Results: 26
#1
au:LIMA, RENATO SOUSA
Filters
Order by
Page
of 2
Next
1.
Intersectionality and mental health in university students: a jeopardy index approach
Facebook Twitter

Facebook Twitter
- Other social networks
- Google+
- StambleUpon
- CiteULike
- Mendeley
- Other networks
- Metrics
Lima, Juliana Dias de
; Plácido, Jessica
; Andrade, Beatriz
; Abend, Letícia Dalcero
; Waclawovsky, Aline Josiane
; Pires, Daniel Alvarez
; Silva, Danilo Rodrigues Pereira da
; Jesus-Moraleida, Fabianna Resende de
; Moura, Helena Ferreira
; Coelho, Nicole Leite Galvão
; Monteiro-Junior, Renato Sobral
; Matias, Thiago Sousa
; Schuch, Felipe Barreto
; Deslandes, Andrea Camaz
.














ABSTRACT OBJECTIVE: To explore the associations between current mental health symptoms and social disparities in university students. METHODS: We recruited participants from nine public universities in Brazil, from August to November 2022, using online advertisements and in-person lectures. All participants completed an online survey containing social (sex, race/color, gender identity, sexual orientation, and income) and mental health assessments. The Jeopardy index was composed of social variables. The index considered zero points for subjects with less oppressive experienced characteristics (men, White, cisgender, heterosexual, higher income) and one point for the opposite characteristics. We defined six clusters according to Jeopardy Index results: 0, 1, 2, 3, 4, and 5 points, with the greatest number of points representing the most disadvantaged group. The mental health symptoms were assessed on two levels. First by the “DSM-5 Self-Rated Level 1 Cross-Cutting Symptom Measure – Adult,” and second by the “Patient Health Questionnaire-9,” and the “Generalized Anxiety Disorder Questionnaire-7.” Adjusted Odds Ratio (OR) analyses was performed for age and educational level. RESULTS: 748 participants were allocated into the six Jeopardy clusters: 0 (n = 46; 6.1%), 1 (n = 112; 15.0%), 2 (n = 163; 21.8%), 3 (n = 218; 29.1%), 4 (n = 171; 22.9%), and 5 (n = 38; 5.1%). It was observed a high prevalence of anxiety (42.5%) and depression (51.0%), however, the less privileged group (5) had a higher risk of having severe symptoms of anxiety (OR = 6.21; 1.51–25.58; p < 0.01) and depression (OR = 8.60; 2.15–34.43; p < 0.01), compared against the most privileged group. CONCLUSION: Although anxiety and depressive symptoms were highly prevalent for all participants, these disorders are not equally distributed in this population and the intersectionality between social factors plays an important role in contributing to these differences.
2.
Intersectionality and mental health in university students: a jeopardy index approach
Facebook Twitter

Facebook Twitter
- Other social networks
- Google+
- StambleUpon
- CiteULike
- Mendeley
- Other networks
- Metrics
Lima, Juliana Dias de
; Plácido, Jessica
; Andrade, Beatriz
; Abend, Letícia Dalcero
; Waclawovsky, Aline Josiane
; Pires, Daniel Alvarez
; Silva, Danilo Rodrigues Pereira da
; Jesus-Moraleida, Fabianna Resende de
; Moura, Helena Ferreira
; Coelho, Nicole Leite Galvão
; Monteiro-Junior, Renato Sobral
; Matias, Thiago Sousa
; Schuch, Felipe Barreto
; Deslandes, Andrea Camaz
.














ABSTRACT OBJECTIVE: To explore the associations between current mental health symptoms and social disparities in university students. METHODS: We recruited participants from nine public universities in Brazil, from August to November 2022, using online advertisements and in-person lectures. All participants completed an online survey containing social (sex, race/color, gender identity, sexual orientation, and income) and mental health assessments. The Jeopardy index was composed of social variables. The index considered zero points for subjects with less oppressive experienced characteristics (men, White, cisgender, heterosexual, higher income) and one point for the opposite characteristics. We defined six clusters according to Jeopardy Index results: 0, 1, 2, 3, 4, and 5 points, with the greatest number of points representing the most disadvantaged group. The mental health symptoms were assessed on two levels. First by the “DSM-5 Self-Rated Level 1 Cross-Cutting Symptom Measure – Adult,” and second by the “Patient Health Questionnaire-9,” and the “Generalized Anxiety Disorder Questionnaire-7.” Adjusted Odds Ratio (OR) analyses was performed for age and educational level. RESULTS: 748 participants were allocated into the six Jeopardy clusters: 0 (n = 46; 6.1%), 1 (n = 112; 15.0%), 2 (n = 163; 21.8%), 3 (n = 218; 29.1%), 4 (n = 171; 22.9%), and 5 (n = 38; 5.1%). It was observed a high prevalence of anxiety (42.5%) and depression (51.0%), however, the less privileged group (5) had a higher risk of having severe symptoms of anxiety (OR = 6.21; 1.51–25.58; p < 0.01) and depression (OR = 8.60; 2.15–34.43; p < 0.01), compared against the most privileged group. CONCLUSION: Although anxiety and depressive symptoms were highly prevalent for all participants, these disorders are not equally distributed in this population and the intersectionality between social factors plays an important role in contributing to these differences.
3.
Quality, bioactive compounds and enzymatic metabolism of cv. Vitoria pineapple during Maturation
Facebook Twitter

Facebook Twitter
- Other social networks
- Google+
- StambleUpon
- CiteULike
- Mendeley
- Other networks
- Metrics
Nascimento, Ricardo de Sousa
; Silva, Silvanda de Melo
; Sousa, Alex Sandro Bezerra de
; Silva, Mariany Cruz Alves da
; Lima, Renato Pereira
; Guimarães, George Henrique Camêlo
; Mendonça, Rejane Maria Nunes
; Rodrigues, Edileide Natália da Silva
.








ABSTRACT Pineapple is a non-climacteric infructescence that needs to be harvested at the highest quality, and it is crucial to determine the ideal harvest point. This work evaluates changes in quality, bioactive compounds, expression and enzymatic activity and antioxidant metabolism during maturation of cv Vitória pineapple, recently introduced in commercial orchards, in order to define the harvest point. ‘Vitória’ pineapple infructescence were harvested from commercial planting in five maturity stages and five replications: 100% green (TG), break (B), 75% green and 25% orange (GO), 25% green and 75% orange (OG), 10% green and 90% orange (PO), and 100% orange (TO). In ‘Vitória’ pineapple during maturation, color evolution was clearly shown by the color index (CI) and firmness was higher in TG, G, BP stages. Soluble solids and titratable acidity increased as a function of the maturity stages. The ascorbic acid content was higher in the TG and G, while the yellow flavonoids, PET, and carotenoids higher from OG to PO maturity stages. Antioxidant activity by ABTS•+ and DDPH radicals were higher in the PO stage. The moleculr weight of the antioxidant enzymes regardless the maturity stages was estimated at 47 kDa POD, 28 kDa SOD, and 37 kDa APX. By gel electrophoresis, the SOD, APX, and POD accumulations were higher at earlier maturity stages, whereas the activities were higher at the TO maturity stage. Altogether, the highest quality and functional properties in ‘Vitória’ pineapple, as defined by the highest contents of bioactive compounds and higher antioxidant, activity, were found mainly in the maturity stage PO, which surely value fresh consumption.
4.
Modelagem GAMLSS espaçotemporal da incidência de esquistossomose na região central do Estado de Minas Gerais, Brasil
Facebook Twitter

Facebook Twitter
- Other social networks
- Google+
- StambleUpon
- CiteULike
- Mendeley
- Other networks
- Metrics
Nogueira, Denismar Alves
; Sáfadi, Thelma
; Lima, Renato Ribeiro de
; Mata, Angélica Sousa da
; Graciano, Miriam Monteiro de Castro
; Barçante, Joziana Muniz de Paiva
; Barçante, Thales Augusto
; Dourado, Stela Márcia Pereira
.








Abstract: In Brazil, millions of people live in areas with risk of schistosomiasis, a neglected chronic disease with high morbidity. The Schistosoma mansoni helminth is present in all macroregions of Brazil, including the State of Minas Gerais, one of the most endemic states. For this reason, the identification of potential foci is essential to support educational and prophylactic public policies to control this disease. This study aims to model schistosomiasis data based on spatial and temporal aspects and assess the importance of some exogenous socioeconomic variables and the presence of the main Biomphalaria species. Considering that, when working with incident cases, a discrete count variable requires an appropriate modeling, the GAMLSS modeling was chosen since it jointly considers a more appropriate distribution for the response variable due to zero inflation and spatial heteroscedasticity. Several municipalities presented high incidence values from 2010 to 2012, and a downward trend was observed until 2020. We also noticed that the distribution of incidence behaves differently in space and time. Municipalities with dams presented risk 2.25 times higher than municipalities without dams. The presence of B. glabrata was associated with the risk of schistosomiasis. On the other hand, the presence of B. straminea represented a lower risk of the disease. Thus, the control and monitoring of B. glabrata snails is essential to control and eliminate schistosomiasis; and the GAMLSS model was effective in the treatment and modeling of spatio-temporal data.
Resumo: No Brasil, milhões de pessoas vivem em áreas de risco para a esquistossomose, uma doença negligenciada, de caráter crônico e com elevada morbidade. O helminto Schistosoma mansoni está presente em todas as macrorregiões, incluindo o Estado de Minas Gerais, um dos mais endêmicos. Por essa razão, a identificação de potenciais focos é fundamental para subsidiar políticas públicas de cunho educativo e profilático no controle desse desfecho. Nesse contexto, o objetivo do trabalho consiste em modelar dados de esquistossomose em relação aos aspectos espaciais e temporais, além de avaliar a importância de algumas variáveis exógenas socioeconômicas e a presença das principais espécies de Biomphalaria. Como trabalhar com casos incidentes, uma variável discreta de contagem, exige uma modelagem apropriada, foi escolhida a modelagem GAMLSS por considerar conjuntamente uma distribuição mais adequada à variável resposta devido à inflação de zeros e à heterocedasticidade espacial. Verificaram-se valores elevados de incidência em diversos municípios de 2010 a 2012 e uma tendência de queda até 2020. Também foi identificado que a distribuição da incidência se comporta de maneira diferente no espaço e no tempo. Municípios com barragem apresentaram risco 2,25 vezes maior do que os que não a continham. A presença de B. glabrata foi relacionada ao risco de ocorrência da doença. Por outro lado, a presença de B. straminea refletiu em menor risco de ocorrência da esquistossomose. Conclui-se que o controle e o acompanhamento dos caramujos da B. glabrata podem ser fundamentais para a contenção e a eliminação da esquistossomose e o modelo GAMLSS foi eficaz para tratamento e modelagem de dados espaçotemporais.
Resumen: En Brasil, millones de personas viven en áreas de riesgo de esquistosomiasis, una enfermedad crónica desatendida y con alta morbilidad. El helminto Schistosoma mansoni está presente en todas las macrorregiones, incluido el Estado de Minas Gerais, uno de los más endémicos del país. Por ello, la identificación de potenciales brotes es fundamental para promover políticas públicas de carácter educativo y profiláctico en el control de este desenlace. En este contexto, el objetivo de este trabajo es modelar datos sobre esquistosomiasis con respecto a aspectos espaciotemporales, además de evaluar la importancia de algunas variables socioeconómicas exógenas y la presencia de las principales especies de Biomphalaria. Dado que en el trabajo con casos incidentes una variable de conteo discreta requiere un adecuado modelado, se eligió el modelo GAMLSS, ya que en conjunto considera una distribución más adecuada para la variable de respuesta debido a la inflación de ceros y la heterocedasticidad espacial. Se encontraron valores de alta incidencia en varios municipios en el periodo evaluado de 2010 a 2012 y una tendencia a descenso hasta 2020. También se verificó que existe una distribución de incidencia de manera diferente en el espacio y el tiempo. Los municipios con represas presentaban 2,25 veces más riesgo que los que no las tenían. La presencia de B. glabrata estuvo relacionada con el riesgo de la enfermedad. Por otro lado, la presencia de B. straminea ocasionaba un menor riesgo de padecer la enfermedad. Se concluye que el control y seguimiento de caracoles B. glabrata puede ser fundamental para el control y eliminación de la esquistosomiasis y que el modelo GAMLSS resultó ser efectivo para el tratamiento y modelado de datos espaciotemporales.
5.
Modelagem GAMLSS espaçotemporal da incidência de esquistossomose na região central do Estado de Minas Gerais, Brasil
Facebook Twitter

Facebook Twitter
- Other social networks
- Google+
- StambleUpon
- CiteULike
- Mendeley
- Other networks
- Metrics
Nogueira, Denismar Alves
; Sáfadi, Thelma
; Lima, Renato Ribeiro de
; Mata, Angélica Sousa da
; Graciano, Miriam Monteiro de Castro
; Barçante, Joziana Muniz de Paiva
; Barçante, Thales Augusto
; Dourado, Stela Márcia Pereira
.








Resumo: No Brasil, milhões de pessoas vivem em áreas de risco para a esquistossomose, uma doença negligenciada, de caráter crônico e com elevada morbidade. O helminto Schistosoma mansoni está presente em todas as macrorregiões, incluindo o Estado de Minas Gerais, um dos mais endêmicos. Por essa razão, a identificação de potenciais focos é fundamental para subsidiar políticas públicas de cunho educativo e profilático no controle desse desfecho. Nesse contexto, o objetivo do trabalho consiste em modelar dados de esquistossomose em relação aos aspectos espaciais e temporais, além de avaliar a importância de algumas variáveis exógenas socioeconômicas e a presença das principais espécies de Biomphalaria. Como trabalhar com casos incidentes, uma variável discreta de contagem, exige uma modelagem apropriada, foi escolhida a modelagem GAMLSS por considerar conjuntamente uma distribuição mais adequada à variável resposta devido à inflação de zeros e à heterocedasticidade espacial. Verificaram-se valores elevados de incidência em diversos municípios de 2010 a 2012 e uma tendência de queda até 2020. Também foi identificado que a distribuição da incidência se comporta de maneira diferente no espaço e no tempo. Municípios com barragem apresentaram risco 2,25 vezes maior do que os que não a continham. A presença de B. glabrata foi relacionada ao risco de ocorrência da doença. Por outro lado, a presença de B. straminea refletiu em menor risco de ocorrência da esquistossomose. Conclui-se que o controle e o acompanhamento dos caramujos da B. glabrata podem ser fundamentais para a contenção e a eliminação da esquistossomose e o modelo GAMLSS foi eficaz para tratamento e modelagem de dados espaçotemporais.
Resumen: En Brasil, millones de personas viven en áreas de riesgo de esquistosomiasis, una enfermedad crónica desatendida y con alta morbilidad. El helminto Schistosoma mansoni está presente en todas las macrorregiones, incluido el Estado de Minas Gerais, uno de los más endémicos del país. Por ello, la identificación de potenciales brotes es fundamental para promover políticas públicas de carácter educativo y profiláctico en el control de este desenlace. En este contexto, el objetivo de este trabajo es modelar datos sobre esquistosomiasis con respecto a aspectos espaciotemporales, además de evaluar la importancia de algunas variables socioeconómicas exógenas y la presencia de las principales especies de Biomphalaria. Dado que en el trabajo con casos incidentes una variable de conteo discreta requiere un adecuado modelado, se eligió el modelo GAMLSS, ya que en conjunto considera una distribución más adecuada para la variable de respuesta debido a la inflación de ceros y la heterocedasticidad espacial. Se encontraron valores de alta incidencia en varios municipios en el periodo evaluado de 2010 a 2012 y una tendencia a descenso hasta 2020. También se verificó que existe una distribución de incidencia de manera diferente en el espacio y el tiempo. Los municipios con represas presentaban 2,25 veces más riesgo que los que no las tenían. La presencia de B. glabrata estuvo relacionada con el riesgo de la enfermedad. Por otro lado, la presencia de B. straminea ocasionaba un menor riesgo de padecer la enfermedad. Se concluye que el control y seguimiento de caracoles B. glabrata puede ser fundamental para el control y eliminación de la esquistosomiasis y que el modelo GAMLSS resultó ser efectivo para el tratamiento y modelado de datos espaciotemporales.
Abstract: In Brazil, millions of people live in areas with risk of schistosomiasis, a neglected chronic disease with high morbidity. The Schistosoma mansoni helminth is present in all macroregions of Brazil, including the State of Minas Gerais, one of the most endemic states. For this reason, the identification of potential foci is essential to support educational and prophylactic public policies to control this disease. This study aims to model schistosomiasis data based on spatial and temporal aspects and assess the importance of some exogenous socioeconomic variables and the presence of the main Biomphalaria species. Considering that, when working with incident cases, a discrete count variable requires an appropriate modeling, the GAMLSS modeling was chosen since it jointly considers a more appropriate distribution for the response variable due to zero inflation and spatial heteroscedasticity. Several municipalities presented high incidence values from 2010 to 2012, and a downward trend was observed until 2020. We also noticed that the distribution of incidence behaves differently in space and time. Municipalities with dams presented risk 2.25 times higher than municipalities without dams. The presence of B. glabrata was associated with the risk of schistosomiasis. On the other hand, the presence of B. straminea represented a lower risk of the disease. Thus, the control and monitoring of B. glabrata snails is essential to control and eliminate schistosomiasis; and the GAMLSS model was effective in the treatment and modeling of spatio-temporal data.
6.
Samanea tubulosa Benth. (Fabaceae): Antinociceptive effect on acute pain in mice: K+ATP channel and opioid activity
Facebook Twitter

Facebook Twitter
- Other social networks
- Google+
- StambleUpon
- CiteULike
- Mendeley
- Other networks
- Metrics
ALIXANDRE, TAMNATA F.
; SOUSA, RENATO P.
; GOMES, BRUNO S.
; SILVA, ARÊTHA H.S.
; SOUSA NETO, BENEDITO P.
; SOUSA, ELCILENE A.
; LIMA, MARLUCE P.D.
; LOPES, EVERTON M.
; PIAUILINO, CELYANE A.
; NASCIMENTO, REJANE T.
; REIS FILHO, ANTÔNIO C.
; ALMEIDA, FERNANDA R.C.
; OLIVEIRA, FRANCISCO A.
; CHAVES, MARIANA H.
; COSTA, LUCIANA M.
; ALVES, MICHEL M. MORAES
; COSTA, AMILTON P.R.
.

















Abstract Samanea tubulosa Benth. it has been widely used in traditional medicine to treat inflammatory processes. The present study aimed to investigate the antinociceptive effect and mechanism of action of the fractions obtained from the Samanea tubulosa pods in mice. The antinociceptive activity was evaluated in formalin, capsaicin and glutamate tests and the. The possible mechanisms of action involved in the antinociceptive effect of the hexane and ethyl acetate fraction in the opioid system, also the the K + ATP channels and the L-arigine pathways of nitric oxide were evaluated. The chemical characterization analysis revealed in the hexane fraction the presence of triterpenes such as lupenone and lupeol. In the glutamate test, the hexane and ethyl acetate fractions showed antinociceptive activity at the dose of 12.5 and 25 mg kg-1. The antinociception produced by the hexane and ethyl acetate fractions was significantly reversed by naloxone, indicating that the fractions act through the opioid pathway. Antinociceptive response of the ethyl acetate fraction was blocked by glibenclamide, indicating that this fraction acts via the K + ATP channels activation. It is concluded that the fractions under study exert antinociceptive activity possibly related to the opioid route and through K+ ATP channels activation.
7.
SARS-CoV-2 and rhinovirus infections: are there differences in clinical presentation, laboratory abnormalities, and outcomes in the pediatric population?
Facebook Twitter

Facebook Twitter
- Other social networks
- Google+
- StambleUpon
- CiteULike
- Mendeley
- Other networks
- Metrics
Pereira, Maria Fernanda Bádue
; Suguita, Priscila
; Litvinov, Nadia
; Farhat, Sylvia Costa Lima
; Paula, Camila Sanson Yoshino de
; Lázari, Carolina dos Santos
; Bedê, Pedro Vale
; Framil, Juliana Valeria de Souza
; Bueno, Catarina
; Branas, Priscila Cristina Abduch Adas
; Guimarães, Irina Monteiro da Costa
; Leite, Marcia Marques
; Navega, Ana Carolina Barsaglini
; Nanbu, Danilo Yamamoto
; Schvartsman, Claudio
; Pinho, João Renato Rebello
; Silva, Clovis Artur Almeida
; Marques, Heloisa Helena de Sousa
; Eisencraft, Adriana Pasmanik
; Rossi Jr, Alfio
; Delgado, Artur Figueiredo
; Leal, Gabriela Nunes
; Gibelli, Maria Augusta Cicaroni
; Palmeira, Patricia
; Sakita, Neusa Keico
; Santos, Emilly Henrique dos
; Rocha, Mussya Cisotto
; Kanunfre, Kelly Aparecida
; Okay, Thelma Suely
; Carneiro-Sampaio, Magda
; Carvalho, Werther Brunow de






























Revista do Instituto de Medicina Tropical de São Paulo
- Journal Metrics
ABSTRACT This study aims to assess COVID-19 and other respiratory viruses in pediatric patients. Between April 17 and September 30, 2020, we collected 1,566 respiratory samples from 1,044 symptomatic patients who were younger than 18 years old to assess SARS-CoV-2 infection. Of these, 919 were analyzed for other respiratory pathogens (ORP). Patients with laboratory-confirmed COVID-19 or ORP were included. We evaluated 76 pediatric COVID-19 infections and 157 other respiratory virus infections. Rhinovirus occurred in 132/157 (84%). COVID-19 patients who were significantly older, had more fevers, headaches and pneumonia than those with ORP. The median white blood cell count was lower in patients with SARS-CoV-2 than in those with ORP (6,470 versus 8,170; p=0.02). COVID-19 patients had significantly worse symptoms than those with ORP.
8.
Technical performance of a lateral flow immunoassay for detection of anti-SARS-CoV-2 IgG in the outpatient follow-up of non-severe cases and at different times after vaccination: comparison with enzyme and chemiluminescent immunoassays
Facebook Twitter

Facebook Twitter
- Other social networks
- Google+
- StambleUpon
- CiteULike
- Mendeley
- Other networks
- Metrics
Barreira, Gabriel Acca
; Santos, Emilly Henrique dos
; Pereira, Maria Fernanda Bádue
; Rodrigues, Karen Alessandra
; Rocha, Mussya Cisotto
; Kanunfre, Kelly Aparecida
; Marques, Heloisa Helena de Sousa
; Okay, Thelma Suely
; Eisencraft, Adriana Pasmanik
Rossi Junior, Alfio
Fante, Alice Lima
Cora, Aline Pivetta
Costa Reis, Amelia Gorete A. de
Ferrer, Ana Paula Scoleze
Andrade, Anarella Penha Meirelles de
Watanabe, Andreia
Gonçalves, Angelina Maria Freire
Waetge, Aurora Rosaria Pagliara
Silva, Camila Altenfelder
Ceneviva, Carina
Lazari, Carolina dos Santos
Abellan, Deipara Monteiro
Sabino, Ester Cerdeira
Bianchini, Fabíola Roberta Marim
Alcantara, Flávio Ferraz de Paes
Ramos, Gabriel Frizzo
Leal, Gabriela Nunes
Rodriguez, Isadora Souza
Pinho, João Renato Rebello
Carneiro, Jorge David Avaizoglou
Paz, Jose Albino
Ferreira, Juliana Carvalho
Ferranti, Juliana Ferreira
Ferreira, Juliana de Oliveira Achili
Framil, Juliana Valéria de Souza
Silva, Katia Regina da
Bastos, Karina Lucio de Medeiros
Galleti, Karine Vusberg
Cristofani, Lilian Maria
Suzuki, Lisa
Campos, Lucia Maria Arruda
Perondi, Maria Beatriz de Moliterno
Diniz, Maria de Fatima Rodrigues
Fonseca, Maria Fernanda Mota
Cordon, Mariana Nutti de Almeida
Pissolato, Mariana
Peres, Marina Silva
Garanito, Marlene Pereira
Imamura, Marta
Dorna, Mayra de Barros
Luglio, Michele
Aikawa, Nadia Emi
Degaspare, Natalia Viu
Sakita, Neusa Keico
Udsen, Nicole Lee
Scudeller, Paula Gobi
Gaiolla, Paula Vieira de Vincenzi
Severini, Rafael da Silva Giannasi
Rodrigues, Regina Maria
Toma, Ricardo Katsuya
Paula, Ricardo Iunis Citrangulo de
Palmeira, Patricia
Forsait, Silvana
Farhat, Sylvia Costa Lima
Sakano, Tânia Miyuki Shimoda
Koch, Vera Hermina Kalika
Cobello Junior, Vilson








Revista do Instituto de Medicina Tropical de São Paulo
- Journal Metrics
ABSTRACT This study assessed the technical performance of a rapid lateral flow immunochromatographic assay (LFIA) for the detection of anti-SARS-CoV-2 IgG and compared LFIA results with chemiluminescent immunoassay (CLIA) results and an in-house enzyme immunoassay (EIA). To this end, a total of 216 whole blood or serum samples from three groups were analyzed: the first group was composed of 68 true negative cases corresponding to blood bank donors, healthy young volunteers, and eight pediatric patients diagnosed with other coronavirus infections. The serum samples from these participants were obtained and stored in a pre-COVID-19 period, thus they were not expected to have COVID-19. In the second group of true positive cases, we chose to replace natural cases of COVID-19 by 96 participants who were expected to have produced anti-SARS-CoV-2 IgG antibodies 30-60 days after the vaccine booster dose. The serum samples were collected on the same day that LFIA were tested either by EIA or CLIA. The third study group was composed of 52 participants (12 adults and 40 children) who did or did not have anti-SARS-CoV-2 IgG antibodies due to specific clinical scenarios. The 12 adults had been vaccinated more than seven months before LFIA testing, and the 40 children had non-severe COVID-19 diagnosed using RT-PCR during the acute phase of infection. They were referred for outpatient follow-up and during this period the serum samples were collected and tested by CLIA and LFIA. All tests were performed by the same healthcare operator and there was no variation of LFIA results when tests were performed on finger prick whole blood or serum samples, so that results were grouped for analysis. LFIA’s sensitivity in detecting anti-SARS-CoV-2 IgG antibodies was 90%, specificity 97.6%, efficiency 93%, PPV 98.3%, NPV 86.6%, and likelihood ratio for a positive or a negative result were 37.5 and 0.01 respectively. There was a good agreement (Kappa index of 0.677) between LFIA results and serological (EIA or CLIA) results. In conclusion, LFIA analyzed in this study showed a good technical performance and agreement with reference serological assays (EIA or CLIA), therefore it can be recommended for use in the outpatient follow-up of non-severe cases of COVID-19 and to assess anti-SARS-CoV-2 IgG antibody production induced by vaccination and the antibodies decrease over time. However, LFIAs should be confirmed by using reference serological assays whenever possible.
9.
Survival of atraumatic restorative treatment restorations in the elderly patients: a systematic review
Facebook Twitter

Facebook Twitter
- Other social networks
- Google+
- StambleUpon
- CiteULike
- Mendeley
- Other networks
- Metrics
Maia, Thaís Souza
; Lima, Thamires Diogo
; Vieira, Walbert de Andrade
; Blumenberg, Cauane
; Agostini, Bernardo Antonio
; Nascimento, Gustavo Giacomelli
; Paranhos, Luiz Renato
; Menezes, Murilo de Sousa
.








Abstract: This study aimed to assess the survival of glass ionomer cement (GIC) restorations performed using the atraumatic restorative treatment (ART) in elderly patients. The systematic review protocol was registered in the PROSPERO database. The records were searched until August 2020 in eight electronic bibliographic databases, and included randomized and non-randomized clinical trials and observational studies, with no restrictions on the language or year of publication. Study selection and data extraction were performed independently by two reviewers. Data were extracted, summarized, collected for qualitative analysis, and evaluated for individual risk of bias using the Joanna Briggs Institute's Critical Appraisal Tool. The literature search retrieved 5,186 records; however, only seven studies fulfilled the eligibility criteria and were included. The studies were published between 2002 and 2019. A total of 1,239 restorations were investigated at intervals of 6, 12, 24, and 60 months of follow-up. Some studies had a low risk of bias, while others had moderate and high risk of bias. In general, GIC restorations placed using ART were considered satisfactory. The 6-month, 12-month, and 24-month survival rates ranged from 81.3% to 97.2%, 72.2% to 94%, and 63% to 87%, respectively; additionally, the survival rate for the longest follow-up period (60 months) was 85%. Given the best evidence-based information regarding caries removal, we highlight the need to provide a conservative and effective technique for use in elderly patients. ART is a promising and viable alternative that guarantees the survival of restorations in elderly patients.
10.
Differences in children and adolescents with SARS-CoV-2 infection: a cohort study in a Brazilian tertiary referral hospital
Facebook Twitter

Facebook Twitter
- Other social networks
- Google+
- StambleUpon
- CiteULike
- Mendeley
- Other networks
- Metrics
Marques, Heloisa Helena de Sousa
; Pereira, Maria Fernanda Badue
; Santos, Angélica Carreira dos
; Fink, Thais Toledo
; Paula, Camila Sanson Yoshino de
; Litvinov, Nadia
; Schvartsman, Claudio
; Delgado, Artur Figueiredo
; Gibelli, Maria Augusta Bento Cicaroni
; Carvalho, Werther Brunow de
; Odone Filho, Vicente
; Tannuri, Uenis
; Carneiro-Sampaio, Magda
; Grisi, Sandra
; Duarte, Alberto José da Silva
; Antonangelo, Leila
; Francisco, Rossana Pucineli Vieira
; Okay, Thelma Suely
; Batisttella, Linamara Rizzo
; Carvalho, Carlos Roberto Ribeiro de
; Brentani, Alexandra Valéria Maria
; Silva, Clovis Artur
; Eisencraft, Adriana Pasmanik
Rossi Junior, Alfio
Fante, Alice Lima
Cora, Aline Pivetta
Reis, Amelia Gorete A. de Costa
Ferrer, Ana Paula Scoleze
Andrade, Anarella Penha Meirelles de
Watanabe, Andreia
Gonçalves, Angelina Maria Freire
Waetge, Aurora Rosaria Pagliara
Silva, Camila Altenfelder
Ceneviva, Carina
Lazari, Carolina dos Santos
Abellan, Deipara Monteiro
Santos, Emilly Henrique dos
Sabino, Ester Cerdeira
Bianchini, Fabíola Roberta Marim
Alcantara, Flávio Ferraz de Paes
Ramos, Gabriel Frizzo
Leal, Gabriela Nunes
Rodriguez, Isadora Souza
Pinho, João Renato Rebello
Carneiro, Jorge David Avaizoglou
Paz, Jose Albino
Ferreira, Juliana Carvalho
Ferranti, Juliana Ferreira
Ferreira, Juliana de Oliveira Achili
Framil, Juliana Valéria de Souza
Silva, Katia Regina da
Kanunfre, Kelly Aparecida
Bastos, Karina Lucio de Medeiros
Galleti, Karine Vusberg
Cristofani, Lilian Maria
Suzuki, Lisa
Campos, Lucia Maria Arruda
Perondi, Maria Beatriz de Moliterno
Diniz, Maria de Fatima Rodrigues
Fonseca, Maria Fernanda Mota
Cordon, Mariana Nutti de Almeida
Pissolato, Mariana
Peres, Marina Silva
Garanito, Marlene Pereira
Imamura, Marta
Dorna, Mayra de Barros
Luglio, Michele
Rocha, Mussya Cisotto
Aikawa, Nadia Emi
Degaspare, Natalia Viu
Sakita, Neusa Keico
Udsen, Nicole Lee
Scudeller, Paula Gobi
Gaiolla, Paula Vieira de Vincenzi
Severini, Rafael da Silva Giannasi
Rodrigues, Regina Maria
Toma, Ricardo Katsuya
Paula, Ricardo Iunis Citrangulo de
Palmeira, Patricia
Forsait, Silvana
Farhat, Sylvia Costa Lima
Sakano, Tânia Miyuki Shimoda
Koch, Vera Hermina Kalika
Cobello Junior, Vilson






















OBJECTIVES: To compare demographic/clinical/laboratory/treatments and outcomes among children and adolescents with laboratory-confirmed coronavirus disease 2019 (COVID-19). METHODS: This was a cross-sectional study that included patients diagnosed with pediatric COVID-19 (aged <18 years) between April 11, 2020 and April 22, 2021. During this period, 102/5,951 (1.7%) of all admissions occurred in neonates, children, and adolescents. Furthermore, 3,962 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) detection samples were processed in patients aged <18 years, and laboratory-confirmed COVID-19 occurred in 155 (4%) inpatients and outpatients. Six/155 pediatric patients were excluded from the study. Therefore, the final group included 149 children and adolescents (n=97 inpatients and 52 outpatients) with positive SARS-CoV-2 results. RESULTS: The frequencies of sore throat, anosmia, dysgeusia, headache, myalgia, nausea, lymphopenia, pre-existing chronic conditions, immunosuppressive conditions, and autoimmune diseases were significantly reduced in children and adolescents (p<0.05). Likewise, the frequencies of enoxaparin use (p=0.037), current immunosuppressant use (p=0.008), vasoactive agents (p=0.045), arterial hypotension (p<0.001), and shock (p=0.024) were significantly lower in children than in adolescents. Logistic regression analysis showed that adolescents with laboratory-confirmed COVID-19 had increased odds ratios (ORs) for sore throat (OR 13.054; 95% confidence interval [CI] 2.750-61.977; p=0.001), nausea (OR 8.875; 95% CI 1.660-47.446; p=0.011), and lymphopenia (OR 3.575; 95% CI 1.355-9.430; p=0.010), but also had less hospitalizations (OR 0.355; 95% CI 0.138-0.916; p=0.032). The additional logistic regression analysis on patients with preexisting chronic conditions (n=108) showed that death as an outcome was significantly associated with pediatric severe acute respiratory syndrome (SARS) (OR 22.300; 95% CI 2.341-212.421; p=0.007) and multisystem inflammatory syndrome in children (MIS-C) (OR 11.261; 95% CI 1.189-106. 581; p=0.035). CONCLUSIONS: Half of the laboratory-confirmed COVID-19 cases occurred in adolescents. Individuals belonging to this age group had an acute systemic involvement of SARS-CoV-2 infection. Pediatric SARS and MIS-C were the most important factors associated with the mortality rate in pediatric chronic conditions with COVID-19.
11.
Epidemiologia e desfecho dos pacientes de alto risco cirúrgico admitidos em unidades de terapia intensiva no Brasil
Facebook Twitter

Facebook Twitter
- Other social networks
- Google+
- StambleUpon
- CiteULike
- Mendeley
- Other networks
- Metrics
Silva Júnior, João Manoel
; Chaves, Renato Carneiro de Freitas
; Corrêa, Thiago Domingos
; Assunção, Murillo Santucci Cesar de
; Katayama, Henrique Tadashi
; Bosso, Fabio Eduardo
; Amendola, Cristina Prata
; Serpa Neto, Ary
; Malbouisson, Luiz Marcelo Sá
; Oliveira, Neymar Elias de
; Veiga, Viviane Cordeiro
Rojas, Salomón Soriano Ordinola
Postalli, Natalia Fioravante
Alvarisa, Thais Kawagoe
Lucena, Bruno Melo Nobrega de
Oliveira, Raphael Augusto Gomes de
Sanches, Luciana Coelho
Silva, Ulysses Vasconcellos de Andrade e
Nassar Junior, Antonio Paulo
Réa-Neto, Álvaro
Amaral, Alexandre
Teles, José Mário
Freitas, Flávio Geraldo Rezende de
Bafi, Antônio Tonete
Pacheco, Eduardo Souza
Ramos, Fernando José
Vieira Júnior, José Mauro
Pereira, Maria Augusta Santos Rahe
Schwerz, Fábio Sartori
Menezes, Giovanna Padoa de
Magalhães, Danielle Dourado
Castro, Cristine Pilati Pileggi
Henrich, Sabrina Frighetto
Toledo, Diogo Oliveira
Parra, Bruna Fernanda Camargo Silva
Dias, Fernando Suparregui
Zerman, Luiza
Formolo, Fernanda
Nobrega, Marciano de Sousa
Piras, Claudio
Piras, Stéphanie de Barros
Conti, Rodrigo
Bittencourt, Paulo Lisboa
D’Oliveira, Ricardo Azevedo Cruz
Estrela, André Ricardo de Oliveira
Oliveira, Mirella Cristine de
Reese, Fernanda Baeumle
Motta Júnior, Jarbas da Silva
Câmara, Bruna Martins Dzivielevski da
David-João, Paula Geraldes
Tannous, Luana Alves
Chaiben, Viviane Bernardes de Oliveira
Miranda, Lorena Macedo Araújo
Brasil, José Arthur dos Santos
Deucher, Rafael Alexandre de Oliveira
Ferreira, Marcos Henrique Borges
Vilela, Denner Luiz
Almeida, Guilherme Cincinato de
Nedel, Wagner Luis
Passos, Matheus Golenia dos
Marin, Luiz Gustavo
Oliveira Filho, Wilson de
Coutinho, Raoni Machado
Oliveira, Michele Cristina Lima de
Friedman, Gilberto
Meregalli, André
Höher, Jorge Amilton
Soares, Afonso José Celente
Lobo, Suzana Margareth Ajeje










RESUMO Objetivo: Definir o perfil epidemiológico e os principais determinantes de morbimortalidade dos pacientes cirúrgicos não cardíacos de alto risco no Brasil. Métodos: Estudo prospectivo, observacional e multicêntrico. Todos os pacientes cirúrgicos não cardíacos admitidos nas unidades de terapia intensiva, ou seja, considerados de alto risco, no período de 1 mês, foram avaliados e acompanhados diariamente por, no máximo, 7 dias na unidade de terapia intensiva, para determinação de complicações. As taxas de mortalidade em 28 dias de pós-operatório, na unidade de terapia intensiva e hospitalar foram avaliadas. Resultados: Participaram 29 unidades de terapia intensiva onde foram realizadas cirurgias em 25.500 pacientes, dos quais 904 (3,5%) de alto risco (intervalo de confiança de 95% - IC95% 3,3% - 3,8%), tendo sido incluídos no estudo. Dos pacientes envolvidos, 48,3% eram de unidades de terapia intensiva privadas e 51,7% de públicas. O tempo de internação na unidade de terapia intensiva foi de 2,0 (1,0 - 4,0) dias e hospitalar de 9,5 (5,4 - 18,6) dias. As taxas de complicações foram 29,9% (IC95% 26,4 - 33,7) e mortalidade em 28 dias pós-cirurgia 9,6% (IC95% 7,4 - 12,1). Os fatores independentes de risco para complicações foram Simplified Acute Physiology Score 3 (SAPS 3; razão de chance − RC = 1,02; IC95% 1,01 - 1,03) e Sequential Organ Failure Assessment Score (SOFA) da admissão na unidade de terapia intensiva (RC =1,17; IC95% 1,09 - 1,25), tempo de cirurgia (RC = 1,001; IC95% 1,000 - 1,002) e cirurgias de emergências (RC = 1,93; IC95% 1,10 - 3,38). Em adição, foram associados com mortalidade em 28 dias idade (RC = 1,032; IC95% 1,011 - 1,052) SAPS 3 (RC = 1,041; IC95% 1,107 - 1,279), SOFA (RC = 1,175; IC95% 1,069 - 1,292) e cirurgias emergenciais (RC = 2,509; IC95% 1,040 - 6,051). Conclusão: Pacientes com escores prognósticos mais elevados, idosos, tempo cirúrgico e cirurgias emergenciais estiveram fortemente associados a maior mortalidade em 28 dias e mais complicações durante permanência em unidade de terapia intensiva.
ABSTRACT Objective: To define the epidemiological profile and the main determinants of morbidity and mortality in noncardiac high surgical risk patients in Brazil. Methods: This was a prospective, observational and multicenter study. All noncardiac surgical patients admitted to intensive care units, i.e., those considered high risk, within a 1-month period were evaluated and monitored daily for a maximum of 7 days in the intensive care unit to determine complications. The 28-day postoperative, intensive care unit and hospital mortality rates were evaluated. Results: Twenty-nine intensive care units participated in the study. Surgeries were performed in 25,500 patients, of whom 904 (3.5%) were high-risk (95% confidence interval - 95%CI 3.3% - 3.8%) and were included in the study. Of the participating patients, 48.3% were from private intensive care units, and 51.7% were from public intensive care units. The length of stay in the intensive care unit was 2.0 (1.0 - 4.0) days, and the length of hospital stay was 9.5 (5.4 - 18.6) days. The complication rate was 29.9% (95%CI 26.4 - 33.7), and the 28-day postoperative mortality rate was 9.6% (95%CI 7.4 - 12.1). The independent risk factors for complications were the Simplified Acute Physiology Score 3 (SAPS 3; odds ratio - OR = 1.02; 95%CI 1.01 - 1.03) and Sequential Organ Failure Assessment Score (SOFA) on admission to the intensive care unit (OR = 1.17; 95%CI 1.09 - 1.25), surgical time (OR = 1.001, 95%CI 1.000 - 1.002) and emergency surgeries (OR = 1.93, 95%CI, 1.10 - 3.38). In addition, there were associations with 28-day mortality (OR = 1.032; 95%CI 1.011 - 1.052), SAPS 3 (OR = 1.041; 95%CI 1.107 - 1.279), SOFA (OR = 1.175, 95%CI 1.069 - 1.292) and emergency surgeries (OR = 2.509; 95%CI 1.040 - 6.051). Conclusion: Higher prognostic scores, elderly patients, longer surgical times and emergency surgeries were strongly associated with higher 28-day mortality and more complications during the intensive care unit stay.
https://doi.org/10.5935/0103-507x.20200005
1048 downloads
12.
Severe clinical spectrum with high mortality in pediatric patients with COVID-19 and multisystem inflammatory syndrome
Facebook Twitter

Facebook Twitter
- Other social networks
- Google+
- StambleUpon
- CiteULike
- Mendeley
- Other networks
- Metrics
Pereira, Maria Fernanda Badue
; Litvinov, Nadia
; Farhat, Sylvia Costa Lima
; Eisencraft, Adriana Pasmanik
; Gibelli, Maria Augusta Bento Cicaroni
; Carvalho, Werther Brunow de
Fernandes, Vinicius Rodrigues
Fink, Thais de Toledo
Framil, Juliana Valéria de Souza
Galleti, Karine Vusberg
Fante, Alice Lima
Fonseca, Maria Fernanda Mota
Watanabe, Andreia
Paula, Camila Sanson Yoshino de
Palandri, Giovanna Gavros
Leal, Gabriela Nunes
Diniz, Maria de Fatima Rodrigues
Pinho, João Renato Rebello
Silva, Clovis Artur
Marques, Heloisa Helena de Sousa
Rossi Junior, Alfio
Delgado, Artur Figueiredo
Andrade, Anarella Penha Meirelles de
Schvartsman, Claudio
Sabino, Ester Cerdeira
Rocha, Mussya Cisotto
Kanunfre, Kelly Aparecida
Okay, Thelma Suely
Carneiro-Sampaio, Magda Maria Sales
Jorge, Patricia Palmeira Daenekas





OBJECTIVES: To assess the outcomes of pediatric patients with laboratory-confirmed coronavirus disease (COVID-19) with or without multisystem inflammatory syndrome in children (MIS-C). METHODS: This cross-sectional study included 471 samples collected from 371 patients (age<18 years) suspected of having severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. The study group comprised 66/371 (18%) laboratory-confirmed pediatric COVID-19 patients: 61 (92.5%) patients tested positive on real-time reverse transcription-polymerase chain reaction tests for SARS-CoV-2, and 5 (7.5%) patients tested positive on serological tests. MIS-C was diagnosed according to the criteria of the Center for Disease Control. RESULTS: MIS-C was diagnosed in 6/66 (9%) patients. The frequencies of diarrhea, vomiting, and/or abdominal pain (67% vs. 22%, p=0.034); pediatric SARS (67% vs. 13%, p=0.008); hypoxemia (83% vs. 23%, p=0.006); and arterial hypotension (50% vs. 3%, p=0.004) were significantly higher in patients with MIS-C than in those without MIS-C. The frequencies of C-reactive protein levels >50 mg/L (83% vs. 25%, p=0.008) and D-dimer levels >1000 ng/mL (100% vs. 40%, p=0.007) and the median D-dimer, troponin T, and ferritin levels (p<0.05) were significantly higher in patients with MIS-C. The frequencies of pediatric intensive care unit admission (100% vs. 60%, p=0.003), mechanical ventilation (83% vs. 7%, p<0.001), vasoactive agent use (83% vs. 3%, p<0.001), shock (83% vs. 5%, p<0.001), cardiac abnormalities (100% vs. 2%, p<0.001), and death (67% vs. 3%, p<0.001) were also significantly higher in patients with MIS-C. Similarly, the frequencies of oxygen therapy (100% vs. 33%, p=0.003), intravenous immunoglobulin therapy (67% vs. 2%, p<0.001), aspirin therapy (50% vs. 0%, p<0.001), and current acute renal replacement therapy (50% vs. 2%, p=0.002) were also significantly higher in patients with MIS-C. Logistic regression analysis showed that the presence of MIS-C was significantly associated with gastrointestinal manifestations [odds ratio (OR)=10.98; 95%CI (95% confidence interval)=1.20-100.86; p=0.034] and hypoxemia [OR=16.85; 95%CI=1.34-211.80; p=0.029]. Further univariate analysis showed a positive association between MIS-C and death [OR=58.00; 95%CI=6.39-526.79; p<0.0001]. CONCLUSIONS: Pediatric patients with laboratory-confirmed COVID-19 with MIS-C had a severe clinical spectrum with a high mortality rate. Our study emphasizes the importance of investigating MIS-C in pediatric patients with COVID-19 presenting with gastrointestinal involvement and hypoxemia.
https://doi.org/10.6061/clinics/2020/e2209
2260 downloads
13.
Characteristics and outcomes of patients with COVID-19 admitted to the ICU in a university hospital in São Paulo, Brazil - study protocol
Facebook Twitter

Facebook Twitter
- Other social networks
- Google+
- StambleUpon
- CiteULike
- Mendeley
- Other networks
- Metrics
Ferreira, Juliana C.
; Ho, Yeh-Li
; Besen, Bruno A.M.P.
; Malbuisson, Luiz M.S.
; Taniguchi, Leandro U.
; Mendes, Pedro V.
; Costa, Eduardo L.V.
; Park, Marcelo
; Daltro-Oliveira, Renato
; Roepke, Roberta M.L.
; Silva Jr, João M.
; Carmona, Maria José C.
; Carvalho, Carlos Roberto Ribeiro
; Hirota, Adriana
Kanasiro, Alberto Kendy
Crescenzi, Alessandra
Fernandes, Amanda Coelho
Miethke-Morais, Anna
Bellintani, Arthur Petrillo
Canasiro, Artur Ribeiro
Carneiro, Bárbara Vieira
Zanbon, Beatriz Keiko
Batista, Bernardo Pinheiro De Senna Nogueira
Nicolao, Bianca Ruiz
Besen, Bruno Adler Maccagnan Pinheiro
Biselli, Bruno
Macedo, Bruno Rocha De
Toledo, Caio Machado Gomes De
Pompilio, Carlos Eduardo
Carvalho, Carlos Roberto Ribeiro De
Mol, Caroline Gomes
Stipanich, Cassio
Bueno, Caue Gasparotto
Garzillo, Cibele
Tanaka, Clarice
Forte, Daniel Neves
Joelsons, Daniel
Robira, Daniele
Costa, Eduardo Leite Vieira
Silva Júnior, Elson Mendes Da
Regalio, Fabiane Aliotti
Segura, Gabriela Cardoso
Marcelino, Gustavo Brasil
Louro, Giulia Sefrin
Ho, Yeh-Li
Ferreira, Isabela Argollo
Gois, Jeison de Oliveira
Silva Junior, Joao Manoel Da
Reusing Junior, Jose Otto
Ribeiro, Julia Fray
Ferreira, Juliana Carvalho
Galleti, Karine Vusberg
Silva, Katia Regina
Isensee, Larissa Padrao
Oliveira, Larissa dos Santos
Taniguchi, Leandro Utino
Letaif, Leila Suemi
Lima, Lígia Trombetta
Park, Lucas Yongsoo
Chaves Netto, Lucas
Nobrega, Luciana Cassimiro
Haddad, Luciana
Hajjar, Ludhmila
Malbouisson, Luiz Marcelo
Pandolfi, Manuela Cristina Adsuara
Park, Marcelo
Carmona, Maria José Carvalho
Andrade, Maria Castilho Prandini H De
Santos, Mariana Moreira
Bateloche, Matheus Pereira
Suiama, Mayra Akimi
Oliveira, Mayron Faria de
Sousa, Mayson Laercio
Louvaes, Michelle
Huemer, Natassja
Mendes, Pedro
Lins, Paulo Ricardo Gessolo
Santos, Pedro Gaspar Dos
Moreira, Pedro Ferreira Paiva
Guazzelli, Renata Mello
Reis, Renato Batista Dos
Oliveira, Renato Daltro De
Roepke, Roberta Muriel Longo
Pedro, Rodolpho Augusto De Moura
Kondo, Rodrigo
Rached, Samia Zahi
Fonseca, Sergio Roberto Silveira Da
Borges, Thais Sousa
Ferreira, Thalissa
Cobello Junior, Vilson
Sales, Vivian Vieira Tenório
Ferreira, Willaby Serafim Cassa













OBJECTIVES: We designed a cohort study to describe characteristics and outcomes of patients with coronavirus disease (COVID-19) admitted to the intensive care unit (ICU) in the largest public hospital in Sao Paulo, Brazil, as Latin America becomes the epicenter of the pandemic. METHODS: This is the protocol for a study being conducted at an academic hospital in Brazil with 300 adult ICU beds dedicated to COVID-19 patients. We will include adult patients admitted to the ICU with suspected or confirmed COVID-19 during the study period. The main outcome is ICU survival at 28 days. Data will be collected prospectively and retrospectively by trained investigators from the hospital’s electronic medical records, using an electronic data capture tool. We will collect data on demographics, comorbidities, severity of disease, and laboratorial test results at admission. Information on the need for advanced life support and ventilator parameters will be collected during ICU stay. Patients will be followed up for 28 days in the ICU and 60 days in the hospital. We will plot Kaplan-Meier curves to estimate ICU and hospital survival and perform survival analysis using the Cox proportional hazards model to identify the main risk factors for mortality. ClinicalTrials.gov: NCT04378582. RESULTS: We expect to include a large sample of patients with COVID-19 admitted to the ICU and to be able to provide data on admission characteristics, use of advanced life support, ICU survival at 28 days, and hospital survival at 60 days. CONCLUSIONS: This study will provide epidemiological data about critically ill patients with COVID-19 in Brazil, which could inform health policy and resource allocation in low- and middle-income countries.
https://doi.org/10.6061/clinics/2020/e2294
1957 downloads
14.
Brazilian guidelines for the pharmacological treatment of idiopathic pulmonary fibrosis. Official document of the Brazilian Thoracic Association based on the GRADE methodology
Facebook Twitter

Facebook Twitter
- Other social networks
- Google+
- StambleUpon
- CiteULike
- Mendeley
- Other networks
- Metrics
Baddini-Martinez, José
; Ferreira, Juliana
; Tanni, Suzana
; Alves, Luis Renato
; Cabral Junior, Benedito Francisco
; Carvalho, Carlos Roberto Ribeiro
; Cezare, Talita Jacon
; Costa, Claudia Henrique da
; Gazzana, Marcelo Basso
; Jezler, Sérgio
; Kairalla, Ronaldo Adib
; Kawano-Dourado, Leticia
; Lima, Mariana Silva
; Mancuzo, Eliane
; Moreira, Maria Auxiliadora Carmo
; Rodrigues, Marcelo Palmeira
; Rodrigues, Silvia Carla Sousa
; Rubin, Adalberto Sperb
; Rufino, Rogério Lopes
; Steidle, Leila John Marques
; Storrer, Karin
; Baldi, Bruno Guedes
.






















RESUMO A fibrose pulmonar idiopática (FPI) é uma forma de pneumopatia intersticial crônica fibrosante de causa desconhecida, que acomete preferencialmente homens idosos, com história atual ou pregressa de tabagismo. Mesmo sendo uma doença incomum, ela assume grande importância devido a sua gravidade e prognóstico reservado. Nas últimas décadas, diversas modalidades terapêuticas farmacológicas foram investigadas para o tratamento dessa doença, de tal modo que conceitos clássicos vêm sendo revisados. O objetivo destas diretrizes foi definir recomendações brasileiras baseadas em evidências em relação ao emprego de agentes farmacológicos no tratamento da FPI. Procurou-se fornecer orientações a questões de ordem prática, enfrentadas pelos clínicos no seu cotidiano. As perguntas PICO (acrônimo baseado em perguntas referentes aos Pacientes de interesse, Intervenção a ser estudada, Comparação da intervenção e Outcome [desfecho] de interesse) abordaram aspectos relativos ao uso de corticosteroides, N-acetilcisteína, tratamento medicamentoso do refluxo gastroesofágico, inibidores dos receptores da endotelina, inibidores da fosfodiesterase-5, pirfenidona e nintedanibe. Para a formulação das perguntas PICO, um grupo de especialistas brasileiros atuantes na área foi reunido, sendo realizada uma extensa revisão bibliográfica sobre o tema. As revisões sistemáticas com meta-análises previamente publicadas foram analisadas quanto à força das evidências compiladas e, a partir daí, foram concebidas recomendações seguindo a metodologia Grading of Recommendations Assessment, Development and Evaluation. Os autores acreditam que o presente documento represente um importante avanço a ser incorporado na abordagem de pacientes com FPI, objetivando principalmente favorecer seu manejo, e pode se tornar uma ferramenta auxiliar na definição de políticas públicas relacionadas à FPI.
ABSTRACT Idiopathic pulmonary fibrosis (IPF) is a form of chronic interstitial lung disease of unknown cause, which predominantly affects elderly men who are current or former smokers. Even though it is an uncommon disease, it is of great importance because of its severity and poor prognosis. In recent decades, several pharmacological treatment modalities have been investigated for the treatment of this disease, and the classic concepts have therefore been revised. The purpose of these guidelines was to define evidence-based recommendations regarding the use of pharmacological agents in the treatment of IPF in Brazil. We sought to provide guidance on the practical issues faced by clinicians in their daily lives. Patients of interest, Intervention to be studied, Comparison of intervention and Outcome of interest (PICO)-style questions were formulated to address aspects related to the use of corticosteroids, N-acetylcysteine, gastroesophageal reflux medications, endothelin-receptor antagonists, phosphodiesterase-5 inhibitors, pirfenidone, and nintedanib. To formulate the PICO questions, a group of Brazilian specialists working in the area was assembled and an extensive review of the literature on the subject was carried out. Previously published systematic reviews with meta-analyses were analyzed for the strength of the compiled evidence, and, on that basis, recommendations were developed by employing the Grading of Recommendations Assessment, Development and Evaluation approach. The authors believe that the present document represents an important advance to be incorporated in the approach to patients with IPF, aiming mainly to improve its management, and can become an auxiliary tool for defining public policies related to IPF.
https://doi.org/10.36416/1806-3756/e20190423
1799 downloads
15.
Quality of Briquettes Produced with Jatropha and Eucalyptus
Facebook Twitter

Facebook Twitter
- Other social networks
- Google+
- StambleUpon
- CiteULike
- Mendeley
- Other networks
- Metrics
Santos, Cynthia Patricia de Sousa
; Santos, Rosimeire Cavalcante dos
; Carneiro, Angélica de Cássia Oliveira
; Castro, Ana Flávia Neves Mendes
; Castro, Renato Vinícius Oliveira
; Costa, Sarah Esther de Lima
; Gomes, Izabelle Rodrigues Ferreira
; Mairinck, Krisnara Soares
.








Abstract Our study aims to determine the energetic quality of residues from the manufacturing of jatropha and eucalyptus, as well as to evaluate the physical properties of the briquettes made with different proportions of these biomasses. The following proportions were used for this study: 100% eucalyptus; 75% eucalyptus; 50% jatropha and 50% eucalyptus; 75% jatropha; and 100% jatropha. The apparent density of the residues, the immediate chemical product, the highest calorific value (HCV), the apparent density, the energy density, the usable calorific value (UCV), the lowest calorific value (LCV), the breaking strength of the briquettes (FR) and the hydroscopic moisture balance (HMB) were verified. Although the energetic characteristics of the jatropha residues are not superior to those of eucalyptus, this biomass adds favorable mechanical characteristics to the briquettes comprised of greater proportions of jatropha to eucalyptus, guaranteeing the energetic properties of the briquette, as well as reducing the production cost.
https://doi.org/10.1590/2179-8087.100017
362 downloads
Showing
itens per page
Page
of 2
Next
Statistics of
Send result
Sem resultados
No documents were found for your search
Glossary and search help
You can enrich your search in a very simple way. Use the search indexes combined with the connectors (AND or OR) and specify more your search.
For example, if you want to search for articles about
cases of dengue in Brasil in 2015, use:ti:dengue and publication_year:2015 and aff_country:Brasil
See below the complete list of search indexes that can be used:
Index code | Element |
---|---|
ti | article title |
au | author |
kw | article keywords |
subject | subject (title words, abstract and keywords) |
ab | abstract |
ta | journal short title (e.g. Cad. Saúde Pública) |
journal_title | journal full title (e.g. Cadernos de Saúde Pública) |
la | publication language code (e.g. pt - Portuguese, es - Spanish) |
type | document type |
pid | publication identifier |
publication_year | publication year of publication |
sponsor | sponsor |
aff_country | country code of the author's affiliation |
aff_institution | author affiliation institution |
volume | article volume |
issue | article issue |
elocation | elocation |
doi | DOI number |
issn | journal ISSN |
in | SciELO colection code (e.g. scl - Brasil, col - Colômbia) |
use_license | article usage license code |