Results: 5
#1
au:Gracia-Medina, Elías
Filters
Order by
Page
of 1
Next
1.
Lymphocyte Subsets in Defense Against New Pathogens in Patients With Cancer
Facebook Twitter

Facebook Twitter
- Other social networks
- Google+
- StambleUpon
- CiteULike
- Mendeley
- Other networks
- Metrics
Arango-Prado, María del Carmen
; Villegas-Valverde, Carlos A.
; Torres-López, Griselda
; Soto-Pardeiro, Pilar
; Suárez-Reyes, Anamary
; Faxas-García, María E.
; Diéguez-Rodríguez, Vivian
; Gracia-Medina, Elías
; Esperón-Noa, Roberto
; del Castillo-Bahi, Ramón
; Méndez-Rosabal, Ariadna
; Curbelo-Alfonso, Luis
.












Abstract INTRODUCTION Immunity in cancer patients is modified both by the cancer itself and by oncospecific treatments. Whether a patient’s adaptive immunity is impaired depends on their levels of naive lymphocytes and other cell populations. During the COVID-19 pandemic, cancer patients are at greater risk of progressing to severe forms of the disease and have higher mortality rates than individuals without cancer, particularly while they are receiving cancer-specific therapies. An individual’s protection against infection, their response to vaccines, and even the tests that determine the humoral immune response to SARS-CoV-2, depend on lymphocyte populations, meriting their study. OBJECTIVE Estimate blood concentrations of lymphocytes involved in the immune response to new pathogens in cancer patients. METHODS We carried out an analytical study of 218 cancer patients; 124 women and 94 men, 26–93 years of age, who were treated at the National Oncology and Radiobiology Institute in Havana, Cuba, March–June, 2020. Patients were divided into five groups: (1) those with controlled disease who were not undergoing cancer-specific treatment; (2) those undergoing debulking surgery; (3) patients undergoing chemotherapy; (4) patients undergoing radiation therapy and (5) patients currently battling infection. We evaluated the following peripheral blood lymphocyte subsets via flow cytometry: B lymphocytes (total, naive, transitional, memory, plasmablasts and plasma cells); T lymphocytes (total, helper, cytotoxic and their respective naive, activated, central memory and effector memory subsets); and total, secretory and cytotoxic natural killer cells and T natural killer cells. We also estimated neutrophil/lymphocyte ratios. Lymphocyte concentrations were associated with controlled disease and standard cancer therapy. For variables that did not fall within a normal distribution, ranges were set by medians and 2.5–97.5 percentiles. The two-tailed Mann–Whitney U test was used to measure the effect of sex and to compare lymphocyte populations. We calculated odds ratios to estimate lymphopenia risk. RESULTS All cancer patients had lower values of naive helper and cytotoxic T lymphocyte populations, naive B lymphocytes, and natural killer cells than normal reference medians. Naive helper T cells were the most affected subpopulation. Memory B cells, plasmablasts, plasma cells, activated T helper cells, and cytotoxic central memory T cells were increased. Patients undergoing treatment had lower levels of naive lymphocytes than untreated patients, particularly during radiation therapy. The risk of B lymphopenia was higher in patients in treatment. The odds ratio for B lymphopenia was 8.0 in patients who underwent surgery, 12.9 in those undergoing chemotherapy, and 13.9 in patients in radiotherapy. CONCLUSIONS Cancer and conventional cancer therapies significantly affect peripheral blood B lymphocyte levels, particularly transitional T helper lymphocytes, reducing the immune system’s ability to trigger primary immune responses against new antigens.
2.
SMILE en linfoma de células NK/T extranodal en recaída
Facebook Twitter

Facebook Twitter
- Other social networks
- Google+
- StambleUpon
- CiteULike
- Mendeley
- Other networks
- Metrics
Martínez Avila, Daniel Ricardo
; Gracia Medina, Elías
; Martínez Espinosa, Lázara Yaniet
; Medina Pérez, Víctor Manuel
; Mir Espinosa, Yanelis Longina
.





Revista Cubana de Hematología, Inmunología y Hemoterapia
- Journal Metrics
ABSTRACT Introduction: Extranodal lymphoma of NK / T cells, nasal type is an aggressive variety that occurs most frequently in East Asia and Latin America. The SMILE treatment regimen, based on dexamethasone, methotrexate, ifosfamide, L-asparaginase and etoposide, showed adequate objective response rates in phase 1/2 studies. Objective: to present the first report of the application of the SMILE protocol in Cuba. Case presentation : 47-year-old white patient who presented early relapse of extranodal lymphoma of nasal NK / T cells in soft parts of the left anterior wall of the thorax. He received SMILE chemotherapy for 4 cycles and the evaluation at the end of the treatment showed that there was a complete response of the disease.
RESUMEN Introducción: El linfoma extranodal de células NK/T, tipo nasal es una variedad agresiva que se presenta con mayor frecuencia en Asia Oriental y América Latina. El régimen de tratamiento SMILE, basado en dexametasona, metotrexato, ifosfamida, L-asparaginasa y etopósido, mostró tasas de respuestas objetivas adecuadas en estudios de fase 1/2. Objetivo: presentar el primer reporte de la aplicación del protocolo SMILE en Cuba. Presentación del caso: paciente de 47 años de edad, blanca que presentó recaída temprana de linfoma extranodal de células NK/T tipo nasal en partes blandas de la pared anterior izquierda del tórax. Recibió quimioterapia SMILE por 4 ciclos y en la evaluación al final del tratamiento se comprobó que hubo una respuesta completa de la enfermedad.
3.
Supervivencia de pacientes con linfoma no-Hodgkin y síntomas neurológicos según inmunofenotipo del líquido cefalorraquídeo
Facebook Twitter

Facebook Twitter
- Other social networks
- Google+
- StambleUpon
- CiteULike
- Mendeley
- Other networks
- Metrics
Villegas Valverde, Carlos Agustín
; Suárez Reyes, Anamary
; Torres López, Griselda
; González Madruga, Tamara
; Martínez Espinosa, Lázara Yinet
; Gracia Medina, Elías Antonio
; Arango Prado, María del Carmen
.







Revista Cubana de Hematología, Inmunología y Hemoterapia
- Journal Metrics
ABSTRACT Introduction: When non-Hodgkin lymphomas infiltrate the central nervous system increases mortality. The diagnosis of this infiltration can be made by the study of cerebrospinal fluid using flow cytometry, with a higher sensitivity than conventional cytology. Objective: To estimate the relationship between the cellular immunophenotype of the cerebrospinal fluid and the overall survival of patients with non-Hodgkin lymphoma and neurological symptoms. Methods: An analytical and prospective study was conducted in 15 patients with confirmed diagnosis of non-Hodgkin lymphoma and neurological symptoms, with negative cytology of the cerebrospinal fluid. Patients cared at Oncology Department of the National Institute of Oncology and Radiobiology, during the years 2017-2018. The immunophenotype was characterized by multiparametric flow cytometry. Results: 60.0% of the patients was female and 53.4% older than 60 years. There was an overall mortality of 26.7%. 17 immunophenotypes were found, 58.9% of them was normal, 23.4% reactive and 17.7% suspected of malignancy. Overall survival advantage was obtained in patients with cerebrospinal fluid with normal immunophenotype (HR 0.04). Conclusions: Flow cytometry could discriminate cells suspected of malignancy, in patients whose cytologies were negative. The presence in the cerebrospinal fluid of atypical cells, pleocytosis and a high lymphocyte-monocyte index were associated with a lower overall survival.
RESUMEN Introducción: Los linfomas no-Hodgkin pueden infiltrar el sistema nervioso central y producir síntomas neurológicos, lo cual incrementa la mortalidad. El diagnóstico de esta infiltración se puede realizar mediante el estudio del líquido cefalorraquídeo por la técnica de citometría de flujo, con una mayor sensibilidad que la citología convencional. Objetivo: Estimar la supervivencia global de pacientes con Linfoma no-Hodgkin y síntomas neurológicos según el inmunofenotipo celular del líquido cefalorraquídeo. Métodos: Se realizó un estudio analítico y prospectivo en 15 pacientes con diagnóstico confirmado de linfoma no-Hodgkin y síntomas neurológicos, con citología negativa del líquido cefalorraquídeo, tratados en el servicio de oncología del Instituto Nacional de Oncología y Radiobiología, durante los años 2017 y 2018. El inmunofenotipo fue caracterizado mediante citometría de flujo multiparamétrica. Resultados: El 60,0 % de los pacientes fue del sexo femenino y el 53,4 % mayor de 60 años. Hubo una mortalidad del 26,7 %. Se realizaron 17 inmunofenotipos, el 58,9 % fue normal, el 23,4 % reactivo y el 17,7 % sospechoso de malignidad. La supervivencia global fue mayor en pacientes con líquido cefalorraquídeo con inmunofenotipo normal (HR. 0.04). Conclusiones: La citometría de flujo pudo discriminar células sospechosas de malignidad, en pacientes cuyas citologías fueron negativas. La presencia en el líquido cefalorraquídeo de células atípicas, de pleocitosis y de un índice de linfocito-monocito alto se asoció con una supervivencia global menor.
4.
Trabajos de investigación presentados en el L Congreso Mexicano de Anestesiología: Chihuahua 2017. México
Facebook Twitter

Facebook Twitter
- Other social networks
- Google+
- StambleUpon
- CiteULike
- Mendeley
- Other networks
- Metrics
Ríos Medrano, Alea Fernanda
; Herrero Trujillano, Manuel
; Robles López, Maria Decire
; Rodríguez Barajas, Ruben
; Gutiérrez-Martínez, Paola Virginia
; Ramírez-Gómez, Melba
; Olvera-Hernández, Jesus Arnoldo
; Márquez Noyola, Elizabeth Alicia
; Almonte de León, Héctor
; Hernández Mancilla, Arturo
; Castro Salinas, José Ernesto
; Medrano-Duarte, Olga Abigahil
; Ramírez-Mendoza, Karla
; Rodriguez-Nieves, Georgina Monserrat
; Pareces Ríos, Adriana
; Ruiz-Rubio, Yolanda
; Hernández-Santiago, María Guadalupe
; Ramírez Mendoza, Karla
; Medrano Duarte, Olga Abigahil
; Martínez-Alpuche, Rocío Adriana
; Valenzuela-Priego, Francisco
; Álvarez-Santiago, José Heriberto
; Lugo-Rodríguez, Julian
; Betancourt-Sandoval, Alonso
; Prince-Angulo, Silvia Annel
; Martínez-Felix, Israel
; Salazar-Castro, Laura
; Espinazo-Quintero, Erendira
; Otañez, Monica Thalia
; Priego, Gloria
; Alzate, Ana Lizette
; Salazar, Laura Elena
; Nieblas, Mariela
; Martinez, Israel
; Alvarez-Betancourt, Ana Elsa
; Sánchez-Hernández, Eloy
; Romo-Serrano, Erika
; Rodríguez-Jauregui, Adriana
; Díaz-Aceves, Erica Raquel
; Arteaga-Trejo, Jaime
; Rodríguez-Jáuregui, Adriana
; Robles-Lopéz, María Decire
; Ibarra-González, María Livier
; Alvarez-Betancourt, Ana Elsa
; Díaz-Aceves, Erica Raquel
; Arteaga-Trejo, Jaime
; Santana-Sonora, Beatriz Alejandra
; Prince-Angulo, Silvia Annel
; Sandoval-Rivera, Arturo Guadalupe
; Camacho-López, Jesús Erick
; Alzate-Moctezuma, Ana Lizette
; Valencia-Echávarri, Andrea
; Canales-Bonilla, Carlos Patricio
; Ramos-Hernández, Julia Demetria
; Flores-Posada, Jesus Jonathan
; Muñoz Garcia, Aleyda
; Osorio Santiago, Maria Areli
; Lopez Cartita, Victor
; Ortega, Julio
; Fuentes García, Víctor E
; Moyao García, Diana
; Villars Zamora, Elvia Gabriela
; Prince Angulo, Silvia Annel
; Gerardo Angulo, Alma Ruth
; Martinez Felix, Israel
; Ayala Camargo, Yuridia
; Esquer de la Rosa, Jaquelyn Roxana
; Trapaga Millares, Yazmin
; Sánchez León, Claudia Elena
; Vásquez Puente, Felipe
; Rojo Medina, Victor Javier
; Urias Romo de vivar, Emma Gabriela
; Prince Angulo, Silvia Annel
; Ojeda Ramos, Joel
; Caceres Figueroa, Leonardo Andres
; Martinez Reyes, Maria Fernanda
; Contreras Ramírez, Nathalie
; Martínez Barreto, Nelly
; Ruelas León, Berenice
; Reyes Salgado, Karla
; Ruvalcaba Sánchez, Rafael
; Núñez Valencia, Carolina
; Escamilla Asiain, Gabriela
; Carranza-Cortés, José Luis
; Puga-Flores, Eva del Carmen
; Jiménez-Cardona, María Beatriz
; Puga-García, Diana Marisol
; Alcaraz-Ramos, Rosina
; Martinez-Delgado, Olinda
; Zamudio-Gracia, Carlos Amador
; Mireles Vega, Elizabeth
; Hernández López, Clara
; Ceballos Niño, Jose Luis
; Carreño Caballero, Jessica
; Montiel Jarquín, Álvaro José
; López García, Ingrid
; Serrano Cuevas, Beatriz
; Martinez Marin, Dolores Guillermina
; Díaz-Aceves, Erica Raquel
; Romo-Serrano, Erika
; Campechanos-Asencio, María de los Ángeles
; Rodríguez-Jáuregui, Adriana
; Betancourt-Álvarez, Ana Elsa
; Arteaga-Trejo, Jaime
; Arteaga-Trejo, Jaime
; Romo-Serrano, Erika
; Rios-Navarro, Ramón Alejandro
; Rodriguez-Jauregui, Adriana
; Alvarez-Betancourt, Ana Elsa
; Diaz Aceves, Érica Raquel
; Calleja-Zenteno, Liliana
; Fernández-Vázquez, María Urbelina
; Carreño-Caballero, Jessica
; Serrano Cuevas, Beatriz
; Montiel Jarquín, Álvaro José
; Carreño- Caballero, Jessica
; Cortes- Pineda, Claudia
; Fernández-Vázquez, María Urbelina
; Hernández-Domínguez, Juan
; Serrano-Cuevas, Beatriz
; Ruiz- Luna, Mayra
; Gómez-Moreno, Julieta Berenice
; Hernández-Santiago, Maria Guadalupe
; Ruiz-Rubio, Yolanda
; Ruiz-Serrano, Ana Cristina
; Medina-Flores, Aleida
; Sánchez Torres, Claudia
; Osorio Santiago, María Areli
; Lee, Angel
; Correa-Ovis, Jose Francisco
; Priego-Martínez, Luis Alberto
; Valencia-Carrillo, Miguel
; Sánchez-Arteaga, Sofia
; Cruz-Márquez, Abraham Josué
; Duran-Zamora, Karina Aurora
; Corral-Guerrero, Sergio Francisco
; Arce Bojorquez, Brisceyda
; Medina, Francisco
; Felix, Pavel
; Estrada, Haydeé Gloria
; González-Herrera, Francisco Javier
; Zepeda Olivera, Silvia
; Pablo-Yañez, Julio Cesar
; Colores Velazquez, Julio Cesar
; Calva Maldonado, Miguel
; Veyna Rocha, Sissy Barubi
; Veyna Rocha, Abraham Irishd
; Rodríguez-Rodríguez, María Guadalupe
; Castillo- Rodriguez, Juan Orlando
; Martínez-Figueroa, Brenda Paola
; Romero Guillén, Lorena Priscila
; Pavía Vega, Susy Sáez
; Jiménez Siles, María Eugenia
; Hurtado Reyes, Ignacio Carlos
; Rojas Zarco, Eder Marcelo
; Sánchez Tapia, Mario Alberto
; Villicaña-Ayala, Carolina
; Díaz-Aguilar, Marco Antonio
; Apolinar Jiménez, Evelia
; García-Parra Pérez, Paola Carolina
; García-Parra Pérez, Natalia Cristina
; Yee-Rendón, Zumey
; Valle-Leal, Jaime Guadalupe
; Reyes-Jiménez, Gerardo Antonio
; Ortiz-Magallanes, Elías
; Sanchez-Aguilar, Maricela
; Mota-Figueroa, Roanne Patrician
; Espinosa-Tadeo, Aldo Ernesto
; Díaz-Hernández, Alejandro Eduardo
; Cendón-Ortega, María Mercedes
; Ortega-Ponce, Fabiola Estela Elizabeth
; Romero-Guillen, Lorena Priscila
; Cruz Castañedo, Greta
; Constantino-Rivera, Luis Armando
; Gordillo-Paniagua, Jorge Alberto
; Contreras-Ramírez, Nathalie
; Bernal-Zambrano, Luis Omar
; Flores-Alvarado, Rosa María
; Ferrera-Sarquís, María Aurora
; Espino Vega, Ana Frain
; Guillen-Narváez, María del Rocio
; López-García, Rocío Angélica
; Martínez-Sánchez, Angélica
; Huerta-Beltrán, Juana Geraldine
; Gómez-Rojas, Juan Pablo
; Rivera-Ruiz, Rodolfo Eduardo
; Ramírez Reyes, Liliana Georgina
; Muñoz Martínez, Raúl
; Martínez-Morales, Nayeli Noemi
; Mariscal-Cervantes, Beatriz
; Chávez-Barragán, Oscar Fernando
; Barrera-de León, Juan Carlos
; Carrillo-Guerra, Valentin
; Huitrón-Hernández, José Alonso
; De la Rosa-Fabián, Viviana Marysela
; Zertuche-Méndez, David Ricardo
; Riquelme Holguin, Karla Talia
; Gutierrez Beltran, Maria del Refugio
; Martinez-Tapia, Maria Elena
; Amezquita Esparza, Monica
; Portillo Villalobos, Samantha
; Díaz Solís, Erick Iván
; Estrada Utrera, Maria Sandra
; Islas Ruz, Félix Gilberto
; Pérez Díaz, Roberto
; Chávez-Contreras, Sara Idali
; Zepeda Olivera, Silvia
; Calva-Maldonado, Miguel
; Fragoso-Avilés, Fabían
; Rosa-Moya, Griselda de la
; Ávila-López, Armando
; López Castruita, Victor Manuel
; Manrique Carmona, Luisa Piedad
; Ramírez- Martínez, Elizabeth
; Rojas-Peñaloza, Janeth
; López-Gómez, Antonio
; Veyna Rocha, Abraham Irishd
; Veyna Rocha, Sissy Barubi
; Torres Hernández, Rosa
; Aleman-Ortega, Cristina
; Guevara-Pérez, Alejandra
; Castillo Gamez, Tobias Francisco
; Gutierrez Beltran, María del Refugio
; Martínez Tapia, María Elena
; Alanis Uribe, Karla
; Guerrero Morales, Fernando
; Molina Rodríguez, Gloria
; Gómez Cruz, José Roberto
; Tapia Castro, Gabriela
; Ley, Marcial Luis
; Castro Ortega, Julio
; Martínez, Leo Bruno
; Portugal Moreno, Víctor Hugo
; García Cabello, Luis Manuel
.










































































































































































































































15115 downloads
5.
Incremento del volumen asistencial en el Instituto Nacional de Oncología y Radiobiología entre 1992 y 2000
Facebook Twitter

Facebook Twitter
- Other social networks
- Google+
- StambleUpon
- CiteULike
- Mendeley
- Other networks
- Metrics
The National Institute of Oncology and Radiobiology (INOR in Spanish) is the main care center for cancer patients in the country. The characteristics of cases diagnosed with cancer at INOR from 1992 to 2000 were analyzed. A descriptive study was carried out to make a comparison among cases diagnosed in the three-year periods 1992-1994, 1995-1997 and 1998-2000 respectively, through a frequency distribution analysis of the number of cases by time, sex, age, primary location, clinical stage, treatment and most valid basis for diagnosis. It was found that number of reported cases increased by 65% in less than 10 years; females prevailed over males (60% vs 40%), over 50 years-old patients and cases diagnosed at early stages of the disease predominated; but there was a high percentage of cases without defined staging (31,2%). The main cancer locations were skin, uterus, breast, thyroid and laryx. The need of conducting an organizational study of INOR and the Cancer Care Network in the City of Havana, which will consider the setting of priorities related to care requeriments in surgical areas and in outpatient chemotherapy and will emphasize the particularities of the most frequent cancer locations, was evidenced.
El Instituto Nacional de Oncología (INOR) es el principal centro del país en la atención al paciente oncológico. Se analizaron las características de los casos diagnosticados de cáncer en el INOR entre 1992 y 2000. Se realizó un estudio descriptivo para comparar los casos diagnosticados en los trienios 92-94, 95-97 y 98-2000, mediante un análisis de distribución de frecuencia del número de casos según tiempo, sexo, edad, sitio primario, etapa clínica, tratamiento y base más válida para el diagnóstico. Se halló que la proporción de casos reportados se incrementó en un 65 % en menos de 10 años, predominaron los casos del sexo femenino sobre el masculino 60 vs. 40 %, así como de los pacientes en los grupos de edades mayores de 50 años (68 %) y los casos diagnosticados en etapas tempranas, pero hubo un alto porcentaje de casos sin estadiar (31,2 %). Las principales localizaciones de cáncer fueron piel, cuello de útero, mama, tiroides y laringe. Se evidenció la necesidad de realizar un estudio organizacional del INOR y de la Red Asistencial de Oncología en Ciudad de La Habana, que contemple la priorización de los requerimientos asistenciales en las áreas quirúrgicas y de quimioterapia ambulatoria, haciendo énfasis en las particularidades de las localizaciones de cáncer más frecuentes.
46 downloads
Showing
itens per page
Page
of 1
Next
Statistics of
Send result
Sem resultados
No documents were found for your search
Glossary and search help
You can enrich your search in a very simple way. Use the search indexes combined with the connectors (AND or OR) and specify more your search.
For example, if you want to search for articles about
cases of dengue in Brasil in 2015, use:ti:dengue and publication_year:2015 and aff_country:Brasil
See below the complete list of search indexes that can be used:
Index code | Element |
---|---|
ti | article title |
au | author |
kw | article keywords |
subject | subject (title words, abstract and keywords) |
ab | abstract |
ta | journal short title (e.g. Cad. Saúde Pública) |
journal_title | journal full title (e.g. Cadernos de Saúde Pública) |
la | publication language code (e.g. pt - Portuguese, es - Spanish) |
type | document type |
pid | publication identifier |
publication_year | publication year of publication |
sponsor | sponsor |
aff_country | country code of the author's affiliation |
aff_institution | author affiliation institution |
volume | article volume |
issue | article issue |
elocation | elocation |
doi | DOI number |
issn | journal ISSN |
in | SciELO colection code (e.g. scl - Brasil, col - Colômbia) |
use_license | article usage license code |