ABSTRACT Objective: To determine whether the second-generation constrained condylar prosthesis provided satisfactory results in revision total knee arthroplasty. Methods: A series of 41 cases of revision total knee arthroplasty using the second-generation constrained condylar knee prosthesis was reviewed. The series comprised 7 men and 34 women with a mean age of 73.2 years. The original diagnosis was predominantly osteoarthritis. The most common reason for revision surgery was aseptic loosening. The mean interval between the primary and revision surgeries was 66.4 months. The mean follow-up period was 49.4 months. Results: The mean Knee Society knee score improved from 43.8 to 82.9 after revision surgery, the mean Knee Society function score improved from 37.1 to 79.2; the range of motion improved from 95.6° to 105.6° and the radiological femorotibial alignment improved from 181.4° (varus 6.4°) to 174.9° (valgus 0.1°), on average (p<0.001 at all items). Conclusion: Revision total knee arthroplasty with the use of the second-generation constrained condylar knee prosthesis yielded reproducible clinical success. Level of Evidence IV, Case series.