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Total mercury in wild felids occurring in protected areas in the central Brazilian Amazon
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LOPES, Marcelly Castello Branco

; CARVALHO, Gabriel Oliveira de

; BERNARDO, Robson Roney

; MACEDO, Joana

; LINO, Adan Santos

; RAMALHO, Emiliano Esterci

; KASPER, Daniele

; MEIRE, Rodrigo Ornellas

; TORRES, João Paulo Machado

; MALM, Olaf

Acta Amazonica

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jun 2020, Volume 50 N. 2 Pages 142 - 148

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Este é o primeiro estudo a investigar a contaminação por mercúrio (Hg) em espécies de felinos na Amazônia brasileira. Foram coletadas 26 amostras de pelo de felinos selvagens de quatro espécies (Puma concolor, Panthera onca, Leopardus pardalis e Leopardus wiedii) ocorrendo nas reservas de desenvolvimento sustentável Mamirauá e Amanã, no estado do Amazonas. As amostras foram coletadas de espécimes de museu, exceto cinco amostras de P. onca obtidas de indivíduos capturados em vida livre. As concentrações de Hg variaram de 0,12 a 48,1 µg g-1. Não houve diferença significativa entre a concentração de Hg no pelo de espécimes de museu e de indivíduos vivos de P. onca. Houve variação significativa entre espécies, sendo que P. onca e L. pardalis tiveram concentrações significativamente mais altas, o que pode estar relacionado a fatores como dieta e hábitat.

ABSTRACT This is the first study to investigate mercury (Hg) contamination in felid species in the Brazilian Amazon. We collected 26 fur samples from wild felids of four species (Puma concolor, Panthera onca, Leopardus pardalis and Leopardus wiedii) occurring in the Mamirauá and Amanã sustainable development reserves, in the state of Amazonas. Samples were from museum specimens, except for five P. onca samples collected from free-living individuals. Total Hg concentrations ranged from 0.12 to 48.1 µg g-1. Concentrations of Hg did not differ significantly between museum specimens and live individuals of P. onca, but varied significantly among species, with significantly higher concentrations for P. onca and L. pardalis, which could be related to factors such as diet and habitat.

https://doi.org/10.1590/1809-4392201903331 1325 downloads

Diagnostic accuracy of 18F-FDG-PET in abdominal sepsis in rats
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Azevedo, Ítalo Medeiros

; Macedo Filho, Robson

; Rocha, Keyla Borges Ferreira

; Oliveira, Cláudia Nunes

; Medeiros, Aldo Cunha

Acta Cirúrgica Brasileira

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2020, Volume 35 N. 5 elocation e202000505

Abstract: En | Text: En | PDF: En

Abstract Purpose The objective of this study was to investigate the accuracy of 18F-FDG-PET in the diagnosis of multibacterial abdominal sepsis by cecum ligation and puncture (CLP) in rats. Methods Adult Wistar rats ( Rattus norvegicus ), weighing 227±35g, were allocated into a sepsis group by CLP (n=10) and sham group (n=10). 18F-FDG-PET using microPET was performed on all rats after 24 hours. Results All animals survived for postoperative 24h. The abdomen/liver ratio of the standardized uptake value (SUV) percentage was significantly higher in the sepsis group than in the sham (p=0.004). The ROC curve showed an accuracy of 18F-FDG-PET to detect abdominal sepsis of 88.9% (p=0.001), sensitivity of 90% and specificity of 88.9%. When a cut-off point of 79% of the ratio between the SUV on the abdominal region and liver was established, the sensitivity was 90%, specificity of 88.9%; positive and negative predictive values of 90.0% and 88.9%, respectively. Conclusions The diagnostic accuracy of 18F-FDG-PET in rats with abdominal sepsis was significantly high. It was also demonstrated the predictive ability of the abdomen/liver SUV ratio to diagnose abdominal sepsis. These findings may have implications for the clinical setting, locating septic foci with PETscan.

https://doi.org/10.1590/s0102-865020200050000005 579 downloads

Effect of Arrabidaea chica extract against chemically induced breast cancer in animal model
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Rocha, Keyla Borges Ferreira

; Oliveira, Cláudia Nunes

; Azevedo, Ítalo Medeiros

; Macedo, Robson de

; Medeiros, Aldo Cunha

Acta Cirúrgica Brasileira

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oct 2019, Volume 34 N. 10 elocation e201901001

Abstract: En | Text: En | PDF: En

Abstract Purpose: To examine the effects of Arrabidaa chica (Bignoniacea) extract, a native plant of the Amazon known as crajiru, on a 7,12-dimethyl-1,2-benzanthracene (DMBA)-induced breast cancer model in Wistar rats. Methods: We compared the response of breast cancer to the oral administration of A. chica extract (ACE) for 16 weeks, associated or not with vincristine. Groups: normal control; DMBA (50mg/kg v.o,) without treatment; DMBA+ACE (300 mg/kg); DMBA+vincristine. 500μg/kg injected i.p; DMBA+ACE+Vincristine 250μg/kg i.p. Imaging by microPET and fluorescence, biochemistry, oxidative stress, hematology and histopathology were used to validate the treatments. Results: All animals survived. A gradual weight gain in all groups was observed, with no significant difference (p>0.05). The oral administration of ACE and ACE+vincristine 50% significantly reduced breast tumors incidence examined with PET-18FDG and fluorescence (p<0.001). Significant reduction of serum transaminases, oxidative stress and hematological toxicity were observed in these groups. Antioxidant enzyme levels in breast tissue were significantly higher compared to the DMBA and DMBA+vincristine groups. Conclusion: These results demonstrate for the first time that ACE positively influences the treatment of DMBA-induced breast cancer in animal model, inducing a reduction in oxidative stress and chemotherapy toxicity, meaning that ACE may have clinical implication in further studies.

https://doi.org/10.1590/s0102-865020190100000001 1258 downloads

Effect of the addition of protected fat from palm oil to the diet of dairy sheep
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Bianchi, Anderson Elias

; Macedo, Vicente de Paulo

; Silva, Aleksandro Schafer Da

; Silveira, André Luís Finkler da

; Hill, João Ari Gualberto

; Zortéa, Talyta

; Rossi, Robson Marcelo

; Batista, Rafael

Revista Brasileira de Zootecnia

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2018, Volume 47 elocation e20160137

Abstract: En | Text: En | PDF: En

ABSTRACT The objective of this study was to evaluate the effect of protected fat from palm oil on body weight and milk production and composition of lactating Lacaune ewes. Four treatments (0, 20, 40, and 60 g kg−1 as fed) of protected fat from palm oil were used to feed nine animals in each group. Isoproteic and isoenergetic diets were formulated and adjusted for each animal after milk weighing. Corn silage was used as roughage on the same proportion of concentrated to feed all animals. Milk samples were collected weekly for chemical analyses up to the seventh week of the lactation period and every other week after that until the end of the lactation period (182 days). Increased levels of protected fat in the diet of lactating ewes resulted in lower body weight gain and poor animal body condition. The production peak showed differences and was higher in the treatment of 40 g kg−1 of palm oil, but milk production during lactation was higher in animals that received 60 g kg−1 of protected fat supplementation. Animals fed 60 g kg−1 of protected fat showed the highest milk yield. We observed a positive linear effect on milk fat content, whereas the effect on milk protein, lactose, and nonfat solids was linearly negative after dairy sheep fed protected fat from palm oil. There were no changes in the amount (kg) of milk fat, protein, lactose, total solids, and nonfat solids in any of the treatments. Therefore, protected fat from palm oil is efficient to increase milk production and fat content.

https://doi.org/10.1590/rbz4720160137 1148 downloads

Anatomo-radiological correlation using 18-FDG-PET in abdominal sepsis model in rats. A preliminary study
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Azevedo, Ítalo Medeiros

; Carvalho, Marília Daniela Ferreira

; Nascimento, Rafael Pereira

; Macedo, Robson

; Aquino, Mônica Raquel de Souza

; Medeiros, Aldo Cunha

Acta Cirúrgica Brasileira

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mar 2017, Volume 32 N. 3 Pages 175 - 181

Abstract: En | Text: En | PDF: En

Abstract Purpose: To examine a correlation of micro-PET images with photographic images of the digestive organs in abdominal sepsis model. Methods: Male Wistar rats weighing 265±18g were used. Abdominal sepsis was induced by ligature and cecal puncture. Micro-PET Images from abdominal cavity septic foci were obtained using 18-Fluoro-deoxyglucose, looking for a correlation with photographic images of abdominal cavity organs. Pearson's correlation test was used. Results: The mean standard uptake values (SUV) and lesion areas were 2.58±0.63SUVbwg/ml and 546.87±300.95mm2, respectively. There was a strong positive correlation between the two variables (r=0.863, p=0.137), which resulted in a coefficient of determination r2?0.75, meaning that 75% of SUV variation is explained by the lesion areas of digestive organs. Conclusion: Micro-PET allows high throughput assessment of lesion count and volume in pre-clinical rat model of CPL abdominal sepsis.

https://doi.org/10.1590/s0102-865020170030000001 1218 downloads

Conhecimento pedagógico do conteúdo de “estrutura da matéria” de uma professora de química experiente em aulas de química geral
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Leal, Sérgio Henrique

; Novais, Robson Macedo

; Fernandez, Carmen

Ciência & Educação (Bauru)

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sep 2015, Volume 21 N. 3 Pages 725 - 742

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo:Nesse trabalho investigamos o Conhecimento Pedagógico do Conteúdo de uma professora de Química experiente, do nível Superior de ensino, com histórico de bom desempenho. Um estudo de caso qualitativo foi desenvolvido a partir: do registro audiovisual de suas aulas, aplicação do instrumento Representação do Conteúdo (CoRe), realização de entrevistas semiestruturadas, e reflexão estimulada. Observamos que a professora consegue mobilizar, em sua prática, a maioria das categorias do Conhecimento Pedagógico do Conteúdo (PCK), adotando a “Didática” como orientação para o ensino de ciências e demonstrando grande preocupação com a transmissão dos fatos científicos. Apesar de suas aulas serem predominantemente expositivas e centradas na figura do professor, foi possível identificar momentos de abordagem interativa, na qual considera os diferentes pontos de vista dos alunos sobre o conteúdo ministrado. Finalmente, constatamos que a professora apresenta uma prática pedagógica refletida, sobretudo no que se refere às suas estratégias de ensino.

Abstract:In this paper we investigate the Pedagogical Content Knowledge (PCK) of an experienced teacher of Chemistry higher level of education with a history of good performance. A qualitative case study was developed from the audiovisual record of their lessons, instrument application of Content Representation (CoRe), semi-structured interviews and stimulated reflection. We note that the teacher can mobilize in their practice most categories of PCK, adopting the “Didactic” as an orientation for teaching science and showing great concern for the transmission of scientific facts. Despite their classes being predominantly lectures and teacher centered, it was possible to identify moments of an interactive approach, which considers the different views of students on the content taught. Finally, we note that the teacher presents a pedagogical practice that reflected in their teaching strategies.

https://doi.org/10.1590/1516-731320150030013 5790 downloads

Heart and systemic effects of statin pretreatment in a rat model of abdominal sepsis. Assessment by Tc99m-sestamibi biodistribition
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Macedo, Robson

; Javadi, Som Mehrbod

; Higuchi, Takahiro

; Carvalho, Marília Daniela Ferreira de

; Medeiros, Vanessa de Fátima Lima Paiva

; Azevedo, Ítalo Medeiros

; Lima, Francisco Pignataro

; Medeiros, Aldo Cunha

Acta Cirúrgica Brasileira

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jun 2015, Volume 30 N. 6 Pages 388 - 393

Abstract: En | Text: En | PDF: En

PURPOSE:To evaluate the heart and the Tc-99m-sestamibi biodistribution after statin pretreatment in a rat model of abdominal sepsis.METHODS:Twenty-four Wistar rats were randomly distributed into four groups (n=6 per group): 1) sepsis with simvastatin treatment, 2) sepsis with vehicle, 3) sham control with simvastatin and 4) sham control with vehicle. 24 hours after cecal ligation and puncture rats received 1.0MBq of Tc-99m-sestamibi i.v. 30min after, animals were euthanized for ex-vivo tissue counting and myocardium histological analysis.RESULTS: Myocardial histologic alterations were not detected 24 hours post-sepsis. There was significantly increased cardiac Tc-99m-sestamibi activity in the sepsis group with simvastatin treatment (1.9±0.3%ID/g, p<0.001) in comparison to the sepsis group+vehicle (1.0±0.2%ID/g), control sham group+ simvastatin (1.2±0.3%ID/g) and control sham group (1.3±0.2%ID/g). Significant Tc-99m-sestamibi activity in liver, kidney and lungs was also detected in the sepsis group treated with simvastatinin comparison to the other groups.CONCLUSIONS:Statin treatment altered the biodistribution of Tc-99m-sestamibi with increased cardiac and solid organ activity in rats with abdominal sepsis, while no impact on controls. Increased myocardial tracer activity may be a result of a possible protection effect due to increased tissue perfusion mediated by statins.

https://doi.org/10.1590/S0102-865020150060000003 1701 downloads

II Diretriz de Ressonância Magnética e Tomografia Computadorizada Cardiovascular da Sociedade Brasileira de Cardiologia e do Colégio Brasileiro de Radiologia
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Sara, Leonardo

; Szarf, Gilberto

; Tachibana, Adriano

; Shiozaki, Afonso Akio

; Villa, Alexandre Volney

; Oliveira, Amarino Carvalho de

; Albuquerque, Andrei Skromov de

; Rochitte, Carlos Eduardo

; Nomura, César Higa

; Azevedo, Clerio Francisco

; Jasinowodolinski, Dany

; Tassi, Eduardo Marinho

; Medeiros, Fabio de Morais

; Kay, Fernando Uliana

; Junqueira, Flávia Pegado

; Azevedo, Guilherme S. A.

; Monte, Guilherme Urpia

; Pinto, Ibraim Masciarelli Francisco

; Gottlieb, Ilan

; Andrade, Joalbo

; Lima, João A. C.

; Parga Filho, José Rodrigues

; Kelendjian, Juliana

; Fernandes, Juliano Lara

; Iquizli, Leonardo

; Correia, Luis C. L.

; Quaglia, Luiz Augusto

; Gonçalves, Luiz Flavio Galvão

; Ávila, Luiz Francisco

; Zapparoli, Marcello

; Hadlich, Marcelo

; Nacif, Marcelo Souto

; Barbosa, Márcia de Melo

; Minami, Márcio Hiroshi

; Bittencourt, Marcio Sommer

; Siqueira, Maria Helena Albernaz

; Silva, Marly Conceição

; Lopes, Marly Maria Uellendahl

; Marques, Mateus Diniz

; Vieira, Mônica La Rocca

; Coellho Filho, Otávio Rizzi

; Schvartzman, Paulo R.

; Santos, Raul D.

; Cury, Ricardo C.

; Loureiro, Ricardo

; Cury, Roberto Caldeira

; Sasdelli Neto, Roberto

; Macedo, Robson

; Cerci, Rodrigo Julio

; Faria Filho, Rui Alberto de

; Cardoso, Sávio

; Naves, Thiago

; Magalhães, Tiago Augusto

; Senra, Tiago

; Burgos, Ursula Maria Moreira Costa

; Moreira, Valéria de Melo

; Ishikawa, Walther Yoshiharu

Arquivos Brasileiros de Cardiologia

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dec 2014, Volume 103 N. 6 Pages 1 - 86

Abstract: Pt | Text: Pt | PDF: Pt

https://doi.org/10.5935/abc.2014S006 67586 downloads

Medidas morfofuncionais do coração obtidas por ressonância magnética em brasileiros
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Macedo, Robson

; Fernandes, Juliano Lara

; Andrade, Solange Souza

; Rochitte, Carlos Eduardo

; Lima, Kênio Costa

; Maciel, Álvaro Campos Cavalcanti

; Maciel, Fernanda Cunha

; Alves, Geraldo Souza Pinho

; Coelho, Otávio Rizzi

; Diniz, Rosiane Viana Zuza

Arquivos Brasileiros de Cardiologia

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jul 2013, Volume 101 N. 1 Pages 68 - 77

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

FUNDAMENTO: Medidas ainda hoje utilizadas como referência na ressonância magnética cardíaca foram obtidas principalmente de estudos realizados em populações norte-americanas e europeias. OBJETIVO: Obter medidas do diâmetro diastólico, diâmetro sistólico, volume diastólico final, volume sistólico final, fração de ejeção e massa miocárdica dos ventrículos esquerdo e direito em brasileiros. MÉTODOS: Foram submetidos à ressonância magnética cardíaca, utilizando técnica de precessão livre em estado de equilíbrio, 54 homens e 53 mulheres, com idade média de 43,4 ± 13,1 anos, assintomáticos, sem cardiopatias. RESULTADOS: As médias e os desvios padrão dos parâmetros do ventrículo esquerdo foram: diâmetro diastólico = 4,8 ± 0,5 cm; diâmetro sistólico = 3,0 ± 0,6 cm; volume diastólico final = 128,4 ± 29,6 mL; volume sistólico final = 45,2 ± 16,6 mL; fração de ejeção = 65,5 ± 6,3%; massa = 95,2 ± 30,8 g. Para o ventrículo direito, foram: diâmetro diastólico = 3,9 ± 1,3 cm; diâmetro sistólico = 2,5 ± 0,5 cm; volume diastólico final = 126,5 ± 30,7 mL; volume sistólico final = 53,6 ± 18,4 mL; fração de ejeção = 58,3 ± 8,0% e massa = 26,1 ± 6,1 g. As massas e os volumes foram significativamente maiores nos homens, exceto para o volume sistólico final do ventrículo esquerdo. A fração de ejeção do ventrículo direito foi significativamente maior nas mulheres. Houve correlação significativa e inversa do volume sistólico do volume direito com o aumento da idade. CONCLUSÃO: Este estudo descreveu, pela primeira vez, medidas cardíacas obtidas pela ressonância magnética cardíaca em brasileiros assintomáticos, sem cardiopatias, mostrando diferenças de acordo com o gênero e a idade.

BACKGROUND: Still today, measurements used as a reference in the cardiac magnetic resonance imaging have been obtained mainly from studies carried out in North-American and European populations. OBJECTIVE: To obtain measurements of the diastolic diameter, systolic diameter, end diastolic volume, end systolic volume, ejection fraction, and myocardial mass of the left and right ventricles in Brazilians. METHODS: 54 men and 53 women, with mean age of 43.4 ± 13.1 years, asymptomatic, with no cardiomyopathies, have been subjected to the cardiac magnetic resonance imaging, using a balanced steady state free precession technique. RESULTS: The averages and the standard deviations of the parameters for the left ventricle have been: diastolic diameter = 4.8 ± 0.5 cm; systolic diameter = 3.0 ± 0.6 cm; end diastolic volume = 128.4 ± 29.6 mL; end systolic volume = 45.2 ± 16.6 mL; ejection fraction = 65.5 ± 6.3%; mass = 95.2 ± 30.8 g. For the right ventricle, they have been: diastolic diameter = 3.9 ± 1.3 cm; systolic diameter = 2.5 ± 0.5 cm; end diastolic volume = 126.5 ± 30.7 mL; end systolic volume = 53.6 ± 18.4 mL; ejection fraction = 58.3 ± 8.0%, and mass = 26.1 ± 6.1 g. The masses and the volumes were significantly greater in the men, except for the end systolic volume of the left ventricle. The ejection fraction of the right ventricle has been significantly greater in the women. There has been a significant and inverted correlation of the systolic volume of the right volume with the progression of the age. CONCLUSION: This study has described, for the first time, cardiac measurements obtained through the cardiac magnetic resonance imaging in Brazilians, asymptomatic, with no cardiomyopathies, showing differences in accordance with gender and age.

https://doi.org/10.5935/abc.20130113 6411 downloads

10.

Performance and carcass characteristics of lambs fed on diets supplemented with glycerin from biodiesel production
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Gomes, Marco Antonio Bensimon

; Moraes, Gentil Vanini de

; Mataveli, Marcela

; Macedo, Francisco de Assis Fonseca de

; Carneiro, Thais Cristina

; Rossi, Robson Marcelo

Revista Brasileira de Zootecnia

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oct 2011, Volume 40 N. 10 Pages 2211 - 2219

Abstract: En | Text: En | PDF: En

This study was carried out to evaluate the influence of diets supplemented with glycerin as an alternative ingredient to corn on the performance and carcass characteristics of Santa Inês confined lambs. The study involved 27 lambs aged 90 days, having an average initial weight of 26.33 ± 0.15 kg. Lambs were randomly distributed into a control group and groups with diets containing 15 and 30% glycerin in the total feed. Diet was formulated with 40% roughage and 60% concentrate. The experimental design was completely randomized, and the production performance and carcass characteristics were analyzed by analysis of variance, and the subjective carcass characteristics, by general linear models. The daily average gain was 0.21, 0.24 and 0.23 kg/day; feeding conversion was 6.39, 5.73 and 5.92 kg of diet/kg BW for control animals, and those fed with 15 or 30% glycerin, respectively, without treatment differences. Lambs were slaughtered, weighing 34 to 36 kg, and average weight of the cold carcass and commercial carcass yield were evaluated. The results were, respectively, 15.97 kg and 49.18%, for control, 15.96 kg and 48.31% for animals fed with 15% glycerin, and 15.79 kg and 47.87% for those treated with 30% glycerin, with no treatment effects. Meat tenderness and cooking loss averages were not affected by diets, with 5.07 kg and 40.45%, 5.10 kg and 40.81%, and 5.27 kg and 39.04%, respectively, for control, and those fed with 15 or 30% glycerin. Therefore, it is possible to conclude that up to 30% of medium purity glycerin in the dry matter of the diet can be used to replace corn, without any negative effect on lamb performance or carcass characteristics.

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11.

Fístula coronariana para ventrículo esquerdo: diagnóstico por tomografia computadorizada
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Mendonça, Roberto Moreno

; Bandeira, Rodrigo Lima

; Fonseca, Fredson J. S

; Macedo Filho, Robson

Arquivos Brasileiros de Cardiologia

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oct 2011, Volume 97 N. 4 Pages e82 - e85

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

Fístulas de artérias coronárias são raras, sendo diagnosticadas mais frequentemente pelo ecocardiograma ou pela cineangiocoronariografia, entretanto, a angiotomografia computadorizada (angio-TC) das coronárias ganha espaço. Essa patologia apresenta incidência baixíssima, sendo as fístulas originadas da coronária direita mais frequentes. Fístulas coronarianas para câmaras cardíacas direitas são mais incidentes, sendo raras para o ventrículo esquerdo (VE). O tratamento pode ser cirúrgico ou percutâneo. Este relato descreve caso de fístula coronariana para VE diagnosticada pela angio-TC das coronárias em homem de 46 anos, hipertenso, assintomático com teste ergométrico positivo para isquemia. Angio-TC de coronárias descartou doença obstrutiva, porém revelou fístula coronariana conectando-se com cavidade ventricular esquerda.

Coronary artery fistulas are rare and are most often diagnosed by echocardiography or by cine-angiocardiography. However, the computed tomography angiography (CTA) of coronary arteries has been gaining ground. The incidence of this disease is very low, with a more frequent occurrence of fistulas originating in the right coronary artery. There is a higher incidence of coronary artery fistulas to right heart chambers, with coronary artery fistulas to the left ventricle (LV) being rare. Treatment can be surgical or percutaneous. This report describes a case of coronary fistula to left ventricle diagnosed by CT angiography of coronary arteries in a hypertensive and asymptomatic 46-year-old male, who was tested positive for ischemia in an exercise test. The CT angiography ruled out coronary obstructive disease, but it revealed a coronary fistula to the left ventricular cavity.

Fístulas de arterias coronarias son raras, siendo diagnosticadas más frecuentemente por el ecocardiograma o por la cineangiocoronariografía, entre tanto, la angiotomografía computarizada (angio-TC) de las coronarias gana espacio. Esa patología presenta incidencia bajísima, siendo las fístulas originadas de la coronaria derecha más frecuentes. Fístulas coronarias para cámaras cardíacas derechas son más incidentes, siendo raras para el ventrículo izquierdo (VI). El tratamiento puede ser quirúrgico o percutáneo. Este relato describe caso de fístula coronaria para VI diagnosticada por la angio-TC de las coronarias en hombre de 46 años, hipertenso, asintomático con test ergométrico positivo para isquemia. Angio-TC de coronarias descartó enfermedad obstructiva, sin embargo reveló fístula coronaria conectándose con cavidad ventricular izquierda.

10171 downloads

12.

Estudo do autorrelato de adesão e uso problemático de álcool em uma população de indivíduos com AIDS em uso de HAART
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Rego, Samuel Robson Moreira

; Oliveira, Carlos Francisco Almeida de

; Rego, Daianny Macedo de Sousa

; Santos Júnior, Raimundo Félix dos

; Silva, Vitor Brito da

Jornal Brasileiro de Psiquiatria

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2011, Volume 60 N. 1 Pages 46 - 49

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

OBJETIVO: O objetivo deste estudo foi analisar a força de associação entre as variáveis autorrelato de adesão à medicação e uso problemático de álcool em uma população de indivíduos com AIDS que fazem uso de HAART. MÉTODO: Foram entrevistados 103 pacientes com AIDS, em uso de HAART há pelo menos seis meses, que frequentavam o ambulatório do Instituto de Doenças Tropicais Natan Portela (IDTNP), localizado na cidade de Teresina, PI. A variável independente estudada foi o uso problemático de álcool, além de variáveis sociodemográficas. O questionário utilizado para avaliar o uso problemático de álcool foi o AUDIT (Alcohol Use Disorders Identification Test). A variável dependente avaliada neste estudo foi o autorrelato de adesão ao tratamento para o HIV. Para sua mensuração, optou-se por utilizar o QSAM (Questionário Simplificado de Adesão à Medicação), por tratar-se de um questionário bastante simples e de fácil aplicação. RESULTADOS: A frequência de AUDIT > 08 foi de 33%; já o autorrelato de adesão, avaliado pelo QSAM, foi positivo em 45% da amostra. Testada a associação entre a frequência de QSAM positivo e o AUDIT positivo, encontrou-se forte associação entre essas variáveis (p = 0,004). CONCLUSÃO: Conclui-se deste estudo que o autorrelato de falha na adesão ao HAART aferido por meio do QSAM é um fator de risco para a presença de uso problemático de álcool.

OBJECTIVE: The aim of this study was to analyze the strength of association between the variables self-report of adherence to medication and problematic use of alcohol in a population of individuals with AIDS making use of HAART. METHOD: 103 patients with AIDS, using HAART for at least six months and which visited the infirmary of the Natan Portela Institute for Tropical Diseases (DNPITD), located in the city of Teresina-PI, were interviewed. The independent variable studied was problematic use of alcohol, and sociodemographical variables. The questionnaire used to evaluate the problematic use of alcohol was the AUDIT (Alcohol Use Disorders Identification Test). The dependent variable evaluated in this study was the self-report of adherence to HIV treatment. For its measurement we chose to use the SQAM (Simplified Questionnaire of Adherence to Medication), for its simplicity and ease of application. RESULTS: The frequency of AUDIT > 08 was of 33%. The self-report of adherence, evaluated by the SQAM, was positive in 45% of the sample. Once tested the association between the frequency of positive SQAM and the positive AUDIT, a strong association was found between those variables (p = 0,004). CONCLUSION: We conclude from this study that the self-report of failure of adherence to HAART, gathered by the SQAM is a risk factor to the presence of problematic use of alcohol.

3266 downloads

13.

Zoneamento de risco climático para a cultura do café Conilon no Estado do Espírito Santo
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Pezzopane, José Ricardo Macedo

; Castro, Fábio da Silveira

; Pezzopane, José Eduardo Macedo

; Bonomo, Robson

; Saraiva, Giselle Sabadim

Revista Ciência Agronômica

Journal Metrics
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sep 2010, Volume 41 N. 3 Pages 341 - 348

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

O presente trabalho teve por objetivo apresentar um zoneamento de risco climático, baseado no atendimento hídrico para o café Conilon para o estado do Espírito Santo, em função da variação das necessidades de água nas fases fenológicas do florescimento, granação dos frutos e crescimento vegetativo. Foi realizada para cada fase fenológica uma análise frequencial da evapotranspiração relativa, obtida pela relação entre as evapotranspirações real e de referência, provenientes de um modelo de balanço hídrico sequencial. Posteriormente procedeu-se a espacialização de riscos climáticos de atendimento hídrico para o café Conilon considerando simultaneamente as fases fenológicas da floração, granação e crescimento vegetativo. Os resultados indicaram que devido à característica heterogênea do regime pluviométrico, associada às diferentes demandas hídricas, ocorre uma variação espacial do risco climático ao atendimento hídrico no Estado e que a partir da análise simultânea de atendimento hídrico nas diferentes fases fenológicas do café Conilon, identificou-se que 58% da área do Espírito Santo, concentrada principalmente na região norte, apresenta alto risco climático nas fases vegetativa do florescimento, granação e crescimento vegetativo.

A frequencial analysis of the crop water requirement index of the Conilon coffee (Coffea canephora), determined for the occurrence of relative evapotranspiration (ETr/ETo) > 0.65 above 80% of the years, was carried through for the phenological stages of the flowering, bean formation and vegetative growth. The areas with climatic risk of water deficit were zoned by a geographic information system considering simultaneously the three phenological stages. The results showed that due to heterogeneous rain characteristics, associate to the different water requirements, occurs a space variation of the climatic risk to the water required in the State. In analysis of water required in the different phonological stages of the Conilon coffee, it was identified that 58% of the area of the state of Espirito Santo, mainly in the north part, presents high climatic risk of water required in the phases of the flowering, bean formation and vegetative growth.

5645 downloads Cited 8 times in SciELO

14.

Toxicidade aguda dos extratos hidroalcoólicos das folhas de alecrim-pimenta, aroeira e barbatimão e do farelo da casca de pequi administrados por via intraperitoneal
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Almeida, Anna Christina

; Sobrinho, Eliane Macedo

; Pinho, Lucineia de

; Souza, Patrícia Nery Silva

; Martins, Ernane Ronie

; Duarte, Eduardo Robson

; Santos, Hércules Otacílio

; Brandi, Igor Viana

; Cangussu, Alex Sander

; Costa, João Paulo Ramos

Ciência Rural

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feb 2010, Volume 40 N. 1 Pages 200 - 203

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

O estudo objetivou realizar ensaio toxicológico pré-clínico inicial para investigar a toxicidade das folhas de alecrim-pimenta (Lippia sidoides Cham.), aroeira (Myracrodruon urundeuva Fr. All.) e barbatimão [Stryphnodendron adstringens (Mart.) Coville] e do farelo da casca de pequi (Caryocar brasiliense Camb.), por meio da determinação da dose letal 50% (DL50). Na investigação da DL50, foram utilizados grupos de camundongos Swiss de mesmo sexo (n=150, sendo 30 animais por tratamento) inoculados, por via intraperitoneal, com diluições seriadas do extrato hidroalcoólico das folhas de alecrim, aroeira e barbatimão e do farelo da casca de pequi. Após a inoculação, os animais foram observados por um período de 14 dias, para determinar a quantidade de mortos, doentes e sobreviventes. O estudo toxicológico pré-clínico agudo demonstrou, em camundongos por via intraperitoneal, toxicidade igual a 0,31mg mL-1 DL50 mL-1 para todas as plantas, exceto para o barbatimão, que apresentou toxicidade igual a 0,25mg mL-1. Pesquisas devem ser realizadas visando a obter dados de toxicidade das plantas em outras vias para assegurar o uso em saúde humana e animal.

This study aimed to conductpre-clinical toxicology testing to investigate the toxicity of Lippia sidoides Cham., Myracrodruon urundeuva Fr. All., Stryphnodendron adstringens (Mart.) Coville and Caryocar brasiliense Camb., by determining the 50% (LDL50) lethal dose. In the investigation of the LD50, groups of Swiss mice of the same sex were used (n=150; 30 animals per plant and all inoculated intraperitoneally with serial dilutions of the aqueous fraction obtained from the leaves of plants. After inoculation, the animals were observed along a period of 14 days in order to observe the dead, sick and survivors rate. In mice inoculated intraperitoneally, the acute pre-clinical toxicology testing demonstrated toxicity equal to 0,31mg mL-1 LD50 mL-1 for all plants. The exception was for Stryphnodendron adstringens, which presented toxicity equal to a 0,25mg mL-1DL50 mL-1 and values expressed in terms of dilution. Research should be conducted to obtain data on toxicity of the plants in other ways to ensure the use in human and animal health. Therefore, the studied plants should be used with caution. They present a relatively mild toxic potential, but it may be harmful to users if they are not properly utilized.

9695 downloads Cited 2 times in SciELO

15.

Associação entre uso de álcool em indivíduos com AIDS e adesão ao tratamento antirretroviral: uma revisão da literatura
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Rego, Samuel Robson Moreira

; Rego, Daianny Macedo de Sousa

Jornal Brasileiro de Psiquiatria

Journal Metrics
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2010, Volume 59 N. 1 Pages 70 - 73

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

OBJETIVO: O objetivo deste trabalho foi fazer uma revisão sistemática da literatura, utilizando a base de dados MedLine, sobre o tema: uso/abuso/dependência de álcool como um fator de risco à redução da adesão, à redução na supressão da carga viral ou ao pior desfecho clínico em pacientes com AIDS em uso de highly active antiretroviral therapy (HAART). MÉTODO: Foi realizada uma pesquisa sistemática na base de dados MedLine utilizando como unitermos "HAART", "adherence" e "alcohol", na busca de artigos que versassem sobre a temática: avaliação ou associação de uso/abuso/dependência de álcool e adesão/supressão da carga viral/ desfecho clínico nos pacientes em uso de terapia antirretroviral. RESULTADOS: A busca resultou em 65 artigos. Contudo, apenas 21 deles contemplaram os critérios de inclusão e foram selecionados. Foi encontrada associação positiva entre uso/abuso/dependência de álcool e baixa adesão/baixa supressão da carga viral/pior desfecho clínico em 18 (85,7%) artigos. CONCLUSÃO: O uso/abuso/dependência de álcool é um fator de risco para baixa adesão/baixa supressão da carga viral/pior desfecho clínico nos indivíduos em uso de HAART.

OBJECTIVE: The purpose of this work was to make a systematic review of the literature, using the MedLine data basis, about the alcohol usage/abuse/dependence as a risk factor to the adherence reduction, the viral load reduction or even a worse clinical outcome in HIV patients in the usage of highly active antiretroviral therapy (HAART). METHOD: It was made a systematic research in the MedLine data basis using the words: "HAART", "adherence" and "alcohol" with the purpose of finding articles about the themes: evaluations or association between the alcohol usage/abuse/dependence and adherence/suppression of the viral load/clinical outcome in HIV patients in the usage of antiretroviral therapy. RESULTS: The search found 65 articles. However, only 21 of this achieved the pre-established criteria and have been selected. It was found a positive association among the usage/abuse/dependence of the alcohol and the low adherence/low viral load suppression/worse clinical outcome in 18 (85,7%) of the articles. CONCLUSION: We could conclude that the alcohol usage/abuse/dependence is a risk factor to the low adherence/low viral load suppression/worse clinical outcome in HIV patients in the usage of HAART.

4986 downloads Cited 2 times in SciELO

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