troca catiônica efetiva e potencial (CTC); soma de bases (SB); saturação por bases (V) e por alumínio (m); e teores de N, P, K, Ca, Mg, Zn, Cu, Fe e Mn nas folhas. O biocarvão produzido a 600°C, nas doses de 10 e 15 Mg ha-1, promoveu maior liberação de K ao solo. Independentemente da temperatura, o biocarvão promoveu o aumento de P e K disponíveis, SB, V e CTC no solo, mas não influenciou os conteúdos dos macro e micronutrientes das folhas. A adição de doses crescentes de biocarvão da palha de café conilon no solo promove aumento de P, K, Mg, SB, CTC e V, independentemente da temperatura de pirólise. Coffea canephora, canephora , canephora) 350 (35 600°C 600C C 600 0, 0 (0 5 1 2 ha1. ha1 ha . ha-1) Avaliaramse Avaliaram se água Ca Al HAl H H+Al Zn Cu (CTC) SB (SB) (V m (m) N ha1, 1, ha-1 disponíveis 35 (3 60 ( (CTC (SB (m ha- 3 6

https://doi.org/10.1590/s1678-3921.pab2023.v58.03019

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