Bullous pemphigoid (BP) is an autoimmune, acquired, cutaneous disease caused by the production of autoantibodies against hemidesmosomes' components in the basement membrane. The estimated incidence in Europe ranges from 7 to 43 cases per million inhabitants per year. Several studies have reported an association between BP and neurological disorders (ND). Our cohort of Bullous pemphigoid and ND is the first in Brazil and showed a significantly high prevalence of neurological and/or psychiatric diseases, especially cerebrovascular accident (CVA) and dementia, in agreement with the prevalence reported in several studies published in the medical literature in recent years.

The surgical approach to lentigo maligna is a challenge to dermatologists, given the difficulty of clinical delimitation of borders. We report here a case of a 69-year-old female patient presenting with brownish macules on her face, since 10 years ago, with histopathological diagnosis of lentigo maligna. The surgical management employed was excision of visible borders with the contoured technique and immediate submission of these borders for histopathological analysis before complete excision of the tumor. This technique is a variant of staged excision, with lower rates of recurrence and acceptable aesthetic results.

Pigmented Bowen's disease is rare, though more prevalent in men. It presents as a well-delineated plaque in areas unexposed to sun. There are reports of association with seborrheic keratosis, solar lentigo or exuberant pigmentation of genital and intertriginous regions. A specific dermoscopy finding is the presence of brown or gray dots in regular arrangement and coiled or dotted vessels. Thus, we aim to raise awareness of the diagnosis of pigmented Bowen's disease in pigmented lesions.

Introducción: El hemangioendotelioma hepático infantil es el tumor primario del hígado más común en la infancia. Se presenta en pacientes menores de 6 meses, puede ser diagnosticado in útero, donde las grandes comunicaciones arteriovenosas producen hidrops fetal no inmune. Objetivo: Se describe un caso de un feto muerto con un hemangioendotelioma hepático infantil y se realiza una discusión sobre este tema. Caso clínico: Producto de un embarazo de 33 semanas de gestación de una mujer de 23 años, la ecografía obstétrica evidencio hidrops fetal secundario a presencia de tumor hepático, el paciente fallece minutos después de su nacimiento. En la necropsia se evidencia feto de sexo masculino de 3250 gr de peso, con tumor hepático de características sólidas, cuyo examen histopatológico corresponde con un hemangioendotelioma hepático infantil. Conclusiones: Se presenta el estudio anatomopatológico de una autopsia perinatal realizada a un feto con tumor congénito, un hemangioendotelioma hepático infantil que produjo hidrops fetal no inmune. Salud UIS 2010; 42: 123-126

Introduction: Infantile hepatic hemangioendothelioma (HHI) is the primary liver tumor more common in childhood. Usually occurs before the 6 months of age. These tumors can be diagnosed in utero, where the large arteriovenous shunting cause non-inmune hydrops fetalis. Objetive: Describe a case of a dead fetus with a hepatic hemangioendothelioma and a discussion on this topic is done. Clinical case: Product of pregnancy of 33 weeks of gestation in a 23 years old woman, obstetrical ultrasound evidenced fetal hydrops secondary to the presence of liver tumor, the patient died minutes after birth. The necropsy showed a male fetus of 3250gr in weight, with a liver tumor with solid features, which histopathological examination corresponds to a HHI. Conclusions: We report the pathological study of a perinatal autopsy done to a fetus with a congenital tumor, an HHI that cause non-inmune hydrops fetalis. Salud UIS 2010; 42: 123-126.