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This investigation describes the synthesis of eugenol analogs presenting 1,2,3-triazole fragments and evaluation of their antileishmanial activity. The alkylation of guaiacol (1) with allyl bromide afforded 1-(allyloxy)-2-methoxybenzene (2) (93% yield). The Claisen rearrangement conducted with 1 gave ortho eugenol (3) (82% yield). Alkylation procedures performed with 3 produced 1-allyl-3-methoxy-2-(prop-2-yn-1-yloxy)benzene (4) (73% yield) and 1-allyl-3-methoxy-2-(pent-4-yn-1-yloxy)benzene (6) (53% yield). The copper(I)-catalyzed alkyne-azide cycloaddition (CuAAC) reactions involving alkynes 4 and 6 with different benzylic azides afforded twenty-two eugenol analogs with 1,2,3-triazole functionalities (48-93% yield). We screened the compounds at 10 μmol L 1 against Leishmania braziliensis intracellular amastigotes during macrophage infection. The action of these compounds was compared with the known leishmanicidal drug amphotericin B. None of the analogs were toxic to macrophages at 10 μmol L-1. The cytotoxic concentration at 50% (CC50), effective concentration at 50% (EC50), and selectivity index (SI) were determined to the best compounds 4-((2-allyl-6-methoxy)phenoxymethyl)-1-(4-chlorobenzyl)-1 H-1,2,3-triazole (8c) and 4-((2-allyl-6-methoxy)phenoxymethyl)-1-(4-trifluoromethoxybenzyl)-1 H-1,2,3-triazole (8h). They showed a significant leishmanicidal effect, with EC50 of 28.09 µmol L-1 (8c) and 52.03 µmol L-1 (8h). The SIs were 9.7 for 8c and > 5.7 for 8h. These compounds have the potential as new leishmanicidal agents against L. braziliensis and may represent a starting point for the development of alternative treatments for cutaneous leishmaniasis.

https://doi.org/10.21577/0103-5053.20230073

Effects of corn straw on meat characteristics of lambs in the Brazilian semi-arid region
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OLIVEIRA, ANA B. DE

; PAULA, TALITA A. DE

; SOUSA, WANDRICK HAUSS DE

; FERREIRA, MARCELO A.

; CARTAXO, FELIPE Q.

; CEZAR, MARCÍLIO F.

; NEVES, MARIA LUCIANA M. WANDERLEY

; BARRETO, LÍGIA MARIA G.

; OLIVEIRA, FLÁVIO G. DE

; GOMES, RAYANE N.

; VÉRAS, ANTONIA SHERLÂNEA C.

Anais da Academia Brasileira de Ciências

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2023, Volume 95 N. 4 elocation e20200395

Abstract: En | Text: En | PDF: En

Abstract The present study aimed to evaluate the influence of increasing levels of corn straw replacement of sorghum silage on average daily gain, loin eye area, subcutaneous fat thickness, weight of commercial cuts, leg tissue composition, and physico-chemical characteristics of the meat from F1 Santa Inês × Dorper lambs maintained in a feedlot system. Treatments consisted of 0, 33, 66 and 100% corn straw replacement of sorghum silage. There were thirty-six 150-day-old male lambs. Corn straw replacement of sorghum silage in lamb feed reduced the average daily gain and weight of the ribs, besides promoting a quadratic influence on leg fat content. However, there was no influence on commercial carcass cuts, leg muscle index, leg tissue composition, and physico-chemical characteristics of the meat. Thus, corn straw can be used as alternative feedstuff for sheep rations to improve the production of high-quality sheep meat in semi-arid regions.

https://doi.org/10.1590/0001-3765202320200395

Interaction of Lead and Calcium with Biochar Produced from Cassava Waste: Perspectives for Agricultural and Environmental Application
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Silva, Ricardo R. da

; Oliveira, Luciana C. de

; Gabriel, Gabriele V. M.

; Soletti, João I.

; Bispo, Mozart D.

; Paulino, Sivaldo S.

; Meneghetti, Simoni M. P.

; Assis, Geovânia C. de

; Fernandes, Andrea P.

; Botero, Wander G.

Journal of the Brazilian Chemical Society

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dec 2022, Volume 33 N. 12 Pages 1402 - 1413

Abstract: En | Text: En | PDF: En

Biochar from slow pyrolysis under controlled conditions is favorable in the transformation of waste into materials that serve as soil conditioners, and/or environmental remediation. Thus, this work aimed to produce and characterize biochar from cassava waste under different temperature conditions and evaluate interactions with Ca2+ and Pb2+ for agricultural and environmental applications. To investigate the efficiency of the interaction of biochar with nutrients (Ca) and contaminants (Pb), the influence of pH and contact time were evaluated. There was an increase in pH, pHzpc (zero point charge), and condensed aromatic structures in BC, due to the increase in pyrolysis temperature. Also, biochar demonstrated a Pb2+ adsorbed amount of 2.03 to 2.37 mg g-1 and a Ca2+ release capacity of 0.655 to 0.765 mg g-1. In this way, biochar produced from residues of cassava waste can be a viable strategy to enhance agricultural production and reduce environmental contaminants.

https://doi.org/10.21577/0103-5053.20220076

Sanitary and physiological quality of soybean seeds treated with Eucalyptus spp. essential oils
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Oliveira, Augusto M.

; Santos, Alice M. G.

; Silva, Luciana B.

; Souza, João S. N.

; Silva, Helane F.

; Lima, Juliana J. P.

; Nunes, Túlio S.

; Leão, Katyuscya V.

; Machado, Luciana L.

Revista de Ciências Agrárias

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sep 2022, Volume 45 N. 3 Pages 41 - 50

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

Abstract Soybean seeds are usually infested by fungi, and disinfestation has been carried out mainly with synthetic fungicides, however, alternative controls have been sought, including essential oils. Thus, the effect of essential oils extracted from the leaves of the hybrid Eucalyptus tereticornis x E. urophylla (HEtu) and E. grandis x E. urophylla (HEgu) in the sanitary and physiological quality of soybean seeds was evaluated. The sanity test was conducted out in completely randomizes design (CRD), factorial scheme 2x5 (two essential oils, in five concentrations: 0, 0.5, 0.75, 1.0 and 2.0 µL.mL-1), the seeds were placed in gerbox boxes in an incubator at 20 ºC for seven days, the fungi were identified according to their morphology. The physiological quality was evaluated in CRD, factorial scheme 2x4+1, being: two essential oils, in four concentrations (0.5, 0.75, 1.0 and 2.0 µL.mL-1), plus an additional control treated with autoclaved distilled water, after eight days, the percentage of germination, percentage of abnormal seedlings and percentage of dead seeds were evaluated. The oils were efficient in controlling the Fusarium and Cladosporium genera, especially at concentrations of 1.0 and 2.0 µL.mL-1. HEgu oil was more efficient in sanitary control, while HEtu oil was superior in all physiological variables. Despite the greater efficiency in sanitary control, HEgu oil negatively alters the physiological quality of the seeds, while HEtu oil at a concentration of 2.0 µL.mL-1, in addition to the efficiency in phytosanitary control, does not affect the physiological quality of the seeds.

Resumo As sementes de soja geralmente são infestadas por fungos, e a desinfestação tem sido realizada principalmente com fungicidas sintéticos, porém, tem-se buscado controles alternativos, entre eles, óleos essenciais. Assim, avaliou-se o efeito de óleos essenciais extraídos das folhas dos híbridos Eucalyptus tereticornis x Eucalyptus urophylla (HEtu) e Eucalyptus grandis x Eucalyptus urophylla (HEgu) na qualidade sanitária e fisiológica de sementes de soja. O teste de sanidade foi conduzido em delineamento inteiramente casualizado (DIC), esquema fatorial 2x5 (dois óleos essenciais, em cinco concentrações: 0; 0,5; 0,75; 1,0 e 2,0 µL.mL-1), as sementes foram colocadas em caixas gerbox em incubadora a 20 ºC por sete dias, os fungos foram identificados de acordo com sua morfologia. A qualidade fisiológica foi avaliada em DIC, esquema fatorial 2x4+1, sendo: dois óleos essenciais, em quatro concentrações (0,5; 0,75; 1,0 e 2,0 µL.mL-1), mais uma testemunha adicional tratada com água destilada autoclavada, após oito dias foram avaliadas a Percentual de germinação, Percentual de plântulas anormais e Percentual de sementes mortas. Os óleos mostram-se eficientes no controle dos gêneros Fusarium e Cladosporium, especialmente nas concentrações de 1,0 e 2,0 µL.mL-1. O óleo do HEgu foi mais eficiente no controle sanitário, enquanto que o do HEtu foi superior para todas as variáveis fisiológicas. Apesar da maior eficiência no controle sanitário, o óleo do HEgu prejudica a qualidade fisiológica das sementes, enquanto que o do HEtu na concentração de 2,0 µL.mL-1 além da eficiente no controle fitossanitário não prejudica a qualidade fisiológica das sementes.

https://doi.org/10.19084/rca.26529

Unveiling the Bacterial Sesquiterpenome of Streptomyces sp. CBMAI 2042 Discloses Cyclases with Versatile Performances
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Sachito, Douglas C.

; Oliveira, Luciana G. de

Journal of the Brazilian Chemical Society

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jul 2022, Volume 33 N. 7 Pages 734 - 742

Abstract: En | Text: En | PDF: En

Terpenes are the most abundant class of natural product that exist in nature. They possess a myriad of industrial applications including pharmaceutical, perfumery and flavors, bulk chemicals, and fuel. Intriguingly, until today, the vast majority of characterized terpenoids have been isolated from plants and fungi, and only in recent years bacteria were found to generate a representative reservoir of terpenoids molecules. Mining Streptomyces sp. CBMAI 2042 genome data has revealed the presence of five terpene cyclase genes. Chemical analysis of mycelium extract of this bacteria strain has unveiled at least 28 volatile terpenes molecules, where three encoding sesquiterpene cyclase (STC) genes are apparently responsible for their biosynthesis. The cyclic products obtained by incubation of these three purified recombinant STCs with farnesyl diphosphate (FPP) were analyzed by gas chromatography-mass spectrometry (GC-MS) and identified using the Van den Dool and Kratz equation.

https://doi.org/10.21577/0103-5053.20220013

O Teste de Caminhada de 6 Minutos prevê a melhora física em longo prazo de sobreviventes à unidade de terapia intensiva: um estudo de coorte prospectiva
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Rosa, Regis Goulart

; Dietrich, Camila

; Valle, Enio Luiz Tschiedel do

; Souza, Denise

; Tagliari, Luciana

; Mattioni, Mariana

; Tonietto, Túlio Frederico

; Rosa, Rosa da

; Barbosa, Mirceli Goulart

; Lovatel, Gisele Agustini

; Lago, Pedro Dal

; Oliveira, Eubrando Silvestre

; Sganzerla, Daniel

; Andrade, Juliana M. S.

; Berto, Paula

; Cardoso, Paulo Ricardo

; Sanchez, Evelin Carneiro

; Falavigna, Maicon

; Maccari, Juçara G.

; Rech, Gabriela

; Robinson, Caroline

; Schneider, Daniel

; Leon, Patrícia de

; Biason, Lívia

; Teixeira, Cassiano

Revista Brasileira de Terapia Intensiva

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sep 2021, Volume 33 N. 3 Pages 374 - 383

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Objetivo: Avaliar a capacidade do Teste de Caminhada de 6 Minutos para predizer a melhora do estado funcional físico em longo prazo de pacientes sobreviventes à unidade de terapia intensiva. Métodos: Foram avaliados, de forma prospectiva, entre fevereiro de 2017 e agosto de 2018, em um ambulatório pós-unidade de terapia intensiva, 32 sobreviventes à unidade de terapia intensiva. Foram inscritos consecutivamente os pacientes com permanência na unidade de terapia intensiva acima de 72 horas (para admissões emergenciais) ou acima de 120 horas (para admissões eletivas) que compareceram ao ambulatório pós-unidade de terapia intensiva 4 meses após receberem alta da unidade de terapia intensiva. A associação entre a distância percorrida no Teste de Caminhada de 6 Minutos realizado na avaliação inicial e a evolução do estado funcional físico foi avaliada durante 8 meses, com utilização do Índice de Barthel. Resultados: A distância média percorrida no Teste de Caminhada de 6 Minutos foi significantemente mais baixa nos sobreviventes à unidade de terapia intensiva do que na população geral (405m versus 557m; p < 0,001). A idade (β = -4,0; p < 0,001) e a fraqueza muscular (β = -99,7; p = 0,02) se associaram com a distância percorrida no Teste de Caminhada de 6 Minutos. A distância percorrida no Teste de Caminhada de 6 Minutos se associou com melhora do estado funcional físico no período de 8 meses de acompanhamento desses pacientes (razão de chance para cada 10m: 1,07; IC95% 1,01 - 1,16; p = 0,03). A área sob a curva Característica de Operação do Receptor para predição da melhora funcional física pelo Teste de Caminhada de 6 Minutos foi de 0,72 (IC95% 0,53 - 0,88). Conclusão: O Teste de Caminhada de 6 Minutos, realizado 4 meses após a alta da unidade de terapia intensiva, predisse com precisão moderada a melhora do estado funcional físico de sobreviventes à unidade de terapia intensiva.

ABSTRACT Objective: To evaluate the ability of the 6-Minute Walk Test to predict long-term physical functional status improvement among intensive care unit survivors. Methods: Thirty-two intensive care unit survivors were prospectively evaluated from February 2017 to August 2018 in a post-intensive care unit outpatient clinic in Brazil. Individuals with intensive care unit stays > 72 hours (emergency admissions) or > 120 hours (elective admissions) attending the post-intensive care unit clinic four months after intensive care unit discharge were consecutively enrolled. The association between the 6-Minute Walk Test distance at baseline and physical functional status was assessed over 8 months using the Barthel Index. Results: The mean 6-Minute Walk Test distance was significantly lower in intensive care unit survivors than in the general population (405m versus 557m; p < 0.001). Age (β = -4.0; p < 0.001) and muscle weakness (β = -99.7; p = 0.02) were associated with the 6-Minute Walk Test distance. A 6-Minute Walk Test distance was associated with improvement in physical functional status over the 8-month follow-up (odds ratio for each 10m of 1.07; 95%CI 1.01 - 1.16; p = 0.03). The area under the Receiver Operating Characteristic curve for the 6-Minute Walk Test prediction of physical functional status improvement was 0.72 (95%CI 0.53 - 0.88). Conclusion: The 6-Minute Walk Test performed 4 months after intensive care unit discharge predicted long-term physical functional status among intensive care unit survivors with moderate accuracy.

https://doi.org/10.5935/0103-507x.20210056 132 downloads

Organic Matter Leached from Tropical Soils by Simulated Rain, Hard (NaOH) and Soft (NaNO3) Extractions: A Realistic Study about Risk Assessment in Soils
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Tavares, Maria C.

; Oliveira, Luciana C.

; Pinheiro, José P.

; Cavagis, Alexandre D. M.

; Fernandes, Andrea P.

; Colle, Vinicius Del

; Botero, Wander G.

Journal of the Brazilian Chemical Society

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mar 2021, Volume 32 N. 3 Pages 534 - 541

Abstract: En | Text: En | PDF: En

Alkaline extractions from humic material are used to risk assessment in soils. However, there are questions about the type of extraction most suitable for this evaluation. Thus, this work evaluated different soil extractions in search of realistic environmental conditions (simulated rain). The parameters obtained revealed significant differences between the levels and structural characteristics of organic matter, depending on the extractant used, reinforcing the importance of developing methodologies and analytical procedures that minimize structural changes and may be more representative of the molecular structures of organic matter found in soils. The results showed that the material extracted by simulated rain is similar to the fulvic acids of the soil organic matter extracted by alkaline extraction showing the importance of this type of extraction for risk assessment studies in soils.

https://doi.org/10.21577/0103-5053.20200207 156 downloads

Interaction of Suspended Particulate Material with Cd2+ and Pb2+ in a Brazilian Lagoon Estuarine System
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Silva, Erismarck A. da

; Silva, Andresa M. B. da

; Santos, Jardielson S.

; Colle, Vinicius Del

; Mendonça, Andre G. R.

; Fernandes, Andrea P.

; Oliveira, Luciana C. de

; Botero, Wander G.

Journal of the Brazilian Chemical Society

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jan 2021, Volume 32 N. 1 Pages 137 - 144

Abstract: En | Text: En | PDF: En

The suspended particulate material (SPM) present in waters has fundamental importance for a better understanding of environmental behaviors of aquatic pollutants. This work determined the physicochemical parameters (pH, temperature, conductivity, total organic carbon and metals concentration) in water samples from Mundaú-Manguaba estuarine-lagoon system, Alagoas, Brazil. This work extracted and characterized the organic matter present in SPM in this estuary and studied the interaction of this organic matter with potentially toxic metals (Cd2+ and Pb2+). The results of the physical-chemical parameters evaluated showed influence of the tide and also of anthropic contributions close to the estuary. In fact, the lead concentrations determined (0.10-1.32 mg L-1) are well above that allowed by Brazilian legislation (< 0.010 mg L-1). The organic matter present in the SPM showed a high degree of humification being similar to the organic matter extracted from water and showed strong interaction by Pb2+ ions.

https://doi.org/10.21577/0103-5053.20200163 199 downloads

Imbibition, Germination and Vigor of Gymnanthes Klotzschiana Müll.Arg. Seeds Under Hypoxia
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Rocha, Émerson Couto da

; Oliveira, Luciana Magda de

; Fantinel, Vinícius Spolaor

; Dias, Romell Alves Ribeiro

Floresta e Ambiente

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2020, Volume 27 N. 3 elocation e20170923

Abstract: En | Text: En | PDF: En

Abstract The objective of this study was to assess hypoxia tolerance in Gymnanthes klotzschiana seeds harvested in two areas (Area 1 - subject to flooding; and Area 2 - not subject to flooding) by the imbibition curve, vigor and germination. Seeds of the two areas were submitted to: one (T-1d), three (T-3d), five (T-5d), ten (T-10d) and twenty days under hypoxia (T-20d); in addition to the control (T-0d). All treatments presented three germination stages. The highest germination was achieved in Area 1 T-1d (90%) and the lowest in Area 2 T-20d (31%). The Area 1 seeds required less time and water content to finish their germination, and they presented greater tolerance to hypoxia; a fact proven by the germination and vigor results. G. klotzschiana seeds harvested in an area subject to flooding are more tolerant to hypoxia and are recommended for restoration projects in this type of area.

https://doi.org/10.1590/2179-8087.092317 304 downloads

10.

The validity and reliability of the CAMDEX-DS for assessing dementia in adults with Down syndrome in Brazil
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Fonseca, Luciana M.

; Haddad, Glenda G.

; Mattar, Guilherme P.

; Oliveira, Melaine C. de

; Simon, Sharon S.

; Guilhoto, Laura M.

; Busatto, Geraldo F.

; Zaman, Shahid

; Holland, Anthony J.

; Hoexter, Marcelo Q.

; Bottino, Cassio M.

Brazilian Journal of Psychiatry

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may 2019, Volume 41 N. 3 Pages 225 - 233

Abstract: En | Text: En | PDF: En

Objective: Alzheimer’s disease occurs at a higher prevalence and an earlier age in individuals with Down syndrome (DS) than typically developing individuals. However, diagnosing dementia in individuals with intellectual disability remains a challenge due to pre-existing cognitive deficits. The aim of this study was to investigate the validity and reliability of the Brazilian version of the Cambridge Examination for Mental Disorders of Older People with Down’s syndrome and Others with Intellectual Disabilities (CAMDEX-DS) for individuals with DS. Methods: Two psychiatrists, working independently, evaluated 92 adults with DS ≥ 30 years of age. The concurrent validity of the CAMDEX-DS was analyzed in relation to the gold standard of established international criteria. In a subgroup of 20 subjects, the concurrent validity of the CAMDEX-DS was analyzed in relation to an independent objective assessment of cognitive decline over three years. We analyzed the inter-rater reliability of cognitive assessment. Results: The diagnostic accuracy of the CAMDEX-DS compared to the gold standard was 96.7%. CAMDEX-DS-based diagnosis was considered consistent with cognitive decline. The probability of a participant with dementia having cognitive decline was 83%. Inter-rater reliability for the participant assessment was good, with a kappa of > 0.8 for 93% of the CAMDEX-DS items. Conclusion: The CAMDEX-DS can be considered the first valid and reliable instrument for evaluating dementia in adults with DS in Brazil. Its use in such individuals could improve clinical practice and research.

https://doi.org/10.1590/1516-4446-2018-0033 1639 downloads

11.

Gene Deletion Leads to Improved Valinomycin Production by Streptomyces sp. CBMAI 2042
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Paulo, Bruno S.

; Sigrist, Renata

; Angolini, Célio F. F.

; Eberlin, Marcos N.

; Oliveira, Luciana G. de

Journal of the Brazilian Chemical Society

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mar 2019, Volume 30 N. 3 Pages 673 - 679

Abstract: En | Text: En | PDF: En

The genus Streptomyces represents one of the largest producers of molecules with antibiotic activity. The whole genome sequencing of the endophytic microorganism Streptomyces sp. CBMAI 2042 revealed 35 gene clusters encoding for secondary metabolism including 3 non-ribosomal peptide synthetases (NRPS) and 7 NRPS-hybrids. Combining genome mining and cultivation profile analysis, the depsipeptide ionophore valinomycin was identified as one of the main metabolites produced by this strain. To better understand the metabolic machinery codified in CBMAI 2042 genome an adenylation domain from a hybrid NRPS cluster was deleted through a double crossing knockout experiment. Though the deletion was not plentiful to elucidate the encoded NRP metabolite related to the adenilation domain, an astounding increase of 10.5-fold in valinomycin production was observed in the mutant. These results suggest a metabolic flux redistribution of common substrates as an outcome of a gene target deletion.

https://doi.org/10.21577/0103-5053.20180207 643 downloads

12.

AVANÇOS RECENTES EM BIOSSÍNTESE COMBINATÓRIA DE POLICETÍDEOS: PERSPECTIVAS E DESAFIOS
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Paulo, Bruno S.

; Sigrist, Renata

; Oliveira, Luciana G. de

Química Nova

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jan 2019, Volume 42 N. 1 Pages 71 - 83

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Natural products continue to inspire scientists on the search for biological active structures. Recent advances in synthetic biology allow modifying genes to extend structural diversity present on natural products by changing important functional groups guided through genetic information. In this context, polyketides synthases (PKS) represent a class of enzymes from where the first applications and well succeed modifications were achieved. During the last two decades PKSs have been extensively studied, sequenced and deposited in data banks available to scientific community around the world. This newly wide information associated to different methodologies accessible to modify the PKSs genetic circuits including genetic insertion, gene deletion and gene replacement leads to discovery of new natural products. In this review, the recent advances in combinatorial biosynthesis, as well as modern techniques in synthetic biology to promote structural diversity on natural products will be discussed.

https://doi.org/10.21577/0100-4042.20170307 1389 downloads

13.

SYNTHESIS, LARVICIDAL AND ACETYLCHOLINESTERASE INHIBITORY ACTIVITIES OF CARVACROL/THYMOL AND DERIVATIVES
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Mesquita, Bruna M. de

; Nascimento, Patricia G. G. do

; Souza, Luciana G. S.

; Farias, Iolanda F. de

; Silva, Romézio A. C. da

; Lemos, Telma L. G. de

; Monte, Francisco J. Q.

; Oliveira, Irvila R.

; Trevisan, Maria T. S.

; Silva, Horlando C. da

; Santiago, Gilvandete M. P.

Química Nova

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apr 2018, Volume 41 N. 4 Pages 412 - 416

Abstract: En | Text: En | PDF: En

In order to produce bioactive derivatives of carvacrol and thymol, nine derivatives of each compound were prepared through modifications the phenolic hydroxyl group. The structures of compounds were confirmed by spectral data from MS, IR and NMR. Carvacrol, thymol and derivatives were submitted to the evaluation of the inhibition of the enzyme acetylcholinesterase, using a colorimetric method in which the inhibition of the enzyme is measured by coloration, and larvicidal activity against Aedes aegypti. Derivatives carvacryl acetate-1b and thymyl hexanoate-2b showed the best results for the inhibition of the acetylcholinesterase enzyme, and for the larvicidal activity the derivatives 1a, 1b, 1c, 3h, 2a, 2b, 2c and 4h showed positive results, emphasizing compound thymyl 4-methoxybenzoate-4h which showed LC50 values of 23.60 ppm, considered a very good result.

https://doi.org/10.21577/0100-4042.20170189 946 downloads

14.

Controversial issues in the management of hyperprolactinemia and prolactinomas – An overview by the Neuroendocrinology Department of the Brazilian Society of Endocrinology and Metabolism
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Vilar, Lucio

; Abucham, Julio

; Albuquerque, José Luciano

; Araujo, Luiz Antônio

; Azevedo, Monalisa F.

; Boguszewski, Cesar Luiz

; Casulari, Luiz Augusto

; Cunha Neto, Malebranche B. C.

; Czepielewski, Mauro A.

; Duarte, Felipe H. G.

; Faria, Manuel dos S.

; Gadelha, Monica R.

; Garmes, Heraldo M.

; Glezer, Andrea

; Gurgel, Maria Helane

; Jallad, Raquel S.

; Martins, Manoel

; Miranda, Paulo A. C.

; Montenegro, Renan M.

; Musolino, Nina R. C.

; Naves, Luciana A.

; Ribeiro-Oliveira Júnior, Antônio

; Silva, Cíntia M. S.

; Viecceli, Camila

; Bronstein, Marcello D.

Archives of Endocrinology and Metabolism

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mar 2018, Volume 62 N. 2 Pages 236 - 263

Abstract: En | Text: En | PDF: En

ABSTRACT Prolactinomas are the most common pituitary adenomas (approximately 40% of cases), and they represent an important cause of hypogonadism and infertility in both sexes. The magnitude of prolactin (PRL) elevation can be useful in determining the etiology of hyperprolactinemia. Indeed, PRL levels > 250 ng/mL are highly suggestive of the presence of a prolactinoma. In contrast, most patients with stalk dysfunction, drug-induced hyperprolactinemia or systemic diseases present with PRL levels < 100 ng/mL. However, exceptions to these rules are not rare. On the other hand, among patients with macroprolactinomas (MACs), artificially low PRL levels may result from the so-called “hook effect”. Patients harboring cystic MACs may also present with a mild PRL elevation. The screening for macroprolactin is mostly indicated for asymptomatic patients and those with apparent idiopathic hyperprolactinemia. Dopamine agonists (DAs) are the treatment of choice for prolactinomas, particularly cabergoline, which is more effective and better tolerated than bromocriptine. After 2 years of successful treatment, DA withdrawal should be considered in all cases of microprolactinomas and in selected cases of MACs. In this publication, the goal of the Neuroendocrinology Department of the Brazilian Society of Endocrinology and Metabolism (SBEM) is to provide a review of the diagnosis and treatment of hyperprolactinemia and prolactinomas, emphasizing controversial issues regarding these topics. This review is based on data published in the literature and the authors' experience.

https://doi.org/10.20945/2359-3997000000032 36158 downloads

15.

3rd Guideline for Perioperative Cardiovascular Evaluation of the Brazilian Society of Cardiology
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Gualandro, Danielle Menosi

; Yu, Pai Ching

; Caramelli, Bruno

; Marques, André Coelho

; Calderaro, Daniela

; Fornari, Luciana Savoy

; Pinho, Claudio

; Feitosa, Alina Coutinho Rodrigues

; Polanczyk, Carisi Anne

; Rochitte, Carlos Eduardo

; Jardim, Carlos

; Vieira, Carolina L. Z.

; Nakamura, Debora Y. M.

; Iezzi, Denise

; Schreen, Dirk

; Adam, Eduardo Leal

; D’Amico, Elbio Antonio

; Lima, Emerson Q. de

; Burdmann, Emmanuel de Almeida

; Mateo, Enrique Indalecio Pachón

; Marcondes-Braga, Fabiana Goulart

; Machado, Fabio S.

; Paula, Flavio J. de

; Carmo, Gabriel Assis Lopes do

; Feitosa-Filho, Gilson Soares

; Prado, Gustavo Faibischew

; Lopes, Heno Ferreira

; Fernandes, João R. C.

; Lima, José J. G. de

; Sacilotto, Luciana

; Drager, Luciano Ferreira

; Vacanti, Luciano Janussi

; Rohde, Luis Eduardo Paim

; Prada, Luis F. L.

; Gowdak, Luis Henrique Wolff

; Vieira, Marcelo Luiz Campos

; Monachini, Maristela Camargo

; Macatrão-Costa, Milena Frota

; Paixão, Milena Ribeiro

; Oliveira Junior, Mucio Tavares de

; Cury, Patricia

; Villaça, Paula R.

; Farsky, Pedro Silvio

; Siciliano, Rinaldo F.

; Heinisch, Roberto Henrique

; Souza, Rogerio

; Gualandro, Sandra F.M.

; Accorsi, Tarso Augusto Duenhas

; Mathias Júnior, Wilson

Arquivos Brasileiros de Cardiologia

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sep 2017, Volume 109 N. 3 Pages 1 - 104

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

https://doi.org/10.5935/abc.20170140 100302 downloads

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