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1.
Comparison of Normal, Logistic, Laplace, and Student’s t distributions for experimental error in the Bayesian description of dry matter accumulation in Allium sativum Normal Logistic Laplace Students Student s
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Moura, George Lucas Santana de
; Guzzo, Felipe
; Cecon, Paulo Roberto
; Martins Filho, Sebastião
; Carneiro, Antônio Policarpo Souza
; Nascimento, Moysés
.
ABSTRACT: This study assessed distributions associated with Bayesian nonlinear modeling error in the description of total plant dry matteraccumulation (TDMA) of Allium sativumas a function of days after planting (DAP). According to the DIC criterion, Logistic and Gompertzmodels that use student’s t distribution error exhibited the highest DIC with logistic error distribution. In general, the difference of DIC in all the scenarios was not more than 5.The Bayes factor (BF) criterion showed no difference in the Logistic and Gompertzmodel fit when four distributions are used for the errors, where BF values do not exceed 2. Posterior distributions and the usual estimators of Logistic and Gompertz model parameters were similar even forvaried error distribution. In summary, there was no difference in the use of 4 distributions associated with the modeling error of garlic plant growth by the Bayes factor, whereby the results showed that alternating between error distributions significantly changes the number of Markov Chain Monte Carlo (MCMC) iterations. ABSTRACT TDMA (TDMA DAP. DAP . (DAP) students student s general 5The The 5 (BF errors 2 summary MCMC (MCMC iterations (DAP
RESUMO: O objetivo deste trabalho foi avaliar algumas distribuições associadas ao erro na modelagem não linear bayesiana na descrição do acúmulo de matéria seca total da planta (MSTP) de Allium sativum em função dos dias após o plantio (DAP). Pelo critério DIC os modelos Logístico e Gompertz que utilizam a distribuição do erro t de Student apresentaram a melhor qualidade de ajuste, sendo que o modelo Logístico apresentou o maior DIC com a distribuição de erro Logística. No geral, a diferença de DIC em todos os cenários não apresentou valores superiores a cinco. Pelo critério do Fator de Bayes (FB), não houve diferença no ajuste do modelo Logístico e Gompertz quando se utilizam as quatro distribuições para os erros, sendo que os valores de FB não superaram 2. As distribuições a posteriori e os estimadores usuais dos parâmetros dos modelos Logístico e Gompertz apresentaram semelhanças mesmo variando a distribuição do erro. Em suma não houve diferença na utilização das quatro distribuições associadas ao erro na modelagem do crescimento planta de alho pelo fator de Bayes, sendo que os resultados mostram que alternar entre as distribuições dos erros altera de forma significativa o número de iterações de MCMC. RESUMO MSTP (MSTP DAP. DAP . (DAP) Logística geral cinco FB, , (FB) 2 MCMC (DAP (FB
2.
miRNAs and NFKB1 and TRAF6 target genes: The initial functional study in CD14+ monocytes in rheumatoid arthritis patients NFKB TRAF genes CD14 CD CD1
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Silva, Isaura Isabelle Fonseca Gomes da
; Nascimento, Denise de Queiroga
; Barbosa, Alexandre Domingues
; Souto, Fabricio Oliveira
; Maia, Maria de Mascena Diniz
; Crovella, Sergio
; Souza, Paulo Roberto Eleuterio de
; Sandrin-Garcia, Paula
.
Abstract We predicted miRNAs with regulatory impact on NFKB1 and TRAF6 gene expression and selected the miR-194-5p, miR-124-3p, miR-9-5p, and miR-340-5p and their target genes for expression analyses on CD14+ monocytes from rheumatoid arthritis (RA) patients and healthy controls. Additionally, we evaluated the influence of genes and miRNA expression on RA patients’ cytokine levels. No difference was observed in genes or miRNAs expression when compared to healthy controls and RA patients or clinical parameters. However, we found a significant difference between miR-194-5p and miR-9-5p levels (FC=-2.31; p=0.031; FC=-3.05;p=0.031, respectively) and non-prednisone users as compared to prednisone using patients. We conducted correlation analyses to identify the strength of the relationship between expression data and cytokine plasma levels. We observed a moderate positive correlation between miR-124-3p expression and IL-6 plasma levels (r=0.46; p=0.033). In addition, overexpression of miRNAs was concomitant to TRAF6 and NFKB1 genes as indicated by correlation analyses: TRAF6 and miR-194-5p (r=0.60;p<0.001) and miR-9-5p (r=0.63;p<0.001) and NFKB1 and miR-194-5p (r=0.72;p<0.001), miR-9-5p (r=0.72;p<0.001) and miR-340-5p (r=0.61;p<0.001). NFKB1 and TRAF6 genes and miRNAs monocyte expression do not appear to be related to RA but showed a significant difference in different groups of RA therapy. In addition, increased levels of miRNAs can be linked to concomitant overexpression of TRAF6 and NFKB1 in monocytes and act as its regulators. NFKB TRAF miR1945p, miR1945p miRp miR 194 5p, 5p p miR1243p, miR1243p 124 3p, 3p miR95p, miR95p 9 miR3405p 340 CD14 CD (RA Additionally parameters However FC=2.31 FC231 FC FC= 2.31 2 31 (FC=-2.31 p=0.031 p0031 0 031 FC=3.05p=0.031, FC305p0031 FCp 3.05 p=0.031, 3 05 FC=-3.05;p=0.031 respectively nonprednisone non IL6 IL 6 IL- r=0.46 r046 r 46 (r=0.46 p=0.033. p0033 p=0.033 . 033 p=0.033) addition r=0.60p<0.001 r060p0001 rp r=0.60 p<0.001 60 001 (r=0.60;p<0.001 r=0.63p<0.001 r063p0001 r=0.63 63 (r=0.63;p<0.001 r=0.72p<0.001, r072p0001 r=0.72 , 72 r=0.72p<0.001 (r=0.72;p<0.001 r=0.61p<0.001. r061p0001 r=0.61 61 (r=0.61;p<0.001) therapy regulators 19 12 34 CD1 FC=2.3 FC23 231 2.3 (FC=-2.3 p=0.03 p003 03 05p FC=3.05p=0.031 FC305p003 305 3.0 FC=-3.05;p=0.03 r=0.4 r04 4 (r=0.4 60p r=0.60p<0.00 r060p000 r060 r=0.6 p0001 p<0.00 00 (r=0.60;p<0.00 63p r=0.63p<0.00 r063p000 r063 (r=0.63;p<0.00 72p r072p000 r072 r=0.7 7 r=0.72p<0.00 (r=0.72;p<0.00 61p r=0.61p<0.001 r061p000 r061 (r=0.61;p<0.001 1 FC=2. FC2 23 2. (FC=-2. p=0.0 p00 FC=3.05p=0.03 FC305p00 30 3. FC=-3.05;p=0.0 r=0. r0 (r=0. r=0.60p<0.0 r060p00 r06 p000 p<0.0 (r=0.60;p<0.0 r=0.63p<0.0 r063p00 (r=0.63;p<0.0 r072p00 r07 r=0.72p<0.0 (r=0.72;p<0.0 r=0.61p<0.00 r061p00 (r=0.61;p<0.00 FC=2 (FC=-2 p=0. p0 FC=3.05p=0.0 FC305p0 FC=-3.05;p=0. r=0 (r=0 r=0.60p<0. r060p0 p<0. (r=0.60;p<0. r=0.63p<0. r063p0 (r=0.63;p<0. r072p0 r=0.72p<0. (r=0.72;p<0. r=0.61p<0.0 r061p0 (r=0.61;p<0.0 (FC=- p=0 FC=3.05p=0. FC305p FC=-3.05;p=0 r= (r= r=0.60p<0 r060p p<0 (r=0.60;p<0 r=0.63p<0 r063p (r=0.63;p<0 r072p r=0.72p<0 (r=0.72;p<0 r=0.61p<0. r061p (r=0.61;p<0. (FC= p= FC=3.05p=0 FC=-3.05;p= (r r=0.60p< p< (r=0.60;p< r=0.63p< (r=0.63;p< r=0.72p< (r=0.72;p< r=0.61p<0 (r=0.61;p<0 (FC FC=3.05p= FC=-3.05;p r=0.60p (r=0.60;p r=0.63p (r=0.63;p r=0.72p (r=0.72;p r=0.61p< (r=0.61;p< FC=3.05p r=0.61p (r=0.61;p
3.
Catálogo Taxonômico da Fauna do Brasil: Setting the baseline knowledge on the animal diversity in Brazil Brasil
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Boeger, Walter A.
; Valim, Michel P.
; Zaher, Hussam
; Rafael, José A.
; Forzza, Rafaela C.
; Percequillo, Alexandre R.
; Serejo, Cristiana S.
; Garraffoni, André R.S.
; Santos, Adalberto J.
; Slipinski, Adam
; Linzmeier, Adelita M.
; Calor, Adolfo R.
; Garda, Adrian A.
; Kury, Adriano B.
; Fernandes, Agatha C.S.
; Agudo-Padrón, Aisur I.
; Akama, Alberto
; Silva Neto, Alberto M. da
; Burbano, Alejandro L.
; Menezes, Aleksandra
; Pereira-Colavite, Alessandre
; Anichtchenko, Alexander
; Lees, Alexander C.
; Bezerra, Alexandra M.R.
; Domahovski, Alexandre C.
; Pimenta, Alexandre D.
; Aleixo, Alexandre L.P.
; Marceniuk, Alexandre P.
; Paula, Alexandre S. de
; Somavilla, Alexandre
; Specht, Alexandre
; Camargo, Alexssandro
; Newton, Alfred F.
; Silva, Aline A.S. da
; Santos, Aline B. dos
; Tassi, Aline D.
; Aragão, Allan C.
; Santos, Allan P.M.
; Migotto, Alvaro E.
; Mendes, Amanda C.
; Cunha, Amanda
; Chagas Júnior, Amazonas
; Sousa, Ana A.T. de
; Pavan, Ana C.
; Almeida, Ana C.S.
; Peronti, Ana L.B.G.
; Henriques-Oliveira, Ana L.
; Prudente, Ana L.
; Tourinho, Ana L.
; Pes, Ana M.O.
; Carmignotto, Ana P.
; Wengrat, Ana P.G. da Silva
; Dornellas, Ana P.S.
; Molin, Anamaria Dal
; Puker, Anderson
; Morandini, André C.
; Ferreira, André da S.
; Martins, André L.
; Esteves, André M.
; Fernandes, André S.
; Roza, André S.
; Köhler, Andreas
; Paladini, Andressa
; Andrade, Andrey J. de
; Pinto, Ângelo P.
; Salles, Anna C. de A.
; Gondim, Anne I.
; Amaral, Antonia C.Z.
; Rondón, Antonio A.A.
; Brescovit, Antonio
; Lofego, Antônio C.
; Marques, Antonio C.
; Macedo, Antonio
; Andriolo, Artur
; Henriques, Augusto L.
; Ferreira Júnior, Augusto L.
; Lima, Aurino F. de
; Barros, Ávyla R. de A.
; Brito, Ayrton do R.
; Romera, Bárbara L.V.
; Vasconcelos, Beatriz M.C. de
; Frable, Benjamin W.
; Santos, Bernardo F.
; Ferraz, Bernardo R.
; Rosa, Brunno B.
; Sampaio, Brunno H.L.
; Bellini, Bruno C.
; Clarkson, Bruno
; Oliveira, Bruno G. de
; Corrêa, Caio C.D.
; Martins, Caleb C.
; Castro-Guedes, Camila F. de
; Souto, Camilla
; Bicho, Carla de L.
; Cunha, Carlo M.
; Barboza, Carlos A. de M.
; Lucena, Carlos A.S. de
; Barreto, Carlos
; Santana, Carlos D.C.M. de
; Agne, Carlos E.Q.
; Mielke, Carlos G.C.
; Caetano, Carlos H.S.
; Flechtmann, Carlos H.W.
; Lamas, Carlos J.E.
; Rocha, Carlos
; Mascarenhas, Carolina S.
; Margaría, Cecilia B.
; Waichert, Cecilia
; Digiani, Celina
; Haddad, Célio F.B.
; Azevedo, Celso O.
; Benetti, Cesar J.
; Santos, Charles M.D. dos
; Bartlett, Charles R.
; Bonvicino, Cibele
; Ribeiro-Costa, Cibele S.
; Santos, Cinthya S.G.
; Justino, Cíntia E.L.
; Canedo, Clarissa
; Bonecker, Claudia C.
; Santos, Cláudia P.
; Carvalho, Claudio J.B. de
; Gonçalves, Clayton C.
; Galvão, Cleber
; Costa, Cleide
; Oliveira, Cléo D.C. de
; Schwertner, Cristiano F.
; Andrade, Cristiano L.
; Pereira, Cristiano M.
; Sampaio, Cristiano
; Dias, Cristina de O.
; Lucena, Daercio A. de A.
; Manfio, Daiara
; Amorim, Dalton de S.
; Queiroz, Dalva L. de
; Queiroz, Dalva L. de
; Colpani, Daniara
; Abbate, Daniel
; Aquino, Daniel A.
; Burckhardt, Daniel
; Cavallari, Daniel C.
; Prado, Daniel de C. Schelesky
; Praciano, Daniel L.
; Basílio, Daniel S.
; Bená, Daniela de C.
; Toledo, Daniela G.P. de
; Takiya, Daniela M.
; Fernandes, Daniell R.R.
; Ament, Danilo C.
; Cordeiro, Danilo P.
; Silva, Darliane E.
; Pollock, Darren A.
; Muniz, David B.
; Gibson, David I.
; Nogueira, David S.
; Marques, Dayse W.A.
; Lucatelli, Débora
; Garcia, Deivys M.A.
; Baêta, Délio
; Ferreira, Denise N.M.
; Rueda-Ramírez, Diana
; Fachin, Diego A.
; Souza, Diego de S.
; Rodrigues, Diego F.
; Pádua, Diego G. de
; Barbosa, Diego N.
; Dolibaina, Diego R.
; Amaral, Diogo C.
; Chandler, Donald S.
; Maccagnan, Douglas H.B.
; Caron, Edilson
; Carvalho, Edrielly
; Adriano, Edson A.
; Abreu Júnior, Edson F. de
; Pereira, Edson H.L.
; Viegas, Eduarda F.G.
; Carneiro, Eduardo
; Colley, Eduardo
; Eizirik, Eduardo
; Santos, Eduardo F. dos
; Shimbori, Eduardo M.
; Suárez-Morales, Eduardo
; Arruda, Eliane P. de
; Chiquito, Elisandra A.
; Lima, Élison F.B.
; Castro, Elizeu B. de
; Orlandin, Elton
; Nascimento, Elynton A. do
; Razzolini, Emanuel
; Gama, Emanuel R.R.
; Araujo, Enilma M. de
; Nishiyama, Eric Y.
; Spiessberger, Erich L.
; Santos, Érika C.L. dos
; Contreras, Eugenia F.
; Galati, Eunice A.B.
; Oliveira Junior, Evaldo C. de
; Gallardo, Fabiana
; Hernandes, Fabio A.
; Lansac-Tôha, Fábio A.
; Pitombo, Fabio B.
; Dario, Fabio Di
; Santos, Fábio L. dos
; Mauro, Fabio
; Nascimento, Fabio O. do
; Olmos, Fabio
; Amaral, Fabio R.
; Schunck, Fabio
; Godoi, Fábio S. P. de
; Machado, Fabrizio M.
; Barbo, Fausto E.
; Agrain, Federico A.
; Ribeiro, Felipe B.
; Moreira, Felipe F.F.
; Barbosa, Felipe F.
; Silva, Fenanda S.
; Cavalcanti, Fernanda F.
; Straube, Fernando C.
; Carbayo, Fernando
; Carvalho Filho, Fernando
; Zanella, Fernando C.V.
; Jacinavicius, Fernando de C.
; Farache, Fernando H.A.
; Leivas, Fernando
; Dias, Fernando M.S.
; Mantellato, Fernando
; Vaz-de-Mello, Fernando Z.
; Gudin, Filipe M.
; Albuquerque, Flávio
; Molina, Flavio B.
; Passos, Flávio D.
; Shockley, Floyd W.
; Pinheiro, Francielly F.
; Mello, Francisco de A.G. de
; Nascimento, Francisco E. de L.
; Franco, Francisco L.
; Oliveira, Francisco L. de
; Melo, Francisco T. de V.
; Quijano, Freddy R.B.
; Salles, Frederico F.
; Biffi, Gabriel
; Queiroz, Gabriel C.
; Bizarro, Gabriel L.
; Hrycyna, Gabriela
; Leviski, Gabriela
; Powell, Gareth S.
; Santos, Geane B. dos
; Morse, Geoffrey E.
; Brown, George
; Mattox, George M.T.
; Zimbrão, Geraldo
; Carvalho, Gervásio S.
; Miranda, Gil F.G.
; Moraes, Gilberto J. de
; Lourido, Gilcélia M.
; Neves, Gilmar P.
; Moreira, Gilson R.P.
; Montingelli, Giovanna G.
; Maurício, Giovanni N.
; Marconato, Gláucia
; Lopez, Guilherme E.L.
; Silva, Guilherme L. da
; Muricy, Guilherme
; Brito, Guilherme R.R.
; Garbino, Guilherme S.T.
; Flores, Gustavo E.
; Graciolli, Gustavo
; Libardi, Gustavo S.
; Proctor, Heather C.
; Gil-Santana, Helcio R.
; Varella, Henrique R.
; Escalona, Hermes E.
; Schmitz, Hermes J.
; Rodrigues, Higor D.D.
; Galvão Filho, Hilton de C.
; Quintino, Hingrid Y.S.
; Pinto, Hudson A.
; Rainho, Hugo L.
; Miyahira, Igor C.
; Gonçalves, Igor de S.
; Martins, Inês X.
; Cardoso, Irene A.
; Oliveira, Ismael B. de
; Franz, Ismael
; Fernandes, Itanna O.
; Golfetti, Ivan F.
; S. Campos-Filho, Ivanklin
; Oliveira, Ivo de S.
; Delabie, Jacques H.C.
; Oliveira, Jader de
; Prando, Jadila S.
; Patton, James L.
; Bitencourt, Jamille de A.
; Silva, Janaina M.
; Santos, Jandir C.
; Arruda, Janine O.
; Valderrama, Jefferson S.
; Dalapicolla, Jeronymo
; Oliveira, Jéssica P.
; Hájek, Jiri
; Morselli, João P.
; Narita, João P.
; Martin, João P.I.
; Grazia, Jocélia
; McHugh, Joe
; Cherem, Jorge J.
; Farias Júnior, José A.S.
; Fernandes, Jose A.M.
; Pacheco, José F.
; Birindelli, José L.O.
; Rezende, José M.
; Avendaño, Jose M.
; Duarte, José M. Barbanti
; Ribeiro, José R. Inácio
; Mermudes, José R.M.
; Pujol-Luz, José R.
; Santos, Josenilson R. dos
; Câmara, Josenir T.
; Teixeira, Joyce A.
; Prado, Joyce R. do
; Botero, Juan P.
; Almeida, Julia C.
; Kohler, Julia
; Gonçalves, Julia P.
; Beneti, Julia S.
; Donahue, Julian P.
; Alvim, Juliana
; Almeida, Juliana C.
; Segadilha, Juliana L.
; Wingert, Juliana M.
; Barbosa, Julianna F.
; Ferrer, Juliano
; Santos, Juliano F. dos
; Kuabara, Kamila M.D.
; Nascimento, Karine B.
; Schoeninger, Karine
; Campião, Karla M.
; Soares, Karla
; Zilch, Kássia
; Barão, Kim R.
; Teixeira, Larissa
; Sousa, Laura D. do N.M. de
; Dumas, Leandro L.
; Vieira, Leandro M.
; Azevedo, Leonardo H.G.
; Carvalho, Leonardo S.
; Souza, Leonardo S. de
; Rocha, Leonardo S.G.
; Bernardi, Leopoldo F.O.
; Vieira, Letícia M.
; Johann, Liana
; Salvatierra, Lidianne
; Oliveira, Livia de M.
; Loureiro, Lourdes M.A. El-moor
; Barreto, Luana B.
; Barros, Luana M.
; Lecci, Lucas
; Camargos, Lucas M. de
; Lima, Lucas R.C.
; Almeida, Lucia M.
; Martins, Luciana R.
; Marinoni, Luciane
; Moura, Luciano de A.
; Lima, Luciano
; Naka, Luciano N.
; Miranda, Lucília S.
; Salik, Lucy M.
; Bezerra, Luis E.A.
; Silveira, Luis F.
; Campos, Luiz A.
; Castro, Luiz A.S. de
; Pinho, Luiz C.
; Silveira, Luiz F.L.
; Iniesta, Luiz F.M.
; Tencatt, Luiz F.C.
; Simone, Luiz R.L.
; Malabarba, Luiz R.
; Cruz, Luiza S. da
; Sekerka, Lukas
; Barros, Lurdiana D.
; Santos, Luziany Q.
; Skoracki, Maciej
; Correia, Maira A.
; Uchoa, Manoel A.
; Andrade, Manuella F.G.
; Hermes, Marcel G.
; Miranda, Marcel S.
; Araújo, Marcel S. de
; Monné, Marcela L.
; Labruna, Marcelo B.
; Santis, Marcelo D. de
; Duarte, Marcelo
; Knoff, Marcelo
; Nogueira, Marcelo
; Britto, Marcelo R. de
; Melo, Marcelo R.S. de
; Carvalho, Marcelo R. de
; Tavares, Marcelo T.
; Kitahara, Marcelo V.
; Justo, Marcia C.N.
; Botelho, Marcia J.C.
; Couri, Márcia S.
; Borges-Martins, Márcio
; Felix, Márcio
; Oliveira, Marcio L. de
; Bologna, Marco A.
; Gottschalk, Marco S.
; Tavares, Marcos D.S.
; Lhano, Marcos G.
; Bevilaqua, Marcus
; Santos, Marcus T.T.
; Domingues, Marcus V.
; Sallum, Maria A.M.
; Digiani, María C.
; Santarém, Maria C.A.
; Nascimento, Maria C. do
; Becerril, María de los A.M.
; Santos, Maria E.A. dos
; Passos, Maria I. da S. dos
; Felippe-Bauer, Maria L.
; Cherman, Mariana A.
; Terossi, Mariana
; Bartz, Marie L.C.
; Barbosa, Marina F. de C.
; Loeb, Marina V.
; Cohn-Haft, Mario
; Cupello, Mario
; Martins, Marlúcia B.
; Christofersen, Martin L.
; Bento, Matheus
; Rocha, Matheus dos S.
; Martins, Maurício L.
; Segura, Melissa O.
; Cardenas, Melissa Q.
; Duarte, Mércia E.
; Ivie, Michael A.
; Mincarone, Michael M.
; Borges, Michela
; Monné, Miguel A.
; Casagrande, Mirna M.
; Fernandez, Monica A.
; Piovesan, Mônica
; Menezes, Naércio A.
; Benaim, Natalia P.
; Reategui, Natália S.
; Pedro, Natan C.
; Pecly, Nathalia H.
; Ferreira Júnior, Nelson
; Silva Júnior, Nelson J. da
; Perioto, Nelson W.
; Hamada, Neusa
; Degallier, Nicolas
; Chao, Ning L.
; Ferla, Noeli J.
; Mielke, Olaf H.H.
; Evangelista, Olivia
; Shibatta, Oscar A.
; Oliveira, Otto M.P.
; Albornoz, Pablo C.L.
; Dellapé, Pablo M.
; Gonçalves, Pablo R.
; Shimabukuro, Paloma H.F.
; Grossi, Paschoal
; Rodrigues, Patrícia E. da S.
; Lima, Patricia O.V.
; Velazco, Paul
; Santos, Paula B. dos
; Araújo, Paula B.
; Silva, Paula K.R.
; Riccardi, Paula R.
; Garcia, Paulo C. de A.
; Passos, Paulo G.H.
; Corgosinho, Paulo H.C.
; Lucinda, Paulo
; Costa, Paulo M.S.
; Alves, Paulo P.
; Roth, Paulo R. de O.
; Coelho, Paulo R.S.
; Duarte, Paulo R.M.
; Carvalho, Pedro F. de
; Gnaspini, Pedro
; Souza-Dias, Pedro G.B.
; Linardi, Pedro M.
; Bartholomay, Pedro R.
; Demite, Peterson R.
; Bulirsch, Petr
; Boll, Piter K.
; Pereira, Rachel M.M.
; Silva, Rafael A.P.F.
; Moura, Rafael B. de
; Boldrini, Rafael
; Silva, Rafaela A. da
; Falaschi, Rafaela L.
; Cordeiro, Ralf T.S.
; Mello, Ramon J.C.L.
; Singer, Randal A.
; Querino, Ranyse B.
; Heleodoro, Raphael A.
; Castilho, Raphael de C.
; Constantino, Reginaldo
; Guedes, Reinaldo C.
; Carrenho, Renan
; Gomes, Renata S.
; Gregorin, Renato
; Machado, Renato J.P.
; Bérnils, Renato S.
; Capellari, Renato S.
; Silva, Ricardo B.
; Kawada, Ricardo
; Dias, Ricardo M.
; Siewert, Ricardo
; Brugnera, Ricaro
; Leschen, Richard A.B.
; Constantin, Robert
; Robbins, Robert
; Pinto, Roberta R.
; Reis, Roberto E. dos
; Ramos, Robson T. da C.
; Cavichioli, Rodney R.
; Barros, Rodolfo C. de
; Caires, Rodrigo A.
; Salvador, Rodrigo B.
; Marques, Rodrigo C.
; Araújo, Rodrigo C.
; Araujo, Rodrigo de O.
; Dios, Rodrigo de V.P.
; Johnsson, Rodrigo
; Feitosa, Rodrigo M.
; Hutchings, Roger W.
; Lara, Rogéria I.R.
; Rossi, Rogério V.
; Gerstmeier, Roland
; Ochoa, Ronald
; Hutchings, Rosa S.G.
; Ale-Rocha, Rosaly
; Rocha, Rosana M. da
; Tidon, Rosana
; Brito, Rosangela
; Pellens, Roseli
; Santos, Sabrina R. dos
; Santos, Sandra D. dos
; Paiva, Sandra V.
; Santos, Sandro
; Oliveira, Sarah S. de
; Costa, Sávio C.
; Gardner, Scott L.
; Leal, Sebastián A. Muñoz
; Aloquio, Sergio
; Bonecker, Sergio L.C.
; Bueno, Sergio L. de S.
; Almeida, Sérgio M. de
; Stampar, Sérgio N.
; Andena, Sérgio R.
; Posso, Sergio R.
; Lima, Sheila P.
; Gadelha, Sian de S.
; Thiengo, Silvana C.
; Cohen, Simone C.
; Brandão, Simone N.
; Rosa, Simone P.
; Ribeiro, Síria L.B.
; Letana, Sócrates D.
; Santos, Sonia B. dos
; Andrade, Sonia C.S.
; Dávila, Stephane
; Vaz, Stéphanie
; Peck, Stewart B.
; Christo, Susete W.
; Cunha, Suzan B.Z.
; Gomes, Suzete R.
; Duarte, Tácio
; Madeira-Ott, Taís
; Marques, Taísa
; Roell, Talita
; Lima, Tarcilla C. de
; Sepulveda, Tatiana A.
; Maria, Tatiana F.
; Ruschel, Tatiana P.
; Rodrigues, Thaiana
; Marinho, Thais A.
; Almeida, Thaís M. de
; Miranda, Thaís P.
; Freitas, Thales R.O.
; Pereira, Thalles P.L.
; Zacca, Thamara
; Pacheco, Thaynara L.
; Martins, Thiago F.
; Alvarenga, Thiago M.
; Carvalho, Thiago R. de
; Polizei, Thiago T.S.
; McElrath, Thomas C.
; Henry, Thomas
; Pikart, Tiago G.
; Porto, Tiago J.
; Krolow, Tiago K.
; Carvalho, Tiago P.
; Lotufo, Tito M. da C.
; Caramaschi, Ulisses
; Pinheiro, Ulisses dos S.
; Pardiñas, Ulyses F.J.
; Maia, Valéria C.
; Tavares, Valeria
; Costa, Valmir A.
; Amaral, Vanessa S. do
; Silva, Vera C.
; Wolff, Vera R. dos S.
; Slobodian, Verônica
; Silva, Vinícius B. da
; Espíndola, Vinicius C.
; Costa-Silva, Vinicius da
; Bertaco, Vinicius de A.
; Padula, Vinícius
; Ferreira, Vinicius S.
; Silva, Vitor C.P. da
; Piacentini, Vítor de Q.
; Sandoval-Gómez, Vivian E.
; Trevine, Vivian
; Sousa, Viviane R.
; Sant’Anna, Vivianne B. de
; Mathis, Wayne N.
; Souza, Wesley de O.
; Colombo, Wesley D.
; Tomaszewska, Wioletta
; Wosiacki, Wolmar B.
; Ovando, Ximena M.C.
; Leite, Yuri L.R.
.
ABSTRACT The limited temporal completeness and taxonomic accuracy of species lists, made available in a traditional manner in scientific publications, has always represented a problem. These lists are invariably limited to a few taxonomic groups and do not represent up-to-date knowledge of all species and classifications. In this context, the Brazilian megadiverse fauna is no exception, and the Catálogo Taxonômico da Fauna do Brasil (CTFB) (http://fauna.jbrj.gov.br/), made public in 2015, represents a database on biodiversity anchored on a list of valid and expertly recognized scientific names of animals in Brazil. The CTFB is updated in near real time by a team of more than 800 specialists. By January 1, 2024, the CTFB compiled 133,691 nominal species, with 125,138 that were considered valid. Most of the valid species were arthropods (82.3%, with more than 102,000 species) and chordates (7.69%, with over 11,000 species). These taxa were followed by a cluster composed of Mollusca (3,567 species), Platyhelminthes (2,292 species), Annelida (1,833 species), and Nematoda (1,447 species). All remaining groups had less than 1,000 species reported in Brazil, with Cnidaria (831 species), Porifera (628 species), Rotifera (606 species), and Bryozoa (520 species) representing those with more than 500 species. Analysis of the CTFB database can facilitate and direct efforts towards the discovery of new species in Brazil, but it is also fundamental in providing the best available list of valid nominal species to users, including those in science, health, conservation efforts, and any initiative involving animals. The importance of the CTFB is evidenced by the elevated number of citations in the scientific literature in diverse areas of biology, law, anthropology, education, forensic science, and veterinary science, among others. publications problem uptodate up date classifications context exception (CTFB http//fauna.jbrj.gov.br/, httpfaunajbrjgovbr http //fauna.jbrj.gov.br/ , jbrj gov br (http://fauna.jbrj.gov.br/) 2015 Brazil 80 specialists 1 2024 133691 133 691 133,69 125138 125 138 125,13 82.3%, 823 82 3 (82.3% 102000 102 000 102,00 7.69%, 769 7 69 (7.69% 11000 11 11,00 . 3,567 3567 567 (3,56 2,292 2292 2 292 (2,29 1,833 1833 833 (1,83 1,447 1447 447 (1,44 1000 1,00 831 (83 628 (62 606 (60 520 (52 50 users science health biology law anthropology education others http//fauna.jbrj.gov.br/ faunajbrjgovbr //fauna.jbrj.gov.br (http://fauna.jbrj.gov.br/ 201 8 202 13369 13 133,6 12513 12 125,1 82.3% (82.3 10200 10 00 102,0 7.69% 76 6 (7.69 1100 11,0 3,56 356 56 (3,5 2,29 229 29 (2,2 1,83 183 83 (1,8 1,44 144 44 (1,4 100 1,0 (8 62 (6 60 52 (5 5 http//fauna.jbrj.gov.br (http://fauna.jbrj.gov.br 20 1336 133, 1251 125, 82.3 (82. 1020 0 102, 7.69 (7.6 110 11, 3,5 35 (3, 2,2 22 (2, 1,8 18 (1, 1,4 14 4 ( 82. (82 7.6 (7. 3, (3 2, (2 (1 7. (7
4.
Biostimulants in initial Growth of DiscoveryTM Bermudagrass
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Santos, Patrick Luan Ferreira dos
; Zabotto, Alessandro Reinaldo
; Silva, Philippe Solano Toledo da
; Nascimento, Matheus Vinícios Leal do
; Godoy, Leandro José Grava de
; Tavares, Armando Reis
; Bôas, Roberto Lyra Villas
.
Abstract The use of bacteria and seaweed extracts as biostimulants to enhance plant growth holds promise for sustainable turfgrass management. This study aimed to investigate the effects of soil application of Azospirillum brasilense (bacterium) and Ascophyllum nodosum (seaweed) extract on the initial growth of DiscoveryTM bermudagrass. The study was conducted using a completely randomized design with plots measuring 0.25 m², each with a 0.5 m border. Two separate experiments were conducted, each involving four doses of biostimulants and five repetitions. The biostimulant treatments consisted of 0, 2, 4, and 6 mL L¹ A. brasilense inoculant and 0, 5, 10, and 15 mL L¹ A. nodosum seaweed extract. These treatments were uniformly applied to the soil at a rate of 100 mL m², with applications at 0, 30, and 60 days after the start of the experiment. After 90 days, the parameters green color index, green cover rate, turfgrass height, and vegetation index (normalized difference), were evaluated. The results indicated that both biostimulants significantly promoted the initial growth of DiscoveryTM bermudagrass. As the doses of the biostimulants increased, there was a corresponding increase in biomass and improved development of the turfgrass. The most pronounced responses were observed with a dose of 6 mL L¹ of the bacteria inoculant and 15 mL L¹ of the seaweed extract. These biostimulants fostered better turf coverage, making it challenging for weeds to establish, and potentially accelerating the production of sod grass. management bacterium (bacterium (seaweed bermudagrass 025 0 25 0.2 m² 05 5 0. border repetitions 2 4 L A 10 1 30 experiment 9 height normalized difference, difference , difference) evaluated increased coverage establish grass 02 3
Resumo O uso de extratos de bactérias e algas marinhas como bioestimulantes para promover o crescimento das plantas apresenta potencial para o manejo sustentável em áreas de produção de grama. Este estudo teve como objetivo investigar os efeitos da aplicação no solo do Azospirillum brasilense (bactéria) e do extrato de Ascophyllum nodosum (alga marinha) no crescimento inicial do capim bermuda DiscoveryTM. O estudo foi conduzido usando um desenho completamente aleatório com parcelas de 0,25 m², com bordas de 0,5 m. Foram realizados dois experimentos separados, cada um envolvendo quatro doses de bioestimulantes e cinco repetições. Os tratamentos com bioestimulantes consistiram em 0, 2, 4 e 6 mL L¹ de inoculante de A. brasilense e 0, 5, 10 e 15 mL L¹ de extrato de alga marinha A. nodosum. Os tratamentos foram aplicados uniformemente no solo (100 mL m²), com aplicações feitas 0, 30 e 60 dias após o início do experimento. Após 90 dias, foram avaliados os parâmetros índice de cor verde, taxa de cobertura verde, altura do gramado e índice de vegetação (diferença normalizada). Os resultados mostraram que os bioestimulantes promoveram o crescimento inicial da grama DiscoveryTM. Houve aumento da biomassa e melhor desenvolvimento do gramado, à medida que aumentavam as doses dos bioestimulantes. As respostas mais significativas foram observadas com a dose de 6 mL L-1 do inoculante bacteriano e 15 mL L-1 do extrato de algas marinhas. Os bioestimulantes promoveram melhor fechamento do gramado, dificultando o aparecimento de ervas daninhas e possivelmente acelerando a produção de grama. bactéria (bactéria DiscoveryTM 025 0 25 0,2 m² m 05 5 separados repetições 2 L A 1 100 (10 , m²) 3 experimento 9 verde diferença normalizada. normalizada . normalizada) L1 L- 02 (1 (
5.
Long-term oncological and surgical outcomes after Video Endoscopic Inguinal Lymphadenectomy (VEIL) in patients with penile cancer Longterm Long term VEIL (VEIL
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Tobias-Machado, Marcos
; Ornellas, Antonio A.
; Hidaka, Alexandre K.
; Medina, Luis G.
; Mattos, Pablo A. L.
; Besio, Ruben S.
; Abreu, Diego
; Castro, Pedro R.
; Nishimoto, Ricardo H.
; Astigueta, Juan
; Dourado, Aurus
; Machado, Roberto D.
; Magnabosco, Wesley J.
; Corona-Montes, Victor
; Villoldo, Gustavo M.
; Zampolli, Hamilton C.
; Taha, Anis
; Auad, Pericles R.
; Faria, Eliney F.
; Arantes, Paulo B. O.
; Tavares, Alessandro
; Nascimento, Francisco S. M. S.
; Brazão Jr., Eder S.
; Rocha, Maurício M.
; Costa, Walter H.
; Panico, Vinicius
; Reis, Leonardo O.
; Almeida-Carrera, Roberto J.
; Silva, Rafael C.
; Zequi, Stênio C.
; Calixto, José R. R.
; Sotelo, Rene
.
ABSTRACT Objective: To report outcomes from the largest multicenter series of penile cancer patients undergoing video endoscopic inguinal lymphadenectomy (VEIL). Materials and Methods: Retrospective multicenter analysis. Authors of 21 centers from the Penile Cancer Collaborative Coalition-Latin America (PeC-LA) were included. All centers performed the procedure following the same previously described standardized technique. Inclusion criteria included penile cancer patients with no palpable lymph nodes and intermediate/high-risk disease and those with non-fixed palpable lymph nodes less than 4 cm in diameter. Categorical variables are shown as percentages and frequencies whereas continuous variables as mean and range. Results: From 2006 to 2020, 210 VEIL procedures were performed in 105 patients. Mean age was 58 (45-68) years old. Mean operative time was 90 minutes (60-120). Mean lymph node yield was 10 nodes (6-16). Complication rate was 15.7%, including severe complications in 1.9% of procedures. Lymphatic and skin complications were noted in 8.6 and 4.8% of patients, respectively. Histopathological analysis revealed lymph node involvement in 26.7% of patients with non-palpable nodes. Inguinal recurrence was observed in 2.8% of patients. 10y- overall survival was 74.2% and 10-y cancer specific survival was 84.8%. CSS for pN0, pN1, pN2 and pN3 were 100%, 82.4%, 72.7% and 9.1%, respectively. Conclusion: VEIL seems to offer appropriate long term oncological control with minimal morbidity. In the absence of non-invasive stratification measures such as dynamic sentinel node biopsy, VEIL emerged as the alternative for the management of non-bulky lymph nodes in penile cancer. Objective VEIL. . (VEIL) Methods 2 CoalitionLatin Coalition Latin PeCLA PeC LA (PeC-LA technique intermediate/highrisk intermediatehighrisk intermediate/high risk intermediate high nonfixed non fixed diameter range Results 200 2020 5 4568 45 68 (45-68 old 9 60120. 60120 60 120 (60-120) 1 616. 616 6 16 (6-16) 157 15 7 15.7% 19 1.9 86 8 8. 48 4.8 respectively 267 26 26.7 nonpalpable 28 2.8 10y y 742 74 74.2 848 84 84.8% pN0 pN pN1 100 100% 824 82 82.4% 727 72 72.7 91 9.1% Conclusion morbidity noninvasive invasive biopsy nonbulky bulky (VEIL highrisk intermediatehigh 20 202 456 (45-6 6012 12 (60-120 61 (6-16 15.7 1. 4. 26. 2. 74. 84.8 82.4 72. 9.1 (45- 601 (60-12 (6-1 15. 84. 82. 9. (45 (60-1 (6- (4 (60- (6 ( (60
6.
Guidelines from the Brazilian society of surgical oncology regarding indications and technical aspects of neck dissection in papillary, follicular, and medullary thyroid cancers papillary follicular
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Farias, Terence
; Kowalski, Luiz Paulo
; Dias, Fernando
; Barreira, Carlos S. Ritta
; Vartanian, José Guilherme
; Tavares, Marcos Roberto
; Vaisman, Fernanda
; Momesso, Denise
; Oliveira, Alexandre Ferreira
; Pinheiro, Rodrigo Nascimento
; Ribeiro, Heber Salvador de Castro
.
ABSTRACT Objective: The purpose of these guidelines is to provide specific recommendations for the surgical treatment of neck metastases in patients with papillary, follicular, and medullary thyroid carcinomas. Materials and methods: Recommendations were developed based on research of scientific articles (preferentially meta-analyses) and guidelines issued by international medical specialty societies. The American College of Physicians’ Guideline Grading System was used to determine the levels of evidence and grades of recommendations. The following questions were answered: A) Is elective neck dissection indicated in the treatment of papillary, follicular, and medullary thyroid carcinoma? B) When should central, lateral, and modified radical neck dissection be performed? C) Could molecular tests guide the extent of the neck dissection? Results/conclusion: Recommendation 1: Elective central neck dissection is not indicated in patients with cN0 well-differentiated thyroid carcinoma or in those with noninvasive T1 and T2 tumors but may be considered in T3-T4 tumors or in the presence of metastases in the lateral neck compartments. Recommendation 2: Elective central neck dissection is recommended in medullary thyroid carcinoma. Recommendation 3: Selective neck dissection of levels II–V should be indicated to treat neck metastases in papillary thyroid cancer, an approach that decreases the risk of recurrence and mortality. Recommendation 4: Compartmental neck dissection is indicated in the treatment of lymph node recurrence after elective or therapeutic neck dissection; “berry node picking” is not recommended. Recommendation 5: There are currently no recommendations regarding the use of molecular tests in guiding the extent of neck dissection in thyroid cancer. Objective follicular carcinomas methods preferentially metaanalyses meta analyses meta-analyses societies Physicians answered A B performed C Results/conclusion Resultsconclusion Results conclusion 1 cN welldifferentiated well differentiated T T3T4 TT T3 T4 T3-T compartments 2 3 IIV II V cancer mortality 4 berry picking 5 T3T
7.
Relationships between follicle and corpus luteum size and vascularization with ovulation, progesterone production, and pregnancy in Nellore beef cattle ovulation production
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Couto, Samuel Rodrigues Bonamichi do
; Guerson, Yuri Barbosa
; Morais, Rita de Cássia Lima
; Grillo, Gustavo Fernandes
; Andrade, João Paulo Nascimento
; Jacob, Julio Cesar Ferraz
; Barbero, Rondineli Pavezzi
; Mello, Marco Roberto Bourg de
.
ABSTRACT The objective of this study was to evaluate the relationships between preovulatory follicle (POF) and corpus luteum (CL) diameters, and POF and CL vascular perfusion with progesterone production, ovulation, and pregnancy in Nellore cows subjected to timed artificial insemination (TAI). Nellore cows (n = 201) were subjected to ovulation synchronization and later to ultrasound evaluation of POF and CL at the time of insemination (D0) and seven days later (D7), respectively. Females were divided into three categories according to the POF diameter assessed at the time of insemination: small (SF), medium (MF), and large (LF) follicles. The LF group had a greater number and intensity of pixels in the POF ultrasound exam compared with the SF group. The CL flow intensity and progesterone concentration were also higher in the LF group. The SF group showed lower flow intensity and lower ovulation rate compared with the others. When non-pregnant females were compared to pregnant ones, no difference was observed in any of the analyzed variables. The results show for the first time in Nellore cattle the relationship between the size of ovarian structures and blood flow (quantity and intensity) as well as the ability of the CL to produce progesterone. The intensity of the POF pixels proved to be relevant, demonstrating correlations with the size and flow of the CL, which were not found when evaluating only the number of pixels, thus revealing the importance of evaluating complementary characteristics of the flow. (POF (CL diameters production TAI. TAI . (TAI) n 201 D0 D (D0 D7, D7 , (D7) respectively SF, (SF) MF, MF (MF) (LF follicles others nonpregnant non ones variables quantity relevant (TAI 20 (D (D7 (SF (MF 2
8.
Diretriz da SBC sobre Diagnóstico e Tratamento de Pacientes com Cardiomiopatia da Doença de Chagas – 2023 202 20 2
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Marin-Neto, José Antonio
; Rassi Jr, Anis
; Oliveira, Gláucia Maria Moraes
; Correia, Luís Claudio Lemos
; Ramos Júnior, Alberto Novaes
; Luquetti, Alejandro Ostermayer
; Hasslocher-Moreno, Alejandro Marcel
; Sousa, Andréa Silvestre de
; Paola, Angelo Amato Vincenzo de
; Sousa, Antônio Carlos Sobral
; Ribeiro, Antonio Luiz Pinho
; Correia Filho, Dalmo
; Souza, Dilma do Socorro Moraes de
; Cunha-Neto, Edecio
; Ramires, Felix Jose Alvarez
; Bacal, Fernando
; Nunes, Maria do Carmo Pereira
; Martinelli Filho, Martino
; Scanavacca, Maurício Ibrahim
; Saraiva, Roberto Magalhães
; Oliveira Júnior, Wilson Alves de
; Lorga-Filho, Adalberto Menezes
; Guimarães, Adriana de Jesus Benevides de Almeida
; Braga, Adriana Lopes Latado
; Oliveira, Adriana Sarmento de
; Sarabanda, Alvaro Valentim Lima
; Pinto, Ana Yecê das Neves
; Carmo, Andre Assis Lopes do
; Schmidt, Andre
; Costa, Andréa Rodrigues da
; Ianni, Barbara Maria
; Markman Filho, Brivaldo
; Rochitte, Carlos Eduardo
; Macêdo, Carolina Thé
; Mady, Charles
; Chevillard, Christophe
; Virgens, Cláudio Marcelo Bittencourt das
; Castro, Cleudson Nery de
; Britto, Constança Felicia De Paoli de Carvalho
; Pisani, Cristiano
; Rassi, Daniela do Carmo
; Sobral Filho, Dário Celestino
; Almeida, Dirceu Rodrigues de
; Bocchi, Edimar Alcides
; Mesquita, Evandro Tinoco
; Mendes, Fernanda de Souza Nogueira Sardinha
; Gondim, Francisca Tatiana Pereira
; Silva, Gilberto Marcelo Sperandio da
; Peixoto, Giselle de Lima
; Lima, Gustavo Glotz de
; Veloso, Henrique Horta
; Moreira, Henrique Turin
; Lopes, Hugo Bellotti
; Pinto, Ibraim Masciarelli Francisco
; Ferreira, João Marcos Bemfica Barbosa
; Nunes, João Paulo Silva
; Barreto-Filho, José Augusto Soares
; Saraiva, José Francisco Kerr
; Lannes-Vieira, Joseli
; Oliveira, Joselina Luzia Menezes
; Armaganijan, Luciana Vidal
; Martins, Luiz Cláudio
; Sangenis, Luiz Henrique Conde
; Barbosa, Marco Paulo Tomaz
; Almeida-Santos, Marcos Antonio
; Simões, Marcos Vinicius
; Yasuda, Maria Aparecida Shikanai
; Moreira, Maria da Consolação Vieira
; Higuchi, Maria de Lourdes
; Monteiro, Maria Rita de Cassia Costa
; Mediano, Mauro Felippe Felix
; Lima, Mayara Maia
; Oliveira, Maykon Tavares de
; Romano, Minna Moreira Dias
; Araujo, Nadjar Nitz Silva Lociks de
; Medeiros, Paulo de Tarso Jorge
; Alves, Renato Vieira
; Teixeira, Ricardo Alkmim
; Pedrosa, Roberto Coury
; Aras Junior, Roque
; Torres, Rosalia Morais
; Povoa, Rui Manoel dos Santos
; Rassi, Sergio Gabriel
; Alves, Silvia Marinho Martins
; Tavares, Suelene Brito do Nascimento
; Palmeira, Swamy Lima
; Silva Júnior, Telêmaco Luiz da
; Rodrigues, Thiago da Rocha
; Madrini Junior, Vagner
; Brant, Veruska Maia da Costa
; Dutra, Walderez Ornelas
; Dias, João Carlos Pinto
.
9.
Lesão Miocárdica e Prognóstico em Pacientes Hospitalizados com COVID-19 no Brasil: Resultados do Registro Nacional de COVID-19 COVID19 COVID 19 COVID-1 Brasil COVID1 1 COVID-
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Barbosa, Hannah Cardoso
; Martins, Maria Auxiliadora Parreiras
; Jesus, Jordana Cristina de
; Meira, Karina Cardoso
; Passaglia, Luiz Guilherme
; Sacioto, Manuela Furtado
; Bezerra, Adriana Falangola Benjamin
; Schwarzbold, Alexandre Vargas
; Maurílio, Amanda de Oliveira
; Farace, Barbara Lopes
; Silva, Carla Thais Cândida Alves da
; Cimini, Christiane Corrêa Rodrigues
; Silveira, Daniel Vitorio
; Carazai, Daniela do Reis
; Ponce, Daniela
; Costa, Emanuel Victor Alves
; Manenti, Euler Roberto Fernandes
; Cenci, Evelin Paola de Almeida
; Bartolazzi, Frederico
; Madeira, Glícia Cristina de Castro
; Nascimento, Guilherme Fagundes
; Velloso, Isabela Vasconcellos Pires
; Batista, Joanna d’Arc Lyra
; Morais, Júlia Drumond Parreiras de
; Carvalho, Juliana da Silva Nogueira
; Ruschel, Karen Brasil
; Martins, Karina Paula Medeiros Prado
; Zandoná, Liege Barella
; Menezes, Luanna Silva Monteiro
; Kopittke, Luciane
; Castro, Luís César de
; Nasi, Luiz Antônio
; Floriani, Maiara Anschau
; Souza, Maíra Dias
; Carneiro, Marcelo
; Bicalho, Maria Aparecida Camargos
; Lima, Maria Clara Pontello Barbosa
; Godoy, Mariana Frizzo de
; Guimarães-Júnior, Milton Henriques
; Mendes, Paulo Mascarenhas
; Delfino-Pereira, Polianna
; Ribeiro, Raquel Jaqueline Eder
; Finger, Renan Goulart
; Menezes, Rochele Mosmann
; Francisco, Saionara Cristina
; Araújo, Silvia Ferreira
; Oliveira, Talita Fischer
; Oliveira, Thainara Conceição de
; Polanczyk, Carisi Anne
; Marcolino, Milena Soriano
.
Abstract Background Cardiovascular complications of COVID-19 are important aspects of the disease’s pathogenesis and prognosis. Evidence on the prognostic role of troponin and myocardial injury in Latin American hospitalized COVID-19 patients is still scarce. Objectives To evaluate myocardial injury as independent predictor of in-hospital mortality and invasive mechanical ventilation support in hospitalized patients, from the Brazilian COVID-19 Registry. Methods This cohort study is a substudy of the Brazilian COVID-19 Registry, conducted in 31 Brazilian hospitals of 17 cities, March-September 2020. Primary outcomes included in-hospital mortality and invasive mechanical ventilation support. Models for the primary outcomes were estimated by Poisson regression with robust variance, with statistical significance of p<0.05. Results Of 2,925 patients (median age of 60 years [48-71], 57.1% men), 27.3% presented myocardial injury. The proportion of patients with comorbidities was higher among patients with cardiac injury (median 2 [1-2] vs. 1 [0-2]). Patients with myocardial injury had higher median levels of brain natriuretic peptide, lactate dehydrogenase, creatine phosphokinase, N-terminal pro-brain natriuretic peptide, and C-reactive protein than patients without myocardial injury. As independent predictors, C-reactive protein and platelet counts were related to the risk of death, and neutrophils and platelet counts were related to the risk of invasive mechanical ventilation support. Patients with high troponin levels presented a higher risk of death (RR 2.03, 95% CI 1.60-2.58) and invasive mechanical ventilation support (RR 1.87, 95% CI 1.57-2.23), when compared to those with normal troponin levels. Conclusion Cardiac injury was an independent predictor of in-hospital mortality and the need for invasive mechanical ventilation support in hospitalized COVID-19 patients. COVID19 COVID 19 COVID-1 diseases disease s prognosis scarce inhospital hospital Registry 3 cities MarchSeptember March September 2020 variance p005 p 0 05 p<0.05 2925 925 2,92 6 4871, 4871 48 71 , [48-71] 571 57 57.1 men, men men) 273 27 27.3 12 [1-2 vs 02. 02 . [0-2]) peptide dehydrogenase phosphokinase Nterminal N terminal probrain pro Creactive C reactive predictors RR 203 03 2.03 95 1.602.58 160258 1.60 2.58 58 1.60-2.58 187 87 1.87 1.572.23, 157223 1.57 2.23 23 1.57-2.23) COVID1 COVID- 202 p00 p<0.0 292 92 2,9 487 4 7 [48-71 5 57. 27. [1- [0-2] 20 2.0 9 602 1.602.5 16025 160 1.6 258 2.5 1.60-2.5 18 8 1.8 572 1.572.23 15722 157 1.5 223 2.2 1.57-2.23 p0 p<0. 29 2, [48-7 [1 [0-2 2. 1.602. 1602 16 1. 25 1.60-2. 1.572.2 1572 15 22 1.57-2.2 p<0 [48- [ [0- 1.602 1.60-2 1.572. 1.57-2. p< [48 [0 1.60- 1.572 1.57-2 [4 1.57-
Resumo Fundamento As complicações cardiovasculares da COVID-19 são aspectos importantes da patogênese e do prognóstico da doença. Evidências do papel prognóstico da troponina e da lesão miocárdica em pacientes hospitalizados com COVID-19 na América Latina são ainda escassos. Objetivos Avaliar a lesão miocárdica como preditor independente de mortalidade hospitalar e suporte ventilatório mecânico em pacientes hospitalizados, do registro brasileiro de COVID-19. Métodos Este estudo coorte é um subestudo do registro brasileiro de COVID-19, conduzido em 31 hospitais brasileiros de 17 cidades, de março a setembro de 2020. Os desfechos primários incluíram mortalidade hospitalar e suporte ventilatório mecânico invasivo. Os modelos para os desfechos primários foram estimados por regressão de Poisson com variância robusta, com significância estatística de p<0,05. Resultados Dos 2925 pacientes [idade mediana de 60 anos (48-71), 57,1%], 27,3% apresentaram lesão miocárdica. A proporção de pacientes com comorbidades foi maior nos pacientes com lesão miocárdica [mediana 2 (1-2) vs. 1 (0-20)]. Os pacientes com lesão miocárdica apresentaram maiores valores medianos de peptídeo natriurético cerebral, lactato desidrogenase, creatina fosfoquinase, N-terminal do pró-peptídeo natriurético tipo B e proteína C reativa em comparação a pacientes sem lesão miocárdica. Como fatores independentes, proteína C reativa e contagem de plaquetas foram relacionados com o risco de morte, e neutrófilos e contagem de plaquetas foram relacionados ao risco de suporte ventilatório mecânico invasivo. Os pacientes com níveis elevados de troponina apresentaram um maior risco de morte (RR 2,03, IC95% 1,60-2,58) e suporte ventilatório mecânico (RR 1,87;IC95% 1,57-2,23), em comparação àqueles com níveis de troponina normais. Conclusão Lesão cardíaca foi um preditor independente de mortalidade hospitalar e necessidade de suporte ventilatório mecânico em pacientes hospitalizados com COVID-19. COVID19 COVID 19 COVID-1 doença escassos COVID19. 19. COVID19, 19, 3 cidades 2020 invasivo robusta p005 p 0 05 p<0,05 292 idade 6 4871, 4871 48 71 , (48-71) 57,1%, 571 57,1% 57 57,1%] 273 27 27,3 12 (1-2 vs 020. 020 20 . (0-20)] cerebral desidrogenase fosfoquinase Nterminal N terminal própeptídeo pró independentes RR 203 03 2,03 IC95 IC 1,602,58 160258 1,60 2,58 58 1,60-2,58 1,87IC95% 187IC95 1,87 87 1,87;IC95 1,572,23, 157223 1,57 2,23 23 1,57-2,23) normais COVID1 COVID- 202 p00 p<0,0 29 487 4 7 (48-71 57,1 5 27, (1- 02 (0-20) 2,0 IC9 602 1,602,5 16025 160 1,6 258 2,5 1,60-2,5 87IC95 1,87IC95 187IC9 187 1,8 8 1,87;IC9 572 1,572,23 15722 157 1,5 223 2,2 1,57-2,23 p0 p<0, (48-7 57, (1 (0-20 2, 1,602, 1602 16 1, 25 1,60-2, 87IC9 1,87IC9 187IC 18 1,87;IC 1,572,2 1572 15 22 1,57-2,2 p<0 (48- ( (0-2 1,602 1,60-2 87IC 1,87IC 1,572, 1,57-2, p< (48 (0- 1,60- 1,572 1,57-2 (4 (0 1,57-
10.
In-hospital severe COVID-19 in a philanthropic tertiary hospital setting: is asthma a concern? A retrospective study
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ABSTRACT BACKGROUND: The frequency of coronavirus disease 2019 (COVID-19) cases among asthmatics has been reported to be reduced. However, the findings regarding the association between asthma and the risk of severe COVID-19 have been divergent. OBJECTIVE: To investigate whether asthma is associated with a reduced risk of development of severe COVID-19. DESIGN AND SETTING: Retrospective analysis on COVID-19 surveillance databases at two tertiary-level hospitals in São Paulo, Brazil. METHODS: The medical records of patients hospitalized due to COVID-19 between March and August 2020 were reviewed in accordance with the clinical, laboratorial, radiological and epidemiological criteria for COVID-19, and for comorbidities. RESULTS: Among the adult patients included (> 18 years of age) there were 52 asthmatics and 1,318 non-asthmatics. Their median ages and interquartile ranges (IQR) were, respectively, 54 (41-69) and 60 (44-72) years. At least one comorbidity was seen in 73% of asthmatics and 56% of the non-asthmatics. Among the asthmatics, most presented mild asthma (92%) and the prevalence of chronic obstructive pulmonary disease (COPD) was high (27%). The asthmatics presented an unadjusted odds ratio (OR) for severe COVID-19 of 0.89 (95% confidence interval, CI 0.5-1.56); and OR 0.88 (95% CI 0.5 -1.68) after multivariable adjustment. Age > 60 years, male sex, hypertension, diabetes, cancer and homelessness were covariates associated with increased odds for severe COVID-19. Kaplan-Meier estimated survival over hospitalization of up to 30 days did not differ between the groups (log-rank P = 0.09). CONCLUSIONS: The association between asthma and decreased risk of severe COVID-19 or increased survival was statistically non-significant.
11.
Encarceramento em massa e racismo: a realidade no sistema prisional sergipano
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Santos, Paulo Roberto Felix dos
; Santos, Laryssa Gabriella Gonçalves dos
; Santos, Fabiane Ferreira Nascimento
; Menezes, Maria Tailaine dos Santos
.
Resumo: O objetivo deste artigo é apresentar dados sobre a dinâmica contemporânea da política de encarceramento na realidade sergipana, com ênfase na racialização que tem incidido, majoritariamente, sobre a população negra. Fundamentada no materialismo histórico-dialético, articula dados de natureza bibliográfica e documental, utilizando as informações disponíveis no Levantamento Nacional de Informações Penitenciárias (INFOPEN), bem como contribuições da teoria social marxista e da criminologia crítica. Com os resultados, expõe-se parte do perfil da população prisional no estado nos anos de 2018 e 2019. Constatou-se que existe um perfil racializado da população carcerária com predominância de homens negros, além da tendência de aumento da população carcerária feminina, com índices acima da média nacional, bem como das condições de desumanização e de violação de direitos, a que estes sujeitos estão submetidos, reafirmando uma articulação estrutural entre capitalismo, racismo e sexismo, a partir da ampliação das estratégias de criminalização desses segmentos por meio do cárcere.
Abstract: The aim of the text is to present data on the contemporary dynamics of incarceration policy in Sergipe reality, with an emphasis on the racialization that has mostly focused on the black population. Based on historical-dialectical materialism, it articulates bibliographic and documentary data, using data available from the National Survey of Penitentiary Information (INFOPEN), as well as contributions from Marxist social theory and critical criminology. With the results, part of the profile of the prison population in the state in the years 2018 and 2019 is exposed. It was found that there is a racialized profile of the prison population with a predominance of black men, in addition to the tendency of the prison population to increase female, with rates above the national average, as well as the conditions of dehumanization and violation of rights, to which these subjects are subjected, reaffirming a structural articulation between capitalism, racism and sexism, from the expansion of criminalization strategies of these segments by middle of prison.
12.
How can nutritional additives modify ruminant nutrition?
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Silveira Pimentel, Paulo Roberto
; dos Santos Brant, Lara Maria
; Vasconcelos de Oliveira Lima, Anny Graycy
; Cotrim, Daniela Costa
; Costa Nascimento, Thiago Vinicius
; Lopes Oliveira, Ronaldo
.
Revista de la Facultad de Ciencias Agrarias. Universidad Nacional de Cuyo
- Journal Metrics
Resumen Esta revisión tuvo como objetivo exponer las relaciones entre los aditivos en la dieta de los rumiantes y las consecuencias causadas en su nutrición. Los aditivos alimentarios se utilizan en la nutrición de los rumiantes para mejorar las características productivas y/o la calidad de los productos. Hay diversas categorías de aditivos disponibles para la nutrición de rumiantes, con énfasis en antibióticos, prebióticos, probióticos, extractos de plantas y enzimas exógenas. Los antibióticos, los aceites esenciales y el quitosano actúan seleccionando bacterias sensibles y consecuentemente modulan el patrón de fermentación ruminal. Los prebióticos favorecen la microbiota, proporcionando una mayor digestión y producción de ácidos grasos volátiles. Los probióticos son microorganismos que mejoran el ambiente ruminal, lo que resulta en una mayor digestión y producción de ácidos grasos volátiles. Las enzimas exógenas actúan sinérgicamente con las enzimas secretadas por los microorganismos ruminales, además de favorecer la adhesión microbiana y colonización de las partículas, ayudan en la degradación del alimento. Los taninos, ya sea alterando el estándar de fermentación y/o modificando la microbiota ruminal, todos los aditivos son efectivos para mejorar el rendimiento animal. Sin embargo, los efectos de los aditivos sobre los productos están relacionados con la calidad de la dieta.
Abstract This review illustrates the relationships between additives in the diets of ruminants and the consequence for ruminant nutrition. Feed additives are used to improve animal perfor mance and/or the quality of the products. There are several categories of additives available for ruminant nutrition, with emphasis on antibiotics, prebiotics, probiotics, plant extracts, and exogenous enzymes. Antibiotics, essential oils, and chitosan act by selecting sensitive bacteria, consequently modulating the ruminal fermentation pattern. Prebiotics favor microbial growth, providing greater digestion and the production of volatile fatty acids. Probiotics are living microorganisms that improve the ruminal environment, promoting microbial growth and resulting in increased digestion and the production of volatile fatty acids. Exogenous enzymes act synergistically with the enzymes secreted by the ruminal microorganisms, besides favoring microbial adhesion and colonization and facilitating feed degradation. Tannins, whether altering the fermentation standard and/or modifying the ruminal microbiota population, are effective in improving animal performance. However, the effects of additives on the quality of the products are linked to diet quality.
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13.
Justificativa e limitações da SpO2/FiO2 como possível substituta da PaO2/FiO2 em diferentes cenários pré-clínicos e clínicos
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Carvalho, Eduardo Butturini de
; Leite, Thiago Ravache Sobreira
; Sacramento, Raquel Ferreira de Magalhães
; Nascimento, Paulo Roberto Loureiro do
; Samary, Cynthia dos Santos
; Rocco, Patrícia Rieken Macedo
; Silva, Pedro Leme
.
RESUMO Embora a PaO2/FiO2 derivada da gasometria arterial continue sendo o padrão-ouro do diagnóstico de insuficiência respiratória aguda, a SpO2/FiO2 tem sido investigada como potencial substituta. Esta revisão narrativa apresenta o estado da literatura pré-clínica e clínica sobre a SpO2/FiO2 como possível substituta da PaO2/FiO2 e para uso como marcador diagnóstico e prognóstico; ainda, é fornecida uma visão geral da oximetria de pulso e suas limitações, além da avaliação da utilidade da SpO2/ FiO2 como substituta da PaO2/FiO2 em pacientes com COVID-19. Ao todo, foram encontrados 49 estudos comparando SpO2/FiO2 e PaO2/ FiO2 com base em uma estratégia de pesquisa mínima. A maioria dos estudos foi realizada em recémnascidos, alguns foram realizados em adultos com síndrome do desconforto respiratório agudo, e outros foram realizados em outros cenários clínicos (incluindo poucos em pacientes com COVID-19). Há certa evidência de que os critérios de SpO2/FiO2 podem substituir a PaO2/FiO2 em diferentes cenários clínicos. Isso é reforçado pelo fato de que devem ser evitados procedimentos invasivos desnecessários em pacientes com insuficiência respiratória aguda. É inegável que os oxímetros de pulso estão cada vez mais difundidos e podem proporcionar um monitoramento sem custos. Portanto, substituir a PaO2/FiO2 pela SpO2/FiO2 pode permitir que instalações com recursos limitados diagnostiquem a insuficiência respiratória aguda de maneira objetiva.
ABSTRACT Although the PaO 2/FiO 2 derived from arterial blood gas analysis remains the gold standard for the diagnosis of acute respiratory failure, the SpO2/FiO2 has been investigated as a potential substitute. The current narrative review presents the state of the preclinical and clinical literature on the SpO2/FiO2 as a possible substitute for PaO2/FiO2 and for use as a diagnostic and prognostic marker; provides an overview of pulse oximetry and its limitations, and assesses the utility of SpO2/ FiO2 as a surrogate for PaO2/FiO2 in COVID-19 patients. Overall, 49 studies comparing SpO2/FiO2 and PaO2/FiO2 were found according to a minimal search strategy. Most were conducted on neonates, some were conducted on adults with acute respiratory distress syndrome, and a few were conducted in other clinical scenarios (including a very few on COVID-19 patients). There is some evidence that the SpO2/ FiO2 criteria can be a surrogate for PaO2/FiO2 in different clinical scenarios. This is reinforced by the fact that unnecessary invasive procedures should be avoided in patients with acute respiratory failure. It is undeniable that pulse oximeters are becoming increasingly widespread and can provide costless monitoring. Hence, replacing PaO2/FiO2 with SpO2/FiO2may allow resourcelimited facilities to objectively diagnose acute respiratory failure.
14.
Comparison of hematological parameters between single and twin pregnancies in Dorper ewes during gestation, lambing, and postpartum
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Santarosa, Bianca Paola
; Dantas, Gabriela Nascimento
; Ferreira, Danilo Otávio Laurenti
; Hooper, Henrique Barbosa
; Porto, Ana Carolina Rusca Correa
; Garcia, Silvia Maria França Carvalho
; Surian, Soraya Regina Sacco
; Pieruzzi, Paula Adriane Piccolo
; Silva, Andreza Amaral da
; Gonçalves, Roberto Calderon
.
RESUMO: O sistema hematopoiético sofre mudanças durante a gestação para atender o desenvolvimento fetal e as necessidades maternas. Este estudo comparou os parâmetros hematológicos entre ovelhas com gestação simples e gemelar durante a prenhez, parto e pós-parto. O estudo foi realizado em 60 ovelhas Dorper prenhes, saudáveis, divididas em dois grupos experimentais: Grupo 1 (G1) com gestação simples (n = 30); e Grupo 2 (G2) com gestação gemelar (n = 30). Amostras de sangue foram colhidos de todas as ovelhas em diferentes momentos: imediatamente antes da inseminação artificial em tempo fixo (IA); nos dias 30, 90, 120, 130 e 140 de gestação; imediatamente após o parto; e às 24h e 48h pós-parto. A análise estatística comparou os dois grupos nos diferentes momentos (P < 0,05). Anemia leve, normocítica e hipocrômica foi detectada desde a IA e ao longo da gestação, nas ovelhas de ambos os grupos, mas não houve relevância clínica. Na fase periparto (do 140º dia de gestação às 48h pós-parto), as ovelhas com gestação gemelar (G2) mostraram valores do eritrograma e proporção neutrófilos: linfócitos mais elevados do que as ovelhas com gestação simples (G1). Isso indicou maior adaptação hematopoiética da ovelha para o desenvolvimento de dois fetos. Com exceção do número de eosinófilos, todos os parâmetros do leucograma foram influenciados pela gestação de forma semelhante em ambos os grupos, e foi caracterizada principalmente por leucocitose com neutrofilia no periparto devido ao alto nível de cortisol endógeno no parto. Assim, os achados mostraram que a gestação foi um evento fisiológico estressante que aumentou a contagem de leucócitos com leve alteração no eritrograma de ovelhas Dorper.
ABSTRACT: The hematopoietic system changes during the pregnancy to carry fetal development and maternal needs. This study compared the hematological parameters between ewes with single and twin pregnancies during gestation, delivery, and postpartum. The experiment was conducted on 60 healthy pregnant Dorper ewes that were divided into two experimental groups: Group 1 (G1), with single pregnancies (n=30), and Group 2 (G2), with twin pregnancies (n=30). Blood samples were collected from all ewes at different times: immediately before fixed-time artificial insemination (AI); on day 30, 90, 120, 130, and 140 of pregnancy; immediately after delivery; and at 24h and 48h postpartum. Statistical analysis compared the two groups at different times (P<0.05). Mild, normocytic, and hypochromic anemia was detected in all ewes from AI time and throughout pregnancy from both groups, but did not prove to be of clinical relevance. In the peripartum stage (from the 140th day of pregnancy to 48h postpartum), the ewes with twin pregnancies (G2) exhibited higher erythrogram values and neutrophil:lymphocyte ratio than did ewes with single pregnancies (G1). This indicated a greater hematopoietic adaptation in the body during the development of two fetuses. Except for the eosinophil numbers, all leukogram parameters were influenced by pregnancy in a similar way in both groups, and was characterized mainly by leukocytosis with neutrophilia during peripartum due to the high presence of endogenous cortisol at delivery. Thus, these findings showed that pregnancy was a stressful physiological event that increased the leukocyte count with a slight alteration in the erythrogram of Dorper ewes.
https://doi.org/10.1590/0103-8478cr20201065
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15.
Discutindo níveis de generalização na gramática de construções baseada no uso: a rede construcional [(x) chegar sn]foc no PB uso x [(x snfoc sn foc
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Freitas Junior, Roberto de
; Nascimento, João Paulo da Silva
; Marques, Priscilla Mouta
; Albernaz, Isabela Maria Gonçalves
.
ABSTRACT The article presents a study on the [(X) CHEGAR SN]FOC taxonomic construction network in Brazilian Portuguese and on the relations maintained between the [(X)VSN]FOC schema, the [(X) CHEGAR SN]FOC subschema and [(X) CHEGAR SN]FOC microconstructions of proper form/meaning characteristics. The research is developed under the Usage-Based Construction Grammar model, associated with Cognitive-Functional Linguistics, an area that defends the emergence of grammar as resulting from language experience and the role of Domain-General Cognitive Processes. We argue in favor of a network representation of [(X) CHEGAR SN]FOC microconstructions with meaning characteristics of presentation of time, event and nonspecific referents. These microconstructions are headed by the subschema [(X) CHEGAR SN]FOC of introductory/presentational meaning which is also headed by the more abstract schema [(X)VSN]FOC that has pragmatic nature strongly associated with informativiness, in particular regarding focus strategies. Thus the article discusses limits and possibilities for the cognitive representation of grammar, in a bottom-up perspective of language acquisition, and is based on the commitment to psychological realism and the limits of categorization. The discussion also touches on the assumptions originated in Perek (2015) about the usage-based valency hypothesis and the emergence of new representations with a higher degree of cognitive accessibility and emancipation. X [(X SNFOC SN FOC XVSNFOC VSN formmeaning form UsageBased Usage Based model CognitiveFunctional Functional Linguistics DomainGeneral Domain General Processes time referents introductorypresentational introductory presentational informativiness strategies bottomup bottom up acquisition categorization 2015 (2015 usagebased usage emancipation 201 (201 20 (20 2 (2 (
RESUMO O artigo apresenta um estudo sobre a rede taxonômica [(X) CHEGAR SN]FOC no Português do Brasil (PB) e as relações de herança mantidas entre o esquema [(X)VSN]FOC, o subesquema [(X) CHEGAR SN]FOC e microconstruções [(X) CHEGAR SN]FOC com propriedwades próprias de forma e sentido. O trabalho se desenvolve a partir do modelo da Gramática de Construções Baseada no Uso (GCBU), associado à Linguística Cognitivo-Funcional, que defende a emergência da gramática como processo resultante da experiência com o uso da língua e da atuação dos Processos Cognitivos de Domínio Geral. Argumentamos a favor de uma representação em rede de microconstruções [(X) CHEGAR SN]FOC - de sentido apresentacional de tempo, evento e referentes inespecíficos -, ligadas ao esquema [(X) CHEGAR SN]FOC - de sentido introdutório/apresentacional -, por sua vez, ligado ao padrão mais abstrato [(X)VSN]FOC - de natureza pragmática fortemente associada à informatividade, em particular à focalização. Assim, o artigo discute limites e possibilidades para a representação cognitiva da gramática, em uma perspectiva bottom-up de aquisição da linguagem, pautando-se no compromisso com o realismo psicológico e os limites da categorização. Ainda, a discussão tangencia os pressupostos apresentados em Perek (2015) acerca da hipótese da valência verbal baseada no uso e da emergência de novas representações de maior grau de emancipação e acessibilidade cognitiva. X [(X SNFOC SN FOC PB (PB XVSNFOC, XVSNFOC VSN FOC, GCBU, GCBU , (GCBU) CognitivoFuncional, CognitivoFuncional Cognitivo Funcional, Funcional Cognitivo-Funcional Geral tempo introdutórioapresentacional introdutório vez informatividade focalização Assim bottomup bottom up linguagem pautandose pautando categorização Ainda 2015 (2015 (GCBU 201 (201 20 (20 2 (2 (
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