Synthesis, electronic, infrared, elemental micro analytical studies were carried on N-(benzothiazol-2-yl)trichloroethanamide  and N-(benzothiazol-2-yl)chloroethanamide . They were also screened in vitro and in vivo for antibacterial activity. The results indicate that the compounds are very stable and that they show high antibacterial activities against both gram-positive and gram-negative bacteria tested. Both derivatives of 2-aminobenzothiazole were active against the multiresistant bacteria with IZD ranging from 9 -18 mm  and 9 - 20mm . From the MIC results it is observed that the  derivative produced a better antibacterial activity than the  derivative. The lethal concentrations (LC50) of the compounds were also determined. Their solubilities and melting points were also determined.