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au:Lima, Fabio Carlos Alves

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[SciELO Preprints] - Guidelines on the Diagnosis and Treatment of Hypertrophic Cardiomyopathy – 2024
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Fernandes, Fabio Simões, Marcus V. Correia, Edileide de Barros Marcondes-Braga, Fabiana G. Coelho-Filho, Otavio Rizzi Mesquita, Cláudio Tinoco Mathias-Junior, Wilson Rochitte, Carlos Eduardo Ramires, Felix José Alvarez Alves, Silvia Marinho Martins Montera, Marcelo Westerlund Lopes, Renato Delascio Oliveira-Junior, Mucio Tavares Scolari, Fernando L. Avila, Walkiria Samuel Canesin, Manoel Fernandes Bacal, Fernando Bocchi, Edimar Alcides Moura, Lídia Ana Zytynski Saad, Eduardo Benchimol Scanavacca, Mauricio I. Valdigem, Bruno Pereira Cano , Manuel Nicolas Abizaid , Alexandre Ribeiro, Henrique Barbosa Lemos-Neto, Pedro Alves Ribeiro, Gustavo Calado de Aguiar Jatene, Fabio Biscegli Dias, Ricardo Ribeiro Beck-da-Silva, Luis Rohde, Luis Eduardo P. Bittencourt, Marcelo Imbroinise Pereira, Alexandre Krieger, José Eduardo Villacorta, Humberto Martins, Wolney de Andrade Figueiredo-Neto, José Albuquerque de Cardoso , Juliano Novaes Pastore, Carlos Alberto Jatene, Ieda Biscegli Tanaka, Ana Cristina Sayuri Hotta, Viviane Tiemi Romano, Minna Moreira Dias Albuquerque, Denilson Campos de Mourilhe-Rocha, Ricardo Hajjar, Ludhmila Abrahão Brito, Fabio Sandoli de Caramelli , Bruno Calderaro, Daniela Farsky, Pedro Silvio Colafranceschi , Alexandre Siciliano Pinto, Ibraim Masciarelli Vieira , Marcelo Luiz Campos Danzmann, Luiz Claudio Barberato , Silvio Henrique Mady, Charles Martinelli-Filho, Martino Torbey , Ana Flavia Malheiros Schwartzmann, Pedro Vellosa Macedo, Ariane Vieira Scarlatelli Ferreira , Silvia Moreira Ayub Schmidt, Andre Melo , Marcelo Dantas Tavares de Lima-Filho, Moysés Oliveira Sposito, Andrei C. Brito, Flavio de Souza Biolo, Andreia Madrini-Junior, Vagner Rizk, Stéphanie Itala Mesquita, Evandro Tinoco

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Publication date: 2024-04-08

Abstract: Pt Es En

A cardiomiopatia hipertrófica (CMH) é uma forma de doença do músculo cardíaco de causa genética, caracterizada pela hipertrofia das paredes ventriculares. O diagnóstico requer detecção por métodos de imagem (Ecocardiograma ou Ressonância Magnética Cardíaca) de qualquer segmento da parede do ventrículo esquerdo com espessura > 15 mm, sem outra causa provável. A análise genética permite identificar mutações de genes codificantes de diferentes estruturas do sarcômero responsáveis pelo desenvolvimento da CMH em cerca de 60% dos casos, permitindo o rastreio de familiares e aconselhamento genético, como parte importante do manejo dos pacientes e familiares. Vários conceitos sobre a CMH foram recentemente revistos, incluindo sua prevalência de 1 em 250 indivíduos, não sendo, portanto, uma doença rara, mas subdiagnosticada. A vasta maioria dos pacientes é assintomática. Naqueles sintomáticos, a obstrução do trato de saída do ventrículo esquerdo (OTSVE) é o principal distúrbio responsável pelos sintomas, devendo-se investigar a sua presença em todos os casos. Naqueles em que o ecocardiograma em repouso ou com Manobra de Valsalva não detecta gradiente intraventricular significativo (> 30 mmHg), devem ser submetidos à ecocardiografia com esforço físico para detecção da OTSVE.   Pacientes com sintomas limitantes e grave OTSVE, refratários ao uso de betabloqueadores e verapamil, devem receber terapias de redução septal ou uso de novas drogas inibidoras da miosina cardíaca. Por fim, os pacientes adequadamente identificados com risco aumentado de morta súbita podem receber medida profilática com implante de cardiodesfibrilador implantável (CDI).

La miocardiopatía hipertrófica (MCH) es una forma de enfermedad cardíaca de origen genético, caracterizada por el engrosamiento de las paredes ventriculares. El diagnóstico requiere la detección mediante métodos de imagen (Ecocardiograma o Resonancia Magnética Cardíaca) que muestren algún segmento de la pared ventricular izquierda con un grosor > 15 mm, sin otra causa probable. El análisis genético permite identificar mutaciones en genes que codifican diferentes estructuras del sarcómero responsables del desarrollo de la MCH en aproximadamente el 60% de los casos, lo que permite el tamizaje de familiares y el asesoramiento genético, como parte importante del manejo de pacientes y familiares. Varios conceptos sobre la MCH han sido revisados recientemente, incluida su prevalencia de 1 entre 250 individuos, por lo tanto, no es una enfermedad rara, sino subdiagnosticada. La gran mayoría de los pacientes son asintomáticos. En los casos sintomáticos, la obstrucción del tracto de salida ventricular izquierdo (TSVI) es el trastorno principal responsable de los síntomas, y su presencia debe investigarse en todos los casos. En aquellos en los que el ecocardiograma en reposo o la maniobra de Valsalva no detecta un gradiente intraventricular significativo (> 30 mmHg), deben someterse a ecocardiografía de esfuerzo para detectar la obstrucción del TSVI. Los pacientes con síntomas limitantes y obstrucción grave del TSVI, refractarios al uso de betabloqueantes y verapamilo, deben recibir terapias de reducción septal o usar nuevos medicamentos inhibidores de la miosina cardíaca. Finalmente, los pacientes adecuadamente identificados con un riesgo aumentado de muerte súbita pueden recibir medidas profilácticas con el implante de un cardioversor-desfibrilador implantable (CDI).

Hypertrophic cardiomyopathy (HCM) is a form of genetically caused heart muscle disease, characterized by the thickening of the ventricular walls. Diagnosis requires detection through imaging methods (Echocardiogram or Cardiac Magnetic Resonance) showing any segment of the left ventricular wall with a thickness > 15 mm, without any other probable cause. Genetic analysis allows the identification of mutations in genes encoding different structures of the sarcomere responsible for the development of HCM in about 60% of cases, enabling screening of family members and genetic counseling, as an important part of patient and family management. Several concepts about HCM have recently been reviewed, including its prevalence of 1 in 250 individuals, hence not a rare but rather underdiagnosed disease. The vast majority of patients are asymptomatic. In symptomatic cases, obstruction of the left ventricular outflow tract (LVOT) is the primary disorder responsible for symptoms, and its presence should be investigated in all cases. In those where resting echocardiogram or Valsalva maneuver does not detect significant intraventricular gradient (> 30 mmHg), they should undergo stress echocardiography to detect LVOT obstruction. Patients with limiting symptoms and severe LVOT obstruction, refractory to beta-blockers and verapamil, should receive septal reduction therapies or use new drugs inhibiting cardiac myosin. Finally, appropriately identified patients at increased risk of sudden death may receive prophylactic measure with implantable cardioverter-defibrillator (ICD) implantation.

https://doi.org/10.1590/SciELOPreprints.8394

Growth phenotypes of very low birth weight infants for prediction of neonatal outcomes from a Brazilian cohort: comparison with INTERGROWTH
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Cardoso, Viviane Cunha

; Grandi, Carlos

; Silveira, Rita C.

; Duarte, José Luiz Bandeira

; Viana, Maria Cândida Ferrarez Bouzada

; Ferreira, Daniela Marques de Lima Mota

; Alves Junior, José Mariano Sales

; Embrizi, Laís Furlan

; Gimenes, Carolina Boschi

; Mello e Silva, Nathalia Moura de

; Melo, Fernanda Pegoraro de Godoi

; Venzon, Paulyne Stadler

; Gomez, Dafne Barcala

; Vale, Marynéa Silva do

; Bentlin, Maria Regina

; Barros, Marina Carvalho de Moraes

; Bigélli, Laura Emilia Monteiro

; Diniz, Edna Maria de Albuquerque

; Luz, Jorge Hecker

; Marba, Sérgio Tadeu Martins

; Almeida, João Henrique Carvalho Leme de

; Aragon, Davi Casale

; Carmona, Fabio

Jornal de Pediatria

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jan 2023, Volume 99 N. 1 Pages 86 - 93

Abstract: En | Text: En | PDF: En

Abstract Objective: To assess the predictive value of selected growth phenotypes for neonatal morbidity and mortality in preterm infants < 30 weeks and to compare them with INTERGROWTH-21st (IG21). Methods: Retrospective analysis of data from the Brazilian Neonatal Research Network (BNRN) database for very low birth weight (VLBW) at 20 public tertiary-care university hospitals. Outcome: the composite neonatal morbidity and mortality (CNMM) consisted of in-hospital death, oxygen use at 36 weeks, intraventricular hemorrhage grade 3 or 4, and Bell stage 2 or 3 necrotizing enterocolitis. Selected growth phenotypes: small-for-gestational-age (SGA) defined as being < 3rd (SGA3) or 10th (SGA10) percentiles of BW, and large-for-gestational-age (LGA) as being > 97th percentile of BW. Stunting as being < 3rd percentile of the length and wasting as being < 3rd percentile of BMI. Single and multiple log-binomial regression models were fitted to estimate the relative risks of CNMM, comparing them to IG21. Results: 4,072 infants were included. The adjusted relative risks of CNMM associated with selected growth phenotypes were (BNRN/IG21): 1.45 (0.92–2.31)/1.60 (1.27–2.02) for SGA; 0.90 (0.55–1.47)/1.05 (0.55–1.99) for LGA; 1.65 (1.08–2.51)/1.58 (1.28–1.96) for stunting; and 1.48 (1.02–2.17) for wasting. Agreement between the two references was variable. The growth phenotypes had good specificity (>95%) and positive predictive value (70-90%), with poor sensitivity and low negative predictive value. Conclusion: The BNRN phenotypes at birth differed markedly from the IG21 standard and showed poor accuracy in predicting adverse neonatal outcomes.

https://doi.org/10.1016/j.jped.2022.07.007

The rarest of the rare: rediscovery and status of the critically endangered Belem Curassow, Crax fasciolata pinima (Pelzeln, 1870)
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Alteff, Eduardo França

; Gonsioroski, Gustavo

; Barreiros, Marcelo

; Torres, Leonardo Gabriel Campos de Oliveira

; Camilo, André Restel

; Mozerle, Hugo Borghezan

; Sousa, Antônio Emanuel Barreto Alves de

; Medolago, César Augusto Bronzatto

; Martínez, Carlos

; Lima, Diego Mendes

; Ubaid, Flávio Kulaif

; Mendonça, Eloisa Neves

; Tomotani, Barbara Mizumo

; Silveira, Luís Fábio

Papéis Avulsos de Zoologia

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2019, Volume 59 elocation e20195946

Abstract: En | Text: En | PDF: En

Abstract The Belem Curassow (Crax fasciolata pinima) is one of the most endangered birds in South America, without sightings of birds in the wild for 40 years. This subspecies is nationally and internationally classified as critically endangered and close to extinction, suffering from poaching and deforestation in its range. Here we present new records of free-living individuals made on three indigenous lands in Pará and Maranhão states: in part of Terra Indígena Mãe Maria, Bom Jesus do Tocantins, Pará; in locations within the Reserva Biológica do Gurupi/Terra Indígena Alto Turiaçu, Centro Novo do Maranhão, Maranhão; and around the Terra Indígena Rio Pindaré, Alto Alegre do Pindaré, Maranhão. We also provide recommendations to protect this bird via a dedicated conservation program which includes finding new individuals in non-sampled areas (north of BR-222), estimating population size, enhancing taxonomic and natural history knowledge, capturing wild animals in order to start urgent ex situ conservation programs, and developing environmental awareness programs with the local and indigenous populations.

https://doi.org/10.11606/1807-0205/2019.59.46 795 downloads

Anatomical terminology of the internal nose and paranasal sinuses: cross-cultural adaptation to Portuguese
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Bezerra, Thiago Freire Pinto

; Stamm, Aldo

; Anselmo-Lima, Wilma Teresinha

; Fornazieri, Marco Aurélio

; Melo, Nelson D’Ávila

; Balsalobre, Leonardo

; Jotz, Geraldo Pereira

; Leão, Henrique Zaquia

; Nunes, André Alencar Araripe

; Felippu, Alexandre

; Cedin, Antonio Carlos

; Pinheiro-Neto, Carlos D.

; Oliveira, Diego Lima

; Sakano, Eulalia

; Kosugi, Eduardo Macoto

; Araújo, Elizabeth

; Valera, Fabiana Cardoso Pereira

; Pinna, Fábio de Rezende

; Romano, Fabrizio Ricci

; Pádua, Francine Grecco de Melo

; Ramos, Henrique Faria

; Telles Jr., João

; Sá, Leonardo Conrado Barbosa de

; D'Assunção Filho, Leopoldo Marques

; Sennes, Luiz Ubirajara

; Gregório, Luis Carlos

; Sampaio, Marcelo H.

; Santos, Marco César Jorge dos

; Franca, Marco

; Mocellin, Marcos

; Lessa, Marcus Miranda

; Avelino, Melissa Ameloti G.

; Tepedino, Miguel

; Andrade, Nilvano Alves de

; Piltcher, Otavio B.

; Roithmann, Renato

; Pilan, Renata Mendonça

; Meireles, Roberto Campos

; Guimarães, Roberto Eustáquio

; Santos, Rodrigo de Paula

; Pezato, Rogério

; Pignatari, Shirley

; Abdo, Tatiana Telles

; Nakajima, Victor

; Almeida, Washington

; Nakanishi, Marcio

; Voegels, Richard L.

Brazilian Journal of Otorhinolaryngology

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dec 2018, Volume 84 N. 6 Pages 677 - 686

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo: Introdução: A cirurgia endoscópica funcional endonasal é um procedimento cirúrgico frequente entre os otorrinolaringologistas. Em 2014, a Sociedade Europeia de Rinologia publicou o "Documento Europeu para Posicionamento sobre a Terminologia Anatômica Interna do Nariz e das Cavidades Paranasais" com o objetivo de unificar os termos na língua inglesa. Ainda não dispomos de uma terminologia unificada na língua portuguesa. Objetivo: Adaptação transcultural dos termos anatômicos do nariz e das cavidades paranasais para o português da "European Anatomical Terminology of the Internal Nose and Paranasal Sinuses". Método: Um grupo de rinologistas de todo o Brasil, com experiência em cirurgia endoscópica endonasal, foi convidado a participar da elaboração desse posicionamento sobre os termos anatômicos do nariz e das cavidades paranasais para o português conforme metodologia adaptada da previamente descrita por Rudmik e Smith. Resultados: Os resultados desse documento foram gerados a partir da concordância da maioria dos participantes conforme as sugestões mais populares entre os rinologistas. Uma adaptação transcultural da terminologia anatômica nasossinusal foi consolidada. Sugerimos que se busque uniformizar termos como "concha inferior", "septo nasal", "porção (óssea/cartilaginosa) do septo nasal", "meato (médio/ inferior) nasal", "via da drenagem do seio frontal", "recesso frontal" e "processo uncinado". Conclusão: Consolidamos uma versão adaptada em português da "European Anatomical Terminology of the Internal Nose and Paranasal Sinuses" que auxiliará a publicação de comunicados técnicos, publicações científicas e o ensino dos termos anatômicos internos do nariz e das cavidades paranasais no Brasil.

Abstract Introduction: Functional endonasal endoscopic surgery is a frequent surgical procedure among otorhinolaryngologists. In 2014, the European Society of Rhinology published the "European Position Paper on the Anatomical Terminology of the Internal Nose and Paranasal Sinuses", aiming to unify the terms in the English language. We do not yet have a unified terminology in the Portuguese language. Objective: Transcultural adaptation of the anatomical terms of the nose and paranasal cavities of the "European Anatomical Terminology of the Internal Nose and Paranasal Sinuses" to Portuguese. Methods: A group of rhinologists from diverse parts of Brazil, all experienced in endoscopic endonasal surgery, was invited to participate in the creation of this position paper on the anatomical terms of the nose and paranasal sinuses in the Portuguese language according to the methodology adapted from that previously described by Rudmik and Smith. Results: The results of this document were generated based on the agreement of the majority of the participants according to the most popular suggestions among the rhinologists. A cross-cultural adaptation of the sinonasal anatomical terminology was consolidated. We suggest the terms "inferior turbinate", "nasal septum", "(bone/cartilaginous) part of the nasal septum", "(middle/inferior) nasal meatus", "frontal sinus drainage pathway", "frontal recess" and "uncinate process" be standardized. Conclusion: We have consolidated a Portuguese version of the European Anatomical Terminology of the Internal Nose and Paranasal Sinuses, which will help in the publication of technical announcements, scientific publications and the teaching of the internal anatomical terms of the nose and paranasal sinuses in Brazil.

https://doi.org/10.1016/j.bjorl.2018.08.003 1085 downloads

Evaluation of collared anteaters (Tamandua tetradactyla) presented in a wildlife health reference center of São Paulo state, Brazil
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Bernegossi, Agda Maria

; Rahal, Sheila Canevese

; Melchert, Alessandra

; Teixeira, Carlos Roberto

; Lima, Fábio Henrique

; Medeiros, Raphael Duarte

; Alves da Silva, Aline

Biota Neotropica

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2018, Volume 18 N. 1 elocation e20170440

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo O desmatamento e a construção de estradas têm promovido uma série de problemas à fauna. Visando contribuir com informações que podem ser usadas na compreensão e preservação das espécies, o trabalho teve por objetivo avaliar tamanduás-mirins atendidos em um centro de referência localizado no Estado de São Paulo, Brazil. Foram avaliados retrospectivamente dados referentes a tamanduás-mirins (Tamandua tetradactyla), que foram trazidos ao Centro de Medicina e Pesquisa em Animais Selvagens (CEMPAS), durante um período de 13 anos. De um total de 46 tamanduás-mirins atendidos, 14 foram machos e 10 foram fêmeas, e 22 não possuíam identificação quanto ao sexo. Em média, os machos adultos pesaram 4,41 kg, enquanto as fêmeas adultas pesaram 4,95 kg. Com relação à circunstância que levou ao atendimento, as mais importantes foram o atropelamento (36,96%) e a mordedura de cães (21,74%), sendo que 23,91% foram considerados clinicamente saudáveis. No tocante à evolução dos casos, 36,96% (n=17) foram reintroduzidos, 34.78% (n=16) foram a óbito, 15,22% (n=7) foram transferidos para outras instituições, 6,52% (n=3) evadiram do recinto e 6,52% (n=3) não há informação. Os animais foram provenientes principalmente dos municípios de Botucatu (21,73%), São Manuel (17,39%), Lençóis Paulista (6,52%) e Bauru (4,34%), sendo a SP-300 a principal rodovia relacionada as ocorrências. Foi possível concluir que dos tamanduás-mirins avaliados a principal causa de lesão foi o atropelamento, que teve por evolução o óbito; porém ao se incluir os tamanduás-mirins saudáveis e demais, ao menos metade evoluíram positivamente.

Abstract Deforestation and road construction have inflicted negative effects on wildlife populations. To contribute to the comprehension and preservation of wildlife species, this study aimed to evaluate collared anteater presented to a reference center located in São Paulo state, Brazil. Furthermore, the locations where the animals were most frequently found were determined. Data on collared anteaters (Tamandua tetradactyla) examined at the Center for Medicine and Research in Wild Animals (CEMPAS) were evaluated retrospectively for a period of 13 years. A total of 46 collared anteaters was examined, comprised of 14 males, 10 females, and 22 without identifying information. On average, adult males weigh 4.41 kg while adult females weigh 4.95 kg. The most common admission circumstance was vehicular strikes (36.96%), followed by dog bites (21.74%); 23.91% were considered clinically healthy. Animal outcomes were 36.96% (n=17) reintroduced, 34.78% (n=16) fatalities, 15.22% (n=7) transferred to other institutions, and 6.52% (n=3) escaped from the enclosure; and 6.52% (n=3) presented no medical record information. The collared anteaters were found mainly in the municipal areas of Botucatu (21.73%), São Manuel (17.39%), Lençóis Paulista (6.52%), and Bauru (4.34%), with SP-300 being the main highway associated with the occurrences. In conclusion, the main cause of lesion in the collared anteaters evaluated in this study was vehicular strike that that led to death. However, including all collared anteaters at least half of them had a positive outcome.

https://doi.org/10.1590/1676-0611-bn-2017-0440 1310 downloads

Synthesis and biological evaluation of novel imidazolidine derivatives as candidates to schistosomicidal agents
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Matos-Rocha, Thiago José

; Lima, Maria do Carmo Alves de

; Silva, Anekécia Lauro da

; Oliveira, Jamerson Ferreira de

; Gouveia, Allana Lemos Andrade

; Silva, Vinícius Barros Ribeiro da

; Almeida Júnior, Antônio Sérgio Alves de

; Brayner, Fábio André

; Cardoso, Pablo Ramon Gualberto

; Pitta-Galdino, Marina da Rocha

; Pitta, Ivan da Rocha

; Rêgo, Moacyr Jesus Barreto de Melo

; Alves, Luiz Carlos

; Pitta, Maira Galdino da Rocha

Revista do Instituto de Medicina Tropical de São Paulo

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2017, Volume 59 elocation e8

Abstract: En | Text: En | PDF: En

ABSTRACT Introduction: Schistosomiasis is an infectious parasitic disease caused by trematodes of the genus Schistosoma, which threatens at least 258 million people worldwide and its control is dependent on a single drug, praziquantel. The aim of this study was to evaluate the anti-Schistosoma mansoni activity in vitro of novel imidazolidine derivatives. Material and methods: We synthesized two novel imidazolidine derivatives: (LPSF/PTS10) (Z)-1-(2-chloro-6-fluorobenzyl)-4-(4-dimethylaminobenzylidene)-5-thioxoimidazolidin-2-one and (LPSF/PTS23) (Z)-1-(2-chloro-6-fluoro-benzyl)-5-thioxo-4-(2,4,6-trimethoxy-benzylidene)-imidazolidin-2-one. The structures of two compounds were determined by spectroscopic methods. During the biological assays, parameters such as motility, oviposition, mortality and analysis by Scanning Electron Microscopy were performed. Results: LPSF/PTS10 and LPSF/PTS23 were considered to be active in the separation of coupled pairs, mortality and to decrease the motor activity. In addition, LPSF/PTS23 induced ultrastructural alterations in worms, after 24 h of contact, causing extensive erosion over the entire body of the worms. Conclusion: The imidazolidine derivatives containing the trimetoxy and benzylidene halogens showed promising in vitro schistosomicidal activity.

https://doi.org/10.1590/s1678-9946201759008 2241 downloads

Respostas de lactato, esforço percebido, frequência cardíaca, triptofano, prolactina e ácidos graxos à série de natação na velocidade crítica
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Franken, Marcos

; Lima, Fabio Carlos Alves

; Mazzola, Priscila Nicolao

; Martins, Jocelito Bijoldo

; Teixeira, Bruno Costa

; Dutra Filho, Carlos Severo

; Castro, Flávio Antônio de Souza

Revista Brasileira de Ciências do Esporte

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jun 2014, Volume 36 N. 2 Pages 353 - 368

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

O estudo avaliou, na intensidade de 100% da velocidade crítica (VC), o comportamento de concentração de lactato sanguíneo ([LA]), esforço percebido (EP), frequência cardíaca (FC), concentrações plasmáticas de triptofano [TRP], de prolactina ([PRL]) e de ácidos graxos livres ([AGL]). Catorze nadadores realizaram dois protocolos distintos: 1) repetições de 200 e 400 m, em máxima intensidade (V200 e V400) para a determinação da VC; 2) série VC (repetições de 400 m), com intervalos de 40 s. Os principais resultados foram: (1) [TRP] e [AGL] não apresentaram diferenças entre repouso e exaustão (p > 0,05); (2) aumento da [PRL], da [LA], da FC e do EP (p < 0,05) ao longo da série VC. Assim o aumento da [PRL] pode indicar manifestação de fadiga central na intensidade correspondente à VC.

The study assessed, at the intensity of 100% of the critical speed (CS), the behavior of blood lactate concentration ([La]), rating of perceived exertion (RPE), heart rate (HR), plasma concentrations of tryptophan [TRP] of prolactin ([PRL]) and free fatty acids ([FFA]). Fourteen swimmers performed two protocols: 1) trials of 200 and 400 m at maximum intensity (V200 and V400) for the CS, 2) CS series (trials of 400 m), and rest intervals of 40 s. The main results were: (1) [TRP] and [FFA] did not differ between rest and exhaustion (p> 0.05), (2) increased [PRL], the [La], HR and RPE (p <0.05) throughout the series CS. Thus the increase in [PRL] may indicate manifestation of central fatigue in intensity corresponding to the CS.

Este estudio evaluó, en la intensidad del 100% de la velocidad crítica (CV), el comportamiento de la concentración de lactato en la sangre ([LA]), esfuerzo percibido (PE), frecuencia cardíaca (FC), concentración plasmática de triptófano [TRP], prolactina ([PRL]) y de ácidos grasos libres ([AGL]). Catorce nadadores realizaron dos protocolos: 1) repeticiones de 200 y 400 m en máxima intensidad (V200 y V400) para la determinación de la CV, 2) serie VC (repeticiones de 400 m), con intervalos de 40 s. Los principales resultados fueron: (1) [TRP] y [FFA] no fueran diferentes entre el descanso y el agotamiento (p> 0,05), (2) mayores [PRL], [LA], FC y EP (p <0,05) a lo largo de la serie VC. Por lo tanto, el aumento de [PRL] pude indicar manifestación de fatiga central en la intensidad correspondiente a la VC.

https://doi.org/10.1590/S0101-32892014000200006 3434 downloads

Evolução clínica após intervenção coronária percutânea em indivíduos com transplante renal prévio
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Trentin, Fábio

; Melo, Eduardo França Pessoa de

; Santo, Carlos Vinicius Abreu do Espírito

; Paula, Flavio Jota de

; Nahas, William Carlos

; Spadaro, André Gasparin

; Lima, Jose Jayme de

; Gowdak, Luiz Henrique

; Campos, Carlos Augusto Homem de Magalhães

; Lemos Neto, Pedro Alves

Revista Brasileira de Cardiologia Invasiva

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jun 2013, Volume 21 N. 2 Pages 128 - 132

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

INTRODUÇÃO: A doença arterial coronária é uma das principais causas de óbito em pacientes com doença renal crônica. Além disso, em decorrência da elevada prevalência de fatores de risco para aterosclerose, muitos desses pacientes necessitam de intervenção coronária percutânea (ICP) mesmo após o transplante renal. O objetivo deste estudo é descrever a evolução tardia de pacientes transplantados renais submetidos a ICP com stent. MÉTODOS: Foram incluídos pacientes transplantados renais, com idade > 18 anos, tratados com ICP. O seguimento foi realizado por análise de prontuários e contato telefônico. O desfecho do estudo foi a incidência de eventos cardíacos adversos maiores (ECAM) durante o seguimento. RESULTADOS: Foram incluídos 29 pacientes. A média de idade foi de 54,8 ± 8 anos, sendo a maioria do sexo masculino (72,4%). A prevalência de hipertensão arterial sistêmica foi de 89,7%, de dislipidemia, de 69%, e de diabetes, de 51,7%. A maior parte apresentava doença multiarterial (biarterial: 44,8%; triarterial: 41,4%). A complexidade das lesões foi elevada, sendo 84,3% dos tipos B2 ou C e 27,5% com lesões em bifurcação. A taxa de sucesso do procedimento foi de 100%. Stents convencionais foram utilizados em 96,6% dos casos. O tempo de seguimento foi de 1.378 ± 977 dias. A mortalidade foi de 25,1%, a taxa de revascularização do vaso-alvo foi de 15,9% e nenhum paciente apresentou infarto não-fatal. A incidência de ECAM durante a evolução foi de 34,5%. CONCLUSÕES: A evolução clínica tardia após ICP em pacientes transplantados renais demonstrou elevada probabilidade de eventos clínicos. No entanto, a população estudada foi uma amostra de alta complexidade clínica e angiográfica.

BACKGROUND: Coronary artery disease is a major cause of death in patients with chronic kidney disease. Moreover, due to the high prevalence of risk factors for atherosclerosis, many of these patients require percutaneous coronary intervention (PCI) even after renal transplantation. The aim of this study is to report the late follow-up of patients with renal transplantation treated with PCI and stenting. METHODS: Patients > 18 years of age, with prior kidney transplantation, and treated with PCI were included. Clinical follow-up was evaluated by medical record analysis and telephone contact. The study endpoint was the incidence of major adverse cardiac events (MACE) during follow-up. RESULTS: Twenty-nine patients were included. Mean age was 54.8 ± 8 years and the majority male (72.4%). The prevalence of hypertension was 89.7%, dyslipidemia 69% and diabetes 51.7%. Most of them had multivessel disease (2-vessel: 44.8%; 3-vessel: 41.4%). Lesion complexity was high, being 84.3% type B2 or C lesions and 27.5% bifurcation lesions. Procedural success rate was 100%. Bare metal stents were used in 96.6% of cases. The follow-up time was 1,378 ± 977 days. The mortality rate was 25.1%, target vessel revascularization rate was 15.9% and none of the patients presented non-fatal infarction. The incidence of MACE during follow-up was 34.5%. CONCLUSIONS: Late follow-up after PCI in renal transplantation patients demonstrated a high probability of clinical events. However, the study population was a sample of high clinical and angiographic complexity.

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Diretriz de interpretação de eletrocardiograma de repouso
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Guimarães, Jorge Ilha

; Nicolau, José Carlos

; Polanczyk, Carisi A.

; Pastore, Carlos Alberto

; Pinho, José Alves

; Bacellar, Mario Sérgio de Carvalho

; Ribeiro, Demostenes G. Lima

; Darwich, Rubens Nassar

; Ribeiro, Antonio Luiz Pinho

; Dunda, Marcelo Marcos Eloy

; Germiniani, Hélio

; França, Francisco Faustino

; Saraiva, Laurindo

; Ribeiro, Clébia Maria Rios

; Ginefra, Paulo

; Gus, Iseu

; Fernandes, Eney

; Riera, Andres

; Pedrosa, Anisio

; Friedman, Antonio Américo

; Firmiani, Antonio Carlos

; Grupi, Cesar

; Pinho, Claudio

; Lima, Eduardo Vilaça

; Kaiser, Elisabeth

; Brito, Fábio Sandoli

; Vinhas, Gilberto Luiz Castro

; Schwartz, Hélio

; Grindler, José

; Aziz, José Luiz

; Figueiredo, Marcio

; Molina, Marcos S.

; Martinelli, Martino

; Tobias, Nancy

; Sanches, Paulo Cesar R.

; Moffa, Paulo Jorge

; Attanes Neto, Severino

; Nishioka, Silvana

Arquivos Brasileiros de Cardiologia

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2003, Volume 80 Suppl. 2 Pages 1 - 18

Abstract: Pt | Text: Pt | PDF: Pt

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