SUMMARY OBJECTIVE: Ureteral stents usually cause pain and lower urinary tract discomfort. This study aimed to compare the effect of mirabegron with oxybutynin in relieving ureteral stent-related symptoms over time. METHODS: A prospective, longitudinal, randomized, single-blinded study was conducted. Patients who had a ureteral stent inserted after urolithiasis treatment were classified into two groups and received either oxybutynin 5 mg/day (Group O) or mirabegron 50 mg/day (Group M). The Ureteral Stent Symptoms Questionnaire (USSQ) was applied on the 3rd, 6th, and 15th postoperative days. Group domain scores were compared, and a mixed linear model was used to better assess score differences. RESULTS: Ureteral Stent Symptoms Questionnaire scores were similar in both groups during all three postoperative days (p>0.05). A longitudinal analysis showed that global quality of life and general health improved over time, independently of the use of any of the medications (p<0.05), while urinary symptoms and body pain scores were lower over time in participants receiving oxybutynin. CONCLUSION: Both mirabegron and oxybutynin are equivalent in relieving ureteral stent symptoms. Moreover, some stent symptoms seem to decrease over time despite the use of medication.

ABSTRACT Objectives: This study aims to verify the new-onset diabetes after kidney transplant (NODAT) incidence in recipients within 1 year after kidney transplantation from a single center in Southern Brazil and to assess the associated conditions. Subjects and methods: A retrospective study of 258 post-renal transplant patients was performed. Demographic (gender, age, ethnic background) and clinical (origin of graft, associated infections, body mass index (BMI) at transplant time and 6 and 12 months after, causes of renal failure, and comorbidities) data were analyzed. All patients were on tacrolimus, mycophenolate mofetil, and prednisone treatment. Patients with and without NODAT were compared. Results: A NODAT incidence of 31.2% was noted 1 year post transplantation. In the univariate analysis, patients with NODAT were older (p = 0.001), mostly had African–American ethnic background (p = 0.02), and had renal failure secondary to high blood pressure (HBP) (p = 0.001). The group of patients with NODAT also had more incidence of post-transplant HBP (p = 0.01), heart failure (p = 0.02), and dyslipidemia (p = 0.001). Logistic regression showed that African–American ethnic background, post-transplant HBP, and dyslipidemia were independently associated with NODAT. Conclusion: This study shows a NODAT incidence that is greater in patients with African–American ethnic background and that is associated with HBP and dyslipidemia.

ABSTRACT Objective The objective of this study was to correlate the values of abdominal circumference (AC) and body mass index (BMI) with the levels of total testosterone (TT), free testosterone (FT) and sexual hormone binding globulin (SHBG). We aimed to analyze the association between the anthropometric values and variations in the hormonal levels. Subjects and methods A transversal prospective study was conducted. A total of 159 patients were included in the study. Results BMI was inversely correlated with TT and SHBG (p = 0.02 and p = 0.006, respectively). AC was also inversely correlated withTT and SHBG (p = 0.006 and p < 0.0001, respectively). However, BMI did not correlate signicantly with these hormonal levels after adjusting for age. Conclusion This finding led to the conclusion that AC had a stronger inverse correlation than BMI with TT and SHBG. Our data suggested that AC alone can be used as an anthropometric parameter to help simplify the identification of men with low serum TT levels.

Este trabalho teve como objetivo avaliar o efeito de métodos de controle de espécies indesejáveis e de intensidades de pastejo sobre o desempenho animal em pastagem nativa da Serra do Sudeste do Rio Grande do Sul. Foram utilizados os métodos de controle: roçada de primavera (RP), roçada de outono (RO), controle químico (Q) e um tratamento testemunha (T), todos submetidos a dois níveis de oferta de forragem, médio (8%) e alto (14%), expressos em kg de matéria seca diariamente ofertada para cada 100kg de peso vivo animal. O delineamento experimental empregado foi o de blocos completamente casualizados, num arranjo fatorial com duas repetições. A análise estatística não demonstrou interação entre os fatores estudados, bem como existência de diferença entre os métodos de controle de espécies indesejáveis para as variáveis de produção primária e secundária (P>0,1). Não houve diferença de ganho médio diário entre os níveis de oferta de forragem estudados (P>0,1). Animais submetidos à alta oferta de forragem apresentaram menor perda de peso por unidade de área (P<0,1).

This work aimed to evaluate the effect of different undesirable plants controlling methods and grazing intensities on animal production in native pastures. The treatments were no control (T), spring clipping (P), autumn clipping (O) and chemical control (Q), under two levels of forage allowance, medium (8%) and high (14%), expressed in kg of dry matter offered daily per each 100kg of liveweight. The experimental design was a completely randomized block arranged in a factorial with two repetitions. Statistical analysis showed no interaction among treatments nor differences among control methods for variables concerning primary and secondary production (P>0.1). Animal performance in both forage allowances was not different (P>0.1). High forage allowances increased animal performance per unit area (P<0.1).

O objetivo deste trabalho foi avaliar as características de carcaça, de cordeiros mantidos em pastagem de azevém anual (Lolium multiflorum Lam.) manejada em diferentes alturas (5, 10, 15 e 20 cm), sob lotação contínua com carga variável, no período de agosto a novembro de 1999. Utilizou-se um delineamento em blocos ao acaso, com três repetições, e as variáveis estudadas foram submetidas à análise de regressão. Os pesos de abate, carcaça quente, filé mignon, paleta e costela diferiram entre os tratamentos e foram inferiores no tratamento relativo à altura de manejo de 5 cm, quando comparados aos tratamentos de 10, 15 e 20 cm, que não diferiram entre si. Não houve diferença entre tratamentos para os pesos de pernil e de carré. O rendimento de carcaça variou entre 42,8±0,29 e 44,1±0,32%. Todas as variáveis apresentaram relação quadrática com os tratamentos. O ganho médio diário influenciou diretamente o peso de abate que, por sua vez, correlacionou fortemente com o rendimento e o peso da carcaça. Os resultados mostram que os melhores rendimentos dos cortes comerciais de cordeiros são obtidos quando a pastagem de azevém é manejada no intervalo entre 12 e 14 cm de altura.

The objective of this work was to evaluate the carcass characteristics of lambs maintained on ryegrass (Lolium multiflorum Lam.) pastures managed with different heights (5, 10, 15 and 20 cm), under continuous variable stocking, from August to November 1999. A randomized block design with three replicates was used. The slaughter weight, hot carcass, fillet, palette and rib weights were different among treatments, and those related to the height 5 cm were lower than the ones of 10, 15 and 20 cm, which were not different among them. There were no differences for hind leg and rib loin. Carcass yield ranged from 42.8±0.29 and 44.1±0.32%. All variables showed a quadratic relationship to treatments. The daily liveweight gain determined directly the liveweight at slaughter, the latter being strongly correlated to carcass yield and weight. Better yield of lamb carcass cuts were obtained when ryegrass was managed between 12 and 14 cm height.

Variáveis morfogênicas e estruturais foram quantificadas a partir da técnica de "perfilhos marcados" no período de agosto a outubro de 1999 numa pastagem de azevém anual, mantida em quatro diferentes alturas (5, 10, 15 e 20 cm) através de lotação contínua em carga variável com ovinos. O delineamento experimental foi o de blocos completos casualizados com três repetições. Utilizaram-se 50 perfilhos marcados por unidade experimental, distribuídos ao longo de transectas. As observações foram efetuadas em dois períodos: no primeiro, da entrada dos animais até a obtenção das alturas pretendidas, não se observaram diferenças entre os tratamentos. No segundo (fase de estabilização das alturas pretendidas), a taxa de elongação foliar, o comprimento da lâmina verde total por perfilho e o tamanho das folhas apresentaram resposta positiva frente a maiores alturas de manejo, enquanto o tempo de elongação da lâmina foliar diminui com a altura. As variáveis taxa de surgimento de folhas, tempo de vida das folhas, densidade populacional de perfilhos e número de folhas vivas por perfilho não foram afetadas pelos tratamentos.

Morphogenetic and structural variables were obtained from measurements performed on marked tillers and were quantified during August to October 1999 in a ryegrass pasture grazed by sheep under continuous stocking and variable stocking rate in order to maintain the sward at four different heights (5, 10, 15 and 20 cm). The experimental design was a randomized complete block with three replicates. Fifty marked tillers per experimental unit were assessed and distributed along transects lines. Sward measurements were performed in two periods: the first one, from the start of grazing until the point where the intended grazing heights were established, with no differences among treatments. In the second (after achieving the intended grazing heights), leaf elongation rate, total green leaf lamina length per tiller and leaf size showed a positive response to increasing sward heights, while the time to leaf lamina elongation decreased. The variables leaf appearance rate and leaf life span, tiller population density and number of live leaves per tiller were not affected by treatments.