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Parenting Styles and Coping Strategies in PKU Early Detected Children
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Campos, María L. Pardo

; Enacan, Rosa

; Valle, Maria G.

; Chiesa, Ana

Journal of Inborn Errors of Metabolism and Screening

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2021, Volume 9 elocation e20200014

Abstract: En | Text: En | PDF: En

Abstract Phenylketonuria (PKU) requires tight control to prevent neurocognitive impairment but reports show that patients may present mild cognitive defects related to higher impulsivity. We hypothesize that chronic intervention may influence the parents and child bonding and the child´s resources to face problems. To describe the PKU parenting styles perceived by the children (PS) and their coping strategies (CS) assessing their relationship with impulsivity, 30 early diagnosed and adequately treated PKU children and 30 non PKU aged-paired controls (CG) were compared. The Argentine Children´s Coping Questionnaire, Argentine Scale Perception of the Relationship with Parents, WISC IV Comprehension Subtest, and CPT II test were administered. PKU PS were based on control: strict to pathologic in the mother and acceptable in the father (both p<0.05 vs. CG). Children significantly sought greater support and showed less emotional control when facing conflicts. These characteristics positively correlated with maternal control r:.383 and r:.398 (both p<0.05). Impulsivity was higher in PKU (p<0.05) but didn´t associate with PS or CS. Maternal strict control wasn´t linked to the higher impulsivity found (possibly neurobiologically based). Nevertheless, if both factors are present, patients may develop a psychological and/or behavioral trait of greater dependency and impulsivity that must be considered in their follow-up.

https://doi.org/10.1590/2326-4594-jiems-2020-0014 491 downloads

Trisomía 9, trisomía 13 y trisomía 18: Resultados del análisis citogenético prenatal, Hospital Clínico Universidad de Chile, años 2000-2017
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Pardo, Rosa

; Zavala, María

; Sanz, Patricia

; Daher, Vera

; Tobella, Lorena

; Salazar, Samuel

; Sanhueza, Carolina

; Castillo, Silvia

Revista chilena de obstetricia y ginecología

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aug 2020, Volume 85 N. 4 Pages 335 - 342

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

ABSTRACT Introduction: In Chile, the technical standard of Law No. 21,030 of 2017 considers three aneuploidies as lethal; trisomies 9, 13 and 18, whose diagnosis is confirmed with a Karyotype. To date there is not a national registry of prenatal frequency of these pathologies. Objective: To determine the frequency of trisomies 9, 13 and 18 in prenatal cytogenetic studies in samples of cells obtained with amniocentesis and cordocentesis, processed in the Cytogenetics Laboratory of the Universidad de Chile Clinical Hospital. Materials and methods: Descriptive and retrospective study of the results of karyotypes of amniotic fluid (LA) and fetal blood (SF) processed from January 2000 to December 2017. Results: 2,305 samples (402 of SF and 1,903 of LA) were included, of which 438 (19%) were lethal trisomies (TL), corresponding to free TL 416 (95%), structural TL 12 (2,7%) and mosaics 10 (2.3%). Trisomy 18 was the most frequent in both types of sample (73,5 %), followed by trisomy 13 (24,2%) and trisomy 9 (2.3%). Results are shown according to the type of TL, sample, reason for referral, maternal age and gestational age. Conclusions: The karyotype confirms the diagnosis of aneuploidies and provides relevant data for genetic counseling. The most frequent lethal chromosomopathy was trisomy 18. It was observed that one in five karyotypes referred for congenital anomalies and / or aneuploidy markers revealed a TL.

RESUMEN Introducción: En Chile, la norma técnica de la Ley N° 21.030 de 2017 considera tres aneuploidías como letales; las trisomías 9, 13 y 18, cuyo diagnóstico se confirma con un cariograma. No existe a la fecha registro nacional de frecuencia prenatal de estas patologías. Objetivo: Determinar la frecuencia de trisomías 9, 13 y 18 en los estudios citogenéticos prenatales en muestras de células obtenidas con amniocentesis y cordocentesis, procesados en el Laboratorio de Citogenética del Hospital Clínico Universidad de Chile. Materiales y métodos: Estudio descriptivo y retrospectivo de los resultados de cariograma de líquido amniótico (LA) y sangre fetal (SF), procesados desde enero de 2000 a diciembre de 2017. Resultados: Se incluyeron 2.305 muestras (402 de SF y 1.903 de LA), de ellas 442 (19%) fueron trisomías letales (TL), dentro de ellas fueron TL libres 416 (95%), TL estructurales 15 (2,7%) y mosaicos 11 (2,3%). La trisomía 18 fue en ambos tipos de muestra la más frecuente (73,5%), seguida de trisomía 13 (24,2%) y trisomía 9 (2,3%). Se desglosan resultados conforme al tipo de TL, muestra, motivo de derivación, edad materna y edad gestacional. Conclusiones: El cariograma confirma el diagnóstico de aneuploidías y aporta datos relevantes para el consejo genético. La cromosomopatía letal más frecuente fue la trisomía 18. Se observó que uno de cada cinco cariogramas referidos por anomalías congénitas y/o marcadores de aneuploidía revelaban una TL.

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Discriminative validity of an abbreviated Semantic Verbal Fluency Test
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Herrera-García, José David

; Rego-García, Iago

; Guillén-Martínez, Virginia

; Carrasco-García, María

; Valderrama-Martín, Carmen

; Vílchez-Carrillo, Rosa

; López-Alcalde, Samuel

; Carnero-Pardo, Cristóbal

Dementia & Neuropsychologia

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jun 2019, Volume 13 N. 2 Pages 203 - 209

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO. A fluência verbal semântica (SVF) é um dos testes mais utilizados na avaliação cognitiva devido à sua utilidade diagnóstica (UD). Objetivo: Nosso objetivo foi o de avaliar o DU de uma versão abreviada do SVF aplicado em 30 segundos (SVF1-30) para a detecção do comprometimento cognitivo (CC). Métodos: Amostra prospectiva de pacientes avaliados em uma Unidade de Neurologia entre dezembro de 2016 e dezembro de 2017. Global Deterioration Scale (GDS), um teste de SVF (animais), registrando os resultados em 30 e 60 segundos e Fototest, que inclui uma tarefa de fluência de nomes de pessoas foram aplicadas. A UD para CC foi avaliada pela área sob a curva ROC e o tamanho do efeito (“d” Cohen). Resultados: foram incluídos 1012 sujeitos (256 CC e 395 demência). O SVF1-30 mostrou uma boa correlação com o estágio GDS. A UD de SVF1-30 é idêntico ao da versão clássica (SVFtotal) para CC (0,89 ± 0,01; p > 0,50) e sem diferença significativa para demência (0,85 ± 0,01 vs. 0,86 ± 0,01; p > 0,15). Discussão: a UD do SVF1-30 é similar ao SVFtotal, o que permite diminuir o tempo de exploração sem perder a capacidade discriminativa.

ABSTRACT. Semantic verbal fluency (SVF) is one of the most widely used tests for cognitive assessment due to its diagnostic utility (DU). Objective: our objective is to evaluate the DU to detect cognitive impairment (CI) of a short version of the SVF applied in 30 seconds (SVF1-30). Methods: a prospective sample of consecutive patients evaluated in a Neurology Unit between December 2016 and December 2017 were assessed with the Global Deterioration Scale (GDS), 30-second and 60-second SVF tests (animals), and the Fototest, which includes a fluency task of people’s names. The DU for CI was evaluated by the area under the ROC curve and effect size (“d” Cohen). Results: the study included 1012 patients (256 with CI, 395 with dementia). SVF1-30 shows a good correlation with GDS stage. The DU of SVF1-30 is identical to that of the classical version, applied in 60 seconds, (SVFtotal) for CI (0.89 ± 0.01; p > 0.50), and shows no significant difference for dementia (0.85 ± 0.01 vs. 0.86 ± 0.01, p > 0.15). Discussion: the DU of SVF1-30 is similar to that of the SVFtotal, allowing a reduction in examination time with no loss of discriminative capacity.

https://doi.org/10.1590/1980-57642018dn13-020009 1112 downloads

Factores de riesgo maternos y neonatales asociados al retardo de la dentición temporal
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Cobas Pérez, Norayda

; Navarro Nápoles, Josefa

; Pardo González, María Isabel

; Turcas Castellanos, Mirtha Iris

; Rosa Castañeda, Ceila

MEDISAN

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feb 2018, Volume 22 N. 2 Pages 192 - 199

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

An analytic, observational, of cases and controls study, in children from "Pétalos de Rosa" and "La Espiguita" day care centers, belonging to the health area of "Armando García Aspurú" Teaching Polyclinic was carried out in Santiago de Cuba, during February, 2015 to March, 2016, aimed at determining the maternal and neonatal factors associated with the delay in the emergence of the temporary teeth. The population was conformed by 150 children from 2nd to 4th years of life, from whom 2 controls were taken (N=100) for each case (N=50). In the series a statistically significant association of the variables mother’s nutritional state, mother’s weight gain, maternal diseases, breast feeding and child birth weight was obtained, with the disorder of the temporary teething eruption in the children. It was suggested to carry out educational interventions in the day care centers and communities to support the family doctor’s work

Se realizó un estudio analítico, observacional, de casos y controles, en niños de los círculos infantiles "Pétalos de Rosa" y "La Espiguita", pertenecientes al área de salud del Policlínico Docente "Armando García Aspurú" de Santiago de Cuba, durante el período de febrero de 2015 a marzo de 2016, con vistas a determinar los factores maternos y neonatales asociados al retraso en la aparición de dientes temporales. La población quedó conformada por 150 niños de 2do a 4to años de vida, de los cuales se tomaron 2 controles (N=100) por cada caso (N=50). En la serie se obtuvo asociación estadísticamente significativa de las variables estado nutricional de la madre, ganancia de peso de la madre, enfermedades maternas, lactancia materna y peso del niño al nacer, con la alteración del brote dentario temporal en los niños. Se recomendó realizar intervenciones educativas en los círculos infantiles y las comunidades para apoyar el trabajo del médico de la familia

Mortalidad infantil en el Hospital Docente Ginecoobstétrico de Guanabacoa (1998-2010)
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Álvarez Ponce, Vivian Asunción

; Alonso Uría, Rosa María

; Muñiz Rizo, Milagros

; Galbán Hernández, Osmany

; Pardo Mederos, Julia Maritza

Revista Cubana de Medicina General Integral

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dec 2011, Volume 27 N. 4 Pages 495 - 503

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

Introduction: Infant mortality is an important indicator used to measure the population health status. Among its components, the early neonatal death is a challenge for the gynecology-obstetric specialist since its decrease is mainly related to the obstetric follow-up over pregnancy and delivery period. Objective: To determine the behavior of the infant mortality rate in the Guanabacoa Gynecology-Obstetrics Hospital from January 1, 1998 to December 31, 2010. Methods: A retrospective, cross-sectional and descriptive study was conducted on all children deaths occurred in this institution. Study universe included 74 children deaths from as total of 23 533 live-born. Information was gathered from the Mortality Committee and from the files of the Statistics Department of our Institution. Results: It was noted that infant mortality over those 13 years was of 3.9 x 1000 life-born with a trend to decrease from 2004. The major causes of death included: infections, asphyxia and malformations. Although there was predominance of an early neonatal component, from 2.7 x 1000 live-born, it showed a decrease over study period. Likewise, it is necessary to suggest that from 2008 there were not late neonatal deaths. Conclusions: The 10-years infant mortality was of 3.9 x 1000 live-born with a trend to decrease in the early neonatal component. Sepsis was the major problem for our Institution.

Introducción: La mortalidad infantil constituye un importante indicador que se utiliza para medir el estado de salud de la población. Entre sus componentes, la defunción neonatal precoz representa un reto para el ginecoobstetra, ya que su disminución está fundamentalmente relacionada con el seguimiento obstétrico durante el embarazo y el periodo del parto. Objetivo: Determinar el comportamiento de la tasa de mortalidad infantil, en el Hospital Docente Ginecoobstétrico de Guanabacoa, en el periodo comprendido entre el 1 de enero de 1998 y el 31 de diciembre del 2010. Métodos: Se realizó un estudio descriptivo, transversal y retrospectivo de todas las defunciones infantiles que ocurrieron en la institución. El universo de estudio estuvo conformado por las 74 defunciones infantiles de un total de 23 533 nacidos vivos. La información fue obtenida a partir del Comité de Mortalidad y de los registros del Departamento de Estadística de la Institución. Resultados: Se encontró que la tasa de mortalidad infantil durante esos 13 años fue de 3,9 x 1000 nacidos vivos, con tendencia al decrecimiento a partir de 2004. Las principales causas de muerte fueron infecciones, asfixia y malformaciones. Aunque predominó también el componente neonatal precoz, de 2,7 x 1000 nacidos vivos, este mostró una disminución en el periodo estudiado. Asimismo, vale señalar que desde el año 2008 no ha habido muertes neonatales tardías. Conclusiones: La tasa de mortalidad infantil del decenio fue 3,9 x 1000 nacidos vivos, con tendencia a la disminución del componente neonatal precoz. La sepsis constituyó el principal problema para la institución.

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Biotecnología para el desarrollo y sostenibilidad agroindustrial del Noroeste Argentino
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Castagnaro, Atilio Pedro

; Filippone, María Paula

; Noguera, Aldo Sergio

; Perera, María Francisca

; Vellicce, Gabriel Ricardo

; Mamaní, Alicia Inés

; Ontivero, Marta Inés

; Arias, Marta Eugenia

; Racedo, Josefina

; García, María Gabriela

; Paz, Nora

; Díaz, María Elena

; Sendín, Lorena Noelia

; Pardo, Esteban Mariano

; Orce, Ingrid Georgina

; Rocha, Carla María Lourdes

; Sepúlveda Tusek, Mlena

; Martínez Zamora, Gustavo

; Salazar, Sergio Miguel

; Dantur, Karina Inés

; Rigano, Luciano

; Torres, Pablo

; Chalfoun, Nadia Regina

; Maraño, María Rosa

; Vojnov, Adrián

; Ploper, Leonardo Daniel

; Díaz Ricci, Juan Carlos

BAG. Journal of basic and applied genetics

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jun 2011, Volume 22 N. 1

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

In 1994, a group whose aims were both scientific research and technological development was set up. This team was inspired by the increasing demand of the agro-industrial sector in the North West of Argentina. Besides financial considerations inherent to the productive process, social and environmental issues were borne in mind when research had to be carried out. The conceptual premises of scientific work were the study, preservation and a judicious use of biodiversity; equally important was the relentless search for phytosanitary management alternatives which were friendly to both humans and the environment. Thus, in 1997, the frst National Program of Strawberry Genetic Breeding in Argentina started at INSIBIO (CONICET-UNT), Tucumán. This Institute coordinated this program on a national level. Thanks to an agreement between INSIBIO and the Estación Experimental Agroindustrial Obispo Colombres (EEAOC), in 2002, the EEAOC's Biotechnology Department, a Unit Associated to INSIBIO, was founded. One of the main goals of this department was both to develop and adapt technologies to support institutional ongoing programs which intended not only to increase productivity but also to confer more sustainability to those agro-industries related to sugar and alcohol, soybean and citrus. and most importantly, a new scientific and technological team constituted by professionals working with other groups from different research centers nationwide carne into existence. Their common goal has been the improvement of agro-industrial productive processes in order to help build a society which is fair and equitable for both the present and the future.

En 1994 se conformó un grupo de investigación científica y desarrollo tecnológico guiado por la demanda del sector agroindustrial de la región del noroeste argentino, que además de las consideraciones económicas intrínsecas del proceso productivo, tuvo en cuenta para sus investigaciones, aspectos sociales y ambientales. Las premisas conceptuales del trabajo científico fueron el estudio, la preservación y el aprovechamiento de la biodiversidad, en conjunción con la búsqueda continua de alternativas de manejo fitosanitario lo menos reñidas posible con la salud humana y ambiental. Fue así que en 1997 se inició el primer Programa Nacional de Mejoramiento Genético de la Frutilla en Argentina, que desde el INSIBIO (CONICET-UNT) en Tucumán coordinó el trabajo de grupos en otras instituciones. A partir del año 2002 mediante un convenio entre el INSIBIO y la Estación Experimental Agroindustrial Obispo Colombres (EEAOC), se fundó la Sección Biotecnología de la EEAOC- Unidad Asociada al INSIBIO, con el principal objetivo de desarrollar y adaptar tecnologías para apoyar programas institucionales preexistentes, tendientes a incrementar la productividad con mayor sostenibilidad en las agroindustrias suero-alcoholera, sojera, y citrícola. Sin embargo, lo más importante es que se constituyó un equipo científico y tecnológico que trabaja en forma articulada con otros grupos de filiación diversa, pero que tienen el objetivo común de mejorar los procesos productivos en la actividad agroindustrial, para contribuir a generar sociedades más justas y solidarias, no sólo en el presente sino para las futuras generaciones.

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Household catastrophic health expenditures: a comparative analysis of twelve Latin American and Caribbean Countries
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Knaul, Felicia Marie

; Wong, Rebeca

; Arreola-Ornelas, Héctor

; Méndez, Oscar

; Bitran, Ricardo

; Campino, Antonio Carlos

; Flórez Nieto, Carmen Elisa

; Fontes, Roberto lunes

; Giedion, Ursula

; Maceira, Daniel

; Rathe, Magdalena

; Valdivia, Martin

; Vargas, Juan Rafael

; Díaz, Juan José

; Econ, María Dolores Montoya

; Valdes, Werner

; Carmona, Ricardo Valladares

; Zuniga, Maria Paola

; Lafontaine, Liv

; Muñoz, Rodrigo

; Pardo, Renata

; Reynoso, Ana María

; Santana, María Isabel

; Vidarte, Rosa

Salud Pública de México

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2011, Volume 53 Suppl. 2 Pages s85 - s95

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

OBJECTIVE: Compare patterns of catastrophic health expenditures in 12 countries in Latin America and the Caribbean. MATERIAL AND METHODS: Prevalence of catastrophic expenses was estimated uniformly at the household level using household surveys. Two types of prevalence indicators were used based on out-of-pocket health expense: a) relative to an international poverty line, and b) relative to the household's ability to pay net of their food basket. Ratios of catastrophic expenditures were estimated across subgroups defined by economic and social variables. RESULTS: The percent of households with catastrophic health expenditures ranged from 1 to 25% in the twelve countries. In general, rural residence, lowest quintile of income, presence of older adults, and lack of health insurance in the household are associated with higher propensity of catastrophic health expenditures. However, there is vast heterogeneity by country. CONCLUSIONS: Cross national studies may serve to examine how health systems contribute to the social protection of Latin American households.

OBJETIVO: Comparar los patrones de gastos catastróficos en salud en 12 países de América Latina y el Caribe. MATERIAL Y MÉTODOS: Se estimó la prevalencia de gastos catastróficos de manera uniforme para doce países usando encuestas de hogares. Se emplearon dos tipos de indicadores para medir la prevalencia basados en el gasto de bolsillo en salud: a) en relación con una línea de pobreza internacional; y b) en relación con la capacidad de pago del hogar en términos de su propia canasta alimentaria. Se estimaron razones para comparar el nivel de gastos catastróficos entre subgrupos poblacionales definidos por variables económicas y sociales. RESULTADOS: El porcentaje de hogares con gastos catastróficos variaron de 1 a 25% en los 12 países. En general, la residencia rural, el bajo nivel de ingresos, la presencia de adultos mayores, y la carencia de aseguramiento en salud de los hogares se asocian con mayor propensión a sufrir gastos catastróficos en salud. Sin embargo, existe una marcada heterogeneidad por país. CONCLUSIONES: Los estudios comparativos entre países pueden servir para examinar cómo los sistemas de salud contribuyen a la protección social de los hogares en América Latina.

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Household catastrophic health expenditures: a comparative analysis of twelve Latin American and Caribbean Countries
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Knaul, Felicia Marie

; Wong, Rebeca

; Arreola-Ornelas, Héctor

; Méndez, Oscar

; Bitran, Ricardo

; Campino, Antonio Carlos

; Flórez Nieto, Carmen Elisa

; Fontes, Roberto lunes

; Giedion, Ursula

; Maceira, Daniel

; Rathe, Magdalena

; Valdivia, Martin

; Vargas, Juan Rafael

; Díaz, Juan José

; Econ, María Dolores Montoya

; Valdes, Werner

; Carmona, Ricardo Valladares

; Zuniga, Maria Paola

; Lafontaine, Liv

; Muñoz, Rodrigo

; Pardo, Renata

; Reynoso, Ana María

; Santana, María Isabel

; Vidarte, Rosa

Salud Pública de México

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2011, Volume 53 Suppl. 2 Pages s85 - s95

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

3341 downloads Cited 4 times in SciELO

Conocimiento sobre el ácido fólico en la prevención de defectos de cierre del tubo neural: una encuesta a mujeres que viven en Santiago de Chile
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Pardo V, Rosa A

; Lay-Son R, Guillermo

; Aranda Ch, Waldo

; Dib M, Martín

; Espina M, Pablo

; Muñoz K, María J

; Muñoz B, Pilar

; Navarrete C, María F

; Ojeda M, Natalia V

; Parra, Jorge

; Rebolledo D, Cristian A

; Recabal G, Pedro

; Tenhamm T, Tamara

Revista médica de Chile

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dec 2007, Volume 135 N. 12 Pages 1551 - 1557

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

Background: Wheat flour in Chile is fortified with folie acid and pregnant women are also supplemented with the vitamin, but the population level of knowledge or awareness about this vitamin and its use by pregnant women is unknown. Aim: To assess the level of knowledge that postpartum women from Santiago de Chile have about folie acid. Material and methods: A questionnaire about folie acid and its efects on the prevention of neural tube defects was developed adapting questionnaires designed abroad. It was applied by medical students to puerperal women, hospitalized in public hospitals. Results: The questionnaire was applied to 342 women aged 26 ± 7 years. Sixty one percent were housewives and 55% completed high school education. Forty seven percent of these women had heard about folie acid, 9.6% knew that it was able to prevent congenital defects and only one received an adequate supplementation during pregnancy. Women aged 25 to 34 years and those with an adequate medical care during pregnancy had a significantly better knowledge about folie acid and its role in the prevention of congenital anormalies. The more commom means to receive information about folie acid were midwifes (34%), mass media (28%) and doctors (20%). Two hundred eleven women (62%) agreed to take folie acid in a future gestation and 58% preferred to do so using fortified foods. Conclusions: Post partum women from Santiago have a poor knowledge about the relevance of folie acid supplementation

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Exposición a Solventes Orgánicos y Efectos Genotóxicos en Trabajadores de Fábricas de Pinturas en Bogotá
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Cárdenas-Bustamante, Omayda

; Varona-Uribe, Marcela

; Patiño-Florez, Rosa I.

; Groot-Restrepo, Helena

; Sicard-Suárez, Diana

; Tórres-Carvajal, María M.

; Pardo-Pardo, Darío

Revista de Salud Pública

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jun 2007, Volume 9 N. 2 Pages 275 - 288

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

Objective Investigating the degree of exposure to organic solvents and related genotoxic consequences in paint-factory workers by using cytogenetic monitoring and determining micronuclei frequency in lymphocytes and DNA damage as assessed by comet assays. Methodology Excretion of phenol and hippuric and methylhippuric acids in urine was investigated as biomarkers for benzene, toluene and xylene exposure. Urine samples were taken in two paint-factories in Bogotá and in a non-exposed control group. Benzene, toluene and xylene concentrations in air were measured in the work setting. Micronuclei and simple DNA chain breakage frequency were evaluated in peripheral blood sample mononuclear cells to assess early genetic effects. Results Hippuric acid concentration was found to be within normal values; by contrast, phenol and methylhippuric acid sample concentrations were above normal values by 3,3 % and 50,8 %, respectively. Benzene concentration in air was above permissible limits in one of the factories. There were no statistical differences regarding genetic biomarkers between exposed and non-exposed workers. Conclusions Organic solvent levels in the samples were apparently low, which is consistent with the absence of genotoxicity in cells. This study represents a step forward in research in occupational health surveillance.

Objetivo Investigar la exposición a solventes orgánicos y los efectos genotóxicos mediante monitoreo citogenético determinando la frecuencia de micronúcleos en linfocitos y el daño del ADN por el ensayo del cometa, en trabajadores de fábricas de pinturas en Bogotá. Metodología Como biomarcadores de exposición a benceno, tolueno y xileno, la excreción de fenol, ácido hipúrico y ácido metilhipúrico fue investigada en muestras de orina provenientes de trabajadores en dos fábricas de pinturas en Bogotá y de un grupo control. También se realizó monitoreo de la concentración de benceno, tolueno y xileno en el ambiente de trabajo. Como biomarcadores de efectos genéticos tempranos, la frecuencia de micronúcleos y rompimiento de cadenas simples de ADN fueron evaluadas en células mononucleares a partir de muestras de sangre periférica. Resultados Las concentraciones de ácido hipúrico en orina post-exposición se encontraron dentro de los rangos normales, mientras que para fenol el 3,3 % y para ácido metilhipúrico el 50,8 % de las muestras presentaron niveles por encima de los valores de referencia. En una de las fábricas la concentración de benceno en aire estaba por encima de los valores límites permisibles. No hubo diferencias estadísticas entre los trabajadores expuestos y los no expuestos con relación a los biomarcadores genéticos examinados. Conclusiones En este estudio los niveles de solventes orgánicos internamente efectivos parecen ser bajos lo cual se explica con la ausencia de efectos genotóxicos en las células examinadas. Este trabajo constituye un aporte para continuar investigando sobre el tema y a la vez hacer seguimiento por medio del programa de vigilancia epidemiológica.

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11.

Exposición a Solventes Orgánicos y Efectos Genotóxicos en Trabajadores de Fábricas de Pinturas en Bogotá
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Cárdenas-Bustamante, Omayda

; Varona-Uribe, Marcela

; Patiño-Florez, Rosa I.

; Groot-Restrepo, Helena

; Sicard-Suárez, Diana

; M. Tórres-Carvajal, María

; Pardo-Pardo, Darío

Revista de Salud Pública

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apr 2007, Volume 9 N. 2 Pages 275 - 288

Abstract: Es En | Text: Es En | PDF: Es | PDF: En

5031 downloads

12.

Suplementação energético-protéica no desenvolvimento corporal de novilhas Jersey em pastejo
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Pereira, Lília Maria da Rosa

; Fischer, Vivian

; Moreno, Claiton Baes

; Ferreira, Everson Xavier

; Pardo, René Mauricio Patiño

; Gomes, Jorge Fainé

; Monks, Pedro Lima

Revista Brasileira de Zootecnia

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feb 2005, Volume 34 N. 1 Pages 175 - 187

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

O experimento foi desenvolvido com a finalidade de avaliar os efeitos de três tipos de suplementação energética-protéica à base de milho moído e farelo de soja sobre o desenvolvimento corporal de fêmeas Jersey em pastejo. Foram utilizadas 15 novilhas (peso médio de 142,2 ± 7,8 kg e 6 a 18 meses de idade), mantidas em pastejo rotativo, com lotação fixa, em uma pastagem cultivada com azevém anual (Lolium multiflorum, Lam.) e aveia preta (Avena strygosa, Schreb). Foram fornecidos milho moído e farelo de soja, na quantidade equivalente a 0,75% do peso vivo, nos tratamentos: 100% milho moído; 70% milho moído + 30% farelo de soja; e 40% milho moído + 60% farelo de soja. Os animais foram divididos conforme o peso corporal inicial e distribuídos aleatoriamente aos tratamentos, segundo delineamento de blocos completos casualizados em parcelas subdivididas. As avaliações foram feitas durante seis períodos de 28 dias. Não foi observado efeito dos níveis de suplemento sobre ganho médio diário de peso (GMD), ganho total de peso, incrementos de altura e perímetro torácico, provavelmente em razão do nível de massa de forragem e da qualidade nutricional da pastagem utilizada.

The trial was conducted to evaluate the effects of three levels of energy-protein supplementation with corn ground and soybean meal on grazing dairy heifers body development. Fifteen Jersey heifers, aged of 6 to 18 months and weighing 142,2 ± 7,8 kg, were used. Animals were kept under rotational grazing system and fixed stocking rate on a ryegrass and black oats pasture. Animals were classified by their initial body weight and randomly assigned to treatments according to a complete randomized block in a split plot design: 100% corn ground, 70% corn ground + 30% soybean meal, 40% corn ground + 60% soybean meal. Evaluation was performed over six periods of 28 days. No effects for treatments were detected on animals body development attributes as increases in daily live weight gain, total live weight gain, increments of height at withers and heart girt, probably due to high values for pasture quality herbage mass.

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13.

Caracterización clínico-genético-molecular de 45 pacientes chilenos con Síndrome de Prader Willi
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Cortés M, Fanny

; Alliende R, M. Angélica

; Barrios R, Andrés

; Curotto L, Bianca

; Santa María V, Lorena

; Barraza O, Ximena

; Troncoso A, Ledia

; Mellado S, Cecilia

; Pardo V, Rosa

Revista médica de Chile

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jan 2005, Volume 133 N. 1 Pages 33 - 41

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

Background: Prader-Willi syndrome (PWS) is a neurogenetic disease characterized by neonatal hypotonia, retarded mental and motor development, hypogonadism, hyperphagia, morbid obesity and dysmorphic facial features. It has an incidence of 1:12.000-15.000 newborns and is caused by abnormalities in genes located in 15q11q13. PWS is one of the most frequent genetic disorders and microdeletion syndromes. It is also the most common cause of obesity from genetic origin and it was the first disease in which imprinting and uniparental disomy were recognized as cause of genetic disorders. Seventy to seventy five percent of PWS cases are due to 15q11q13 deletions, 20-25% to uniparental disomy and 1% to mutations in the imprinting center. Aim: To analyze the clinical, genetic and molecular features of patients with PWS, seen at one institution. Patients and methods: Retrospective review of 45 patients (27 males) with PWS seen at the Genetics Outpatient Clinic at INTA. Results: Twenty three (51.1%) patients had a delection, 13 (28.9%) patients did not have a deletion. In nine patients, fluorescence in situ hybridization (FISH) study was not performed, therefore the presence of deletion was unknown. The clinical score was 8 points for patients younger than 3 years (n=11) and 11.5 points for patients older than 3 years (n=34); for patients aged 12 months or less, the clinical score was 7 points. Mean clinical score was 11 points for patients with deletion and 10 points for patients without deletion. Conclusions: Most patients with PWS have a deletion; the phenotype depends on age and the clinical score is useful for Chilean patients with PWS (Rev Méd Chile 2005; 133: 33-41).

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14.

Tratamiento de la leucemia aguda no linfoide del niño en Cuba
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Menéndez Veitía, Andrea F

; González Otero, Alejandro

; Corona Rodríguez, Patricia

; Vergara Domínguez, Berta

; Nordet Carrera, Ileana

; Lam Díaz, Rosa María

; Núñez Quintana, Aramís

; Pardo Núñez, Alina

; Machín García, Sergio

; Svarch, Eva

Revista Cubana de Hematología, Inmunología y Hemoterapia

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aug 2004, Volume 20 N. 2

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

Sixty-two children, who presented with all acute non-lymphocytic variants except for the promyelocytic type, were treated with Berlin-Frankfurt-Muster (BFM) group protocols-based intensive chemotheraphy. Initial remission amounted to 56,4 %. Twenty six children died during the induction phase and the most frequent causes were bleeding and infections. At the 60th month, the global survival rate was 37 %, a figure similar to that reported in developed countries. There were no significant differences in terms of survival rates either in the various morphological types or in the age groups at the time of diagnosis

Se les aplicó a 62 niños con todas las variedades de leucemia aguda no linfoide (LANL), excepto en la variedad promielocítica, tratamiento de quimioterapia intensiva basado en los lineamientos del grupo BFM. Se obtuvo el 56,4 % de remisión inicial. Durante la inducción fallecieron 26 niños, y las causas más frecuentes fueron los sangramientos y las infecciones. La sobrevida a los 60 meses fue del 37 %, similar a lo comunicado en países desarrollados. No existieron diferencias en la sobrevida entre los diferentes tipos morfológicos ni de acuerdo con la edad en el momento del diagnóstico

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15.

A dimensão social das doenças: II - positividade das reações de Wasserman e VDRL em convocados para o Serviço Militar no Estado de São Paulo (Brasil), de 1972 a 1978
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Goldenberg, Paulete

; Pardo, Rosa Maria

; Neto, Dalva Regina

; Ribeiro, Sandra Aparecida

; Pernambuco, Maurício

; Iunes, Magid

Revista de Saúde Pública

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jun 1982, Volume 16 N. 3 Pages 133 - 143

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Em seqüência à série histórica iniciada em 1968, com o objetivo de obter indicações sobre a evolução da sífilis no Estado de São Paulo (Brasil), foi feito levantamento dos dados de 1972 a 1978 que mostrou que ao longo do tempo e apesar das oscilações, não houve variações substanciais dos coeficientes de positividade das reações de Wasserman e VDRL em convocados apresentados no município de São Paulo. No interior do Estado o aumento dos valores dos coeficiente de 1973, invertendo a tendência anteriormente observada, aproxima esses índices aos do município. O estudo da subamostra indicou a presença de proporções maiores de positividade em convocados apresentados no município comparados com os apresentados no interior do Estado, independentes da naturalidade, o que poderia sugerir semelhanças com os quadros epidemiológicos descritos para os países desenvolvidos. Entre convocados apresentados na capital observou-se maiores proporções de positividade nos convocados nascidos em outros Estados do país, o que evidenciaria a presença da doença associada à pobreza ou ao subdesenvolvimento. Nesse sentido, foi chamada a atenção para as peculiaridades epidemiológicas das doenças em vista da singularidade das respectivas organizações sociais num dado momento histórico.

Following up the historical series started in 1968, the collection of data from 1972 to 1978 has shown that in the long run, in spite of oscillations, there were no significant variations of the coefficients of positiveness of the Wasserman and VDRL reactions in the boys recruited to the Army in the Capital. In the hinterland the raising on the coefficients' rates, from 1973 on, reverting the tendency previously observed, brought these rates near to those of the Capital. The study of the sub-samples showed the presence of larger proportions of positiveness among the recruits enlisted in the Capital as compared to those in the hinterland, independente of origin which may suggest some similarity to epidemiological reports from developed countries. On the other hand, among the recruits enlisted in the Capital there were larger proportions of positiveness among those born in other States of the country, which could be regarded as evidence of the presence of illness associated with proverty or under-development. In this connection, attention is called by the authors to the epidemiological peculiarities of the illness in view of the singularity of the respective social organizations at a given historical moment.

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