Abstract Obesity and depression, disorders associated with inflammation, have high incidences in women. Understanding the derangements present in the initial phase of obesity may point to factors that could help avoiding disease aggravation. The present study aimed at investigating the effects of a 6-months interdisciplinary therapy for weight loss in women with grade I obesity. Before and after the therapy, 37 middle-aged women donated blood and responded to questionnaires for depression and anxiety symptoms. Inflammatory parameters were evaluated in serum and a preliminary screening of the plasma proteome was performed. The therapy decreased anthropometric, psychological scores, and serum levels of inflammatory parameters. Depression and anxiety scores correlated positively with some inflammatory parameters. The proteomic analysis showed changes in proteins related to cholesterol metabolism and inflammatory response. Interdisciplinary therapy improves anthropometric and inflammatory statuses and ameliorating psychological symptoms. The decrease of MCP-1 levels after interdisciplinary therapy has not been reported so far, at the best of our knowledge. The present demonstration of positive associations of inflammatory markers and psychological scores indicate that these mediators may be useful to monitor psychological status in obesity. The present proteome data, although preliminary, pointed to plasma alterations indicative of improvement of inflammation after interdisciplinary therapy.

Um total de 103 espécimes de Hoplias intermedius (Günther, 1864) e 86 de H. malabaricus (Bloch, 1794), provenientes do alto Rio São Francisco, Estado de Minas Gerais, foram coletados entre abril de 2011 e agosto de 2013 e tiveram sua fauna parasitária investigada. Quatro espécies de digenéticos foram encontradas: metacercárias de Austrodiplostomum sp. e de Ithyoclinostomum sp.; e espécimes adultos de Phyllodistomum spatula Odhner, 1902 e de Pseudosellacotyla lutzi (Freitas, 1941) Yamaguti, 1954. A prevalência das metacercárias foi mais elevada do que as registradas para os digenéticos adultos dos eritrinídeos do alto Rio São Francisco, resultante da dieta preferencialmente piscívora desses peixes adultos. A presença de metacercárias e de espécimes adultos de digenéticos indicam que os peixes atuam como hospedeiros intermediários e definitivos, respectivamente, nos seus ciclos biológicos. Hoplias intermedius constitui novo hospedeiro para as quatro espécies de Digenea encontradas e a bacia do Rio São Francisco constitui uma nova localidade para a distribuição geográfica conhecida de P. spatula e de P. lutzi.

A total of 103 specimens of Hoplias intermedius (Günther, 1864) and 86 specimens of H. malabaricus (Bloch, 1794) from the upper São Francisco River, State of Minas Gerais were collected between April 2011 and August 2013, and their parasitic fauna were investigated. Four species of Digenea were found: metacercariae of Austrodiplostomum sp., and Ithyoclinostomum sp.; and adult specimens of Phyllodistomum spatula Odhner, 1902, and Pseudosellacotyla lutzi (Freitas, 1941) Yamaguti, 1954. The prevalence of the metacercariae was higher than that of the adult digeneans of erythrinids from the upper São Francisco River as a result of piscivorous feeding habits of these adult erythrinids. The presence of metacercariae and adult digeneans indicate that they act as intermediate and definitive hosts, respectively, in their biological cycles. Hoplias intermedius is a new host for the four species of Digenea, and the São Francisco River basin is a new location for the known geographical distributions of P. spatula and P. lutzi.