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Abstract We examined the relationships among gender, planning, and academic expectations through the testing of two alternative models with latent variables tested with LISREL 8.80: one model considered planning as a mediator of the relationship between gender and academic expectations, and the other model considered academic expectations as mediators of the relationship between gender and planning. Participants were 662 first-year higher-education students from two academic years, predominantly female (60%) and mainly with majors in the juridical-social field (66.2%). The Inventario sobre Estrategias Metacognitivas (IEM; Inventory of Metacognitive Strategies) and the Academic Perceptions Questionnaire (APQ) were applied at the beginning of the first semester to assess planning and academic expectations, respectively. Multigroup confirmatory factor analysis was used to test the IEM’s structure after examining its psychometric properties with the sample from the first academic year (N = 338). The test of the alternative mediation models with the full sample indicates that the best model was that with planning as a mediator. In this model, gender directly predicted only two APQ academic expectations, but with the mediation of planning, gender predicted all seven academic expectations. Women showed higher levels of academic expectations and planning than did men. The results are discussed at both the theoretical and practical levels.

https://doi.org/10.1186/s41155-020-00142-z

BLANCO, Fernando A.; PECHENY, Mario; & PIERCE, Joseph M (eds.) 2018. Políticas del amor: derechos sexuales y escrituras disidentes en el cono sur. 1ª ed. Santiago de Chile: Cuarto Propio. 356 p.
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Pascual, Héctor Iglesias

Sexualidad, Salud y Sociedad (Rio de Janeiro)

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apr 2019, N. 31 Pages 146 - 150

Abstract: Es | Text: Es | PDF: Es

https://doi.org/10.1590/1984-6487.sess.2019.31.09.a

Efecto de los antimaláricos sobre los diferentes dominios del índice de daño SLICC en pacientes de la cohorte GLADEL
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Pons-Estel, Guillermo J.

; Quintana, Rosana

; Wojdyla, Daniel

; Alarcón, Graciela S.

; Serrano, Rosa María

; Ugarte-Gil, Manuel

; Pimentel-Quiroz, Víctor

; Soriano, Enrique R.

; Catoggio, Luis J.

; Scolnik, Marina

; Sacnun, Mónica

; Saurit, Verónica

; Caeiro, Francisco

; Alvarellos, Alejandro

; Sarano, Judith

; García, Mercedes

; Onetti, Laura

; Drenkard, Cristina

; Berbotto, Guillermo

; Scherbarth, Hugo R.

; Sato, Emilia

; Bonfa, Eloisa

; Ferreira Borba, Eduardo

; Costallat, Lilian

; Xavier, Ricardo

; Tavares Brenol, Joao C.

; Da Silva, Nilzio A.

; Cavalcanti, Fernando

; Massardo, Loreto

; Jacobelli, Sergio

; Neira, Oscar

; Molina, José F

; Vásquez, Gloria

; Gómez-Puerta, José A.

; Alonso Gonzalez, Luis

; Iglesias Gamarra, Antonio

; Guibert-Toledano, Marlene

; Reyes, Gil A.

; Cardiel, Mario H.

; Pascual-Ramos, Virginia

; García de la Torre, Ignacio

; Barile, Leonor

; Silveira, Luis H.

; Amigo, Mary-Carmen

; Sauza del Pozo, María Josefina

; Acevedo-Vásquez, Eduardo M.

; Alfaro-Lozano, José

; Segami, María Inés

; Chacón-Díaz, Rosa

; Abadi, Isaac

; Esteva Spinetti, María H

; Pons-Estel, Bernardo A.

Revista argentina de reumatología

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sep 2018, Volume 29 N. 3 Pages 6 - 10

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

Objective: To assess the effects of antimalarials (AM) over the items of the SLICC Damage Index (SDI). Methods: Patients with recent (≤2 years) diagnosis of systemic lupus erythematosus (SLE) from the GLADEL cohort were studied. End-point: increase in items SDI since cohort entry. Independent variables (socio-demographic, clinical, laboratory and treatment) were included. The effect of AM as a time dependent variable on most frequent SDI items (adjusting for potential confounders) was examined with a multivariable Cox regression model. Results: Of the 1466 patients included in this analysis, 1049 (72%) received AM with a median exposure time of 30 months (Q1-Q3: 11-57). Damage occurred in 665 (45%) patients during a median follow-up time of 24 months (Q1-Q3: 8-55). There were 301 integument, 208 renal, 149 neuropsychiatric, 98 musculoskeletal, 88 cardiovascular and 230 others less frequently represented damages. After adjusting for potential confounders at any time during follow-up, a lower risk of renal damage (HR 0.652; 95% CI: 0.472-0.901) and borderline for neuropsychiatric damage (HR 0.701, 95% CI: 0.481-1.024) was found. Conclusion: In the GLADEL cohort, after adjustment for possible confounding factors, AM were independently associated with a reduced risk of renal damage accrual.

Objetivos: Estimar el efecto de los antimaláricos (AM) sobre los diferentes dominios del índice de daño SLICC (SDI). Métodos: Se estudiaron pacientes con diagnóstico clínico reciente (≤2 años) de lupus eritematoso sistémico (LES) de la cohorte GLADEL. Variable de estudio: aumento en los dominios del SDI desde el ingreso a la cohorte. Variables independientes: características sociodemográficas, clínicas, laboratorio y tratamientos. El efecto de los AM, como variable dependiente del tiempo, sobre los dominios más frecuentes del SDI (ajustado por factores de confusión) fue examinado con un modelo de regresión de Cox multivariado. Resultados: De 1466 pacientes estudiados, 1049 (72%) recibieron AM con un tiempo medio de exposición de 30 meses (Q1-Q3: 11-57) y 665 pacientes (45%) presentaron daño durante un seguimiento medio de 24 meses (Q1-Q3: 8-55); 301 eventos fueron cutáneos, 208 renales, 149 neuropsiquiátricos, 98 musculoesqueléticos, 88 cardiovasculares y 230 otros. Después de ajustar por factores de confusión, el uso de AM se asoció a un menor riesgo de daño renal (HR 0,652; IC 95%: 0,472-0,901) y en el límite de la significancia estadística (HR 0,701, IC 95%: 0,481-1,024) para el dominio neuropsiquiátrico. Conclusión: En GLADEL, el uso de AM se asoció independientemente a un menor riesgo de daño acumulado renal.

Comparative study of systemic early postoperative inflammatory response among elderly and non-elderly patients undergoing laparoscopic cholecystectomy
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FIALHO, LUCIANA

; CUNHA-E-SILVA, JOSÉ ANTONIO

; SANTA-MARIA, ANTONIO FELIPE

; MADUREIRA, FERNANDO ATHAYDE

; IGLESIAS, ANTONIO CARLOS

Revista do Colégio Brasileiro de Cirurgiões

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2018, Volume 45 N. 1 elocation e1586

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

ABSTRACT Objective: to evaluate and compare the early postoperative period systemic inflammatory response between elderly and non-elderly patients submitted to laparoscopic cholecystectomy, mainly performing a quantitative analysis of interleukin-6 (IL-6), a marker of inflammatory activity systemic. Methods: we compared a series of cases over a period of six months at the Gaffrée and Guinle University Hospital of the Federal University of the State of Rio de Janeiro, involving 60 patients submitted to elective laparoscopic cholecystectomy. We used non-probabilistic sampling for convenience, selecting, from the inclusion criteria, the first 30 patients aged 18-60 years, who comprised group I, and 30 patients with age equal to or greater than 60 years, who formed group II. Results: the 60 patients involved were followed for at least 30 days after surgery and there were no complications. There was no conversion to open surgery. The values of the medians found in the IL-6 dosages for the preoperative period, three hours after the procedure and 24 hours after surgery were, respectively, 3.1 vs. 4.7 pg/ml, 7.3 vs. 14.1 pg/ml and 4.4 vs 13.3 pg/ml. Conclusion: Elderly patients were more responsive to surgical trauma and had elevated IL-6 levels for a longer period than the non-elderly group.

RESUMO Objetivo: avaliar e comparar a resposta inflamatória sistêmica no pós-operatório precoce de pacientes idosos e não idosos submetidos à colecistectomia vídeo-laparoscópica, realizando, sobretudo, análise quantitativa de interleucina-6 (IL-6), que representa um marcador de atividade inflamatória sistêmica. Métodos: estudo de série de casos, comparativo, realizado num período de seis meses, no Hospital Universitário Gaffrée e Guinle da Universidade Federal do Estado do Rio de Janeiro, envolvendo 60 pacientes com indicação de colecistectomia laparoscópica eletiva. Amostragem não probabilística por conveniência foi utilizada, selecionando, a partir dos critérios de inclusão, os primeiros 30 pacientes com idades entre 18 e 60 anos, que compuseram o grupo I e os 30 pacientes com idade igual ou maior que 60 anos, que formaram o grupo II. Resultados: os 60 pacientes envolvidos foram acompanhados por no mínimo 30 dias após o término da cirurgia e não houve complicações. Não houve conversão para cirurgia aberta. Os valores das medianas encontrados nas dosagens da IL-6, nos grupos I e II, para cada momento analisado (pré-operatório, três horas após e 24 horas após) foram, respectivamente: 3,1 x 4,7 pg/ml no pré-operatório, 7,3 x 14,1 pg/ml após três horas do procedimento e 4,4 x 13,3 pg/ml na 24a hora do pós-operatório. Conclusão: pacientes idosos responderam de forma mais exacerbada ao trauma cirúrgico e apresentaram elevação dos níveis de IL-6 por um período maior do que o grupo de não idosos.

https://doi.org/10.1590/0100-6991e-20181586

Defectos óseos diafisarios postraumáticos en la extremidad superior de niños
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Gentile, Luciano

; Iglesias, Santiago L

; Lobos Centeno, Esteban

; Vanoli, Fernando

; Allende Nores, Christian A

Revista de la Asociación Argentina de Ortopedia y Traumatología

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dec 2017, Volume 82 N. 4 Pages 277 - 293

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

Introduction: The aim of this study was to evaluate the results achieved in children with chronic segmental bone defects at the humerus or forearm. Methods: Nine children, treated between 2005 and 2015, presenting long bone upper extremity fractures that got infected resulting in segmentary bone defects were retrospectively evaluated; all lesions had 6 or more months from trauma. Seven patients were male and two female, with an average age of 9.9 years. Four defects were located at the humerus, three at the ulna, and two at the radius. All patients had had previous surgical interventions (average 3.7), originating bony defects that averaged 4.5 cm. Time from initial trauma to definitive surgery averaged 21.8 months. Results: Follow-up averaged 2.2 years. Union was achieved in all patients. A cement spacer was used in one case, in another case a free fibular bone graft was used. Two patients with humeral defects had significant shortening. All patients returned to their recreational and sports activities without limitations. Conclusions: The combination of different types of bone autograft, various plaques placed bypassing the lesion and the induced membrane technique allowed us to obtain consolidation and return to normal activity in the nine children with segmental bone defects in humerus, ulna or radius.

Introducción: El objetivo de este estudio fue evaluar si la combinación de osteosíntesis asociadas a autoinjerto óseo representa un método terapéutico eficaz y confiable en niños con defectos óseos segmentarios diafisarios crónicos en el húmero o los huesos del antebrazo. Materiales y Métodos: Se evaluó retrospectivamente a nueve niños, tratados entre 2005 y 2015, con fracturas en huesos largos de la extremidad superior que se infectaron y resultaron en defectos óseos segmentarios; todas con ≥6 meses de evolución desde el trauma inicial. Se incluyó a 7 niños y 2 niñas, con una edad promedio de 9.9 años. Cuatro defectos óseos se localizaban en el húmero; tres, en el cúbito y dos, en el radio. Todos habían sido sometidos a intervenciones quirúrgicas (promedio 3,7) que originaron defectos óseos de 4,5 cm en promedio. El tiempo entre el trauma inicial y la cirugía definitiva promedió los 21.8 meses. Resultados: El seguimiento promedio fue de 2.2 años. Se obtuvo la consolidación en todos los casos. En un paciente, se utilizó espaciador de cemento y, en otro, injerto libre de peroné. Dos pacientes con lesión en el húmero presentaron un acortamiento significativo. Todos los niños retomaron sus actividades deportivas y recreativas sin limitaciones. Conclusiones: Mediante la combinación de diferentes tipos de autoinjerto óseo, diversas placas colocadas puenteando la lesión y la técnica de la membrana inducida, se logró la consolidación y los nueve niños con defectos óseos diafisarios segmentarios en húmero, cúbito o radio retornaron a sus actividades normales.

Exposición a la radiación de los cirujanos en la fijación interna de fracturas de radio distal
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Vanoli, Fernando

; Gentile, Luciano

; Iglesias, Santiago L

; Lobos Centeno, Esteban

; Diaz, María Pilar

; Allende Nores, Christian A

Revista de la Asociación Argentina de Ortopedia y Traumatología

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dec 2017, Volume 82 N. 4 Pages 271 - 277

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

Introduction: The objective of this study is to provide reference values of radiation doses absorbed by surgeons during open reduction and internal fixation of distal radius fractures. Methods: We prospectively evaluated radiation exposure during surgery for distal radius fracture between May and December 2015. Exposure was evaluated in two surgeons using dosimeters in thorax, neck, and wrist. A relative radiation index for each surgery was calculated to identify the differences among sites and to establish reference values for radiation monitoring. Results: Results of surgery performed in 50 patients were evaluated. Surgical procedure averaged 40 minutes (SD 2.06), and there were no statistically significant differences between both surgeons (p=0.043). C-arm exposure time averaged 75 seconds. There were significant differences between surgeons (p=0.007) or among sites (p<0.05). Radiation in the thorax was smaller (protected with a lead vest, 0.04 mSv) than in the other two sites (not protected with lead): wrist 0.017 mSv and thyroid 0.18 mSv. Conclusions: During open reduction and internal fixation of distal radius fractures, surgeons are exposed to direct radiation during fluoroscopy, which varies according to the exposure site and it is not uniform among surgeons. The amount of radiation received by surgeons, when only distal radius fractures are considered, cannot be associated with increased risk of cancer or malignancy development.

Introducción: El objetivo de este estudio es proveer valores de referencia de dosis de radiación absorbida por el cirujano en la reducción abierta y fijación interna con placa volar de fracturas inestables de radio distal. Materiales y Métodos: Entre mayo y diciembre de 2015, se evaluó prospectivamente la exposición a la radiación de dos cirujanos, usando dosímetros en tórax, cuello y muñeca en las cirugías de fracturas inestables de radio distal. Se construyó un índice relativo para cada cirugía a fin de identificar las diferencias entre los sitios y establecer valores de referencia para el monitoreo de la exposición. Resultados: Se evaluaron los resultados en las cirugías de 50 pacientes. El procedimiento quirúrgico promedió 40 minutos (DE 2.06); se hallaron diferencias estadísticamente significativas entre los dos cirujanos (p = 0,043). El tiempo promedio de exposición del arco en C fue de 75 segundos y difirió significativamente entre los cirujanos (p = 0,007) y entre los sitios (p <0,05). Hubo menos radiación en el tórax (protegido con chaleco de plomo, 0,04 mSv) que en los otros dos sitios (no protegidos): muñeca 0,017 mSv y tiroides 0,18 mSv. Conclusiones: En la reducción abierta y fijación interna de fracturas de radio distal, los cirujanos están expuestos a la radiación directa durante la fluoroscopia, la cual varía conforme el sitio de exposición y no es homogénea entre los profesionales. La cantidad de radiación recibida por los cirujanos, cuando se consideran aisladamente las fracturas de radio distal, no puede asociarse a un mayor riesgo de cáncer o desarrollo de malignidad.

LATE EVALUATION OF DYSPHAGIA AFTER HELLER ESOPHAGEAL MYOTOMY WITH DOR FUNDOPLICATION FOR ACHALASIA
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CÂMARA, Eduardo Rodrigues Zarco

; MADUREIRA, Fernando Athayde Veloso

; MADUREIRA, Delta

; SALOMÃO, Renato Manganelli

; IGLESIAS, Antonio Carlos Ribeiro Garrido

ABCD. Arquivos Brasileiros de Cirurgia Digestiva (São Paulo)

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sep 2017, Volume 30 N. 3 Pages 182 - 186

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

ABSTRACT Background: All available treatments for achalasia are palliative and aimed to eliminate the flow resistance caused by a hypertensive lower esophageal sphincter. Aim: To analyze the positive and negative prognostic factors in the improvement of dysphagia and to evaluate quality of life in patients undergoing surgery to treat esophageal achalasia by comparing findings before, immediately after, and in long follow-up. Methods: A total of 84 patients who underwent surgery for achalasia between 2001 and 2014 were retrospectively studied. The evaluation protocol with dysphagia scores compared preoperative, immediate (up to three months) postoperative and late (over one year) postoperative scores to estimate quality of life. Results: The surgical procedure was Heller-Dor in 100% of cases, with 84 cases performed laparoscopically. The percent reduction in pre- and immediate postoperative lower esophageal sphincter pressurewas 60.35% in the success group and 32.49% in the failure group. Regarding the late postoperative period, the mean percent decrease was 60.15% in the success group and 31.4% in the failure group. The mean overall drop in dysphagia score between the pre- and immediate postoperative periods was 7.33 points, which represents a decrease of 81.17%. Conclusions: Reduction greater than 60% percent in lower esophageal sphincter pressurebetween the pre- and postoperative periods suggests that this metric is a predictor of good prognosis for surgical response. Surgical treatment was able to have a good affect in quality of life and drastically changed dysphagia over time.

RESUMO Racional: Todos os tratamentos disponíveis para a acalásia são paliativos e visam eliminar a resistência ao fluxo causada por esfíncter esofágico inferior hipertenso. Objetivos: Avaliar os fatores prognósticos positivos e negativos na melhora da disfagia e avaliar a qualidade de vida em pacientes submetidos à cirurgia para tratar a acalásia esofágica, comparando os achados antes, imediatamente após e tardiamente à operação. Métodos : Foram estudados retrospectivamente 84 pacientes submetidos à operação de acalásia entre 2001 e 2014. O protocolo de avaliação com escores de disfagia comparou os escores pré-operatórios, do pós-operatório imediato (até três meses) e pontuação pós-operatória tardia (acima de um ano) para estimar a qualidade de vida. Resultados: O procedimento cirúrgico foi Heller-Dor em 100% dos casos, com 84 casos laparoscópicos. A redução percentual na pressão do esfíncter esofágico inferior pré e pós-operatório imediato foi de 60,35% no grupo de sucesso e de 32,49% no grupo de falha. Em relação ao período pós-operatório tardio, a redução percentual média foi de 60,15% no grupo de sucesso e 31,4% no grupo de falência. A queda média do escore de disfagia entre os períodos pré e pós-operatório imediato foi de 7,33 pontos, o que representa diminuição de 81,17%. Conclusões: A redução de mais de 60% da pressão do esfíncter esofágico inferior entre os períodos pré e pós-operatório sugere que ela é preditora de bom prognóstico cirúrgico. O tratamento cirúrgico foi capaz de contribuir na qualidade de vida e alterar em muito a disfagia em longo prazo.

https://doi.org/10.1590/0102-6720201700030005

A new SLC12A3 founder mutation (p.Val647Met) in Gitelman's syndrome patients of Roma ancestry
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Gil-Peña, Helena

; Coto, Eliecer

; Santos, Fernando

; Espino, Mar

; Cea Crespo, Jose Mª

; Chantzopoulos, Giannis

; Komianou, Filadelfia

; Gómez, Juan

; Alonso, Belén

; Iglesias, Sara

; Treard, Cyrielle

; Vargas-Poussou, Rosa

Nefrología (Madrid)

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aug 2017, Volume 37 N. 4 Pages 423 - 428

Abstract: Es En | Text: Es En | PDF: Es | PDF: En

Resumen Antecedentes: El síndrome de Gitelman (SG) es un trastorno autosómico recesivo causado por las mutaciones en el gen SLC12A3.El SG se caracteriza por una alcalosis metabólica hipopotasémica, hipomagnesemia e hipocalciuria. La mayoría de los pacientes de etnia gitana notificados son homocigotos para la mutación con desplazamiento del marco de lectura del intrón 9 de SLC12A3 (c.1180 + 1G>T). Algunas formas del síndrome de Bartter proceden de las mutaciones del gen CLNCKB y se solapan clínicamente con el SG. Objetivos: Determinar las características de una segunda mutación en SLC12A3 en pacientes de etnia gitana con resultados negativos en la variante intrón 9. Métodos: Se analizaron los genes SLC12A3 y CLNCKB mediante secuenciación de nueva generación en 2 pacientes -uno español y otro griego- de etnia gitana con resultados negativos en la mutación de empalme del intrón 9. Se llevó a cabo una secuenciación de Sanger para confirmar las supuestas mutaciones en los pacientes y sus familiares. Resultados: Se identificó una variante con cambio de sentido (p.Val647Met, c.1939G>A) en ambos casos, y ambos eran homocigotos con respecto a Met. También se observó esta mutación en 3 pacientes adicionales, 2 homocigotos y uno heterocigoto compuesto con la mutación del intrón 9. Esta nueva mutación del SLC12A3 parece ser característica de los pacientes con SG de etnia gitana y se relacionó con el mismo haplotipo en todos los casos, lo que indica un origen fundador. Todos los pacientes presentaron rasgos bioquímicos propios del SG. Conclusión: Informamos de una segunda mutación fundadora en los pacientes con SG de etnia gitana. El cribado genético directo de esta mutación facilitará la determinación de las características de los pacientes con resultados negativos en la mutación del intrón 9+1G>T, que es más frecuente.

Abstract Background: Gitelman's syndrome (GS) is an autosomal recessive disorder caused by mutations in the SLC12A3 gene. GS is characterized by hypokalaemic metabolic alkalosis, hypomagnesemia and hypocalciuria. Most of the reported patients of Roma ancestry are homozygous for an SLC12A3 intron 9 frameshifting mutation (c.1180+1G>T). Some forms of Bartter's syndrome result from mutations in the CLNCKB gene and clinically overlap with GS. Objectives: To characterize a second SLC12A3 mutation in Roma patients negative for the intron 9 variant. Methods: SLC12A3 and CLNCKB genes were analyzed by next-generation sequencing in two Spanish and Greek gypsy patients who were negative for the intron 9 splicing mutation. Sanger sequencing was performed to confirm the putative mutations in patients and family members. Results: We identified a missense variant (p.Val647Met, c.1939G>A) in both cases, and both were homozygous for Met. This mutation was also found in three additional patients; two homozygous and one heterozygous compound with the intron 9 splicing mutation. This new SLC12A3 mutation seems to be characteristic of gipsy GS patients and was linked to the same haplotype in all cases, supporting a founder origin. All the patients showed biochemical features characteristic of GS. Conclusion: We report a second founder mutation among GS patients of Roma ethnic background. The direct screening of this mutation would facilitate the characterization of patients who are negative for the more common intron 9 +1G>T mutation.

https://doi.org/10.1016/j.nefro.2017.01.007

Ajustes en la estimación de carbono orgánico por el método de Calcinación en molisoles del sudoeste bonaerense
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Martínez, Juan Manuel

; Duval, Matías E

; López, Fernando M

; Iglesias, Julio O

; Galantini, Juan A

Ciencia del suelo

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jun 2017, Volume 35 N. 1 Pages 171 - 180

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

Soil organic carbon (SOC) quantification is crucial for understanding the cycling in the terrestrial ecosystems. It is important to use methodologies of easily implementation that determine the SOC properly. The aims of this study were to determine: i) the optimal temperature and time to maximize the prediction of SOC and ii) a suitable conversion factor (fc) to estimate the SOC by loss-on-ignition method (MC) in Mollisols of the southwest Buenos Aires Province (SOB). During 2010 and 2011, seventy plots under no-tillage located in the SOB, Argentina, were sampled at 0-20 cm depth. Soil organic carbon values determined by dry combustión (CS) in an elemental analyzer were considered as reference values. Soil organic matter (OM) values were determined by MC in a muffle furnace at different temperatures (360, 430, 550 and 600 °C) and times (during 2 and 4 hours). No significant interactions were detected between both factors. Significant effect of different temperatures (p<0.001), while, no significant effect of calcination time (p=0.66) were detected. Linear regressions between SOC and OM at different temperatures showed significant relationships (p <0.001) with high coefficients of determination (R² =0.91-0.95). The best prediction of SOC was found with 550 °C temperature (R² = 0.95). The fc was 2.2, which would indicate that in these soils the C content in OM was 45%. These results suggest that MC with an adequate fc, is an easily implementable protocol that provides estimation of SOC comparable with the reference CS method.

La cuantificación del carbono orgánico del suelo (COS) es crucial para comprender su ciclado en los ecosistemas terrestres. Es importante la utilización de metodologías de fácil implementación que determinen el COS correctamente. Los objetivos de este trabajo fueron determinar: i) la temperatura y la duración óptima que maximice la predicción del COS a través del método de calcinación (MC) y, ii) un factor de conversión (fc) para estimar el COS en suelos Molisoles del sudoeste bonaerense (SOB). Durante los años 2010 y 2011, se tomaron muestras a una profundidad de 0-20 cm en setenta lotes bajo siembra directa ubicados en el SOB, Argentina. La determinación del COS por combustión seca (CS) en un analizador elemental se tomó como valor de referencia. La materia orgánica (MO) se determinó por MC en una mufla a diferentes temperaturas (360, 430, 550 y 600 °C) y tiempos (durante 2 y 4 horas). Independientemente del tiempo de calcinación, los valores de MO se incrementaron con el aumento de la temperatura. No se detectaron interacciones entre los factores tiempo y temperatura. Se hallaron efectos significativos de las diferentes temperaturas (p<0,001) y ningún efecto del tiempo (p=0,66). Las regresiones lineales entre COS y MO a diferentes temperaturas demostraron relaciones significativas (p<0,001) con elevados coeficientes de determinación (R² =0,91-0,95). La mejor predicción del COS se halló con la temperatura de 550 °C (R² =0,95). El fc obtenido fue de 2,2, lo cual estaría indicando que en estos suelos el contenido de carbono (C) en la MO es de 45%. Estos resultados sugieren que el MC junto con un fc adecuado, constituyen un protocolo de fácil implementación que brinda estimación del COS comparable con el método de referencia de CS.

10.

Impacto de la medicina regenerativa en angiología. Experiencia cubana
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Hernández Ramírez, Porfirio

; Artaza Sánz, Heriberto

; Aparicio Suárez, José Luis

; Cruz Tamayo, Fernando

; Díaz Díaz, Antonio Jesús

; Fernández Delgado, Norma

; Fernández Águila, Julio

; Gámez Pérez, Anadely

; González Iglesias, Ana Iris

; León Amado, Lisset

Revista Cubana de Angiología y Cirugía Vascular

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jun 2017, Volume 18 N. 1 Pages 3 - 18

Abstract: Es | Text: Es | PDF: Es

11.

Practical aspects of high resolution esophageal manometry
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Ruiz-de-León-San-Juan, Antonio

; Ciriza-de-los-Ríos, Constanza

; Pérez-de-la-Serna-Bueno, Julio

; Canga-Rodríguez-Valcárcel, Fernando

; Estremera-Arévalo, Fermín

; García-Sánchez, Raquel

; Walter Huamán-Ríos, Jose

; Pérez-Fernández, María Teresa

; Santander-Vaquero, Cecilio

; Serra-Pueyo, Jordi

; Sevilla-Mantilla, Concepción

; Barba-Orozco, Elisabeth

; Bosque-López, María José

; Casabona-Francés, Sergio

; Carrión-Bolorino, Silvia

; Castillo-Grau, Pilar

; Delgado-Aros, Silvia

; Domínguez-Carbajo, Ana Belén

; Fernández-Orcajo, Pilar

; García-Lledó, Javier

; Gigantó-Tomé, Froilán

; Iglesias-Picazo, Rosa

; Lacima-Vidal, Gloria

; López-López, Pilar

; Llabrés-Rosselló, Magdalena

; Mas-Mercader, Pilar

; Mego-Silva, Marianela

; Mendarte-Barrenetxea, María Usua

; Miliani-Molina, Carlos

; Oreja-Arrayago, Milagros

; Sánchez-Ceballos, Francisco

; Sánchez- Prudencio, Sandra

Revista Española de Enfermedades Digestivas

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feb 2017, Volume 109 N. 2 Pages 91 - 105

Abstract: Es En | Text: Es En | PDF: Es | PDF: En

La manometría esofágica de alta resolución (MAR) está en fase de desarrollo, como se evidencia por las diferentes clasificaciones de Chicago. Con el fin de unificar criterios en algunos aspectos prácticos con limitada evidencia científica se llevó a cabo la Primera Reunión Nacional de Consenso en Manometría de Alta Resolución del Grupo Español de Motilidad Digestiva, en la que participaron un amplio grupo de expertos. Las propuestas se basaron en una encuesta previa con 47 preguntas, la exhaustiva revisión de la bibliografía disponible y la experiencia de los participantes. Se plantearon aspectos metodológicos sobre criterios de análisis poco definidos de algunos nuevos parámetros de alta resolución y otros aspectos no considerados, como la actividad espontánea o las ondas secundarias, elaborándose conclusiones finales con utilidad práctica.

High resolution esophageal manometry (HRM) is currently under development as can be seen in the various Chicago classifications. In order to standardize criteria in certain practical aspects with limited scientific evidence, the First National Meeting for Consensus in High Resolution Manometry of the Spanish Digestive Motility Group took place, bringing together a wide group of experts. The proposals were based on a prior survey composed of 47 questions, an exhaustive review of the available literature and the experience of the participants. Methodological aspects relating to the poorly defined analysis criteria of certain new high resolution parameters were discussed, as well as other issues previously overlooked such as spontaneous activity or secondary waves. Final conclusions were drawn with practical applications.

https://doi.org/10.17235/reed.2016.4441/2016

12.

Estudio multicéntrico sobre la epidemiologia de la Esofagitis Eosinofílica Pediátrica en América Latina
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Pierre, Reinaldo

; Vieira, Mario

; Vázquez Frías, Rodrigo

; Nimoniya, Inés

; Messere, Gabriela

; Daza, Wilson

; Dadan, Silvana

; Higuera, Michelle

; Sifontes, Leida

; Harris, Paul

; Gana, Juan Carlos

; Rodríguez, Magaly

; Vasquez, Margarita

; González, Mónica

; Rivera, Juan

; Gonzales, José

; Angulo, Diana Karim

; Cetraro, Maria Delfina

; Del Compare, Mónica

; López, Karolina

; Navarro, Dianora

; Calva, Roberto

; Wagener, Marta

; Zablah, Roberto

; Carias, Ailim

; Calderón, Otto

; Vera-Chamorro, José Fernando

; Toca, María del Carmen

; Dewaele, Maria Rita

; Iglesias, Claudio

; Delgado, Laura

; León, Keira

; Hassan, Isaac

; Ussher, Federico

; Follett, Francisco

; Bernedo, Viviana

; Grinblat, Victor

; Agüero, Nora

; Oviedo, Cesar

; García, Angel Gustavo

; Salazar, Abel

; Coello, Pedro

; Furnes, Raquel

; Menchaca, Mario

; Fernández, Maryaurora

; Khoury, Antoinette

; Rojo, Claudia

; Fernández, Sergio

Gen

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dec 2016, Volume 70 N. 4 Pages 125 - 130

Abstract: Es En | Text: Es En | PDF: Es | PDF: En

Objetivo: Evaluar las características epidemiológicas de un grupo de pacientes pediátricos con esofagitis eosinofílica (EEo) y las modalidades de tratamiento empleadas en Latinoamérica. Pacientes y métodos: Estudio multicéntrico, observacional, transversal. Se aplicó una encuesta a 36 Centros de Gastroenterología y Endoscopia Pediátrica de 10 países latinoamericanos con la finalidad de obtener información socio-demográfica y datos sobre el tratamiento utilizado para el manejo de los casos evaluados durante el periodo 2014-2016. Resultados: 372 casos de EEo pediátrica fueron evaluados durante el periodo 2014-2016 y 108 casos (29%) correspondieron al trimestre Abril-Junio 2016. 46,72% de los casos pertenecían al grupo de edad escolar y 71,8% consultaron por disfagia. 87,2% de los pacientes fueron manejados con dieta, 55,3% esteroides deglutidos (12,8% en monoterapia) y 6% recibió montelukast. No hubo reporte de pacientes en terapia con agentes biológicos. Conclusiones: los resultados sugieren un predominio del sexo masculino con una mayor incidencia de la enfermedad en la edad escolar y la adolescencia. Las manifestaciones clínicas más frecuentes son disfagia, vómitos y síntomas de reflujo gastroesofágico. El tratamiento más indicado por los especialistas en América Latina es la dieta seguido del uso de esteroides deglutidos. Los IBP también son ampliamente utilizados como terapia coadyuvante. Un estudio de prevalencia a nivel continental es necesario para evaluar el comportamiento de la enfermedad en diferentes regiones de América Latina.

Aims: To evaluate epidemiological features of pediatric patients with eosinophilic esophagitis in Latinamerica and therapeutical options indicated by pediatric gastroenterologists in our continent. Patients and methods: multicenter, observational, transversal study. 36 Centers of Pediatric Gastroenterology and Endoscopy from 10 latinamerican countries participated giving clinical and sociodemographic information about pediatric patients with EoE diagnosed and treated during the last two years (study period). Results: 372 cases of pediatric EoE were evaluated during period 2014-2016 (108 cases were evaluated during trimester April-June 2016). 46,72% of cases were school age children, with dysphagia been the main clinical symptom in 71,8% of patients. 87,2% of patients received diet as a main indication of treatment, 55,3% received swallowed steroids (12,8% as monotherapy) and 6% were treated with montelukast among others. There were no reports of patients under treatment with biological drugs. Conclusions: epidemiological features of our study group suggest a higher prevalence of pediatric EoE in male school age children and adolescents. Most frecuent clinical symptoms are dysphagia, vomiting and gastroesophageal reflux symptoms. Treatment is based mainly on diet and swallowed steroids. A continental prevalence study is necessary to evaluate the behavior of the disease in different regions of Latinamerica.

13.

Spontaneous retroperitoneal hematoma in a patient under anticoagulant agents presenting as upper gastrointestinal bleeding
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Carrilero-Zaragoza, Gabriel

; Egea-Valenzuela, Juan

; Moya-Arnao, María

; Muñoz-Tornero, María

; Jijón-Crespín, Roxanna

; Tomás-Pujante, Paula

; Iglesias-Jorquera, Elena

; Parra-García, Josefa

; Sánchez-Velasco, Eduardo

; Pereñíguez-López, Ana

; Miras-López, Manuel

; Fuster-Quiñonero, Matilde

; Carballo-Álvarez, Fernando

Revista Española de Enfermedades Digestivas

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dec 2016, Volume 108 N. 12 Pages 817 - 818

Abstract: Es En | Text: Es En | PDF: Es | PDF: En

Presentamos el caso de una mujer de 44 años de edad con antecedentes de abortos de repetición y síndrome de Budd-Chiari secundario a una mielofibrosis primaria en tratamiento anticoagulante. Consulta por melenas y astenia, presentando anemización progresiva. En una gastroscopia inicial se aprecia una compresión extrínseca a nivel supraampular de segunda porción duodenal, con una úlcera asociada en cara posterior de bulbo y primera rodilla. Posteriormente se diagnostica mediante una tomografía computarizada de un hematoma retroperitoneal espontáneo secundario a anticoagulación. Se trata con drenaje percutáneo y retirada de anticoagulación con buena respuesta inicial. No obstante, presenta complicaciones trombóticas (trombosis subclavia y yugular) y se reintroducen los anticoagulantes con dosis en el límite bajo del rango terapéutico.

We present the case of a 44-year-old woman with past history of repeated miscarriage and Budd-Chiari syndrome secondary to primary myelofibrosis. Because of this she was under treatment with oral anticoagulant agents. The patient was admitted in hospital as she presented with gastrointestinal bleeding (melena), asthenia and progressive anemia. In an initial upper endoscopy an extrinsic duodenal compression associated with an ulcer on the posterior face of the first portion of duodenum and upper duodenal knee was observed. In the following days a huge spontaneous retroperitoneal hematoma due to anticoagulation was diagnosed by computed tomography. This was treated with a percutaneous drainage and withdrawal of the antithrombotic drugs. The evolution of the patient was initially satisfactory but she suffered subclavian and jugular vein thrombosis, and reintroduction of anticoagulant agents at the lowest therapeutic doses was required.

https://doi.org/10.17235/reed.2016.3897/2015

14.

Potent inhibition of Western Equine Encephalitis virus by a fraction rich in flavonoids and phenolic acids obtained from Achyrocline satureioides
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Sabini, María Carola

; Cariddi, Laura Noelia

; Escobar, Franco Matías

; Mañas, Fernando

; Comini, Laura

; Iglesias, Delvis

; Larrauri, Mariana

; Montoya, Susana Núñez

; Sereno, José

; Contigiani, Marta Silvia

; Cantero, Juan José

; Sabini, Liliana Inés

Revista Brasileira de Farmacognosia

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oct 2016, Volume 26 N. 5 Pages 571 - 578

Abstract: En | Text: En | PDF: En

ABSTRACT Achyrocline satureioides (Lam.) DC. Asteraceae, ‘marcela del campo', possess several pharmacological properties. Previously we reported antiviral activity of an aqueous extract of A. satureioides against an alphavirus, Western Equine Encephalitis virus. Alphaviruses are highly virulent pathogens which cause encephalitis in humans and equines. There are no effective antiviral to treat its infections. The aim of this study was to evaluate in vitro cytotoxic and antiviral activities against Western Equine Encephalitis virus of five water extract chromatographic fractions from A. satureioides and identify the main compounds of the bioactive fraction. Also, it was to assess in vivo cytogenotoxic ability of the active fraction. Cytotoxicity studies revealed low toxicity of the most of fractions in Vero and in equine peripheral blood mononuclear cells. Antiviral studies showed that the water crude extract – Sephadex LH 20 – fraction 3 MeOH–H2O (Fraction 3) was active against Western Equine Encephalitis virus with Effective Concentration 50% = 5 µg/ml. Selectivity Indices were 126.0 on Vero and 133.6 on peripheral blood mononuclear cells, four times higher than aqueous extract selectivity index. Regarding the mechanism of action we demonstrated that F3 exerted its action in intracellular replication stages. Further, fraction 3 showed important virucidal action. Fraction 3 contains, in order of highest to lowest: chlorogenic acid, luteolin, 5,7,8-trimethoxyflavone, 3-O-methylquercetin and caffeic acid. Fraction 3 did not induce in vivo toxic nor mutagenic effect. Therefore, it is safe its application as antiviral potential. Further studies of antiviral activity in vivo will be developed using a murine model.

https://doi.org/10.1016/j.bjp.2016.05.004

15.

Relação treonina: lisina digestíveis na dieta de poedeiras leves de 42 a 58 semanas de idade
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PASTORE, Silvana Marques

; ALBINO, Luiz Fernando Teixeira

; GOMES, Paulo Cezar

; OLIVEIRA, Will Pereira de

; SILVA, Eliane Aparecida da

; VIANA, Gabriel da Silva

; MENDES, Melissa Fabíola dos Santos Alves

; ALVES, Warley Junior

; IGLESIAS, Erick

Revista Brasileira de Saúde e Produção Animal

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sep 2016, Volume 17 N. 3 Pages 438 - 447

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

SUMMARY This study was conducted to determine the ideal ratio of digestible threonine: lysine in diets for laying hens at 42 to 58 weeks of age. Two hundred forty Hy Line W-36 laying hens were used at 42 weeks of age for 16 weeks. The treatments were distributed in a completely randomized design with eight replicates and six birds each. The experimental diets were formulated with five levels of digestible threonine (0.461; 0.515; 0.569; 0.622 and 0.676%) providing the five ratio of digestible threonine: lysine (60; 67; 74; 81 and 88%) studied. The variables analyzed were: egg production; feed intake; lysine intake; threonine intake; mass egg; average egg weight; lysine use efficiencies by mass and produced eggs; feed conversion per mass and dozen eggs; Average weights yolk, albumen and shell; weight gain and final body weights of birds; and nitrogen balance. The digestible threonine: lysine ratio in the diet did not influence the analyzed variables except consumption of threonine which showed a linear effect. The ideal ratio of digestible threonine: lysine in diets for white laying hens at 42 to 58 weeks of age is 60%, which corresponds to the level of 0.461% of digestible threonine in the diet and daily intake of digestible threonine 446mg/bird.

RESUMO Este estudo foi realizado para determinar a relação ideal de treonina:lisina digestíveis para poedeiras leves no período de 42 a 58 semanas de idade. Foram utilizadas 240 poedeiras Hy Line W-36 com 42 semanas de idade durante 16 semanas. Os tratamentos foram distribuídos em delineamento inteiramente casualizado, com oito repetições e seis aves por unidade experimental. As dietas experimentais foram formuladas com cinco níveis de treonina digestível (0,461; 0,515; 0,569; 0,622 e 0,676%) proporcionando as cinco relações treonina:lisina digestíveis (60; 67; 74; 81 e 88%) estudadas. As variáveis analisadas foram: produção de ovos; consumo de ração, de lisina e de treonina; massa e peso médio dos ovos; eficiências de utilização da lisina por massa e ovos produzidos; conversões alimentares por massa e dúzia de ovos; pesos médios de: gema, albúmen e de casca; ganho de peso; peso corporal final das aves; e balanço de nitrogênio. As relações treonina:lisina digestíveis na dieta não influenciaram as variáveis analisadas, exceto o consumo de treonina que apresentou efeito linear. A relação ideal de treonina:lisina digestíveis na dieta para galinhas poedeiras leves de 42 a 58 semanas de idade é de 60%, que corresponde ao nível de 0,461% de treonina digestível na dieta e ao consumo diário de treonina digestível de 446mg/ave.

https://doi.org/10.1590/S1519-99402016000300010

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