Abstract: Bullous pemphigoid, mucous membrane pemphigoid and epidermolysis bullosa acquisita are subepidermal autoimmune blistering diseases whose antigenic target is located at the basement membrane zone. Mucous membrane pemphigoid and epidermolysis bullosa acquisita can evolve with cicatricial mucosal involvement, leading to respiratory, ocular and/or digestive sequelae with important morbidity. For each of these dermatoses, a literature review covering all therapeutic options was performed. A flowchart, based on the experience and joint discussion among the authors of this consensus, was constructed to provide treatment orientation for these diseases in Brazil. In summary, in the localized, low-risk or non-severe forms, drugs that have immunomodulatory action such as dapsone, doxycycline among others may be a therapeutic option. Topical treatment with corticosteroids or immunomodulators may also be used. Systemic corticosteroid therapy continues to be the treatment of choice for severe forms, especially those involving ocular, laryngeal-pharyngeal and/or esophageal mucosal involvement, as may occur in mucous membrane pemphigoid and epidermolysis bullosa acquisita. Several immunosuppressants are used as adjuvant alternatives. In severe and recalcitrant cases, intravenous immunoglobulin is an alternative that, while expensive, may be used. Immunobiological drugs such as rituximab are promising drugs in this area. Omalizumab has been used in bullous pemphigoid.
Human papillomavirus infection is common and causes different manifestations. This infection is a public health concern because it has been associated with genital tract malignant diseases among men and women. Currently two vaccines are available to prevent the human papillomavirus infection and its associated diseases.
A infecção pelo papilomavírus humano é comum e produz manifestações diversas. Essa infecção adquire importância para saúde pública, pois tem sido associada a malignidades do trato genital em homens e mulheres. Atualmente, temos disponíveis duas vacinas para prevenção da infecção pelo papilomavírus humano e, consequentemente, de doenças a ele associadas.
BACKGROUND: Bacterial pneumonia is one of the main causes of morbidity and mortality in patients infected by the human immunodeficiency virus (HIV). The main objective of this study was to evaluate the effect of macrolide therapy in combination with a beta-lactam based empiric regimen for inpatients with community-acquired pneumonia and HIV. METHODS: This is a retrospective cohort study of hospitalized patients. Adult patients who had received treatment with ceftriaxone or ceftriaxone plus clarithromycin were included. RESULTS: 76 patients met the inclusion criteria. Among baseline characteristics analyzed, only respiratory rate showed significant difference: patients who had received clarithromycin were more likely to have a respiratory rate > 30/min than patients who received only ceftriaxone (64% versus 36%, p = 0.03). ICU admission was the only outcome that showed a significant difference, more frequent in the ceftriaxone plus clarithromycin group (45% versus 20%, p = 0.03). CONCLUSIONS: This study does not support the addition of a macrolide to a beta-lactam based regimen in HIV-infected patients. This is probably related to the patients' immunodeficiency status, which impairs the immunomodulatory properties of the macrolides.
The University Hospital of the Federal University of Minas Gerais is used as a training field for nursing undergraduate students. Therefore, the Hospital and the Nursing School, with a view to integrating teaching and service, created a Nurse Training Commission in order to coordinate curricular and extracurricular training in this area, systematically organizing the technical visits and the voluntary work and to implement a Continuing Education Program. The purpose of this article is to report the experience of implementing this Commission, showing its actions and the results achieved. The work of the Commission is contributing to the students' development and professional improvement as well as to the members of the nursing team.
El Hospital de Clínicas de la Universidad Federal de Minas Gerais se emplea como campo de entrenamiento para cursos de graduación y nivel intermedio del curso de Enfermería. En este contexto el Hospital y la Escuela de Enfermería de la Universidad Federal de Minas Gerais designaron una Comisión de Capacitación de Enfermeros con miras a integrar enseñanza - trabajo. Las tareas asignadas a dicha comisión fueron: coordinar los entrenamientos curriculares y extracurriculares en enfermería, sistematizar las visitas técnicas y el voluntariado e implantar el Programa de Educación Continuada. El objetivo de este artículo es relatar la experiencia de implantación de tal comisión, evidenciando su trayectoria y los resultados alcanzados. El trabajo de la comisión ha contribuido al desarrollo y crecimiento profesional de los alumnos y de los trabajadores en enfermería.
O Hospital das Clínicas da Universidade Federal de Minas Gerais-HC-UFMG é utilizado como campo de estágio para cursos de graduação e de nível médio da enfermagem. Neste contexto, o Hospital e a Escola de Enfermagem-UFMG, visando à integração ensino-serviço, instituíram a Comissão de Estágios em Enfermagem para coordenar os estágios curriculares e extracurriculares nesta área; sistematizar as visitas técnicas e o trabalho voluntário e implantar o Programa de Educação Continuada. O objetivo deste artigo é relatar a experiência de implantação desta Comissão, evidenciando a sua trajetória e os resultados alcançados. O trabalho da Comissão tem contribuído para o desenvolvimento e crescimento profissional dos estagiários e dos trabalhadores da enfermagem.