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Exposição a agrotóxicos e o risco de tumores do Sistema Nervoso Central em crianças: revisão sistemática com metanálise
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Mota, Anne Lívia Cavalcante

; Barbosa, Isadora Marques

; Rodrigues, Andrea Bezerra

; Chaves, Edna Maria Camelo

; Almeida, Paulo César de

Ciência & Saúde Coletiva

Journal Metrics
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sep 2023, Volume 28 N. 9 Pages 2583 - 2594

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Os tumores do Sistema Nervoso Central (SNC) representam mais da metade das neoplasias infantis malignas que acometem crianças. Objetivou-se analisar o risco de exposição a agrotóxicos relacionado com o desenvolvimento de tumores do SNC em crianças. Realizou-se uma revisão sistemática da literatura nas bases de dados PubMed/MEDILINE, Embase, Web of Science, Scopus e CINAHL. Foram incluídos estudos de coorte e caso-controle sobre o desenvolvimento de tumores do SNC (todos os tipos histológicos do grupo III Classificação de Câncer Infantil) decorrentes da exposição a agrotóxicos em crianças de 0-14 anos. Na metanálise utilizou-se o modelo de efeito aleatório e o método estatístico de Mantel-Haenszel. A Razão de Chances (RC) ou Odds Ratio (OR) foi a medida de associação aplicada. A revisão foi registrada no International Prospective Register of Systematic Reviews (PROSPERO) sob o número CRD42021209354. A busca identificou 1.158 estudos, dos quais 14 compuseram a revisão. Verificou-se evidência de associação entre o desenvolvimento de astrocitomas e a exposição a todas as classes de pesticidas (OR 1,50; IC95% 1,15-1,96; p=0,03). A síntese dos resultados apontou para uma relação da exposição aos agrotóxicos com o desfecho de alguns tipos histológicos de tumores do SNC na infância.

Abstract Central Nervous System (CNS) tumors represent more than half of all childhood malignant neoplasms. The aim of this study was to determine the relationship between environmental exposure to pesticides and the development of CNS tumors in children. We conducted a systematic review of the literature in the PubMed/MEDILINE, Embase, Web of Science, Scopus, and CINAHL databases. The inclusion criteria were cohort and case-control studies investigating the association between exposure to pesticides and CNS tumors (all histological types included in group III of the WHO Classification of Childhood Cancer) in children aged 0-14 years. The meta-analysis was performed using a random effects model and the Mantel-Haenszel method. Strength of association was measured using odds ratios (OR). The review was registered in the International Prospective Register of Systematic Reviews (PROSPERO) under identification number CRD42021209354. The search identified 1,158 studies, 14 of which were included in the review. There was evidence of an association between the development of astrocytomas and exposure to all classes of pesticides (OR 1.50; 95%CI 1.15-1.96; p=0.03). The synthesis of the evidence pointed to a relationship between exposure to pesticides and some histological types of CNS tumors in childhood.

https://doi.org/10.1590/1413-81232023289.00262023

Exposição a agrotóxicos e o risco de tumores do Sistema Nervoso Central em crianças: revisão sistemática com metanálise
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Mota, Anne Lívia Cavalcante

; Barbosa, Isadora Marques

; Rodrigues, Andrea Bezerra

; Chaves, Edna Maria Camelo

; Almeida, Paulo César de

Ciência & Saúde Coletiva

Journal Metrics
- Sobre o periódico
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sep 2023, Volume 28 N. 9 Pages 2583 - 2594

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

https://doi.org/10.1590/1413-81232023289.00262023

[SciELO Preprints] - Evaluation of the performance indicators of the Previne Brasil Program in the Massif of Baturité: Chronic Diseases.
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Linard, Andrea Gomes Silva, Antônia Carla Gomes Sancho, Aida Texeira Marques, Jarom Kepri de Sousa Martins, Larissa Santiago

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Publication date: 2023-07-13

Abstract: En Pt

Objective: to evaluate the results of performance indicators 6 (proportion of people with hypertension, with consultation and blood pressure checked in the semester) and 7 (proportion of people with diabetes mellitus, with consultation and glycated hemoglobin requested in the semester) of the Previne Brasil Program in the Massif of Baturité, located in Ceará in the period from 2020 to the year 2023. Methods: Cross-sectional study with a quantitative approach Results: The Maciço de Baturité region has 136 primary health care units in active status and registered in the National Register of Health Establishments (CNES), with a total of 99 Family Health teams (eSF), displaying a coverage indicator of 100% eSF. However, the performance indicators of the Previne Brasil program showed inadequate results. Indicator 6 did not reach the target of 50% coverage in the years 2020 to 2022 and indicator 7 reached the target only in 2021, however it shows a downward trend in 2022. Conclusion: the coverage of the indicators is unsatisfactory, in view of the predominance of quarters where the targets established for the indicators are not achieved. However, the study reveals that the coverage rate of Family Health teams is adequate in the thirteen municipalities evaluated. Thus, the research expresses the need to review the profile of care for patients with chronic non-communicable diseases.

Objetivo: avaliar os resultados dos indicadores de desempenho 6 (proporção de pessoas com hipertensão, com consulta e pressão arterial aferida no semestre) e 7 (proporção de pessoas com diabetes mellitus, com consulta e hemoglobina glicada solicitada no semestre) do Programa Previne Brasil no Maciço de Baturité, situado no Ceará no período de 2020 ao ano de 2023. Métodos: Estudo transversal de abordagem quantitativa Resultados: A região do Maciço de Baturité possui 136 unidades de atenção primária à saúde em situação ativa e registradas no Cadastro Nacional de Estabelecimentos de Saúde (CNES), com o total 99 equipes de Saúde da Família (eSF), exibindo um indicador de cobertura de eSF de 100%. Contudo, os indicadores de desempenho do programa Previne Brasil apresentaram resultados inadequados. O indicador 6 não alcançou a meta de 50% de cobertura nos anos de 2020 a 2022 e o indicador 7 atingiu a meta somente no ano de 2021, todavia apresenta uma tendência de queda em 2022.  Conclusão: a cobertura dos indicadores é insatisfatória, em observância ao predomínio de quadrimestres onde as metas estabelecidas para os indicadores não são alcançadas. No entanto, o estudo revela que a taxa de cobertura de equipes de Saúde da Família encontra-se adequada nos treze municípios avaliados. Assim, a pesquisa expressa a necessidade de revisão no perfil de atendimento a pacientes com doenças crônicas não transmissíveis. 

https://doi.org/10.1590/SciELOPreprints.6322

Neuropsychological and quality of life outcomes in PKU patients: expert recommendations of assessment tools in Brazil
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Schwartz, Ida Vanessa Doederlein

; Quesada, Andrea Amaro

; Ribeiro, Erlane Marques

; Martins, Ana Maria

; Vilela, Daniel Reda Fenga

; Pessoa, André

Arquivos de Neuro-Psiquiatria

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jul 2023, Volume 81 N. 7 Pages 685 - 695

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

Abstract Background Phenylketonuria (PKU) is an inborn error of metabolism caused by deficient activity of phenylalanine hydroxylase. In Brazil, the National Neonatal Screening Program enables early treatment of patients with PKU, which prevents them from developing severe neurological damage and mental disabilities. However, between 20 and 30% of early-treated patients with PKU present focal cognitive deficits, including deficits in working memory, processing speed, and psychiatric symptoms such as anxiety, depression, and attention deficit hyperactivity disorder (ADHD). Therefore, age-specific neuropsychiatric and cognitive tests are important components of PKU patient care. To date, there are no officially approved guidelines or recommendations of tools in Portuguese validated for use in Brazil that could be applied to assess these parameters in patients with PKU. Objective To recommend tools validated for use in Brazil that can be used in daily clinical practice to assess quality of life and neuropsychological outcomes in patients with PKU. Methods Six Brazilian experts discussed about eligible tools based on their clinical experience, the feasibility of their use in clinical routines, and their availability in public health services. Before the meeting, an independent review of the literature was conducted to identify the currently validated tools in Brazil, using the MEDLINE and SciELO databases. Results The experts recommended nine tools to assess quality of life (Peds-QL, SF-36 or WHOQOL-bref), executive function (BRIEF or Bayley-III), IQ (SONR 2½-7[a] or WASI) and ADHD (MTA-SNAP-IV and ASRS). Conclusions These instruments may be easily incorporated into clinical practice and improve the quality of multidisciplinary care of patients with PKU.

Resumo Antecedentes A fenilcetonúria (PKU) é um erro inato do metabolismo causado pela atividade deficiente da fenilalanina hidroxilase. No Brasil, o Programa Nacional de Triagem Neonatal permite o tratamento precoce de pacientes com PKU, o que os impede de desenvolver danos neurológicos e deficiências intelectuais graves. No entanto, já foi descrito que de 20 a 30% dos pacientes tratados precocemente com PKU apresentam déficits cognitivos focais, incluindo déficits na memória de trabalho, velocidade de processamento e sintomas psiquiátricos como ansiedade, depressão e Transtorno de Déficit de Atenção e Hiperatividade (TDAH). Neste sentido, testes neuropsiquiátricos e cognitivos são componentes importantes no cuidado destes pacientes. Atualmente, não existe um compêndio científico ou recomendações de ferramentas validadas em português para avaliar a saúde mental em pacientes brasileiros com PKU. Objetivo Recomendar ferramentas validadas localmente para avaliar a qualidade de vida e aspectos neuropsicológicos de pacientes com PKU. Métodos Seis especialistas brasileiros discutiram as ferramentas mais apropriadas com base em suas experiências clínicas, a viabilidade de realizar as avaliações na rotina clínica, e o acesso às ferramentas na saúde pública. Antes da reunião, foi realizada uma revisão independente da literatura para identificar as ferramentas validadas no Brasil, utilizando as bases de dados MEDLINE e Scielo. Resultados Os especialistas recomendaram nove ferramentas para avaliar a qualidade de vida (Peds-QL, SF-36 ou WHOQOL-bref), função executiva (BRIEF ou Bayley-III), QI (SONR 2½-7[a] ou WASI) e TDAH (MTA-SNAP-IV e ASRS). Conclusões Estes instrumentos podem ser facilmente incorporados na prática clínica e melhorar a qualidade dos cuidados multidisciplinares dos pacientes com PKU.

https://doi.org/10.1055/s-0043-1768677

Clinical and laboratory differences between chromosomal and undefined causes of non-obstructive azoospermia: A retrospective study
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Riccetto, Luísa

; Vieira, Tarsis Paiva

; Viguetti-Campos, Nilma Lucia

; Mazzola, Tais Nitsch

; Guaragna, Mara Sanches

; Fabbri-Scallet, Helena

; Mello, Maricilda Palandi de

; Marques-de-Faria, Antonia Paula

; Maciel-Guerra, Andrea Trevas

; Guerra Junior, Gil

Sao Paulo Medical Journal

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2023, Volume 141 N. 4 elocation e2022281

Abstract: En | Text: En | PDF: En

ABSTRACT BACKGROUND: Knowledge of clinical and laboratory differences between chromosomal and undefined causes aids etiological research on non-obstructive azoospermia. OBJECTIVE: Compare clinical and laboratory differences between men with non-obstructive azoospermia due to chromosomal anomalies versus undefined causes DESIGN AND SETTING: A cross-sectional retrospective study conducted at a public university hospital in Campinas (Brazil) METHODS: All men aged 20–40 years with non-obstructive azoospermia were included in the analysis. RESULTS: The 107 cases included 14 with Klinefelter syndrome (KS) (13%), 1 with mosaic KS, 4 with sex development disorders (2 testicular XX, 1 NR5A1 gene mutation, and 1 mild androgen insensitivity syndrome) (4%), 9 with other non-obstructive azoospermia etiologies (8%), and 79 with undefined causes. The 22 chromosomal anomaly cases (14 KS, 1 mosaic KS, 2 testicular XX, 4 sex chromosome anomalies, and 1 autosomal anomaly) were compared with the 79 undefined cause cases. The KS group had lower average testicular volume, shorter penile length, and lower total testosterone levels but greater height, arm span, serum luteinizing hormone (LH) and follicle stimulating hormone (FSH) levels, and gynecomastia frequency (absent in the undefined group and affecting more than half of the KS group). Patients with testicular XX DSD had LH, FSH, and penile length data intermediate between the KS and undefined cause groups, testicular volume similar to the KS group, and other data similar to the undefined group. CONCLUSION: Clinical and laboratory data differentiate men with non-obstructive azoospermia and chromosomal anomalies, particularly KS and testicular XX, from those with undefined causes or other chromosomal anomalies.

https://doi.org/10.1590/1516-3180.2022.0281.r1.30082022

Health-related quality of life in children with cerebral palsy associated with congenital Zika infection
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Marques, Fernanda Jordão Pinto

; Carvalho, Alessandra Lemos de

; Borigato, Eliana Valverde Magro

; Oliveira, Luiz Felipe Vieira de

; Duarte, Lenamaris Mendes Rocha

; Silva, Adriana Goncalves da

; Amarante, Claret Luiz Dias

; Pereira, Laura Jácome de Melo

; Tavares, Elise Ferreira

; Costa, Lilian Gleice de Sena da

; Alcântara, Carolina Alves Rezende

; Salinas, Andrea Nakamura

; Pinto, Fernanda de Lourdes da Cunha

; Alcântara, Gerliane Carvalho de

; Utsch, Fabiana

; Silva, Cinthia Ramos Diniz

; Reis, Dirlene Araujo dos

; Bessa, Wilerson Marques

; Dutra, Rafaela Christine

; Ventura, Paloma

; Oliveira, Tatiana Souza

Revista Paulista de Pediatria

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2023, Volume 41 elocation e2022016

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

Abstract Objective: To describe the health-related quality of life (QOL) in children with cerebral palsy (CP) associated with congenital Zika infection. Methods: Cross-sectional study of a consecutive series of children, followed in a referral multicentric rehabilitation network in Brazil. We invited the caregivers to respond to the Brazilian version of the Caregiver Priorities & Child Health Index of Life with Disabilities (CPCHILDTM) questionnaire. Statistical analysis was performed with the Statistical Package for the Social Sciences (SPSS) 26.0™. We used absolute and relative frequencies for categorical variables and mean and standard deviation for continuous variables. Results: The sample consisted of 193 children, at mean age of 50.3±7.6 months. We observed a predominance of children with cerebral palsy (CP) with Gross Motor Function Classification System (GMFCS) level V (93.7%). Epilepsy (88.4%) was the most common comorbidity. CPCHILDTM mean scores were activities of daily living (ADL)/personal care 43.2±12.6; positioning, transferring and mobility 33.7±16.5; comfort and emotions 84.4±15.2; communication and social interaction (CoSI) 48.2±24.3; health 70.9±17.1; and overall quality of life (OQOL) 72.1±17.1. Total score was 54.8±11.3. Conclusions: Among children with cerebral palsy (CP) related to congenital Zika syndrome, the quality of life (QOL) scores were very similar to other populations with cerebral palsy (CP). The activities of positioning, transferring and mobility had the greatest impact on health-related quality of life (QOL). Rehabilitation strategies and public policies should prioritize aspects related to mobility for this population.

RESUMO Objetivo: Descrever a qualidade de vida relacionada à saúde em crianças com paralisia cerebral associada à infecção congênita pelo zika. Métodos: Estudo transversal de série consecutiva de casos de crianças acompanhadas em uma rede multicêntrica de reabilitação no Brasil. Convidamos o(s) cuidador(es) a responder à versão brasileira do Caregiver Priorities & Child Health Index of Life with Disabilities (CPCHILDTM). A análise estatística foi realizada com o pacote estatístico Statistical Package for the Social Sciences (SPSS) 26.0™. Para variáveis categóricas, foram utilizadas frequências absolutas e relativas e, para variáveis contínuas, média e desvio padrão. Resultados: Cento e noventa e três crianças, com idade média de 50,3±7,6 meses, foram incluídas. Observou-se predomínio de crianças com paralisia cerebral Gross Motor Function Classification System (GMFCS) nível V (93,7%). Epilepsia (88,4%) foi a comorbidade mais comum. As pontuações médias do CPCHILDTM foram: atividades de vida diária/cuidados pessoais 43,2±12,6; posicionamento, transferência e mobilidade 33,7±16,5; conforto e emoções 84,4±15,2; comunicação e interação social 48,2±24,3; saúde 70,9±17,1; e qualidade de vida geral 72,1±17,1. A pontuação total foi 54,8±11,3. Conclusões: Entre as crianças com paralisia cerebral relacionada à síndrome do zika congênita, as atividades de posicionamento, transferência e mobilidade tiveram maior impacto na qualidade de vida relacionada à saúde, semelhantemente a outras etiologias de paralisia cerebral. As estratégias de reabilitação e as políticas públicas devem priorizar os aspectos relacionados à mobilidade dessa população.

https://doi.org/10.1590/1984-0462/2023/41/2022016

Occurrence and preventability of adverse events in hospitals: a retrospective study
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Lima Júnior, Antônio José de

; Zanetti, Ariane Cristina Barboza

; Dias, Bruna Moreno

; Bernardes, Andrea

; Gastaldi, Francielly Marques

; Gabriel, Carmen Silvia

Revista Brasileira de Enfermagem

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2023, Volume 76 N. 3 elocation e20220025

Abstract: En Es Pt | Text: En Es Pt | PDF: En | PDF: Es | PDF: Pt

ABSTRACT Objectives: to analyze the incidence of preventable adverse events related to health care in adult patients admitted to public hospitals in Brazil. Methods: observational, analytical, retrospective study based on medical records review. Results: medical records from 370 patients were evaluated, 58 of whom had at least one adverse event. The incidence of adverse events corresponded to 15.7%. Adverse events were predominantly related to healthcare-related infection (47.1%) and procedures (24.5%). Regarding the adverse event severity, 13.7% were considered mild, 51.0% moderate, and 35.3% severe. 99% of adverse events were classified as preventable. Patients admitted to the emergency room had a 3.73 times higher risk for adverse events. Conclusions: this study’s results indicate a high incidence of avoidable adverse events and highlight the need for interventions in care practice.

RESUMEN Objetivos: analizar la incidencia de eventos adversos evitables relacionados al cuidado de la salud en pacientes adultos internados en hospitales públicos brasileños. Métodos: estudio observacional, analítico, retrospectivo, basado en la revisión de historias clínicas. Resultados: se evaluaron las historias clínicas de 370 pacientes, 58 de los cuales sufrieron al menos un evento adverso. La incidencia de eventos adversos correspondió al 15,7%. Los eventos adversos estaban relacionados, principalmente, con: infecciones por asistencia sanitaria (47,1%) y procedimientos (24,5%). Respecto a la gravedad de los eventos adversos, el 13,7% era leve, el 51%, moderado y el 35,3%, grave. Se clasificó como evitable el 99% de los eventos adversos. Los pacientes ingresados en urgencias presentaron un riesgo 3,73 veces mayor de aparición de eventos adversos. Conclusiones: los resultados de este estudio señalan una incidencia elevada de eventos adversos evitables y resaltan la necesidad de intervenciones en la práctica asistencial.

RESUMO Objetivos: analisar a incidência de eventos adversos evitáveis relacionados ao cuidado em saúde em pacientes adultos internados em hospitais públicos brasileiros. Métodos: estudo observacional, analítico, de corte retrospectivo, baseado na revisão de prontuários. Resultados: avaliaram-se prontuários de 370 pacientes, dos quais 58 sofreram pelo menos um evento adverso. A incidência de eventos adversos correspondeu a 15,7%. Os eventos adversos foram vinculados: à infecção relacionada à assistência à saúde (47,1%) e a procedimentos (24,5%), predominantemente. No que tange à gravidade dos eventos adversos, averiguou-se que 13,7% foram considerados leves, 51,0%, moderados e 35,3%, graves. Classificou-se como evitáveis 99% dos eventos adversos. Pacientes internados em caráter de urgência apresentaram risco 3,73 vezes maior para a ocorrência de um evento adverso. Conclusões: os resultados deste estudo apontam elevada incidência de eventos adversos evitáveis e contribuem para evidenciar a necessidade de intervenções na prática assistencial.

https://doi.org/10.1590/0034-7167-2022-0025

Posicionamento sobre Doença Isquêmica do Coração – A Mulher no Centro do Cuidado – 2023
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Oliveira, Gláucia Maria Moraes de

; Almeida, Maria Cristina Costa de

; Rassi, Daniela do Carmo

; Bragança, Érika Olivier Vilela

; Moura, Lidia Zytynski

; Arrais, Magaly

; Campos, Milena dos Santos Barros

; Lemke, Viviana Guzzo

; Avila, Walkiria Samuel

; Lucena, Alexandre Jorge Gomes de

; Almeida, André Luiz Cerqueira de

; Brandão, Andréa Araujo

; Ferreira, Andrea Dumsch de Aragon

; Biolo, Andreia

; Macedo, Ariane Vieira Scarlatelli

; Falcão, Breno de Alencar Araripe

; Polanczyk, Carisi Anne

; Lantieri, Carla Janice Baister

; Marques-Santos, Celi

; Freire, Claudia Maria Vilas

; Pellegrini, Denise

; Alexandre, Elizabeth Regina Giunco

; Braga, Fabiana Goulart Marcondes

; Oliveira, Fabiana Michelle Feitosa de

; Cintra, Fatima Dumas

; Costa, Isabela Bispo Santos da Silva

; Silva, José Sérgio Nascimento

; Carreira, Lara Terra F.

; Magalhães, Lucelia Batista Neves Cunha

; Matos, Luciana Diniz Nagem Janot de

; Assad, Marcelo Heitor Vieira

; Barbosa, Marcia M.

; Silva, Marconi Gomes da

; Rivera, Maria Alayde Mendonça

; Izar, Maria Cristina de Oliveira

; Costa, Maria Elizabeth Navegantes Caetano

; Paiva, Maria Sanali Moura de Oliveira

; Castro, Marildes Luiza de

; Uellendahl, Marly

; Oliveira Junior, Mucio Tavares de

; Souza, Olga Ferreira de

; Costa, Ricardo Alves da

; Coutinho, Ricardo Quental

; Silva, Sheyla Cristina Tonheiro Ferro da

; Martins, Sílvia Marinho

; Brandão, Simone Cristina Soares

; Buglia, Susimeire

; Barbosa, Tatiana Maia Jorge de Ulhôa

; Nascimento, Thais Aguiar do

; Vieira, Thais

; Campagnucci, Valquíria Pelisser

; Chagas, Antonio Carlos Palandri

Arquivos Brasileiros de Cardiologia

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2023, Volume 120 N. 7 elocation e20230303

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

https://doi.org/10.36660/abc.20230303

Cultural adaptation and validation of the Brazilian Portuguese version of the PROactive Physical Activity in COPD-clinical visit instrument for individuals with COPD
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Santana, André Vinicius

; Fontana, Andrea Daiane

; Almeida, Rafaela Cristina de

; Mantoani, Leandro Cruz

; Camillo, Carlos Augusto

; Furlanetto, Karina Couto

; Rodrigues, Fátima

; Cruz, Joana

; Marques, Alda

; Jácome, Cristina

; Demeyer, Heleen

; Dobbels, Fabienne

; Garcia-Aymerich, Judith

; Troosters, Thierry

; Hernandes, Nidia Aparecida

; Pitta, Fabio

Jornal Brasileiro de Pneumologia

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2023, Volume 49 N. 4 elocation e20220372

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

ABSTRACT Objective: To adapt the PROactive Physical Activity in COPD-clinical visit (C-PPAC) instrument to the cultural setting in Brazil and to determine the criterion validity, test-retest reliability agreement, and internal consistency of this version. Methods: A protocol for cultural adaptation and validation was provided by the authors of the original instrument and, together with another guideline, was applied in a Portuguese-language version developed by a partner research group from Portugal. The adapted Brazilian Portuguese version was then cross-sectionally administered twice within a seven-day interval to 30 individuals with COPD (57% were men; mean age was 69 ± 6 years; and mean FEV1 was 53 ± 18% of predicted) to evaluate internal consistency and test-retest reliability. Participants also completed the International Physical Activity Questionnaire (IPAQ), the modified Medical Research Council scale, the COPD Assessment Test, and Saint George’s Respiratory Questionnaire to evaluate criterion validity. Results: The C-PPAC instrument showed good internal consistency and excellent test-retest reliability: “amount” domain = 0.87 (95% CI, 0.73-0.94) and “difficulty” domain = 0.90 (95% CI, 0.76-0.96). Bland & Altman plots, together with high Lin’s concordance correlation coefficients, reinforced that agreement. Criterion validity showed moderate-to-strong correlations of the C-PPAC with all of the other instruments evaluated, especially with the IPAQ (rho = −0.63). Conclusions: The Brazilian Portuguese version of the C-PPAC is a reliable and valid instrument for evaluating the experience of Brazilian individuals with COPD with their physical activity in daily life.

RESUMO Objetivo: Adaptar o instrumento PROactive Physical Activity in COPD - clinical visit (C-PPAC) ao contexto cultural brasileiro e determinar a validade de critério, concordância da confiabilidade teste-reteste e consistência interna dessa versão. Métodos: Um protocolo de adaptação cultural e validação foi fornecido pelos autores do instrumento original e, juntamente com outra diretriz, foi aplicado em uma versão em português desenvolvida por um grupo de pesquisa parceiro de Portugal. A versão brasileira adaptada foi então aplicada transversalmente duas vezes, com intervalo de sete dias, em 30 indivíduos com DPOC (57% de homens; média de idade de 69 ± 6 anos; e média do VEF1 de 53 ± 18% do previsto) para avaliação da consistência interna e da confiabilidade teste-reteste. Os participantes também responderam ao International Physical Activity Questionnaire (IPAQ), à escala modificada do Medical Research Council, ao COPD Assessment Test e ao Saint George’s Respiratory Questionnaire para avaliação da validade de critério. Resultados: O instrumento C-PPAC apresentou boa consistência interna e excelente confiabilidade teste-reteste: domínio “quantidade” = 0,87 (IC95%: 0,73-0,94) e domínio “dificuldade” = 0,90 (IC95%: 0,76-0,96). As disposições gráficas de Bland-Altman, juntamente com os altos coeficientes de correlação de concordância de Lin, reforçaram essa concordância. A validade de critério mostrou correlações moderadas a fortes do instrumento C-PPAC com todos os outros instrumentos avaliados, principalmente com o IPAQ (rho = −0,63). Conclusões: A versão brasileira do instrumento C-PPAC é uma ferramenta confiável e válida para avaliar a experiência de indivíduos brasileiros com DPOC em relação à sua atividade física na vida diária.

https://doi.org/10.36416/1806-3756/e20220372

10.

Evaluation of potential biomaterials for application in guide bone regeneration from Bacterial Nanocellulose/Hydroxyapatite
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Gaulke, Elouise

; Garcia, Michele Cristina Formolo

; Segat, Bruna

; Apati, Giannini Pasiznick

; Schneider, Andréa Lima dos Santos

; Pezzin, Ana Paula Testa

; Cesca, Karina

; Porto, Luismar Marques

Polímeros

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2023, Volume 33 N. 3 elocation e20230034

Abstract: En | Text: En | PDF: En

Abstract Bacterial nanocellulose (BNC) membranes have interconnected porous nanostructures and excellent biocompatibility. Functionalizing these with calcium phosphate sources and metal ions confers optimized properties to the biomaterial. This study aims to synthesize BNC membranes, functionalize them with copper and magnesium apatites, characterize and evaluate their cytotoxicity and antimicrobial potential. Membranes were synthesized for 8 days in Mannitol Medium. The biocomposite production was by immersion cycles. The biocomposites were characterized by porosity and swelling capacity, Fourier transforms infrared spectroscopy (FTIR), scanning electron microscopy (SEM), thermogravimetric analysis (TGA), antimicrobial properties and cytotoxicity assays. The FTIR and SEM results showed that phosphate groups were incorporated into the BNC. The TGA analysis also indicated the incorporation of the inorganic phase. The membrane functionalization with Cu promoted the antimicrobial properties of the biomaterial. However, functionalization with Mg had a more positive behavior on cell viability, proving to be more suitable for use as an implantable material.

https://doi.org/10.1590/0104-1428.20220121

11.

Acceptability of short message service (SMS) as a tool for malaria treatment adherence in the Brazilian Amazon: a qualitative study SMS (SMS Amazon
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Rodovalho, Sheila

; Dias, Ádila Liliane Barros

; Ade, Maria Paz

; Saint-Gerons, Diego Macias

; Castro, Jose Luis

; Beratarrechea, Andrea

; Murta, Felipe Leão Gomes

; Santos, Alicia Cacau Patrine dos

; Marques, Leonardo Lincoln Gomes

; Sampaio, Vanderson Souza

; Baia-da-Silva, Djane Clarys

; Monteiro, Wuelton Marcelo

Revista da Sociedade Brasileira de Medicina Tropical

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2023, Volume 56 elocation e0616-2022

Abstract: En | Text: En | PDF: En

ABSTRACT Background: Malaria is one of the leading causes of morbidity worldwide, and patient adherence to prescribed antimalarials is essential for effective treatment. Methods: This cross-sectional study, with in-depth telephone interviews, analyzed participants’ perceptions of short message service (SMS) in adherence to treatment. Results: Five thematic categories emerged: decreased forgetfulness, the novelty of the tool, easy-to-understand language, the impact of SMS messages during treatment, and suggestions for improvement and complaints. Conclusions: SMS could assist patients in adhering to prescribed antimalarials. Background worldwide treatment Methods crosssectional cross sectional study indepth depth interviews participants (SMS Results emerged forgetfulness tool easytounderstand easy understand language complaints Conclusions

https://doi.org/10.1590/0037-8682-0616-2022

12.

Breastfeeding mobile applications assistance in Brazil: a scoping review protocol Brazil
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Leal, Iga Carnevalli

; Gouvêa, Ester Florens Guerra

; Campos, Larissa Melgaço

; Oliveira, Ana Júlia Delfim de

; Teles, Daiana Carola de Souza

; Silva, Teresa Raquel Morais

; Barroso, Joyce Marques

; Motta, Andréa Rodrigues

; Furlan, Renata Maria Moreira Moraes

Revista CEFAC

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2023, Volume 25 N. 6 elocation e9323

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Objetivo: apresentar um protocolo de revisão de escopo destinado a identificar e analisar os aplicativos gratuitos disponíveis nos sistemas operacionais Android e iOS para o auxílio de nutrizes acerca da amamentação. Métodos: a estrutura metodológica desta revisão de escopo incluiu nove etapas: elaboração da pergunta norteadora; definição dos descritores; definição dos critérios para inclusão e exclusão de aplicativos; localização de aplicativos; listagem dos aplicativos; seleção por análise de título e ícone; levantamento dos dados dos aplicativos; seleção pela análise dos dados dos aplicativos e avaliação de qualidade. A pergunta de pesquisa foi guiada pela estratégia participantes-conceito-contexto. A localização dos aplicativos móveis para apoio ao aleitamento será realizada nas lojas Google Play Store e App Store. As etapas de seleção, levantamento dos dados e avaliação da qualidade serão realizadas por dois avaliadores independentes. A avaliação da qualidade será realizada utilizando a Mobile App Rating Scale e correlacionada com as classificações dos usuários. Considerações Finais: a presente pesquisa apresentou um protocolo de revisão de escopo destinado a identificar e analisar os aplicativos gratuitos disponíveis nos sistemas operacionais Android e iOS para o auxílio de nutrizes acerca da amamentação, pautado em nove etapas. O protocolo está pronto para ser implementado. Objetivo amamentação Métodos norteadora descritores ícone participantesconceitocontexto. participantesconceitocontexto participantes conceito contexto. contexto participantes-conceito-contexto independentes usuários Finais implementado

ABSTRACT Purpose: to present a scoping review protocol to identify and analyze free applications available for Android and iOS operating systems to assist nursing mothers in terms of breastfeeding. Methods: the methodological structure of this scoping review has nine stages: developing the research question; defining descriptors; establishing application inclusion and exclusion criteria; locating applications; listing applications; selecting them by title and icon analysis; collecting application data; selecting them by application data analysis and quality assessment. The research question was developed based on the participants-concept-context strategy. Breastfeeding mobile applications assistance will be searched in Google Play and Apple Store. Two independent raters will select applications, collect data, and assess their quality. Quality assessment will use the Mobile App Rating Scale, which will be correlated with user ratings. Final Considerations: this research presented a nine-stage scoping review protocol aimed at identifying and analyzing free applications available for Android and iOS operating systems to help nursing mothers in terms of breastfeeding. The protocol is ready to be implemented. Purpose breastfeeding Methods stages descriptors criteria participantsconceptcontext participants concept context strategy Store Scale ratings Considerations ninestage stage implemented

https://doi.org/10.1590/1982-0216/20232569323

13.

Conhecimento dos profissionais de saúde sobre cuidados paliativos: Análise de um hospital central português
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Neves, Teresa Margarida Almeida

; Marques, António Manuel

; Correia, Maria Gabriel

; Querido, Ana

; Marques, Andréa Ascenção

Revista de Enfermagem Referência

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dec 2022, Volume serVI N. 1 elocation e21041

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

Resumo Enquadramento: A evidência científica revela lacunas de conhecimento dos profissionais de saúde em cuidados paliativos, influenciando a qualidade dos cuidados. Objetivo: Caracterizar o conhecimento em cuidados paliativos dos profissionais de saúde, num hospital central universitário português. Metodologia: Estudo quantitativo, descritivo-correlacional, transversal, tendo como população-alvo os profissionais de saúde de um hospital central universitário. Aplicou-se um questionário para avaliar os conhecimentos sobre cuidados paliativos. Resultados: Dos 401 profissionais da amostra, 16,96% detém experiência e 26,18% formação específica em cuidados paliativos. Em média, identificou-se 80,53% de respostas corretas sobre filosofia dos cuidados paliativos. O conhecimento sobre controlo de sintomas e apoio à família relacionam-se negativamente com o tempo de exercício profissional (p < 0,001). Conclusão: A maioria dos profissionais demonstra conhecimento em cuidados paliativos, todavia é essencial investir na formação, particularmente nos profissionais com maior tempo de exercício profissional.

Abstract Background: Scientific evidence shows gaps in the knowledge of health professionals about palliative care, influencing the quality of care. Objective: To characterise health professionals’ knowledge about palliative care in a Portuguese central university hospital. Methodology: Quantitative, descriptive-correlational, cross-sectional study, with health professionals from a central university hospital as target population. A questionnaire was applied to assess their knowledge about palliative care. Results: Of the 401 professionals in the sample, 16.96% have experience and 26.18% specific training in palliative care. On average, 80.53% of correct answers were given regarding the philosophy of palliative care. The knowledge about symptom control and family support was negatively correlated with the length of professional experience (p < 0.001). Conclusion: Most professionals demonstrate knowledge in palliative care, however it’s essential to invest in training, particularly in professionals with more length of professional practice.

Resumen Marco contextual: La evidencia científica revela lagunas en los conocimientos de los profesionales de la salud en materia de cuidados paliativos, lo que influye en la calidad de la atención. Objetivo: Caracterizar los conocimientos sobre cuidados paliativos de los profesionales de la salud en un hospital central universitario portugués. Metodología: Estudio cuantitativo, descriptivo-correlacional, transversal, con profesionales de la salud de un hospital central universitario como población objetivo. Se aplicó un cuestionario para evaluar los conocimientos sobre cuidados paliativos. Resultados: De los 401 profesionales de la muestra, el 16,96% tenía experiencia y el 26,18% formación específica en cuidados paliativos. Por término medio, se identificó un 80,53% de respuestas correctas sobre la filosofía de los cuidados paliativos. Los conocimientos sobre el control de los síntomas y el apoyo familiar están relacionados negativamente con la duración del ejercicio profesional (p < 0,001). Conclusión: La mayoría de los profesionales demuestran tener conocimientos en cuidados paliativos, sin embargo, es fundamental invertir en formación, sobre todo para los profesionales con mayor tiempo de ejercicio profesional.

https://doi.org/10.12707/rv21041

14.

Human sporotrichosis: recommendations from the Brazilian Society of Dermatology for the clinical, diagnostic and therapeutic management
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Orofino-Costa, Rosane

; Freitas, Dayvison Francis Saraiva

; Bernardes-Engemann, Andréa Reis

; Rodrigues, Anderson Messias

; Talhari, Carolina

; Ferraz, Claudia Elise

; Veasey, John Verrinder

; Quintella, Leonardo

; Sousa, Maria Silvia Laborne Alves de

; Vettorato, Rodrigo

; Almeida-Paes, Rodrigo de

; Macedo, Priscila Marques de

Anais Brasileiros de Dermatologia

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nov 2022, Volume 97 N. 6 Pages 757 - 777

Abstract: En | Text: En | PDF: En

Abstract Background: The increase in the zoonotic epidemic of sporotrichosis caused by Sporothrix brasiliensis, which started in the late 1990s in Rio de Janeiro and is now found in almost all Brazilian states, has been equally advancing in neighboring countries of Brazil. Changes in the clinical-epidemiological profile, advances in the laboratory diagnosis of the disease, and therapeutic difficulties have been observed throughout these almost 25 years of the epidemic, although there is no national consensus. The last international guideline dates from 2007. Objectives: Update the clinical classification, diagnostic methods and recommendations on the therapeutic management of patients with sporotrichosis. Methods: Twelve experts in human sporotrichosis were selected from different Brazilian regions, and divided into three work groups: clinical, diagnosis and treatment. The bibliographic research was carried out on the EBSCOHost platform. Meetings took place via electronic mail and remote/face-to-face and hybrid settings, resulting in a questionnaire which pointed out 13 divergences, resolved based on the opinion of the majority of the participants. Results: The clinical classification and laboratory diagnosis were updated. Therapeutic recommendations were made for the different clinical forms. Conclusions: Publication of the first national recommendation, carried out by the Brazilian Society of Dermatology, aimed at the Brazilian scientific community, especially dermatologists, infectologists, pediatricians, family medicine personnel, and laboratory professionals who work in the management of human sporotrichosis.

https://doi.org/10.1016/j.abd.2022.07.001

15.

Posicionamento sobre a Saúde Cardiovascular nas Mulheres – 2022
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Oliveira, Glaucia Maria Moraes de

; Almeida, Maria Cristina Costa de

; Marques-Santos, Celi

; Costa, Maria Elizabeth Navegantes Caetano

; Carvalho, Regina Coeli Marques de

; Freire, Cláudia Maria Vilas

; Magalhães, Lucelia Batista Neves Cunha

; Hajjar, Ludhmila Abrahão

; Rivera, Maria Alayde Mendonça

; Castro, Marildes Luiza de

; Avila, Walkiria Samuel

; Lucena, Alexandre Jorge Gomes de

; Brandão, Andréa Araujo

; Macedo, Ariane Vieira Scarlatelli

; Lantieri, Carla Janice Baister

; Polanczyk, Carisi Anne

; Albuquerque, Carlos Japhet da Matta

; Born, Daniel

; Falcheto, Eduardo Belisário

; Bragança, Érika Olivier Vilela

; Braga, Fabiana Goulart Marcondes

; Colombo, Fernanda M. Consolim

; Jatene, Ieda Biscegli

; Costa, Isabela Bispo Santos da Silva

; Rivera, Ivan Romero

; Scholz, Jaqueline Ribeiro

; Melo Filho, José Xavier de

; Santos, Magaly Arrais dos

; Izar, Maria Cristina de Oliveira

; Azevedo, Maria Fátima

; Moura, Maria Sanali

; Campos, Milena dos Santos Barros

; Souza, Olga Ferreira de

; Medeiros, Orlando Otávio de

; Silva, Sheyla Cristina Tonheiro Ferro da

; Rizk, Stéphanie Itala

; Rodrigues, Thais de Carvalho Vieira

; Salim, Thaís Rocha

; Lemke, Viviana de Mello Guzzo

Arquivos Brasileiros de Cardiologia

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nov 2022, Volume 119 N. 5 Pages 815 - 882

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

https://doi.org/10.36660/abc.20220734

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