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Psychosocial factors of patient´s inclusion at ambulatory surgery: scoping review
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Crista, Maria José Silva

; Torres, Paula

; Príncipe, Fernanda

; Mota, Liliana

Millenium - Journal of Education, Technologies, and Health

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apr 2023, N. 20 elocation e27266

Abstract: Es Pt En | Text: Es Pt En | PDF: Es | PDF: Pt | PDF: En

Resumen Introducción: La cirugía ambulatoria tiene criterios de inclusión clínicos y sociales bien definidos. Los factores psicosociales abarcan aspectos de la vida social junto con la psicología clínica interfiriendo en la adherencia a la cirugía ambulatoria. Objetivo: Mapear la evidencia científica sobre los factores psicosociales de inclusión del paciente en cirugía ambulatoria. Métodos: Revisión Scoping realizada seguiendo la metodología JBI e PRISMA-ScR utilizando las bases de datos SCIELO, PUBMED y vía EBSCO a CINHAL Complete, Ebook Nursing Collection, Ebook Collection (Ebsco Host) y MEDLINE utilizando los descriptores “psychosocial factors”, “ambulatory surgery“, “cirurgia ambulatorial” y “enferm*”. Los criterios de inclusión fueron revistas académicas, en inglés, portugués y texto completo y los criterios de exclusión fueron pediatría, artículos duplicados y aquellos que no hicieran referencia en el título a cirugía ambulatoria y factores psicosociales. Dos revisores independientes examinaron y seleccionaron los artículos. Resultados: Se incluyeron en el estudio dos artículos que muestran como factores psicosociales el miedo al dolor, la anestesia, la cirugía, la ansiedad, el malestar, la existencia de un acompañante/cuidador en el domicilio, la vivienda con muchas escaleras, sin ascensor y lejos del hospital y sin transporte. Conclusión: Los aspectos psicológicos y los factores psicosociales contribuyen a la adherencia a este régimen, pero no fue posible identificarlos como factores psicosociales para la inclusión del paciente en cirugía ambulatoria.

Resumo Introdução: A cirurgia ambulatória tem critérios de inclusão clínicos e sociais bem definidos. Os fatores psicossociais abrangem os aspetos da vida social em conjunto com a psicologia clínica interferindo na adesão à cirurgia ambulatória. Objetivo: Mapear a evidência científica sobre fatores psicossociais de inclusão do doente em cirurgia ambulatória. Métodos: Scoping review realizada seguindo a metodologia JBI e PRISMA-ScR recorrendo às bases de dados SCIELO, PUBMED e via EBSCO à CINHAL Complete, Ebook Nursing Collection, Ebook Collection (Ebsco Host) e MEDLINE com recurso aos descritores “psychosocial factors”, “ambulatory surgery“, “cirurgia ambulatorial” e “enferm*”. Os critérios de inclusão foram revistas académicas, inglês, português e texto integral e os de exclusão foram pediatria, artigos duplicados e os que não referiam no título cirurgia ambulatória e fatores psicossociais. A triagem e seleção dos artigos foi realizada por dois revisores independentes. Resultados: Foram incluídos no estudo dois artigos que evidenciam como fatores psicossociais o medo da dor, anestesia, cirurgia, a ansiedade, o desconforto, existência de acompanhante/cuidador no domicílio, habitação com muitas escadas, sem elevador e distante do hospital e não terem transporte. Conclusão: Aspetos psicológicos e necessidades psicossociais contribuem para a adesão a este regime, mas não foi possível identificá-los como fatores psicossociais de inclusão do doente em cirurgia ambulatória.

Abstract Introduction: Ambulatory surgery has well-defined clinical and social inclusion criteria. The psychosocial factors cover aspects of social life together with clinical psychology interfering with adherence to ambulatory surgery. Objective: To map the scientific evidence on psychosocial factors of patient inclusion in ambulatory surgery. Methods: Scoping review conducted following the JBI and PRISMA-ScR methodology using the SCIELO and PUBMED databases and via EBSCO to CINHAL Complete, Ebook Nursing Collection, Ebook Collection (Ebsco Host) and MEDLINE using the descriptors “psychosocial factors”, “ambulatory surgery“, “cirurgia ambulatorial” and “enferm*”. The inclusion criteria were academic journals, English, Portuguese and full text and the exclusion criteria were pediatrics, duplicate articles and those that did not refer in the title ambulatory surgery and psychosocial factors. The screening and selection of articles was performed by two independent reviewers. Results: Two articles were included in the study which highlighted as psychosocial factors the fear of pain, anesthesia, surgery, anxiety, discomfort, the existence of a companion/caregiver at home, living with many stairs, no lift and being far from the hospital and having no transport. Conclusion: Psychological aspects and psychosocial needs contribute to adherence to this regime, but it is not possible to identify them as psychosocial factors of patient`s inclusion in ambulatory surgery.

https://doi.org/10.29352/mill0220.27266

Subjective impacts of computerized cognitive training for healthy older adults in the context of the COVID-19 pandemic
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Viviani, Cristiane Benedita Rodrigues da Mota Antunes

; Ordonez, Tiago Nascimento

; Pereira, Andreia Rodrigues

; Jardim, Karen de Souza

; Borges, Jonatas da Hora

; Mota, Lais Aparecida Pereira

; Santos, Gabriela dos

; Moreira, Ana Paula Bagli

; Verga, Cássia Elisa Rossetto

; Ishibashi, Graciela Akina

; Silva, Guilherme Alves da

; Moraes, Luiz Carlos de

; Lessa, Patrícia Prata

; Gutierrez, Beatriz Aparecida Ozello

; Brucki, Sonia Maria Dozzi

; Silva, Thais Bento Lima da

Arquivos de Neuro-Psiquiatria

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mar 2023, Volume 81 N. 3 Pages 240 - 247

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Antecedentes Programas informatizados de treinamento cognitivo podem ter beneficiado a autoavaliação da memória, a qualidade de vida e o humor entre os idosos durante a pandemia de doença do coronavírus 2019 (coronavirus disease 2019, COVID-19, em inglês). Objetivo Determinar os impactos subjetivos do treinamento cognitivo computadorizado no humor, na frequência de esquecimento, nas queixas de memória, e na qualidade de vida em idosos utilizando uma plataforma online. Métodos Ao todo, 66 idosos participantes do programa USP 60 +, oferecido à terceira idade pela Universidade de São Paulo, e inscritos voluntariamente no estudo, foram selecionados e randomizados em uma razão de 1:1 em 2 grupos: grupo treinamento (n = 33) e grupo controle (n = 33). Após assinarem o termo de consentimento livre e esclarecido, os participantes responderam a um protocolo que incluía um questionário sociodemográfico, o Questionário de Queixas de Memória (Memory Complaints Questionnaire, MAC-Q), A Escala de Frequência de Esquecimento de McNair e Kahn, a Escala de Depressão Geriátrica (Geriatric Depression Scale, GDS-15), o Inventário de Ansiedade Geriátrica (Geriatric Anxiety Inventory, GAI), e –o questionário de Controle, Autonomia, Autorrealização e Prazer (Control, Autonomy, Self-Realization, and Pleasure, CASP-19). A plataforma de jogos cognitivos de treinamento visou estimular diversos aspectos cognitivos, incluindo memória, atenção, linguagem, funções executivas (raciocínio, raciocínio lógico) e habilidades visuais e espaciais. Resultados Na comparação pré e pós-teste, os participantes do grupo de treinamento apresentaram redução nas pontuações do MAC-Q, da escala McNair e Kahn e do GAI. Diferenças significativas entre os grupos quanto às pontuações totais da escala MAC-Q no pós-teste também foram evidenciadas pela regressão logística. Conclusão A participação em uma intervenção cognitiva computadorizada promoveu reduções nas queixas de memória, frequência de esquecimento e sintomas de ansiedade, além de melhorar a qualidade de vida autorrelatada.

Abstract Background Computerized cognitive training programs may have benefited the self-assessment of memory, quality of life, and mood among older adults during the coronavirus disease 2019 (COVID-19) pandemic. Objective To determine the subjective impacts of computerized cognitive training on mood, frequency of forgetfulness, memory complaints, and quality of life in the elderly using an online platform. Methods In total, 66 elderly participants of USP 60 +, a program for the elderly offered by Universidade de São Paulo, who voluntarily enrolled in the study were selected and randomized with an allocation ratio of 1:1 into 2 groups: the training group (n = 33) and the control group (n = 33). After signing the free and informed consent form, they answered a protocol which included a sociodemographic questionnaire, the Memory Complaints Questionnaire (MAC-Q), the McNair and Kahn’s Frequency of Forgetfulness Scale, the Geriatric Depression Scale (GDS-15), the Geriatric Anxiety Inventory (GAI), and the Control, Autonomy, Self-Realization, and Pleasure (CASP-19) questionnaire. The training cognitive game platform aimed to stimulate various cognitive aspects, including memory, attention, language, executive functions (reasoning, logical thinking), and visual and spatial skills. Results The participants of the training group showed a reduction in the MAC-Q, MacNair and Kahn, and GAI scores in the pre- and posttest comparison. Significant differences were identified between the groups regarding the total scores of the MAC-Q in the post-test, which was also evidenced by the logistic regression. Conclusion Participation in a computerized cognitive intervention promoted reductions in memory complaints, frequency of forgetfulness, and anxiety symptoms, in addition to improving self-reported quality of life.

https://doi.org/10.1055/s-0043-1767823

Hipertensão em mulheres presas no Brasil: muito além do biológico
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Silva, Paula Negrão da

; Kendall, Carl

; Silva, Ana Zaira da

; Mota, Rosa Maria Salani

; Araújo, Larissa Fortunato

; Pires Neto, Roberto da Justa

; Leal Júnior, Francisco Marto Pinheiro

; Macena, Raimunda Hermelinda Maia

; Kerr, Ligia Regina Franco Sansigolo

Ciência & Saúde Coletiva

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jan 2023, Volume 28 N. 1 Pages 37 - 48

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Objetivou-se estimar a prevalência de hipertensão arterial (HA) e os fatores de risco associados em mulheres presas. Utilizou-se dados do Inquérito Nacional de Saúde na População Penitenciária Feminina e em Servidoras Prisionais, investigando-se características sociodemográficas, fatores das prisões, comportamentos e condições de saúde. As informações foram coletadas por meio de questionário autoaplicado, sendo a magnitude da associação estimada por odds ratio e intervalo de confiança de 95%. Das 1.327 participantes, 24,4% eram hipertensas, a maioria tinha 31 anos ou mais (54,6%), 51,5% autorreferiram etnia/cor parda. Após mutual ajustamento pelos fatores de risco associados na análise bivariada, observou-se relação direta e com gradiente entre idade e HA, em que idade igual/maior a 41 anos foi associada independentemente com uma chance sete vezes maior de ter HA, se comparado a quem tem menos de 25 anos. Aquelas que autorreferiram etnia/cor negra apresentaram colesterol alto e estavam obesas, também foram associadas de forma independente com maior prevalência de HA. O maior número de pessoas com que a presa divide cela esteve associado à maior prevalência de há, sem uma relação dose-resposta. Conclui-se que idade, etnia/cor, obesidade, inatividade física e estresse são fatores de risco para HA em mulheres presas.

Abstract The scope was to estimate the prevalence of arterial hypertension (AHT) and associated risk factors among female prisoners. Data from the National Health Survey of the Female Prison Population and Prison Guards were used, investigating sociodemographic variables, prison characteristics, health behaviors and conditions. Information was collected through a self-administered questionnaire, and the magnitude of the association was estimated by the odds ratio and 95% confidence interval. Of the 1,327 prisoner participants, 24.4% were hypertensive, the majority were 31 years of age or older (54.6%), and 51.5% self-reported mixed race. After adjustment for associated risk factors in the bivariate analysis, a direct relationship between age and AHT was observed, in which age equal to/over 41 years was independently associated with a 7-fold greater chance of having AHT, compared to those under 25 years of age. Those who self-reported mixed race, had high cholesterol, were obese and were also independently associated with a higher prevalence of AHT. The greater the number of people with whom the inmate shares a cell was associated with a higher prevalence of AHT, but without a dose-response relationship. The conclusion drawn is that age, race, obesity, physical inactivity and stress are risk factors for AHT in female prisoners.

https://doi.org/10.1590/1413-81232023281.10672022

Hipertensão em mulheres presas no Brasil: muito além do biológico
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Silva, Paula Negrão da

; Kendall, Carl

; Silva, Ana Zaira da

; Mota, Rosa Maria Salani

; Araújo, Larissa Fortunato

; Pires Neto, Roberto da Justa

; Leal Júnior, Francisco Marto Pinheiro

; Macena, Raimunda Hermelinda Maia

; Kerr, Ligia Regina Franco Sansigolo

Ciência & Saúde Coletiva

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jan 2023, Volume 28 N. 1 Pages 37 - 48

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

https://doi.org/10.1590/1413-81232023281.10672022

Wort disinfection treatment with electron beam for bioethanol production
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Calegari, Rubens Perez

; Silva, Eric Alberto da

; Silva, Ana Paula Maria da

; Gomes, Marcelo Pego

; Mota, Layna Amorim

; Arthur, Valter

; Baptista, Antonio Sampaio

Scientia Agricola

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2023, Volume 80 elocation e20210260

Abstract: En | Text: En | PDF: En

ABSTRACT Microbial contamination of the wort during the fermentation process causes significant losses in ethanol production worldwide and creates a dependence of the industry on chemicals and antibiotics to control contamination. Therefore, this study used electron beam (e-beam) to disinfect wort from sugarcane (Saccharum officinarum L.) molasses and investigate the bioethanol fermentation. Four treatments (T0 – T3) were carried out using ionizing doses of radiation through the electron accelerator: 0 (control), 10, 20, and 40 kGy. Total mesophiles, total bacteria, sucrose, glucose, fructose, phenolics, flavonoids, hydroxymethylfurfural (5-HMF), and Furfural were measured. An alcoholic fermentation assay was performed after the irradiation process. The irradiated treatments showed no inversion of sugars and formation of the inhibitory by-products flavonoids, furfural and 5-HMF, except for the phenolic compounds. The lower dose tested (10 kGy) reduced more than 99.9 % of the total mesophiles and more than 99.99 % of the total bacteria in the substrate. In the fermentation, the irradiated worts presented similar (p > 0.05) yields (92, 93, and 94 %) and ethanol productivity levels (0.89, 0.88, and 0.87 g L–1 h–1, for T1, T2, and T3 respectively). However, all treatments presented higher yields and productivity (p < 0.05) when compared to the control (88 % and 0.85 g L–1 h–1), highlighting the possible use of e-beam in wort fermentation at a lower dose (10 kGy). This allows reduction in losses caused by microbial contamination, besides increasing fermentation yield and productivity with lower energy consumption.

https://doi.org/10.1590/1678-992x-2021-0260

Phenotypic and genotypic characterization of oxacillin-susceptible and mecA positive Staphylococcus aureus strains isolated in Uruguay
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Pardo, Lorena

; Giudice, Guillermina

; Mota, María Inés

; Gutiérrez, Claudia

; Varela, Adriana

; Algorta, Gabriela

; Seija, Verónica

; Galiana, Antonio

; Aguerrebere, Paula

; Klein, Mónica

; Varela, Gustavo

Revista argentina de microbiología

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dec 2022, Volume 54 N. 4 Pages 101 - 110

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

Abstract The aim of this study was to characterize phenotypically and genotypically 27 mecApositive Staphylococcus aureus strains with oxacillin MICs of ≤2 g/ml by Vitek 2, isolated indifferent regions of Uruguay. Susceptibility to oxacillin and cefoxitin was studied by gradient dif-fusion, disk diffusion to cefoxitin, and Phoenix and MicroScan systems. PBP2a was determined.SCCmec typing was performed and the isolates were compared by PFGE. Twenty-six isolateswere susceptible to oxacillin; one strain was susceptible to cefoxitin by disk diffusion and 3strains by gradient diffusion. Phoenix and MicroScan panels detected methicillin resistance in25 and 27 strains, respectively. Twenty-six strains tested positive for PBP2a. Twenty-six strainscarried SCCmec V and 24 belonged to pulsotype A. One strain carried SCCmec IV and did notbelong to pulsotype A. Cefoxitin disk diffusion test and PBP2a detection correctly identified 26of these 27 strains as MRSA. PFGE results suggest the dissemination of a cluster of MRSA carryingSCCmec V.

Resumen El objetivo de este estudio fue caracterizar fenotípicamente y genotípicamente 27 cepas de Staphylococcus aureus positivas para mecA y con CIM de oxacilina <2 pg/ml según Vitek 2, obtenidas en diferentes regiones del país. La sensibilidad frente a la oxacilina y la cefoxitina se estudió por difusión en gradiente, por disco-difusión (cefoxitina) y por los sistemas Phoenix y MicroScan. Se analizó la portación de PBP2a, se realizó la tipificación de SCCmec y las cepas se compararon mediante PFGE. Resultaron sensibles a oxacilina por difusión en gradiente 26 cepas; una fue sensible a cefoxitina por disco-difusión y 3 lo fueron por difusión en gradiente. Los sistemas Phoenix y MicroScan detectaron resistencia a meticilina en 25 y 27 cepas, respectivamente. Asimismo, 26 cepas portaban PBP2a y 26 cepas mostraron presencia de SCCmec V, 24 correspondieron al pulsotipo A. Una portaba SCCmec IV y no perteneció al pulsotipo A. La prueba de disco-difusión con cefoxitina y la detección de PBP2a identificaron 26 de 27 cepas como MRSA. La PFGE sugiere la diseminación de un grupo MRSA con SCCmec V. © 2022 Asociación Argentina de Microbiología. Publicado por Elsevier Espana, S.L.U. Este es un artículo Open Access bajo la licencia CC BY-NC-ND (https://creativecommons.org/licenses/by-nc-nd/4.0/).

https://doi.org/10.1016/j.ram.2022.05.004

Estudo do esgoto de um município do sul de Minas Gerais: correlação de variáveis físicas e químicas, casos de COVID-19 e concentração do RNA de SARS-CoV-2
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Abreu, Mariana Aparecida de Freitas

; Siqueira, Juliano Curi de

; Souza, Aline dos Reis

; Ázara, Marina Santos

; Lopes, Bruna Coelho

; Mota Filho, César Rossas

; Batista, Ana Maria Moreira

; Assemany, Paula Peixoto

; Franco, Camila Silva

; Matos, Mateus Pimentel de

; Silva Filho, Marcelo Vieira da

; Siniscalchi, Luciene Alves Batista

Engenharia Sanitaria e Ambiental

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oct 2022, Volume 27 N. 5 Pages 967 - 974

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO A epidemiologia baseada em esgotos é uma importante ferramenta de saúde pública com grande aplicabilidade no enfrentamento à pandemia de COVID-19, visto que indivíduos infectados são capazes de excretar partículas de SARS-CoV-2. Diante desse contexto, este estudo objetivou correlacionar o número de casos de COVID-19 com variáveis físicas e químicas e presença do vírus em amostras de esgoto bruto provenientes de uma estação de tratamento de esgoto (ETE) do município de Lavras (MG) coletadas entre as 19ª e 25ª semanas epidemiológicas. As amostras foram concentradas pelo método de adsorção em membrana eletronegativa, e o RNA de SARS-CoV-2 foi extraído, detectado e quantificado por reação da transcriptase reversa seguida pela reação em cadeia da polimerase (RT-qPCR) utilizando-se oligonucleotídeos e sondas para o gene N. Ademais, as variáveis pH, sólidos suspensos totais e demanda química de oxigênio foram avaliadas. Os casos de COVID-19 foram obtidos de boletins epidemiológicos disponibilizados pela prefeitura. Na 24ª semana epidemiológica, observou-se redução na concentração viral (cópias L-1) concomitantemente às medidas de enfrentamento à pandemia iniciadas pelo município. Correlação positiva forte e significativa (p < 0,05) entre carga viral e número de casos confirmados foi obtida por meio do teste de Spearman, entretanto não houve correlação entre a presença do vírus e as características físicas e químicas do esgoto. Sugere-se, portanto, que novas pesquisas sejam realizadas com a finalidade de rastrear a concentração de SARS-CoV-2 em águas residuárias, corroborando, desse modo, com o enfrentamento à pandemia e a obtenção de sistemas de vigilância epidemiológica por meio do monitoramento de esgotos.

ABSTRACT Wastewater-based epidemiology is an important public health tool with great applicability when facing the COVID-19 pandemic, since infected individuals are able to excrete SARS-CoV-2 particles. In this context, this study aimed to correlate the number of cases of COVID-19 with physical and chemical variables and the presence of the virus in raw sewage samples from a sewage treatment plant (STP) in the municipality of Lavras, Minas Gerais, Brazil, collected between the 19th and 25th epidemiological weeks. The samples were concentrated by electronegative membrane adsorption method and SARS-CoV-2 RNA was extracted, detected, and quantified by RT-qPCR using oligonucleotides and probes for the N gene. Moreover, the variables pH, total suspended solids, and chemical oxygen demand were evaluated. COVID-19 cases were obtained from epidemiological bulletins made available by the municipal government. From the 24th epidemiological week on, a reduction in viral concentration (copies L-1) was observed concomitantly with the pandemic response countermeasures initiated by the municipality. A strong and significant positive correlation (p<0.05) between viral load and number of confirmed cases was obtained through Spearman’s test. However, there was no correlation between the presence of the virus and the physical and chemical characteristics of the sewage. Therefore, it is suggested that further research be carried out in order to track SARS-CoV-2 concentrations in wastewater, thus corroborating with the fight against the pandemic and the achievement of epidemiological surveillance systems based on sewage monitoring.

https://doi.org/10.1590/s1413-415220220006

Desmoplastic fibroblastoma (collagenous fibroma) on the mandibular ridge: case report and review of immunohistochemical markers
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Isaias, Pedro Henrique Chaves

; Bezerra, Thâmara Manoela Marinho

; Chaves, Filipe Nobre

; Alves, Ana Paula Negreiros Nunes

; Pereira, Karuza Maria Alves

; Mota, Mário Rogério Lima

Revista Portuguesa de Estomatologia, Medicina Dentária e Cirurgia Maxilofacial

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mar 2022, Volume 63 N. 1 Pages 52 - 57

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo O fibroblastoma desmoplásico (FD) é um tumor benigno raro de partes moles de origem fibroblástica e miofibroblástica e sua ocorrência na cavidade oral é rara. Este estudo detalha um novo caso de uma lesão elevada no rebordo alveolar de uma mulher de 59 anos, dolorosa à mastigação. O exame histopatológico mostrou proliferação de células de morfologia fusiformes a estreladas, não encapsulada, em um estroma rico em colagénio e hipocelular. As células tumorais foram forte e difusamente positivas para vimentina e algumas células foram focalmente positivas para α-actina do músculo liso, CD99 e β-catenina. Os exames foram conclusivos para o diagnóstico de FD. O paciente está no período de acompanhamento e nenhuma lesão recorrente foi detetada em um ano. O FD descrito neste relato, apesar de apresentar características clínico-patológicas-imuno-histoquímicas semelhantes aos casos descritos anteriormente, é apresentado em um local oral incomum e associado a sintomatologia dolorosa. A imuno-histoquímica é uma ferramenta importante nos casos de FD nos quais o exame histopatológico não é conclusivo.

Abstract The desmoplastic fibroblastoma (DF) is a rare benign soft-tissue tumor of fibroblastic and myofibroblastic origin, and its occurrence in the oral cavity is rare. This study details a new case of an elevated lesion in the alveolar ridge of a 59-year-old woman, painful during mastication. The histopathological exam showed non-encapsulated stellate-to-spindle cells proliferation in a hypocellular collagen-rich stroma. Tumor cells were strongly and diffusely positive for vimentin, and some cells were focally positive for α-smooth muscle actin, CD99, and β-catenin. The exams were conclusive for DF diagnosis. The patient is in the follow-up period, and no recurrent lesions were detected within one year. Despite having similar clinical, pathological, and immunohistochemical features to the cases previously described, the DF in this report is at an unusual oral site and associated with painful symptomatology. Immunohistochemistry is an important tool in DF cases where the histopathological examination is not conclusive.

https://doi.org/10.24873/j.rpemd.2022.01.859 12 downloads

Technical performance of a lateral flow immunoassay for detection of anti-SARS-CoV-2 IgG in the outpatient follow-up of non-severe cases and at different times after vaccination: comparison with enzyme and chemiluminescent immunoassays
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Barreira, Gabriel Acca

; Santos, Emilly Henrique dos

; Pereira, Maria Fernanda Bádue

; Rodrigues, Karen Alessandra

; Rocha, Mussya Cisotto

; Kanunfre, Kelly Aparecida

; Marques, Heloisa Helena de Sousa

; Okay, Thelma Suely

; Eisencraft, Adriana Pasmanik

; Rossi Junior, Alfio

; Fante, Alice Lima

; Cora, Aline Pivetta

; Costa Reis, Amelia Gorete A. de

; Ferrer, Ana Paula Scoleze

; Andrade, Anarella Penha Meirelles de

; Watanabe, Andreia

; Gonçalves, Angelina Maria Freire

; Waetge, Aurora Rosaria Pagliara

; Silva, Camila Altenfelder

; Ceneviva, Carina

; Lazari, Carolina dos Santos

; Abellan, Deipara Monteiro

; Sabino, Ester Cerdeira

; Bianchini, Fabíola Roberta Marim

; Alcantara, Flávio Ferraz de Paes

; Ramos, Gabriel Frizzo

; Leal, Gabriela Nunes

; Rodriguez, Isadora Souza

; Pinho, João Renato Rebello

; Carneiro, Jorge David Avaizoglou

; Paz, Jose Albino

; Ferreira, Juliana Carvalho

; Ferranti, Juliana Ferreira

; Ferreira, Juliana de Oliveira Achili

; Framil, Juliana Valéria de Souza

; Silva, Katia Regina da

; Bastos, Karina Lucio de Medeiros

; Galleti, Karine Vusberg

; Cristofani, Lilian Maria

; Suzuki, Lisa

; Campos, Lucia Maria Arruda

; Perondi, Maria Beatriz de Moliterno

; Diniz, Maria de Fatima Rodrigues

; Fonseca, Maria Fernanda Mota

; Cordon, Mariana Nutti de Almeida

; Pissolato, Mariana

; Peres, Marina Silva

; Garanito, Marlene Pereira

; Imamura, Marta

; Dorna, Mayra de Barros

; Luglio, Michele

; Aikawa, Nadia Emi

; Degaspare, Natalia Viu

; Sakita, Neusa Keico

; Udsen, Nicole Lee

; Scudeller, Paula Gobi

; Gaiolla, Paula Vieira de Vincenzi

; Severini, Rafael da Silva Giannasi

; Rodrigues, Regina Maria

; Toma, Ricardo Katsuya

; Paula, Ricardo Iunis Citrangulo de

; Palmeira, Patricia

; Forsait, Silvana

; Farhat, Sylvia Costa Lima

; Sakano, Tânia Miyuki Shimoda

; Koch, Vera Hermina Kalika

; Cobello Junior, Vilson

Revista do Instituto de Medicina Tropical de São Paulo

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2022, Volume 64 elocation e49

Abstract: En | Text: En | PDF: En

ABSTRACT This study assessed the technical performance of a rapid lateral flow immunochromatographic assay (LFIA) for the detection of anti-SARS-CoV-2 IgG and compared LFIA results with chemiluminescent immunoassay (CLIA) results and an in-house enzyme immunoassay (EIA). To this end, a total of 216 whole blood or serum samples from three groups were analyzed: the first group was composed of 68 true negative cases corresponding to blood bank donors, healthy young volunteers, and eight pediatric patients diagnosed with other coronavirus infections. The serum samples from these participants were obtained and stored in a pre-COVID-19 period, thus they were not expected to have COVID-19. In the second group of true positive cases, we chose to replace natural cases of COVID-19 by 96 participants who were expected to have produced anti-SARS-CoV-2 IgG antibodies 30-60 days after the vaccine booster dose. The serum samples were collected on the same day that LFIA were tested either by EIA or CLIA. The third study group was composed of 52 participants (12 adults and 40 children) who did or did not have anti-SARS-CoV-2 IgG antibodies due to specific clinical scenarios. The 12 adults had been vaccinated more than seven months before LFIA testing, and the 40 children had non-severe COVID-19 diagnosed using RT-PCR during the acute phase of infection. They were referred for outpatient follow-up and during this period the serum samples were collected and tested by CLIA and LFIA. All tests were performed by the same healthcare operator and there was no variation of LFIA results when tests were performed on finger prick whole blood or serum samples, so that results were grouped for analysis. LFIA’s sensitivity in detecting anti-SARS-CoV-2 IgG antibodies was 90%, specificity 97.6%, efficiency 93%, PPV 98.3%, NPV 86.6%, and likelihood ratio for a positive or a negative result were 37.5 and 0.01 respectively. There was a good agreement (Kappa index of 0.677) between LFIA results and serological (EIA or CLIA) results. In conclusion, LFIA analyzed in this study showed a good technical performance and agreement with reference serological assays (EIA or CLIA), therefore it can be recommended for use in the outpatient follow-up of non-severe cases of COVID-19 and to assess anti-SARS-CoV-2 IgG antibody production induced by vaccination and the antibodies decrease over time. However, LFIAs should be confirmed by using reference serological assays whenever possible.

https://doi.org/10.1590/s1678-9946202264049

10.

PESQUISAS SOBRE IMPLEMENTAÇÃO DE POLÍTICAS EDUCACIONAIS NO BRASIL: UM ESTADO DO CONHECIMENTO
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COCK, JULIANA CRISTINA ARAUJO DO NASCIMENTO

; NASCIMENTO, ALDENIRA MOTA DO

; COSTA, PAULA ARAUJO

; BONAMINO, ALICIA MARIA CATALANO DE

Educação em Revista

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2022, Volume 38 elocation e26769

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

RESUMO: Apresentamos os resultados de um estudo de revisão do tipo estado do conhecimento de pesquisas sobre a implementação de políticas e programas educacionais publicadas no Brasil em periódicos do campo temático de Políticas Públicas. Duas questões nortearam os objetivos específicos deste mapeamento: se as políticas e os programas educacionais têm se constituído como objeto de pesquisa dos estudos de implementação do campo de Políticas Públicas e quais as principais abordagens utilizadas pelos pesquisadores da área nessas investigações. Trata-se de um trabalho documental e bibliográfico, constituído por um levantamento dos artigos publicados em periódicos nacionais qualificados no estrato A1 do Qualis Periódicos (Capes) nas áreas do conhecimento Ciência Política, Sociologia e Administração Pública. Os principais resultados apontam que, apesar de ainda pouco analisada, se comparada às políticas da área da saúde e da assistência social, a implementação de políticas e programas educacionais tem crescido dentre os objetos de pesquisa do campo de Políticas Públicas. Apontam também uma dupla tendência entre esses estudos: aqueles que são produzidos vinculados aos referenciais teóricos e conceituais do campo de Políticas Públicas e outros que não demonstram uma interface do ponto de vista teórico-conceitual com esse campo.

ABSTRACT: We present the data of a state of knowledge review study over research on the implementation of educational policies and programs published in Brazilian Public Policy journals. Two questions conducted the particular goals of this analysis: whether educational policies and programs have been represented as research objects in studies of implementation in the field of Public Policies and what the main approaches are used by researchers in the area during these investigations. This is a documentary and bibliographic work, comprising a survey of articles published in national journals qualified in the A1 class of Qualis Periodicals (Capes) in the areas of Political Science, Sociology, and Public Administration. The main results indicate that, although still poorly studied, when compared to policies in the area of health and social assistance, the implementation of educational policies and programs has grown among the objects of research in the field of Public Policies. Results also indicate two inclinations among these studies: those that are produced while tied to theoretical and conceptual references in the field of Public Policy and others that do not present interaction with this field, from the theoretical-conceptual point of view.

RESUMEN: Presentamos los resultados de un estudio de revisión de tipo estado de conocimiento sobre la implementación de políticas y programas educativos publicados en Brasil en revistas del campo temático de Políticas Públicas. Dos preguntas orientadoras fueron los objetivos específicos de este mapeo: si las políticas y programas educativos se han constituido como objetos de investigación en los estudios de implementación en el campo de las Políticas Públicas y cuáles son los principales enfoques utilizados por los investigadores del área en estas investigaciones. Es un trabajo documental y bibliográfico centrado en un solo sector de publicaciones. Se realizó un levantamiento de artículos publicados en revistas nacionales calificadas en el estrato A1 de Qualis Periódicos (Capes) en las áreas de Ciencia Política, Sociología y Administración Pública. Los principales resultados señalan que, si bien todavía está poco analizado, en comparación con las políticas de salud y asistencia social, la implementación de políticas y programas educativos ha crecido entre los objetos de investigación en el campo de las Políticas Públicas. También señalan una doble tendencia entre estos estudios: aquellos que se producen vinculados a referentes teóricos y conceptuales en el campo de las Políticas Públicas y otros que no demuestran una interfaz desde el punto de vista teórico-conceptual con este campo.

https://doi.org/10.1590/0102-4698368526769

11.

Rituximab therapy for childhood onset idiopathic nephrotic syndrome: experience of a Portuguese tertiary center
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Gomes, Rita

; Mosca, Sara

; Bastos-Gomes, Mariana

; Correia-Costa, Liane

; Rocha, Liliana

; Teixeira, Ana

; Costa, Teresa

; Sameiro-Faria, Maria

; Matos, Paula

; Mota, Conceição

Brazilian Journal of Nephrology

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2022, N. ahead

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Introdução: Rituximabe (RTX) é uma opção terapêutica na síndrome nefrótica (SN) idiopática pediátrica de difícil tratamento. Visamos avaliar eficácia e segurança do uso de RTX nestes pacientes. Método: Realizou-se estudo retrospectivo de todos os pacientes com SN idiopática tratados com RTX, em uma unidade de nefrologia pediátrica de um hospital terciário. Dados demográficos, antropométricos, clínicos e analíticos foram coletados antes do tratamento e aos 6, 12 e 24 meses. Resultados: Incluímos 16 pacientes (11 do sexo masculino), com idade mediana (percentil 25–75, P25–P75) de 2 (2,0–2,8) anos ao diagnóstico. Quinze eram sensíveis a esteroides, e 1 resistente a esteroides e sensível à ciclosporina.A idade mediana na administração do RTX foi 10 (6,3–14,0) anos. Durante um tempo mediano de acompanhamento de 2,5(1,0–3,0) anos, 6 (37,5%) pacientes alcançaram remissão parcial e 7 (43,8%) não tiveram recidivas e não estavam tomando imunossupressor no acompanhamento aos 24 meses. Quanto às complicações,1 paciente apresentou hipogamaglobulinemia persistente. Comparado ao período de12 meses anterior ao RTX, houve diminuição no número mediano de recidivas em 6 e 12 meses [3 (3,0–4,0) vs 0 (0–0,8) e 0,50 (0–1,0), respectivamente; p = 0,001] e na dose diária de esteroides (mg/kg/dia) aos 6, 12 e 24 meses [0,29 (0,15–0,67) >vs [0,10 (0,07–0,13); p = 0,001], [0,12 (0,05–0,22); p = 0,005] e [0,07 (0,04–0,18); p = 0,021], respectivamente. Houve também redução na mediana do escore z do IMC aos 24 meses [2,11 (0,45–3,70) vs 2,93 (2,01–3,98);p = 0,049]. Conclusões: Nossos resultados confirmam a eficácia e segurança do uso de RTX em SN idiopática pediátrica, destacando seus potenciais benefícios cardiometabólicos.

ABSTRACT Introduction: Rituximab (RTX) is a therapeutic option in pediatric difficult-to-treat idiopathic nephrotic syndrome (NS). We aimed to assess the efficacy and safety of RTX use in these patients. Method: A retrospective study of all patients with idiopathic NS treated with RTX was conducted in a pediatric nephrology division of a tertiary hospital. Demographic, anthropometric, clinical and analytical data were collected prior to treatment and at 6, 12, and 24 months. Results: Sixteen patients were included (11 males), with a median (25th–75th percentile, P25–P75) age at diagnosis of 2 (2.0–2.8) years. Fifteen were steroid-sensitive and 1 was steroid-resistant and sensitive to cyclosporine. The median age at administration of RTX was 10 (6.3–14.0) years. Throughout a median follow-up time of 2.5 (1.0–3.0) years, 6 (37.5%) patients achieved partial remission and 7 (43.8%) had no relapses and were not taking any immunosuppressants at the 24-month follow-up visit. Regarding complications, 1 patient presented persistent hypogammaglobulinemia. Compared with the 12-month period before RTX, there was a decrease in the median number of relapses at 6 and 12 months [3 (3.0–4.0) vs 0 (0–0.8) and 0.50 (0–1.0), respectively; p = 0.001] and in the daily steroids dose (mg/kg/day) at 6, 12, and 24 months [0.29 (0.15–0.67)vs [0.10 (0.07–0.13); p = 0.001], [0.12 (0.05–0.22); p = 0.005] and [0.07(0.04–0.18); p = 0.021]], respectively. There was also a reduction in the median BMI z score at 24 months [2.11 (0.45–3.70) vs. 2.93 (2.01–3.98); p = 0.049]. Conclusion: Our results confirm the efficacy and safety of RTX use in pediatric idiopathic NS and highlight its’ potential cardiometabolic benefits.

https://doi.org/10.1590/2175-8239-jbn-2022-0056en

12.

Evaluation of respiratory complications in a cohort of preterm infants who did not receive palivizumab monoclonal antibodies
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Bonati, Poliana Castro de Resende

; Furtado, Maria Cândida de Carvalho

; Mello, Débora Falleiros de

; Wolkers, Paula Carolina Bejo

; Faria, Gabriel de Oliveira

; Ferreira, Daniela Marques de Lima Mota

Revista Brasileira de Enfermagem

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2022, Volume 75 N. 6 elocation e20210362

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

RESUMO Objetivos: investigar intercorrências respiratórias no primeiro ano de vida de prematuros não contemplados com anticorpo monoclonal palivizumabe. Métodos: estudo de coorte retrospectivo, analítico, com prematuros nascidos entre 2012 e 2016, em Uberlândia, MG. Coleta realizada de janeiro a novembro de 2018, em prontuários hospitalar e da atenção básica. Utilizou-se modelo de regressão de Poisson; considerou-se p<0.05. Resultados: de 5.213 nascimentos prematuros, 504 (9,7%) atenderam os critérios; esses prematuros tiveram 2.899 atendimentos na atenção básica; 1.098 (37,5%) com diagnóstico médico, 803 (78,5%) do trato respiratório. Prematuros com fórmula láctea na alta hospitalar tiveram mais diagnósticos de doenças respiratórias. Idade materna (p=0,039), diagnóstico respiratório na alta (p=0,028), número de consultas eventuais (p<0,001) apresentaram associação significativa com bronquiolite. Consultas eventuais foram significantes para doenças respiratórias; o aleitamento materno mostrou-se protetor para bronquiolite. Conclusões: prematuros sem palivizumabe apresentaram elevado percentual de doenças respiratórias; observou-se efeito protetor do aleitamento materno. Recomenda-se vigilância desses prematuros na atenção primária.

ABSTRACT Objectives: to analyze the occurrence of respiratory complications over the first year of life in preterm infants who did not receive palivizumab monoclonal antibodies. Methods: analytical retrospective cohort study with preterm infants born between 2012 and 2016 in Uberlândia, state of Minas Gerais, Brazil. Data collection occurred from January to November 2018, by consulting hospital and primary healthcare medical records. Data were processed with the Poisson regression model, with p<0.05. Results: of a total of 5,213 preterm births, 504 (9.7%) met the inclusion criteria. The preterm infants in this subset were assisted 2,899 times in primary care, which resulted in 1,098 (37.5%) medical diagnoses, of which 803 (78.5%) involved the respiratory tract. Preterm babies fed on formula milk at hospital discharge had more diagnoses of respiratory diseases. Maternal age (p=0.039), respiratory diagnosis at hospital discharge (p=0.028), and number of sporadic appointments (p<0.001) showed a significant association with bronchiolitis; number of sporadic appointments showed a significant association with occurrence of respiratory diseases; and breastfeeding had a protective effect against the development of bronchiolitis. Conclusions: preterm infants who did not receive palivizumab showed a high percentage of respiratory diseases, and breastfeeding helped protect them against bronchiolitis. It is recommended that these preterm babies be monitored in primary health care.

RESUMEN Objetivos: investigar complicaciones respiratorias en el primer año de vida de prematuros no contemplados con anticuerpo monoclonal palivizumab. Métodos: estudio de cohorte retrospectivo, analítico, con prematuros nacidos entre 2012 y 2016 en Uberlândia, MG. Datos recolectados de enero a noviembre de 2018 en historias clínicas hospitalarias y de atención básica. Se utilizó modelo de regresión de Poisson, considerándose p<0,05. Resultados: de 5.513 nacimientos prematuros, 504 (9,7%) atendieron criterios; estos prematuros recibieron 2.899 consultas en atención básica; 1.098 (37,5%) con diagnóstico médico; 803 (78,5%) del tracto respiratorio. Prematuros con fórmula láctea al alta hospitalaria recibieron más diagnósticos de enfermedades respiratorias. Edad materna (p=0,039), diagnóstico respiratorio al alta (p=0,028), cantidad de consultas eventuales (p<0,001) mostraron asociación significativa con bronquiolitis. Conclusiones: prematuros sin palivizumab mostraron elevado porcentaje de enfermedades respiratorias; se observó efecto protector de la lactancia materna. Se recomienda el seguimiento de dichos prematuros en atención primaria.

https://doi.org/10.1590/0034-7167-2021-0362

13.

Factors associated with hospitalizations for Covid-19 in patients with rheumatoid arthritis: data from the Reumacov Brazil registry
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Gomides, Ana Paula Monteiro

; Albuquerque, Cleandro Pires de

; Mota, Licia Maria Henrique da

; Devidé, Guilherme

; Dias, Laiza Hombre

; Duarte, Angela Luzia Branco Pinto

; Giovelli, Raquel Altoé

; Karnopp, Thais Evelyn

; Lima, Hugo Deleon de

; Marinho, Adriana

; Oliveira, Marianne Schrader de

; Omura, Felipe

; Ranzolin, Aline

; Resende, Gustavo

; Ribeiro, Francinne Machado

; Ribeiro, Sandra Lúcia Euzébio

; Sacilotto, Nathália de Carvalho

; Santos, Wander Gonzaga dos

; Shinjo, Samuel Katsuyuki

; Studart, Samia Araujo de Sousa

; Teixeira, Flávia Patricia Sena

; Yazbek, Michel Alexandre

; Ferreira, Gilda Aparecida

; Monticielo, Odirlei A.

; Paiva, Eduardo

; Pileggi, Gecilmara Cristina Salviato

; Reis Neto, Edgard Torres dos

; Pinheiro, Marcelo de Medeiros

; Marques, Claudia D. L.

Advances in Rheumatology

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2022, Volume 62 elocation 13

Abstract: En | Text: En | PDF: En

Abstract Background: Patients using immunosuppressive drugs may have unfavorable results after infections. However, there is a lack of information regarding COVID 19 in these patients, especially in patients with rheumatoid arthritis (RA). Therefore, the aim of this study was to evaluate the risk factors associated with COVID 19 hospitalizations in patients with RA. Methods: This multicenter, prospective cohort study is within the ReumaCoV Brazil registry and included 489 patients with RA. In this context, 269 patients who tested positive for COVID 19 were compared to 220 patients who tested negative for COVID 19 (control group). All patient data were collected from the Research Electronic Data Capture database. Results: The participants were predominantly female (90.6%) with a mean age of 53 ±12 years. Of the patients with COVID 19, 54 (20.1%) required hospitalization. After multiple adjustments, the final regression model showed that heart disease (OR =4.61, 95% CI 1.06–20.02. P < 0.001) and current use of glucocorticoids (OR =20.66, 95% CI 3.09–138. P < 0.002) were the risk factors associated with hospitalization. In addition, anosmia was associated with a lower chance of hospitalization (OR =0.26; 95% CI 0.10–0.67, P < 0.005). Conclusion: Our results demonstrated that heart disease and the use of glucocorticoids were associated with a higher number of hospital admissions for COVID 19 in patients with RA. Trial registration: Brazilian Registry of Clinical Trials RBR 33YTQC.

https://doi.org/10.1186/s42358-022-00244-5

14.

Cecropia pachystachya Trécul: a promising ingredient for skin-whitening cosmetics
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Freitas, Pedro Henrique Santos de

; Conegundes, Jéssica Leiras Mota

; Evangelista, Monique de Rezende

; Almeida, Maycon Alcântara de

; Silva, Natália Prado da

; Tavares, Guilherme Diniz

; Vilela, Fernanda Maria Pinto

; Duque, Ana Paula do Nascimento

; Ribeiro, Antônia

; Scio, Elita

Brazilian Journal of Pharmaceutical Sciences

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2022, Volume 58 elocation e21154

Abstract: En | Text: En | PDF: En

Abstract Because it promotes the lightening of pigment spots, tyrosinase inhibition is one of the mechanisms of depigmenting cosmetic products. Considering the adverse effects produced by synthetic depigmenting actives, the search for new therapeutic options is desirable, and plant extracts are possible candidates for hyperpigmentation treatment. Glycolic extracts of Cecropia pachystachya Trécul are, therefore, the focus of this study. Its chemical characterization, antioxidant activity, tyrosinase inhibition, and cell viability were evaluated. Glycolic extracts were obtained by macerating the leaves of C. pachystachya in grain alcohol and glycerin or propylene glycol. Both had a similar chemical constitution, the glycerin being more efficient in concentrating phenolic compounds and flavonoids. Analyses by UHPLC-MS detected quinic acid, chlorogenic acid isomers, proanthocyanidin dimers type B and C, catechin/epicatechin, orientin/isoorientin, isoorientin 2”-O-xyloside, vitexin/isovitexin, and rutin. 5-O-caffeoylquinic acid was then quantified was then quantified, with predominance in the extract produced with propylene glycol. These extracts showed a high antioxidant capacity by the method of DPPH, β-carotene, and nitric oxide. As for depigmenting activity, both extracts were able to inhibit tyrosinase. Cell viability assay also revealed that the extracts could safely be used in concentrations of ≤ 125 µg/mL. Thus, this study demonstrated for the first time that the glycolic extracts of C. pachystachya have promising chemical and biological characteristics for the development of a multifunctional cosmetic with antioxidant and tyrosinase-inhibition activities.

https://doi.org/10.1590/s2175-97902022e21154

15.

Suitability of donata and BRS F 132 cultivar for the potato processing industry
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PEREIRA, Ariana Mota

; GOMES, Mateus de Paula

; GUIMARÃES, Maria Eduarda da Silva

; CRUZ, Renata Ranielly Pedroza

; GALDINO, Antonia Gorete da Silva

; FREIRE, Ana Izabella

; RIBEIRO, Wellington Souto

; FINGER, Fernando Luiz

Food Science and Technology

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2022, Volume 42 elocation e65820

Abstract: En | Text: En | PDF: En

Abstract Changes in the population's eating habits have expanded the French fries market. However, the need for refrigerated storage to supply sprouts and maintain a constant supply to the industry has led to a reduced number of cultivars suitable for processing due to the accumulation of sugars and browning after frying. Because of this, the objective of this study was to evaluate the suitability of the Donata and BRS F132 cultivars for use in the pre-fried potato processing industry. The tubers were stored at 6 and 8 °C for up to 180 days and the analysis of sprouting, total soluble sugar (TSS), reducing sugar (RS), non-reducing sugar (NRS), post-frying color by scale visual color used by the industry and L* and b* parameters. The sprouting was higher at 8 °C and in the BRS F 132 cultivar. The sugar content was high in both cultivars, however, the color remained adequate. It is concluded that the Donata and BRS F132 cultivars are suitable for the potato processing industry, and Donata presented better quality parameters. Conditioning at 8 °C is recommended in both cultivars that maintained the quality for 180 days.

https://doi.org/10.1590/fst.65820

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