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ABSTRACT Objective: This study aimed to translate, and perform a cross-cultural adaptation, and validation of the Vancouver Symptom Score (VSS) for bladder and bowel dysfunction (BBD) for Brazilian children and adolescents Materials and Methods: Six steps were performed for the translation and cross-cultural adaptation: (1) translation, (2) synthesis of translations, (3) back-translation, (4) pre-final version of the translated instrument, (5) pilot test and degree of comprehensibility and (6) elaboration of the Brazilian version of the VSS. For validation, the Brazilian Dysfunctional Voiding Score (DVSS) questionnaire was used. Results: Validation was performed on a sample of 107 children and adolescents with a mean age of 9.2 ± 2.84 years, presenting BBD and 107 without BBD (control group-CG). There was a positive correlation (r = 0.91, 95% CI 0.88 to 0.93, p < 0.0001) between total VSS score and total DVSS score. VSS was higher in patients with BBD (p < 0.0001). The internal consistency estimated by Cronbach's alpha was 0.87 for patients with BBD. The VSS showed excellent diagnostic accuracy in detecting cases, with an area under the ROC curve of 98% (95% CI 0.96 to 0.99, p < 0.001). A cut-off value of >11 points produced a sensitivity of 100% (95% CI 96.4% to 100%) and a specificity of 91.8% (95% CI 85.1% to 95.6%). Conclusion: The translated, cross-culturally adapted, and validated VSS for the Brazilian population is a reliable and valid tool to identify symptoms of BBD in children and adolescents aged five to 16 years, whose first language is Brazilian Portuguese.

https://doi.org/10.1590/s1677-5538.ibju.2022.0495

Visceral adiposity indices and cardiometabolic risk markers in patients with hypertension
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Sena, Berilany dos Santos

; Gonçalves, Fabiana Cristina Lima da Silva Pastich

; Maio, Regiane

; Silva, Rebecca Peixoto Paes

; Lemos, Maria da Conceição Chaves de

; Arruda, Ilma Kruze Grande de

Archives of Endocrinology and Metabolism

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2023, Volume 67 N. 2 Pages 224 - 232

Abstract: En | Text: En | PDF: En

Abstract Objective: Arterial hypertension (AH) is a risk factor for cardiovascular diseases (CVD). We sought to evaluate the association between two adiposity indices (visceral adiposity index [VAI] and lipid accumulation product [LAP]) with traditional markers of cardiometabolic risk in hypertensive patients. Materials and methods: This is a cross-sectional study with 1,273 subjects with hypertension treated as outpatients at a university hospital. The VAI and LAP were calculated using formulas stratified by sex. Cardiometabolic risk variables were considered: overweight, risk for waist circumference (WC), waist-to-hip ratio (WHR), waist-to-height ratio (WHA), and altered biochemical test values. The predictive effect of independent variables on outcomes was assessed by multivariate linear regression analysis. There was statistical significance when p ≤ 0.05. Results: Higher cardiometabolic risk (according to BMI, WHR, WHA, and altered biochemical parameters) was associated with higher values of VAI and LAP with statistical significance (p ≤ 0.05). The regression models used explained 30.7% and 10.5% of the changes in LAP and VAI, respectively. Conclusion: LAP and VAI are associated with cardiometabolic risk parameters in the individuals evaluated, suggesting that these indices can be used to screen for CVD risk in individuals with AH.

https://doi.org/10.20945/2359-3997000000536

Influência do Exercício Físico sobre a Mecânica de Contração do Ventrículo Esquerdo após Infarto do Miocárdio
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Lima, Márcio Silva Miguel

; Dalçóquio, Talia Falcão

; Abduch, Maria Cristina Donadio

; Tsutsui, Jeane Mike

; Mathias Jr, Wilson

; Nicolau, José Carlos

Arquivos Brasileiros de Cardiologia

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2023, Volume 120 N. 4 elocation e20220185

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

Abstract Background Exercise plays a positive role in the course of the ischemic heart disease, enhancing functional capacity and preventing ventricular remodeling. Objective To investigate the impact of exercise on left ventricular (LV) contraction mechanics after an uncomplicated acute myocardial infarction (AMI). Methods A total of 53 patients was included, 27 of whom were randomized to a supervised training program (TRAINING group), and 26 to a CONTROL group, who received usual recommendations on physical exercise after AMI. All patients underwent cardiopulmonary stress testing and a speckle tracking echocardiography to measure several parameters of LV contraction mechanics at one month and five months after AMI. A p value < 0.05 was considered statistically significant for the comparisons of the variables. Results No significant difference were found in the analysis of LV longitudinal, radial and circumferential strain parameters between groups after the training period. After the training program, analysis of torsional mechanics demonstrated a reduction in the LV basal rotation in the TRAINING group in comparison to the CONTROL group (5.9±2.3 vs. 7.5±2.9o; p=0.03), and in the basal rotational velocity (53.6±18.4 vs.68.8±22.1 º/s; p=0.01), twist velocity (127.4±32.2 vs. 149.9±35.9 º/s; p=0.02) and torsion (2.4±0.4 vs. 2.8±0.8 º/cm; p=0.02). Conclusions Physical activity did not cause a significant improvement in LV longitudinal, radial and circumferential deformation parameters. However, the exercise had a significant impact on the LV torsional mechanics, consisting of a reduction in basal rotation, twist velocity, torsion and torsional velocity which can be interpreted as a ventricular “torsion reserve” in this population.

Resumo Fundamento O exercício exerce um papel positivo na evolução da doença cardíaca isquêmica, melhorando a capacidade funcional e prevenindo o remodelamento ventricular. Objetivo Investigar o impacto do exercício sobre a mecânica de contração do ventrículo esquerdo (VE) após um infarto agudo do miocárdio (IAM) não complicado. Métodos Um total de 53 pacientes foram incluídos e alocados aleatoriamente em um programa de treinamento supervisionado (grupo TREINO, n=27) ou em um grupo CONTROLE (n=26) que recebeu recomendações usuais sobre a prática de exercício físico após um IAM. Todos os pacientes realizaram um teste cardiopulmonar e um ecocardiograma com speckle tracking para medir vários parâmetros da mecânica de contração do VE em um mês e cinco meses após o IAM. Um valor de p <0,05 foi considerado para significância estatística nas comparações das variáveis. Resultados Não foram encontradas diferenças nas análises dos parâmetros de strain circunferencial, radial ou longitudinal do VE entre os grupos após o período de treinamento. Após o programa, a análise da mecânica de torção revelou uma redução na rotação basal do VE no grupo TREINO em comparação ao grupo CONTROLE (5,9±2,3 vs. 7,5±2.9o; p=0,03), bem como na velocidade rotacional basal (53,6±18,4 vs. 68,8± 22,1 º/s; p=0,01), velocidade de twist (127,4±32,2 vs. 149,9±35,9 º/s; p=0,02) e na torção (2,4±0,4 vs. 2,8±0, º/cm; p=0,02). Conclusões A atividade física não causou melhora significativa nos parâmetros de deformação longitudinal, radial ou circunferencial do VE. No entanto, o exercício teve um impacto significativo sobre a mecânica de torção do VE, que consistiu em uma redução na rotação basal, na velocidade de twist, na torção, e na velocidade de torção, que pode ser interpretada como uma “reserva” de torção ventricular nessa população.

https://doi.org/10.36660/abc.20220185

High and low-fidelity simulation for respiratory diseases pediatric training: a prospective and randomized study
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Valente, Beatriz Cristina Heitmann Gomes

; Melo, Maria do Carmo Barros de

; Liu, Priscila Menezes Ferri

; Gonçalves, Beatriz Adriane Rodrigues

; Gomes, Romina Aparecida dos Santos

; Martins, Isadora Guimarães

; Oliveira, Ana Clara Pereira Lage de

; Ferreira, Ana Luísa de Cássia Magalhães

; Bothrel, Rafaella Garcia

; Lasmar, Laura Maria de Lima Belizário Facury

Jornal de Pediatria

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2023, Volume 99 N. 5 Pages 521 - 528

Abstract: En | Text: En | PDF: En

Abstract Objective: To compare high and low-fidelity simulations for the recognition of respiratory distress and failure in urgency and emergency pediatric scenarios. Methods: 70 fourth-year medical students were randomly distributed in high and low-fidelity groups and simulated different types of respiratory problems. Theory tests, performance checklists, and satisfaction and self-confidence questionnaires were used in the assessment. Face-to-face simulation and memory retention was applied. The statistics were evaluated by averages and quartiles, Kappa, and generalized estimating equations. The p-value was considered 0.05. Results: In the theory test there was an increase in scores in both methodologies (p < 0.001 ); in memory retention (p = 0.043) and at the end of the process the high-fidelity group had better results. The performance in the practical checklists was better after the second simulation (p > 0,05). The high-fidelity group felt more challenged in both phases (p = 0.042; p = 0.018) and showed greater self-confidence to recognize changes in clinical conditions and in memory retention (p = 0.050). The same group, in relation to the hypothetical real patient to be treated in the future, felt better confident to recognize respiratory distress and failure (p = 0.008; p = 0.004), and better prepared to make a systematic clinical evaluation of the patient in memory retention (p = 0.016). Conclusion: The two levels of simulations enhance diagnostic skills. High fidelity improves knowledge, leads the student to feel more challenged and more self-confident in recognizing the severity of the clinical case, including memory retention, and showed benefits regarding self-confidence in recognizing respiratory distress and failure in pediatric cases.

https://doi.org/10.1016/j.jped.2023.04.007

Burnout, COVID-19, apoio social e insegurança alimentar em trabalhadores da saúde
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Colichi, Rosana Maria Barreto

; Bernardo, Larissa Cassiano

; Baptista, Simone Cristina Paixão Dias

; Fonseca, Alan Francisco

; Weber, Silke Anna Theresa

; Lima, Silvana Andrea Molina

Acta Paulista de Enfermagem

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2023, Volume 36 elocation eAPE00393

Abstract: En Es Pt | Text: En Es Pt | PDF: En | PDF: Es | PDF: Pt

Abstract Objective To evaluate the prevalence of risk for Burnout Syndrome among health professionals in areas of care for patients with COVID-19, as well as to verify possible associations of the syndrome with the perceived social support and food insecurity of these workers. Methods Analytical cross-sectional study, with workers from intensive care units (ICU) and wards caring for patients with COVID-19, in a university hospital. Data collection was carried out from September to October 2021, using the instruments: Maslach Burnout Inventory (MBI-HSS), Multidimensional Perceived Social Support Scale and Food Insecurity Experience Scale (FIES). Statistical analysis used Poisson regression models and multiple Poisson regression, considering statistically significant differences and associations if p<0.05. Results A total of 75 workers from three wards (48%) and from one ICU (52%) participated in the survey, and the professionals are mostly female (89.3%), trained as health care technicians (66.7%). Regarding the risk of Burnout Syndrome, 26.7% of the workers had scores for at least one dimension of the scale, mainly referring to high emotional exhaustion (20%). There was a positive association between the risk of developing Burnout Syndrome and food insecurity (PR = 1.11; 95%CI = (1.04; 1.18); p = 0.002). The number of children was significantly negatively associated with the incidence of Burnout Syndrome (PR = 0.90; 95%CI = (0.83; 0.97); p = 0.008). Conclusion Positive associations were observed with a higher risk of BS in professionals with food insecurity and also that the number of children acts as a protective factor against the risk of Burnout Syndrome, which may be directly related to perceived social support.

Resumen Objetivo Evaluar la prevalencia de riesgo de síndrome de burnout en profesionales de la salud de áreas de asistencia a pacientes con COVID-19, así como verificar posibles relaciones del síndrome con el apoyo social percibido y la inseguridad alimentaria de estos trabajadores. Métodos Estudio transversal analítico, con trabajadores de unidades de cuidados intensivos (UCI) y de enfermerías de asistencia a pacientes con COVID-19 en un hospital universitario. La recopilación de datos fue realizada en el período de septiembre a octubre de 2021, utilizando los instrumentos: Cuestionario Maslach de Burnout (MBI-HSS), Escala Multidimensional de Apoyo Social Percibido y Escala de Experiencias de Inseguridad Alimentaria (FIES). En el análisis estadístico se utilizaron modelos de regresión de Poisson y regresión múltiple de Poisson, donde se consideraron diferencias y asociaciones estadísticamente significativas si p<0,05. Resultados Participaron del estudio 75 trabajadores de tres enfermerías (48 %) y de una UCI (52 %), donde los profesionales, en su mayoría, eran de sexo femenino (89,3 %), graduados(as) como técnicos de enfermería (66,7 %). Con relación al riesgo de síndrome de burnout , el 26,7 % de los trabajadores presentó puntuación en por lo menos una dimensión de la escala, principalmente en la referente al alto agotamiento emocional (20 %). Se verificó una asociación positiva entre el riesgo de padecer síndrome de burnout y la inseguridad alimentaria (RP = 1,11; IC95 % = (1,04; 1,18); p = 0,002). El número de hijos se asoció significativamente de forma negativa a la incidencia de síndrome de burnout (RP = 0,90; IC95 % = (0,83; 0,97); p = 0,008). Conclusión Se observaron asociaciones positivas de mayor riesgo de síndrome de burnout en profesionales con inseguridad alimentaria, además de que el número de hijos actúa como factor protector del riesgo de síndrome de burnout , lo que puede estar directamente relacionado con el apoyo social percibido.

Resumo Objetivo Avaliar a prevalência de risco para a Síndrome de Burnout entre profissionais da saúde de áreas de atendimento a pacientes com COVID-19, bem como verificar possíveis associações da síndrome com o apoio social percebido e com a insegurança alimentar desses trabalhadores. Métodos Estudo transversal analítico, com trabalhadores de unidades de terapia intensiva (UTI) e de enfermarias de atendimento a pacientes com COVID-19, em um hospital universitário. A coleta de dados foi realizada no período de setembro a outubro de 2021, utilizando os instrumentos: Inventário de Burnout de Maslach (MBI-HSS), Escala Multidimensional de Suporte Social Percebido e Escala de Vivência da Insegurança Alimentar (FIES). A análise estatística utilizou modelos de regressão de Poisson e regressão múltipla de Poisson, sendo consideradas diferenças e associações estatisticamente significativas se p<0,05. Resultados 75 trabalhadores de três enfermarias (48%) e de uma UTI (52%) participaram da pesquisa, sendo que os profissionais são, em sua maioria, do sexo feminino (89,3%), formados(as) como técnicos de enfermagem (66,7%). Em relação ao risco de Síndrome de Burnout , 26,7% dos trabalhadores apresentaram escores para pelo menos uma dimensão da escala, principalmente à referente a alta exaustão emocional (20%); verificou-se a associação positiva entre o risco de desenvolver Síndrome de Burnout e a insegurança alimentar (RP = 1,11; IC95% = (1,04; 1,18); p = 0,002). O número de filhos associou-se significativamente de forma negativa à incidência de Síndrome de Burnout (RP = 0,90; IC95% = (0,83; 0,97); p = 0,008). Conclusão Foram observadas associações positivas de maior risco de SB em profissionais com insegurança alimentar e, também, que o número de filhos atua como fator protetivo ao risco de Síndrome de Burnout , o que pode estar relacionado diretamente ao apoio social percebido.

https://doi.org/10.37689/acta-ape/2023ao003933

Factors associated with the evolution of COVID-19 in pregnant women: a Brazilian population-based study
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Andrade, Luis Henrique de

; Santos, Gustavo Gonçalves dos

; Sordi, Mônica Aparecida de Paula de

; Nunes, Hélio Rubens de Carvalho

; Parada, Cristina Maria Garcia de Lima

Revista da Escola de Enfermagem da USP

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2023, Volume 57 elocation e202320042

Abstract: En Es Pt | Text: En Es Pt | PDF: En | PDF: Es | PDF: Pt

ABSTRACT Objective: To assess the evolution of COVID-19 among Brazilian pregnant women, identifying sociodemographic and clinical predictors related to admission to ICU - Intensive Care Unit and death. Method: Cross-sectional, population-based study, carried out with a secondary database, based on data from the Influenza Epidemiological Surveillance Information System. Descriptive analysis was performed, followed by multiple linear regression with Poisson response, adopting critical p < 0.05. Results: Intensive care admission rates of 28.2% and death rates of 9.5% were identified. Region of residence, gestational trimester, number of comorbidities and respiratory signs and symptoms were associated with the risk of admission to intensive care. Age over 34 years, comorbidities, oxygen saturation equal to or less than 95%, admission to intensive care and ventilatory support, invasive or not, increased the risk of death. Conclusion: Sociodemographic and clinical predictors showed an association with hospitalization in intensive care and death of pregnant women with COVID-19.

RESUMEN Objetivo: Evaluar la evolución de la COVID-19 entre gestantes brasileñas, identificando predictores sociodemográficos y clínicos relacionados con el ingreso en unidad de cuidados intensivos y la muerte. Método: Estudio transversal, de base poblacional, realizado con una base de datos secundaria, a partir de datos del Sistema de Información de Vigilancia Epidemiológica de Influenza. Se realizó un análisis descriptivo, seguido de regresión lineal múltiple con respuesta de Poisson, adoptando una p crítica <0,05. Resultados: Se identificaron tasas de ingreso a cuidados intensivos del 28,2% y tasas de mortalidad del 9,5%. La región de residencia, el trimestre gestacional, el número de comorbilidades y los signos y síntomas respiratorios se asociaron con el riesgo de ingreso a cuidados intensivos. La edad mayor de 34 años, las comorbilidades, la saturación de oxígeno igual o inferior al 95%, el ingreso a cuidados intensivos y el soporte ventilatorio, sea invasivo o no, aumentaron el riesgo de muerte. Conclusión: Los predictores sociodemográficos y clínicos mostraron asociación con la hospitalización en cuidados intensivos y la muerte en gestantes con COVID-19.

RESUMO Objetivo: Avaliar a evolução da COVID-19 entre gestantes brasileiras, identificando-se os preditores sociodemográficos e clínicos relacionados à internação em unidade de terapia intensiva e ao óbito. Método: Estudo transversal e de base populacional, realizado com banco de dados secundários, a partir de dados do Sistema de Informação da Vigilância Epidemiológica da Gripe. Realizou-se análise descritiva, seguida de regressão linear múltipla com resposta Poisson, adotando-se p crítico <0,05. Resultados: Identificaram-se taxas de internação em terapia intensiva de 28,2% e de óbito de 9,5%. Região de residência, trimestre gestacional, número de comorbidades e sinais e sintomas respiratórios associaram-se ao risco de internação em terapia intensiva. Idade superior a 34 anos, comorbidades, saturação de oxigênio igual ou inferior a 95%, internação em terapia intensiva e suporte ventilatório, invasivo ou não, aumentaram o risco de óbito. Conclusão: Preditores sociodemográficos e clínicos mostraram associação com a hospitalização em terapia intensiva e com o óbito de gestantes com COVID-19.

https://doi.org/10.1590/1980-220x-reeusp-2023-0042en

Relationship between primary monosymptomatic enuresis and process toilet training: a case-control
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Carvalho, Tânia Antunes

; Vasconcelos, Mônica Maria de Almeida

; Bessa Junior, José de

; Bastos Netto, José Murillo

; Dutra, Melissa Faria

; Guimarães, Isabela Cristina de Oliveira

; Lima, Eleonora Moreira

; Silva, Ana Cristina Simões e

; Mrad, Flávia Cristina de Carvalho

International braz j urol

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dec 2022, Volume 48 N. 6 Pages 944 - 951

Abstract: En | Text: En | PDF: En

ABSTRACT Objective: Primary monosymptomatic nocturnal enuresis (PMNE) is a prevalent condition in childhood, and the pathophysiology is multifactorial. This study investigated the relationship between the toilet training process (TT) and PMNE in children and adolescents. Patients and Methods: A case-control study was carried out from 2015 to 2020. The presence of PMNE was identified according to International Children's Continence Society criteria. A semi-structured questionnaire was applied to assess TT. Results: The study included 103 children and adolescents with PMNE and 269 participants with normal psychomotor development without PMNE (control group [CG]). Readiness signals were more remembered and less frequent in participants with PMNE (p=0.001) when compared to control group. No differences were found between the groups regarding the onset age of the daytime TT (p= 0.10), the nocturnal TT (p=0.08), the acquisition of daytime continence (p=0.06), and the type of equipment used for the TT (p=0.99). The use of Child-Oriented approach in group of children with enuresis was lower than in controls [87.4% (90/103) versus 94% (250/266)], respectively (OR= 0.44, 95% CI 0.21-0.94, p = 0.039). Conclusions: The age of onset of TT, acquisition of daytime continence, and the type of equipment were not associated with higher occurrence of PMNE. On the other hand, the Child-Oriented approach was a protective factor for the occurrence of PMNE.

https://doi.org/10.1590/s1677-5538.ibju.2022.0381

High prevalence of functional dyspepsia in nonalcoholic fatty liver disease: a cross-sectional study
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Lima, Érika Cristina

; Passos, Maria do Carmo Friche

; Ferolla, Silvia Marinho

; Costa, Raissa Soares Neves da

; Lisboa, Quelson Coelho

; Pereira, Lucas Ismael Dias

; Nardelli, Mateus Jorge

; Arantes, Vitor Nunes

; Ferrari, Teresa Cristina de Abreu

; Couto, Claudia Alves

Sao Paulo Medical Journal

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feb 2022, Volume 140 N. 2 Pages 199 - 206

Abstract: En | Text: En | PDF: En

Abstract BACKGROUND: Gastrointestinal (GI) symptoms are frequent complaints from individuals with nonalcoholic fatty liver disease (NAFLD). Dyspepsia is a universal clinical symptom and is among the most common GI complaints observed in the general population, but its prevalence in the population with NAFLD has not been previously investigated. OBJECTIVE: To compare the prevalence of functional dyspepsia (FD) between patients with NAFLD and controls without liver disease. DESIGN AND SETTING: Cross-sectional study at the Outpatient Liver Clinic, University Hospital, Belo Horizonte, Brazil. METHODS: We included 96 NAFLD patients and 105 controls without liver disease. All participants were assessed for GI symptoms in accordance with the Rome III criteria. Evaluation methods included a questionnaire for FD (validated in Brazil), laboratory tests and upper GI endoscopy. RESULTS: Mean age and sex were similar between the groups. The NAFLD group presented higher frequency of proton-pump inhibitor usage (31.3% vs 4.8%; P < 0.001) and prevalence of FD (25.0% versus 12.4%; P = 0.021). The symptom frequencies were as follows: postprandial distress, 22.9% versus 11.4% (P = 0.030); postprandial fullness, 18.8% versus 10.5% (P = 0.095); early satiation, 8.3% versus 5.7% (P = 0.466); and epigastric pain or burning, 18.8% versus 5.7% (P = 0.004), in NAFLD patients and controls, respectively. Multivariate analysis demonstrated that female sex (odds ratio, OR 6.97; 95% confidence interval, CI: 1.51-32.12; P = 0.013) and NAFLD diagnosis (OR 2.45; 95% CI: 1.14-5.27; P = 0.021) were independently associated with FD occurrence. CONCLUSION: FD occurs more frequently in individuals with NAFLD than in controls without hepatic disease.

https://doi.org/10.1590/1516-3180.2021.0015.r1.14062021

Neuropsychomotor development in children born preterm at 6 and 12 months of corrected gestational age
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Freitas, Nathália Faria de

; Nunes, Cynthia Ribeiro do Nascimento

; Rodrigues, Thalyta Magalhães

; Valadares, Gislene Cristina

; Alves, Fernanda Lima

; Leal, Caio Ribeiro Vieira

; Luz, Natália Maria Câmara da

; Rabello, Marina de Oliveira

; Machado, Marcia Gomes Penido

; Bouzada, Maria Candida Ferrarez

Revista Paulista de Pediatria

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2022, Volume 40 elocation e2020199

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Objetivo: Conhecer a incidência de atraso de desenvolvimento neuropsicomotor de crianças nascidas com idade gestacional menor ou igual a 32 semanas aos 6 e 12 meses de idade gestacional corrigida. Métodos: Estudo descritivo e prospectivo realizado em duas maternidades públicas. Foram incluídas 133 crianças no período de abril de 2017 a janeiro de 2019 sem fatores conhecidos para atraso no desenvolvimento neuropsicomotor. Para avaliação do desenvolvimento cognitivo e motor, utilizou-se a escala Bayley III. Para calcular o valor p das variáveis numéricas, foi usado o teste de Mann-Whitney, e para as categóricas, o teste Z de comparação de proporções. Resultados: A média da idade materna foi de 26±6,9 anos, a classificação econômica prevalente foi classe média e baixa, com percentual de 78,8%, e os recém-nascidos do sexo feminino representaram 57,1% das crianças. As crianças apresentaram maior incidência de atraso aos 12 meses, sendo 10,3% aos 12 meses e 2,3% aos 6 meses para o escore cognitivo, 22,7 e 12% aos 12 e 6 meses, respectivamente, no escore motor composto e 24,7% aos 12 meses e 8,4% aos 6 meses no escore motor fino. Conclusões: Atraso nos desenvolvimentos cognitivo e motor foi significativo, com maior incidência aos 12 meses. O escore motor composto apresentou a maior incidência de atraso de desenvolvimento. Os resultados do estudo são instigantes, uma vez que os critérios de exclusão foram abrangentes, e os atrasos no desenvolvimento neuropsicomotor, significativos.

ABSTRACT Objective: To assess the incidence of neuropsychomotor developmental delay at 6 and 12 months of corrected gestational age in children born at 32 gestational weeks or less. Methods: A descriptive and prospective study was carried out at two public maternity hospitals. Between April 2017 and January 2019, we assessed 133 children without any known risk factors for neuropsychomotor developmental delay. The Bayley III scale was used to evaluate cognitive and motor development. The p value of the numerical variables was calculated using the Mann-Whitney test, whereas proportions of categorical variables were compared using the Z-test. Results: The mean maternal age was 26±6.9 years,78.8% were from middle and lower economic classes, and 57.1% of the analyzed children were female. Children presented with a higher incidence of delay at 12 months than at 6 months (10.3 and 2.3% at 12 and 6 months, respectively, for the cognitive score; 22.7 and 12% at 12 and 6 months, respectively, for the composite motor score; and 24.7 and 8.4% at 12 and 6 months, respectively, for the fine motor score). Conclusions: Cognitive and motor developmental delays were significant, with the highest incidence at 12 months. The results of this study encourage further research on this topic, since the exclusion criteria were comprehensive and the delays in neuropsychomotor development were significant.

https://doi.org/10.1590/1984-0462/2022/40/2020199 255 downloads

10.

Biomass production and nutrient accumulation in physalis in two edaphoclimatic conditions
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Lima, Ramony Cristina

; Silva, Enilson de Barros

; Cruz, Maria do Céu Monteiro

; Ferreira, Evander Alves

; Braga Neto, Ari Medeiros

; Santos, Viktor Kayro Souza

; Bie, Dalila Costa Aparecida

Acta Scientiarum. Agronomy

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2022, Volume 44 elocation e53724

Abstract: En | Text: En | PDF: En

ABSTRACT. In Brazil, although there is a growing demand for physalis in the food industries, information on the nutritional management of the crop is still incipient. This study aimed to evaluate the biomass production and accumulation of nutrients in the shoots and fruit of physalis in two cultivation sites. Two field experiments were conducted, one where the soil was Typic Quartzipsamment in the municipality of Diamantina and the other where the soil was Rhodic Hapludox in the municipality of São João Evangelista, Minas Gerais State, Brazil. The experiments were conducted in a randomized complete block design with four replicates. The treatments were the evaluation period. Samples were collected every 15 days the day of planting of the seedlings in the field for a period of 240 days. Dry matter and nutrient accumulation in shoot and fruit were evaluated. The biomass production and nutrient accumulation were higher in the edaphoclimatic conditions at São João Evangelista compared to the conditions at Diamantina. Macronutrient accumulation was in the following order: N > K > Ca > S > Mg > P in shoot and N > K > P > S > Ca > Mg in fruit. Micronutrient accumulation in shoot and fruit was in the following order: Fe > Mn > Zn > B > Cu.

https://doi.org/10.4025/actasciagron.v44i1.53724

11.

Factors associated with hospitalizations for Covid-19 in patients with rheumatoid arthritis: data from the Reumacov Brazil registry
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Gomides, Ana Paula Monteiro

; Albuquerque, Cleandro Pires de

; Mota, Licia Maria Henrique da

; Devidé, Guilherme

; Dias, Laiza Hombre

; Duarte, Angela Luzia Branco Pinto

; Giovelli, Raquel Altoé

; Karnopp, Thais Evelyn

; Lima, Hugo Deleon de

; Marinho, Adriana

; Oliveira, Marianne Schrader de

; Omura, Felipe

; Ranzolin, Aline

; Resende, Gustavo

; Ribeiro, Francinne Machado

; Ribeiro, Sandra Lúcia Euzébio

; Sacilotto, Nathália de Carvalho

; Santos, Wander Gonzaga dos

; Shinjo, Samuel Katsuyuki

; Studart, Samia Araujo de Sousa

; Teixeira, Flávia Patricia Sena

; Yazbek, Michel Alexandre

; Ferreira, Gilda Aparecida

; Monticielo, Odirlei A.

; Paiva, Eduardo

; Pileggi, Gecilmara Cristina Salviato

; Reis Neto, Edgard Torres dos

; Pinheiro, Marcelo de Medeiros

; Marques, Claudia D. L.

Advances in Rheumatology

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2022, Volume 62 elocation 13

Abstract: En | Text: En | PDF: En

Abstract Background: Patients using immunosuppressive drugs may have unfavorable results after infections. However, there is a lack of information regarding COVID 19 in these patients, especially in patients with rheumatoid arthritis (RA). Therefore, the aim of this study was to evaluate the risk factors associated with COVID 19 hospitalizations in patients with RA. Methods: This multicenter, prospective cohort study is within the ReumaCoV Brazil registry and included 489 patients with RA. In this context, 269 patients who tested positive for COVID 19 were compared to 220 patients who tested negative for COVID 19 (control group). All patient data were collected from the Research Electronic Data Capture database. Results: The participants were predominantly female (90.6%) with a mean age of 53 ±12 years. Of the patients with COVID 19, 54 (20.1%) required hospitalization. After multiple adjustments, the final regression model showed that heart disease (OR =4.61, 95% CI 1.06–20.02. P < 0.001) and current use of glucocorticoids (OR =20.66, 95% CI 3.09–138. P < 0.002) were the risk factors associated with hospitalization. In addition, anosmia was associated with a lower chance of hospitalization (OR =0.26; 95% CI 0.10–0.67, P < 0.005). Conclusion: Our results demonstrated that heart disease and the use of glucocorticoids were associated with a higher number of hospital admissions for COVID 19 in patients with RA. Trial registration: Brazilian Registry of Clinical Trials RBR 33YTQC.

https://doi.org/10.1186/s42358-022-00244-5

12.

Evaluation of miR-15a, miR-16-1, ZAP-70, Ang-2, and Bcl-2 as potential prognostic biomarkers in chronic lymphocytic leukemia
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Braga, Tatiane Vieira

; Evangelista, Fernanda Cristina Gontijo

; Santiago, Marie Gabriele

; Ferrão, Aline Lúcia Menezes

; Almeida, Tamara Dauare de

; Barbosa, Bárbara Lima da Fonseca

; Araujo, Sergio Schusterschitz da Silva

; Ribeiro, Glaciano Nogueira

; Carvalho, Maria das Graças

; Sabino, Adriano de Paula

Brazilian Journal of Pharmaceutical Sciences

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2022, Volume 58 elocation e19332

Abstract: En | Text: En | PDF: En

Abstract Chronic lymphocytic leukemia (CLL) is a blood cancer characterized by the accumulation of clonal B-lymphocytes. This study evaluated the mRNA gene expression of miR-15a, miR-16- 1, ZAP-70, and Ang-2 by qPCR, as well as the plasma levels of Bcl-2 by Elisa immunoassay, in CLL patients and healthy controls. Significant differences were observed when comparing patients and controls regarding miR-15a (p < 0.001), miR-16-1 (p < 0.001) mRNA, Ang-2 gene expression, and Bcl-2 plasma levels (p < 0.001). When stratified by risk, differences were maintained with a significantly reduced expression in high-risk patients. A positive correlation was observed between miR-15a and platelets (R2 = 0.340; p = 0.009) as well as between Bcl-2 and leukocytes (R2 = 0.310; p = 0.019). Conversely, negative correlations were observed between ZAP-70 and platelets (R2 = - 0.334; p = 0.011), between miR-15a and lymphocytes (R2 = - 0.376; p = 0.004), as well as between miR-16-and lymphocytes (R2 = - 0.515; p = 0.00004). The data suggest that a reduction in miR-15a and miR-16-1 expressions, in addition to an overexpression of Bcl-2, are associated with the reduction in apoptosis and, consequently, to a longer survival of lymphocytes, thus contributing to lymphocyte accumulation and aggravation of the disease. By contrast, Ang-2 expression was significantly higher in A than in B + C Binet groups. This context leads to the speculation that this biomarker should be investigated in more robust studies within populations with a still relevantly indolent form of the disease in an attempt to identify those patients with a greater potential for an aggravation of the disease.

https://doi.org/10.1590/s2175-97902022e19332

13.

Fatores associados à gravidade da COVID-19 em gestantes adolescentes brasileiras: estudo de base populacional
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Duarte, Brenda Katheryne

; Parenti, Ana Beatriz Henrique

; Jamas, Milena Temer

; Nunes, Hélio Rubens De Carvalho

; Parada, Cristina Maria Garcia De Lima

Revista Latino-Americana de Enfermagem

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2022, Volume 30 N. spe elocation e3655

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

Resumo Objetivo: identificar os fatores associados à necessidade de internação em unidade de terapia intensiva em gestantes adolescentes brasileiras com COVID-19. Método: estudo de coorte não concorrente de base populacional, utilizando banco de dados secundários. Foram incluídas no estudo as gestantes adolescentes brasileiras que possuíam confirmação laboratorial de SARS-CoV-2 por Real Time, entre 14 de março de 2020 e 11 abril de 2021. Análise estatística realizada pelo modelo de regressão múltipla de Poisson, estimando-se o risco relativo e respectivos intervalos de confiança de 95%, sendo significativos valores de p <0,05. Resultados: foram incluídas na análise 282 gestantes, com mediana de idade de 17 anos, a maioria com cor da pele parda, no terceiro trimestre de gestação e residentes em zona urbana ou periurbana. A taxa de internação em unidade de terapia intensiva foi de 14,5%, associando-se a viver na região Sudeste (RR=5,03, IC95%=1,78-14,24, p=0,002), ter saturação de oxigênio inferior a 95% (RR=2,62, IC95%=1,17-5,87, p=0,019) e possuir alguma comorbidade (RR=2,05, IC95%=1,01-4,16, p=0,047). Conclusão: a taxa de internação em terapia intensiva foi elevada entre gestantes adolescentes brasileiras e associou-se a viver na região Sudeste, possuir alguma comorbidade e/ou apresentar baixa saturação de oxigênio.

Abstract Objective: to identify the factors associated with need for intensive care unit admission of Brazilian pregnant adolescents with COVID-19. Method: population-based non-concurrent cohort study using secondary databases. Brazilian pregnant adolescents who had laboratory confirmation of SARS-CoV-2 by RT-PCR, between March 14, 2020 and April 11, 2021 were included in the study. Statistical analysis using the Poisson multiple regression model, estimating the relative risk and respective 95% confidence intervals, with values of p <0.05 considered significant. Results: in total, 282 pregnant women were included in the study, with median age of 17 years, most with brown skin, in the third trimester of pregnancy, and living in urban or peri-urban areas. The intensive care unit admission rate was 14.5%, associated with living in the Southeast region of Brazil (RR=5.03, 95%CI=1.78-14.24, p=0.002), oxygen saturation below 95% (RR=2.62, 95%CI=1.17-5.87, p=0.019), and having some comorbidity (RR=2.05, 95%CI=1.01-4.16, p=0.047). Conclusion: the intensive care unit admission rate was high among Brazilian pregnant adolescents and was associated with living in the Southeast region of Brazil, having some comorbidity and/or presenting low oxygen saturation.

Resumen Objetivo: identificar los factores asociados a la necesidad de hospitalización en unidad de cuidados intensivos en adolescentes brasileñas embarazadas con COVID-19. Método: estudio de cohorte no concurrente de base poblacional, utilizando bases de datos secundarias. El estudio incluyó adolescentes brasileñas embarazadas que tuvieron confirmación de laboratorio de SARS-CoV-2 por Real Time, entre el 14 de marzo de 2020 y el 11 de abril de 2021. Análisis estadístico realizado por el modelo de regresión múltiple de Poisson, estimándose el riesgo relativo y respectivos intervalos de confianza del 95%, siendo significativos valores de p <0,05. Resultados: se incluyeron en el análisis 282 gestantes, con mediana de edad de 17 años, la mayoría de color de piel parda, en el tercer trimestre del embarazo y residentes en zona urbana o periurbana. La tasa de hospitalización en la unidad de cuidados intensivos fue del 14,5%, asociada a vivir en la región Sudeste (RR=5,03, IC95%=1,78-14,24, p=0,002), tener saturación sanguínea de oxígeno inferior al 95% (RR=2,62, IC95%=1,17-5,87, p=0,019) y tener alguna comorbilidad (RR=2,05, IC95%=1,01-4,16, p=0,047). Conclusión: la tasa de hospitalización en cuidados intensivos fue alta entre las adolescentes brasileñas embarazadas y se asoció con vivir en la región Sudeste, tener alguna comorbilidad y/o tener baja saturación de oxígeno.

https://doi.org/10.1590/1518-8345.6162.3655

14.

Aspects related to health literacy, self-care and compliance with treatment of people living with HIV
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Silva, Mônica Alice Santos da

; Lima, Morgana Cristina Leôncio de

; Dourado, Cynthia Angélica Ramos Oliveira

; Andrade, Maria Sandra

Revista da Escola de Enfermagem da USP

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2022, Volume 56 elocation e20220120

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

RESUMO Objetivo: verificar a relação entre letramento em saúde, adesão à terapia antirretroviral e autocuidado de pessoas vivendo com HIV. Método: trata-se de estudo transversal, desenvolvido entre janeiro e julho de 2019, por meio de escalas validadas sobre letramento em saúde (SAHLPA), adesão (CEAT-HIV) e autocuidado (EACAC). Resultados: participaram do estudo 303 pessoas cadastradas em três serviços de atendimento ambulatorial-HIV, apresentando grau satisfatório de letramento (52,5%), ótimo nível de autocuidado (62,9%) e adesão estrita à terapia antirretroviral (57,1%). Os não letrados apresentaram adesão medicamentosa insuficiente, quando comparados com os letrados (RP = 1,17). A adesão estrita foi significativa para o autocuidado (p-valor < 0,001). Uma maior relação de risco para o não letramento esteve associada ao sexo feminino, pessoas com ensino fundamental, que recebem benefícios, com renda de até um salário mínimo, não ter hábito de buscar informações em saúde e maior tempo de uso da TARV. Conclusão identificou-se relação entre o letramento e a adesão insuficiente. O risco para adesão medicamentosa insuficiente aumenta à medida que o autocuidado diminui. Medidas sociais redutoras de iniquidades podem contribuir para melhoria da assistência a pessoas que vivem com HIV.

ABSTRACT Objective: to verify the relationship between health literacy, compliance with antiretroviral therapy and self-care of people living with HIV. Method: this is a cross-sectional study, developed between January and July 2019, using validated scales on health literacy (SAHLPA), compliance (CEAT-HIV) and self-care (EACAC). Results: a total of 303 people enrolled in three HIV outpatient care services participated in the study, with a satisfactory level of literacy (52.5%), excellent level of self-care (62.9%) and strict compliance with antiretroviral therapy (57.1%). The illiterate had insufficient medication compliance, when compared with the literate (PR = 1.17). Strict compliance was significant for self-care (p-value < 0.001). A higher risk ratio for illiteracy was associated with females, people with elementary education, who receive benefits, with an income of up to one minimum wage, not having the habit of seeking health information and longer use of ART. Conclusion: a relationship was identified between literacy and insufficient compliance. The risk for insufficient medication compliance increases as self-care declines. Social measures that reduce inequities can contribute to improving care for people living with HIV.

RESUMEN Objetivo: verificar la relación entre la alfabetización en salud, la adherencia a la terapia antirretroviral y el autocuidado de personas que viven con VIH. Método: se trata de un estudio transversal, realizado entre enero y julio de 2019, utilizando escalas validadas de alfabetización en salud (SAHLPA), adherencia (CEAT-HIV) y autocuidado (EACAC). Resultados: Participaron del estudio 303 personas inscritas en tres servicios de atención ambulatoria de VIH, con nivel de alfabetización satisfactorio (52,5%), nivel de autocuidado excelente (62,9%) y adherencia estricta a la terapia antirretroviral (57,1%). Los analfabetos tenían adherencia insuficiente a la medicación, en comparación con los alfabetizados (RP = 1,17). La adherencia estricta fue significativa para el autocuidado (valor p < 0,001). Una mayor razón de riesgo para el analfabetismo se asoció con el sexo femenino, personas con educación básica, que perciben beneficios, con ingresos de hasta un salario mínimo, que no tienen el hábito de buscar información de salud y mayor uso de la TARV. Conclusión: se identificó una relación entre la alfabetización y la adherencia insuficiente. El riesgo de mala adherencia a la medicación aumenta a medida que disminuye el autocuidado. Las medidas sociales que reducen las desigualdades pueden contribuir a mejorar la atención de las personas que viven con el VIH.

https://doi.org/10.1590/1980-220x-reeusp-2022-0120en

15.

Blood pressure control of hypertensive patients followed in a high complexity clinic and associated variables
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Coelho, Juliana Chaves

; Guimarães, Mayra Cristina da Luz Pádua

; Campos, Cassia Lima de

; Florido, Carime Farah

; Silva, Giovanio Vieira da

; Pierin, Angela Maria Geraldo

Brazilian Journal of Nephrology

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jun 2021, Volume 43 N. 2 Pages 207 - 216

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Introdução: A hipertensão arterial é uma doença com alto impacto na mortalidade e morbidade cardiovascular, contudo ainda demonstra insuficientes taxas de controle. Objetivos: Avaliar o controle da hipertensão em pacientes atendidos em um ambulatório especializado e identificar variáveis associadas. Método: Estudo transversal com análise do prontuário de 782 pacientes atendidos em um ambulatório de alta complexidade. Critérios de inclusão: idade ≥ 18 anos e diagnóstico de hipertensão em tratamento ≥ 6 meses. Foram excluídos hipertensão secundária (104) e dados incompletos (64). O desfecho principal foi o controle da pressão arterial (Sistólica < 140 e diastólica < 90 mmHg). As variáveis independentes estudadas foram: características sociodemográficas e clínicas (uso de medicamentos, comorbidades e exames laboratoriais). Realizou-se testes χ2 de Pearson, teste Fisher, t de Student e Wilcoxon-Mann-Whitney na análise bivariada e Regressão Logística na análise múltipla, adotando p ≤ 0,05. Resultados: A prevalência de controle dos hipertensos foi 51,1%. Associou-se à falta de controle: índice de massa corporal (OR = 1,038; IC95% = 1,008 - 1,071), histórico de acidente vascular encefálico (OR = 0,453; IC95% = 0,245 - 0,821) e hipertrofia ventricular esquerda (OR = 1,765; IC95% = 1,052 - 3,011), e número de medicamentos (OR = 1,082; IC95% = 1,033 - 1,136). Conclusão: Cerca da metade dos hipertensos estava com pressão arterial controlada e variáveis clínicas e lesão em órgão alvo associaram-se ao controle.

Abstract Introduction: Arterial hypertension is a disease that has a high impact on cardiovascular mortality and morbidity; however, it is still insufficiently controlled. Objectives: To assess hypertension control in patients seen at a specialized clinic and to identify associated variables. Method: Cross-sectional study involving the analysis of medical records from 782 patients treated in a highly complex outpatient clinic. Inclusion criteria: age ≥18 years, diagnosed with hypertension, in treatment ≥6 months. Patients with secondary hypertension (104) and incomplete data (64) were excluded. The main outcome was blood pressure control (systolic <140 and diastolic <90 mmHg). The independent variables studied were: sociodemographic and clinical characteristics (use of drugs, comorbidities and laboratory tests). Pearson's χ2 tests, Fisher's test, Student's t and Wilcoxon-Mann-Whitney tests were performed in the bivariate analysis and logistic regression in the multiple analyses, adopting p≤0.05. Results: The prevalence of hypertensive control was 51.1%. It was associated with a lack of control: body mass index (OR = 1.038; 95% CI = 1.008 - 1.071), history of stroke (OR = 0.453; 95% CI = 0.245 - 0.821), left ventricular hypertrophy (OR = 1.765; 95% CI = 1.052 - 3.011), and number of medications (OR = 1.082; 95% CI = 1.033 - 1.136). Conclusion: About half of the hypertensive patients had their blood pressure controlled; clinical variables and target organ damage were associated with the control.

https://doi.org/10.1590/2175-8239-jbn-2020-0133 428 downloads

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