RESUMO: A sobrevivência do homem e o desenvolvimento sustentável da sociedade dependem intimamente dos serviços dos ecossistemas florestais. Com base no método de transferência de benefícios (BTM), empregando dois tipos diferentes de métodos, este artigo calcula o valor dos serviços do ecossistema florestal (FESV) da província de Sichuan, China. Os resultados mostram que o valor dos serviços do ecossistema florestal total tem uma taxa constante de aumento na província de Sichuan de 2008 a 2018, enquanto os diferentes métodos de avaliação resultam em desvios significativos dos resultados da estimativa. Este artigo leva em conta as diferenças de biomassa e desenvolvimento socioeconômico que são ignoradas na estimativa de valor dos serviços do ecossistema florestal usando método de transferência de benefícios. Especificamente, a abordagem Carnegie-Ames-Stanford é empregada para estimar a produtividade primária líquida (NPP) de diferentes espécies florestais como fator de ajuste de biomassa. Além disso, ao usar a curva de crescimento do tipo R. Pérola S, a vontade e a capacidade das pessoas de pagar pelos serviços do ecossistema florestal são consideradas para lidar com as diferenças de desenvolvimento social. Este artigo fornece contribuições para orientar pesquisadores, gestores florestais e formuladores de políticas em pesquisas e práticas futuras para dar mais atenção aos sistemas de avaliação de escolha para valor dos serviços do ecossistema florestal e heterogeneidade regional de biomassa e desenvolvimento socioeconômico.

ABSTRACT: The survival of human and sustainable development of the society both closely rely on forest ecosystem services. Employing two different methods, this paper based on benefit transfer method calculated the forest ecosystem services value of Sichuan province, China. The results showed that the total forest ecosystem services value had a steady rate of increase in Sichuan province from 2008 to 2018, and meanwhile, the different evaluation methods resulted in significant deviation of estimation outcomes. This paper considered the differences of biomass and socioeconomic development which were ignored in prior studies. The Carnegie-Ames-Stanford approach was employed to estimate the net primary productivity of different forest species. Further, the S type R. Pearl growth curve was employed to estimate people’s willingness and ability to pay for forest ecosystem services. This paper provided implications to help forest managers and policy makers pay additional attention to the evaluation systems choosing on forest ecosystem services value and the differences of biomass and socioeconomic development by using benefit transfer method method.

ABSTRACT Purpose: Diabetes mellitus is a serious health problem worldwide, and diabetic nephropathy is the complication. The diabetic nephropathy considerably enhances the oxidative stress, glycation, lipid parameters and inflammatory reaction. Ellipticine has potent free radical scavenging and anti-inflammatory effect. Methods: In the current study, our objectives were to thoroughly examine the renal protective effects of ellipticine in a rat model of streptozotocin (STZ)-induced diabetic nephropathy (DN) and to elucidate the underlying mechanisms involved. For the induction of diabetic nephropathy, streptozotocin (50 mg/kg) was used, and rats were separated into groups and given varying doses of ellipticine (2.5, 5 and 7.5 mg/kg). The body weight, and renal weight were estimated. The inflammatory cytokines, renal biomarkers, inflammatory antioxidant, and urine parameters were estimated. Results: Result showed that ellipticine considerably enhanced the body weight and reduced the renal tissue weight. Ellipticine treatment significantly (P < 0.001) repressed the level of blood urea nitrogen, serum creatinine, uric acid, blood glucose and altered the lipid parameters. Ellipticine significantly (P < 0.001) repressed the level of malonaldehyde and boosted the glutathione, catalase, superoxide dismutase, and glutathione peroxidase. Ellipticine treatment significantly (P < 0.001) reduced the inflammatory cytokines and inflammatory mediators. Conclusions: Ellipticine could be a renal protective drug via attenuating the inflammatory reaction, fibrosis and oxidative stress in streptozotocin induced rats.

This study aimed to explore changes in nanoscale elastic modulus of the synovium using atomic force microscopy (AFM) in addition to investigate changes in synovial histomorphology and secretory function in osteoarthritis (OA) in a rat anterior cruciate ligament transection (ACLT) model. Sprague-Dawley rats were randomly assigned to sham control and ACLT OA groups. All right knee joints were harvested at 4, 8, or 12 weeks (W) after surgery for histological assessment of cartilage damage and synovitis in both the anterior and posterior capsules. AFM imaging and nanoscale biomechanical testing were conducted to measure the elastic modulus of the synovial collagen fibrils. Immunohistochemistry was used to visualize the expression of interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α), and matrix metalloproteinase-3 (MMP-3) in the synovium. The OA groups exhibited progressive development of disease in the cartilage and synovium. Histopathological scores of the synovium in the OA groups increased gradually. Significant differences were observed between all OA groups except for the posterior 4W group. The synovial fibril arrangement in all OA groups was significantly disordered. The synovial fibrils in all ACLT OA groups at each time point were stiffer than those in the sham controls. OA rats displayed a significantly higher expression of IL-1β and MMP3 in the anterior capsule. In summary, synovial stiffening was closely associated with joint degeneration and might be a factor contributing to synovitis and increased production of proinflammatory mediators. Our data provided insights into the role of synovitis, particularly stiffening of the synovium, in OA pathogenesis.

RESUMO: Utilizamos os dados da Pesquisa de Dinâmica da Força de Trabalho da China de 2014 para examinar os efeitos dos capitais de subsistência, que incluem capitais natural, material, humano, financeiro e social sobre a renda total da família, renda per capita, renda agrícola, renda salarial, renda operacional e desigualdade de renda da propriedade entre as famílias rurais da China. Os resultados mostraram que diferentes tipos de capitais de subsistência têm efeitos diferentes sobre os diferentes tipos de renda das famílias rurais. Especificamente, (1) embora a área de terra cultivada reduza a desigualdade de renda agrícola, aumenta a desigualdade de renda per capita. (2) A área florestal aumenta a desigualdade de renda per capita e a desigualdade total de renda familiar. (3) A variável trator reduz a desigualdade na renda agrícola e na renda familiar total. (4) Embora reduza a desigualdade de renda da propriedade, a variável educação aumenta a desigualdade de renda salarial, a desigualdade de renda per capita e a desigualdade total de renda familiar. (5) A variável contábil reduz a desigualdade de renda da propriedade. (6) A variável empréstimo aumenta a desigualdade na renda agrícola. (7) A variável partidária reduz a desigualdade de renda agrícola. (8) Embora a variável internet aumente a desigualdade de renda agrícola e a desigualdade de renda da propriedade, reduz a desigualdade de renda salarial, a desigualdade de renda operacional, a renda per capita e a desigualdade total de renda familiar.

ABSTRACT: We used the data of the China Labor-force Dynamics Survey 2014 to examine the effects of livelihood capitals which include natural, material, human, financial, and social capitals on total household income, per capita income, agricultural income, wage income, operational income, and property income inequality among rural households in China. Results showed that different kinds of livelihood capitals have different effects on different types of rural households’ income. Specifically; (1) although, the area of cultivated land reduces agricultural income inequality, it increases per capita income inequality. (2) Forest land area enlarges per capita income inequality and total household income inequality. (3) Tractor variable reduces inequality in agricultural income and total household income. (4) While reducing the property income inequality, education variable enlarges the wage income inequality, the per capita income inequality and the total household income inequality. (5) Book variable reduces property income inequality. (6) Loan variable increases inequality in agricultural incomes. (7) Party variable reduces the agricultural income inequality. (8) Although, the internet variable increases agricultural income inequality, and property income inequality, it reduces wage income inequality, operational income inequality, per capita income, and total household income inequality.

The microstructures of high-Si Al alloy cylindrical simples produced by rheological squeeze-casting with bottom-up filling were investigated. The effect of process parameters on the distribution of hard phases (primary Si and Fe-rich phase) was evaluated, and flow characteristics of semi-solid slurry of high-Si Al alloy were investigated. Differences in volume fractions (VFs) of hard phases between the middle and upper layers of cylindrical samples decreased as the squeezing speed increased. Moreover, the flow state of the semi-solid alloy slurry transitioned from laminar to turbulent flow as the squeezing speed was increased. Movement of gases throughout the semi-solid alloy slurry filling process was analysed under different process parameters. The results provide insights for improving rheological casting of high-Si Al alloy and other Al matrix composites.

RESUMO: As fazendas tibetanas e lares de pastores na província de Gansu, na China, são atingidas pela pobreza. Resolver o problema da pobreza neste ou em outros aglomerados em toda a China tem importância especial para a estabilidade política do país, a unidade étnica, o bem-estar social e a segurança ecológica. Esta pesquisa calcula a situação multidimensional da pobreza das famílias de fazendeiros e pastores tibetanos da Província de Gansu, usando o método Alkire-Foster. Doze indicadores estão incluídos no sistema multidimensional de indicadores de pobreza. Os resultados mostram que: 1) na medida de indicador único, os membros adultos da família receberam o grau de instrução até, pelo menos, a 9ª série (x3); o tipo de banheiro (x7) e a disponibilidade de mão-de-obra (x2) apresentam maior incidência de privação; 2) muitas FHH nas áreas tibetanas da Província de Gansu enfrentam pobreza multidimensional, mas a proporção de pobreza extrema é muito pequena e, 3) do ponto de vista da taxa de contribuição, os membros adultos da família receberam pelo menos a 9ª série (x3), disponibilidade (x2), a análise de auto-avaliação (x1), o tipo de banheiro domiciliar (x7) e a taxa de desistência de crianças em idade escolar (x4) ocuparam as cinco primeiras posições obtidas do método de peso igual a dimensões (DEW).

ABSTRACT: Ethnic Tibetan farm and herder households (FHH) in Gansu Province, China are stricken with poverty. Solving the poverty problem in this or other poverty pockets across China has special importance for the country’s political stability, ethnic unity, social well-being, and ecological security. This paper calculates the multidimensional poverty situation of ethnic Tibetan farm and herder households of Gansu Province, China by using the Alkire-Foster method. Twelve indicators are included in the multidimensional poverty indicator system. Results showed that 1) in the single indicator measure, the adult family members received at least 9th grade education (x3), the home toilet type (x7), and the labor availability (x2) showed a higher incidence of deprivation, 2) many FHH in the Tibetan areas of the Gansu Province are facing multidimensional poverty but the proportion of extreme poverty is very small, and 3) from the perspective of contribution rate, the adult family members received at least 9th grade education (x3), labor availability (x2), self-health assessment (x1), home toilet type (x7), and school-age children dropout rate (x4) occupied the top five positions as obtained from the equal weight to dimensions (DEW) method.

Oxidative stress underlies many forms of vascular disease as well as tissue injury following ischemia and reperfusion. The major source of oxidative stress in the artery wall is an NADPH oxidase. This enzyme complex as expressed in vascular cells differs from that in phagocytic leucocytes both in biochemical structure and functions. The crucial flavin-containing catalytic subunits, Nox1 and Nox4, are not found in leucocytes, but are highly expressed in vascular cells and upregulated with vascular remodeling, such as that found in hypertension and atherosclerosis. The difference in catalytic subunits offers the opportunity to develop "vascular specific" NADPH oxidase inhibitors that do not compromise the essential physiological signaling and phagocytic functions carried out by reactive oxygen and nitrogen species. Nitric oxide and targeted inhibitors of NADPH oxidase that block the source of oxidative stress in the vasculature are more likely to prevent the deterioration of vascular function that leads to stroke and heart attack, than are conventional antioxidants. The roles of Nox isoforms in other inflammatory conditions are yet to be explored.