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BACKGROUND Chikungunya is a mosquito-borne virus that has been causing large outbreaks in the Americas since 2014. In Brazil, Asian-Caribbean (AC) and East-Central-South-African (ECSA) genotypes have been detected and lead to large outbreaks in several Brazilian states. In Rio Grande do Sul (RS), the southernmost state of Brazil, the first cases were reported in 2016. OBJECTIVES AND METHODS We employed genome sequencing and epidemiological investigation to characterise the Chikungunya fever (CHIKF) burden in RS between 2017-2021. FINDINGS We detected an increasing CHIKF burden linked to travel associated introductions and communitary transmission of distinct lineages of the ECSA genotype during this period. MAIN CONCLUSIONS Until 2020, CHIKV introductions were most travel associated and transmission was limited. Then, in 2021, the largest outbreak occurred in the state associated with the introduction of a new ECSA lineage. CHIKV outbreaks are likely to occur in the near future due to abundant competent vectors and a susceptible population, exposing more than 11 million inhabitants to an increasing infection risk.

https://doi.org/10.1590/0074-02760220259

Teste de Limiar de Desfibrilação e Seguimento a Longo Prazo de Pacientes com Cardiopatia Crônica da Doença de Chagas
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Campos, Marco Paulo Cunha

; Bernardes, Luiz Fernando Gouveia

; Melo, João Paulo Chaves de

; Santos, Lucas Corsino dos

; Teixeira, Cristiano Honório Ribeiro

; Pavão, Maria Licia Ribeiro Cury

; Arfelli, Elerson

; Scorzoni Filho, Adilson

; Rassi Jr, Anis

; Marin-Neto, José A.

; Schmidt, André

Arquivos Brasileiros de Cardiologia

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dec 2022, Volume 119 N. 6 Pages 923 - 928

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Fundamento A morte súbita cardíaca (MSC) é a causa mais comum de óbito na cardiomiopatia crônica da doença de Chagas (CCDC). Visto que muitos pacientes com CCDC que são candidatos a receber um cardioversor desfibrilador implantável (CDI) atendem a critérios que sugerem alto risco de apresentarem limiares de desfibrilação elevados, sugere-se realizar um teste de limite de desfibrilação (LDF). Objetivos Investigamos o uso do teste de LDF em pacientes com CCDC, com enfoque nos óbitos relacionados ao implante do CDI e na ocorrência de eventos arrítmicos e o tratamento oferecido durante o seguimento de longo prazo. Métodos Avaliações retrospectivas de 133 pacientes com CCDC que receberam CDI, principalmente para prevenção secundária. Foram coletados dados demográficos, clínicos e laboratoriais, escore de Rassi e dados do teste de LDF. Adotou-se p<0,05 como estatisticamente significativo. Resultados A média de idade foi 61±13 anos, e 72% da amostra era do sexo masculino. A fração de ejeção basal do ventrículo esquerdo foi 40±15%, e o escore de Rassi médio foi 10±4 pontos. Não ocorreram óbitos durante o teste de LDF, e não foram documentadas falhas do CDI. Foi identificada relação entre escore de Rassi basal mais elevado e LDFs mais elevados (ANOVA =0,007). O tempo médio até o primeiro choque foi de 474±628 dias, mas a aplicação de choque foi necessária em apenas 28 (35%) pacientes com TV, visto que a maioria dos casos se resolveu espontaneamente ou através da programação de ATP. Após seguimento clínico de 1728±1189 dias, em média, ocorreram 43 óbitos, relacionados principalmente a insuficiência cardíaca progressiva e sepse. Conclusões Um teste de LDF de rotina pode não ser necessário para pacientes com CCDCs que receberam CDI para prevenção secundária. LDFs elevados parecem ser incomuns e podem estar relacionados a escore de Rassi elevado.

Abstract Background Sudden cardiac death is the most common cause of death in chronic Chagas cardiomyopathy (CCC). Because most CCC patients who are candidates for implantable cardioverter-defibrillators (ICD) meet criteria for high defibrillation threshold values, a defibrillator threshold test (DTT) is suggested. Objectives We investigated the use of DTT in CCC patients, focusing on deaths related to ICD and arrhythmic events, as well as treatment during long-term follow-up. Methods We retrospectively evaluated 133 CCC patients who received an ICD mainly for secondary prevention. Demographic, clinical, laboratory data, Rassi score, and DTT data were collected, with p < 0.05 considered significant. Results The mean patient age was 61 (SD, 13) years and 72% were men. The baseline left ventricular ejection fraction was 40 (SD, 15%) and the mean Rassi score was 10 (SD, 4). No deaths occurred during DTT and no ICD failures were documented. There was a relationship between higher baseline Rassi scores and higher DTT scores (ANOVA = 0.007). The mean time to first shock was 474 (SD, 628) days, although shock was only necessary for 28 (35%) patients with ventricular tachycardia, since most cases resolved spontaneously or through antitachycardia pacing. After a mean clinical follow-up of 1728 (SD, 1189) days, 43 deaths occurred, mainly related to progressive heart failure and sepsis. Conclusions A routine DTT may not be necessary for CCC patients who receive an ICD for secondary prevention. High DTT values seem to be unusual and may be related to high Rassi scores.

https://doi.org/10.36660/abc.20210770

Tratamiento de caries relacionada a radiación: una revisión de literatura
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Mancia, Brenda Lisseth Pineda

; Rezende, Liliana Vicente Melo de Lucas

; Tabata, Lucas Fernando

; Garcia, Fernanda Cristina Pimentel

; Ribeiro, Ana Paula Dias

Odontoestomatología

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jun 2022, Volume 24 N. 39 elocation e310

Abstract: Es En Pt | Text: Es En Pt | PDF: Es | PDF: En | PDF: Pt

Resumen Caries relacionada a radiación es una complicación tardía frecuente de la radioterapia de cáncer de cabeza y cuello, ocasionada por efectos directos e indirectos de la radioterapia. El objetivo del presente trabajo es realizar una revisión y analizar literatura sobre el manejo de caries relacionada a radiación, materiales usados, fallas en el tratamiento y protocolo con mejores resultados; tres revisores independientes realizaron una búsqueda en diferentes bases de datos: PubMed, Lilacs y Web Of Science, determinando criterios de inclusión y exclusión para la selección. Estudios clínicos y revisiones indicaron que los materiales más usados son cemento ionómero de vidrio convencional, cemento ionómero de vidrio modificado con resina y resina compuesta con aplicaciones de flúor. Son necesarios más estudios para definir el mejor tratamiento que incluya técnica de preparación de la cavidad y material restaurador con mejores resultados. Se recomienda realizar estudios comparando diferentes sistemas adhesivos, concentraciones de flúor y restauraciones en dentina radicular.

Abstract Radiation-related caries are a frequent late complication caused by the direct and indirect effects of head and neck cancer radiotherapy. This study aimed to review and analyze the literature on managing radiation-related caries, restorative materials, treatment failures, and treatment protocols. A search was conducted in Pubmed, Lilacs, and Web of Science by three independent reviewers, and inclusion and exclusion criteria were used for paper selection. According to clinical studies and literature reviews, the most used materials are conventional glass-ionomer cement, resin-modified glass-ionomer cement, and composite resin with fluoride applications. More studies are needed to determine the best treatment, including cavity preparation technique and restorative material with better results. We suggest conducting studies comparing various adhesive systems, fluoride concentrations, and root dentin restorations.

Resumo Cárie relacionada à radiação é uma complicação tardia frequente da radioterapia de câncer de cabeça e pescoço, ocasionada por efeitos diretos e indiretos da radioterapia. O objetivo do presente trabalho é realizar uma revisão e analisar literatura sobre o tratamento de cárie relacionada à radiação, materiais usados, falhas no tratamento e manejo com melhores resultados; foi realizada uma busca em diferentes bases de dados: PubMed, Lilacs e Web Of Science, por três revisores independentes, usando critérios de inclusão e exclusão. Estudos clínicos e revisões de literatura indicam que os materiais mais usados são cimento de ionômero de vidro convencional, cimento de ionômero de vidro modificado com resina e resina composta com aplicações de flúor. Mais estudos são necessários para definir o melhor tratamento que inclua a técnica de preparo cavitário e material restaurador com melhores resultados. Recomenda-se a realização de estudos comparando diferentes sistemas adesivos, concentrações de flúor e restaurações em dentina radicular.

https://doi.org/10.22592/ode2022n39e310

The ovarian and uterine responses of Baixadeiro mares to prostaglandin synchronization during the dry and rainy seasons
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Rosa, Luciana Cordeiro

; Dias, Eliane Cristina Silva

; Melo, Renatta Silva

; Rosário, Carla Janaína Rebouças Marques do

; Pereira, Felipe Lucas Correa

; Chung, Luiz Bruno Oliveira

; Anunciação, Adriana Raquel de Almeida da

; Moraes Junior, Felipe de Jesus

; Souza, Fernando Andrade

; Chaves, Ricardo de Macêdo

Animal Reproduction

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2022, Volume 19 N. 1 elocation e20200050

Abstract: En | Text: En | PDF: En

Abstract This study aimed to evaluate the effect of synchronization with prostaglandin F2α in Baixadeiro mares during the rainy and dry seasons. Fourteen mares were synchronized by administering two doses of 1 mL prostaglandin PGF 2α and monitored by rectal palpation and ultrasound for the assessment of follicular development and uterine echotexture. Of this total, nine mares allowed the collection of blood, in which the blood was collected by venipuncture of the jugular vein to determine progesterone (P4) by ELISA. Mares showed no differences (P > 0.05) in weight, body score condition (BSC), tone, uterine edema, frequency of ovulation, synchronization interval, estrus, and the total number of follicles between periods. However, there was a difference in large increased follicle diameter (P < 0.05) during the dry season. The average concentrations of P4 in mares differed (P < 0.05) between the pre- and post-ovulatory phases for both seasons and after ovulation, with higher concentrations in the rainy season. Furthermore, statistical differences in daily light (P < 0.05) were observed between the dry and rainy periods. Thus, we conclude that mares from the genetic grouping Baixadeiro showed no reproductive seasonality, though there was a difference in luminosity between the rainy and dry seasons. The treatment with two doses of PGF 2α was effective in synchronizing the mares, promoting the return of estrus in the dry and rainy periods. The mares remaining cyclically active throughout the year provided there were appropriate forage availability and quality levels to allow for normal values of body weight and condition.

https://doi.org/10.1590/1984-3143-ar2020-0050

Carbon and Nitrogen Stocks and Microbiological Activity Under Forest-Pasture System and Traditional Pasture in Pernambuco
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Pessôa, Gabriel Carlos Moura

; Piscoya, Victor Casimiro

; Rolim Neto, Fernando Cartaxo

; Araújo Filho, Renisson Neponuceno de

; Melo, Robson Carlos Pereira de

; Pessôa, Uriel Calisto Moura

; Silva, Lucas José de Souza

; Cunha Filho, Moacyr

; Almeida, Rafael Costa Schaidhauer de

; Piscoya, Thaisa Oliveira Folha

; Moraes, Alex Souza

; Gomes Filho, Raimundo Rodrigues

; Medeiros, Raimundo Mainar de

; Saboya, Luciano Marcelo Fallé

; Pedrotti, Alceu

; Holanda, Francisco Sandro Rodrigues

; Fernandes, Milton Marques

; Santos, Luiz Diego Vidal

Floresta e Ambiente

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2022, Volume 29 N. 2 elocation e20210068

Abstract: En | Text: En | PDF: En

Abstract An adequate amount of soil organic matter is considered essential for long-term sustainable agriculture, ensuring good productivity. Therefore, the present study quantified carbon and nitrogen stocks and microbiological activity in soil of three different areas: Forest-pasture System, Pasture System and preserved Caatinga - used as a reference of the experiment - located in a semi-arid region, in Watershed of Pajeú River, state of Pernambuco, Brazil. Eight trenches were opened in each system to collect soil samples at depths of 0 - 10, 20 - 30 and 50 - 60 cm, for chemical and microbiological analysis. In general, attributes of soil showed better results of land use in the following order: preserved Caatinga - Forest-pasture System - Pasture System.

https://doi.org/10.1590/2179-8087-floram-2021-0068

Impact of bariatric surgery in elderly patients with obesity
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PEREIRA, ADRIANO F.

; SANTA-CRUZ, FERNANDO

; COUTINHO, LUCAS R.

; VIEIRA-DE-MELO, MARIA CLARA P. T.

; HINRICHSEN, EDUARDA A.

; SIQUEIRA, LUCIANA T.

; FIGUEIREDO, JOSÉ-LUIZ

; FERRAZ, ÁLVARO A. B.

Revista do Colégio Brasileiro de Cirurgiões

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2022, Volume 49 elocation e20223299

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Introdução: avaliar o impacto da cirurgia bariátrica na população idosa no longo prazo. Métodos: estudo retrospectivo que incluiu todos os pacientes com mais de 60 anos submetidos ao Bypass gástrico em Y de Roux (BGYR) em nosso centro e que mantiveram seguimento superior a 1 ano. Foram estudadas variáveis clínicas e laboratoriais para avaliação da remissão da obesidade e suas comorbidades, além de variáveis diretamente relacionados ao procedimento cirúrgico em si, incluindo complicações precoces e tardias. Resultados: foram estudados 56 pacientes, a maioria do sexo feminino (76,8%), com idade média de 64,02 ± 3,34. Foi observada uma taxa de complicações de 37,5%, com 10,7% requerendo internamento hospitalar e cirurgia de urgência. A média geral da perda do excesso de peso (%PEP) foi de 74,22% ± 26,76. As taxas de remissão de hipertensão e diabetes mellitus foram de 26,08% e 54,54%, respectivamente. Houve variação significativa no IMC (12,25 ± 5,42, p<0,001), colesterol total (31,37 ± 38,89 p<0,001), colesterol LDL (23,45 ± 34,9, p=0,002), colesterol HDL (5,14 ± 11,13, p=0,024), triglicerídeos (48,85 ± 56,15 p<0,001), HbA1C (1,81 ± 1,97, p<0,001) e PCR (1,43 ± 1,96, p<0,001). Conclusão: a cirurgia bariátrica se mostrou eficaz na perda de peso e na remissão de comorbidades na população de idosos com obesidade no longo prazo..

ABSTRACT Introduction: to evaluate the long-term impact of bariatric surgery in the elderly population. Methods: a retrospective study including all patients older than 60 years who underwent Roux-en-Y gastric bypass (RYGB) at our center and maintained a follow-up longer than 1 year. Clinical and laboratory variables were studied to assess remission of obesity and its comorbidities, as well as variables directly related to the surgical procedure itself, including early and late complications. Results: fifty-six patients were studied, mostly female (76,8%), with a mean age of 64.02 ± 3.34. A rate of complications of 37,5% was observed, with 10,7% requiring hospital admission and emergency surgery. The mean excess weight loss (%EWL) was 74.22% ± 26.76. The remission rates of hypertension and diabetes mellitus were 26.08% and 54.54%, respectively. There was significant difference in BMI reduction (12.25 ± 5.42, p<0.001), total cholesterol (31.37 ± 38.89 p<0,001), LDL cholesterol (23.45 ± 34.9, p=0.002), HDL cholesterol (5.14 ± 11.13, p=0,024), triglycerides (48.85 ± 56.15 p<0.001), HbA1C (1,81 ± 1,97, p<0,001) e PCR (1.43 ± 1.96, p<0.001). Conclusion: bariatric surgery was effective in weight loss and remission of comorbidities in the elderly obese population within the long term.

https://doi.org/10.1590/0100-6991e-20223299-en

Chemical constituents, antioxidant potential, antibacterial study and photoprotective activity of Brazilian corn silk extract
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AZEVEDO, Amanda Scofield de

; SEIBERT, Janaína Brandão

; AMPARO, Tatiane Roquete

; ANTUNES, Amanda dos Santos

; SOUSA, Lucas Resende Dutra

; SOUZA, Gustavo Henrique Bianco de

; TEIXEIRA, Luiz Fernando Medeiros

; VIEIRA, Paula Melo de Abreu

; SANTOS, Viviane Martins Rebello dos

; NASCIMENTO, Adriana Mendes do

; NASCIMENTO, Andréa Mendes do

Food Science and Technology

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2022, Volume 42 elocation e98421

Abstract: En | Text: En | PDF: En

Abstract The aim of this work was to determine the total phenolic content and evaluate the antioxidant, antibacterial, photoprotective and cytotoxic properties of corn silk ethanol extract prepared from corn silk that was air-dried at room temperature. Corn silk ethanol extract has a high content of phenolic compounds. The concentrations of ethanol extract required to produce 50% of maximal effect (EC50) in DPPH and ABTS radical scavenging assays were 489.0 and 166.1 µg/mL respectively, indicating low activity when compared to the positive control. The ethanolic extract of corn silk showed antibacterial activity, mainly on Gram-positive bacteria. The in vitro sun protection factor (SPF) of the ethanolic extract of corn silk incorporated into sunscreen UVA-UVB 5% gel with Pemulen TR-1® was evaluated for the first time. A relative increase in SPF efficacy was observed for the extract when the sunscreen was incorporated. The ethanolic extract of corn silk and the gel were considered non-cytotoxic. The corn silk ethanolic extract was characterized using ultra performance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry (UPLC-QTOF-MS/MS). Eleven compounds including flavonoids, coumaric acid derivatives, terpenoid, hydroxycinnamic acid derivative and quinic acid derivative were suggested based on their accurate mass and MS/MS spectra.

https://doi.org/10.1590/fst.98421

Teste de Limiar de Desfibrilação e Seguimento a Longo Prazo de Pacientes com Cardiopatia Crônica da Doença de Chagas
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Campos, Marco Paulo Cunha

; Bernardes, Luiz Fernando Gouveia

; Melo, João Paulo Chaves de

; Santos, Lucas Corsino dos

; Teixeira, Cristiano Honório Ribeiro

; Pavão, Maria Licia Ribeiro Cury

; Arfelli, Elerson

; Scorzoni Filho, Adilson

; Rassi Jr, Anis

; Marin-Neto, José A.

; Schmidt, André

Arquivos Brasileiros de Cardiologia

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2022, N. ahead

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

https://doi.org/10.36660/abc.20210770

Update of the epidemiological distribution of COVID-19 variants: a review article
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Azevedo, Thomás Cavalcanti Pires de

; Melo, Vanessa Santos Cavalcante

; Silva, Renata Maciel da

; Barbosa, Beatriz Guerra de Holanda

; Christofoletti, Lucas Zloccowick de Melo

; Nascimento, Giovanna Maria Correia Silva do

; Oliveira, Guilherme Santos Lins de

; Barbosa, Fabiano Timbó

; Sousa-Rodrigues, Célio Fernando de

; Ramos, Fernando Wagner da Silva

Revista da Associação Médica Brasileira

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sep 2021, Volume 67 N. 9 Pages 1368 - 1371

Abstract: En | Text: En | PDF: En

https://doi.org/10.1590/1806-9282.20210625

10.

MicroRNA-27b Expression in Rats Submitted to Physical Exercise and Experimental Cerebral Ischemia
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De-Russi, Brenno Marco

; Porsani, Lucas Barbosa

; Cirino, Mucio Luiz de Assis

; Silva, Jairo Pinheiro da

; Turra, Letícia Passi

; Novais, Paulo Cezar

; Lizarte-Neto, Fermino Sanches

; Fazan, Valéria de Paula Sassoli

; Thomazini, José Antônio

; Colli, Benedicto Oscar

; Tirapelli, Daniela Pretti da Cunha

; Tirapelli, Luis Fernando

; Carvalho, Camila Albuquerque Melo de

International Journal of Morphology

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jun 2021, Volume 39 N. 3 Pages 754 - 758

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

SUMMARY: Cerebral ischemia has not only a high mortality rate, which is the second leading cause of death worldwide, but is also responsible for severe disabilities in working age individuals, generating enormous public expending for treatment and rehabilitation of the affected individuals. The role of microRNAs in the pathophysiology of cerebral ischemia has been highlighted in current investigations. In addition, recent studies have also highlighted physical exercise as a possible protective factor both in the prevention and in the effects of cerebral ischemia, placing it as an important study resource. Thus, we investigated the role of physical exercise in experimental cerebral ischemia associated with the expression of microRNA-27b. 16 animals were used, divided into four experimental groups: Control, Physical Exercise, Cerebral Ischemia and Cerebral Ischemia associated with Physical Exercise. The real-time PCR methodology was used to analyze the expression of microRNA-27b. Although there were no statistically significant differences in the expression of microRNA-27b between the groups studied, the increased expression of microRNA-27b in the Physical Exercise group indicates its neuroprotective role in the pathophysiology of cerebral ischemia.

RESUMEN: La isquemia cerebral no solo tiene una alta tasa de mortalidad y es la segunda causa principal de muerte en todo el mundo, sino también es la causa de enfermedades invalidantes en personas en edad laboral, lo que genera un gasto público enorme para el tratamiento y la rehabilitación de las personas afectadas. El papel de los microARN en la fisiopatología de la isquemia cerebral se ha destacado en las investigaciones actuales. Además, estudios recientes también han destacado el ejercicio físico como un posible factor protector tanto en la prevención como en los efectos de la isquemia cerebral, situándolo como un importante recurso de estudio. Por lo tanto, investigamos el papel del ejercicio físico en la isquemia cerebral experimental asociada con la expresión del microARN-27b. Se utilizaron 16 animales, divididos en cuatro grupos experimentales: Control, Ejercicio Físico, Isquemia Cerebral e Isquemia Cerebral asociada al Ejercicio Físico. Se utili- zó la metodología de PCR en tiempo real para analizar la expresión de microARN-27b. Aunque no se observaron diferencias estadísticamente significativas en la expresión de microARN-27b entre los grupos estudiados, la mayor expresión de microARN-27b en el grupo de Ejercicio Físico indica su papel neuroprotector en la fisiopatología de la isquemia cerebral.

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11.

Cannabinoids in Neurology - Position paper from Scientific Departments from Brazilian Academy of Neurology
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BRUCKI, Sonia Maria Dozzi

; ADONI, Tarso

; ALMEIDA, Carlos Mauricio Oliveira

; ANDRADE, Daniel Ciampi de

; ANGHINAH, Renato

; BARBOSA, Luciana Mendonça

; BAZAN, Rodrigo

; CARVALHO, Alzira Alves de Siqueira

; CARVALHO, William

; CHRISTO, Paulo Pereira

; COLETTA, Marcus Della

; CONFORTO, Adriana Bastos

; CORREA-NETO, Ylmar

; ENGELHARDT, Eliasz

; FRANÇA JUNIOR, Marcondes Cavalcante

; FRANCO, Clelia

; VON GLEHN, Felipe

; GOMES, Helio Rodrigues

; HOULY, Caroline Gomes de Barros

; KAUP, Alexandre Ottoni

; KOWACS, Fernando

; KANASHIRO, Aline

; LOPES, Victor Gonçalves

; MAIA, Débora

; MANREZA, Maria

; MARTINEZ, Alberto Rolim Muro

; MARTINEZ, Sandra Cristina Gonçalves

; NADER, Saulo Nardy

; NEVES, Luciana de Oliveira

; OKAMOTO, Ivan Hideyo

; OLIVEIRA, Rogério Adas Ayres de

; PEIXOTO, Fabiano de Melo

; PEREIRA, Cristiana Borges

; SABA, Roberta Arb

; SAMPAIO, Leticia Pereira de Brito

; SCHILLING, Lucas Porcello

; SILVA, Marcus Tulius Teixeira

; SILVA, Emanuelle Roberta

; SMID, Jerusa

; SOARES, Cristiane Nascimento

; SOBREIRA-NETO, Manoel

; SOUSA, Nise Alessandra de Carvalho

; SOUZA, Leonardo Cruz de

; TEIVE, Hélio Afonso Ghizoni

; TERRA, Vera Cristina

; VALE, Matheus

; VIEIRA, Vitor Mendes Grise

; ZANOTELI, Edmar

; PRADO, Gilmar

Arquivos de Neuro-Psiquiatria

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apr 2021, Volume 79 N. 4 Pages 354 - 369

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Os canabinoides compreendem os endocanabinoides, fitocanabinoides e os canabinoides sintéticos e desempenham ações no sistema nervoso central e periférico. Uma quantidade enorme de publicações tem sido lançada nos últimos anos, embora a cannabis seja conhecida por milênios. Os Departamentos Científicos da Academia Brasileira de Neurologia descreveram as evidências do uso médico em suas áreas. A literatura está em constantes mudanças e possíveis novas evidências podem surgir nos próximos dias ou meses. A prescrição dessas substâncias deve ser discutida com os pacientes e suas famílias, com conhecimento sobre eventos adversos e sua eficácia.

ABSTRACT Cannabinoids comprehend endocannabinoids, phytocannabinoids, and synthetic cannabinoids, with actions both in the central and peripherical nervous systems. A considerable amount of publications have been made in recent years, although cannabis has been known for over a thousand years. Scientific Departments from the Brazilian Academy of Neurology described evidence for medical use in their areas. Literature is constantly changing, and possible new evidence can emerge in the next days or months. Prescription of these substances must be discussed with patients and their families, with knowledge about adverse events and their efficacy.

https://doi.org/10.1590/0004-282x-anp-2020-0432 1049 downloads

12.

Pathological findings and morphologic correlation of the lungs of autopsied patients with SARS-CoV-2 infection in the Brazilian Amazon using transmission electron microscopy
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Santana, Monique Freire

; Pinto, Rebecca Augusta de Araújo

; Marcon, Bruna Hilzendeger

; Medeiros, Lia Carolina Almeida Soares de

; Morais, Thiago Barros do Nascimento de

; Dias, Lucas Castanhola

; Souza, Lorenna Pereira de

; Melo, Gisely Cardoso de

; Monteiro, Wuelton Marcelo

; Lacerda, Marcus Vinicius Guimarães

; Val, Fernando Almeida

; Lalwani, Pritesh Jaychand

; Ferreira, Luiz Carlos de Lima

Revista da Sociedade Brasileira de Medicina Tropical

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2021, Volume 54 elocation e0850-2020

Abstract: En | Text: En | PDF: En

Abstract INTRODUCTION: Electron microscopy (EM) is a rapid and effective tool that can be used to create images of a whole spectrum of virus-host interactions and, as such, has long been used in the discovery and description of viral mechanisms. METHODS: Electron microscopy was used to evaluate the pulmonary pathologies of postmortem lung sections from three patients who died from infection with SARS-associated coronavirus 2 (SARS-CoV-2), a new member of the Coronaviridae family. RESULTS: Diffuse alveolar damage (DAD) was predominant in all three patients. The early exudative stage was characterized principally by edema and extravasation of red blood cells into the alveolar space with injury to the alveolar epithelial cells; this was followed by detachment, apoptosis, and necrosis of type I and II pneumocytes. The capillaries exhibited congestion, exposure of the basement membrane from denuded endothelial cells, platelet adhesion, fibrin thrombi, and rupture of the capillary walls. The proliferative stage was characterized by pronounced proliferation of type II alveolar pneumocytes and multinucleated giant cells. The cytopathic effect of SARS-CoV-2 was observed both in degenerated type II pneumocytes and freely circulating in the alveoli, with components from virions, macrophages, lymphocytes, and cellular debris. CONCLUSIONS: Viral particles consistent with the characteristics of SARS-CoV-2 were observed mainly in degenerated pneumocytes, in the endothelium, or freely circulating in the alveoli. In the final stage of illness, the alveolar spaces were replaced by fibrosis.

https://doi.org/10.1590/0037-8682-0850-2020 1013 downloads

13.

Formação ampliada durante residência multiprofissional em saúde: relato de experiência de um cirurgião-dentista com o povo Xukuru do Ororubá (Pernambuco/Brasil)
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Santos, Lucas Fernando Rodrigues dos

; Maurício, Herika de Arruda

; Lins, Fabíola de Melo

; Silva, Isllany Karine Santos da

; Moreira, Rafael da Silveira

Interface - Comunicação, Saúde, Educação

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2021, Volume 25 elocation e200549

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

A partir das recomendações sobre experiências que aproximam a formação em saúde da realidade de populações em situação de vulnerabilidade, apresenta-se um relato de experiência, na perspectiva de um trabalhador residente em saúde, sobre a vivência de estágio no Território Indígena Xukuru do Ororubá (Pernambuco/Brasil). Emergiram reflexões sobre as condições de vida e saúde do povo indígena, o processo pedagógico de estágio e repercussões na formação e no fazer profissional, além das fragilidades relacionadas à cobertura e longitudinalidade do cuidado em saúde bucal. Por meio de intervenções com a perspectiva de autonomia dos sujeitos, foi possível aprimorar o olhar sociopolítico à questão indígena. Aponta-se a potencialidade da proposta, que estimula o confronto entre saberes profissionais instituídos e a realidade objetiva das comunidades, buscando superar o modelo colonial de cuidado, ampliando a perspectiva de atuação do profissional em formação para o Sistema Único de Saúde (SUS).

This is an experience report, based on the recommendations that call to close the gap between health education and the reality of populations in vulnerable situations, from the perspective of a residence worker, about the internship experience in the Xukuru do Ororubá Indigenous Territory (Pernambuco/Brazil). The observations emerged regarding the living and health conditions of the indigenous people, the internship pedagogical process and its repercussions on professional training and practice, as well as the weaknesses related to the coverage and longitudinality of oral health care. It was possible to improve the socio-political glance at the indigenous issue through interventions from the perspective of subject autonomy. The potentiality of the proposal is evident, stimulating the confrontation between established professional knowledge and the objective reality of the communities, seeking to overcome the colonial model of care, expanding the perspective of professional training for the Brazilian National Health System (SUS).

A partir de las recomendaciones sobre experiencias que aproximan la formación en salud de la realidad de poblaciones en situación de vulnerabilidad, se presenta un relato de experiencia, desde la perspectiva de un trabajador residente de salud, sobre la experiencia de pasantía en el Territorio Indígena Xukuru del Ororubá (Pernambuco/Brasil). Surgieron reflexiones sobre las condiciones de vida y salud del pueblo indígena, el proceso pedagógico de la pasantía y las repercusiones en la formación y el quehacer profesional, además de las fragilidades relacionadas con la cobertura y longitudinalidad del cuidado de salud bucal. Por medio de intervenciones con la perspectiva de autonomía de los sujetos, fue posible perfeccionar la mirada sociopolítica sobre la cuestión indígena. Se señala la potencialidad de la propuesta que incentiva el enfrentamiento entre saberes profesionales instituidos y la realidad objetiva de las comunidades, buscando la superación del modelo colonial de cuidado, ampliando la perspectiva de actuación del profesional en formación para el Sistema Brasileño de Salud (SUS).

https://doi.org/10.1590/interface.200549

14.

Formação ampliada durante residência multiprofissional em saúde: relato de experiência de um cirurgião-dentista com o povo Xukuru do Ororubá (Pernambuco/Brasil)
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Santos, Lucas Fernando Rodrigues dos

; Maurício, Herika de Arruda

; Lins, Fabíola de Melo

; Silva, Isllany Karine Santos da

; Moreira, Rafael da Silveira

Interface - Comunicação, Saúde, Educação

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2021, Volume 25 elocation e200549

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

https://doi.org/10.1590/interface.200549 240 downloads

15.

Atualização das Diretrizes Brasileiras de Valvopatias – 2020
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Tarasoutchi, Flavio

; Montera, Marcelo Westerlund

; Ramos, Auristela Isabel de Oliveira

; Sampaio, Roney Orismar

; Rosa, Vitor Emer Egypto

; Accorsi, Tarso Augusto Duenhas

; Santis, Antonio de

; Fernandes, João Ricardo Cordeiro

; Pires, Lucas José Tachotti

; Spina, Guilherme S.

; Vieira, Marcelo Luiz Campos

; Lavitola, Paulo de Lara

; Ávila, Walkiria Samuel

; Paixão, Milena Ribeiro

; Bignoto, Tiago

; Togna, Dorival Júlio Della

; Mesquita, Evandro Tinoco

; Esteves, William Antônio de Magalhães

; Atik, Fernando

; Colafranceschi, Alexandre Siciliano

; Moises, Valdir Ambrósio

; Kiyose, Alberto Takeshi

; Pomerantzeff, Pablo M. A.

; Lemos, Pedro A.

; Brito Junior, Fabio Sandoli de

; Weksler, Clara

; Brandão, Carlos Manuel de Almeida

; Poffo, Robinson

; Simões, Ricardo

; Rassi, Salvador

; Leães, Paulo Ernesto

; Mourilhe-Rocha, Ricardo

; Pena, José Luiz Barros

; Jatene, Fabio Biscegli

; Barbosa, Márcia de Melo

; Abizaid, Alexandre

; Ribeiro, Henrique Barbosa

; Bacal, Fernando

; Rochitte, Carlos Eduardo

; Fonseca, José Honório de Almeida Palma da

; Ghorayeb, Samira Kaissar Nasr

; Lopes, Marcelo Antonio Cartaxo Queiroga

; Spina, Salvador Vicente

; Pignatelli, Ricardo H.

; Saraiva, José Francisco Kerr

Arquivos Brasileiros de Cardiologia

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oct 2020, Volume 115 N. 4 Pages 720 - 775

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

https://doi.org/10.36660/abc.20201047 17824 downloads

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