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Abstract Resin composites containing surface pre-reacted glass (S-PRG) have been introduced to reduce demineralization and improve remineralization of the tooth structure. However, water diffusion within the material is necessary for its action, which can impair its overall physicomechanical properties over time, including color stability. This study aimed to evaluate the color stability and related degree of conversion (DC) of four resin composites. Discs (6 x 4 mm, n = 5/group) of microhybrid (MH), nanofilled (NF), nanohybrid (NH), and S-PRG-based nanohybrid (S-PRG-NH) composites with two opacities (A2/A2E and A2O/A2D) were prepared. Color (CIELab and CIEDE2000) was evaluated with a spectrophotometer after aging in grape juice (2 x 10 min/10mL/7days). The DC was analyzed by using Fourier transform infrared spectroscopy before and after light-curing. Data were statistically analyzed by using two-way analysis of variance and post-hoc least significant difference tests (p<0.05). In the color stability analysis, the interaction between filler type and opacity was significant (CIELab, p = 0.0015; CIEDE2000, p = 0.0026). NH presented the highest color stability, which did not differ from that of MH. The greatest color alteration was observed for S-PRG-NH. S-PRG fillers also influenced DC (p < 0.05). The nanohybrid resin composite presented favorable overall performance, which is likely related to its more stable organic content. Notwithstanding the benefits of using S-PRG-based nanohybrid resins, mostly in aesthetic procedures, professionals should consider the susceptibility of such resins to color alteration, probably due to the water-based bioactive mechanism of action.

https://doi.org/10.1590/1807-3107bor-2024.vol38.0003

As Disputas entre Ortodoxos e Heterodoxos: O que é (e o que não é) Economia Heterodoxos
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Marques, Francisco

Dados

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2024, Volume 67 N. 2 elocation e20210280

RESUMO Recorrendo ao conceito bourdieusiano de campo científico, este artigo se dedica a compreender como as fronteiras que delimitam o que é a Economia têm sido definidas. Para tanto, são identificadas e analisadas as relações estabelecidas entre ortodoxos e heterodoxos e entre ortodoxos, heterodoxos e os demais agentes do campo. A exemplo de outros estudos, os programas de pós-graduação da PUC-Rio e da FGV-Rio, de um lado, e da UFRJ e da Unicamp, de outro, foram tomados, respectivamente, como os representantes paradigmáticos da ortodoxia e da heterodoxia. O mapeamento das redes de interações mostra que, em que pese a importância da oposição entre o liberalismo neoclássico e seus críticos, o processo contínuo de disputas em torno dos limites definidores da Economia é complexo e multifacetado. Em vez de se encerrar exclusivamente no enfrentamento entre dominantes e não dominantes, o campo abriga ortodoxos e heterodoxos de variadas matizes, em diferentes situações. científico definidas tanto estudos pósgraduação pós graduação PUCRio PUC Rio FGVRio, FGVRio FGV Rio, FGV-Rio lado Unicamp outro tomados respectivamente heterodoxia críticos multifacetado matizes situações

RESUMEN Recurriendo al concepto bourdiano de campo científico, este artículo se dedica a comprender cómo las fronteras que delimitan lo que es la Economía han sido definidas. Para tal fin, son identificadas y analizadas las relaciones establecidas entre ortodoxos y heterodoxos y entre ortodoxos, heterodoxos y los demás agentes del campo. Así como lo han hecho otros estudios, los programas de posgrado de la PUC-Rio y de la FGV-Rio, por un lado, y de la UFRJ y de la Unicamp, por el otro, fueron tomados, respectivamente, como los representantes paradigmáticos de la ortodoxia y de la heterodoxia. El mapeo de las redes de interacciones muestra que, a pesar de la importancia de la oposición entre el liberalismo neoclásico y sus críticos, el proceso continuo de disputas en torno de los limites definidores de la Economía es complejo y multifacético. En vez de encerrarse exclusivamente en el enfrentamiento entre dominantes y no dominantes, el campo abriga ortodoxos y heterodoxos de variados matices y en diferentes situaciones. científico definidas fin estudios PUCRio PUC Rio FGVRio, FGVRio FGV Rio, FGV-Rio lado Unicamp otro tomados respectivamente heterodoxia críticos multifacético situaciones

ABSTRACT This article aims at understanding how the boundaries of economics have been set. Using the Bourdieusian concept of the scientific field, it identifies and analyzes the relationships established between orthodox and heterodox, as well as among orthodox, heterodox and other agents in the field. As in previous studies, the graduate programs of PUC-Rio and FGV-Rio, on the one hand, and UFRJ and Unicamp, on the other, were taken respectively as paradigmatic examples of orthodoxy and heterodoxy. The mapping of interaction networks shows that, despite the importance of the opposition between neoclassical liberalism and its critics, the continuous disputes around setting boundaries in economics is complex and multifaceted. Rather than being restricted to a confrontation between dominant and non-dominant agents, the field is home to orthodox and heterodox scholars of varying shades in various contexts. set studies PUCRio PUC Rio FGVRio, FGVRio FGV Rio, FGV-Rio hand Unicamp heterodoxy that critics multifaceted nondominant non contexts

RÉSUMÉ Recourant au concept bourdieusien de champ scientifique, cet article s’attache à comprendre comment ont été définies les frontières qui délimitent ce qu’est l’Économie. À cette fin, les relations établies entre orthodoxes et hétérodoxes et entre orthodoxes, hétérodoxes et d’autres agents de terrain sont identifiées et analysées. À l’instar d’autres études, les programmes d’études supérieures de la PUC-Rio et de la FGV-Rio, d’une part, et de l’UFRJ et de l’Unicamp, d’autre part, ont été pris, respectivement, comme les représentants paradigmatiques de l’orthodoxie et de l’hétérodoxie. La cartographie des réseaux d’interaction montre que, malgré l’importance de l’opposition entre le libéralisme néoclassique et ses détracteurs, le processus continu de disputes autour des limites de définition de l’économie est complexe et multiforme. Au lieu d’aboutir exclusivement à l’affrontement entre dominants et non dominants, le champ abrite des orthodoxes et des hétérodoxes de diverses nuances, dans des situations différentes. scientifique sattache s attache quest qu lÉconomie. lÉconomie l Économie. Économie l’Économie fin dautres d autres analysées linstar instar études détudes PUCRio PUC Rio FGVRio, FGVRio FGV Rio, FGV-Rio dune une part lUFRJ UFRJ lUnicamp, lUnicamp Unicamp, Unicamp l’Unicamp dautre autre pris respectivement lorthodoxie orthodoxie lhétérodoxie. lhétérodoxie hétérodoxie. hétérodoxie l’hétérodoxie dinteraction interaction que limportance importance lopposition opposition détracteurs léconomie économie multiforme daboutir aboutir laffrontement affrontement nuances différentes

https://doi.org/10.1590/dados.2024.67.2.318

Dysphagia Aortica: An Uncommon and Potentially Life-Threatening Condition
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Vara-Luiz, Francisco

; Fernandes, Eduardo

; Barbosa, Fábio Pé D’Arca

; Albuquerque, Ana

; Marques, Ana Valada

; Fonseca, Jorge

GE-Portuguese Journal of Gastroenterology

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dec 2023, Volume 30 N. 6 Pages 66 - 68

Abstract: En | Text: En | PDF: En

https://doi.org/10.1159/000528108

Equity program: strategies on clinical studies as an aggregating potential program
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Crusoe, Edvan de Queiroz

; Hallack Neto, Abrahão Elias

; Nantes, Deise Ferreira

; Ribeiro, Eduardo Flavio Oliveira

; Pinto, Fernando Monteiro Correia

; Bortolini, Jaisson Andre Pagnoncelli

; Maciel, James Farley Rafael

; Marques Junior, Jose Francisco Comenalli

; Corrêa, Lorena Costa

; Capra, Marcelo Eduardo Zanella

; Carvalho, Maria do Perpétuo Socorro Sampaio

; Melo, Nelcivone Soares de

; Quintas, Rafaela Vasques de Oliveira

; Carneiro, Thiago Xavier

; Laforga, Violete Petitto

; Cunha, Renato Luiz Guerino

Hematology, Transfusion and Cell Therapy

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dec 2023, Volume 45 N. 4 Pages 417 - 418

Abstract: En | Text: En | PDF: En

https://doi.org/10.1016/j.htct.2023.07.001

Alfabetizar no primeiro ano em tempos de pandemia da COVID-19
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Rengifo-Herrera, Francisco José

; Medeiros Marques, Yone Martins

Revista de psicología (Santiago)

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dec 2023, Volume 32 N. 2 Pages 14 - 30

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo: A leitura como competência cultural requer instrução e ensaio para conduzir para aprendizagens e estratégias cognitivas complexas. Este artigo descreve os processos de aprendizagem e as estratégias de alfabetização em aulas online de 1º ano do ensino fundamental em uma escola pública durante a pandemia de COVID-19. Foram observados uma professora e cinco alunos em duas sessões online. Foi realizada uma análise microgenética dos processos de ensino/aprendizagem. Apesar do lockdown nas escolas, os resultados mostram como o planejamento do ensaio e a repetição, foram importantes estratégias dos professores para alcançar a alfabetização online. A análise e o planejamento das tarefas por parte da professora especialista indicam que as estratégias de ensino online orientaram as crianças para competências de alfabetização eficientes.

Abstract: Reading as cultural competence requires instruction and rehearsal to leads for new learning and more complex cognitive strategies. This paper describes the children's learning processes and teacher's literacy strategies in online classes to 1st year of elementary class in a public school during the COVID-19 outbreak. One teacher and five students in two online class sessions were observed. Microgenetic analyzes of teaching/learning processes was used. Despite the school lockdown and online teaching, results show how planned rehearsal and repetition were important teacher's strategies to achieve literacy learning. Tasks analysis and planning by an expert teacher indicate that the online teaching strategies guided the children to efficient literacy competences.

https://doi.org/10.5354/0719-0581.2023.67555

Semi-hydroponic cultivation of fertigated curly lettuce with calcium nitrate-enriched saline solutions
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Pessoa, Victor G.

; Góis, Helena M. de M. N.

; Oliveira, Francisco de A. de

; Oliveira, Mychelle K. T. de

; Cordeiro, Carla J. X.

; Oliveira, Carlos E. A. de

; Costa, Mário J. V.

; Marques, Isabelly C. da S.

Revista Brasileira de Engenharia Agrícola e Ambiental

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sep 2023, Volume 27 N. 9 Pages 712 - 718

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

ABSTRACT Lettuce is a leafy vegetable sensitive to salinity, and under saline stress conditions it presents nutritional imbalance, mainly in calcium absorption. Thus, the objective was to evaluate the effect of enriching the nutrient solution with calcium nitrate in solutions prepared with saline water in the lettuce crop. A completely randomized design was used, with five treatments and four replicates. The treatments were represented by five nutrient solutions [S1 - standard nutrient solution (SNP); S2 - SNP + NaCl (3.5 dS m-1); S3 - S2 + Ca (NO3)2 (50% = 6.86 mmol L-1); S4 - S2 + Ca(NO3)2 (100% = 9.15 mmol L-1); S5 - S2 + Ca(NO3)2 (150% = 11.43 mmol L-1)] in lettuce from the curly group, cv. Elba. After preparing the nutrient solutions, the solutions had the following electrical conductivities: 1.8 (S1); 4.8 (S2); 5.4 (S3); 6.0 (S4); 6.6 (S5) dS m-1. Variables of growth, nutrition and postharvest quality of lettuce were evaluated. With the exception of stem diameter, number of total leaves, plant pH and vitamin C content, the other variables were affected by the extra addition of Ca(NO3)2 in the nutrient solutions. The lettuce cv Elba grown in coconut fiber is tolerant to the salinity of 4.8 dS m-1 (S2). In conditions where the use of saline water with 3.5 dS m-1 for the preparation of the nutrient solution is unavoidable, the use of extra doses of Ca(NO3)2 in the lettuce crop is not recommended.

RESUMO A alface é uma hortaliça folhosa sensível à salinidade, e em condições de estresse salino apresenta crescimento reduzido e desequilíbrio nutricional, principalmente na absorção de cálcio. Assim, objetivou-se avaliar o efeito do enriquecimento da solução nutritiva com nitrato de cálcio em soluções preparadas com água salina na cultura da alface. Utilizou-se o delineamento inteiramente casualizado, com cinco tratamentos e quatro repetições. Os tratamentos foram representados por cinco soluções nutritivas [S1 - solução nutritiva padrão (SNP); S2 - SNP + NaCl (3,5 dS m-1); S3 - S2 + Ca(NO3)2 (50% = 6,86 mmol L-1); S4 - S2 + Ca(NO3)2 (100% = 9,15 mmol L-1); S5 - S2 + Ca (NO3)2 (150% = 11,43 mmol L-1)] em alface do grupo crespa, cv. Elba. Após o preparo das soluções nutritivas, as soluções apresentaram as seguintes condutividades elétricas: 1,8 (S1); 4,8 (S2); 5,4 (S3); 6,0 (S4); 6,6 (S5) dS m-1. Foram avaliadas variáveis de crescimento, nutrição e qualidade pós-colheita da alface. Com exceção do diâmetro do caule, número de folhas totais, pH da planta e teor de vitamina C, as demais variáveis foram afetadas pela adição extra de Ca(NO3)2 nas soluções nutritivas. A alface cv. Elba cultivada em fibra de coco é tolerante à salinidade de 4,8 dS m-1 (S2). Em condições onde o uso de água salina com 3,5 dS m-1 para o preparo da solução nutritiva é inevitável, não é recomendado o uso de doses extras de Ca(NO3)2 na cultura da alface.

https://doi.org/10.1590/1807-1929/agriambi.v27n9p712-718

Outcomes of decompressive craniectomy for malignant middle cerebral artery stroke in an academic hospital in Brazil
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Rodrigues de Oliveira, Luiz Fernando

; Camilo, Millene Rodrigues

; Franciscatto, Luisa

; Podolsky-Gondim, Guilherme Gozzoli

; Alves, Frederico Fernandes Alessio

; Martins Filho, Rui Kleber do Vale

; Dias, Francisco Antunes

; Tanaka, Koji

; Colli, Benedicto Oscar

; Pontes Neto, Octávio Marques

Arquivos de Neuro-Psiquiatria

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sep 2023, Volume 81 N. 9 Pages 778 - 784

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

Abstract Background Ischemic stroke is an important cause of death in the world. The malignant middle cerebral artery infarction (MMCAI) has mortality as high as 80% when clinically treated. In this setting, decompressive craniectomy is a life-saving measure, in spite of high morbidity among survivors. Objective To evaluate the outcomes of patients with MMCAI treated with decompressive craniectomy in a Brazilian academic tertiary stroke center. Methods A prospective stroke database was retrospectively evaluated, and all patients treated with decompressive craniectomy for MMCAI between January 2014 and December 2017 were included. The demographics and clinical characteristics were evaluated. The functional outcome, measured by the modified Rankin Scale (mRS), was assessed at hospital discharge, after 3-months and 1-year of follow-up. Results We included 53 patients on the final analysis. The mean age was 54.6 ± 11.6 years and 64.2% were males. The median time from symptoms to admission was 4.8 (3–9.7) hours and the mean time from symptoms to surgery was 36 ± 17 hours. The left hemisphere was the affected in 39.6%. The median NIHSS at admission was 20 (16–24). The in-hospital mortality was 30.2%. After a median of 337 [157–393] days, 47.1% of patients had achieved favorable outcome (mRS ≤ 4) and 39.6% had died. Conclusion Decompressive craniectomy is a life-saving measure in the setting of MMCAI, and its effects remains important in the scenario of a middle-income country in real-world situations.

Resumo Antecedentes O acidente vascular cerebral (AVC) isquêmico é uma causa importante da morte em todo o mundo. O infarto maligno da artéria cerebral média (IMACM) tem mortalidade de até 80% quando tratado clinicamente. Nesse contexto, a craniectomia descompressiva é uma medida salvadora de vidas, apesar da alta morbidade entre os sobreviventes. Objetivo Avaliar os desfechos dos pacientes com IMACM tratados com craniectomia descompressiva em um centro acadêmico terciário de AVC no Brasil. Métodos Um banco de dados prospectivo de AVC foi avaliado retrospectivamente e todos os pacientes tratados com craniectomia descompressiva para IMACM entre janeiro de 2014 e dezembro de 2017 foram incluídos. As características clínicas e demográficas foram avaliadas. Os desfechos funcionais, medidos pela escala modificada da Rankin (mRS), foram avaliados na alta hospitalar, após 3 meses e após 1 ano de seguimento. Resultados Foram incluídos 53 pacientes na análise final. A idade média foi 54,6 ± 11,6 anos e 64,2% eram homens. A mediana do tempo dos sintomas à admissão foi 4,8 (3–9,7) horas e o tempo médio dos sintomas à cirurgia foi 36 ± 17 horas. O hemisfério esquerdo foi o afetado em 39,6%. A pontuação na escala de AVC do National Institute of Health (NIHSS) à admissão foi 20 (16–24). A mortalidade hospitalar foi 30,2%. Após uma mediana de 337 (157–393) dias, 47,1% dos pacientes tinham atingido um desfecho favorável (mRS ≤ 4) e 39,6% tinham morrido. Conclusão Craniectomia descompressiva é uma medida salvadora de vidas no contexto do IMACM e seus efeitos permanecem importantes no cenário de um país em desenvolvimento em situação de vida real.

https://doi.org/10.1055/s-0043-1772602

Erro e Discrepância no Diagnóstico Radiológico
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Silva, Carlos Francisco

; Oliveira, Carlos Miguel

; Marques, Hugo

; Brito, Jorge

; Certo, Manuela

; Ferreira, Margarida Isabel

; França, Manuela

; Simões, Marta

; Morgado, Paulo Vilares

; Santos, Rosana

; Mendes, Vasco

; Carvalho, Paulo Costa

Acta Radiológica Portuguesa

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aug 2023, Volume 35 N. 2 Pages 24 - 26

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

Abstract Discrepancies between Radiology reports and their subsequent patient outcomes are not necessarily considered error or malpractice. The Portuguese College of Radiology makes some pertinent considerations on these sensitive themes, intending to frame both European and North American concepts and visions for our national reality.

Resumo Discrepâncias entre relatórios dos exames da Radiologia e seus subsequentes desfechos nos pacientes não são necessariamente considerados erro ou má prática. O Colégio de Radiologia Português tece algumas considerações pertinentes sobre estas sensíveis temáticas pretendendo enquadrar conceitos e visões quer europeias quer norte-americanas para a nossa realidade nacional.

https://doi.org/10.25748/arp.29602

Definitions, phenomenology, diagnosis, and management of the disorders of laughter and crying in amyotrophic lateral sclerosis (ALS): Consensus from ALS and Motor Neuron Disease Scientific Department of the Brazilian Academy of Neurology
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Gondim, Francisco de Assis Aquino

; Pinto, Wladimir Bocca Vieira de Rezende

; Chieia, Marco Antônio Troccoli

; Correia, Carolina da Cunha

; Cunha, Francisco Marcos Bezerra

; Dourado Jr, Mário Emílio Teixeira

; França Júnior, Marcondes Cavalcante

; Marques Júnior, Wilson

; Oliveira, Acary Souza Bulle

; Rodrigues, Cleonisio Leite

; Silva, Delson José da

; Dias-Tosta, Elza

Arquivos de Neuro-Psiquiatria

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aug 2023, Volume 81 N. 8 Pages 764 - 775

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

Abstract The spectrum of neuropsychiatric phenomena observed in amyotrophic lateral sclerosis (ALS) is wide and not fully understood. Disorders of laughter and crying stand among the most common manifestations. The aim of this study is to report the results of an educational consensus organized by the Brazilian Academy of Neurology to evaluate the definitions, phenomenology, diagnosis, and management of the disorders of laughter and crying in ALS patients. Twelve members of the Brazilian Academy of Neurology - considered to be experts in the field - were recruited to answer 12 questions about the subject. After exchanging revisions, a first draft was prepared. A face-to-face meeting was held in Fortaleza, Brazil on 9.23.22 to discuss it. The revised version was subsequently emailed to all members of the ALS Scientific Department from the Brazilian Academy of Neurology and the final revised version submitted for publication. The prevalence of pseudobulbar affect/pathological laughter and crying (PBA/PLC) in ALS patients from 15 combined studies and 3906 patients was 27.4% (N = 1070), ranging from 11.4% to 71%. Bulbar onset is a risk factor but there are limited studies evaluating the differences in prevalence among the different motor neuron diseases subtypes, including patients with and without frontotemporal dementia. Antidepressants and a combination of dextromethorphan and quinidine (not available in Brazil) are possible therapeutic options. This group of panelists acknowledge the multiple gaps in the current literature and reinforces the need for further studies.

Resumo O espectro de fenômenos neuropsiquiátricos observados na ELA é amplo e não completamente entendido. Desordens do riso e do choro estão entre as manifestações mais comuns. O objetivo deste estudo é relatar os resultados de um Consenso organizado pela Academia Brasileira de Neurologia para avaliar definições, fenomenologia, diagnóstico, e manejo dos distúrbios do riso e do choro em pacientes com ELA. Doze membros da Academia Brasileira de Neurologia – considerados experts na área – foram recrutados para responder 12 questões na temática. Depois da verificação das revisões, um primeiro manuscrito foi preparado. Após, foi realizado um encontro presencial em Fortaleza, Brasil, em 23/09/2022, para discussão do conteúdo. A versão revisada foi posteriormente enviada por e-mail para todos os membros do Departamento Científico de DNM/ELA da Academia Brasileira de Neurologia e a versão final revisada foi submetida para publicação. A prevalência da síndrome pseudobulbar em pacientes com ELA em 15 estudos combinados com 3906 pacientes foi de 27,4% (n = 1070), variando entre 11,4% e 71%. Início bulbar é um fator de risco, mas há limitados estudos avaliando as diferenças em prevalência entre os diferentes subtipos de Doença do Neurônio Motor, incluindo pacientes com e sem Demência Frontotemporal. Antidepressivos e uma combinação de dextrometorfana e quinidina (indisponíveis no Brasil) são opções terapêuticas possíveis. Esse grupo de panelistas reconhece as múltiplas demandas não atendidas na literatura atual e reforça a necessidade de futuros estudos.

https://doi.org/10.1055/s-0043-1771176

10.

Nectarine Coated with Biopolymeric Nanocapsules Containing Eugenol to Control Brown Rot
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Jacumazo, Joslaine

; Parchen, Gabriela P.

; Garcia, Meira J. B.

; Santos, Nayana C. S.

; Mio, Louise L. M. De

; Marques, Francisco A.

; Freitas, Rilton A. de

Journal of the Brazilian Chemical Society

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jul 2023, Volume 34 N. 7 Pages 1030 - 1039

Abstract: En | Text: En | PDF: En

Infections in fruits caused by fungi reduce the quantity and quality of food for human consumption, in addition to causing economic losses. In this sense, this study aimed to address the effects of eugenol nanocapsules (NCs) based on chitosan and carboxymethylcellulose in protecting nectarines against Monilinia fructicola, a brown rot agent, a worldwide important disease. NCs were prepared by layer-by-layer (LbL) self-assembly starting from an anionic template and deposition with up to two polymeric layers. The hydrodynamic diameters ranged from 158 nm (nanoemulsion), 360 nm (one polymeric layer) to 398 nm (two polymeric layers). NCs presented, during the in vitro release, the release of eugenol following a first order process. In addition to being in the region of stability (zeta potential ca. |30| mV), the capsules showed good adhesion to the nectarine surface. In relation to brown rot, the eugenol NCs with chitosan proved to be the best formulation compared to nanoemulsion and NCs with two polymeric layers for its control, increasing the probability that the fruits remain without symptoms, even after 7 days. Therefore, this study demonstrated that chitosan NCs containing eugenol could be an alternative to preserve fruit for longer periods in post-harvest.

https://doi.org/10.21577/0103-5053.20230018

11.

Brazilian consensus for diagnosis, management and treatment of hereditary transthyretin amyloidosis with peripheral neuropathy: second edition
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Pinto, Marcus Vinicius

; França Jr, Marcondes Cavalcante

; Gonçalves, Marcus Vinicius Magno

; Machado-Costa, Marcela Câmara

; Freitas, Marcos Raimundo Gomes de

; Gondim, Francisco de Assis Aquino

; Marrone, Carlo Domenico

; Martinez, Alberto Rolim Muro

; Moreira, Carolina Lavigne

; Nascimento, Osvaldo J. M.

; Covaleski, Anna Paula Paranhos

; Oliveira, Acary Souza Bulle de

; Pupe, Camila Castelo Branco

; Rodrigues, Marcia Maria Jardim

; Rotta, Francisco Tellechea

; Scola, Rosana Herminia

; Marques Jr, Wilson

; Waddington-Cruz, Márcia

Arquivos de Neuro-Psiquiatria

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mar 2023, Volume 81 N. 3 Pages 308 - 321

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

Abstract Hereditary transthyretin amyloidosis with peripheral neuropathy (ATTRv-PN) is an autosomal dominant inherited sensorimotor and autonomic polyneuropathy with over 130 pathogenic variants identified in the TTR gene. Hereditary transthyretin amyloidosis with peripheral neuropathy is a disabling, progressive and life-threatening genetic condition that leads to death in ~ 10 years if untreated. The prospects for ATTRv-PN have changed in the last decades, as it has become a treatable neuropathy. In addition to liver transplantation, initiated in 1990, there are now at least 3 drugs approved in many countries, including Brazil, and many more are being developed. The first Brazilian consensus on ATTRv-PN was held in the city of Fortaleza, Brazil, in June 2017. Given the new advances in the area over the last 5 years, the Peripheral Neuropathy Scientific Department of the Brazilian Academy of Neurology organized a second edition of the consensus. Each panelist was responsible for reviewing the literature and updating a section of the previous paper. Thereafter, the 18 panelists got together virtually after careful review of the draft, discussed each section of the text, and reached a consensus for the final version of the manuscript.

Resumo Polineuropatia amiloidótica familiar associada a transtirretina (ATTRv-PN) é uma polineuropatia sensitivo-motora e autonômica hereditária autossômica dominante com mais de 130 variantes patogênicas já identificadas no gene TTR. A ATTRv-PN é uma condição genética debilitante, progressiva e que ameaça a vida, levando à morte em ~ 10 anos se não for tratada. Nas últimas décadas, a ATTRv-PN se tornou uma neuropatia tratável. Além do transplante de fígado, iniciado em 1990, temos agora 3 medicamentos modificadores de doença aprovados em muitos países, incluindo o Brasil, e muitas outras medicações estão em desenvolvimento. O primeiro consenso brasileiro em ATTRv-PN foi realizado em Fortaleza em junho de 2017. Devido aos novos avanços nesta área nos últimos 5 anos, o Departamento Científico de Neuropatias Periféricas da Academia Brasileira de Neurologia organizou uma segunda edição do consenso. Cada panelista ficou responsável por rever a literatura e atualizar uma parte do manuscrito. Finalmente, os 18 panelistas se reuniram virtualmente após revisão da primeira versão, discutiram cada parte do artigo e chegaram a um consenso sobre a versão final do manuscrito.

https://doi.org/10.1055/s-0043-1764412

12.

Cannabis products: medical use products
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Fernandes, César Eduardo

; Dolci, José Eduardo Lutaif

; Navarro, Leonardo Sobral

; Allevato, Marcelo

; Constantino, Clóvis Francisco

; Pereira, Rodrigo Pastor Alves

; Rieder, Carlos Roberto de Mello

; Torino, Flávia

; Bernardo, Wanderley Marques

; Silva, Antônio Geraldo da

Revista da Associação Médica Brasileira

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mar 2023, Volume 69 N. 3 Pages 358 - 364

Abstract: En | Text: En | PDF: En

https://doi.org/10.1590/1806-9282.2023d693

13.

Seroprevalence of SARS-CoV-2 antibodies in schoolchildren in the city of São Paulo, 2020
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Kamioka, Gabriela Akemi

; Madalosso, Geraldine

; Albuquerque, José Olimpio Moura de

; Costa, Selma Anequini

; Ferreira, Paula Bisordi

; Sato, Ana Paula Sayuri

; Glasser, Paula Regina

; Pino, Francisco Alberto

; Burihan, Patrícia Carla Piragibe Ramos

; Carvalho, Ana Carolina Aguiar de

; Amorim, Ana Beatriz Pagliaro

; Cavazzana, Cinthya Luzia

; Aires, Caroline Cotrim

; Kataoka, Ana Paula Arruda Geraldes

; Savani, Elisa San Martin Mouriz

; Bessa, Thirsa Alvares Franco

; Aguiar, Breno Souza de

; Failla, Marcelo Antunes

; Santos, Edson Aparecido dos

; Brito, Edjane Maria Torreão

; Santos, Maria Cristina Honório dos

; Caldeira, Luiz Artur Vieira

; Silva, Solange Maria Saboia e

; Zamarco, Luiz Carlos

; Fonseca, Sandra Maria Sabino

; Lima, Marcia Maria de Cerqueira

; Marques, Ivanilda Argenau

; Mauro, Athenê Maria de Marco França

; Masi, Eduardo de

Revista de Saúde Pública

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2023, Volume 57 Suppl. 1 elocation 6s

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO OBJETIVO Estimar a soroprevalência de anticorpos do vírus SARS-CoV-2 em escolares de quatro a 14 anos de idade residentes no município de São Paulo, segundo variáveis clínicas, demográficas, epidemiológicas e sociais, durante o período de fechamento das escolas como medida de controle da covid-19. MÉTODOS Realizou-se um inquérito sorológico em setembro de 2020 com amostra aleatória estratificada por tipo de rede de ensino (pública municipal, pública estadual e privada). Foi coletada amostra de sangue venoso utilizando-se o teste de imunoensaio de fluxo lateral da fabricante Wondfo para detecção de anticorpos totais contra o vírus SARS-CoV-2. Aplicaram-se questionários semiestruturados para o levantamento de dados clínicos, demográficos, sociais e epidemiológicos. RESULTADOS A soroprevalência de anticorpos do vírus SARS-CoV-2 em escolares foi de 16,6% (IC95% 15,4–17,8). O estudo encontrou soroprevalências mais elevadas na rede pública municipal (18,5%; IC95% 16,6–20,6) e estadual (16,2%; IC95% 14,4–18,2) em relação à rede privada (11,7; IC95% 10,0–13,7) e entre escolares da raça/cor preta e parda (18,4%; IC95% 16,8–20,2) e no estrato social mais vulnerável (18,5%; IC95% 16,9–20,2). A pesquisa identificou menores soroprevalências nos escolares que relataram seguir as medidas recomendadas de proteção contra a covid-19. CONCLUSÃO A soroprevalência de anticorpos contra o vírus SARS-CoV-2 atinge principalmente os escolares socialmente mais vulneráveis. Este estudo pode contribuir para embasar políticas públicas que reforcem a importância da suspensão das aulas presenciais e da necessidade de estratégias de medidas de proteção e acompanhamento do status sorológico daqueles que ainda não foram contemplados no calendário vacinal.

ABSTRACT OBJECTIVE To estimate seroprevalence of SARS-CoV-2 antibodies in schoolchildren aged 4 to 14 years living in the city of São Paulo, according to clinical, demographic, epidemiological, and social variables, during the school closure period as a measure against covid-19 spread. METHODS A serological survey was made in September 2020 with a random sample stratified by school system (municipal public, state public and private) type. A venous blood sample was collected using the Wondfo SARS-CoV-2 Antibody Test (lateral flow method) for detection of total SARS-CoV-2 virus antibodies. Semi-structured questionnaires were applied to collect clinical, demographic, social, and epidemiological data. RESULTS Seroprevalence of SARS-CoV-2 antibodies in schoolchildren was of 16.6% (95%CI 15.4–17.8). The study found higher seroprevalence in the municipal (18.5%; 95%CI 16.6–20.6) and state (16.2%; 95%CI 14.4–18.2) public school systems compared to the private school system (11.7; 95%CI 10.0–13.7), among black and brown students (18.4%; 95%CI 16.8–20.2) and in the most vulnerable social stratum (18.5 %;95%CI 16.9–20.2). Lower seroprevalence was identified in schoolchildren who reported following the recommended protective measures against covid-19. CONCLUSION Seroprevalence of SARS-CoV-2 antibodies is found mainly in the most socially vulnerable schoolchildren. This study can contribute to support public policies that reinforce the importance of suspending face-to-face classes and developing strategies aimed at protective measures and monitoring of the serological status of those who have not yet been included in the vaccination schedule.

https://doi.org/10.11606/s1518-8787.2023057004782

14.

Covid-19 hospital mortality using spatial hierarchical models: cohort design with 74,994 registers
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Chiaravalloti Neto, Francisco

; Bermudi, Patricia Marques Moralejo

; Aguiar, Breno Souza de

; Failla, Marcelo Antunes

; Barrozo, Ligia Vizeu

; Toporcov, Tatiana Natasha

Revista de Saúde Pública

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2023, Volume 57 Suppl. 1 elocation 2s

Abstract: En | Text: En | PDF: En

ABSTRACT OBJECTIVE To investigate the relationship between covid-19 hospital mortality and risk factors, innovating by considering contextual and individual factors and spatial dependency and using data from the city of São Paulo, Brazil. METHODS The study was performed with a spatial hierarchical retrospective cohort design using secondary data (individuals and contextual data) from hospitalized patients and their geographic unit residences. The study period corresponded to the first year of the pandemic, from February 25, 2020 to February 24, 2021. Mortality was modeled with the Bayesian context, Bernoulli probability distribution, and the integrated nested Laplace approximations. The demographic, distal, medial, and proximal covariates were considered. RESULTS We found that per capita income, a contextual covariate, was a protective factor (odds ratio: 0.76 [95% credible interval: 0.74–0.78]). After adjusting for income, the other adjustments revealed no differences in spatial dependence. Without income inequality in São Paulo, the spatial risk of death would be close to one in the city. Other factors associated with high covid-19 hospital mortality were male sex, advanced age, comorbidities, ventilation, treatment in public healthcare settings, and experiencing the first covid-19 symptoms between January 24 and February 24, 2021. CONCLUSIONS Other than sex and age differences, geographic income inequality was the main factor responsible for the spatial differences in the risk of covid-19 hospital mortality. Investing in public policies to reduce socioeconomic inequities, infection prevention, and other intersectoral measures should focus on lower per capita income, to control covid-19 hospital mortality.

https://doi.org/10.11606/s1518-8787.2023057004652

15.

Variabilidade espacial intraurbana da mortalidade por câncer de mama e do colo do útero no município de São Paulo: análise dos fatores associados
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Aguiar, Breno Souza de

; Pellini, Alessandra Cristina Guedes

; Rebolledo, Elizabeth Angélica Salinas

; Ribeiro, Adeylson Guimarães

; Diniz, Carmen Simone Grilo

; Bermudi, Patricia Marques Moralejo

; Failla, Marcelo Antunes

; Baquero, Oswaldo Santos

; Chiaravalloti-Netto, Francisco

Revista Brasileira de Epidemiologia

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2023, Volume 26 elocation e230008

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Objetivo: Identificar a variabilidade espacial da mortalidade por câncer de mama e colo do útero e avaliar fatores associados à mortalidade por esses cânceres no município de São Paulo. Métodos: Entre 2009 e 2016 foram registrados, no Sistema de Informações sobre Mortalidade, 10.124 óbitos por câncer de mama e 2.116 óbitos por câncer do colo do útero em mulheres com 20 anos e mais. Os registros foram geocodificados por endereço de residência e agregados segundo território adstrito. Foram realizadas modelagens de regressão espacial utilizando-se a abordagem bayesiana com estrutura de Besag-York-Mollié para verificar a associação dos óbitos com indicadores selecionados. Resultados: As taxas de mortalidade por esses cânceres apresentaram padrões espaciais inversos. As variáveis associadas à mortalidade por câncer de mama foram: tempo de deslocamento para o trabalho entre uma e duas horas (risco relativo — RR 0,97; intervalo de credibilidade — IC95% 0,93–1,00); mulheres responsáveis pelo domicílio (RR 0,97; IC95% 0,94–0,99) e óbitos por câncer de mama ocorridos em estabelecimentos privados (RR 1,04; IC95% 1,00–1,07). À mortalidade por câncer do colo do útero, estiveram associados: tempo de deslocamento para o trabalho entre meia e uma hora (RR 0,92; IC95% 0,87–0,98); rendimento domiciliar até três salários-mínimos (RR 1,27; IC95% 1,18–1,37); e razão de menores de um ano em relação à população feminina de 15 a 49 anos (RR 1,09; IC95% 1,01–1,18). Conclusão: Foram calculados os RR preditos para a mortalidade por esses cânceres, que estiveram associados às condições socioeconômicas das áreas de abrangência.

ABSTRACT Objective: To identify spatial variability of mortality from breast and cervical cancer and to assess factors associated in the city of São Paulo. Methods: Between 2009 and 2016, 10,124 deaths from breast cancer and 2,116 deaths from cervical cancer were recorded in the Mortality Information System among women aged 20 years and over. The records were geocoded by address of residence and grouped according to Primary Health Care coverage areas. A spatial regression modeling was put together using the Bayesian approach with a Besag-York-Mollié structure to verify the association of deaths with selected indicators. Results: Mortality rates from these types of cancer showed inverse spatial patterns. These variables were associated with breast cancer mortality: travel time between one and two hours to work (RR – relative risk: 0.97; 95%CI – credible interval: 0.93–1.00); women being the head of the household (RR 0.97; 95%CI 0.94–0.99) and deaths from breast cancer in private health institutions (RR 1.04; 95%CI 1.00–1.07). The following variables were associated with mortality from cervical cancer: travel time to work between half an hour and one hour (RR 0.92; 95%CI 0.87–0.98); per capita household income of up to 3 minimum wages (RR 1.27; 95%CI 1.18–1.37) and ratio of children under one year of age related to the female population aged 15 to 49 years (RR 1.09; 95%CI 1.01–1.18). Conclusion: The predicted RR for mortality from these cancers were calculated and associated with the socioeconomic conditions of the areas covered.

https://doi.org/10.1590/1980-549720230008.2

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