ABSTRACT: This study assessed the efficacy of an intra-articular injection of allogeneic adipose tissue-derived from mesenchymal stem cells (AD-MSCs) for the treatment of hip dysplasia in dogs. The study group included 12 otherwise healthy dogs of different breeds, ages, weights, and degrees of hip dysplasia diagnosed using radiography. An orthopedic assessment was performed on all dogs before and at 30, 60, and 90 days after infusion of AD-MSCs(2 × 106cells). On the same days, each dog’s owner answered a questionnaire based on theHelsinkiChronic Pain Index. The data were converted to ordinal data based on the score for each variable, and the Friedman test for multiple comparisons was used to verify the results. Compared with the corresponding values on day 0, orthopedic and gait assessments and owners’ reported pain indexes improved over the 90-day observation period. These results suggested that treatment with allogeneic AD-MSCs significantly reduced the clinical signs associated with hip dysplasia during the study period. However, long-term studies are needed to determine the optimal therapeutic protocol for routine clinical use of AD-MSCs in hip dysplasia.

RESUMO: O objetivo deste estudo foi avaliar a eficácia clínica da aplicação intra-articular de células-tronco mesenquimais alógenas derivadas do tecido adiposo (AD-CTM) no tratamento de cães portadores de osteoartrite secundária a displasia do coxofemoral (DCF). Doze cães de ambos os sexos, diferentes raças, idades e peso, portadores de graus variados de DCF comprovada em radiografia e livres de quaisquer outras alterações clínicas ou ortopédicas, foram utilizados no estudo. Todos os cães foram submetidos a avaliação ortopédica nos dias 0, 30, 60 e 90 após aplicação de AD-CTM na dose de 2 x 106. Além disso, os tutores preencheram a um questionário, baseado no Índice de dor crônica de Helsinque (IDCH) nos mesmos intervalos. Em comparação com o dia 0, observou-se melhora significativa na avalição em locomoção e físico-ortopédica assim como na avaliação dos tutores pelo IDCH ao longo dos 90 dias. Os resultados permitem inferir que as AD-CTM alógenas contribuíram significativamente para a redução dos sinais clínicos comumente associados a DCF durante o período de estudo. Entretanto, há necessidade de estudos de longo prazo para melhor determinação de protocolos terapêuticos baseados no uso de AD-CTM na rotina clínica.

Objective: To describe the methodological and operational aspects of the Cancer Surveillance Project and its associated factors: population-based and hospital-based registry (VIGICAN), in Mato Grosso (MT). Methods: VIGICAN was divided into two projects: an extension one, which updated the data from the Population-Based Cancer Registry (RCBP) of MT in the period 2008 to 2016; and one of research, which collected primary data, through individual interviews and analysis of medical records of people with a diagnosis of cancer, aged 18 years or over, treated at reference hospitals for oncology. To analyze the factors associated with cancer, the following variables were collected: socioeconomic and demographic, social support, status and health behavior, and environmental exposure. Results: In the períod from 2008 to 2016, approximately one hundred thousand cases of cancer (incident and prevalent) were reported in the RCBP Cuiabá and Interior. After validation procedures, fifty thousand incident cases were chosen. The survey interviewed 1,012 patients, 38.2% living in the municipalities of Cuiabá and Várzea Grande, 60.4% in the interior of the state and 1.4% in other states. Preliminary data revealed that the majority were female (55.0%) and younger than 60 years (54.3%). Among those interviewed, 7.2% reported smoking tobacco, 15.5% consumed alcoholic beverages (15.5%) and 32.7% lived close to crops. Conclusion: The development of these projects allowed the integration of education with health services and will enable the recognition of specificities and different exposure scenarios and factors associated with cancer in the Mato Grosso territory.

Objetivo: Descrever os aspectos metodológicos e operacionais do Projeto Vigilância do Câncer e seus fatores associados: registro de base populacional e hospitalar (VIGICAN), em Mato Grosso (MT). Métodos: O VIGICAN se desdobrou em dois projetos: um de extensão, que atualizou os dados dos Registros de Câncer de Base Populacional (RCBP) de MT no período de 2008 a 2016; e um de pesquisa, que coletou dados primários, por meio de entrevistas individuais e análise de prontuários de pessoas com diagnóstico de câncer, com 18 anos ou mais, atendidas em hospitais de referência para oncologia. Para analisar os fatores associados ao câncer, foram coletadas as seguintes variáveis: socioeconômicas e demográficas, suporte social, situação e comportamentos de saúde e exposição ambiental. Resultados: No período de 2008 a 2016, foram notificados nos RCBP Cuiabá e Interior, aproximadamente, 100 mil casos de câncer (incidentes e prevalentes). Após procedimentos de validação, foram eleitos 50 mil casos incidentes. A pesquisa entrevistou 1.012 pacientes, sendo 38,2% residentes nos municípios de Cuiabá e Várzea Grande, 60,4% no interior do estado e 1,4% em outros estados. Os dados preliminares revelaram que a maioria era do sexo feminino (55,0%) e tinha menos de 60 anos (54,3%). Entre os entrevistados, 7,2% relataram fumar tabaco, 15,5% consumiam bebidas alcoólicas (15,5%) e 32,7% moravam próximos a lavouras. Conclusão: O desenvolvimento desses projetos permitiu a integração do ensino com os serviços de saúde e possibilitará o reconhecimento das especificidades e diferentes cenários de exposição e fatores associados ao câncer do território mato-grossense.

RESUMO Objetivo: analisar a acurácia das características definidoras de hipotermia em pacientes em hemodiálise. Métodos: estudo de acurácia diagnóstica, com delineamento transversal, realizado com 124 pacientes de dois centros de diálise. Um modelo de classe latente foi utilizado para a análise de dados. Resultados: o diagnóstico de enfermagem hipotermia esteve presente em 13 (10,48%) participantes do estudo. As características definidoras mais prevalentes foram hipóxia (100%), redução da glicemia sanguínea (83,1%), hipertensão (65,3%), piloereção (45,2%) e pele fria ao toque (41,1%). As características definidoras acrocianose (99,96%) e leitos ungueais cianóticos (99,98%) apresentaram alta sensibilidade. Acrocianose (91,8%), pele fria ao toque (64,8%) e vasoconstrição periférica (91,8%) apresentaram alta especificidade. Conclusão: os indicadores específicos e sensíveis de hipotermia são bons indicadores clínicos para confirmar esse diagnóstico em pacientes em hemodiálise. Os resultados deste estudo podem auxiliar os enfermeiros em seu raciocínio clínico para uma inferência correta de hipotermia.

ABSTRACT Objective: to analyze the accuracy of the defining characteristics of hypothermia in patients on hemodialysis. Methods: a diagnostic accuracy study was assembled within a cross-sectional study with 124 patients from two dialysis centers. A latent class model was used for data analysis. Results: the nursing diagnosis hypothermia was present in 13 (10.48%) study participants. The most prevalent defining characteristics were hypoxia (100%), decrease in blood glucose level (83.1%), hypertension (65.3%), piloerection (45.2%), and skin cool to touch (41.1%). The defining characteristics acrocyanosis (99.96%) and cyanotic nail beds (99.98%) had a high sensitivity. Acrocyanosis (91.8%), skin cool to touch (64.8%), and peripheral vasoconstriction (91.8%) had high specificity. Conclusion: specific and sensitive indicators of hypothermia work as good clinical indicators for confirming this diagnosis in patients on hemodialysis. The study findings can assist nurses in their clinical reasoning for a correct inference of hypothermia.

RESUMEN Objetivo: analizar la exactitud de las características definitorias de la hipotermia en pacientes en hemodiálisis. Métodos: estudio de exactitud diagnóstica, con diseño transversal, realizado con 124 pacientes de dos centros de diálisis. Se utilizó un modelo de clases latentes para el análisis de datos. Resultados: el diagnóstico de enfermería hipotermia estuvo presente en 13 (10,48%) participantes del estudio. Las características definitorias más prevalentes fueron hipoxia (100%), reducción de la glucosa en sangre (83,1%), hipertensión (65,3%), piloerección (45,2%) y piel fría al tacto (41,1%). Las características definitorias de acrocianosis (99,96%) y lechos ungueales cianóticos (99,98%) mostraron alta sensibilidad. La acrocianosis (91,8%), la piel fría al tacto (64,8%) y la vasoconstricción periférica (91,8%) mostraran alta especificidad. Conclusión: los indicadores específicos y sensibles de hipotermia son buenos indicadores clínicos para confirmar este diagnóstico en pacientes en hemodiálisis. Los resultados del estudio pueden ayudar a las enfermeras a inferir correctamente la hipotermia.

RESUMO: Objetivo: Descrever os aspectos metodológicos e operacionais do projeto “Vigilância do câncer e seus fatores associados: registro de base populacional e hospitalar” (VIGICAN), em Mato Grosso (MT). Métodos: O VIGICAN desdobrou-se em dois projetos: um de extensão, que atualizou os dados dos Registros de Câncer de Base Populacional (RCBP) de Mato Grosso no período de 2008 a 2016; e um de pesquisa, que coletou dados primários por meio de entrevistas individuais e análise de prontuários de pessoas com diagnóstico de câncer, com 18 anos ou mais, atendidas em hospitais de referência para oncologia. Para analisar os fatores associados ao câncer, foram coletadas as seguintes variáveis: socioeconômicas e demográficas, suporte social, situação e comportamentos de saúde e exposição ambiental. Resultados: No período de 2008 a 2016, foram notificados nos RCBP Cuiabá e Interior, aproximadamente, 100 mil casos de câncer (incidentes e prevalentes). Após os procedimentos de validação, foram eleitos 50 mil casos incidentes. A pesquisa entrevistou 1.012 pacientes, sendo 38,2% residentes nos municípios de Cuiabá e Várzea Grande, 60,4% no interior do Estado e 1,4% em outros Estados. Os dados preliminares revelaram que a maioria era do sexo feminino (55,0%) e tinha menos de 60 anos (54,3%). Entre os entrevistados, 7,2% relataram fumar tabaco, 15,5% consumiam bebidas alcoólicas (15,5%) e 32,7% moravam próximo a lavouras. Conclusão: O desenvolvimento desses projetos permitiu a integração do ensino com os serviços de saúde e possibilitará o reconhecimento das especificidades e dos diferentes cenários de exposição ao câncer, bem como fatores associados a ele, no território mato-grossense.

ABSTRACT: Objective: To describe the methodological and operational aspects of the “Project for surveillance of cancer and its associated factors: population-based and hospital-based registry” (VIGICAN), in the state of Mato Grosso (MT), Brazil. Methods: VIGICAN was divided into two projects: a university extension one, which updated the data from the Population-based Cancer Registry (PBCR) of MT in the 2008-2016 period; and a research project, which collected primary data, through individual interviews and analysis of medical records of people with a diagnosis of cancer, aged 18 years or older, treated at reference hospitals for oncology. To analyze the factors associated with cancer, the following variables were collected: socioeconomic and demographic, social support, health status and behavior, and environmental exposure. Results: In the 2008-2016 period, approximately one hundred thousand cases of cancer (incident and prevalent) were reported in the PBCR Cuiabá and PBCR Interior. After validation procedures, 50 thousand incident cases were elected. The survey interviewed 1,012 patients, 38.2% living in the municipalities of Cuiabá and Várzea Grande, 60.4% in small cities of the state, and 1.4% in other states. Preliminary data showed that the majority were women (55.0%) and younger than 60 years of age (54.3%). Among the interviewees, 7.2% reported smoking tobacco, 15.5% consumed alcoholic beverages (15.5%), and 32.7% lived nearby crops. Conclusion: The development of these projects allowed the integration of education with health services and will enable the recognition of specificities and different exposure scenarios and factors associated with cancer in the Mato Grosso territory.

BACKGROUND The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants has become a major concern contributing to increased morbidity and mortality worldwide. OBJECTIVES Here we describe the replacement of the Gamma variant of concern (VOC) with Delta in the western Brazilian Amazon. METHODS In this study, we analysed 540 SARS-CoV-2 positive samples determined by qualitative real-time RT-PCR selected in the state of Rondônia between June and December 2021. The positive cohort was sequenced through next-generation sequencing (NGS) and each sample was quantified using real-time RT-qPCR, the whole genome sequence was obtained, SARS-CoV-2 lineages were classified using the system Pango and the maximum likelihood (ML) method was used to conduct phylogenetic analyses. FINDINGS A total of 540 high-quality genomes were obtained, where the Delta VOC showed the highest prevalence making up 72%, with strain AY.43 being the most abundant, while the Gamma VOC was present in 28%, where the P.1 strain was the most frequent. In this study population, only 32.96% (178/540) had completed the vaccination schedule. MAIN CONCLUSIONS This study highlighted the presence of Gamma and Delta variants of SARS-CoV-2 in RO. Furthermore, we observed the replacement of the Gamma VOC with the Delta VOC and its lineages.

ABSTRACT This study aimed to evaluate the yields of by-products and residues and the morphometry of juvenile tambaqui Colossoma macropomum undernutrition with different levels of lysine. Diets were elaborated containing 6.60, 9.72, 12.84, 15.96, 19.08, and 22.20 g kg−1 of total lysine, and these were fed to fish distributed in 18 tanks (310 L each one) for 90 days. Morphometric analysis, measurements of whole fish, by-products, and residues were taken and compared to each other. All variables were validated using ANOVA, Tukey's test, and quadratic regression analysis (P < 0.05). No differences were found for the morphometric variables (P > 0.05). The ratio between morphometric data for the standard and total length showed significance at levels of 9.72 and 15.96 g kg−1 (P = 0.03). The gutted fish and fillets, the protein and lipid contents of the fillets, and the weights and lengths of the intestines did not change (P > 0.05). Moisture was modified with lysine at levels of 22.20 g kg−1 (P = 0.00), and minerals, between 6.60 and 22.20 g kg−1 (P = 0.01). The increase in lysine levels in the diet led to an increase in fin weight (P = 0.00). It was concluded that the addition of lysine in the diet did not directly influence the morphometry and yields of the fish in the juvenile phase, but it did affect the fin waste and the skin by-product.

Abstract Moringa oleifera Lam., is a tree species that has several purposes of use, standing out in the recovery of degraded areas and the use of seeds as biodsorbents in water clarification. However, ony a little is known about the behavior of seed germination under saline conditions, common in soils and water in the Brazilian Northeast. Thus, the objective was to evaluate the increment of water during the soaking and seed germination of M. oleífera that were submitted to different electrical conductivity of the irrigation water. The work was developed following a completely randomized design, with stress simulation employing saline solutions at the concentrations of 0.0; 3.0; 6.0 and 9.0 dS m-1. To determine the soaking curve, the water increment of the soaked seeds in the different saline solutions was monitored at regular intervals with four replications per treatment. To characterize the physiological quality of the seeds, the percentage, first count, speed index, average time and average germination speed were evaluated. The M. oleífera is tolerant to the effect of salinity during the germination phase, however seed vigor is reduced as a function of increased salinity. Soaking the seeds makes begin the phase II of the germination process around 10 hours and extends for up to 50 hours, when phase III begins, they absorb approximately 0.2 g of water and require 86 hours for germination. Salinity reduces the absorption and increase of water in the seeds.

Resumo O objetivo desta pesquisa foi adaptar a Structured Interview for Assessing Perceptual Anomalies (SIAPA) para o Brasil para ser utilizada como instrumento de autorrelato. Utilizou-se uma amostra não probabilística de 854 universitários, a maioria do sexo masculino (51,4 %) e com idades entre 16 e 65 anos (M = 23,7; DP = 6,8). Após a tradução e validação semântica da SIAPA, testaram-se os parâmetros de validade e precisão por meio de análises fatoriais, coeficientes alfa de Cronbach e análises via Teoria de Resposta ao Item (TRI). Os resultados confirmaram a adequação psicométrica da medida, apontando uma solução unidimensional com altas cargas no fator geral e alta consistência interna (α = 0,88; Ω = 0,88). Acredita-se que o objetivo proposto tenha sido satisfeito, de modo que, ao final da pesquisa, contou-se com uma medida válida e fidedigna que pode ser utilizada, tanto para rastreio quanto para pesquisa, para compreender e diagnosticar anomalias perceptuais.

Abstract The purpose of this research was to adapt the Structured Interview for Assessing Perceptual Anomalies (SIAPA) for use in Brazil as a self-report tool. A non-probabilistic sample of 854 undergraduate students was used, mostly men (51.4%) and aged between 16 and 65 years (M = 23.7, SD = 6.8). After the translation and semantic validation of SIAPA, the validity and precision parameters were tested by means of factor analysis, Cronbach’s alpha coefficients, and Item Response Theory (IRT) analysis. The results confirmed the psychometric adequacy of the measure, pointing to a one-dimensional solution with high loads on the general factor and high accuracy (α = 0.88; Ω = 0.88). It is believed that the proposed objective was satisfied, so that at the end of the investigation there was a valid and reliable measure that can be used, both for screening and research, to understand and diagnose perceptual anomalies.

Resumen El objetivo de esta investigación fue adaptar la Structured Interview for Assessing Perceptual Anomalies (SIAPA) para Brasil para utilizarla como instrumento de autoinforme. Se utilizó una muestra no probabilística con 854 universitarios, la mayoría del sexo masculino (51,4%) y con edades entre 16 a 65 años (M = 23,7, DP = 6,8). Después de la traducción y validación semántica de la SIAPA, se probaron los parámetros de validez y precisión por medio de análisis factoriales, coeficientes alfa de Cronbach y análisis vía Teoría de Respuesta al Ítem (TRI). Los resultados confirmaron la adecuación psicométrica de la medida, apuntando una solución unidimensional con altas cargas en el factor general y alta precisión (α = 0,88; Ω = 0,88). Se cree que el objetivo propuesto ha sido satisfecho, de modo que al final de la investigación se contó con una medida valida y fidedigna que se puede utilizar, tanto para detección como investigación, para comprender y diagnosticar anomalías perceptuales.

RESUMO Objetivou-se avaliar os efeitos das doses de biofertilizante com diferentes regimes hídricos sobre o crescimento e a fitomassa de mudas de maracujazeiro amarelo. O experimento foi desenvolvido utilizando um material ou substrato dos primeiros 20 cm de um Neossolo Flúvico Eutrófico. O delineamento utilizado foi o inteiramente casualizado (DIC), com arranjo fatorial 5x2x2, referentes as doses de biofertilizante bovino (0; 200; 400; 600 e 800 mL) diluídos na razão de 1:2, níveis de substrato S1- 70% de solo (1400 mL) + 30% de esterco bovino (600 mL); S2 - 30% de solo (600 mL) + 70% de esterco bovino (1400 mL) e dois níveis de água no solo (ADS): L1 = 100 % da água disponível no substrato (ADS) e L2 = 60% de água disponível no substrato, com 4 repetições, totalizando 80 unidades experimentais. Após a semeadura aos 110 (DAS) foram avaliadas a Área foliar (AF); Fitomassa seca da parte aérea (FSPA); Fitomassa seca da raiz (FSR); Fitomassa seca total (FST); Relação raíz parte aérea (RRPA); Comprimento radicular (CR) e a Correlação de Pearson. Mudas de maracujazeiro em condições de estresse hídrico inibem seu crescimento, mas com biofertilizante e esterco bovino resultam em plantas com maior potencial vegetativo.

ABSTRACT The objective of this study was to evaluate the effects of doses of biofertilizer with different water regimes on the growth and phytomass of yellow passion fruit seedlings. The experiment was carried out using a material or substrate of the first 20 cm of a Eutrophic Floss Neossol. The design used was completely randomized (DIC), with a 5x2x2 factorial arrangement, referring to the doses of bovine biofertilizer (0; 200; 400; 600 and 800 mL) diluted in ratio of 1:2, S1- substrate levels 70% soil (1400 mL) + 30% bovine manure (600 mL); S2 - 30% soil (600 mL) + 70% bovine manure (1400 mL) and two water levels in the soil (ADS): L1 = 100% of the water available in the substrate (ADS) and L2 = 60% water available on the substrate, with 4 repetitions, totaling 80 experimental units. After sowing at 110 (DAS), the leaf area (AF) was evaluated; Dry shoot phytomass (FSPA); Dry root phytomass (FSR); Total dry phytomass (FST); Root part shoot (RRPA); Root length (CR) and Pearson's correlation. Passion fruit seedlings under water stress conditions inhibit their growth, but with biofertilizer and cattle manure they result in plants with greater vegetative potential.

Abstract Hymenaea martiana is a native medicinal plant from the Caatinga, but biochemical studies of the fruit have not yet been reported. Thus, this study aimed to determine sugars and secondary metabolites, as well as assess the sunscreen potential of H. martiana fruits. The fruits were collected in Petrolina and separated into pulp and seeds. The sugar analysis investigated the presence of glucose, xylose, cellobiose, arabinose and xylitol. The determination of secondary metabolites was made through phytochemical screening and sunscreen activity was assessed with the spectrophotometric method. In the fruit pulp, carbohydrates with a great biotechnological potential were identified. The substances found in the phytochemical screening showed great antioxidant, photoprotective and medicinal potential. With the pulp extract, the sun protection factor values obtained were not significant and for the extract from the seeds, the values were 4.54 ± 0.11. Although the values found are below the recommended, the fruit extracts of H. martiana could be used in future development of sunscreen products providing several benefits to the formulation.

Resumo Fundamento: O D-limoneno (DL) é um monoterpeno e o principal componente do óleo essencial de frutas cítricas. Ele apresenta atividades anti-hiperglicêmicas e vasodilatadoras. Objetivos: Este estudo avaliou os efeitos cardiovasculares e antiarrítmicos potenciais do DL em ratos. Métodos: Os parâmetros hemodinâmicos e eletrocardiográficos (ECG) foram mensurados em ratos Wistar machos que, sob anestesia, tiveram a aorta abdominal e a veia cava inferior canuladas e receberam eletrodos implantados subcutaneamente. Na abordagem in vitro, o coração foi removido e perfundido utilizando a técnica de Langendorff. O nível de significância adotado foi de 5% (p < 0,05). Resultados: DL, nas doses de 10, 20 e 40 mg/kg (i.v), produziu bradicardia intensa e persistente associada à hipotensão. A bradicardia com QTc prolongado foi observada no registro in vivo do ECG. No modelo in vivo de arritmia induzida por Bay K8644, DL (10 mg / kg) houve diminuição do escore da arritmia de 15,33 ± 3,52 para 4,0 ± 2,64 u.a (p < 0,05, n = 4). Em corações perfundidos isolados, o DL (10-3 M) promoveu reduções significativas na frequência cardíaca (de 228,6 ± 8,5 ms para 196,0 ± 9,3 bpm; p < 0,05) e na pressão desenvolvida do ventrículo esquerdo (de 25,2 ± 3,4 para 5,9 ± 1,8 mmHg; n = 5, p < 0,05). Conclusões: O DL produz bradicardia e atividade antiarrítmica no coração de ratos.

Abstract Background: D-limonene (DL) is a monoterpene and is the major component in the essential oil of citrus fruit. It presents antihyperglycemic and vasodilatation activities. Objectives: This study evaluated the cardiovascular effects and potential antiarrhythmic of DL in rats. Methods: Hemodynamic and electrocardiographic (ECG) parameters were measured in male Wistar rats, which under anesthesia had been cannulated in the abdominal aorta and lower vena cava and had electrodes subcutaneously implanted. In the in vitro approach, the heart was removed and perfused using the Langendorff technique. The significance level adopted was 5% (p < 0.05). Results: DL, in doses of 10, 20, and 40 mg/kg (i.v), produced intense and persistent bradycardia associated with hypotension. Bradycardia with prolonged QTc was observed in the ECG in vivo recording. In the in vivo model of arrhythmia induced by Bay K8644, DL (10 mg/kg) decreased the arrhythmia score from 15.33 ± 3.52 to 4.0 ± 2.64 u.a (p < 0.05, n = 4). In isolated perfused hearts, DL (10-3 M) promoted significant reductions in heart rate (from 228.6 ± 8.5 ms to 196.0 ± 9.3 bpm; p < 0.05) and left ventricular development pressure (from 25.2 ± 3.4 to 5.9 ± 1.8 mmHg; n = 5, p < 0.05). Conclusions: DL produces bradycardia and antiarrhythmic activity in rat heart.

Resumo O presente estudo refere-se ao impacto do uso de agrotóxicos sobre a saúde humana no Submédio do Vale do São Francisco. Por meio de entrevistas objetivou-se analisar a influência dos condicionantes sociais, culturais e econômicos no processo saúde-doença dos trabalhadores expostos a agrotóxicos. Para a coleta de dados foram entrevistados 339 trabalhadores rurais de perímetros irrigados dos municípios de Juazeiro-BA e Petrolina-PE. Todos do sexo masculino, sendo 182 (53,7%) proprietários rurais e 157 (46,3%) empregados, predominando indivíduos entre 40 e 59 anos entre os proprietários e abaixo de 39 anos entre os trabalhadores. Mais de 50% apresentou baixo nível de escolaridade e 55,2% tinha rendimentos mensais menor ou igual a 2 salários mínimos. Muitos sabem da importância do uso de EPIs e da obrigatoriedade do receituário agronômico para a utilização e a compra de agrotóxicos, entretanto cerca de 40% não usam EPIs ou fazem uso de forma incompleta e 28,9% não apresentam receituário durante a compra. Mais de 9% dos participantes relataram casos de intoxicação, no entanto, menos de 7% procuraram atendimento especializado. Os trabalhadores sabem que o uso de agrotóxicos nas lavouras os expõem a situações de risco, mas essa informação não é suficiente para alterar a conduta no exercício laboral.

Abstract This study refers to the impact of the use of pesticides on human health in the São Francisco River Valley region, in which, through semi-structured interviews, the objective was to analyze the influence of social, cultural and economic determinants on the health-disease process of workers exposed to agrochemicals. For data collection, 339 rural workers from irrigated perimeters of the cities of Juazeiro, in the State of Bahia, and Petrolina, in the State of Pernambuco, were interviewed. All were male, of which 182 (53,7%) were rural owners and 157 (46,3%) were employees, predominantly between 40 and 59 years of age among owners and under 39 among workers. Over 50% have a low level of schooling and 55.2% of them have monthly incomes less than or equal to 2 minimum wages. Many of them know about the importance of wearing personal protective equipment (PPE) and the mandatory license for the use and purchase of agrochemicals. However, about 40% do not use PPE or use it inadequately and 28.9% do not have a license to purchase. More than 9% of participants reported cases of intoxication, however, less than 7% sought specialized care. Workers are aware of the risks that the use of agrochemicals expose them to risk situations, but this does not encourage them to change their worksite behavior.

Resumo O presente estudo refere-se ao impacto do uso de agrotóxicos sobre a saúde humana no Submédio do Vale do São Francisco. Por meio de entrevistas objetivou-se analisar a influência dos condicionantes sociais, culturais e econômicos no processo saúde-doença dos trabalhadores expostos a agrotóxicos. Para a coleta de dados foram entrevistados 339 trabalhadores rurais de perímetros irrigados dos municípios de Juazeiro-BA e Petrolina-PE. Todos do sexo masculino, sendo 182 (53,7%) proprietários rurais e 157 (46,3%) empregados, predominando indivíduos entre 40 e 59 anos entre os proprietários e abaixo de 39 anos entre os trabalhadores. Mais de 50% apresentou baixo nível de escolaridade e 55,2% tinha rendimentos mensais menor ou igual a 2 salários mínimos. Muitos sabem da importância do uso de EPIs e da obrigatoriedade do receituário agronômico para a utilização e a compra de agrotóxicos, entretanto cerca de 40% não usam EPIs ou fazem uso de forma incompleta e 28,9% não apresentam receituário durante a compra. Mais de 9% dos participantes relataram casos de intoxicação, no entanto, menos de 7% procuraram atendimento especializado. Os trabalhadores sabem que o uso de agrotóxicos nas lavouras os expõem a situações de risco, mas essa informação não é suficiente para alterar a conduta no exercício laboral.

Abstract This study refers to the impact of the use of pesticides on human health in the São Francisco River Valley region, in which, through semi-structured interviews, the objective was to analyze the influence of social, cultural and economic determinants on the health-disease process of workers exposed to agrochemicals. For data collection, 339 rural workers from irrigated perimeters of the cities of Juazeiro, in the State of Bahia, and Petrolina, in the State of Pernambuco, were interviewed. All were male, of which 182 (53,7%) were rural owners and 157 (46,3%) were employees, predominantly between 40 and 59 years of age among owners and under 39 among workers. Over 50% have a low level of schooling and 55.2% of them have monthly incomes less than or equal to 2 minimum wages. Many of them know about the importance of wearing personal protective equipment (PPE) and the mandatory license for the use and purchase of agrochemicals. However, about 40% do not use PPE or use it inadequately and 28.9% do not have a license to purchase. More than 9% of participants reported cases of intoxication, however, less than 7% sought specialized care. Workers are aware of the risks that the use of agrochemicals expose them to risk situations, but this does not encourage them to change their worksite behavior.

RESUMO Objetivo: comparar a geometria nasal entre dois grupos de pacientes com diferentes graus de apneia obstrutiva do sono e correlacionar índice e gravidade da apneia e grau de sonolência diurna com áreas e volume nasais. Métodos: 20 adultos (15 mulheres e 5 homens - idade média de 52,0±11,4 anos) sem obstrução nasal, submetidos à polissonografia e divididos em dois grupos: a) dez indivíduos sem ou com apneia em grau leve; b) dez com apneia moderada ou grave. A geometria nasal foi avaliada por rinometria acústica. Foram considerados o volume (distância da válvula nasal até a parte posterior da concha nasal média) e as três áreas seccionais: válvula nasal, parte anterior e parte posterior da concha nasal inferior. Foram aplicados os testes de Mann-Whitney e t de Student para amostras independentes e coeficiente de correlação de Spearman, com nível de significância de 5%. Resultados: o grupo 2 apresentou valores menores na área da válvula nasal, à direita, e maiores valores nas áreas das conchas nasais. Não houve correlação entre escala de sonolência e geometria nasal. Conclusão: a área da válvula nasal foi menor, unilateralmente, no grupo com apneia moderada e grave. Não houve correlação entre volumes e áreas nasais e sonolência diurna excessiva.

ABSTRACT Purpose: to compare nasal geometry between two groups of patients with different degrees of obstructive sleep apnea and to correlate apnea-hypopnea index, apnea severity and degree of daytime sleepiness with nasal areas and volume. Methods: a total of 20 adults (15 women and 5 men, mean age of 52.0±11.4 years old) without nasal obstruction were submitted to polysomnography. The subjects were divided into two groups: a) 10 individuals without apnea or with mild-grade apnea; b) 10 with moderate or severe apnea. Nasal geometry was evaluated by acoustic rhinometry. The volume, comprising the distance from the nasal valve to the posterior part of the middle nasal turbinate, and the three sectional areas corresponding to nasal valve, anterior part of the inferior nasal turbinate and posterior part of the inferior nasal turbinate, were considered. The Shapiro-Wilk, Mann-Whitney, Student’s t tests for independent samples and Spearman’s correlation coefficient were used for the analysis, with a significance level lower than 5%. Results: group 2 presented lower values in the area corresponding to the nasal valve (on the right), and higher values in the nasal turbinate areas. There was no correlation between the drowsiness scale and nasal areas and volumes. Conclusion: the area of the nasal valve was unilaterally smaller in the group with moderate and severe apnea. There was no correlation between volumes and nasal areas and excessive daytime sleepiness.