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au:Lima, Marjorie

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Brazilian Berry Extract Chemopreventive Action: Hormone Receptors as a Target to Mitigate Aging Prostatic Disorders.
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Longo, Marjorie Barcha

; Lamas, Celina de Almeida

; Rossetto, Isabela Urra

; Nogueira-Lima, Ellen

; Collares-Busatto, Carla Beatriz

; Maróstica Junior, Mário Roberto

; Quitete, Valéria Helena Alves Cagnon

Brazilian Archives of Biology and Technology

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2023, Volume 66 elocation e23220075

Abstract: En | Text: En | PDF: En

Abstract The Brazilian berry, also known as jaboticaba, has a great antioxidant and anti-inflammatory potential, besides demonstrating positive effects on hormonal regulation and weight loss. Nowadays, both aging and overweight are considered public health issues, promoting metabolic and hormonal changes that have a substantial role in prostate injury. We demonstrated herein that a low dose of jaboticaba peel extract (PJE) is enough to limit the onset of damages and hormone receptor alterations on the anterior prostate in the senile or high-fat diet (HFD) groups. The senile mice (11-months old) received the PJE and/or a HFD for 60 days. The anterior prostates were collected for histopathological, immunohistochemistry and western-blotting analysis. The PJE treatment reduced the epithelium atrophy and inflammatory infiltrate frequencies besides decreasing the androgen receptor (AR); estrogen receptor alpha (ERα); and insulin-like growth factor 1 receptor (IGFR-1) immunoexpression; in the anterior prostate of both senile and HFD-senile mice. However, low prostatic intraepithelial neoplasia (PIN) frequency, reduced immunoexpression of stromal AR and epithelium IGFR-1 were only observed in the anterior prostate of the PJE and HFD-treated groups. HFD intake intensified the aging-induced histopathological and hormonal alterations by further increasing the AR, ERα and IGFR-1 immunoexpression, as well as the PIN lesion incidence in the anterior prostate. Thus, the PJE was able to interfere in the hormonal signaling mediators, protecting the anterior prostate microenvironment and preventing lesion development due to aging associated or not with HFD intake.

https://doi.org/10.1590/1678-4324-2023220075

Impactos da pandemia do novo coronavírus no direito humano à alimentação e à nutrição adequadas e programas de segurança alimentar e nutricional: quais os desafios e o que propor?
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Bragança, Maylla Luanna Barbosa Martins

; Muniz, Alessandra Karla Oliveira Amorim

; Rudakoff, Lívia Carolina Sobrinho

; Vale, Marjorie Rafaela Lima do

Cadernos Saúde Coletiva

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2023, Volume 31 N. 3 elocation e31030261

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

Abstract Background The new coronavirus pandemic increased the violation of human rights to adequate food and nutrition and increased food and nutritional insecurity in the Brazilian population. Objective to analyze the policies and programs adopted by the Brazilian Government to promote food and nutritional security during the pandemic (year 2020). Method Official websites were searched to identify proposed initiatives. Results Despite some specific measures, such as emergency financial aid, more effective strategies to strengthen the Food Acquisition Program, encourage small farmers, facilitate food transportation and sale and to guarantee that assistance programs that facilitate income and food access are continued throughout the whole pandemic, need to be urgently considered. Conclusion Initiatives from the three spheres of government are required to combat the impacts of the new coronavirus pandemic on indices of food and nutritional insecurity in Brazil.

Resumo Introdução A pandemia do novo coronavírus intensificou a violação do direito humano à alimentação e nutrição adequadas e elevou a insegurança alimentar e nutricional na população brasileira. Objetivo Analisar as estratégias das políticas e programas de segurança alimentar e nutricional adotadas pelo governo brasileiro durante a pandemia (ano de 2020) para promoção da segurança alimentar e nutricional e combate à insegurança alimentar e nutricional no país. Método Realizou-se busca nos sites oficiais para análise das ações propostas. Resultados Apesar de algumas proposições pontuais, como a distribuição do auxílio emergencial, estratégias mais enérgicas, como o fortalecimento do Programa de Aquisição de Alimentos, encorajamento de pequenos agricultores, facilitação do transporte e da comercialização de alimentos e a garantia da continuidade de programas assistenciais que facilitem acesso à renda e à alimentação durante a pandemia, precisam ser urgentemente adotadas. Conclusão Essas estratégias requerem atuação das três esferas de governo em prol do combate dos impactos da pandemia do novo coronavírus nos índices de insegurança alimentar e nutricional no Brasil.

https://doi.org/10.1590/1414-462x202331030261

É ISTO UM ROMANCE?
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Santos, Carolina Barbosa Lima e

Ilha do Desterro

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aug 2022, Volume 75 N. 2 Pages 231 - 245

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Propomos, neste trabalho, uma análise de Eles eram muitos cavalos (2001/2006), do escritor contemporâneo brasileiro Luiz Ruffato. Procuramos problematizar a discussão sobre a possível configuração desta obra sob a forma, denominada pelo próprio autor, de uma “instalação literária”. Ao apresentar este modo de fazer literário, Ruffato propõe uma reflexão relacionada a diversas mazelas sociais brasileiras sob uma perspectiva crítica descentrada, afastada de qualquer viés ufanista. Herdeiro de poéticas modernas, como a mallarmeana e as vanguardistas europeias, o autor configura uma poética, estruturada em um mosaico de gêneros textuais, capaz de apreender e refratar a atmosfera de dinamicidade do mundo contemporâneo. Para desenvolvermos esta análise, atenta sobretudo às proposições estéticas da obra, recuperamos o conceito de instalação, utilizado nas Artes Visuais, bem como determinados textos teóricos voltados à análise da relação entre a literatura e outras linguagens, desenvolvidos por autoras como Marjorie Perloff, Márcia Arbex e Maria Adélia Menegazzo.

Abstract We propose, in this work, an analysis of Eles Eram Muitos Cavalos (2001/2006), by the contemporary Brazilian writer Luiz Ruffato. We try to problematize the possible configuration of the work as a “literary installation”, a term used by the author himself. By presenting this way of doing literary work, Ruffato proposes a reflection on Brazilian social ills from a decentered critical perspective, far from any nationalistic bias. Heir to modern poetics, such as Mallarmean and European avant-gardes, the author configures a poetics, structured in a mosaic of textual genres, capable of apprehending and refracting the dynamic atmosphere of the contemporary world. To develop this analysis, focused mainly on the work’s aesthetic propositions, we recovered the concept of installation, used in Visual Arts, as well as theoretical studies aimed at analyzing the relationship between literature and other arts, developed by authors such as Marjorie Perloff, Márcia Arbex, and Maria Adélia Menegazzo.

https://doi.org/10.5007/2175-8026.2022.e85699

Parámetros de corte en brocas genéricas para su aplicación en pequeñas y medianas empresas metalmecánicas del Ecuador
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Erazo-Arteaga, Victor A.

; Segovia, Marjorie P.

; Lima, Jonathan X.

; Mejía-Echeverría, Cosme D.

Información tecnológica

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dec 2021, Volume 32 N. 6 Pages 203 - 212

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

Abstract: The primary objective of this study is to optimize the lifetime of generic drilling tools used in micro, small, and medium-sized (MIPYME, in Spanish) metalworking companies in Ecuador. First, the preference of generic tools is assessed, the most widely accepted drills are acquired, and a set of cutting parameters is proposed. Then, tests are performed to measure flank wear and consumed power. Finally, tests are repeated to assess cutting conditions used by operators. The results show that generic drills have a composition similar to that of the JIS-SHK55 tool steel. It is concluded that by using the cutting parameters proposed here, drilling tool lifetime is increased, but with greater power consumption.

Resumen: El presente estudio tiene como objetivo optimizar la vida útil de herramientas genéricas de taladrado que se utilizan de forma empírica en micro, pequeñas y medianas empresas (MIPYME) metalmecánicas del Ecuador. Primero, se miden la preferencia de las herramientas genéricas, se adquieren las brocas de mayor aceptación y se propone un conjunto de parámetros de corte. Posteriormente, se realizan ensayos en los que se observa el desgaste de flanco y la potencia de corte consumida. Finalmente, se repite el ensayo para condiciones de corte generalmente utilizadas por los operadores. Los resultados muestran que las brocas genéricas presentan una composición semejante al acero de herramientas JIS-SHK55. Se concluye que con los parámetros de corte propuestos, la vida útil de las herramientas se alarga, pero presentan un mayor consumo de potencia.

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Evidências de validade da Escala de Segurança Alimentar e Nutricional para adolescentes (ESANa)
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Vale, Marjorie Rafaela Lima do

; Santos, Walberto Silva dos

; Pontes Junior, José Airton de Freitas

; Diniz, Renata Belizário

; Ávila, Maria Marlene Marques

Ciência & Saúde Coletiva

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jan 2021, Volume 26 N. 1 Pages 255 - 264

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo O objetivo do trabalho foi desenvolver uma escala válida e fidedigna para a avaliação de insegurança alimentar e nutricional especificamente em adolescentes. A versão inicial da escala foi composta por duas subescalas: percepção de insegurança alimentar e percepção de segurança nutricional. Os itens elaborados foram submetidos à análise de conteúdo por peritos em segurança alimentar e nutricional (n = 4) e à análise semântica por adolescentes selecionados por conveniência e oriundos da população alvo (n=20). Após ajustes, a versão final da escala foi aplicada junto a adolescentes escolares (n = 425) com idade entre 12 e 18 anos (m = 14,32±0,96; CV = 6,7%). Após realização de análise fatorial exploratória, um modelo de dois fatores foi o que se mostrou mais adequado. As subescalas avaliadas apresentaram valores modestos do coeficiente alfa (0,69 e 0,60, respectivamente). Consumo diário de frutas, verduras e refrigerantes se mostrou significativamente associado a escores mais elevados na escala de percepção de segurança alimentar e nutricional. Sugere-se a viabilidade de combinar itens com base no acesso a alimentos com outros relacionados a atitudes e práticas de alimentação saudável de modo a obter um retrato mais aproximado das necessidades dos adolescentes e melhor orientar políticas públicas.

Abstract This study aimed to develop a valid and reliable scale for assessing food and nutritional insecurity, specifically in adolescents. The initial version of the scale consisted of two subscales: perception of food insecurity and perception of nutritional security. The items were submitted to content analysis (n = 4) by a group of food and nutrition security experts, and semantic analysis (n = 20) by a group of adolescents conveniently sampled from the target population. After adjustments, the final version of the scale was applied to adolescent students (n = 425) aged 12 to 18 years (m = 14.32±0.96; CV = 6.7%). A two-factor model was the most appropriate after performing exploratory factor analysis. The subscales showed modest values of the alpha coefficient (0.69 and 0.60, respectively). Daily consumption of fruits, vegetables and soft drinks was significantly associated with higher scores in the food and nutrition security perception scale. Therefore, it is recommended to combine food access-based items with other aspects related to attitudes and behaviors towards healthy eating in order to achieve a more accurate picture of adolescent’s needs and better guide public policies.

https://doi.org/10.1590/1413-81232020261.35892018 986 downloads

Evidências de validade da Escala de Segurança Alimentar e Nutricional para adolescentes (ESANa)
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Vale, Marjorie Rafaela Lima do

; Santos, Walberto Silva dos

; Pontes Junior, José Airton de Freitas

; Diniz, Renata Belizário

; Ávila, Maria Marlene Marques

Ciência & Saúde Coletiva

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2021, Volume 26 N. 1 Pages 255 - 264

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

https://doi.org/10.1590/1413-81232020261.35892018

Use and misuse of biomarkers and the role of D-dimer and C-reactive protein in the management of COVID-19: A post-hoc analysis of a prospective cohort study
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Gonçalves, Fabio Augusto Rodrigues

; Besen, Bruno Adler Maccagnan Pinheiro

; Lima, Clarice Antunes de

; Corá, Aline Pivetta

; Pereira, Antônio José Rodrigues

; Perazzio, Sandro Félix

; Gouvea, Christiane Pereira

; Fonseca, Luiz Augusto Marcondes

; Trindade, Evelinda Marramon

; Sumita, Nairo Massakazu

; Duarte, Alberto José da Silva

; Lichtenstein, Arnaldo

; Bonfa, Eloisa

; Utiyama, Edivaldo M.

; Segurado, Aluisio C.

; Perondi, Beatriz

; Miethke-Morais, Anna

; Montal, Amanda C.

; Harima, Leila

; Fusco, Solange R. G.

; Silva, Marjorie F.

; Rocha, Marcelo C.

; Marcilio, Izabel

; Rios, Izabel Cristina

; Kawano, Fabiane Yumi Ogihara

; Jesus, Maria Amélia de

; Kallas, Ésper George

; Carmo, Carolina

; Tanaka, Clarice

; Souza, Heraldo Possolo de

; Marchini, Julio F. M.

; Carvalho, Carlos

; Ferreira, Juliana C.

; Levin, Anna Sara Shafferman

; Oliveira, Maura Salaroli

; Guimarães, Thaís

; Lázari, Carolina dos Santos

; Sabino, Ester

; Magri, Marcello M. C.

; Barros-Filho, Tarcisio E. P.

; Francisco, Maria Cristina Peres Braido

; Costa, Silvia F.

Clinics

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2021, Volume 76 elocation e3547

Abstract: En | Text: En | PDF: En

OBJECTIVE: Coronavirus disease 2019 (COVID-19) is associated with high mortality among hospitalized patients and incurs high costs. Severe acute respiratory syndrome coronavirus 2 infection can trigger both inflammatory and thrombotic processes, and these complications can lead to a poorer prognosis. This study aimed to evaluate the association and temporal trends of D-dimer and C-reactive protein (CRP) levels with the incidence of venous thromboembolism (VTE), hospital mortality, and costs among inpatients with COVID-19. METHODS: Data were extracted from electronic patient records and laboratory databases. Crude and adjusted associations for age, sex, number of comorbidities, Sequential Organ Failure Assessment score at admission, and D-dimer or CRP logistic regression models were used to evaluate associations. RESULTS: Between March and June 2020, COVID-19 was documented in 3,254 inpatients. The D-dimer level ≥4,000 ng/mL fibrinogen equivalent unit (FEU) mortality odds ratio (OR) was 4.48 (adjusted OR: 1.97). The CRP level ≥220 mg/dL OR for death was 7.73 (adjusted OR: 3.93). The D-dimer level ≥4,000 ng/mL FEU VTE OR was 3.96 (adjusted OR: 3.26). The CRP level ≥220 mg/dL OR for VTE was 2.71 (adjusted OR: 1.92). All these analyses were statistically significant (p<0.001). Stratified hospital costs demonstrated a dose-response pattern. Adjusted D-dimer and CRP levels were associated with higher mortality and doubled hospital costs. In the first week, elevated D-dimer levels predicted VTE occurrence and systemic inflammatory harm, while CRP was a hospital mortality predictor. CONCLUSION: D-dimer and CRP levels were associated with higher hospital mortality and a higher incidence of VTE. D-dimer was more strongly associated with VTE, although its discriminative ability was poor, while CRP was a stronger predictor of hospital mortality. Their use outside the usual indications should not be modified and should be discouraged.

https://doi.org/10.6061/clinics/2021/e3547

Desafios das práticas arqueológicas e da preservação: dinâmicas socioculturais sobre e nos entornos dos sítios arqueológicos na Amazônia
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Lima, Marjorie

; Silva, Maurício André da

; Lima, Silvia Cunha

; Cassino, Mariana Franco

; Tamanaha, Eduardo

Boletim do Museu Paraense Emílio Goeldi. Ciências Humanas

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2021, Volume 16 N. 2 elocation e20190153

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo As relações das pessoas com as coisas e os sítios arqueológicos no contexto amazônico é extremamente plural e contextual. A cada comunidade, pesquisadores e pesquisadoras aprendem outras formas de pensar as intrínsecas relações entre passado e presente. O Laboratório de Arqueologia do Instituto de Desenvolvimento Sustentável Mamirauá tem primado por uma atuação interdisciplinar para o desenvolvimento de ações e pesquisas com as comunidades ribeirinhas nas áreas de proteção. Neste artigo, abordamos as práticas arqueológicas e a salvaguarda do patrimônio em contextos comunitários. Por meio da arqueologia, da conservação arqueológica e da educação, refletimos sobre nosso papel como profissionais que atuam a partir de diferentes saberes e grupos de interesse, onde valores, significados e resultados são revisitados a todo momento em que novas colaborações são estabelecidas, seja entre pesquisas acadêmicas, seja entre agentes da comunidade. Para isso, discute-se os trabalhos desenvolvidos em Boa Esperança, localizada na Reserva de Desenvolvimento Sustentável (RDS) Amanã, que recebe arqueólogos e arqueólogas desde 2006. Consideramos que a pesquisa se transformou pelo contexto comunitário e pela ampliação do envolvimento de diferentes agentes, reorientando nossas ações em busca de alternativas de médio e longo prazo para a gestão colaborativa e sustentável do patrimônio arqueológico amazônico.

Abstract People’s relationships with things and with archaeological sites in the Amazonian context are extremely plural and contextual. In each community, researchers learn other ways of thinking about the intrinsic relationships between the past and present. The Mamirauá Institute’s Archaeology Laboratory has excelled at an interdisciplinary approach to developing activities and research together with riverine communities in protected areas. In this article, we discuss archaeological practices and the challenges of preserving archaeological heritage in community contexts. Through archaeology, archaeological conservation, and education, we reflect on our role as professionals working from different knowledge and interest groups, where values, meanings, and results are revisited every time new collaborations are established (whether these involve academic research or community agents). To do so, we examine the work carried out in the Boa Esperança community, located in the Amanã Sustainable Development Reserve, which has been receiving archaeologists since 2006. This research is considered to have been transformed by the community context and by broader engagement with different agents, reorienting efforts to find medium- and long-term alternatives for collaborative and sustainable management of the Amazon’s archaeological heritage.

https://doi.org/10.1590/2178-2547-bgoeldi-2019-0153 286 downloads

Antibacterial, antifungal, and antiviral activities of chalcone-bearing tetrahydropyranyl and 2,4-dihydroxyl moieties
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Lima, William Gustavo

; Tauany Andrade, Jéssica

; Rocha da Silva Santos, Felipe

; Campos Palumbo, Juliana Maria

; Silva Herrera, Karina Marjorie

; de Castro, Laurieny Eloína

; de Morais, Fernanda Bárbara

; Prates da Silva, Mayra Karla

; Ferreira Perez Villar, José Augusto

; Siqueira Ferreira, Jaqueline Maria

Revista Colombiana de Ciencias Químico - Farmacéuticas

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apr 2020, Volume 49 N. 1 Pages 218 - 233

Abstract: Es En Pt | Text: Es En Pt | PDF: Es | PDF: En | PDF: Pt

RESUMEN Las chalconas se destacan como una estructura importante en la química médica y, por lo tanto, se ha empleado como prototipo para el desarrollo de nuevos fármacos. En este estudio, nuestro objetivo fue determinar el potencial antibacteriano, anti Candida y anti-Dengue de las nuevas chalconas que poseen los grupos 2,4-dihidroxilo y tetrahidropiranilo. El ensayo de actividad antimicrobiana mostró que las bacterias del género Staphylococcus (incluidas las cepas resistentes a la meticilina) fueron sensibles a las 2,4-dihidroxicalconas estudiadas, con concentraciones inhibitorias mínimas (CIM) que oscilan entre 19,5 y 125 µg.mL-1. El compuesto 4e, que tuvo el mejor efecto bacteriostático, también mostró un efecto bactericida a partir de la concentración de 80 µg.mL-1. El crecimiento de los aislamientos orales de Candida albicans también se inhibió eficientemente con el compuesto 4e (CIM: 15.6-32.3 µg.mL-1), que fue fungicida a una concentración de 15.6 µg.mL-1. Sin embargo, la presencia del grupo tetrahidropiranilo perjudicó la actividad antibacteriana y anti-fúngica de los análogos de la chalcona. Además, ninguno de los compuestos evaluados mostró un efecto contra el virus del dengue serotipo 2. En conclusión, el compuesto 4e muestra una buena actividad anti-estafilocócica y anti-Candida y puede ser un prototipo prometedor para el desarrollo de nuevos agentes antimicrobianos.

SUMMARY Chalcones highlights as an important structure in medicinal chemistry and thus has been widely used as a template in the development of new drugs. In this study, we aim to determine the antibacterial, anti-Candida, and anti-Dengue potential of new chalcone-bearing 2,4-dihydroxyl and tetrahydropyranyl moieties. Antimicrobial activity assays showed that microorganism of the Staphylococcus genus (including methicillin-resistant strains) were susceptible to 2,4-dihydroxychalcones, with minimum inhibitory concentrations (MICs) ranging of 19.5 to 125 µg.mL-1. Compound 4e, which showed the highest bacteriostatic effect, also has bactericidal activity from of 80 µg.mL-1. The growth of oral isolates of Candida albicans was also efficiently inhibited with compound 4e (MIC: 15.6-32.3 µg.mL-1), which was fungicidal at 15.6 µg.mL-1. However, the presence of the tetrahydropyranyl moiety impaired both the antibacterial and antifungal effects. None of the chalcones tested were actives against Dengue virus serotype 2. In conclusion, the compound 4e showed good anti-Staphylococci and anti-Candida activity and may be a promising prototype for the development of new antimicrobial agents.

RESUMO As chalconas se destacam como uma importante estrutura na química medicinal e dessa forma tem sido empregada como um protótipo para o desenvolvimento de novos fármacos. Nesse estudo, nós objetivamos determinar o potencial antibacteriano, anti-Candida, e anti-Dengue de novas chalconas que possuem os grupos 2,4-dihidroxil e tetrahidropiranil. O ensaio de atividade antimicrobiana mostrou que bactérias do gênero Staphylococcus (incluindo linhagens resistentes a meticilina) foram sensíveis para as 2,4-dihidroxichalconas estudadas, com concentrações inibitórias mínimas (CIM) variando de 19,5 para 125 Dengue potential of new chalcone µg.mL-1. O composto 4e, o qual apresentou o melhor efeito bacteriostático, também mostrou efeito bactericida a partir da concentração de 80 µg.mL-1. O crescimento de isolados orais de Candida albicans foi também eficientemente inibido com o composto 4e (CIM: 15.6-32.3 µg.mL-1), o qual foi fungicida a concentração de 15,6 µg.mL-1. Entretanto, a presença do grupo tetrahidropiranil prejudicou a atividade antibacteriana e antifúngica dos análogos de chalcona. Adicionalmente, nenhum dos compostos avaliados mostrou efeito contra o vírus da dengue sorotipo 2. Em conclusão, o composto 4e apresenta boa atividade anti-estafilocóccica e anti-Candida, e pode ser um promissor protótipo para o desenvolvimento de novos agentes antimicrobianos.

https://doi.org/10.15446/rcciquifa.v49n1.87036 345 downloads

10.

Clinical and microbiological characteristics of patients colonized or infected by Stenotrophomonas maltophilia: is resistance to sulfamethoxazole/trimethoprim a problem?
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Mendes, Elisa Teixeira

; Paez, Jorge Isaac Garcia

; Ferraz, Juliana Rosa

; Marchi, Ana Paula

; Silva, Ivan Leonardo Avelino França e

; Batista, Marjorie Vieira

; Lima, Ana Lucia Munhoz de

; Rossi, Flávia

; Levin, Anna Sara

; Costa, Silvia Figueiredo

Revista do Instituto de Medicina Tropical de São Paulo

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2020, Volume 62 elocation e96

Abstract: En | Text: En | PDF: En

ABSTRACT Stenotrophomonas maltophilia has emerged as an important opportunistic pathogen in the last decade. Increased resistance to sulfamethoxazole/trimethoprim (SMX/TMP) has been reported in S. maltophilia strains in the past few years, leading to few therapeutic options. We conducted a prospective multicenter study at two Brazilian teaching hospitals that identified S. maltophilia isolates and evaluated their antimicrobial susceptibility profile, SMX/TMP resistance genes and their clonality profile. A total of 106 non-repeated clinical samples of S. maltophilia were evaluated. Resistance to SMX/TMP was identified in 21.6% of the samples, and previous use of SMX/TMP occurred in 19 (82.6%). PCR detected the sul1 gene in 14 of 106 strains (13.2%). Of these isolates, nine displayed resistance to SMX/TMP. The resistant strains presented a polyclonal profile. This opportunistic pathogen has emerged in immunocompromised hosts, with few therapeutic options, which is aggravated by the description of emerging resistance mechanisms, although with a polyclonal distribution profile.

https://doi.org/10.1590/s1678-9946202062096 518 downloads

11.

Fibrin biopolymer as scaffold candidate to treat bone defects in rats
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Cassaro, Claudia Vilalva

; Justulin Jr., Luis Antonio

; Lima, Patrícia Rodrigues de

; Golim, Marjorie de Assis

; Biscola, Natália Perussi

; Castro, Mateus Vidigal de

; Oliveira, Alexandre Leite Rodrigues de

; Doiche, Danuta Pulz

; Pereira, Elenize Jamas

; Ferreira Jr., Rui Seabra

; Barraviera, Benedito

Journal of Venomous Animals and Toxins including Tropical Diseases

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2019, Volume 25 elocation e20190027

Abstract: En | Text: En | PDF: En

ABSTRACT Background: Bone tissue repair remains a challenge in tissue engineering. Currently, new materials are being applied and often integrated with live cells and biological scaffolds. The fibrin biopolymer (FBP) proposed in this study has hemostatic, sealant, adhesive, scaffolding and drug-delivery properties. The regenerative potential of an association of FBP, biphasic calcium phosphate (BCP) and mesenchymal stem cells (MSCs) was evaluated in defects of rat femurs. Methods: Adult male Wistar rats were submitted to a 5-mm defect in the femur. This was filled with the following materials and/or associations: BPC; FBP and BCP; FBP and MSCs; and BCP, FBP and MSCs. Bone defect without filling was defined as the control group. Thirty and sixty days after the procedure, animals were euthanatized and subjected to computed tomography, scanning electron microscopy and qualitative and quantitative histological analysis. Results: It was shown that FBP is a suitable scaffold for bone defects due to the formation of a stable clot that facilitates the handling and optimizes the surgical procedures, allowing also cell adhesion and proliferation. The association between the materials was biocompatible. Progressive deposition of bone matrix was higher in the group treated with FBP and MSCs. Differentiation of mesenchymal stem cells into osteogenic lineage was not necessary to stimulate bone formation. Conclusions: FBP proved to be an excellent scaffold candidate for bone repair therapies due to application ease and biocompatibility with synthetic calcium-based materials. The satisfactory results obtained by the association of FBP with MSCs may provide a more effective and less costly new approach for bone tissue engineering.

https://doi.org/10.1590/1678-9199-jvatitd-2019-0027 1596 downloads

12.

Survey of social wasps (Hymenoptera, Vespidae, Polistinae) in Amazon rainforest fragments in Acre, Brazil
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GOMES, Bruno

; KNIDEL, Samilla Vanessa de Lima

; MORAES, Heroílson da Silva

; SILVA, Marjorie da

Acta Amazonica

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apr 2018, Volume 48 N. 2 Pages 109 - 116

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO O estado do Acre é parte da Amazônia Ocidental brasileira, uma área que abriga uma grande biodiversidade e alto grau de endemismos. Contudo, poucos estudos investigaram a diversidade de vespas sociais nesta região. Este trabalho apresenta os resultados de uma amostragem de vespas sociais (Hymenoptera,Vespidae, Polistinae) em três fragmentos de floresta primária no estado do Acre. As vespas foram coletadas ativamente com o uso de solução atrativa. Um total de 758 vespas, pertencentes a 11 gêneros e 36 espécies, foi amostrado, sendo 19 dessas espécies novos registros de distribuição para o Acre e três novos registros para o Brasil. Nossos resultados indicam que novas investigações devem levar a um aumento significativo da diversidade de espécies de vespas Polistinae conhecida para a região. Nosso estudo produziu subsídios de grande utilidade para estudos biogeográficos e fornece informações importantes para a tomada de decisões sobre o manejo de áreas naturais.

ABSTRACT The State of Acre, in the southwestern Brazilian Amazon, harbors high biodiversity and a high degree of endemisms. Nevertheless, there are few studies on the diversity of social wasps occurring in this region. This study presents a list of social wasps (Hymenoptera, Vespidae, Polistinae) collected actively with attractive bait in three rainforest fragments in Acre. A total of 758 wasps belonging to 11 genera and 36 species were collected. Nineteen species were new distribution records for Acre and three others were new records for Brazil. Based on our results, further investigations should lead to a significant increase in Polistinae diversity in this region, producing information for biogeographic studies and management of natural areas.

https://doi.org/10.1590/1809-4392201700913 1553 downloads

13.

Sugarcane bagasse as only roughage for crossbred lactating cows in semiarid regions
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Freitas, Wandemberg Rocha

; Ferreira, Marcelo de Andrade

; Silva, Janaina Lima

; Véras, Antônia Sherlânea Chaves

; Barros, Leonardo José Assis

; Alves, Adryanne Marjorie Souza Vitor

; Chagas, Juana Catarina Cariri

; Siqueira, Thamires Damascena Quirino

; Almeida, Gleidiana Amélia Pontes de

Pesquisa Agropecuária Brasileira

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mar 2018, Volume 53 N. 3 Pages 386 - 393

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo: O objetivo deste trabalho foi avaliar o efeito de diferentes níveis de bagaço de cana-de-açúcar, como volumoso exclusivo, sobre consumo e digestibilidade de nutrientes, comportamento ingestivo, síntese de proteína microbiana e desempenho leiteiro de vacas mestiças. Dez vacas da raça Girolando (600±34,3 kg de peso corporal) foram distribuídas em delineamento de quadrado latino duplo 5×5. A dieta controle, baseada em palma forrageira, bagaço de cana-de-açúcar e concentrado, foi formulada para atender a média de produção de 20 kg de leite por dia, com 3,5% de gordura. Foram avaliados os seguintes níveis de bagaço de cana-de-açúcar: 30, 38, 46 e 54% da matéria seca. O consumo e a digestibilidade de matéria seca diminuíram linearmente com os níveis de bagaço. O tempo de ruminação foi maior para vacas alimentadas com 54% de bagaço. Os níveis de inclusão não tiveram efeito sobre o conteúdo de ácidos graxos não esterificados ou sobre a síntese de proteína microbiana, mas as concentrações de β-hidroxibutirato apresentaram comportamento quadrático com os níveis de bagaço. Maiores produções de leite corrigido a 3,5% de gordura foram obtidas com vacas alimentadas com 30% de bagaço. A inclusão do bagaço de cana-de-açúcar na dieta de vacas mestiças reduz seu desempenho; contudo, o bagaço pode ser utilizado como volumoso exclusivo quando associado a 70% de concentrado.

Abstract: The objective of this work was to evaluate the effects of different levels of sugarcane bagasse, as exclusive roughage, on nutrient intake and digestibility, feeding behavior, microbial protein synthesis, and dairy performance of crossbred cows. Ten lactating Girolando breed cows (600±34.3 kg body weight) were assigned to a replicated 5×5 Latin square design. The control diet, based on spineless cactus, sugarcane bagasse, and concentrate, was formulated to meet the average production of 20 kg of milk per day, with 3.5% fat. The evaluated levels of sugarcane bagasse were: 30, 38, 46, and 54% dry matter bases. The intake and digestibility of dry matter decreased linearly with sugarcane bagasse levels. Rumination time was higher in cows fed 54% sugarcane bagasse. The inclusion levels had no effect on non-esterified fatty acid contents or on the efficiency of microbial protein synthesis, but beta-hydroxybutyrate concentrations showed a quadratic pattern to the bagasse levels. Higher yields of 3.5% fat-corrected milk were obtained with cows fed 30% sugarcane bagasse. Sugarcane bagasse inclusion in the diet of crossbred dairy cows decreases their performance; however, the bagasse can be used as exclusive roughage when associated with 70% concentrate.

https://doi.org/10.1590/s0100-204x2018000300014 1242 downloads

14.

AVALIAÇÃO DA SATISFAÇÃO DE FAMILIARES DE PACIENTES ATENDIDOS EM UNIDADES DE TERAPIA INTENSIVA: REVISÃO INTEGRATIVA
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Neves, Josiele de Lima

; Schwartz, Eda

; Guanilo, Maria Elena Echevarria

; Amestoy, Simone Coelho

; Mendieta, Marjoriê da Costa

; Lise, Fernanda

Texto & Contexto - Enfermagem

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2018, Volume 27 N. 2 elocation e1800016

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

RESUMO Objetivo: analisar a produção científica relacionada às evidências acerca da satisfação de familiares de pacientes de UTI e os instrumentos utilizados para sua avaliação. Metodo: revisão integrativa na qual foram analisados artigos publicados entre 2005 e 2015, em inglês, português ou espanhol, nas bases de dados PUBMED/MEDLINE e LILACS e a biblioteca SciELO. Utilizou-se como estratégia de busca: personal satisfactional OR satisfaction AND family. Para coleta de dados dos artigos elaborou-se um instrumento com informações como: título, autores, ano de publicação e revista, objetivo do estudo, delineamento, participantes, local da pesquisa, temática principal e resultados. Resultados: atenderam aos critérios de inclusão 27 produções. Foram identificados quatro instrumentos utilizados para avaliar a satisfação de familiares de pacientes na UTI o Critical Care Family Satisfaction Survey, Family Satisfaction in the Intensive Care Unit, Critical Care Family Needs Inventory e o Quality of Dying and Death. Os estudos abordaram a satisfação dos familiares em relação às suas necessidades e tomadas de decisão, satisfação quanto a cuidados paliativos, evidenciou-se, ainda, estudos de adaptação transcultural e validação de instrumentos. Quanto ao nível de evidência, os estudos se concentram nos níveis II a VI. Conclusão: a análise da produção científica sobre a satisfação de familiares de pacientes de UTI permitiu evidenciar que o fator que mais contribui na promoção da satisfação da família foi a qualidade do atendimento.

ABSTRACT Objective: to analyze the scientific production related to the evidence on the satisfaction of family members of ICU patients and the instruments used for the evaluation. Method: An integrative review in which articles published between 2005 and 2015 were analyzed in English, Portuguese or Spanish, in the PUBMED / MEDLINE and LILACS databases and the SciELO library. The following were used as a search strategy: personal satisfaction OR satisfaction AND family. For the purpose of the data collection of articles, an instrument was developed with information such as title, authors, year of publication and journal, study objective, design, participants, research site, main theme and results. Results: 27 studies met the inclusion criteria. Four instruments were used to evaluate the satisfaction of family members of ICU patients: Critical Care Family Satisfaction Survey, Family Satisfaction in the Intensive Care Unit, Critical Care Family Needs Inventory and the Quality of Dying and Death. The studies addressed the satisfaction of family members in relation to their needs and decision making, satisfaction with palliative care, and cross-cultural adaptation studies and the validation of instruments were also evidenced. Regarding the level of evidence, the studies focus on levels II to VI. Conclusion: the analysis of the scientific production on the satisfaction of family members of ICU patients showed that the factor that contributes most to the promotion of family satisfaction was the quality of care.

RESUMEN Objetivo: analizar la producción científica relacionada con las evidencias acerca de la satisfacción de familiares de pacientes de UTI y los instrumentos utilizados para su evaluación. Método: revisión integradora en la que se analizaron artículos publicados entre el 2005 y el 2015 en inglés, portugués o español, en las bases de datos PUBMED/MEDLINE, LILACS y la biblioteca SciELO. Se utilizó como estrategia de búsqueda: personal satisfactional OR satisfaction AND family. Para la recoleccion de datos de los artículos se elaboró un instrumento con informaciones tales como título, autores, año de publicación y revista, objetivo del estudio, delineamiento, participantes, lugar de investigación, temática principal y resultados. Resultados: 27 producciones atendieron los criterios de inclusión. Fueron identificados cuatro instrumentos utilizados para evaluar la satisfacción de familiares de pacientes en la UTI o el Critical Care Family Satisfaction Survey, Family Satisfaction in the Intensive Care Unit, Critical Care Family Needs Inventory y el Quality of Dying and Death. Los estudios abordaron la satisfacción de los familiares en relación a sus necesidades y la toma de decisiones, satisfacción sobre los cuidados paliativos. Además, se evidenciaron los estudios de adaptación transcultural y la validación de los instrumentos. Sobre el nivel de evidencia, los estudios se concentran en los niveles II a VI. Conclusión: el análisis de la producción científica sobre la satisfacción de los familiares de pacientes de UTI permitió evidenciar que el factor que más contribuye en la promoción de la satisfacción de la familia fue la cualidad del atendimiento.

https://doi.org/10.1590/0104-070720180001800016 4405 downloads

15.

AVALIAÇÃO DA SATISFAÇÃO DE FAMILIARES DE PACIENTES ATENDIDOS EM UNIDADES DE TERAPIA INTENSIVA: REVISÃO INTEGRATIVA
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Neves, Josiele de Lima

; Schwartz, Eda

; Guanilo, Maria Elena Echevarria

; Amestoy, Simone Coelho

; Mendieta, Marjoriê da Costa

; Lise, Fernanda

Texto & Contexto - Enfermagem

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2018, Volume 27 N. 2 elocation e1800016

Abstract: En Es Pt | Text: En Es Pt | PDF: En | PDF: Es | PDF: Pt

https://doi.org/10.1590/0104-070720180001800016 94 downloads

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