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1.
Computer-Aided Drug Design Studies in Association with in vitro Antileishmanial Tests for New Chalcones ComputerAided Computer Aided
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Silva, Gleice R. da
; Santos, Francisnaira S.
; Leite, Fernando F.
; Acevedo, Chonny A. H.
; Sousa, Natália F. de
; Grimaldi, Gabriela B.
; Soares, Milena B. P.
; Guimarães, Elisalva T.
; Scotti, Marcus T.
; Rodrigues, Luis Cezar
; Mendonça Júnior, Francisco J. B.
; Campana, Eloísa H.
; Barbosa Filho, José M.
; Guimarães, Hemerson I. F.
; Guerra, Felipe Q. S.
.
In silico and in vitro tests can reveal promising anti-leishmania activity for natural products and their derivatives. The aim of this study was to investigate in silico the pharmacological activities of potential new chalcones and their leishmanicidal potential in vitro. The in silico study was carried out using the PASS, MolPredictX and Molegro Virtual Docker 6.0 programs. Antiparasitic activity was assessed in axenic promastigote and amastigote forms of Leishmania braziliensis. The cytotoxicity tests used the J77G8 cell line. The chalcones exhibited 50% cytotoxic concentration values (CC50) values > 50 μM. Chalcone 4 (named FERAI) presented the best activity with concentration for 50% of promastigotes and intracellular parasites forms (EC50) of 9.75 ± 1.7 and 10.13 ± 1.7 μM for promastigote and amastigote, respectively. Reactive oxygen species (ROS) testing presented increased ROS levels in the parasite at the FERAI concentrations of 10 μM (56.33%), 20 μM (61.76%) and 30 μM (67.13%). Molecular docking revealed interactions (binding energy) between FERAI and the enzymes UDP-glycosyl pyrophosphorylase (-56.8384), dihydroorotate-dehydrogenase (-132.276) and trypanothione-reductase (-151.281). Our results demonstrated the anti-leishmanial activity of chalcones, especially FERAI, with a noted raising of ROS levels in the parasite. Molecular docking revealed dihydroorotate dehydrogenase and trypanothione reductase as potential pharmacological targets for FERAI. antileishmania anti leishmania derivatives PASS 60 6 0 6. programs braziliensis JG J G J77G line CC50 CC (CC50 5 named EC50 EC (EC50 975 9 75 9.7 17 1 7 1. 1013 13 10.1 respectively (ROS 56.33%, 5633 56.33% , 56 33 (56.33%) 2 61.76% 6176 61 76 (61.76% 3 67.13%. 6713 67.13% . 67 (67.13%) binding energy UDPglycosyl UDP glycosyl 56.8384, 568384 56.8384 8384 (-56.8384) dihydroorotatedehydrogenase 132.276 132276 132 276 (-132.276 trypanothionereductase 151.281. 151281 151.281 151 281 (-151.281) antileishmanial leishmanial CC5 (CC5 EC5 (EC5 97 9. 101 10. 563 56.33 (56.33% 61.76 617 (61.76 671 67.13 (67.13% 56838 56.838 838 (-56.8384 132.27 13227 27 (-132.27 15128 151.28 15 28 (-151.281 (CC (EC 56.3 (56.33 61.7 (61.7 67.1 (67.13 5683 56.83 83 (-56.838 132.2 1322 (-132.2 1512 151.2 (-151.28 56. (56.3 61. (61. 67. (67.1 568 56.8 8 (-56.83 132. (-132. 151. (-151.2 (56. (61 (67. (-56.8 (-132 (-151. (56 (6 (67 (-56. (-13 (-151 (5 ( (-56 (-1 (-15 (-5 (-
2.
A Novel Nanocomposite Based on (Zea mays) Corn Cob Biochar and Maghemite for the Competitive Adsorption of Endocrine Disruptor Compounds Zea mays
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Cardoso, Carolina S.
; Silva, Mayara da
; Saatkamp, Rodrigo Henrique
; Caon, Natália B.
; Valentini, Giuliana
; Parize, Alexandre Luis
; Vitali, Luciano
.
Faced with the global challenge of water treatment, the investigation of the removal of endocrine disruptor compounds (EDCs) in aquatic environments is essential to protect human and animals health. In this study, a novel nanocomposite was prepared from biochar from agricultural waste (corn cob) and maghemite (γ-Fe2O3) nanoparticles, named PCCN, to remove four EDCs (triclosan, 17α-ethinylestradiol, methylparaben, and bisphenol A) from aqueous solutions by adsorption. For the characterization of PCCN, the advanced techniques Fourier transform infrared spectroscopy (FTIR), Brunauer-Emmett-Teller analysis (BET), pH of point of zero charge (pHpzc), scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray diffraction (XRD) and thermogravimetry (TGA) were employed. Competitive adsorption equilibrium studies of EDCs were performed with PCCN and compared to unmodified biochar (PCC). The pH effect showed that optimal adsorption of EDCs was at pH 8.0 for PCC and pH 6.0 for PCCN. The salt concentration did not influence EDCs in the adsorption. In the adsorption isotherm, the results fitted the Freundlich isotherm model (R2 > 0.903) and the adsorption kinetics were well described by the pseudo-second-order model (R2 > 0.985). Furthermore, the desorption studies indicated that the PCCN can be reused. Thus, the investigation suggests PCCN has promising potential in the removal of EDCs from wastewater. treatment (EDCs health study corn cob γFe2O3 γFeO γ Fe2O3 Fe O (γ-Fe2O3 nanoparticles triclosan, triclosan (triclosan 17αethinylestradiol, 17αethinylestradiol αethinylestradiol 17α ethinylestradiol, ethinylestradiol α 17α-ethinylestradiol methylparaben A FTIR, FTIR , (FTIR) BrunauerEmmettTeller Brunauer Emmett Teller BET, BET (BET) pHpzc, pHpzc (pHpzc) SEM, SEM (SEM) TEM, TEM (TEM) Xray X ray XRD (XRD TGA (TGA employed PCC. . (PCC) 80 8 0 8. 60 6 6. R2 R (R 0.903 0903 903 pseudosecondorder pseudo second order 0.985. 0985 0.985 985 0.985) Furthermore reused Thus wastewater γFe γFe2O FeO Fe2O (γ-Fe2O (FTIR (BET (pHpzc (SEM (TEM (PCC 0.90 090 90 098 0.98 98 0.9 09 9 0.
3.
[SciELO Preprints] - Timely initiation of antenatal care in adolescent victims of sexual violence: implications for legal abortion in Brazil
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Silva, Luiza
Calu Costa, Janaína
Blumenberg, Cauane
Peixoto Lima, Natália
Paulo Vidaletti Ruas, Luis
dos Santos Costa, Francine
J D Barros, Aluísio
César Wehrmeister, Fernando
Gomes Victora, César
We investigated the timely initiation of antenatal care among Brazilian adolescents to support the national discussion on the gestational age limit for legal abortion. Using data from the Live Births Information System (SINASC) from 2020 to 2022, we correlated timely prenatal care (in the first trimester of pregnancy) with the adolescent's age, region, race/color, and education level. Considering the estimated age at conception, we estimate that 11,607 annual births result from vulnerable rape. Timely initiation increased with age, being 70.2% for all adolescents (<20 years), but only 55.6% for those under 13; 14.1% of adolescents started antenatal care at 22 weeks or more of gestation (28.3% among those <13 years). Timely initiation was lower in the North Region, among Indigenous girls, and among those with low educational attainment. The results challenge the recent legislative proposal to limit legal abortion for victims of vulnerable rape to up to 22 weeks of gestational age. Delays in recognizing pregnancy and communicating with the family contribute to the late initiation of antenatal care and the decision to abort. The proposed deadline for legal abortions will primarily affect the most socioeconomically and racially vulnerable adolescents.
Investigamos o início oportuno do pré-natal em adolescentes brasileiras para subsidiar a discussão nacional sobre o limite de idade gestacional para o aborto legal. Com dados do Sistema de Informação sobre Nascidos Vivos (SINASC) 2020-2022 correlacionamos o início oportuno do pré-natal (primeiro trimestre da gestação) com a idade da adolescente, região, raça/cor e escolaridade. Considerando a idade estimada na concepção, estimamos que 11.607 partos anuais resultam de estupro de vulnerável. O início oportuno aumentou com a idade, sendo de 70,2% para todas as adolescentes (<20 anos), mas de apenas 55,6% para aquelas abaixo de 13 anos; 14,1% das adolescentes iniciaram o pré-natal com 22 semanas ou mais de gestação (28,3% entre <13 anos). O início oportuno foi menor na Região Norte, entre meninas indígenas e entre aquelas com baixa escolaridade. Os resultados questionam o recente projeto de lei de limitar o aborto legal para vítimas de estupro de vulnerável até 22 de semanas de idade gestacional. Demoras no reconhecimento da gestação e na comunicação para a família contribuem para o início tardio do pré-natal e para a decisão de abortar. A proposta de limite do prazo para abortos legais irá atingir principalmente as adolescentes mais vulneráveis em termos socioeconômicos e raciais.
4.
Linfadenectomía extendida en cáncer de colon derecho. Revisión de la evidencia
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Palacios Fuenmayor, Luis José
; Ochoa Pineda, Alejandra
; González Ausique, Paola
; Guzmán Arango, Natalia
.
Resumen El cáncer colorrectal es el tercer cáncer en incidencia a nivel mundial con una alta tasa de morbimortalidad y hasta la fecha la cirugía continúa siendo la única opción curativa. Es por esto que es importante el desarrollo de nuevas técnicas quirúrgicas, junto con la consolidación y refuerzo de los conocimientos, para tener un impacto positivo en el tratamiento de los pacientes con cáncer de colon. Recientemente, se han desarrollado técnicas como la linfadenectomía extendida y la escisión mesocolónica completa en el cáncer de colon derecho, que parecen ser prometedoras en mejorar la sobrevida y el tiempo libre de enfermedad de los pacientes. Sin embargo, existen interrogantes y falta de consenso para recomendar alguna de éstas como el estándar de oro para el manejo quirúrgico de estos pacientes. El objetivo de esta revisión es describir en qué consisten estas técnicas en la cirugía del cáncer de colon derecho, los resultados que se han obtenido al realizarlas y evaluar la pertinencia de este procedimiento en todos los pacientes que vayan a ser sometidos a cirugía curativa de cáncer de colon derecho.
Colon cancer is the third most common cancer worldwide. It is an aggressive cancer, with high morbidity and mortality, and surgery continues to be the only curative option. For this reason, it is important to make big efforts to develop new surgery techniques, and to reinforce and consolidate our knowledge in order to positively impact the treatment of the patients with colon cancer. Nowadays, new techniques of extended lymphadenectomy for colon cancer have been developed, which have shown to have better outcomes in terms of overall survival and local recurrence. Nevertheless, there are still questions about it and lack of consensus to recommend them as a gold standard technique. The objective of this review is to describe these new techniques in right colon cancer surgery, to overview the outcomes of the patients in terms of overall survival, local recurrence, and morbidity and to evaluate if these techniques should be indicated in all patients with right colon cancer who are going to get surgery with curative intent.
5.
Desafíos experimentados por el personal académico docente de Ciencias Médicas de la UCIMED durante la pandemia COVID-19 en Costa Rica
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Alfaro Gurrola, Sylvia
; Villegas Barakat, Mayra
; Cabrera Rojas, Natalia
; Durán Segura, Anaryeri
; Trabado Sagot, Carlos Luis
.
Resumo: O Ensino Superior em todo o mundo durante a pandemia da COVID-19 foi obrigado a repensar, atendendo à diretriz estabelecida pela Organização Mundial da Saúde (OMS) para mitigar o impacto na população. A Costa Rica não foi exceção relativamente à situação que se vivia e especificamente na Universidade de Ciências Médicas (UCIMED), que na ausência de um plano de contingência, viveu uma transição do ensino presencial para o virtual. A presente investigação se focou nos desafios vivenciados pelos docentes dos cursos de Fisioterapia e Nutrição, no período de março a junho de 2020, com a virtualização emergencial. As informações foram coletadas pelo meio de pesquisa desenvolvida no Google Forms®. Uma vez tabulado, foi analisado, interpretado e comparado entre carreiras, aplicando estatística descritiva e revisão bibliográfica para compreender a situação mundial. O estudo determinou que a didática do curso representava um grande desafio para o corpo docente; principalmente a avaliação da aprendizagem, a participação dos estudantes, o uso de ferramentas virtuais e problemas de conectividade. Ao comparar as carreiras, identificou-se que pouca formação, menos anos de experiência docente e baixa interação com plataformas virtuais foram fatores que aumentaram a percepção dos desafios. Ao enfrentá-los, enriqueceu-se a experiência docente na gestão das TIC e com ela a transformação do Ensino Superior.
Resumen: La educación superior a nivel mundial durante la pandemia COVID-19 se vio obligada a replantearse, dada la directriz establecida por la Organización Mundial de la Salud (OMS) para mitigar el impacto en la población. Costa Rica no fue la excepción respecto a la circunstancia que se vivía y, específicamente, la Universidad de Ciencias Médicas (UCIMED), ante la ausencia de un plan de contingencia, experimentó una transición de la enseñanza presencial a virtual. Debido a ello, la presente investigación tuvo un enfoque cuantitativo y exploró los desafíos que experimentó el personal docente de las carreras de Fisioterapia y Nutrición, durante el periodo de marzo a junio del 2020, con la virtualización de emergencia. La información se recopiló a través de un cuestionario elaborado en Google Forms®; una vez tabulada, se analizó, interpretó y comparó entre carreras, apli- cando estadística descriptiva y una revisión bibliográfica para comprender la situación a nivel mundial. El estudio determinó que la didáctica del curso representó un alto desafío para el cuerpo docente; principalmente, la evaluación del aprendizaje, la participación del estudiantado, el uso de las herramientas virtuales y los problemas de conectividad. Al comparar las carreras, se identificó que la poca capacitación, la menor cantidad de años de experiencia docente y la baja interacción con plataformas virtuales, fueron factores que aumentaron la percepción de los desafíos. A partir de la confrontación de los desafíos, se enriqueció la experiencia docente en el manejo de las tecnologías de la información y comunicación (TIC) y con ello la transformación de la educación superior.
Abstract: During the COVID-19 pandemic, higher education worldwide was forced to restructure itself according to guidelines established by the World Health Organization (WHO) to mitigate the impact of the pandemic on the population. Costa Rica was no exception. In the absence of a contingency plan, the University of Medical Sciences (UCIMED) underwent a transition from face-to-face to virtual teaching. This study focused on the challenges experienced by physical therapy and nutrition faculty during the period from March to June 2020, due to the emergency virtualization. The information was collected through a Google Forms® survey; once tabulated, the data was analyzed, interpreted and compared between the professions, implementing descriptive statistics and a bibliographic review to better understand the situation at a global level. The study showed that the didactics of the course was a great challenge for the teachers, mainly in terms of learning assessment, student participation, use of virtual tools and connectivity problems. When comparing professions, it was found that limited training, fewer years of teaching experience, and less interaction with virtual platforms were factors that increased the perception of challenges. Confronting the challenges enriched the teaching experience in terms of ICT management and thus the transformation of higher education.
6.
Paraganglioma periaórtico y efusión pericárdica en un perro Golden Retriever: Reporte de caso
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Revista de Investigaciones Veterinarias del Perú
- Journal Metrics
ABSTRACT The case of a 10-year-old Golden Retriever dog treated at the ASMEVET veterinary hospital in the city of Tunja, Colombia is presented. The owner reported that the patient had an intermittent cough for 2 months. The physical examination revealed the patient to be hyperactive, body condition 4/5, and faint heart sounds. Echocardiography, chest xray, and electrocardiogram were performed, revealing pericardial effusion, increased size of the cardiac silhouette, and deviation of the S-T segment. Initially, treatment was attempted with antibiotics, diuretics and anti-inflammatory agents, without a favourable response. Two months later, it was necessary to perform emergency pericardiocentesis due to cardiac tamponade, and partial subphrenic pericardiectomy. Histopathological analysis revealed a paraganglioma. The patient survived 673 days after surgical treatment.
RESUMEN Se presenta el caso de un canino de 10 años de edad, raza Golden Retriever, atendido en el hospital veterinario ASMEVET en la ciudad de Tunja, Colombia. El propietario reportó que el paciente tubo tos intermitente desde hace 2 meses. Al examen físico se evidencia al paciente hiperactivo, condición corporal 4/5, y con sonidos cardíacos apagados. Se realiza ecocardiografía, radiografía de tórax, y electrocardiograma, encontrando efusión pericárdica, aumento de tamaño de la silueta cardiaca y desviación del segmento S-T. Inicialmente se intentó tratar con antibiótico, diurético y antiinflamatorio, sin respuesta favorable. Dos meses después fue necesario realizar pericardiocentesis de urgencia por el taponamiento cardíaco, y pericardiectomía subfrénica parcial. El análisis histopatológico dio como resultado un paraganglioma. El paciente logra sobrevivir 673 días después del tratamiento quirúrgico.
7.
Las misiones médicas al Policlínico PAMS en Chincha: evolución del modelo de misión
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Valdivieso Rodriguez, Manuel
; Aguinaga Zapata, Liliana
; Espinoza, Luis A.
; Ferrari Gabilondo, Natalia
; Garrido Lecca del Rio, Guillermo
; Janke, Walter H.
; Leiva Mejia, Veronica
; Rios Perez, Jorge
; Sjogren, Maria H.
; Tello Del Mar, Solania
; Vega Monteferri, Luis
; Zeppilli Diaz, Juan Eduardo
.
ABSTRACT We present the experience of the Polyclinic of the Peruvian American Medical Society (PAMS) in Chincha, in the execution of medical educational missions in the Chincha region. The PAMS Polyclinic provides general and specialized medical care to the population of the area, six days a week. In addition, the Polyclinic receives medical missions generally coming from the EE.UU. Since 2011, we have received 43 medical missions. The composition and nature of the missions have changed over time. The first years attracted specialists with the emphasis on bringing equipment and supplies to improve the infrastructure of the Polyclinic. We are now limited by the reluctance of volunteers to come to Peru in part because the U.S. government considers travel to Peru to be high-risk. This limitation has given us the opportunity to do medical missions together with two excellent Peruvian universities. This experience has been positive.
RESUMEN Presentamos la experiencia del Policlínico de la Peruvian American Medical Society (PAMS) en Chincha, en la ejecución de misiones médico-educativas en la región Chincha. El Policlínico PAMS presta atención médica general y especializada a la población de la zona, seis días a la semana. Además, recibe misiones médicas que vienen generalmente de los EE. UU. Desde 2011, se han recibido 43 misiones médicas. La composición y la naturaleza de las misiones han cambiado con el tiempo. Los primeros años se atraía a especialistas con el énfasis de traer equipos e insumos para mejorar la infraestructura del Policlínico. Ahora estamos limitados por la renuencia de voluntarios de venir al Perú en parte debido a que el gobierno americano considera que viajes al Perú son de alto riesgo. Esta limitación nos ha brindado la oportunidad de hacer misiones médicas juntamente con dos excelentes universidades peruanas. La experiencia ha sido positiva.
8.
Cx43 hemichannels and panx1 channels contribute to ethanol-induced astrocyte dysfunction and damage
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Gómez, Gonzalo I.
; Alvear, Tanhia F.
; Roa, Daniela A.
; Farias-Pasten, Arantza
; Vergara, Sergio A.
; Mellado, Luis A.
; Martinez-Araya, Claudio J.
; Prieto-Villalobos, Juan
; García-Rodríguez, Claudia
; Sánchez, Natalia
; Sáez, Juan C.
; Ortíz, Fernando C.
; Orellana, Juan A.
.
Abstract Background Alcohol, a widely abused drug, significantly diminishes life quality, causing chronic diseases and psychiatric issues, with severe health, societal, and economic repercussions. Previously, we demonstrated that non-voluntary alcohol consumption increases the opening of Cx43 hemichannels and Panx1 channels in astrocytes from adolescent rats. However, whether ethanol directly affects astroglial hemichannels and, if so, how this impacts the function and survival of astrocytes remains to be elucidated. Results Clinically relevant concentrations of ethanol boost the opening of Cx43 hemichannels and Panx1 channels in mouse cortical astrocytes, resulting in the release of ATP and glutamate. The activation of these large-pore channels is dependent on Toll-like receptor 4, P2X7 receptors, IL-1β and TNF-α signaling, p38 mitogen-activated protein kinase, and inducible nitric oxide (NO) synthase. Notably, the ethanol-induced opening of Cx43 hemichannels and Panx1 channels leads to alterations in cytokine secretion, NO production, gliotransmitter release, and astrocyte reactivity, ultimately impacting survival. Conclusion Our study reveals a new mechanism by which ethanol impairs astrocyte function, involving the sequential stimulation of inflammatory pathways that further increase the opening of Cx43 hemichannels and Panx1 channels. We hypothesize that targeting astroglial hemichannels could be a promising pharmacological approach to preserve astrocyte function and synaptic plasticity during the progression of various alcohol use disorders.
9.
Maternal stress during pregnancy alters circulating small extracellular vesicles and enhances their targeting to the placenta and fetus
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Sánchez-Rubio, Mario
; Abarzúa-Catalán, Lorena
; Valle, Ana del
; Méndez-Ruette, Maxs
; Salazar, Natalia
; Sigala, Jacinta
; Sandoval, Soledad
; Godoy, María Inés
; Luarte, Alejandro
; Monteiro, Lara J.
; Romero, Roberto
; Choolani, Mahesh A.
; Wyneken, Úrsula
; Illanes, Sebastián E.
; Bátiz, Luis Federico
.
Abstract Background Maternal psychological distress during pregnancy can negatively impact fetal development, resulting in long-lasting consequences for the offspring. These effects show a sex bias. The mechanisms whereby prenatal stress induces functional and/or structural changes in the placental-fetal unit remain poorly understood. Maternal circulating small extracellular vesicles (sEVs) are good candidates to act as “stress signals” in mother-to-fetus communication. Using a repetitive restraint-based rat model of prenatal stress, we examined circulating maternal sEVs under stress conditions and tested whether they could target placental-fetal tissues. Results Our mild chronic maternal stress during pregnancy paradigm induced anhedonic-like behavior in pregnant dams and led to intrauterine growth restriction (IUGR), particularly in male fetuses and placentas. The concentration and cargo of maternal circulating sEVs changed under stress conditions. Specifically, there was a significant reduction in neuron-enriched proteins and a significant increase in astrocyte-enriched proteins in blood-borne sEVs from stressed dams. To study the effect of repetitive restraint stress on the biodistribution of maternal circulating sEVs in the fetoplacental unit, sEVs from pregnant dams exposed to stress or control protocol were labeled with DiR fluorescent die and injected into pregnant females previously exposed to control or stress protocol. Remarkably, maternal circulating sEVs target placental/fetal tissues and, under stress conditions, fetal tissues are more receptive to sEVs. Conclusion Our results suggest that maternal circulating sEVs can act as novel mediators/modulators of mother-to-fetus stress communication. Further studies are needed to identify placental/fetal cellular targets of maternal sEVs and characterize their contribution to stress-induced sex-specific placental and fetal changes.
10.
Os Biomarcadores podem ser Utilizados para Prever Recorrência de Arritmia após a Ablação de Fibrilação Atrial Guiada pelo Ablation-Index? AblationIndex Ablation Index Ablation-Index
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Palma, Andreia
; Sousa, Pedro A.
; Saleiro, Carolina
; Barra, Sérgio
; António, Natália
; Adão, Luis
; Primo, João
; Lebreiro, Ana
; Fonseca, Paulo
; Elvas, Luís
; Gonçalves, Lino
.
Resumo Fundamento: O software ablation index (AI) permitiu melhorar os resultados da ablação de fibrilação atrial (FA), mas as taxas de recorrência permanecem significativas. Biomarcadores séricos específicos têm sido associados a essa recorrência. Objetivos: Avaliar se certos biomarcadores podem ser utilizados (individualmente ou combinados) para predizer a recorrência de FA pós ablação guiada pelo AI. Métodos: Estudo multicêntrico, observacional, prospectivo de pacientes consecutivos, encaminhados para ablação de FA de janeiro de 2018 a março de 2021. Hemoglobina, peptídeo natriurético cerebral (BNP), proteína C reativa, troponina I ultrassensível, clearance de creatinina, Hormônio Tireoestimulante (TSH), e Tiroxina livre (T4) foram avaliados quanto à capacidade de prever a recorrência de arritmias durante o acompanhamento. Valores de p <0,05 foram aceitos como estatisticamente significativos. Resultados: Um total de 593 pacientes foram incluídos – 412 com FA paroxística e 181 com FA persistente. Durante o seguimento médio de 24±6 meses, 76,4% não apresentaram recidiva após ablação. Individualmente, os biomarcadores demonstraram um valor preditivo baixo ou nulo para recorrência. No entanto, TSH >1,8 μUI/mL [HR=1,82 (IC95%, 1,89-2,80), p=0,006] foi um preditor independente de recorrência. Avaliando-se a combinação de TSH, FT4 e BNP, a adição de cada valor “anormal” foi associada a uma menor sobrevida livre de recorrência (87,1% se nenhum vs. 83,5% se um vs. 75,1% se dois vs. 43,3% se três biomarcadores, p<0,001). Doentes com três biomarcadores “anormais” apresentaram três vezes maior probabilidade de recorrência de FA, comparativamente aos que não apresentaram nenhum biomarcador “anormal” (HR=2,88 [IC95%, 1,39-5,17], p=0,003). Conclusões: Quando combinados, valores anormais de TSH, FT4 e BNP podem ser uma ferramenta útil para prever a recorrência de FA pós ablação guiada pelo AI. Fundamento AI (AI , (FA) significativas Objetivos individualmente combinados Métodos multicêntrico observacional consecutivos 201 2021 Hemoglobina (BNP) reativa ultrassensível creatinina (TSH) T4 T (T4 acompanhamento 005 0 05 <0,0 significativos Resultados 59 41 18 persistente 246 24 6 24± meses 764 76 4 76,4 Individualmente entanto 1 8 >1, μUImL μUI mL HR=1,82 HR182 HR 82 [HR=1,8 IC95%, IC95 IC (IC95% 1,892,80, 189280 1,89 2,80 89 2 80 1,89-2,80) p=0,006 p0006 006 Avaliandose Avaliando FT anormal “anormal 87,1% 871 87 (87,1 vs 835 83 5 83,5 751 75 75,1 433 43 3 43,3 p<0,001. p0001 p<0,001 . 001 p<0,001) “anormais HR=2,88 HR288 88 (HR=2,8 [IC95% 1,395,17, 139517 1,39 5,17 39 17 1,39-5,17] p=0,003. p0003 p=0,003 003 p=0,003) Conclusões (FA 20 202 (BNP (TSH (T 00 <0, 7 76, >1 HR=1,8 HR18 [HR=1, IC95% IC9 (IC95 892 1,892,80 18928 189 1,8 280 2,8 1,89-2,80 p=0,00 p000 87,1 (87, 83, 75, 43, p<0,00 HR=2,8 HR28 (HR=2, [IC95 395 1,395,17 13951 139 1,3 517 5,1 1,39-5,17 <0 > HR=1, HR1 [HR=1 (IC9 1,892,8 1892 1, 28 2, 1,89-2,8 p=0,0 p00 87, (87 p<0,0 HR=2, HR2 (HR=2 [IC9 1,395,1 1395 13 51 5, 1,39-5,1 < HR=1 [HR= (IC 1,892, 1,89-2, p=0, p0 (8 p<0, HR=2 (HR= [IC 1,395, 1,39-5, HR= [HR 1,892 1,89-2 p=0 ( p<0 (HR 1,395 1,39-5 1,89- p= p< 1,39-
Abstract Background: Ablation Index (AI) software has allowed better atrial fibrillation (AF) ablation results, but recurrence rates remain significant. Specific serum biomarkers have been associated with this recurrence. Objectives: To evaluate whether certain biomarkers could be used (either individually or combined) to predict arrhythmia recurrence after AI-guided AF ablation. Methods: Prospective multicenter observational study of consecutive patients referred for AF ablation from January 2018 to March 2021. Hemoglobin, brain natriuretic peptide (BNP), C-reactive protein, high sensitivity cardiac troponin I, creatinine clearance, thyroid-stimulating hormone (TSH) and free thyroxine (FT4) were assessed for their ability to predict arrhythmia recurrence during follow-up. Statistical significance was accepted for p values of<0.05. Results: A total of 593 patients were included - 412 patients with paroxysmal AF and 181 with persistent AF. After a mean follow-up of 24±6 months, overall single-procedure freedom from atrial arrhythmia was 76.4%. Individually, all biomarkers had no or only modest predictive power for recurrence. However, a TSH value >1.8 μUI/mL (HR=1.82 [95% CI, 1.89-2.80], p=0.006) was an independent predictor of arrhythmia recurrence. When assessing TSH, FT4 and BNP values in combination, each additional “abnormal” biomarker value was associated with a lower freedom from arrhythmia recurrence (87.1 % for no biomarker vs. 83.5% for one vs. 75.1% for two vs. 43.3% for three biomarkers, p<0.001). Patients with three “abnormal” biomarkers had a threefold higher risk of AF recurrence compared with no “abnormal” biomarker (HR=2.88 [95% CI, 1.39-5.17], p=0.003). Conclusions: When used in combination, abnormal TSH, FT4 and BNP values can be a useful tool for predicting arrhythmia recurrence after AI-guided AF ablation. Background AI (AI (AF results significant Objectives either combined AIguided guided Methods 201 2021 Hemoglobin BNP, , (BNP) Creactive C reactive protein I clearance thyroidstimulating thyroid stimulating (TSH FT (FT4 followup. followup follow up. up of005 0 05 of<0.05 Results 59 41 18 246 24 6 24± months singleprocedure single procedure 764 76 4 76.4% Individually However 1 8 >1. μUImL μUI mL HR=1.82 HR182 HR 82 (HR=1.8 95% 95 [95 CI 1.892.80, 189280 1.89 2.80 89 2 80 1.89-2.80] p=0.006 p0006 006 combination “abnormal 87.1 871 87 (87. vs 835 83 5 83.5 751 75 75.1 433 43 3 43.3 p<0.001. p0001 p<0.001 . 001 p<0.001) HR=2.88 HR288 88 (HR=2.8 1.395.17, 139517 1.39 5.17 39 17 1.39-5.17] p=0.003. p0003 p=0.003 003 p=0.003) Conclusions 20 202 (BNP (FT of00 of<0.0 7 76.4 >1 HR=1.8 HR18 (HR=1. 9 [9 892 1.892.80 18928 189 1.8 280 2.8 1.89-2.80 p=0.00 p000 00 87. (87 83. 75. 43. p<0.00 HR=2.8 HR28 (HR=2. 395 1.395.17 13951 139 1.3 517 5.1 1.39-5.17 of0 of<0. 76. > HR=1. HR1 (HR=1 [ 1.892.8 1892 1. 28 2. 1.89-2.8 p=0.0 p00 (8 p<0.0 HR=2. HR2 (HR=2 1.395.1 1395 13 51 5. 1.39-5.1 of<0 HR=1 (HR= 1.892. 1.89-2. p=0. p0 ( p<0. HR=2 1.395. 1.39-5. of< HR= (HR 1.892 1.89-2 p=0 p<0 1.395 1.39-5 1.89- p= p< 1.39-
11.
The decline in postural balance has a negative impact on the performance of functional tasks in individuals with Parkinson's Disease Parkinsons Parkinson s
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Luna, Natália Mariana Silva
; Bobbio, Tatiana Godoy
; Graaf, Myriam de
; Greve, Júlia Maria D'Andrea
; Ernandes, Rita de Cássia
; Dias, Aluane Silva
; Lino, Matheus Henrique dos Santos
; Soares-Junior, Jose Maria
; Baracat, Edmund Chada
; Mochizuki, Luis
; Brech, Guilherme Carlos
; Alonso, Angelica Castilho
.
Abstract Introduction An accurate assessment of balance problems is critical for decreasing the risk of falling in patients with Parkinson's Disease (PD). Reliable diagnostic tools such as Computerized Dynamic Posturography (CDP) are not feasible for the clinical setting. Therefore, the present study's aim was to assess the correlation between the clinical Balance Evaluation Systems Test (BESTest) and CDP. Methods 20 male older adults with Parkinson's Disease (PD) were included in this study. Participants first executed the Sit-To-Stand (STS), Step/Quick turn (SQT), and Step Up and Over (SUO) tests on a Balance Master® force platform, followed by a clinical balance evaluation using the BESTest. Results Four outcomes of the CDP were negatively correlated with one or more BESTest domains or total BESTest score: STS sway velocity was negatively correlated with the anticipatory postural adjustment (p = 0.02) and sensory orientation (p = 0.01) domains. SQT turn time was negatively correlated with biomechanical restriction (for turns to the left, p = 0.01, and right, p = 0.03, respectively), postural response (p = 0.01, p = 0.01), dynamic balance during gait (p = 0.007, p = 0.001), and total score (p = 0.02, p = 0.01). Step over time to the right in SUP was negatively correlated with the limits of the stability domain (p = 0.002) and total BESTest score (p = 0.020). SUO impact index was negatively correlated with the anticipatory postural adjustment domain (p = 0.01). Conclusion This study shows that several BESTest domains are significantly correlated with CDP outcomes, demonstrating that the BESTest can be used as a more clinically feasible alternative for computerized posturography, without loss of information. Parkinsons Parkinson s PD. PD . (CDP setting Therefore studys (BESTest 2 (PD SitToStand Sit To Stand STS, , (STS) StepQuick Quick SQT, (SQT) (SUO Master platform 0.02 002 0 02 0.01 001 01 left 003 03 0.03 respectively, respectively respectively) 0007 007 0.007 0.001, 0001 0.001 0.001) 0.01. 0.002 0002 0.020. 0020 0.020 020 0.020) posturography information (STS (SQT 0.0 00 000 0.00 0.
12.
Validation study of obstetric hospitalization data held on the Brazilian National Health System Hospital Information System for maternal morbidity surveillance: Brazil, 2021-2022
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Domingues, Rosa Maria Soares Madeira
; Meijinhos, Lana dos Santos
; Guillen, Luis Carlos Torres
; Dias, Marcos Augusto Bastos
; Saraceni, Valéria
; Pinheiro, Rejane Sobrinho
; Paiva, Natália Santana
; Coeli, Cláudia Medina
.
ABSTRACT Objective To validate the Brazilian National Health System Hospital Information System (SIH/SUS) for maternal morbidity surveillance. Methods This was a cross-sectional study conducted in 2021/2022, taking as its reference a national study on maternal morbidity (MMG) conducted in 50 public and 28 private hospitals; we compared SIH/SUS and MMG data for hospitalization frequency, reason and type of discharge and calculated sensitivity, specificity, positive and negative likelihood ratios for seven diagnoses and four procedures. Results Hospitalizations identified on SIH/SUS (32,212) corresponded to 95.1% of hospitalizations assessed by MMG (33,867), with lower recording on SIH/SUS (85.5%) for private hospitals [10,036 (SIH/SUS)]; 11,742 (MMG)]; compared to MMG, SIH/SUS had a lower proportion of hospitalizations due to “complications during pregnancy” (9.7% versus 16.5%) as well as under-recording of all diagnoses and procedures assessed, except “ectopic pregnancy”. Conclusion Better recording of diagnoses and procedures on SIH/SUS is essential for its use in maternal morbidity surveillance.
RESUMEN Objetivo Validar el Sistema de Información Hospitalaria del Sistema Único de Salud (SIH/SUS) para vigilancia de la morbilidad materna. Métodos Estudio transversal, 2021/2022, utilizando como referencia datos de estudio nacional de morbilidad materna (MMG) realizado en 50 hospitales públicos y 28 privados; comparando: frecuencia, motivo y tipo de alta de internaciones en SIH/SUS y MMG y calculando sensibilidad, especificidad y razones de probabilidad positivos y negativos para siete diagnósticos y cuatro procedimientos. Resultados Las internaciones identificadas en SIH/SUS (32.212) correspondieron al 95,1% de internaciones evaluadas en MMG (33.867), observándose menor registro en SIH/SUS (85,5%) en hospitales privados [10.036 (SIH/SUS)]; 11.742 (MMG)]; comparado con MMG, SIH/SUS tuvo menor proporción de internaciones por “complicaciones durante el embarazo” (9,7% vs 16,5%), así como subregistro de todos los diagnósticos y procedimientos evaluados, excepto “embarazo ectópico”. Conclusión Mejor registro de diagnósticos y procedimientos en SIH/SUS es fundamental para su uso en la vigilancia de la morbilidad materna.
RESUMO Objetivo Validar o Sistema de Informações Hospitalares do Sistema Único de Saúde (SIH/SUS) para vigilância da morbidade materna. Métodos Estudo transversal, de 2021-2022, utilizando-se como referência dados de estudo nacional sobre morbidade materna (MMG) realizado em 50 hospitais públicos e 28 privados; foram comparados frequência, motivo e tipo de saída das internações, segundo SIH/SUS e MMG, e calculadas sensibilidade, especificidade, razão de verossimilhança positiva e negativa para sete diagnósticos e quatro procedimentos. Resultados Internações identificadas no SIH/SUS (32.212) corresponderam a 95,1% das internações avaliadas no MMG (33.867), tendo-se observado menor registro no SIH/SUS (85,5%) em hospitais privados [10.036 (SIH/SUS); 11.742 (MMG)]; comparado ao MMG, o SIH/SUS apresentou menor proporção de internações por “intercorrências na gestação” (9,7% versus 16,5%), bem como sub-registro de todos os diagnósticos e procedimentos avaliados, exceto “gestação ectópica”. Conclusão Melhor registro de diagnósticos e procedimentos no SIH/SUS é essencial para sua utilização na vigilância da morbidade materna.
13.
Validation study of obstetric hospitalization data held on the Brazilian National Health System Hospital Information System for maternal morbidity surveillance: Brazil, 2021-2022 surveillance Brazil 20212022 2021 2022 2021-202 2021202 202 2021-20 202120 20 2021-2 20212 2 2021-
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Domingues, Rosa Maria Soares Madeira
; Meijinhos, Lana dos Santos
; Guillen, Luis Carlos Torres
; Dias, Marcos Augusto Bastos
; Saraceni, Valéria
; Pinheiro, Rejane Sobrinho
; Paiva, Natália Santana
; Coeli, Cláudia Medina
.
RESUMO Objetivo Validar o Sistema de Informações Hospitalares do Sistema Único de Saúde (SIH/SUS) para vigilância da morbidade materna. Métodos Estudo transversal, de 2021-2022, utilizando-se como referência dados de estudo nacional sobre morbidade materna (MMG) realizado em 50 hospitais públicos e 28 privados; foram comparados frequência, motivo e tipo de saída das internações, segundo SIH/SUS e MMG, e calculadas sensibilidade, especificidade, razão de verossimilhança positiva e negativa para sete diagnósticos e quatro procedimentos. Resultados Internações identificadas no SIH/SUS (32.212) corresponderam a 95,1% das internações avaliadas no MMG (33.867), tendo-se observado menor registro no SIH/SUS (85,5%) em hospitais privados [10.036 (SIH/SUS); 11.742 (MMG)]; comparado ao MMG, o SIH/SUS apresentou menor proporção de internações por “intercorrências na gestação” (9,7% versus 16,5%), bem como sub-registro de todos os diagnósticos e procedimentos avaliados, exceto “gestação ectópica”. Conclusão Melhor registro de diagnósticos e procedimentos no SIH/SUS é essencial para sua utilização na vigilância da morbidade materna. SIHSUS SIH SUS (SIH/SUS transversal 20212022, 20212022 2021 2022, 2022 2021-2022 utilizandose utilizando se (MMG 5 2 frequência sensibilidade especificidade 32.212 32212 32 212 (32.212 951 95 1 95,1 33.867, 33867 33.867 , 33 867 (33.867) tendose tendo 85,5% 855 85 (85,5% 10.036 10036 10 036 [10.03 11742 11 742 11.74 (MMG)] intercorrências gestação 9,7% 97 9 7 (9,7 16,5%, 165 16,5% 16 16,5%) subregistro sub avaliados ectópica. ectópica . ectópica” 2021202 202 2021-202 32.21 3221 3 21 (32.21 95, 3386 33.86 86 (33.867 85,5 8 (85,5 10.03 1003 03 [10.0 1174 74 11.7 9,7 (9, 16,5 202120 20 2021-20 32.2 322 (32.2 338 33.8 (33.86 85, (85, 10.0 100 0 [10. 117 11. 9, (9 16, 20212 2021-2 32. (32. 33. (33.8 (85 10. [10 ( 2021- (32 (33. (8 [1 (3 (33 [
RESUMEN Objetivo Validar el Sistema de Información Hospitalaria del Sistema Único de Salud (SIH/SUS) para vigilancia de la morbilidad materna. Métodos Estudio transversal, 2021/2022, utilizando como referencia datos de estudio nacional de morbilidad materna (MMG) realizado en 50 hospitales públicos y 28 privados; comparando: frecuencia, motivo y tipo de alta de internaciones en SIH/SUS y MMG y calculando sensibilidad, especificidad y razones de probabilidad positivos y negativos para siete diagnósticos y cuatro procedimientos. Resultados Las internaciones identificadas en SIH/SUS (32.212) correspondieron al 95,1% de internaciones evaluadas en MMG (33.867), observándose menor registro en SIH/SUS (85,5%) en hospitales privados [10.036 (SIH/SUS)]; 11.742 (MMG)]; comparado con MMG, SIH/SUS tuvo menor proporción de internaciones por “complicaciones durante el embarazo” (9,7% vs 16,5%), así como subregistro de todos los diagnósticos y procedimientos evaluados, excepto “embarazo ectópico”. Conclusión Mejor registro de diagnósticos y procedimientos en SIH/SUS es fundamental para su uso en la vigilancia de la morbilidad materna. SIHSUS SIH SUS (SIH/SUS transversal 20212022 2021 2022 2021/2022 (MMG 5 2 comparando frecuencia sensibilidad 32.212 32212 32 212 (32.212 951 95 1 95,1 33.867, 33867 33.867 , 33 867 (33.867) 85,5% 855 85 (85,5% 10.036 10036 10 036 [10.03 (SIH/SUS)] 11742 11 742 11.74 (MMG)] complicaciones embarazo 9,7% 97 9 7 (9,7 16,5%, 165 16,5% 16 16,5%) evaluados ectópico. ectópico . ectópico” 2021202 202 2021/202 32.21 3221 3 21 (32.21 95, 3386 33.86 86 (33.867 85,5 8 (85,5 10.03 1003 03 [10.0 1174 74 11.7 9,7 (9, 16,5 202120 20 2021/20 32.2 322 (32.2 338 33.8 (33.86 85, (85, 10.0 100 0 [10. 117 11. 9, (9 16, 20212 2021/2 32. (32. 33. (33.8 (85 10. [10 ( 2021/ (32 (33. (8 [1 (3 (33 [
ABSTRACT Objective To validate the Brazilian National Health System Hospital Information System (SIH/SUS) for maternal morbidity surveillance. Methods This was a cross-sectional study conducted in 2021/2022, taking as its reference a national study on maternal morbidity (MMG) conducted in 50 public and 28 private hospitals; we compared SIH/SUS and MMG data for hospitalization frequency, reason and type of discharge and calculated sensitivity, specificity, positive and negative likelihood ratios for seven diagnoses and four procedures. Results Hospitalizations identified on SIH/SUS (32,212) corresponded to 95.1% of hospitalizations assessed by MMG (33,867), with lower recording on SIH/SUS (85.5%) for private hospitals [10,036 (SIH/SUS)]; 11,742 (MMG)]; compared to MMG, SIH/SUS had a lower proportion of hospitalizations due to “complications during pregnancy” (9.7% versus 16.5%) as well as under-recording of all diagnoses and procedures assessed, except “ectopic pregnancy”. Conclusion Better recording of diagnoses and procedures on SIH/SUS is essential for its use in maternal morbidity surveillance. SIHSUS SIH SUS (SIH/SUS surveillance crosssectional cross sectional 20212022 2021 2022 2021/2022 (MMG 5 2 frequency sensitivity specificity 32,212 32212 32 212 (32,212 951 95 1 95.1 33,867, 33867 33,867 , 33 867 (33,867) 85.5% 855 85 (85.5% 10,036 10036 10 036 [10,03 (SIH/SUS)] 11742 11 742 11,74 (MMG)] complications pregnancy 9.7% 97 9 7 (9.7 16.5% 165 16 underrecording under ectopic pregnancy. . 2021202 202 2021/202 32,21 3221 3 21 (32,21 95. 3386 33,86 86 (33,867 85.5 8 (85.5 10,03 1003 03 [10,0 1174 74 11,7 9.7 (9. 16.5 202120 20 2021/20 32,2 322 (32,2 338 33,8 (33,86 85. (85. 10,0 100 0 [10, 117 11, 9. (9 16. 20212 2021/2 32, (32, 33, (33,8 (85 10, [10 ( 2021/ (32 (33, (8 [1 (3 (33 [
14.
Insidious Synovial Sarcoma of Bone in a Patient with Rheumatoid Arthritis
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Villarreal, Juan Carlos Reyes
; Pineda-Galindo, Luis Francisco
; Vera-Lastra, Olga
; Quispe-Susara, Elizabeth Natalia
; Navarro, Alberto Ordinola
.
Resumo Sarcoma sinovial é uma rara malignidade de origem mesenquimal; a abordagem diagnóstica geralmente começa documentando um tumor de tecido mole; no entanto, resulta em um diagnóstico desafiador quando é mais profundo, de pequeno porte ou primário do osso. O presente relato descreve um paciente que apresentou dor insidiosa no quadril atribuída a artrite reumatoide, com desfecho fatal devido a doenças de base e complicações cirúrgicas. A subestimação da dor no quadril, principalmente quando não há massa palpável, pode atrasar o diagnóstico. mesenquimal mole entanto profundo osso reumatoide cirúrgicas palpável
Abstract Synovial sarcoma is a rare malignity of mesenchymal origin; the diagnostic approach usually begins by documenting a soft tissue tumor; however, it results in a challenging diagnosis when it is more profound, of small size, or primary from the bone. The present report describes a patient who presented insidious onset hip pain attributed to rheumatoid arthritis, with a fatal outcome due to baseline disease and surgery complications. The underestimation of hip pain, mainly when there is no palpable mass, may delay the diagnosis. origin tumor however profound size bone arthritis complications mass
15.
Catálogo Taxonômico da Fauna do Brasil: Setting the baseline knowledge on the animal diversity in Brazil Brasil
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Boeger, Walter A.
; Valim, Michel P.
; Zaher, Hussam
; Rafael, José A.
; Forzza, Rafaela C.
; Percequillo, Alexandre R.
; Serejo, Cristiana S.
; Garraffoni, André R.S.
; Santos, Adalberto J.
; Slipinski, Adam
; Linzmeier, Adelita M.
; Calor, Adolfo R.
; Garda, Adrian A.
; Kury, Adriano B.
; Fernandes, Agatha C.S.
; Agudo-Padrón, Aisur I.
; Akama, Alberto
; Silva Neto, Alberto M. da
; Burbano, Alejandro L.
; Menezes, Aleksandra
; Pereira-Colavite, Alessandre
; Anichtchenko, Alexander
; Lees, Alexander C.
; Bezerra, Alexandra M.R.
; Domahovski, Alexandre C.
; Pimenta, Alexandre D.
; Aleixo, Alexandre L.P.
; Marceniuk, Alexandre P.
; Paula, Alexandre S. de
; Somavilla, Alexandre
; Specht, Alexandre
; Camargo, Alexssandro
; Newton, Alfred F.
; Silva, Aline A.S. da
; Santos, Aline B. dos
; Tassi, Aline D.
; Aragão, Allan C.
; Santos, Allan P.M.
; Migotto, Alvaro E.
; Mendes, Amanda C.
; Cunha, Amanda
; Chagas Júnior, Amazonas
; Sousa, Ana A.T. de
; Pavan, Ana C.
; Almeida, Ana C.S.
; Peronti, Ana L.B.G.
; Henriques-Oliveira, Ana L.
; Prudente, Ana L.
; Tourinho, Ana L.
; Pes, Ana M.O.
; Carmignotto, Ana P.
; Wengrat, Ana P.G. da Silva
; Dornellas, Ana P.S.
; Molin, Anamaria Dal
; Puker, Anderson
; Morandini, André C.
; Ferreira, André da S.
; Martins, André L.
; Esteves, André M.
; Fernandes, André S.
; Roza, André S.
; Köhler, Andreas
; Paladini, Andressa
; Andrade, Andrey J. de
; Pinto, Ângelo P.
; Salles, Anna C. de A.
; Gondim, Anne I.
; Amaral, Antonia C.Z.
; Rondón, Antonio A.A.
; Brescovit, Antonio
; Lofego, Antônio C.
; Marques, Antonio C.
; Macedo, Antonio
; Andriolo, Artur
; Henriques, Augusto L.
; Ferreira Júnior, Augusto L.
; Lima, Aurino F. de
; Barros, Ávyla R. de A.
; Brito, Ayrton do R.
; Romera, Bárbara L.V.
; Vasconcelos, Beatriz M.C. de
; Frable, Benjamin W.
; Santos, Bernardo F.
; Ferraz, Bernardo R.
; Rosa, Brunno B.
; Sampaio, Brunno H.L.
; Bellini, Bruno C.
; Clarkson, Bruno
; Oliveira, Bruno G. de
; Corrêa, Caio C.D.
; Martins, Caleb C.
; Castro-Guedes, Camila F. de
; Souto, Camilla
; Bicho, Carla de L.
; Cunha, Carlo M.
; Barboza, Carlos A. de M.
; Lucena, Carlos A.S. de
; Barreto, Carlos
; Santana, Carlos D.C.M. de
; Agne, Carlos E.Q.
; Mielke, Carlos G.C.
; Caetano, Carlos H.S.
; Flechtmann, Carlos H.W.
; Lamas, Carlos J.E.
; Rocha, Carlos
; Mascarenhas, Carolina S.
; Margaría, Cecilia B.
; Waichert, Cecilia
; Digiani, Celina
; Haddad, Célio F.B.
; Azevedo, Celso O.
; Benetti, Cesar J.
; Santos, Charles M.D. dos
; Bartlett, Charles R.
; Bonvicino, Cibele
; Ribeiro-Costa, Cibele S.
; Santos, Cinthya S.G.
; Justino, Cíntia E.L.
; Canedo, Clarissa
; Bonecker, Claudia C.
; Santos, Cláudia P.
; Carvalho, Claudio J.B. de
; Gonçalves, Clayton C.
; Galvão, Cleber
; Costa, Cleide
; Oliveira, Cléo D.C. de
; Schwertner, Cristiano F.
; Andrade, Cristiano L.
; Pereira, Cristiano M.
; Sampaio, Cristiano
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; Nishiyama, Eric Y.
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; Contreras, Eugenia F.
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; Machado, Fabrizio M.
; Barbo, Fausto E.
; Agrain, Federico A.
; Ribeiro, Felipe B.
; Moreira, Felipe F.F.
; Barbosa, Felipe F.
; Silva, Fenanda S.
; Cavalcanti, Fernanda F.
; Straube, Fernando C.
; Carbayo, Fernando
; Carvalho Filho, Fernando
; Zanella, Fernando C.V.
; Jacinavicius, Fernando de C.
; Farache, Fernando H.A.
; Leivas, Fernando
; Dias, Fernando M.S.
; Mantellato, Fernando
; Vaz-de-Mello, Fernando Z.
; Gudin, Filipe M.
; Albuquerque, Flávio
; Molina, Flavio B.
; Passos, Flávio D.
; Shockley, Floyd W.
; Pinheiro, Francielly F.
; Mello, Francisco de A.G. de
; Nascimento, Francisco E. de L.
; Franco, Francisco L.
; Oliveira, Francisco L. de
; Melo, Francisco T. de V.
; Quijano, Freddy R.B.
; Salles, Frederico F.
; Biffi, Gabriel
; Queiroz, Gabriel C.
; Bizarro, Gabriel L.
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; Arruda, Janine O.
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; Avendaño, Jose M.
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; Teixeira, Joyce A.
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; Mathis, Wayne N.
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; Colombo, Wesley D.
; Tomaszewska, Wioletta
; Wosiacki, Wolmar B.
; Ovando, Ximena M.C.
; Leite, Yuri L.R.
.
ABSTRACT The limited temporal completeness and taxonomic accuracy of species lists, made available in a traditional manner in scientific publications, has always represented a problem. These lists are invariably limited to a few taxonomic groups and do not represent up-to-date knowledge of all species and classifications. In this context, the Brazilian megadiverse fauna is no exception, and the Catálogo Taxonômico da Fauna do Brasil (CTFB) (http://fauna.jbrj.gov.br/), made public in 2015, represents a database on biodiversity anchored on a list of valid and expertly recognized scientific names of animals in Brazil. The CTFB is updated in near real time by a team of more than 800 specialists. By January 1, 2024, the CTFB compiled 133,691 nominal species, with 125,138 that were considered valid. Most of the valid species were arthropods (82.3%, with more than 102,000 species) and chordates (7.69%, with over 11,000 species). These taxa were followed by a cluster composed of Mollusca (3,567 species), Platyhelminthes (2,292 species), Annelida (1,833 species), and Nematoda (1,447 species). All remaining groups had less than 1,000 species reported in Brazil, with Cnidaria (831 species), Porifera (628 species), Rotifera (606 species), and Bryozoa (520 species) representing those with more than 500 species. Analysis of the CTFB database can facilitate and direct efforts towards the discovery of new species in Brazil, but it is also fundamental in providing the best available list of valid nominal species to users, including those in science, health, conservation efforts, and any initiative involving animals. The importance of the CTFB is evidenced by the elevated number of citations in the scientific literature in diverse areas of biology, law, anthropology, education, forensic science, and veterinary science, among others. publications problem uptodate up date classifications context exception (CTFB http//fauna.jbrj.gov.br/, httpfaunajbrjgovbr http //fauna.jbrj.gov.br/ , jbrj gov br (http://fauna.jbrj.gov.br/) 2015 Brazil 80 specialists 1 2024 133691 133 691 133,69 125138 125 138 125,13 82.3%, 823 82 3 (82.3% 102000 102 000 102,00 7.69%, 769 7 69 (7.69% 11000 11 11,00 . 3,567 3567 567 (3,56 2,292 2292 2 292 (2,29 1,833 1833 833 (1,83 1,447 1447 447 (1,44 1000 1,00 831 (83 628 (62 606 (60 520 (52 50 users science health biology law anthropology education others http//fauna.jbrj.gov.br/ faunajbrjgovbr //fauna.jbrj.gov.br (http://fauna.jbrj.gov.br/ 201 8 202 13369 13 133,6 12513 12 125,1 82.3% (82.3 10200 10 00 102,0 7.69% 76 6 (7.69 1100 11,0 3,56 356 56 (3,5 2,29 229 29 (2,2 1,83 183 83 (1,8 1,44 144 44 (1,4 100 1,0 (8 62 (6 60 52 (5 5 http//fauna.jbrj.gov.br (http://fauna.jbrj.gov.br 20 1336 133, 1251 125, 82.3 (82. 1020 0 102, 7.69 (7.6 110 11, 3,5 35 (3, 2,2 22 (2, 1,8 18 (1, 1,4 14 4 ( 82. (82 7.6 (7. 3, (3 2, (2 (1 7. (7
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