Objective: The objective of the study was to describe the demographic and clinical characteristics found in personnel screened during the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic. Materials and methods: Nasal and oropharyngeal swab samples were collected in the period between May 11 and May 26, 2020, from 496 people. They were followed up by means of a questionnaire at 0, 7, and 14 days. Results: 449 people answered the surveys (73 excluded); age range: 21-63 years, mean of 39.4 years. About 77% had contact with patients with coronavirus infection, (32% had an exposure time of < 8 h a week, 24% 8-16 h a week and 20% more than 16 h a week). The most frequent comorbidity in the population was obesity (13.8%), followed by asthma (8%) and DM2 (1%). The most common symptom was headache (34%), followed by nasal obstruction (25%) and odynophagia in third place (22%); 16% presented alterations in the perception of odors. Among the surveyed personnel, 17 (4.5%) tested positive for SARS-COV2 by means of reverse transcription polymerase chain reaction. Conclusions: In line with this pandemic, a screening protocol was started for asymptomatic health-care personnel for the recognition of infections caused by this virus to establish barriers that will prevent the spread and provide the basis for the standardization of this practice and the protection of health-care personnel.

ABSTRACT Technological advances for biogas generation have allowed to revalue the poultry litter as it is a source of biomass with a high energy content. In this work was realized the potential study of the Poultry Litter Industry of the Sancti Spiritus province as a feasible treatment of it wastes. Physical-chemical characterization, biogas potential determination and the electrical and thermal power form poultry litter was carried out. The volatile solids were within the range reported by the literature for replacement and laying hen manure, being 44, 20 % and 43, 09 % and it was estimated that 8178m3 of biogas can be generated daily, which would represent a production between 6656 MWh of electrical energy and 9 641 MWh of thermal energy per year, which would largely support the energy of the demand of poultry farms.

RESUMEN Los avances de las tecnologías para la generación de biogás han permitido revalorizar a la gallinaza por su alto contenido energético. En este trabajo se realizó el estudio del potencial energético de la Empresa Avícola de la provincia Sancti Spíritus, como una alternativa factible para el tratamiento de sus residuales. Se realizó la caracterización físico-química de la gallinaza y la determinación del potencial de biogás y la potencia eléctrica y térmica que se puede generar a partir de la misma. Los sólidos volátiles estuvieron dentro del rango reportado por la literatura para la gallinaza de reemplazo y ponedora, siendo de 44,20 % y 43,09 % respectivamente. Se estimó que se pueden generar diariamente 8 178 m3 de biogás, que representarían una producción entre 6 656 MWh de energía eléctrica y 9 641 MWh de energía térmica al año, lo que puede sustentar en gran medida la demanda energética de las granjas avícolas.

Carbon-supported platinum-iridium nanowire-shape electrocatalysts containing 20% of metallic loading were synthesized by chemical reduction method using formic acid as a reducing agent and tested towards the oxidation of ethanol in acidic medium. The developed electrocatalysts were synthesized with the following compositions: Pt0.9Ir0.1/C, Pt0.8Ir0.2/C, Pt0.7Ir0.3/C, Pt0.6Ir0.4/C and Pt0.5Ir0.5/C using for comparison the commercial Pt/C Alfa Aesar catalyst. Physico-chemical characterization was performed using X-ray diffraction (XRD), transmission electron microscopy (TEM), and X-ray fluorescence (XRF, for chemical composition) techniques. All the nanowires present a face-centered cubic crystalline structure of the platinum with modifications in the lattice parameter due to the inclusion of iridium. The XRF analyzes show that the theoretical compositions of the synthesized catalysts are very close to the experimental nominal values. TEM analyses showed the formation of nanowires by the synthesis method used. The electrochemical results on the oxidation of ethanol show that the addition of a second metal to the platinum in the composition of the nanowires increases the catalytic activity of the electrode. The nanowire catalysts with low Ir content (Pt0.9Ir0.1/C, Pt0.8Ir0.2/C, Pt0.7Ir0.3/C) present the best outcomes under the analyzed conditions and are promising for application as anodes in direct ethanol fuel cells.

Ferulic acid (FERH) is known to exert leishmanicidal action against Leishmania (Leishmania) amazonensis. In this study, the ferulate anion (FER–) was intercalated into a layered double hydroxide (LDH) for FER– delivery during an antileishmania in vitro test. The LDH-FER– intercalation compound was prepared by coprecipitation and was characterized by X-ray powder diffraction, thermogravimetry, UV-Vis, infrared, and Raman spectroscopy analyses. Leishmania (L.) amazonensisin vitro assays were conducted to assess the LDH-FER– potential. LDH-FER– was found to promote a dose-dependent reduction of L. (L.) amazonensis amastigotes (intracellular form, half maximal inhibitory concentration (IC50) = 1.78 µg mL-1) without exerting a deleterious effect on the host macrophages (medium cytotoxic concentration (CC50) = 212.61 µg mL-1 and selectivity index = 119.4). LDH-FER– was found to be an effective inhibitor of the amastigote form of L. (L.) amazonensis, suggesting that LDH-FER– was able to deliver FER– inside the parasitophorous vacuoles where the pH is more acidic.

Abstract Inhaled therapy is considered the cornerstone of asthma treatment. However, despite being the ideal form of drug delivery, it is recognized that only 70% of patients have an adequate attachment to their treatment and only 39-67% of physicians can explain the optimal inhaler technique. Inhaled therapy has very specific characteristics. Pulmonary deposit of an inhaled medication through the respiratory tract is more complex than when administered orally and depends on several factors inherent to both the medication and the administration. For successful inhaled therapy, the drug needs to be converted into particles of an appropriate size, which can enter beyond the oropharynx and larynx, and be deposited in the lungs. There are multiple devices for the administration of drugs in the lower respiratory tract, each one with a similar efficacy as long as it is used with the correct technique. The decision of which device should be used is made based on the age of the patient, the ability to coordinate between the inhalation and activation of the device, and the presence of acute symptoms. The choice of the device must be evaluated individually.

Resumen La terapia inhalada se considera la piedra angular del manejo del asma. Sin embargo, a pesar de ser la forma ideal de administración de estos medicamentos, solamente el 70% de los pacientes cumple el tratamiento adecuadamente y sólo del 39 al 67% de los médicos conocen y pueden explicar de forma adecuada las distintas técnicas de inhalación. La terapia inhalada tiene características muy particulares. El depósito pulmonar de un medicamento inhalado a través del tracto respiratorio es más complejo que cuando se administra por vía oral, y varía dependiendo de varios factores, tanto inherentes al medicamento como a la forma de administrarlo. Para que la terapia inhalada sea exitosa, se requiere que se generen partículas del medicamento de un tamaño apropiado que penetren más allá de la orofaringe y la laringe, y que puedan depositarse en los pulmones. Existen múltiples dispositivos para la administración de medicamentos en la vía respiratoria baja. Cada uno ha probado tener una eficacia similar, siempre y cuando se utilicen con la técnica correcta. La decisión para su uso se realiza con base en la edad del paciente, la capacidad de coordinar entre la inhalación y la activación del dispositivo y la presencia de síntomas agudos. La elección del dispositivo a utilizar siempre deberá hacerse de forma conjunta, evaluando pros y contras de cada uno de los dispositivos y siempre de forma individualizada.

RESUMO: No Brasil, segundo o Programa Nacional de Controle e Erradicação da Brucelose e Tuberculose Animal (PNCEBT), do Ministério da Agricultura, Pecuária e Abastecimento (MAPA), os testes de rotina para o diagnóstico de tuberculose bovina são o teste cervical simples (TCC), o teste da prega caudal (TPC) e o teste cervical comparativo (TCC), sendo que o último também é utilizado como teste confirmatório. Um grupo de 53 animais oriundos de três rebanhos leiteiros de área de foco para tuberculose bovina que foram submetidos a vazio sanitário no Rio Grande do Sul foi submetido ao TCC. Os tecidos destes animais foram cultivados e as colônias resultantes confirmadas por PCR e sequenciamento de DNA. Dos 53 animais analisados no TCC, 32 (60,4%) foram negativos, 14 (26,4%) positivos e sete (13,2%) inconclusivos, com base no PNCEBT. O TCC detectou como positivos 11 dos 39 animais com infecção por M. bovis confirmada por cultivo. Do total de 14 animais não infectados, baseado na cultura, o TCC detectou oito como negativos. Assim, o TCC apresentou, para a população amostrada, sensibilidade de 28,2% e especificidade de 57,1%. Um total de 24/32 (75,0%) dos animais negativos ao TCC foi positivo no cultivo (confirmado por PCR), sendo considerados falso-negativos ao TCC. A manutenção destes animais falso-negativos nos rebanhos tem sérias implicações para o controle da enfermidade, já que os mesmos podem ser fonte de infecção. A adição de testes complementares poderia auxiliar na identificação destes animais, aumentando a cobertura diagnóstica.

ABSTRACT: According to the Brazilian National Program for the Control and Eradication of Animal Brucellosis and Tuberculosis (PNCEBT), the routine tests for the diagnosis of bovine tuberculosis in the country are the simple intradermal tuberculin test (SITT) of the Ministry of Agriculture, Livestock and Food Supply (MAPA), the caudal fold test and the comparative intradermal tuberculin test (CITT). The latter is also used as a confirmatory test. A group of 53 animals from three dairy herds in a focal area for bovine tuberculosis, that were submitted to depopulation in the state of Rio Grande do Sul, were submitted to the CITT. Tissues were cultured and the resulting colonies were confirmed by PCR and DNA sequencing. Among the 53 animals analyzed using the CITT, 32 (60.4%) were negative, 14 (26.4%) were positive and seven (13.2%) results were inconclusive. The CITT detected 11 of the 39 animals with culture-confirmed M. bovis infection as positive. Among the total of 14 uninfected animals based on cultures, the CBT detected eight as negative. Thus, the CITT demonstrated sensitivity of 28.2% and specificity of 57.1% for the population sampled. A total of 24/32 (75.0%) of the animals with negative CITT results were culture positive (confirmed by PCR) and were considered false negatives based on the CITT. The maintenance of these false-negative animals in herds has serious implications for the control of the disease, since they can be a source of infection. The addition of complementary tests could help identify such animals and increase the odds of diagnostic success.

Objective: The aims of this study were to describe the incidence of obesity and overweight in critically ill cancer patients, and to evaluate the clinical characteristics and Intensive Care Unit (ICU) outcomes of critically ill cancer patients with obesity and overweight. Methods: An observational cohort study. There were no interventions. Results: During the study period, 483 critically ill cancer patients were admitted to ICU, and 59.2% of them (258 patients) had high body mass index (BMI). Comparing the groups of patients with BMI < 25 kg/m² and ≥ 25 kg/m², we observed that those with BMI ≥ 25 kg/m² were older at the time of admission to the ICU. The global mortality in ICU was of 22.4%. ICU mortality was similar between patients with BMI < 25 kg/m² and ≥ 25 kg/m² (21.3% versus 23.0%, p = 0.649). Univariate analysis indicated that the following five factors were associated with ICU death in patients with BMI ≥ 25 kg/m² as the outcome variable of interest: age, sepsis, invasive mechanical ventilation, type 2 diabetes, ≥ two organ failures. Multivariate analysis identified ≥ two organ failures as independent prognostic factor of ICU death. Conclusion: Critically ill cancer patients have a high incidence of high BMI; approximately six of every ten patients admitted to the ICU with a serious condition are overweight or show several degrees of obesity. The ICU mortality of the patients with a body mass index < 25 kg/m² and ≥ 25 kg/m² was similar. The independent prognostic factor of ICU death in critically ill patients with a BMI ≥ 25 kg/m² was the number of organ dysfunctions, especially when two or more organs were affected.

Objetivo: Describir la incidencia de obesidad y sobrepeso en pacientes graves con cáncer y evaluar las características clínicas y el pronóstico de los pacientes oncológicos gravemente enfermos con sobrepeso y obesidad. Métodos: Estudio observacional y descriptivo. No se realizó ninguna intervención. Resultados: Durante el periodo de estudio, 483 pacientes graves con cáncer fueron ingresados a la unidad de cuidados intensivos (UCI); el 59.2% (258 pacientes) tuvo índice de masa corporal (IMC) elevado. Al comparar los pacientes con IMC < 25 kg/m² y con IMC ≥ 25 kg/m², se observó que los pacientes con IMC ≥ 25 kg/m² eran de mayor edad al momento de ingresar en la UCI. La mortalidad en la UCI fue del 22.4%. La mortalidad fue similar en los grupos con IMC < 25 kg/m² y ≥ 25 kg/m² (21.3% versus 23.0%, p = 0.649). El análisis multivariado determinó que las siguientes variables fueron asociadas con muerte en la UCI en el grupo de pacientes con IMC ≥ 25 kg/m²: edad, sepsis, ventilación mecánica invasiva, diabetes mellitus tipo 2 y cursar con dos o más fallas orgánicas. El análisis multivariado identificó como factor pronóstico independiente para muerte en la UCI cursar con dos o más fallas orgánicas. Conclusión: los pacientes graves con cáncer tienen una alta incidencia de IMC elevado; aproximadamente seis de cada diez pacientes ingresados en la UCI con una condición que pone en peligro la vida tienen sobrepeso o son obesos. La mortalidad fue similar en los grupos con IMC < 25 kg/m² y ≥ 25 kg/m². En el grupo de pacientes con IMC ≥ 25 kg/m² se identificó como factor pronóstico independiente para muerte en UCI el número de fallas orgánicas especialmente cuando dos o más órganos están afectados.

Resumo O presente estudo avalia a influência da anestesia sobre a fauna parasitária de monogeneas em peixes, sua intensidade e sua viabilidade. Dois experimentos foram realizados: Avaliação de um método anestésico por aspersão eugenol diretamente nas brânquias e avaliação da motilidade das monogeneas e sua viabilidade; e Comparação entre imersão e aspersão diretamente nas brânquias com benzocaína e eugenol, seguido de avaliação sobre a intensidade parasitária. Os resultados sugerem que a aspersão do anestésico não interferiu na motilidade, morfologia, superfície corporal e integridade do parasita, analisadas pelo método de fluorescência. A intensidade de monogenéticos nas brânquias foi menor nos peixes anestesiados pelo método de imersão em comparação com o método de aspersão e o grupo controle. O método de anestesia por aspersão nas brânquias pode ser utilizado em estudos parasitológicos.

Abstract The present study evaluates the influence of anesthesia on the parasitic fauna of monogenea fish parasites, as its intensity and viability. Two experiments were conducted: Evaluation of an anesthetic method by sprinkling eugenol directly on gills and evaluation of monogenea motility and viability; Comparison of immersion and directly sprinkling on the gills with benzocaine and eugenol followed by evaluation on parasite intensity. The results suggest that the anesthetic sprinkling didn’t interfere in the parasite motility, morphology and body surface integrity analyzed by fluorescence method. The monogenean intensity in the gills was lower in fish anesthetized by immersion method compared to the sprinkling method and the control group. This method of anesthesia can be used in parasitological studies.

Resumo: Ao realizar estudos sobre corrosão em concreto armado, é importante considerar nos ensaios a ação de cargas externas, pois esta situação é mais frequente nas estruturas. Neste artigo apresentam-se os resultados obtidos ao expor vigas de concreto armado a um processo de corrosão acelerada, submetidas a esforços de flexão materializados com cargas que geram tensões constantes de tração nas armaduras corroídas. As vigas foram elaboradas com diferentes espessuras de cobrimento das armaduras e com um concreto de resistência característica de 25MPa. Este estudo coloca em evidência a influência da espessura de cobrimento das armaduras, sobre o processo de corrosão e sua manifestação externa (fissuração do cobrimento), frente às mesmas solicitações mecânicas.

Abstract: When carrying out corrosion studies on reinforced concrete, it is important to consider the action of external loads in the tests, as this situation is the most frequent in the structures. In this work, we show the results obtained from exposing beams of reinforced concrete subjected to flexional effects, materialized with loads that generate equal tensile stress on the corroded reinforcement, to an accelerated corrosion process. The beams were manufactured with different coating thicknesses on the reinforcement and with a concrete of 25 MPa characteristic resistance. This study evidences the influence of the coating thickness of the reinforcement on the corrosion process and its external manifestation (cracking of the coating), compared with the same mechanical requests.

Resumen: Al realizar estudios sobre corrosión en hormigón armado, es importante considerar en los ensayos, la acción de cargas externas, pues esta situación es la más frecuente en las estructuras. En este trabajo, se presentan los resultados obtenidos al exponer a un proceso de corrosión acelerada, a vigas de hormigón armado sometidas a esfuerzos flexionales, materializados con cargas, que generan iguales tensiones de tracción en las armaduras corroídas. Las vigas se fabricaron con diferentes espesores de recubrimiento de las armaduras y con un hormigón de resistencia característica 25 MPa. Este estudio pone en evidencia la influencia del espesor de recubrimiento de las armaduras, sobre el proceso de corrosión y su manifestación externa (fisuración del recubrimiento), frente a las mismas solicitaciones mecánicas.

RESUMOForam utilizadas 31 vacas leiteiras mestiças para comparar o perfil energético em duas estações, verão e inverno. Amostras de sangue foram colhidas semanalmente durante o pré-parto, no dia do parto e nos dias dois, cinco, 10, 15, 21 e 30 do pós-parto. Todos os metabólitos analisados foram influenciados pelo estádio fisiológico. As concentrações de glicose foram maiores no inverno, enquanto as concentrações de triglicérides e lactato desidrogenase (LDH) foram maiores no verão. As concentrações de colesterol, AST e GGT mostraram um padrão de comportamento diferente entre o verão e o inverno. Ácidos graxos não esterificados (NEFA) e beta-hidroxibutirato (BHB) não foram influenciados pela estação do ano. As vacas que pariram durante o inverno tinham um escore de condição corporal (ECC) maior e perderam mais ECC até o parto. No verão, 32,26% e, no inverno, 29,03% dos animais apresentaram concentrações de NEFA acima do recomendado no pré-parto; 22,58% dos animais no verão e 19,35% no inverno tiveram cetose subclínica em algum momento do período de transição, tornando-os mais suscetíveis a outras doenças.

ABSTRACTWe used 31 crossbreed dairy cows to compare the energetic profile in summer and winter. Blood samples were taken weekly prepartum, at calving and on days 2, 5, 10, 15, 21 and 30 postpartum. All metabolic indicators analyzed were influenced by the physiological status. The glucose concentrations were higher during winter while the triglyceride concentrations and lactate dehydrogenase (LDH) were higher in the summer. The season influenced the concentrations of cholesterol, AST and GGT, showing a different pattern between summer and winter. Non-esterified fatty acids (NEFA) and beta-hidroxibutirate (BHB) were not influenced by the season. Cows that calved during winter had a greater body condition score (BCS) and lost more BCS until calving. During summer, 32.26% of the animals and 29.03% during winter had NEFA concentrations above the optimum level and 22.58% of the animals in summer and 19.35% in the winter had subclinical ketosis at some point during the transition period, making then more susceptible to diseases.

In the region of Los Tuxtlas, Veracruz, a Network for Institutional and Organizational Articulation (Red de Articulación Institucional y Organizacional, RAIO) was formed to improve the relationships of collaboration, cooperation and ssociation between institutions and organizations involved in a proposal of institutional intervention that dealt with the carce technological innovation in the economic and social evelopment of small-scale hillside farmers, with the agroecologic technology of milpa interspersed with fruit trees (MIAF, for its initials in Spanish), promoted with participatory strategies in order to improve knowledge and comprehension mong producers, and to become the basis for innovation in the face of conditions that complicate its transference, such as scarce inter-institutional coordination. Institutions were invited to ntegrate the RAIO, an essential part of the proposal, generating ew levels of relationship among them. With the social network analysis (SNA), relationship structures were compared in two moments, "before the proposal" and "with the proposal", to dentify actors and the ties generated. It is concluded that the RAIO was integrated by eight institutional actors that promoted development and natural resource conservation, structured as a emporary network that strengthened the relationships between ctors and generated synergies to improve family production systems, and that the management of innovations for economic and social development of the rural sector in Los Tuxtlas is a complex process socially, institutionally and organizationally.

En la región de Los Tuxtlas, Veracruz se formó una Red de Articulación Institucional y Organizacional (RAIO) para mejorar relaciones de colaboración, cooperación y asociación entre instituciones y organizaciones involucradas en una propuesta de intervención institucional, que atendió la escasa innovación tecnológica en el desarrollo económico y social de pequeños agricultores de ladera, con la tecnología agroecológica milpa intercalada en árboles frutales (MIAF), promovida con estrategias participativas para fortalecer su conocimiento y comprensión en productores, y ser base para la innovación ante condiciones que dificultan su transferencia, como la escasa coordinación interinstitucional. Se convocó a instituciones pata integrar la RAIO, parte fundamental de la propuesta, generando nuevos niveles de relación entre ellas. Con el análisis de redes sociales (ARS) se compararon estructuras relacionales en dos momentos, "antes de la propuesta" y "con la propuesta", para identificar actores y vínculos generados. Se concluye que la RAIO está integrada por ocho actores institucionales que promueven desarrollo y conservación de recursos naturales, estructurada como red temporal que potenció relaciones entre actores y generó sinergias para mejorar sistemas de producción familiar, y que la gestión de innovaciones pata el desarrollo económico y social del sector rural de Los Tuxtlas es un proceso social, institucional y organizacionalmente complejo.

OBJETIVO: Estimar a frequência de história pregressa de chiado, descrevendo as características clínicas e formas de tratamento utilizadas. MÉTODOS: Coorte retrospectiva incluindo lactentes (6-23 meses de vida) com sintomas de infecção de vias aéreas superiores e relato de episódio prévio de chiado. Os dados foram registrados em questionário anteriormente validado. RESULTADOS: Dos 451 avaliados, 164 (36,4%; IC95% = 31,9-41,0) apresentaram história pregressa de chiado, 148 (32,8%; IC95% = 28,5-37,4) no primeiro ano de vida. A média de idade no primeiro episódio de chiado foi de 5,3±3,9 meses. Para quem começou a chiar no primeiro ano de vida, 38,5% referiram entre três e seis episódios e 14,2% > seis episódios. A média da idade no primeiro episódio foi menor para os que apresentaram > três episódios em comparação aos que apresentaram até dois episódios (3,2±2,7 versus 5,7±2,5 meses, p < 0,001). CONCLUSÃO: Um terço dos lactentes apresentou chiado no primeiro ano de vida. Quanto mais cedo ocorre o primeiro episódio, mais frequente é a recorrência do chiado.

OBJECTIVE: To estimate the frequency and describe the clinical characteristics and respective treatments of previous history of wheezing. METHODS: Infants aged 6-23 months with upper respiratory tract complaints and reporting previous wheezing were followed-up retrospectively. Data were registered on a validated standardized form. RESULTS: Out of 451 infants, 164 (36.4%; 95%CI: 31.9-41.0) had a report of prior history of wheezing, 148 (32.8%; 95%CI: 28.5-37.4) during the first year of life. The mean age at the first episode of wheezing was 5.3±3.9 months. Among those who had had their first episode before 12 months of age, 38.5% reported 3 to 6 episodes and 14.2% > 6 episodes. Mean age at first episode was lower for those with > 3 episodes in comparison with those with < 2 episodes (3.2±2.7 vs. 5.7±2.5 months, p < 0.001). CONCLUSION: One third of the infants reported wheezing during the first year of life. The earlier the first episode occurs, the more frequently wheezing recurs.

Low cardiac output syndrome is a potential complication in cardiac surgery patients and is associated with increased morbidity and mortality. This guide provides recommendations for the management of these patients, immediately after surgery and following admission to the ICU. The recommendations are grouped into different sections, addressing from the most basic concepts such as definition of the disorder to the different sections of basic and advanced monitoring, and culminating with the complex management of this syndrome. We propose an algorithm for initial management, as well as two others for ventricular failure (predominantly left or right). Most of the recommendations are based on expert consensus, due to the lack of randomized trials of adequate design and sample size in patients of this kind. The quality of evidence and strength of the recommendations were based on the GRADE methodology. The guide is presented as a list of recommendations (with the level of evidence for each recommendation) for each question on the selected topic. For each question, justification of the recommendations is then provided.

El síndrome de bajo gasto cardiaco es una potencial complicación de los pacientes intervenidos de cirugía cardiaca y asocia un aumento de la morbimortalidad. La presente guía pretende proporcionar recomendaciones para el manejo de estos pacientes, en el postoperatorio inmediato, ingresados en UCI. Las recomendaciones se han agrupado en diferentes apartados, tratando de dar respuesta desde los conceptos más básicos como es la definición a los diferentes apartados de monitorización básica y avanzada, y terminando con el complejo manejo de este síndrome. Se propone un algoritmo de manejo inicial, así como otros de fracaso ventricular predominantemente izquierdo o derecho. La mayor parte de las recomendaciones están basadas en el consenso de expertos, debido a la falta de estudios clínicos aleatorizados, de adecuado diseño y tamaño muestral en este grupo de pacientes. La calidad de la evidencia y la fuerza de las recomendaciones se realizó siguiendo la metodología GRADE. La guía se presenta como una lista de recomendaciones (y nivel de evidencia de cada recomendación) para cada pregunta del tema seleccionado. A continuación, en cada pregunta, se procede a la justificación de las recomendaciones.

By describing 3 clinical cases of unusual testicular non germinal tumors, including an adenoma of the rete testis, an undifferenciated sex cord tumor and a mesothelioma of the tunica vaginalis, we make a literature review of the unusual testicular tumors and testicular apendix, including their incidence and management. Also and as one of our conclusions, we expose the importance of the intraoperatory biopsy in the testicular cancer surgery, because even if it is infrecuent, the presence of this rare testicular tumors, in which if they are proven to be benign, the testicular unit could be preserved and the radical orquiectomy could be avoided.

A propósito de tres casos clínicos con tumores de histología infrecuente del testículo que incluyen el adenoma de la rete testis, el tumor indiferenciado de los cordones sexuales y el mesotelioma de la túnica vaginal, se realiza una revisión bibliográfica de los tumores inusuales del testículo y sus anexos, incluyendo su incidencia y manejo. Finalmente y a manera de conclusión, se explica la importancia de la biopsia rápida en el caso de los tumores testiculares dado que, aunque infrecuente, si ésta resultara benigna, podría evitarse la orquectomía radical y realizar una cirugía conservadora.

In this study we sintered NaSbO3 compound at 860 °C from Na2CO3 and Sb2O3, detailed structural and microstructural of the compound were studied. Refinement of the X-ray diffraction (XRD) patterns by method of Rietveld indicate that the crystal structure of NaSbO3 belongs to the trigonal system with hexagonal symmetry, space group R3‾(No.148), lattice parameters a = 5.2944(4) Å, c = 15.9469(8) Å and volume V = 387.124(0) ų with Z = 6. Scanning electron microscopy (SEM) analysis displayed that sintered samples at temperatures lower than 750 °C have a favorable effect on the homogeneity of the samples.