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Resumo: A pandemia de COVID-19 pode ter impactado a saúde mental de estudantes universitários e, consequentemente, levado ao início ou ao aumento do uso de medicamentos psicotrópicos. Este estudo avaliou a prevalência do uso de medicamentos psicotrópicos entre estudantes universitários e avaliar a associação do uso dessa classe de medicamentos com estudantes de grupos minoritários. Trata-se de um estudo transversal, no qual todos os estudantes matriculados em cursos de graduação em oito universidades públicas brasileiras foram convidados. Dados foram coletados de outubro de 2021 a fevereiro de 2022, por meio de um questionário online autoaplicável. A variável de interesse foi o uso de medicamentos psicotrópicos e as variáveis explicativas foram estudantes pertencentes a grupos minoritários, como mulheres; negros, pardos e de outras cores de pele; e orientação sexual LGBTQIAPN+. As variáveis foram analisadas de forma descritiva, sendo realizados o teste qui-quadrado de Pearson e a regressão logística multinomial. Um total de 8.650 estudantes participaram do estudo, dos quais 25,7% relataram o uso de medicamentos psicotrópicos nos 30 dias anteriores ao preenchimento do questionário. Observou-se que, entre os estudantes, ser do sexo feminino (OR = 1,8; IC95%: 1,41-2,20) e não ser heterossexual (OR = 1,5; IC95%: 1,23-1,80) aumentaram as chances de usar medicamentos psicotrópicos durante a pandemia de COVID-19. Constatou-se que estudantes universitários iniciaram o uso de medicamentos psicotrópicos e encontrou-se associação entre esse uso e estudantes de grupos minoritários.

Resumen: La pandemia del COVID-19 puede haber afectado a la salud mental de los estudiantes universitarios y, en consecuencia, haber llevado al inicio o aumento del uso de los psicofármacos. Este estudio evaluó la prevalencia del uso de los psicofármacos entre estudiantes universitarios y examinó la asociación de este uso con estudiantes de grupos minoritarios. Se trata de un estudio transversal, en el que se invitó a todos los estudiantes matriculados en cursos de grado en ocho universidades públicas brasileñas. Los datos se recopilaron desde octubre de 2021 hasta febrero de 2022 mediante un cuestionario en línea autoadministrado. La variable de interés fue el uso de psicofármacos; y las variables explicativas fueron estudiantes pertenecientes a grupos minoritarios, como mujeres; negros, pardos u otros colores de piel; y orientación sexual LGBTQIAPN+. Las variables se analizaron de manera descriptiva y se realizaron la prueba de chi-cuadrado de Pearson y la regresión logística multinomial. Un total de 8.650 estudiantes participaron en el estudio, de los cuales el 25,7% informó haber usado los psicofármacos a los 30 días previos a completar el cuestionario. Se observó que, entre los estudiantes, ser mujer (OR = 1,8; IC95%: 1,41-2,20) y no ser heterosexual (OR = 1,5; IC95%: 1,23-1,80) aumentaron las posibilidades de uso de psicofármacos durante la pandemia del COVID-19. Se encontró que los estudiantes universitarios empezaron a usar los psicofármacos y se encontró una asociación entre este uso y los estudiantes de grupos minoritarios.

Abstract: The COVID-19 pandemic may have had an impact on the mental health of university students and, consequently, led to the initiation on psychotropic medications or an increase on its use. This study aimed to assess the prevalence of the use of psychotropic medications among university students and evaluate the association of the use of such medicine with students who belong to minority groups. This is a cross-sectional study, in which all students enrolled in undergraduate courses at eight Brazilian public universities were invited to answer an online self-administered questionnaire. The data collection was conducted from October 2021 to February 2022. The outcome was the use of psychotropic medications and the explanatory variables were students who belong to minority groups, such as female, black, mixed-race, and other skin colors, and LGBTQIAPN+ individuals. The variables were descriptively analyzed and Pearson’s chi-squared test and multinomial logistic regression were performed. A total of 8,650 students participated in the study, of which 25.7% reported using psychotropic medications in the 30 days prior to completing the questionnaire. It was observed that among students, female (OR = 1.8; 95%CI: 1.41-2.20) and non-heterosexual (OR = 1.5; 95%CI: 1.23-1.80) had higher chances of using psychotropic medications during the COVID-19 pandemic. It was found that university students began using psychotropic medications and the association of its use with minority groups was observed.

https://doi.org/10.1590/0102-311xen231323

Fear and Risk of Falling in Older Hypertensive Individuals Undergoing Medication Treatment
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Apolicena Dantas, Aelem Cristina

; Nunes Pires, Maria Luiza

; de Lima Santos, Aliny

; França Garcia, Lucas

; Andrade do Nascimento Júnior, José Roberto

; Covre da Silva, Grazieli

; Quadros da Silva, Eduardo

; Vicentini de Oliveira, Daniel

Enfermería: Cuidados Humanizados

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2025, Volume 14 N. 1 elocation e4333

Abstract: Pt Es En | Text: Pt Es En | PDF: Pt | PDF: Es | PDF: En

Resumo: Introdução: As quedas são uma preocupação importante entre os idosos hipertensos, pois podem causar lesões graves e reduzir a qualidade de vida. Compreender o impacto do uso de medicamentos anti-hipertensivos no risco de queda e no medo de cair é fundamental para melhorar o cuidado ao paciente e as estratégias de prevenção de quedas. Objetivo: Analisar os fatores associados ao risco e medo de cair em idosos hipertensos em tratamento medicamentoso. Métodos: Estudo quantitativo e transversal, realizado com 70 idosos hipertensos de um centro de especialidades médicas do município de Sapezal, Brasil. Foram aplicados o teste Timed Up and Go e a Escala de Eficácia de Quedas. Os dados foram analisados pelo teste qui-quadrado, regressão logística binária e teste de Hosmer-Lemeshow. Um nível de significância de p < 0,05 foi considerado. Resultados: Idosos que utilizam dois ou mais medicamentos anti-hipertensivos apresentam chances significativamente maiores de risco de queda (48,167 vezes) e medo de cair (15,007 vezes) em comparação com aqueles que utilizam apenas um medicamento. Além disso, aqueles que fazem uso de medicamentos por um a quatro anos e por mais de quatro anos têm 6,679 e 13,444 vezes mais chances de experimentar medo de cair com quedas recorrentes, em comparação com aqueles que os utilizam por menos de um ano. Conclusão: Há uma associação entre a quantidade e a duração do uso de medicamentos com maior risco e medo de cair em idosos hipertensos

Resumen: Introducción: Las caídas son una preocupación importante entre los adultos mayores hipertensos, ya que pueden provocar lesiones graves y una reducción en la calidad de vida. Comprender el impacto del uso de medicamentos antihipertensivos en el riesgo de caída y el miedo a caer es fundamental para mejorar la atención al paciente y las estrategias de prevención de caídas. Objetivo: Investigar las asociaciones entre el uso de medicamentos antihipertensivos y el riesgo y miedo a caer en adultos mayores hipertensos. Métodos: Estudio cuantitativo y transversal, realizado con 70 personas mayores hipertensas de un centro de especialidades médicas del municipio de Sapezal, Brasil. Se aplicaron la prueba Timed Up and Go y la Escala de Eficacia de Caídas. Los datos se analizaron mediante la prueba de chi-cuadrado, regresión logística binaria y la prueba de Hosmer-Lemeshow. Se consideró un nivel de significancia de p < 0.05. Resultados: Las personas mayores que utilizan dos o más medicamentos antihipertensivos tienen significativamente mayores probabilidades de riesgo de caída (48,167 veces) y miedo de caer (15,007 veces) en comparación con aquellas que utilizan solo un medicamento. Además, aquellas que usan medicamentos durante uno a cuatro años y más de cuatro años tienen 6,679 y 13,444 veces más probabilidades de experimentar miedo de caer con caídas recurrentes, en comparación con aquellas que los usan por menos de un año. Conclusión: Existe una asociación entre la cantidad y la duración del uso de medicamentos con un mayor riesgo y miedo de caer en personas mayores hipertensas

Abstract: Introduction: Falls are a major concern among hypertensive older adults, as they can lead to severe injuries and reduced quality of life. Understanding the impact of antihypertensive medication use on fall risk and fear of falling is essential for improving patient care and fall prevention strategies. Objective: To investigate the associations between antihypertensive medication use and the risk and fear of falling in hypertensive older adults. Methods: A quantitative and cross-sectional study was conducted with 70 hypertensive older adults from a medical specialty center in the municipality of Sapezal, Brazil. The Timed Up and Go test and the Falls Efficacy Scale were applied. Data were analyzed using the Chi-square test, binary logistic regression, and the Hosmer-Lemeshow test. A significance level of p < 0.05 was considered. Results: Older adults using two or more antihypertensive medications have significantly higher chances of fall risk (48.167 times) and fear of falling (15.007 times) compared to those using only one medication. Additionally, those taking medications for one to four years and over four years have 6.679 and 13.444 times greater chances of experiencing fear of falling with recurrent falls compared to those using them for less than one year. Conclusion: There is an association between the quantity and duration of medication use with a higher risk and fear of falling in hypertensive older adults.

https://doi.org/10.22235/ech.v14i1.4333

Clinical and epidemiological characterisation of neurofibromatosis type 1: Combined analysis of a reference hospital in Brazil and DataSUS
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Lins, Marina Gabriela da Silva

; Morais, Peterson de Jesus

; Martinho, Júlia de Oliveira

; Nascimento, Mariah Cristina Antunes do

; Vila, Ana Paula Simedan

; Castanhole-Nunes, Márcia Maria Urbanin

; Pavarino, Érika Cristina

; Goloni-Bertollo, Eny Maria

Genetics and Molecular Biology

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2025, Volume 48 N. 1 elocation e20240144

Abstract: En | Text: En | PDF: En

Abstract Neurofibromatosis type 1 (NF1) is a syndrome triggered by mutations in the NF1 gene, which alter the neurofibromin protein, a negative regulator of the RAS oncogenic pathway. Due to underreporting, the scarcity of studies on NF1 in Brazil and its importance in public health. This study aimed to assess the clinical and epidemiological characterisation of NF1 in a Reference Hospital in the country and DataSUS. The study analysed the electronic medical records of patients with NF1 and the DataSUS databases. The medical records showed a greater number of female, white and adult patients. There was a high frequency of clinical features adopted by the NIH consensus for the clinical diagnosis of the disease, such as CALMs, dermal neurofibromas and axillary/inguinal ephelides, bone and ophthalmological changes, in addition malignant and benign neoplasms and neurodevelopmental disorders. On the other hand, the data provided by DataSUS shows a disproportionate concentration of NF1 consultations between the country’s regions, with a low level of diagnoses of newborn with NF1 and a NF1 mortality rate of 3.06% in the population. There is therefore a need for new public policies on access to diagnosis, treatment and information about the disease for the Brazilian population.

https://doi.org/10.1590/1678-4685-gmb-2024-0144

Advanced maternal age and occurrence of infant death: Brazilian ecological study
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Sousa, Larissa Muzel de

; Gonçalves, Ivana Regina

; Carvalheira, Ana Paula Pinho

; Parenti, Ana Beatriz Henrique

; Nunes, Hélio Rubens de Carvalho

; Parada, Cristina Maria Garcia de Lima

Revista Gaúcha de Enfermagem

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2025, Volume 46 elocation e20240154

Abstract: En Es Pt | Text: En Es Pt | PDF: En | PDF: Es | PDF: Pt

ABSTRACT Objective: To analyze the evolution of the characteristics of infant deaths registered in Brazil among women with advanced maternal age. Method: Ecological time series study using secondary data from the Mortality Information System on the evolution of infant deaths from 2011-2020. The variables assessed included: maternal, infant gestational and birth characteristics, as well as data related to death. The behavior of the variables was assessed using simple linear regression models with a normal response, with the year as the independent variable in each of the subpopulations. Results: The studied sample consisted of 30,843 infant deaths among women aged 35 years or over. There was a decreasing trend for the variables race/white skin color, living in the southern region of the country, lack of schooling of the mother or up to 7 years education, paid work and vaginal delivery; there was an increase trend for the variables: race/brown skin color, mother’s education level equal to or greater than 8 years and low birth weight. Conclusion: The analysis revealed distinct patterns regarding sociodemographic and maternal and child health factors, highlighting the complexity of infant mortality trends and the importance of effective collective approaches.

RESUMEN Objetivo: Analizar la evolución de las características de los fallecimientos infantiles registrados en Brasil entre madres con edad materna avanzada. Método: Estudio ecológico de series temporales utilizando datos secundarios del Sistema de Información sobre Mortalidad sobre la evolución de las muertes infantiles en el período de 2011-2020. Las variables analizadas incluyeron: características maternas, infantiles, de gestación y nacimiento, así como datos relacionados con el fallecimiento. El comportamiento de las variables se evaluó mediante modelos de regresión lineal simple con respuesta normal, con el año como variable independiente en cada una de las subpoblaciones. Resultados: La muestra estudiada fue de 30.843 fallecimientos infantiles de mujeres de 35 años o más. Se observó una tendencia de disminución para las variables: raza/color blanco, residencia en la región sur del país, falta de escolaridad de la madre o hasta 7 años de escolaridad, trabajo remunerado y parto vaginal; y una tendencia de aumento para las variables: raza/color pardo, nivel de escolaridad de la madre igual o superior a 8 años y bajo peso al nacer. Conclusión: El análisis reveló patrones distintos en relación con factores sociodemográficos y de salud materno-infantil, destacando la complejidad de las tendencias de mortalidad infantil y la importancia de enfoques colectivos eficaces.

RESUMO Objetivo: Analisar a evolução das características dos óbitos infantis registrados no Brasil entre mães com idade materna avançada. Método: Estudo ecológico de séries temporais, utilizando dados secundários do Sistema de Informação de Mortalidade sobre evolução dos óbitos infantis no período de 2011 a 2020. As variáveis analisadas incluíram: características maternas, infantis, gestação e nascimento e dados relacionados ao óbito. O comportamento das variáveis foi avaliado por meio de modelos de regressão linear simples com resposta normal, com o ano como variável independente em cada uma das subpopulações. Resultados: A amostra estudada foi composta por 30.843 óbitos infantis de mulheres com 35 anos ou mais. Observou-se tendência de diminuição para as variáveis: raça/cor branca, residência na região sul do país, falta de escolaridade da mãe ou até 7 anos de escolaridade, trabalho remunerado e parto vaginal; e tendência de aumento estatisticamente significativa para as variáveis: raça/cor parda, nível de escolaridade da mãe igual ou superior a 8 anos e baixo peso ao nascer. Conclusão: A análise revelou padrões distintos em relação a fatores sociodemográficos e de saúde materno-infantil, destacando a complexidade das tendências de mortalidade infantil e a importância de abordagens coletivas eficazes.

https://doi.org/10.1590/1983-1447.2025.20240154.en

Did the COVID-19 pandemic influence the use of psychotropic medications by university students and LGBTQIAPN+? A Brazilian multicenter study
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Paula, Waléria de

; Meireles, Adriana Lúcia

; Barbosa, Bruna Carolina Rafael

; Menezes Júnior, Luiz Antônio Alves de

; Cardoso, Clareci Silva

; Ferreira, Lívia Garcia

; Freitas, Eulilian Dias de

; Vidigal, Fernanda de Carvalho

; Silva, Luciana Saraiva da

; Nobre, Luciana Neri

; Machado, Elaine Leandro

; Oliveira, Helian Nunes de

; Nascimento, Renata Cristina Rezende Macedo do

; Silva, Glenda Nicioli da

Cadernos de Saúde Pública

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2025, Volume 41 N. 3 elocation e00231323

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

https://doi.org/10.1590/0102-311xen231323

Diagnosing preclinical and clinical Alzheimer's disease with visual atrophy scales in the clinical practice
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Socher, Karen Luiza Ramos

; Nunes, Douglas Mendes

; Lopes, Deborah Cristina P.

; Coutinho, Artur Martins Novaes

; Faria, Daniele de Paula

; Squarzoni, Paula

; Busatto Filho, Geraldo

; Buchpiguel, Carlos Alberto

; Nitrini, Ricardo

; Brucki, Sonia Maria Dozzi

Arquivos de Neuro-Psiquiatria

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2025, Volume 83 N. 1 elocation s00451802960

Abstract: En | Text: En | PDF: En

ABSTRACT Background Visual atrophy scales from the medial temporal region are auxiliary biomarkers of neurodegeneration in Alzheimer's disease (AD). Therefore, they may correlate with progression from cognitively unimpaired (CU) status to mild cognitive impairment (MCI) and AD, and they become a valuable tool for diagnostic accuracy. Objective To compare the medial temporal lobe atrophy (MTA) and entorhinal cortex atrophy (ERICA) scores measured through magnetic resonance image (MRI) scans as a useful method for probable AD diagnosis regarding clinical diagnosis and amyloid positron-emission tomography (PET). Methods Two neurologists blinded to the diagnoses classified 113 older adults (age > 65 years) through the MTA and ERICA scores. We investigated the correlations involving these scores and sociodemographic data, amyloid brain cortical burden measured through PET imaging with (11)C-labeled Pittsburgh Compound-B (11C-PIB PET), and clinical cognitive status, in individuals diagnosed as CU (CU; N = 30), presenting mild cognitive impairment (MCI, N = 52), and AD patients (N = 31). Results The inter-rater reliability of the atrophy scales was excellent (0.8–1) according to the Cohen analysis. The CU group presented lower MTA scores (median value: 0) than ERICA (median value: 1) scores in both hemispheres. The 11C-PIB-PET was positive in 45% of the sample. In the MCI and AD groups, the ERICA score presented greater sensitivity, and the MTA score presented greater specificity. The accuracy of the clinical diagnosis was sufficient and no more than 70% for both scores in AD. Conclusion In the present study, we found moderate sensitivity for the ERICA score, which could be a better screening tool than the MTA score for the diagnosis of AD or MCI. However, none of the scores were useful imaging biomarkers in preclinical AD.

https://doi.org/10.1055/s-0045-1802960

Recommendations on neurologic, cognitive, and psychiatric manifestations in patients with Sjögren’s disease by the Brazilian Society of Rheumatology
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Oliveira, Fabiola Reis de

; Appenzeller, Simone

; Pasoto, Sandra Gofinet

; Fernandes, Marilena Leal Mesquita Silvestre

; Lopes, Maria Lucia Lemos

; Fialho, Sonia Cristina de Magalhães Souza

; Pinheiro, Aysa Cesar

; Santos, Laura Caldas dos

; Valim, Valeria

; Serrano, Erica Vieira

; Ribeiro, Sandra Lucia Euzébio

; Libório-Kimura, Tatiana Nayara

; Egypto, Danielle Christinne Soares do

; Cantali, Diego Ustárroz

; Gennari, Juliana D’Agostino

; Miyamoto, Samira Tatiyama

; Capobianco, Karina Gatz

; Pugliesi, Alisson Aliel Vigano

; Civile, Vinicius Tassoni

; Pinto, Ana Carolina Pereira Nunes

; Rocha-Filho, César Ramos

; Rocha, Aline Pereira da

; Trevisani, Virginia Fernandes Moça

Advances in Rheumatology

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2025, Volume 65 elocation 7

Abstract: En | Text: En | PDF: En

Abstract Background Neurological and psychiatric manifestations occur in patients with primary Sjögren’s disease (SjD) with a wide-ranging clinical presentation, affecting quality of life, social participation, and prognosis. Despite this, neither central nor peripheral neurological symptoms are systematically evaluated in the context of autoimmunity or identified as manifestations of SjD. The EULAR Sjögren’s Syndrome Disease Activity Index (ESSDAI) covers only part of them in the neurological domain. Methods We performed a systematic review of the diagnosis and prevalence of central, peripheral, and autonomic nervous system manifestations in primary SjD, following the recommendations proposed by the Cochrane Collaboration Handbook. Observational studies were included when their main issue was the diagnosis and the prevalence of the manifestations individually. We employed a generalized linear mixed model (GLMM) method with a random-effects model, and the results were computed using logit transformation, implemented through the ‘meta’ and ‘metafor’ packages in the R software (version 3.6.1). To present these recommendations, agreement among experts was investigated using the Delphi method in in-person meetings. Results We propose ten recommendations regarding the investigation and management of neurological involvement in SjD that had 100% agreement among participants. Conclusion These recommendations add to the literature on the clinical care of patients with SjD.

https://doi.org/10.1186/s42358-025-00438-7

Immediate effects of photobiomodulation with low-level laser in women with no laryngeal or voice changes: preliminary results
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Bacelete, Viviane Souza Bicalho

; Plec, Elisa Meiti Ribeiro Lin

; Nunes, Flávio Barbosa

; Motta, Andréa Rodrigues

; Gama, Ana Cristina Côrtes

CoDAS

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2025, Volume 37 N. 3 elocation e20240222

Abstract: En | Text: En | PDF: En

ABSTRACT Purpose To assess the safety and immediate effect of photobiomodulation of low-level laser in vocally healthy women. Methods Experimental research in 36 vocally healthy women aged 18 to 45 years, with skin phototype I to III and body mass index below 25. Participants were randomized to form four groups: Group 1: placebo laser photobiomodulation followed by voiced tongue trill technique (VTTT); Group 2: 3 J infrared laser per point (total 21 J) followed by VTTT; Group: 3: 6 J infrared laser per point (total 42 J) followed by VTTT; and Group 4: 9 J infrared laser per point (total 63 J) followed by VTTT. The following outcomes were assessed: auditory-perceptual evaluation, acoustic analysis (jitter, shimmer, amplitude perturbation quotient [APQ], noise-to-harmonic ratio, period perturbation quotient, cepstral peak prominence, and cepstral peak prominence smoothed), and self-perceived phonatory effort. All participants’ records were taken before and immediately after the experiments. Results There was no significant difference in voice quality, acoustic parameters, or self-perceived phonatory discomfort between intervention moments in the placebo, VTTT + 3 J, and VTTT + 6 J groups in the intragroup comparison. G4 (VTTT + 9 J) decreased shimmer and APQ aperiodicity measures (respective p-values: 0.033; 0.044). Conclusion Results indicate aperiodicity measures improved with VTTT preceded by 9 J low-level laser application per point, commending this irradiation dosimetry as a possible energy for voice therapy in light-skinned and normal-BMI women. There was no evidence of worsened measures or in-creased discomfort with this resource, indicating it is safe for clinical practice.

https://doi.org/10.1590/2317-1782/e20240222en

Analysis of content, credibility, and reliability of information on chronic obstructive pulmonary disease treatment in YouTube™ videos: a cross-sectional observational study
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Rodrigues, Ana Luíza da Silva Nunes Teixeira

; Lage, Vanessa Kelly da Silva

; Taiar, Redha

; Santos, Joyce Noelly Vitor

; Maia, Laisa Braga

; Santos, Jousielle Márcia dos

; Oliveira, Vinícius Cunha

; Lacerda, Ana Cristina Rodrigues

; Mendonça, Vanessa Amaral

Fisioterapia e Pesquisa

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2025, Volume 32 elocation e23017924en

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

RESUMO A Doença Pulmonar Obstrutiva Crônica (DPOC) é caracterizada por anormalidades das vias aéreas, resultando em obstrução persistente do fluxo aéreo. O tratamento dessa doença envolve intervenções apoiadas por vários consensos e diretrizes sobre DPOC. O YouTube pode muitas vezes ser utilizado para partilhar informações sobre o tratamento de doenças crônicas, no entanto a credibilidade dessa informação pode não ser adequada. Este estudo tem como objetivo avaliar a confiabilidade e credibilidade das informações relativas ao tratamento da DPOC no YouTube, a plataforma de mídia social mais popular, e avaliar seu alinhamento com a diretriz GOLD. Foi realizado um estudo observacional transversal, envolvendo a seleção dos primeiros 200 vídeos em inglês sobre tratamento da DPOC postados no YouTube. Os vídeos foram avaliados por meio de instrumentos validados, incluindo a ferramenta Discern (para avaliação de qualidade), o Health on the Net Foundation Code of Conduct – HONcode (para avaliação de credibilidade) e a diretriz GOLD (como referência). Os vídeos demonstraram baixa concordância com a diretriz GOLD (97,4%). Em relação à credibilidade, 75,7% dos vídeos obtiveram alto índice de credibilidade de acordo com a avaliação do HONcode. Quanto à qualidade da informação, 75,7% dos vídeos receberam avaliação positiva com base na ferramenta Discern. Os vídeos analisados apresentaram boa credibilidade, mas níveis variados de qualidade, variando de médio à baixo. Além disso, houve concordância limitada entre os vídeos e a diretriz GOLD. A análise contínua de tal conteúdo pode ser utilizada para garantir o fornecimento de informações confiáveis no YouTube.

ABSTRACT Chronic Obstructive Pulmonary Disease (COPD) is characterized by airway abnormalities, resulting in persistent airflow obstruction. Treatment involves pharmacological and nonpharmacological interventions which are supported by several COPD consensus and guidelines. YouTube can often be used to share information about treatments for chronic diseases like COPD; however, the credibility of such information may not be adequate. This study evaluates the reliability and credibility of information concerning COPD treatment disseminated on YouTube, the most popular social media platform, and assess its alignment with the GOLD guideline. A cross-sectional observational study was conducted to select the first 200 English-language videos on COPD treatment posted on YouTube. Video evaluation used validated instruments, including the DISCERN tool (quality assessment), the Health on the Net Foundation Code of Conduct - HONcode (credibility assessment), and the GOLD guideline (reference). Poor agreement with the GOLD guideline (97.4%) was found. HONcode assessment showed that 75.7% of the videos achieved a high credibility rating. Regarding information quality, 75.7% of the videos received positive ratings based on the DISCERN tool. Despite exhibiting adequate credibility, the analyzed videos displayed fluctuating levels of quality, ranging from medium to low. Moreover, there was limited consensus between the videos and the GOLD guideline. Continuous analysis of such content can be used to ensure dissemination of reliable information on YouTube.

RESUMEN La enfermedad pulmonar obstructiva crónica (EPOC) se caracteriza por anomalías en las vías respiratorias que ocasionan una obstrucción persistente del flujo aéreo. El tratamiento de esta enfermedad implica intervenciones respaldadas por diversos consensos y guías sobre la EPOC. Aunque suelen utilizar YouTube para compartir información sobre el tratamiento de enfermedades crónicas como la EPOC, la credibilidad de esta información puede no ser adecuada. Este estudio tiene como objetivo evaluar la fiabilidad y la credibilidad de la información sobre el tratamiento de la EPOC en YouTube, una de las redes sociales más populares, y evaluar su alineación con la guía GOLD. Se realizó un estudio observacional transversal, que incluyó la selección de los primeros 200 vídeos en inglés, publicados en YouTube sobre el tratamiento de la EPOC. Los vídeos se evaluaron mediante instrumentos validados, como la herramienta Discern (para la evaluación de la calidad), el Código de Conducta HONcode (para la evaluación de la credibilidad) y la guía GOLD (como referencia). Los vídeos presentaron una baja concordancia con la guía GOLD (97,4%). En cuanto a la credibilidad, el 75,7% de los vídeos obtuvieron un alto índice de credibilidad según la evaluación de HONcode. En cuanto a la calidad de la información, el 75,7% de los vídeos recibieron una evaluación positiva basada en la herramienta Discern. Los vídeos evaluados tuvieron buena credibilidad, pero variados niveles de calidad, que van de mediano a bajo. Además, hubo un consenso limitado entre los vídeos y la guía GOLD. El análisis continuo de este tipo de contenido se puede utilizar para garantizar información confiable en YouTube.

https://doi.org/10.1590/1809-2950/e23017924en

10.

Espaços de lazer de natureza e iniquidade racial
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Nunes, Danilo Ciaco

; Silvestre, Bruno Modesto

; Amaral, Silvia Cristina Franco

Revista Brasileira de Estudos Urbanos e Regionais

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2025, Volume 27 elocation e202509

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Este estudo teve por objetivo analisar o acesso da população negra de Campinas, com base na distância de moradia, aos equipamentos públicos de lazer na natureza instalados na cidade. Foram utilizados dados oficiais fornecidos pelo município e aqueles relativos ao georreferenciamento da distribuição das Áreas Verdes de Função Social cotejados com os dados raciais do Censo 2010. Por meio do acompanhamento da evolução da morfologia urbana e do aumento do perímetro oficial da cidade, ocorrido como resultado de movimentos migratórios regulares, os quais trouxeram pessoas em busca de melhores condições de vida (em sua maioria negras), conclui-se que Campinas reproduz um modelo de urbanização dispersa, que impacta o acesso aos espaços públicos de lazer já precarizados desde o processo da abolição escravagista.

Abstract This study aimed to analyze the access of the black population of Campinas, based on residential distance, to public leisure facilities in nature in the city. To do so, it uses official data provided by the municipality and georeferencing of the distribution of Social Function Green Areas use juxtaposed with racial data from the 2010 census. Following the evolution of urban morphology and the expansion of the city’s perimeter, which occurred through regular migratory movements bringing people in search of better living conditions (mostly black), it is possible to conclude that the city of Campinas reproduces a dispersed model of urbanization, impacting access to already precarious public leisure spaces since the abolition of slavery.

https://doi.org/10.22296/2317-1529.rbeur.202509

11.

The phenotype of monocyte subtypes and expression of chemokine receptors in the Chronic Venous Insufficiency
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Germano, Danielle Borges

; Chiba, Larissa Namie

; Ballerini, Ana Paula Augusto da Cruz

; Amaral, Jônatas Bussador do

; Shio, Marina Tiemi

; Alves, Jhefferson Miranda

; Abreu, Daniela Alves de

; Nali, Luiz Henrique da Silva

; Fonseca, Francisco Antonio Helfenstein

; Izar, Maria Cristina

; Bachi, André Luis Lacerda

; França, Carolina Nunes

Clinics

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2025, Volume 80 elocation 100595

Abstract: En | Text: En | PDF: En

ABSTRACT Objective: The aim of this study was to evaluate monocyte subtypes and the chemokine receptors, comparing individuals with and without Chronic Venous Insufficiency (CVI). Method: The authors included patients undergoing surgery for varicose veins of the lower limbs (Classification of Venous Disorders - CEAP: C1-C3). Results: There were increased levels of classical and non-classical monocytes in the case group and a reduction in intermediate monocytes. Besides, there was higher expression of CCR5 in the non-classical monocytes and lower expression of CX3CR1 in the classical monocytes in the case group. Conclusions: The inflammatory process present in patients with CVI can modulate the monocyte phenotype and the expression of the chemokine receptors at the protein level.

https://doi.org/10.1016/j.clinsp.2025.100595

12.

Polifarmácia associada a baixa capacidade funcional em pessoas idosas: resultados do estudo SHIP-Brazil
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Santos, Ana Beatriz dos

; Trindade, Mônica Cristina Nunes de

; Nilson, Luana Gabriele

; Sousa, Clóvis Arlindo de

; Markus, Marcello Ricardo Paulista

; Helena, Ernani Tiaraju de Santa

Revista Brasileira de Geriatria e Gerontologia

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2025, Volume 28 elocation e240098

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Objetivo Investigar a associação entre a polifarmácia e baixa capacidade funcional entre pessoas idosas, residentes no sul do Brasil. Método Estudo do tipo observacional seccional realizado com 511 pessoas idosas participantes do estudo “Vida e Saúde em Pomerode-SHIP Brazil”. Uma entrevista com questionário estruturado foi realizada, contendo variáveis sociodemográficas, comportamentais, condições gerais, de saúde e assistenciais. A capacidade funcional foi estimada em escala de zero a 100 e quartis com base no questionário SF-36. A associação entre a polifarmácia (cinco medicamentos ou mais) e baixa capacidade funcional (quartil 25 ou menos) foi estimada por regressão logística. Resultado: Dentre os participantes, 48,3% utilizavam 5 ou mais medicamentos. A mediana da capacidade funcional foi de Conclusão Há uma associação entre polifarmácia e baixa capacidade funcional, mesmo após ajuste por fatores socioeconômicos, de estilo de vida, condições gerais, de saúde e assistenciais. Faz-se necessário implementar ações de promoção a saúde direcionadas à população de 60 anos ou mais que utilizam medicamentos, de modo a garantir tratamento efetivo, seguro e que evite a baixa capacidade funcional.

Abstract Objective To investigate the association between polypharmacy and low functional capacity among older adults residing in southern Brazil. Method This cross-sectional observational study involved 511 older adults participating in the Study of Health in Pomerode (SHIP-Brazil) study. A structured questionnaire interview was conducted, including sociodemographic, behavioral, general health, and healthcare variables. Functional capacity was assessed using a 0-to-100 scale and quartiles based on the SF- 36 questionnaire. The association between polypharmacy (five or more medications) and low functional capacity (25th percentile or lower) was estimated using logistic regression. Results Among the participants, 48.3% used five or more medications. The median functional capacity was 65 (IQR 40–85). A negative correlation was observed between the functional capacity scale and the number of medications (rho = -0.3068; p > 0.001). The likelihood of having low functional capacity was 2.8 times higher (95% CI 1.8–4.1) among those consuming five or more medications compared to those consuming four or fewer. This association remained significant across all adjusted models, with the greatest reductions observed for clinical (OR = 1.6; 95% CI 1.1–2.6) and healthcare-related variables (OR = 1.8; 95% CI 1.2–2.9). Conclusion There is an association between polypharmacy and low functional capacity, even after adjusting for socioeconomic, lifestyle, general health, and healthcare-related factors. It is essential to implement health promotion actions targeted at the population aged 60 years or older who use medications, ensuring effective and safe treatment while preventing low functional capacity.

https://doi.org/10.1590/1981-22562025028.240098.pt

13.

Impact of prognostic scores on acute kidney injury assessment in the postoperative period of myocardial revascularization
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Reis, Abraão Alves dos

; Duarte, Tayse Tâmara da Paixão

; Ipolito, Michelle Zampieri

; Silva, Kamilla Grasielle Nunes da

; Magro, Paulo Percio Mota

; Silva Magro, Marcia Cristina da

Revista da Escola de Enfermagem da USP

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2025, Volume 59 elocation e20240410

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

RESUMO Objetivo: Determinar o impacto do Simplified Acute Physiology Score 3 e do Sequential Organ Failure Assessment na avaliação da gravidade de pacientes com injúria renal aguda no pós-operatório de revascularização do miocárdio com circulação extracorpórea. Método: Estudo de coorte retrospectiva, com amostra não probabilística. Realizou-se análise inferencial com testes qui-quadrado de Pearson, exato de Fisher e Mann-Whitney, com nível de significância de 5%. Resultados: A prevalência de injúria renal aguda foi de 31,4%. O Simplified Acute Physiology Score 3 e o Sequential Organ Failure Assessment apresentaram pontuações maiores nos pacientes com injúria renal (58 (48–64) versus 48 (37–57), p = 0,02; 7 (6–9) versus 6 (5–7), p = 0,003), além de maior tempo de permanência na terapia intensiva, de 8 (6–16) versus 6 (5–8) (p = 0,02) dias, respectivamente. Conclusão: Pacientes com injúria renal aguda permaneceram mais tempo na terapia intensiva, e o Simplified Acute Physiology Score 3 e o Sequential Organ Failure Assessment mostraram bom desempenho, evidenciando maior gravidade entre os pacientes com injúria renal aguda no pós-operatório de cirurgia de revascularização do miocárdio.

ABSTRACT Objective: To determine the impact of the Simplified Acute Physiology Score 3 and the Sequential Organ Failure Assessment in assessing the severity of acute kidney injury in patients after cardiopulmonary bypass. Method: A retrospective cohort study with a non-probabilistic sample. Inferential analysis was performed using Pearson’s chi-square, Fisher’s exact and Mann-Whitney tests, with a significance level of 5%. Results: The prevalence of acute kidney injury was 31.4%. The Simplified Acute Physiology Score 3 and the Sequential Organ Failure Assessment showed higher scores in patients with kidney injury (58 (48–64) versus 48 (37–57), p = 0.02; 7 (6–9) versus 6 (5–7), p = 0.003), in addition to a longer stay in intensive care, 8 (6–16) versus 6 (5–8) (p = 0.02) days, respectively. Conclusion: Patients with acute kidney injury remained in intensive care longer, and the Simplified Acute Physiology Score 3 and the Sequential Organ Failure Assessment showed good performance, evidencing greater severity among patients with acute kidney injury in the postoperative period of coronary artery bypass grafting.

RESUMEN Objetivo: Determinar el impacto del Simplified Acute Physiology Score 3 y el Sequential Organ Failure Assessment en la evaluación de la gravedad de pacientes con lesión renal aguda en el postoperatorio de revascularización miocárdica con circulación extracorpórea. Método: Estudio de cohorte retrospectivo, con muestra no probabilística. El análisis inferencial se realizó mediante las pruebas chi-cuadrado de Pearson, exacta de Fisher y Mann-Whitney, con un nivel de significancia del 5%. Resultados: La prevalencia de lesión renal aguda fue del 31,4%. El Simplified Acute Physiology Score 3 y el Sequential Organ Failure Assessment mostraron puntuaciones más altas en pacientes con lesión renal (58 (48–64) versus 48 (37–57), p = 0,02; 7 (6–9) versus 6 (5–7), p = 0,003), además de una estancia más prolongada en cuidados intensivos, 8 (6–16) versus 6 (5–8) (p = 0,02) días, respectivamente. Conclusión: Los pacientes con lesión renal aguda permanecieron más tiempo en cuidados intensivos, y el Simplified Acute Physiology Score 3 y el Sequential Organ Failure Assessment mostraron buen desempeño, mostrando mayor gravedad entre los pacientes con lesión renal aguda en el postoperatorio de la cirugía de revascularización miocárdica.

https://doi.org/10.1590/1980-220x-reeusp-2024-0410en

14.

Medication-related osteonecrosis of the jaws: a series of 22 cases highlighting their histopathological features
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SANTANA, Dandara Andrade de

; BASTOS, Yann Victor Paiva

; OLIVEIRA, Paulo Tambasco de

; PIRES, Bruno Cunha

; XAVIER, Flávia Caló Aquino

; LEITÃO, Águida Cristina Gomes Henriques

; COUTO, Larissa Abbehusen

; SOUZA, André Sampaio

; RAMALHO, Luciana Maria Pedreira

; CURY, Patrícia Ramos

; SANTOS, Jean Nunes dos

Brazilian Oral Research

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2025, Volume 39 elocation e058

Abstract: En | Text: En | PDF: En

Abstract This study aimed to assess the clinicopathological characteristics of medication-related osteonecrosis of the jaw (MRONJ), addressing histopathological features and bone structure. Twenty-two MRONJ patients were retrospectively evaluated for osteonecrosis, osteomyelitis, bacterial colonization, bone resorption, reactive bone, osteon-like structure, lamellar bone, and basophilic lines. Specific staining and fluorescence and polarized light microscopy assessments were also performed. The mandible was significantly more affected by MRONJ. There was a predominance of African-Brazilian women aged sixty and older. Osteomyelitis was present in 82% of patients. Actinomycosis was observed in 36.4% of MRONJ patients. Osteoclasts were absent in MRONJ but bone resorption was often seen. Basophilic lines were observed in more than 80% of the patients. The MRONJ patients exhibited lamellar bone with osteon-like structures. This study provided important insight into MRONJ, demonstrating a diverse histopathological spectrum and infection with Actinomyces and fungi. The condition was characterized by a necrotized lamellar bone structure and more frequently affected the mandible of older women.

https://doi.org/10.1590/1807-3107bor-2025.vol39.058

15.

Sobrevivência a Longo Prazo após Transplante Ortotópico de Fígado: Análise de 20 anos em um Centro de Transplante em Campinas, Brasil
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Ivano, Victor Kenzo

; Jucá, Rafaela Hamada

; Martins Neto, Arthur Nunes

; Kreve, Fernanda

; Diniz, Tiago

; Foratto, Alexandre

; Munhoz, Derli Conceição

; Riccetto, Eduardo

; Alves, Caique Fernandes

; Perales, Simone Reges

; Ataide, Elaine Cristina

; Boin, Ilka de Fátima Santana F.

Brazilian Journal of Transplantation

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2025, Volume 28 elocation e1725

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Introdução: O transplante ortotópico de fígado (TOF) é a principal terapia para doença hepática terminal. No Brasil, a realização de transplantes aumentou significativamente nas últimas décadas, com melhorias nos desfechos a longo prazo. Este estudo analisa a sobrevida de pacientes submetidos a TOF ao longo de 20 anos em um centro de referência. Métodos: Foram revisados os prontuários de 848 pacientes transplantados entre fevereiro de 1995 e dezembro de 2017. Aplicaram-se critérios de exclusão, incluindo pacientes com sobrevida inferior a 6 meses, visando minimizar o impacto de complicações precoces no desfecho de longo prazo. Dessa forma, 174 pacientes foram incluídos. As variáveis analisadas envolveram dados do receptor, doador, enxerto, procedimento cirúrgico e evolução pós-operatória. A sobrevida foi avaliada por Kaplan–Meier. Resultados: Dos 174 pacientes analisados, 98 (56,3%) mantiveram seguimento ambulatorial e 76 (43,7%) evoluíram a óbito. A média de idade no transplante foi de 47 anos, e 75% dos receptores eram do sexo masculino. As principais indicações foram hepatite viral (59,8%) e carcinoma hepatocelular (11,6%). A média do escore MELD foi 18. A principal causa de morte foi evento cardiovascular (36,4%), seguido de recidiva da doença hepática (22,1%) e neoplasias (15,6%). O tempo médio de sobrevida foi de 223 meses entre os pacientes vivos e 112 meses entre os óbitos (p < 0,0001). Maior tempo de isquemia fria, insuficiência renal pós-operatória, diabetes e maior tempo de internação em UTI foram fatores associados a pior sobrevida. Pacientes mais jovens apresentaram sobrevida significativamente superior (p = 0,00007). Conclusão: A análise de 20 anos mostrou que o TOF apresenta boa sobrevida a longo prazo, mas fatores como diabetes, disfunção renal e tempo prolongado de isquemia fria impactam negativamente os desfechos. Eventos cardiovasculares e recidiva da doença hepática foram as principais causas de mortalidade.

ABSTRACT Introduction: Orthotopic liver transplantation (OLT) is the primary therapy for end-stage liver disease. In Brazil, the number of liver transplants has significantly increased over the past decades, improving long-term outcomes. This study analyzes the long-term survival of patients who underwent OLT over 20 years at a reference transplant center. Methods: Medical records of 848 patients who underwent OLT between February 1995 and December 2017 were reviewed. Exclusion criteria included patients with survival below six months to minimize the impact of early postoperative complications on long-term outcomes. Thus, 174 patients were included. The analyzed variables involved the recipient, donor, graft, surgical procedure, and postoperative evolution. Survival was assessed using Kaplan–Meier analysis. Results: Among the 174 analyzed patients, 98 (56.3%) remained in outpatient follow-up, while 76 (43.7%) died. The mean age at transplantation was 47 years, and 75% of recipients were male. The main indications were viral hepatitis (59.8%) and hepatocellular carcinoma (11.6%). The mean MELD score was 18. The leading cause of death was cardiovascular events (36.4%), followed by liver disease recurrence (22.1%) and malignancies (15.6%). The mean survival time was 223 months for surviving patients and 112 months for deceased patients (p 0.0001). Longer cold ischemia time, postoperative renal dysfunction, diabetes, and prolonged stay in the intensive care unit were associated with worse survival. Younger patients had significantly longer survival (p = 0.00007). Conclusion: The 20-year analysis demonstrated that OLT provides good long-term survival; however, factors such as diabetes, renal dysfunction, and prolonged cold ischemia time negatively impact the outcomes. Cardiovascular events and recurrence of liver disease were the leading causes of mortality.

https://doi.org/10.53855/bjt.v28i1.633_port

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