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Abstract The first case of cerebral venous thrombosis, described in the past century, was identified in obstetric patients in 1825. The clinical manifestations represent a real diagnostic challenge due to the few recorded cases, the wide variety of possible clinical symptoms, and the diversity of medical conditions that cause it. In the past century, the etiology was mainly associated with septic processes; however, due to the widespread use of antibiotics, this cause has been considerably reduced. In the context of the puerperium, several conditions make this group of patients more vulnerable, such as dehydration, hypercoagulable state, iron deficiency, puerperal sepsis, and preeclampsia, the latter is particularly known for an endothelial lesion with different degrees of associated severity, according to the clinical phenotype present. This review aims to highlight the most relevant aspects of cerebral thrombosis in the context of a puerperal patient. It will also present clinical cases reports treated successfully in this health unit.

https://doi.org/10.24875/hgmx.23000054

First record of the bluntnose sixgill shark Hexanchus griseus (Bonnaterre, 1788) in the Guatemalan Caribbean Sea
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Sánchez-Jiménez, Julio

; Santana-Morales, Omar

; Ayala-Donado, Josué

; Rosales-Melgar, María de los

; Areano-Barillas, Elisa M.

; González-Jaramillo, Mónica

; Pérez-Jiménez, Juan Carlos

Latin american journal of aquatic research

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may 2024, Volume 52 N. 2 Pages 307 - 311

Abstract: En | Text: En | PDF: En

ABSTRACT The Guatemalan Caribbean has a deepwater fishing area close to the shore around the Cayman Trench. This study reports the first record of the bluntnose sixgill shark (Hexanchus griseus) from this fishing area. Fishery-independent surveys using longlines at ~430-465 m depth, ~11 km northeast of El Quetzalito fishing village, were conducted in 2022 and 2023. Two bluntnose sixgill sharks were captured during these surveys. The sharks were females with total lengths of 300 and 310 cm, with morphological characteristics consistent with this species. These are the first confirmed records of bluntnose sixgill sharks in the western Caribbean Sea. Expanding coastal fisheries to deeper waters presents an emerging threat to deep-sea chondrichthyans in the region. Therefore, periodic fisheries monitoring is needed to estimate their vulnerability to fishing pressure.

https://doi.org/10.3856/vol52-issue2-fulltext-3098

First record of the kitefin shark, Dalatias licha (Bonnaterre, 1788) from the Guatemalan Caribbean Sea
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Sánchez-Jiménez, Julio

; Ayala-Donado, Josué

; Rosales Melgar, María de los Ángeles

; Areano-Barillas, Elisa M.

; Kasana, Devanshi

; González-Jaramillo, Mónica

; Pérez-Jiménez, Juan Carlos

Latin american journal of aquatic research

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may 2024, Volume 52 N. 2 Pages 318 - 322

Abstract: En | Text: En | PDF: En

ABSTRACT Deepwater fishing operations occur close to the shore of the Guatemalan Caribbean. In a study to characterize the deepwater species present in the fishing area, the incidental catch of a kitefin shark, Dalatias licha, was recorded at a depth of ~284-334 m, ca. 11 km northeast of El Quetzalito fishing village. The adult female with a total length of 1420 mm had morphological characteristics consistent with D. licha, which was confirmed by molecular methods. First record of D. licha in the western Caribbean region, a species cataloged at risk by the IUCN red list. With this record, the number of shark species known in the Guatemalan Caribbean increases to 25.

https://doi.org/10.3856/vol52-issue2-fulltext-3132

Visual assessment of leaf area index in coffee (Coffea arabica L.) fields Coffea L. L
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Castro-Pacheco, Sergio A.

; González-Lutz, María I.

; Araya-Alfaro, José M.

; Vargas-Chinchilla, Mariano

; Gutiérrez-Soto, Marco V.

Revista Brasileira de Engenharia Agrícola e Ambiental

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mar 2024, Volume 28 N. 3 elocation e274355

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

ABSTRACT The application of leaf area index (LAI) in coffee crop management depends on the availability of methodologies for proper estimation. The objective of this study was to develop a methodology for the visual assessment of LAI in coffee fields and to establish a protocol for training, evaluation, and feedback for evaluators. Four rounds of LAI measurements were conducted using visual estimates, two instruments (LAI 2200-C and AccuPAR LP-80), and defoliation of coffee hedgerows in Poás, Costa Rica. In each round, five workers visually estimated the LAI values on two occasions separated by 15 days, and feedback reinforcement was provided to each worker at the end of each round. Visual assessments showed high repeatability and reproducibility and the estimates were adjusted to the linear regression model in most cases. Evaluators improved their capacity to visually assess the LAI throughout the rounds, as the value of R2increased consistently for most workers, with values as high as 0.87. Instrumentation evaluation of LAI produced R2values of 0.5-0.6, with significant underestimation bias. The performance of the different methods is discussed in the context of widely spaced hedgerows. The proposed visual methodology constitutes a statistically sound, rapid, simple, and reliable method for determining the LAI of coffee fields to aid in decision-making for crop management. estimation training evaluators 2200C C 2200 LP80, LP80 LP 80 , LP-80) Poás Rica round 1 days cases Rincreased R increased 087 0 87 0.87 Rvalues 0.50.6, 0506 0.5 0.6, 5 6 0.5-0.6 bias sound rapid simple decisionmaking decision making 220 LP8 8 LP-80 08 0.8 50 0.50.6 050 05 0. 06 0.6 0.5-0. 22 LP-8 0.50. 0.5-0 2 LP- 0.50 0.5-

RESUMO A aplicação do índice de área foliar (IAF) na gestão da cultura do cafeeiro depende da disponibilidade de metodologias para sua estimativa correta. É proposta aqui uma metodologia para a avaliação visual do IAF em plantas de café, por tanto se estabelece um protocolo para o treinamento dos avaliadores. Foram feitas quatro rodadas de medições do IAF utilizando estimativas visuais, dois instrumentos (LAI 2200-C e AccuPAR LP-80), e desfolhações de sebes de café na Costa Rica. A cada rodada, cinco trabalhadores estimaram visualmente os valores do IAF em duas ocasiões e separados por 15 dias. Ao final de cada rodada, foi dada uma retroalimentação a cada trabalhador. A avaliação visual mostrou alta repetibilidade e reprodutibilidade, e as estimativas foram ajustadas para o modelo de regressão linear na maioria dos casos. Os avaliadores melhoraram sua capacidade de avaliar visualmente o IAF ao longo das rodadas, e o valor de R2 aumentou consistentemente para a maioria dos trabalhadores, com valores tão altos quanto 0,87. A avaliação do IAF por instrumentos produziu valores de R2 de 0,5-0,6, com significativa tendência de subestimação, e não se ajustou ao modelo de regressão linear. O desempenho dos diferentes métodos é discutido no contexto de coberturas com amplo espaço. A metodologia visual proposta constitui uma determinação sólida, rápida, simples e confiável do IAF na lavoura do café e considera-se uma ajuda na tomada de decisões para a gestão da safra. (IAF correta visuais LAI 2200C C 2200 LP80, LP80 LP 80 , LP-80) Rica rodada 1 dias trabalhador reprodutibilidade casos R 087 0 87 0,87 0,50,6, 0506 0,5 0,6, 5 6 0,5-0,6 subestimação espaço sólida rápida considerase considera safra 220 LP8 8 LP-80 08 0,8 50 0,50,6 050 05 0, 06 0,6 0,5-0, 22 LP-8 0,50, 0,5-0 2 LP- 0,50 0,5-

https://doi.org/10.1590/1807-1929/agriambi.v28n3e274355

Fungal enemies isolated from the root and rhizosphere of guava against the root-knot nematode rootknot knot
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Silva-Riveros, Deisy Lorena

; Parra-González, Sergio David

; Mogollón-Ortiz, Ángela María

Bragantia

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2024, Volume 83 elocation e20230263

Abstract: En | Text: En | PDF: En

ABSTRACT The fungal microbiota associated with the roots and rhizosphere of plants represents a significant source of biocontrol agents against the root-knot nematode Meloidogyne spp. While some fungal genera have been studied extensively, others require more attention in terms of their identity and mechanisms of action against plant parasitic nematodes. Thus, the aim of this research was to demonstrate the in vitro and in vivo biocontrol potential of fungi isolated from the root and rhizosphere of guava plants against the root-knot nematode Meloidogyne incognita. We isolated four fungi (C5, C6, C7, and C10) from the root and rhizosphere of guava plants using the serial dilution method. These fungi were purified on potato dextrose agar and evaluated in vitro to assess their ability to parasitize M. incognita eggs and juveniles. Subsequently, the fungi were assessed for M. incognita control under nursery conditions in guava plants. The identity of the fungi with parasitic capacity and biocontrol potential was confirmed by amplifying and sequencing the ITS region, followed by Bayesian inference analysis. Results showed that the fungi corresponded to Talaromyces sayulitensis (C5), Myrothecium sp. (C6), Penicillium shearii (C7), and Beauveria bassiana (C10). Parasitism of M. incognita eggs was confirmed for all fungi, parasitism of juveniles occurred with T. sayulitensis (C5) and B. bassiana (C10). In guava seedlings treated with fungal isolates, a significant reduction in the number of eggs, juveniles, and nodules per gram of root was achieved. The biocontrol potential against M. incognita in guava seedlings was confirmed for different fungi associated with the root rhizosphere. rootknot knot spp extensively nematodes Thus C5, C5 C (C5 C6 C7 C10 method M Subsequently region analysis , sp (C6) (C7) C10. . (C10) T B isolates achieved (C C1 (C6 (C7 (C10 (C1

https://doi.org/10.1590/1678-4499.20230263

Experiencia de Cuidadores y Facilitadores sobre la Implementación Online de GenerationPMTO en Contexto de Pandemia
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Grau Rengifo, M. Olaya

; Pardo Galarce, Débora

; Álamo Anich, Nicolle

; González Suitt, Karla

; Fernández Sanz, Sofía

; Cárdenas Sánchez, M. Elvira

; Banderas Montalva, José Miguel

; Cantizano Rioseco, Luz

; Ruiz Leiva, Constanza

; Correa Molina, María Luisa

; Perry Mitchell, Raúl

Psykhe (Santiago)

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2024, Volume 33 N. 2

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

Abstract: This research seeks to know the experience of participants -15 caregivers of children between 4 and 12 years old from two schools with a high vulnerability index in Santiago de Chile and 4 facilitators - in the GenerationPMTO program adapted to a remote modality, in the context of the COVID-19 health crisis. A descriptive, exploratory, qualitative study was carried out. Semi-structured interviews with 15 caregivers from both schools participating in the program; one focus group with 4 facilitators who implemented the online program; and a documentary review of the journals registered by the facilitators after each session were conducted. The information collected was analyzed qualitatively through the open coding procedures of Grounded Theory. After that, the perspectives of both groups were gathered through an integrated analysis. From the experience of participants, the online adaptation of the program was successful since the facilitators were able to develop the contents and strategies of the intervention in virtual mode, and the families were able to participate and learn them from their homes. This was compatible with physical distancing (given the COVID-19 pandemic) and allowed caregivers' participation in the program to be compatible with other life activities. Among challenges, strengthening group participation and cohesion were highlighted, as well as overcoming barriers related to unstable internet connection and/or inappropriate home conditions to participate. These results show a successful adaptation of the program from the perspective of its participants, providing insights that contribute to improve the adaptation of this and other programs to virtual modality.

Resumen: Esta investigación buscó conocer la experiencia de los participantes -15 cuidadores de niños entre 4 y 12 años de dos escuelas con alto índice de vulnerabilidad en Santiago de Chile y 4 facilitadores - del programa GenerationPMTO en su adaptación a modalidad remota, en contexto de crisis sanitaria causada por COVID-19. Se realizó un estudio cualitativo exploratorio descriptivo, en el cual se realizaron entrevistas semiestructuradas a 15 cuidadores de ambas escuelas participantes del programa, un grupo focal con 4 facilitadoras que implementaron el programa de forma online y una revisión documental de las bitácoras completadas por las facilitadoras luego de cada sesión. La información recolectada fue analizada cualitativamente a través de los procedimientos de codificación abierta de la teoría fundamentada, para luego reunir las perspectivas de ambos grupos en un análisis integrado. Desde la experiencia de los participantes, la adaptación del programa a formato online resultó exitosa, ya que las facilitadoras lograron desarrollar los contenidos y estrategias de la intervención en modalidad virtual y los cuidadores pudieron participar y aprender desde sus casas, siendo esto compatible con el distanciamiento físico (por COVID-19) y con otras actividades de la vida de los cuidadores. Se destacan como desafíos potenciar la participación y cohesión grupal y superar barreras relacionadas con la conexión a Internet inestable y/o lugar físico poco adecuado en algunos hogares para participar. Estos resultados muestran una exitosa adaptación del programa desde la perspectiva de sus participantes, aportando aprendizajes que permitirán mejorar la adaptación de este y otros programas a modalidad virtual.

https://doi.org/10.7764/psykhe.2021.46295

Manejo interdisciplinario de la obesidad y el sobrepeso en rehabilitación cardiaca: revisión de la Sociedad Mexicana para el Cuidado del Corazón
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Lara-Vargas, Jorge A.

; Pérez-Reyes, Angélica A.

; Núñez-Urquiza, Juan P.

; Navarrete de la O, Dulce M.

; Ilarraza-Lomelí, Hermes

; Leyva-Valadez, Eduardo A.

; González-Rentería, María E.

; Romero-Rendón, Minerva

; Ponce-de-León-Espíndola, Marcos

; Maldonado-Ramírez, Martha C.

; Rubio-Blancas, Aquiles

Archivos de cardiología de México

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dec 2023, Volume 93 N. 4 Pages 464 - 475

Abstract: Es En | Text: Es En | PDF: Es | PDF: En

Resumen Antecedentes: La obesidad es un trastorno multifactorial caracterizado por un aumento en la adiposidad corporal, de amplia prevalencia en nuestro país, a cualquier edad y ligada a grandes consecuencias adversas, incluyendo el desarrollo de cardiopatías. Los programas de rehabilitación cardiaca (RC) son intervenciones interdisciplinarias encaminadas no solo a restaurar la funcionalidad perdida de los pacientes que han sufrido un desenlace cardiovascular, sino también a corregir aquellos factores de riesgo que lo propiciaron y que interfieren en los resultados adaptativos del mismo. La obesidad contribuye a perpetuar el riesgo de cardiopatía y suele ser resistente a las modificaciones del estilo de vida de manera convencional. Objetivo: Establecer pautas en el reconocimiento de la obesidad con directrices de atención al paciente con cardiopatía dentro de los programas de RC y su abordaje interdisciplinario. Método: A través de una extensiva revisión bibliográfica y después de una discusión interdisciplinaria, se elaboró el presente documento para fijar una postura sobre el abordaje de la obesidad en el contexto de los programas de RC en pacientes con cardiopatía. Resultados y conclusiones: Nuestra Sociedad reconoce el abordaje interdisciplinario de los pacientes con obesidad y cardiopatía en su prevención primaria y secundaria, insta a la precisión en su diagnóstico y valoración, y recomienda que su eje primario debe estar basado en primera instancia en las modificaciones del estilo de vida (entrenamiento físico, atención nutricional e intervención psicoemocional), en tanto que la terapia farmacológica y la cirugía bariátrica pudieran ser coadyuvantes en la optimización de los resultados en pacientes selectos.

Abstract Background: Obesity is a multifactorial disorder characterized by increased body adiposity with a wide prevalence in our country, at any age, and linked to major adverse consequences, including the development of heart disease. Cardiac rehabilitation (CR) programs are interdisciplinary interventions aimed not only at restoring the lost functionality of patients who have suffered a cardiovascular outcome, but also at correcting those risk factors that led to it and that interfere with its adaptive results. Obesity contributes to perpetuating heart disease risk and is often resistant to conventional lifestyle modifications. Objective: Establish guidelines in the recognition of obesity with care guidelines for patients with heart disease within CR programs and their interdisciplinary approach. Method: Through an extensive bibliographical review and after an interdisciplinary discussion, this document was prepared to establish a position on the approach to obesity in the context of CR programs in patients with heart disease. Results and conclusions: Our Society recognizes the interdisciplinary approach of our patients with obesity and heart disease in its primary and secondary prevention, urges precision in its diagnosis and assessment, recommends that its primary axis must be based in the first instance on lifestyle modifications (physical training, nutritional care and psycho-emotional intervention), while pharmacological therapy and bariatric surgery could be coadjuvants in optimizing the results in selected patients.

https://doi.org/10.24875/acm.22000288

Third National Registry of Cardiac Rehabilitation Programs in Mexico (RENAPREC III-2022)
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Lara-Vargas, Jorge A.

; Ilarraza-Lomelí, Hermes

; García-Saldivia, Marianna

; Pineda-García, Alfredo D.

; Leyva-Valadez, Eduardo A.

; Justiniano-Cordero, Samuel

; Sahagún-Olmos, Roberto

; Zavala-Ramírez, Juana

; Cassaigne-Guasco, María E.

; Sánchez-Limón, Edgar-F

; Castañeda-López, Javier

; Cerón-Enríquez, Norma

; Ku-González, Andrés

; Arteaga-Martínez, Rodolfo

; Hinojosa-López, Tania

; Vergara-Guzmán, Jéssica

; Pérez-Vázquez, Daniel I.

; Gasca-Zamudio, Pedro D.

; Aranda-Ayala, Zulema L.

; Vacío-Reyes, Martha E.

; Reza-Orozco, Marco

; Alcocer-Gamboa, Miguel A.

; Hernández-González, Pedro A.

; Pérez-Reyes, Angélica A.

; Núñez-Urquiza, Juan P.

; Alonso-Sánchez, Jesús

; Franco-Valles, Sarahí

; Romo-Escamilla, Ricardo E.

; Nuriulú-Escobar, Patricia

; Serna-Santamaría, Iván

; Avilés-González, Jorge

; Salgado-Solorio, María C.

; Muñoz-Gutiérrez, Luz M.

; Mendoza-Díaz, Pedro M.

; Ávila-Estrada, Ángel

; Morales-Medina, Carlos

; Lara-Vázquez, Eduardo

; Rodríguez-Herrera, Paulina

; Galván-López, María

; Segoviano-Mendoza, Georgina

; De-la-Torre-Cruz, Fabiola

; Jiménez-Campos, Cecilia

; Ramírez-Meléndez, Alejandra

; Almaraz-Ríos, Alejandro

; González-Bonilla, Mezthly

; Rojano-Castillo, Jessica

; Rius-Suarez, María D.

Archivos de cardiología de México

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dec 2023, Volume 93 N. 4 Pages 405 - 416

Abstract: Es En | Text: Es En | PDF: Es | PDF: En

resumen está disponible en el texto completo

Abstract Introduction: In Mexico, cardiac rehabilitation (CR) as an interdisciplinary intervention with therapeutic impact in patients with heart disease is growing. There is the need to know actual conditions of CR in our country. Objectives: The objective of this National Registry is to follow-up those existing and new CR units in Mexico through the comparison between the two previous registries, RENAPREC-2009 and RENAPREC II-2015 studies. This is a descriptive study focused on diverse CR activities such as assistance training, and certification of health professionals, barriers, reference, population attended, interdisciplinarity, permanence over time, growth prospects, regulations, post-pandemic condition, integrative characteristics, and scientific research. Results: Data were collected from 45 CR centers in the 32 states, 75.5% are private practice units, 67% are new, 33% were part of RENAPREC II-2015, and 17 have continued since 2009. With a better distribution of CR units along the territory, the median reference of candidates for CR programs is 9% with a significant reduction into tiempo of enrollment to Phase II admission (19 ± 11 days). Regarding to previous registries, the coverance of Phases I, II, and III is 71%, 100%, and 93%, respectively; and a coverance increases in evaluation, risk stratification, and prescription, more comprehensive attendance and prevention strategies. Conclusions: CR in Mexico has grown in the past 7 years. Even there is still low reference and heterogeneity in specific processes, there are strengths such as interdisciplinarity, scientific professionalization of specialists, national diversification, and an official society that are consolidated over time.

https://doi.org/10.24875/acm.22000235

Cobertura algal en dos sitios del Parque Nacional de Guanahacabibes, plataforma suroccidental de Cuba
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Alfonso, Yusimí

; González-Sánchez, Patricia-M.

; Caballero, Hansel

; Chevalier, Pedro-Pablo

; Díaz-Larrea, Jhoana

; Cabrera, Ruben

Revista de Biología Tropical

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dec 2023, Volume 71 N. 1 elocation e53057

Abstract: Es En | Text: Es En | PDF: Es | PDF: En

Resumen Introducción: Las comunidades de macroalgas marinas del Parque Nacional Guanahacabibes no han sido estudiadas desde el punto de vista cuantitativo, a pesar de la influencia que la vegetación submarina tiene sobre la estructura y el funcionamiento de los ecosistemas costeros, componente que hasta ahora ha sido subestimado en la región. Objetivo: Evaluar la variación temporal y espacial de los géneros de macroalgas en dos sitios de María La Gorda, sur del Parque Nacional de Guanahacabibes, y evaluar la salud del arrecife de acuerdo con la cobertura de los diferentes morfo-tipos de macroalgas predominantes. Metodología: El muestreo fue cuatrimestral entre febrero 2014 y marzo 2017 en Yemayá y Laberinto, mediante buceo autónomo a una profundidad de 10 m. La cobertura algal fue estimada siguiendo la metodología AGRRA. Se usaron ocho transectos de 20 m por sitio de muestreo de acuerdo con las condiciones del arrecife y la forma del fondo. Cada cinco metros se colocó un cuadrante de 25 x 25 cm. Se calculó el porcentaje de cobertura que aporta cada género y de los grupos morfofuncionales a la cobertura total. Resultados: Los géneros dominantes durante el periodo de estudio fueron: Dictyota, Lobophora y Halimeda. Las algas carnosas y calcáreas mostraron mayor cubrimiento en Laberinto (carnosas= 57.8 ±15.6; calcáreas = 8.3 ± 6.8) que en Yemayá, (carnosas = 47.3 ± 23.1; calcáreas = 8.5 ± 9.3). Las formas costrosas son más abundantes en Yemayá (17.1 ± 15.1) que en Laberinto (7.7 ± 10). El índice de las carnosas fue superior en Laberinto (225.7 ± 110.2). Conclusión: La disminución en los niveles de cobertura de algas costrosas y la dominancia de formas carnosas como Dictyota y Lobophora en la zona de estudio, evidencian el deterioro en ambos sitios, a pesar de las políticas de conservación de parques nacionales.

Abstract Introduction: The macroalgal communities of the Guanahacabibes National Park have been poorly studied from the quantitative point of view, despite the influence that underwater vegetation has on the structure and functioning of coastal ecosystems, a component that until now has been underestimated in the Cuba region. Objetive: To evaluate the temporal and spatial variation of the macroalgal genera in two sites of María La Gorda, south of the Guanahacabibes National Park, and evaluate the reef health according to the coverage of the different predominant macroalgal morphotypes. Methodology: Sampling took place quarterly between February 2014 and March 2017, in Laberinto and Yemayá by SCUBA diving at a depth of 10 m. The algal coverage was estimated following the AGRRA methodology. Eight 20 m transects per sampling site were used according to reef conditions and bottom shape. Every five meters a 25 x 25 cm square was placed. The coverage (%) contributed per genus and morpho-functional group to the total coverage found was calculated. Results: The dominant genera during the study period were: Dictyota, Lobophora and Halimeda. Fleshy and calcareous algae showed greater coverage in Laberinto (fleshy= 57.8 ± 15.6; calcareous = 8.3 ± 6.8) than in Yemayá (fleshy = 47.3 ± 23.1; calcareous = 8.5 ± 9.3). Crustose algae were more abundant in Yemayá (17.1 ± 15.1) than in Laberinto (7.7 ± 10). The fleshy index was higher in Laberinto (225.7 ± 110.2). Conclusion: The decrease in the levels of crustose algal cover, as well as the dominance of fleshy forms Dictyota and Lobophora in the study area, shows the deterioration in both sites, despite the conservation policies of national parks.

https://doi.org/10.15517/rev.biol.trop..v71i1.53057

10.

Evaluación preclínica y clínica de SOBERANA® 01. Candidato vacunal contra la COVID-19
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Climent Ruiz, Yanet

; Santana Mederos, Darielys

; PérezRodríguez, Sonia

; Rodríguez González, Meiby de la Caridad

; García Rivera, Dagmar

; Sánchez Ramírez, Belinda

; Valdés Balbín, Yury

; Vérez Bencomo, Vicente

; Rodríguez Noda, Laura M.

; Pérez Nicado, Rocmira

; Ochoa Azze, Rolando

; Boggiano Ayo, Tammy

; Valenzuela Silva, Carmen María

; González Rodríguez, Humberto

; Ramírez González, Ubel J.

; Paredes Moreno, Beatriz

; García Rivera, Daniel

; Labrada Regalado, Claudia

; Hernández García, Tays

; Noa Romero, Enrique

; Díaz Hernández, Marianniz

; OrosaVázquez, Ivette

; BergadoBáez, Gretchen

; Pi Estopiñán, Franciscary

; Hernández Salazar, Tamara

; Fariñas Medina, Mildrey

; Enriquez Puertas, Juliet María

; González Sosa, Nibaldo Luis

; González Delgado, Carlos A.

; Rubino Moreno, Jorman

; Díaz Machado, Alina

; González Freire, Yunior

; Esmoris Mena, Yudisleidy

; Rosales Gil, Lilia Beatríz

; Chappi Estévez, Yanet

; Amoroto Roig, Mayté

; Martínez Pérez, Marisel

; Ontiveiro Pino, Ivis

; Landys Chovel Cuervo, Mario

; Garrido Arteaga, Raine

; Cardoso San Jorge, Félix

; González Mugica Romero, Raúl

; Fernández Castillo, Sonsire

; Ojito Magaz, Eduardo

; Chiodo, Fabrizio

; Paquet, Francoise

; Fang, Cheng

; Guang-Wu, Chen

Anales de la Academia de Ciencias de Cuba

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dec 2023, Volume 13 N. 4 elocation e1512

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

ABSTRACT Introduction: SOBERANA® 01 was developed at the Finlay Vaccine Institute to combat the epidemic caused by the SARS-CoV-2 virus. This candidate is based on the Receptor Binding Domain (RBD) in dimeric form combined with purified vesicles from outer membrane of serogroup B meningococcus as immunopotentiator of the immune response adsorbed on aluminum hydroxide. Methods: The antigen was designed with the peculiarity of having a free cysteine at position 538, which allows the formation of RBD dimers. In preclinical studies it was evaluated the immunogenicity of the dimer combined with the outer membrane vesicles and they were performed toxicological studies. In addition, it was designed a Phase I clinical study in subjects from 19 to 59 years old. Results: The antigenic presentation in the form of dimer combined with the vesicles proved to be safe and immunogenic in animal models, observing a significant increase in the immune response when compared to the monomeric form. During the Phase I clinical evaluation, which included apparently healthy subjects between the ages of 19 and 59, it was demonstrated that SOBERANA® 01 lead to a significant increase in the neutralizing antibody response compared to the use of aluminum hydroxide as the sole adjuvant. After the third dose, 100% of the subjects seroconverted to the group immunized with SOBERANA® 01. Conclusions: It was demonstrated the immunogenicity and neutralizing capacity of the antibodies induced by SOBERANA® 01. The analysis of the sera of the vaccinated persons demonstrated that the formulation containing the OMVs causes a more potent neutralizing effect against several RBD mutants present in VOCs, including the RBD triple mutants of the beta variant.

RESUMEN Introducción: SOBERANA® 01 se desarrolló en el Instituto Finlay de Vacunas para el enfrentamiento a la epidemia causada por el virus SARS-CoV-2. Este candidato se basa en el dominio de unión al receptor en forma dimérica, combinado con vesículas purificadas de membrana externa de meningococo del serogrupo B como inmunopotenciador de la respuesta inmune adsorbidos en hidróxido de aluminio. Métodos: Se diseñó el antígeno con la peculiaridad de tener una cisteína libre en la posición 538, que permite la formación de dímeros del dominio de unión al receptor. En estudios preclínicos se evaluó la inmunogenicidad del dímero combinado con las vesículas de membrana externa y se realizaron estudios toxicológicos. Además, se diseñó un estudio clínico fase I en sujetos de 19 años a 59 años. Resultados: La presentación antigénica en forma de dímero combinado con las vesículas demostró ser segura e inmunogénica en modelos animales observando un incremento significativo de la respuesta inmune cuando se compara con la forma monomérica. Durante la evaluación clínica fase I, que incluyeron sujetos aparentemente sanos de entre 19 años y 59 años de edad, se demostró que SOBERANA® 01 conduce a un aumento importante en la respuesta de anticuerpos neutralizantes en comparación con el uso de hidróxido de aluminio como único adyuvante. Después de la tercera dosis, el 100 % de los sujetos seroconvirtieron en el grupo inmunizado con SOBERANA® 01. Conclusiones: Se demostró la inmunogenicidad y la capacidad neutralizante de los anticuerpos inducidos por SOBERANA® 01. El análisis de los sueros de las personas vacunadas demostró que la formulación que contiene las vesículas de membrana externa provoca un efecto neutralizante más potente contra varios mutantes del dominio de unión al receptor presentes en los COV, incluidos los mutantes triples del dominio de unión al receptor de la variante Beta.

11.

Escala “Pediatric Index Mortality 3” (PIM3) como predictor de mortalidad en unidades de cuidado intensivo pediátrico ubicadas a gran altitud
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López-Barón, Eliana

; Vasquez Hoyos, Pablo

; Martinez-Solarte, Mario

; Godoy, Javier

; Maya, Luis Carlos

; Ramírez, Ivan Perdomo

; Mejía, Luz Marina

; Godoy, Carol

; Pardo, Rosalba

; Roa, Juan David

; Mazzillo, Liliana

; González, Otto

; Fernández-Sarmiento, Jaime

; Izquierdo Borrero, Ledys María

; Duitama Vergara, Lorena

; Reyes, Martha

Andes pediatrica

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aug 2023, Volume 94 N. 4 Pages 436 - 443

Abstract: Es En | Text: Es En | PDF: Es | PDF: En

Resumen: El Pediatric Index of Mortality 3 (PIM3) es una escala que estima el riesgo de mortalidad en niños ingresados a Unidad de Cuidado Intensivo Pediátrico (UCIP) en la primera hora del ingreso. Objetivo: validar la escala PIM3 en población pediátrica que ingresa a UCIP en alturas sobre los 2.500 metros sobre el nivel del mar (m.s.n.m.), y evaluar si el lactato y el índice Saturación de Oxígeno/Fracción inspirada de oxígeno (SpO2/FiO2) mejoran su capacidad de predicción de mortalidad. Pacientes y Método: Estudio prospectivo multicéntrico realizado en diez UCIP de Colombia entre noviembre de 2016 y junio de 2017. Se recolectaron variables para cálculo del PIM3, lactato sérico y el índice SpO2/FiO2. Se validó su capacidad de discriminación con el área bajo la curva ROC y la calibración mediante la prueba de bondad de ajuste de Hosmer Lemeshow. Resultados: Se incluyeron 2.803 registros de admisiones, con una mortalidad global de 4,8%, y razón estandarizada de mortalidad de 1,1 (IC95%; 1,00-1,3). El PIM3 mostró una baja calibración (p < 0,001) y una adecuada discriminación para la población aplicada (ROC 0,84; IC95% 0,83-0,86). La adición de lactato sérico y SpO2/ FiO2 permitieron una buena calibración (p = 0,75), y mantuvo una alta discriminación de mortalidad (ROC 0,86; IC95% 0,84-0,87). Conclusiones: El comportamiento de la escala PIM3 tiene adecuada discriminación, pero una baja calibración en niños admitidos a UCIP sobre los 2500 m.s.n.m.. Las variables lactato y SpO2/FiO2 mejoraron su habilidad predictiva.

Abstract: The Pediatric Index of Mortality 3 (PIM3) is a scale that estimates the risk of mortality in children admitted to the Pediatric Intensive Care Unit (PICU) within the first hour of admission. Objective: to validate the PIM3 scale in pediatric population admitted to PICU at altitudes over 2,500 meters above sea level (m.a.s.l.), and to evaluate whether lactate and the oxygen saturation/fraction of inspired oxygen (SpO2/FiO2) index improve its ability to predict mortality. Patients and Method: A prospective multicenter study was carried out in 10 PICUs in Colombia between November 2016 and June 2017. Variables were collected for the calculation of PIM3, serum lactate, and SpO2/FiO2 index. Their discrimination capacity was validated with the area under the ROC curve and calibration using the Hosmer Lemeshow goodness-of-fit test. Results: 2,803 admissions were included, with an overall mortality of 4.8% and a standardized mortality ratio of 1.1 (95%CI 1.00-1.3). PIM3 showed low calibration (p < 0.001) and adequate discrimination for the studied population (ROC 0.84; 95%CI 0.83-0.86). The addition of serum lactate and SpO2/FiO2 allowed a good calibration (p = 0.75) and maintained a high discrimination of mortality (ROC 0.86; 95%CI 0.84-0.87). Conclusions: The performance of the PIM3 scale has adequate discrimination, but low calibration in children admitted to PICU at above 2500 m. a. s. l. Lactate and SpO2/FiO2 variables improved its predictive ability.

https://doi.org/10.32641/andespediatr.v94i4.4528

12.

Fístula aortoentérica y su manejo multidisciplinar
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Calvo-García, Haydée

; Herrera-Kok, Johnn H.

; Álvarez-Martínez, Antonio

; Maqueda-Ara, Silvia

; Ortega-Martín, José M.

; Elosua-González, Tomás

; Diago-Santamaría, María V.

Cirugía y cirujanos

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aug 2023, Volume 91 N. 4 Pages 571 - 575

Abstract: Es En | Text: Es En | PDF: Es | PDF: En

Resumen La fístula aortoentérica es una patología poco frecuente, pero de riesgo vital, asociada a alta morbimortalidad. Puede ser primaria (aneurisma, neoplasia, radioterapia, infección) o secundaria a prótesis vascular. El diagnóstico precoz y el tratamiento quirúrgico agresivo son los pilares fundamentales para lograr buenos resultados en estos pacientes. El objetivo de este trabajo es destacar la importancia del diagnóstico precoz de la fístula aortoentérica y su manejo multidisciplinar, mediante la presentación de un caso clínico.

Abstract Aortoenteric fistula is an uncommun life-threatening condition which remains associated with significant morbidity and mortality. It can be primary (aneurysm, neoplasms, radiation therapy, infection) or secondary to vascular prosthesis. Early diagnosis and aggressive surgical treatment are very important to achieve optimal outcomes in these patients. The aim of this article is to highlight the importance of early diagnosis and multidisciplinary approach of aortoenteric fistula through the presentation of a clinical case.

https://doi.org/10.24875/ciru.21000702

13.

Microascus gracilis y otomicosis
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Sante Fernández, Laura

; Capón González, Patricia

; Domínguez, Javier Alba

; González, María José Gude

Revista chilena de infectología

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jun 2023, Volume 40 N. 3 Pages 313 - 314

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

Abstract Microascus spp, a teleomorph of Scopulariopsis, is a saprophytic fungus normally found in soil, food, vegetables, and even indoors. Considered an environmental pollutant, it is characterized by its intrinsic resistance to available antifungals. There are few references to infections by Microascus gracilis, associating it as a cause of eumycetoma or disseminated disease in lung transplant recipients. We present a case of otomycosis caused by M. gracilis, to consider the search for fungi in ear cultures and highlight the pathogenic and colonizing power of this agent.

Resumen Microascus spp, teleomorfo de Scopulariopsis, es un hongo saprofito encontrado normalmente en suelo, alimentos, vegetales e incluso en ambientes interiores. Considerado un contaminante ambiental, se caracteriza por la resistencia intrínseca a los antifúngicos disponibles. Existen escasas referencias de infecciones por Microascus gracilis, asociándose como causa de eumicetoma o enfermedad diseminada en pacientes sometidos a trasplante pulmonar. Presentamos un caso de otomicosis por M. gracilis con el fin de considerar la búsqueda de hongos en los cultivos óticos y poner de relevancia el poder patógeno y colonizador de este agente.

https://doi.org/10.4067/s0716-10182023000300313

14.

Eventos adversos sistémicos post-vacuna BCG. Serie de casos pediátricos
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González, Norma Edith

; Pawluk, Victor Oscar

; Marin, Edith Macha

; Urteneche, María Inés

; Cassanelli, Martín

Revista chilena de infectología

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feb 2023, Volume 40 N. 1 Pages 28 - 34

Abstract: Es En | Text: Es En | PDF: Es | PDF: En

Resumen La vacuna BCG es clave para el control de la tuberculosis. En ocasiones se observan eventos adversos sistémicos causados por Mycobacterium bovis BCG; usualmente asociados a inmunodeficiencia. Describimos seis casos clínicos de niños vacunados con BCG al nacer, con complicaciones sistémicas post-vacunación. Método: Revisión de historias clínicas de pacientes con infección por M. bovis BCG atendidos en un hospital pediátrico, entre 2010 y 2019. Resultados: De 400 casos confirmados de infecciones por complejo Mycobacterium tuberculosis; ocho fueron identificados como M. bovis BCG; seis casos correspondieron a eventos adversos sistémicos post-vacuna BCG: dos con lesiones cutáneas a distancia, dos osteomielitis y dos infecciones generalizadas. En cinco de los seis pacientes se detectó una alteración de la respuesta inmune. Un paciente falleció por falla multiorgánica, uno se derivó y cuatro completaron 12 meses de tratamiento: dos meses de isoniacida, rifampicina, etambutol, y moxifloxacina, y 10 meses de isoniacida y rifampicina. Tuvieron buena tolerancia a los medicamentos, sin recaída a los dos años. Conclusión: La infección grave por M. bovis BCG es una rara complicación sistémica de la vacunación. Es razonable buscar defectos inmunológicos en los niños que desarrollan este tipo de eventos adversos.

Abstract The BCG vaccine is key to tuberculosis control. Systemic adverse events caused by Mycobacterium bovis BCG are occasionally observed; usually associated with immunodeficiency. In this report we describe six cases of children vaccinated with BCG at birth, with post-vaccination systemic complications. Method: retrospective review of medical records of patients with M. bovis BCG infection treated in a pediatric hospital between 2010 and 2019. Results: Of 400 confirmed cases of Mycobacterium tuberculosis complex infection, eight identified as M. bovis BCG, six corresponded to systemic adverse events post-BCG vaccine: two distant skin lesions, two osteomyelitis and two generalized infections. An altered immune response was detected in five of the six patients. One patient died of multiorgan failure, one was referred and four completed 12 months of treatment: two months of isoniazid, rifampin, ethambutol, and moxifloxacin, and 10 months of isoniazid and rifampin. They had good tolerance to medications, without relapse at two years. Conclusion Serious M. bovis BCG infection is a rare systemic complication of vaccination. It is reasonable to look for immunological defects in children who develop these types of adverse events.

15.

Endulzando el corazón: construcción participativa de herramientas de educación alimentaria y nutricional intercultural en Vaupés, Colombia
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Rodríguez, María C.

; González-Henao, Rosa T.

; Prada-Santos, Adelia M.

; Niño-Martínez, Tatiana

; Montoya-Lara, María J.

; Montoya-Chica, Pablo

Revista de Salud Pública

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feb 2023, Volume 25 N. 1 elocation 10

Abstract: Es En | Text: Es En | PDF: Es | PDF: En

RESUMEN Los pueblos indígenas continúan enfrentándose a diversas barreras de acceso a servicios de salud y nutrición y tienen poca representatividad e inclusión en los procesos de toma de decisiones sobre el tema. Las herramientas de educación alimentaria y nutricional (EAN) con las que cuenta el país no se adecúan a las realidades agroalimentarias de los pueblos indígenas del Vaupés. Este documento describe un proceso de co-construcción de materiales de EAN enfocados especialmente en gestantes, lactantes y niños y niñas menores de 2 años. El material se construyó con tres comunidades indígenas, un grupo de lideresas indígenas y las instituciones de salud locales del departamento del Vaupés. Se realizaron talleres y entrevistas y revisión documental. A partir de dicha información se construyó un rotafolio con 12 mensajes para fortalecer el inicio de la alimentación complementaria en los niños y las niñas con una visión intercultural y para apoyar los procesos de inducción y reinducción del personal que llega a trabajar al territorio. El material promueve las acciones contempladas por la legislación colombiana en las rutas integrales de atención, pero sobre todo las acciones de cuidado propias de los pueblos indígenas. Esta herramienta de EAN articula ambos saberes y aporta los elementos para promover la salud integralmente desde la perspectiva de las culturas locales.

ABSTRACT Indigenous peoples continue to face various barriers to accessing health and nutrition services, and they have little representation and inclusion in decision-making processes regarding these subjects. The food and nutrition education (FNE) tools currently available in the country are not adapted to the agro-food realities of the indigenous peoples of Vaupés. This document describes a process of co-constructing FNE materials focused on pregnant women, infants, and children under 2 years of age. The material was developed in collaboration with three indigenous communities, a group of indigenous leaders, and local health institutions in the department of Vaupés. The process included workshops, interviews, and documentary reviews. Based on this information, a flip chart with 12 messages was created to strengthen the initiation of complementary feeding in children with an intercultural vision and to support the training processes of health personnel who arrive to work in the territory. The material promotes health interventions that are contemplated by Colombian legislation in the comprehensive care routes, but above all, it prioritizes the health interventions of indigenous peoples. This FNE tool integrates both local knowledge and external expertise, providing the elements to promote a comprehensive approach to health that takes into account the local worldviews.

https://doi.org/10.15446/rsap.v25n1.104268

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