Search | SciELO

ABSTRACT Background: Critical illness is a major ongoing health care burden worldwide and is associated with high mortality rates. Sodium-glucose cotransporter-2 inhibitors have consistently shown benefits in cardiovascular and renal outcomes. The effects of sodium-glucose cotransporter-2 inhibitors in acute illness have not been properly investigated. Methods: DEFENDER is an investigator-initiated, multicenter, randomized, open-label trial designed to evaluate the efficacy and safety of dapagliflozin in 500 adult participants with acute organ dysfunction who are hospitalized in the intensive care unit. Eligible participants will be randomized 1:1 to receive dapagliflozin 10mg plus standard of care for up to 14 days or standard of care alone. The primary outcome is a hierarchical composite of hospital mortality, initiation of kidney replacement therapy, and intensive care unit length of stay, up to 28 days. Safety will be strictly monitored throughout the study. Conclusion: DEFENDER is the first study designed to investigate the use of a sodium-glucose cotransporter-2 inhibitor in general intensive care unit patients with acute organ dysfunction. It will provide relevant information on the use of drugs of this promising class in critically ill patients. ClinicalTrials.gov registry: NCT05558098

RESUMO Antecedentes: A doença crítica é um importante ônus permanente da assistência médica em todo o mundo e está associada a altas taxas de mortalidade. Os inibidores do cotransportador de sódio-glicose do tipo 2 têm demonstrado consistentemente benefícios nos desfechos cardiovasculares e renais. Os efeitos dos inibidores do cotransportador de sódio-glicose do tipo 2 em doenças agudas ainda não foram devidamente investigados. Métodos: O DEFENDER é um estudo de iniciativa do investigador, multicêntrico, randomizado, aberto, desenhado para avaliar a eficácia e a segurança da dapagliflozina em 500 participantes adultos com disfunção orgânica aguda hospitalizados na unidade de terapia intensiva. Os participantes aptos serão randomizados 1:1 para receber 10mg de dapagliflozina e o tratamento padrão por até 14 dias ou apenas o tratamento padrão. O desfecho primário é um composto hierárquico de mortalidade hospitalar, início de terapia renal substitutiva e tempo de internação na unidade de terapia intensiva, até 28 dias. O monitoramento da segurança será rigoroso durante todo o estudo. Conclusão: O DEFENDER é o primeiro estudo desenvolvido para investigar o uso de um inibidor do cotransportador de sódio-glicose do tipo 2 em pacientes de unidade de terapia intensiva geral com disfunção orgânica aguda. O estudo fornecerá informações relevantes sobre o uso de medicamentos dessa classe promissora em pacientes críticos. Registro ClincalTrials.gov: NCT05558098

https://doi.org/10.5935/2965-2774.20230129-en

SGLT-2 Inhibitors and Renal Outcomes in Non-Diabetic Patients: A Systematic Review
Facebook Twitter

Other social networks
Google+
LinkedIn
Reddit
StambleUpon
CiteULike
Mendeley
Other networks

Metrics
- SciELO Analytics
- Dimensions
- PlumX
- Altmetric

Sousa, Mariana Silva de

; Almeida, Cristiana Maia de

; Marchão, Natália

; Godinho, Iolanda

; Lopes, José António

; Gameiro, Joana

Portuguese Journal of Nephrology & Hypertension

Journal Metrics
- Sobre o periódico
- SciELO Analytics

jun 2023, Volume 37 N. 2 Pages 81 - 88

Abstract: En | Text: En | PDF: En

ABSTRACT Introduction: Sodium-glucose cotransporter 2 inhibitors (SGLT2i) have shown positive renal outcomes in diabetic patients. There is also emerging evidence in non-diabetic patients. This review was conducted to analyse the renal outcomes of SGLT2i in patients without diabetes mellitus (DM). Methods: A systematic review was performed in a Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) compliant manner. We included only randomized trials that examined the effect of SGLT2i on renal outcomes in non-diabetic patients. Results: A total of ten randomized trials were included with a combined cohort of 26 298 patients. There was a tendency for lesser risk of adverse renal outcomes in heart failure (HF) patients with reduced ejection fraction (EF) (hazard ratio (HR) 0.50-0.71). Lesser effect on adverse renal outcomes was seen in HF patients with preserved EF (HR 0.95). For both preserved and reduced EF HF, there was a statistically significant reduction in the rate of decline in estimated glomerular filtration rate (eGFR) (p<0.001). On a short follow-up, there was a significant reversible reduction in GFR. In the long term, chronic kidney disease (CKD) proteinuric patients had a statistically significant lesser risk of adverse renal outcomes (p<0.001) and a significant reduction in albuminuria (p=0.0016). CKD patients, including non-proteinuric, had a significant reduction in the rate of kidney disease progression (HR = 0.71). Conclusion: Treatment with SGLT2i significantly reduces the rate of kidney disease progression in CKD non-diabetic patients with eGFR ≥ 20 mL/min/1.73 m2. Benefit seems greater in proteinuric patients. Benefit for eGFR < 20 mL/min/1.73 m2, dialysis and kidney transplant patients is yet to be defined.

https://doi.org/10.32932/pjnh.2023.03.234

“Pensar com” José Mário Pires Azanha a elaboração do porvir educacional brasileiro
Facebook Twitter

Other social networks
Google+
LinkedIn
Reddit
StambleUpon
CiteULike
Mendeley
Other networks

Metrics
- SciELO Analytics
- Dimensions
- PlumX
- Altmetric

Amparo, Patrícia Aparecida do

; Lima, Ana Laura Godinho

; Catani, Denice Barbara

Estudos Avançados

Journal Metrics
- Sobre o periódico
- SciELO Analytics

aug 2022, Volume 36 N. 105 Pages 255 - 269

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Na situação pouco esperançosa imposta pela devastação a que nos submeteu o ano 2020, a inquietação acerca dos rumos possíveis para a educação num futuro próximo nos leva a procurar modos de propor a educação que se alicercem sobre valores de cuidado com o mundo. Assim, o artigo retoma o pensamento educacional de José Mário Pires Azanha e busca “pensar com” ele possibilidades educativas no nosso tempo. Ressalta-se como as formulações e ações do autor, tecidas no interior de sua produção teórica e atividades profissionais, têm oferecido elementos estruturantes aos debates acerca da escola, do trabalho pedagógico, das relações entre professores e alunos e da pesquisa educacional. Afirma-se, por exemplo, o modo como ele antecipou o empenho para com a justiça social educativa, expressa pela universalização do acesso à escola, na história educacional paulista. Unindo pensamento e ação o autor elabora proposições científicas e políticas num modelo de investigação educacional e de constituição da pedagogia que acolhe a vida e o trabalho escolar como construções sociais, valorizando a autonomia dos professores e das escolas na elaboração do projeto político pedagógico da instituição. Concebemos assim a reflexão contida no texto como uma situação exemplar para se compreender nossos “clássicos do pensamento educacional”, tomando a ideia de clássico a partir das sugestões de Ítalo Calvino.

ABSTRACT In the hopeless situation of devastation imposed upon the world’s population in 2020, concerns about the possible directions for education soon lead us to look for different proposals for an education based on values of care for humanity. This article discusses the educational thought of José Mário Pires Azanha and examines educational possibilities, formulations and actions he proposes in his theoretical production and professional activities. Azanha brings structuring elements to the debate about schools, pedagogical work, and the relations between teachers, students and educational research, as he anticipated the pedagogical commitment to social justice expressed by the universal access to education in São Paulo’s history. Bringing together thought and action, Azanha elaborates scientific propositions and policies based on a model of educational research and constitution of pedagogy that considers life and schoolwork as social constructions, valuing the autonomy of teachers and schools in developing an institution’s political pedagogical project. Thus, this study hopes to understand our classical pedagogical thought. The idea of “classic” is taken from Italo Calvino.

https://doi.org/10.1590/s0103-4014.2022.36105.015

Correlation of Physical Examination with Arthroscopic Findings in the Treatment of Rotator Cuff Tear
Facebook Twitter

Other social networks
Google+
LinkedIn
Reddit
StambleUpon
CiteULike
Mendeley
Other networks

Metrics
- SciELO Analytics
- Dimensions
- PlumX
- Altmetric

França, Flávio de Oliveira

; Godinho, Glaydson Gomes

; Freitas, José Márcio Alves

; Lang, Augusto Silveira

; Ammar, Charles Diogo

; Martinelli, Fabrício

Revista Brasileira de Ortopedia

Journal Metrics
- Sobre o periódico
- SciELO Analytics

jun 2022, Volume 57 N. 3 Pages 467 - 471

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Objetivo Comparar dados clínicos do exame físico com os achados artroscópicos na ruptura do manguito rotador. Métodos Foram selecionados 177 pacientes submetidos ao tratamento artroscópico de ruptura do manguito rotador e foram comparados os achados artroscópicos com o exame físico. Resultados Os testes irritativos de impacto apresentaram alta sensibilidade para ruptura do manguito rotador. Dentre os testes de força, o de maior sensibilidade foi o teste de Patte (85,7%) e o de maior valor preditivo positivo (VPP) foi o teste de Jobe (95%). O teste Drop Sign apresentou maior especificidade e valor preditivo negativo (VPN) (98,7 e 95,9%, respectivamente). Pacientes com história de trauma possuíam 3,5 vezes mais chances de apresentarem o teste Lift Off positivo. Conclusão Os testes irritativos tiveram alta sensibilidade para rupturas do manguito rotador. O teste de Jobe apresentou sensibilidade semelhante entre os pacientes que tinham lesão parcial ou total do supraespinhal. Para as lesões completas do subescapular, as testes Lift Off e Belly Press apresentaram alta sensibilidade e especificidade.

Abstract Objective To compare clinical data from the physical examination with arthroscopic findings in rotator cuff rupture. Methods A total of 177 patients submitted to arthroscopic treatment of rotator cuff rupture were selected, and arthroscopic findings were compared with physical examination. Results The impingement tests showed high sensitivity for rotator cuff rupture. Among the strength tests, the most sensitive was the Patte test (85.7%), and the one with the highest positive predictive value (PPV) was the Jobe test (95%). The Drop Sign test showed higher specificity and negative predictive value (NPV) (98.7 and 95.9%, respectively). Patients with a history of trauma were 3.5 times more likely to have a positive Lift Off test. Conclusion The impingement tests had high sensitivity for rotator cuff ruptures. The Jobe test showed similar sensitivity among patients who had partial or total supraspinal injury. For complete lesions of the subscapularis, The Lift Off and Belly Press tests showed high sensitivity and specificity.

https://doi.org/10.1055/s-0041-1735945

Anacardium occidentale L. (cajueiro) in the healing of skin wounds: an experimental study in rats
Facebook Twitter

Other social networks
Google+
LinkedIn
Reddit
StambleUpon
CiteULike
Mendeley
Other networks

Metrics
- SciELO Analytics
- Dimensions
- PlumX
- Altmetric

Silva, Dafni Cleia Gaia da

; Silva, Hanna Machado da

; Franco, Pedro Pastorini

; Carmo, Tomaz José Aquino Vasconcelos do

; Santos, Deivid Ramos dos

; Silveira, Edvaldo Lima

; Pinto, Ana Carla Godinho

; Andrade, Marcieni Ataíde de

; Chaves, Rosa Helena de Figueiredo

Acta Cirúrgica Brasileira

Journal Metrics
- Sobre o periódico
- SciELO Analytics

2022, Volume 37 N. 10 elocation e371006

Abstract: En | Text: En | PDF: En

ABSTRACT Purpose: To analyze the effects of Anacardium occidentale Linn on the healing of skin wounds. Methods: Twenty Wistar male rats were distributed into four groups (with five animals each one): negative control group (NCG), treated with saline solution; cashew tree group (CG), treated with hydroalcoholic extract of the bark of A. occidentale Linn; manipulated cashew tree group (MCG), with the ointment of extract of the bark of A. occidentale Linn; positive control group (PCG), treated with sunflower oil. All animals were examined daily, observing the macroscopic aspects of the surgical wound. Hematoxylin-eosin staining was used for tissue morphology analysis and Masson’s trichrome for better collagen fiber characterization. Results: On day 7, the MCG group had the expansion of the surgical wound covered by crust, exceeding the initial limits. On day 21, the wounds were observed to be completely closed and epithelialized in the NCG and CG groups. PCG and MCG still had remnants of crusts on the wound. The NCG was the only one not to present an abscess in histopathological analysis. Conclusions: There was a prolongation of the healing phase of the animals treated with the extract, and the animals in the NCG showed a better outcome by histological analysis.

https://doi.org/10.1590/acb371006

Evaluation of the Glenoid Track Tomographic Method in Magnetic Resonance Imaging/Arthro-MRI
Facebook Twitter

Other social networks
Google+
LinkedIn
Reddit
StambleUpon
CiteULike
Mendeley
Other networks

Metrics
- SciELO Analytics
- Dimensions
- PlumX
- Altmetric

Godinho, Andre Couto

; Godinho, Pedro Couto

; França, Flávio de Oliveira

; Ribeiro, Elísio José Salgado

; Toledo, Daniel Carvalho de

; Franco, Guilherme Henrique

Revista Brasileira de Ortopedia

Journal Metrics
- Sobre o periódico
- SciELO Analytics

nov 2021, Volume 56 N. 6 Pages 733 - 740

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Objetivo Comparar a avaliação do método glenoid-track (GT) em exames de tomografia computadorizada com reconstrução 3-D (TC-3D) com a avaliação realizada em exames de ressonância magnética (RM) e/ou artro-ressonância magnética (ARM). Métodos Quarenta e quatro ombros com diagnóstico clínico e radiográfico de instabilidade anterior traumática foram avaliados por meio de exames de TC-3D, RM e/ou ARM. As variáveis GT, intervalo de Hill-Sachs (IHS) e a perda óssea da glenoide (POG) foram realizadas por um médico radiologista, utilizando imagens de TC-3D, e classificadas em on-track/off-track. Três cirurgiões cegos à avaliação do radiologista realizaram o mesmo método utilizando RM/ARM. O estudo realizou análise descritiva, de variância, de associação da discordância de resultados, de concordância e curva característica de operação do receptor. Resultados Os resultados dos 4 examinadores foram totalmente concordantes em 61,4%. A RM/ARM diagnosticou lesões off-track com a sensibilidade variando de 35 a 65%, e lesões on-track com a especificidade variando de 91,67 a 95,83%. A acurácia variou de 68,1 a 79,5%. A maior divergência de dados ocorreu para o diagnóstico por RM/ARM de lesões off-track. A maior variabilidade dos dados ocorreu para o cálculo do IHS. Valores maiores de IHS e de POG foram associados a maior discordância entre os examinadores. A RM/ARM apresentou menor medida de valores de IHS quando comparado com a TC-3D. Ocorreu apenas moderada concordância no método GT entre a TC e a RM/ARM (Kappa 0,325-0,579). Conclusão A RM/ARM apresentou baixa acurácia e moderada concordância para o método GT, devendo ser utilizada com cautela por cirurgiões.

Abstract Objective To evaluate and compare the glenoid track method in 3D-reconstructed computed tomography (3D-CT) scans with magnetic resonance imaging (MRI) and/or arthro-MRI. Methods Forty-four shoulders with clinical and radiographic diagnosis of traumatic anterior instability were assessed using 3D-CT, MRI, and/or arthro-MRI scans. Glenoid track (GT), Hill-Sachs interval (HSI), and glenoid bone loss (GBL) were determined by a radiologist using 3D-CT images, and classified as on-track/off-track. Three surgeons, blinded to the radiologist’s evaluation, performed the same determinations using MRI/arthro-MRI. Descriptive analysis, variance analysis, results disagreement analysis, and receiver operating characteristic (ROC) curves were performed. Results Results from the 4 examiners were fully consistent in 61.4% of the cases. Magnetic resonance imaging/arthro-MRI diagnosed off-track injuries with 35 to 65% sensitivity and on-track injuries, with 91.67 to 95.83% specificity. Accuracy ranged from 68.1 to 79.5%. The greatest data divergence occurred for off-track injuries diagnosed by MRI/arthro-MRI. The greatest data variability referred to HSI calculation. Higher HSI and GBL values were associated with greater disagreement among examiners. Hill-Sachs interval values were lower at MRI/arthro-MRI when compared to 3D-CT. Agreement between CT and MRI/arthro-MRI for the GT method was only moderate (kappa value, 0.325-0.579). Conclusion Magnetic resonance imaging/arthro-MRI showed low accuracy and moderate agreement for the GT method; as such, it should be used with caution by surgeons.

https://doi.org/10.1055/s-0040-1716766

BIOLOGICAL NEMATICIDES ASSOCIATED WITH POULTRY LITTER IN THE CONTROL OF NEMATODES IN SOYBEAN AND SECOND CORN CROP
Facebook Twitter

Other social networks
Google+
LinkedIn
Reddit
StambleUpon
CiteULike
Mendeley
Other networks

Metrics
- SciELO Analytics
- Dimensions
- PlumX
- Altmetric

ROSA, TAYRLEN EDUARDO AMORIM

; SOUZA, JEAN CRAMENAK DE

; PEREIRA, WELLINGTON JOSÉ

; MOREIRA, JANAINA ALVES DE ALMEIDA

; ARAÚJO, FERNANDO GODINHO DE

Revista Caatinga

Journal Metrics
- Sobre o periódico
- SciELO Analytics

sep 2021, Volume 34 N. 3 Pages 580 - 589

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

ABSTRACT Alternative management measures have been used to reduce nematode population levels in affected areas. In this perspective, the objective was to evaluate the efficiency of nematicides based on fungus and bacterium, associated with poultry litter applied via ground in the management of Pratylenchus brachyurus and Heterodera glycines in soybean and corn crops in succession. The experiment was conducted in the 2018/19 growing season in the municipality of Ipameri– GO (-17°34’55.58”S−48°12’02.35”O) in naturally infested field, arranged in a randomized block design, with 10 treatments and 4 replicates, being: T1- Witness/ control, T2- Poultry litter, T3- P. lilacinum + T. harzianum, T4- B. subtilis + B. licheniformis, T5- P. chlamydosporia, T6- Abamectina, T7- P. lilacinum + T. harzianum + Poultry litter, T8- B. subtilis + B. licheniformis + Poultry litter, T9- P. chlamydosporia + Poultry litter, T10- Abamectina + Poultry litter. The poultry litter was added in the soil 10 days before planting. The plots were composed of 6 lines of 6 m, with a spacing of 0.5 m. In the soybean crop at 45 and 90 days after sowing (DAS), the fresh weight of the roots (MFR), nematological variables and productivity were evaluated. In corn, only nematological variables were evaluated at 60 DAS. The treatments using P. lilacinum + T. harzianum and B. subtillis + B. licheniformes increased the MFR and reduced the number of P. brachyurus and H. glycines at the root. P. chlamydosporia associated with poultry litter increased in productivity in soybean plants.

RESUMO Medidas alternativas de manejo têm sido utilizadas buscando reduzir níveis populacionais de nematoides em áreas afetadas. Nesta ótica, objetivou-se avaliar a eficiência de nematicidas biológicos a base de fungos e bactérias, associados a cama de aviário aplicada via solo no manejo de Pratylenchus brachyurus e Heterodera glycines na cultura da soja e milho em sucessão. O experimento foi conduzido na safra 2018/19 no município de Ipameri – GO (-17°34’55.58”S−48°12’02.35”O) em campo naturalmente infestado, disposto em delineamento de blocos casualizados, empregando 10 tratamentos e 4 repetições, sendo: T1- Testemunha, T2- Cama de frango, T3- P. lilacinum + T. harzianum, T4- B. subtilis + B. licheniformis, T5- P. chlamydosporia, T6- Abamectina, T7- P. lilacinum + T. harzianum + Cama de frango, T8- B. subtilis + B. licheniformis + Cama de frango, T9- P. chlamydosporia + Cama de frango, T10- Abamectina + Cama de frango. A cama de frango foi adicionada ao solo 10 dias antes do plantio. As parcelas foram compostas por 6 linhas de 6 m, com espaçamento de 0,5 m. Na cultura da soja aos 45 e 90 dias após a semeadura (DAS) avaliou-se a massa fresca das raízes (MFR), variáveis nematológicas e produtividade. No milho avaliou-se apenas as variáveis nematológicas aos 60 DAS. Os tratamentos empregando P. lilacinum + T. harzianum e B. subtillis + B. licheniformes elevaram a MFR e reduziram o número de P. brachurus e H. glycines na raiz. P. chlamydosporia associada a cama de frango promoveram incremento de produtividade em plantas de soja.

https://doi.org/10.1590/1983-21252021v34n309rc

Captured Rotator Cuff: A Poor Prognostic Factor in Rotator Cuff Repair
Facebook Twitter

Other social networks
Google+
LinkedIn
Reddit
StambleUpon
CiteULike
Mendeley
Other networks

Metrics
- SciELO Analytics
- Dimensions
- PlumX
- Altmetric

França, Flavio de Oliveira

; Freitas, José Márcio Alves

; Medeiros, Ricardo Palombini

; Queiroga, Romero Ruan Cartaxo de

; Nunes, Tiago Prause

; Godinho, Glaydson Gomes

Revista Brasileira de Ortopedia

Journal Metrics
- Sobre o periódico
- SciELO Analytics

feb 2021, Volume 56 N. 1 Pages 83 - 90

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Objetivo Descrever uma nova apresentação de ruptura e rerruptura do manguito rotador (MR), a qual denominamos manguito capturado (MC). Objetivamos também avaliá-la clinicamente e por meio de imagens. Métodos Foram avaliados retrospectivamente 16 pacientes com diagnóstico intraoperatório de MC no período de março de 2005 a setembro de 2017; por meio de exames de imagem (radiografia e ressonância magnética [RM]) e escores funcionais (UCLA e Constant & Murley). Nas imagens, analisamos a evolução para artropatia do manguito rotador e presença de rerrupturas. Funcionalmente, comparamos o lado afetado com o contralateral e as lesões extensas com nãoextensas. Resultados Cinco (31,25%) pacientes evoluíram com artropatia do manguito rotador e 10 (62,5%) tiveram rerrupturas. Três (75%) pacientes com lesões não extensas tiveram UCLA e Constant & Murley bons/excelentes. Nos pacientes com lesões extensas, quando avaliado Constant & Murley, 6 (50%) apresentaram resultados bons/excelentes, e no escore UCLA, 7 (58,3%). Comparando o lado acometido (Constant 74,72 pontos; UCLA 20 pontos) com o contralateral (Constant 96,96 pontos; UCLA 25,63 pontos), houve pior resultado funcional com significância estatística. Conclusão O diagnóstico de MC é suspeitado por achados característicos na RM e confirmado na artroscopia. Os ombros acometidos apresentam piores escores funcionais pós-operatórios.

Abstract Objective To describe a new presentation of tears and retears of the rotator cuff, which we denominate captured rotator cuff (CRC). We also aim to evaluate it clinically and through images. Methods We assessed retrospectively 16 patients with intraoperative diagnosis of CRC between March 2005 and September 2017; by means of imaging (radiography and magnetic resonance imaging [MRI]) and functional scores (UCLA and Constant & Murley). In images we analyzed the evolution for rotator cuff arthropathy and presence of retears. Functionally, we compared the affected side with the contralateral side and extensive lesions with nonextensive. Results Five (31.25%) patients presented with rotator cuff arthropathy, and 10 (62.5%) with retears. Three (75%) patients with nonextensive lesions had good/excellent UCLA and Constant & Murley scores. In patients with extensive lesions, when the Constant & Murley score was evaluated, 6 (50%) presented good/excellent results, and in the UCLA score, 7 (58.3%). Comparing the affected side (Constant 74.72 points; UCLA 20 points) with the contralateral side (Constant 96.96 points; UCLA 25.63 points), there were worse functional results with statistical significance. Conclusion The diagnosis of CRC is suspected by characteristic findings on MRI and confirmed in arthroscopy. The affected shoulders present worse functional postoperative scores.

https://doi.org/10.1055/s-0040-1702963 363 downloads

Plano de análise estatística para o estudo Balanced Solution versus Saline in Intensive Care Study (BaSICS)
Facebook Twitter

Other social networks
Google+
LinkedIn
Reddit
StambleUpon
CiteULike
Mendeley
Other networks

Metrics
- SciELO Analytics
- Dimensions
- PlumX
- Altmetric

Damiani, Lucas Petri

; Cavalcanti, Alexandre Biasi

; Biondi, Rodrigo Santos

; Freitas, Flávio Geraldo Rezende de

; Figueiredo, Rodrigo Cruvinel

; Lovato, Wilson José

; Amêndola, Cristina Prata

; Serpa Neto, Ary

; Paranhos, Jorge Luiz da Rocha

; Veiga, Viviane Cordeiro

; Guedes, Marco Antonio Vieira

; Lúcio, Eraldo de Azevedo

; Oliveira Júnior, Lúcio Couto

; Lisboa, Thiago Costa

; Lacerda, Fabio Holanda

; Miranda, Tamiris Abait

; Maia, Israel Silva

; Grion, Cintia Magalhães Carvalho

; Machado, Flavia Ribeiro

; Zampieri, Fernando Godinho

Revista Brasileira de Terapia Intensiva

Journal Metrics
- Sobre o periódico
- SciELO Analytics

dec 2020, Volume 32 N. 4 Pages 493 - 505

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Objetivo: Relatar o plano de análise estatística (primeira versão) para o estudo Balanced Solutions versus Saline in Intensive Care Study (BaSICS). Métodos: O estudo BaSICS é um ensaio multicêntrico fatorial e randomizado que avaliará os efeitos da administração dos fluidos Plasma-Lyte 148 em comparação com solução salina 0,9% como fluido de escolha em pacientes críticos, assim como os efeitos de uma velocidade de infusão lenta (333mL/hora) em comparação com uma velocidade de infusão rápida (999mL/hora) durante desafios com volume, em importantes desfechos do paciente. O tipo de fluido será mantido cego para os investigadores, pacientes e nas análises. Não será possível, entretanto, ocultar dos investigadores a velocidade de infusão, mas os procedimentos de análise serão mantidos cegos quanto a esse aspecto. Resultados: O estudo BaSICS terá como parâmetro primário a mortalidade em 90 dias, que será testada com utilização de modelos de risco proporcional de Cox de efeitos mistos, considerando os centros de estudo como variável randômica (modelos de fragilidade) ajustada por idade, disfunção de órgãos e tipo de admissão. Os parâmetros secundários importantes incluem terapia de substituição renal até 90 dias, insuficiência renal aguda, disfunção de órgãos nos dias 3 e 7 e dias sem ventilação mecânica em 28 dias. Conclusão: Este artigo fornece detalhes referentes à primeira versão do plano de análise estatística para o estudo BaSICS e orientará a análise do estudo após a conclusão do seguimento.

Abstract Objective: To report the statistical analysis plan (first version) for the Balanced Solutions versus Saline in Intensive Care Study (BaSICS). Methods: BaSICS is a multicenter factorial randomized controlled trial that will assess the effects of Plasma-Lyte 148 versus 0.9% saline as the fluid of choice in critically ill patients, as well as the effects of a slow (333mL/h) versus rapid (999mL/h) infusion speed during fluid challenges, on important patient outcomes. The fluid type will be blinded for investigators, patients and the analyses. No blinding will be possible for the infusion speed for the investigators, but all analyses will be kept blinded during the analysis procedure. Results: BaSICS will have 90-day mortality as its primary endpoint, which will be tested using mixed-effects Cox proportional hazard models, considering sites as a random variable (frailty models) adjusted for age, organ dysfunction and admission type. Important secondary endpoints include renal replacement therapy up to 90 days, acute renal failure, organ dysfunction at days 3 and 7, and mechanical ventilation-free days within 28 days. Conclusion: This manuscript provides details on the first version of the statistical analysis plan for the BaSICS trial and will guide the study’s analysis when follow-up is finished.

https://doi.org/10.5935/0103-507x.20200081 561 downloads

10.

Shoulder Arthroplasty: Tenotomy of the Subscapularis Tendon versus the Lesser Tuberosity Osteotomy
Facebook Twitter

Other social networks
Google+
LinkedIn
Reddit
StambleUpon
CiteULike
Mendeley
Other networks

Metrics
- SciELO Analytics
- Dimensions
- PlumX
- Altmetric

França, Flávio Oliveira

; Freitas, José Márcio Alves

; Mariosa, Carlos Alberto Menezes

; Bastiani, Carlos Eduardo

; Godinho, Glaydson Gomes

Revista Brasileira de Ortopedia

Journal Metrics
- Sobre o periódico
- SciELO Analytics

aug 2020, Volume 55 N. 4 Pages 463 - 469

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Objetivo Avaliar e comparar a função do músculo subescapular entre os grupos submetidos a tenotomia do subescapular (Grupo A) e osteotomia do tubérculo menor (Grupo B), em pacientes tratados por artroplastia anatômica total e parcial de ombros apresentando osteoartrose primária. Métodos Estudo retrospectivo de pacientes portadores de osteoartrose primária glenoumeral tratados cirurgicamente com prótese anatômica total ou parcial de ombro, avaliados por exame clínico, exames de imagens, escala visual analógica de dor e escore funcional de Constant e Murley. Foram avaliados 28 pacientes, totalizando uma amostra de 32 ombros operados. O seguimento mínimo foi de 12 meses (média 47,45 meses). Resultados Nos pacientes submetidos à tenotomia do tendão subescapular, dez obtiveram resultado ultrassonográfico com ruptura de sua espessura total (56%). A consolidação ocorreu em todos pacientes submetidos a osteotomia do tubérculo menor. Não houve diferença entre os grupos na comparação do teste Lift Off, da força nos testes Belly Press e Bear hug, e no escore de Constant e Murley. Conclusões Não encontramos diferença entre os grupos A e B na comparação do teste Lift Off, da força nos testes Belly Press e Bear hug, e no escore de Constant e Murley.

Abstract Objective To evaluate and compare subscapular muscle function among patients undergoing subscapular tenotomy (Group A) and lesser tuberosity osteotomy (Group B), in patients treated with total and partial anatomic shoulder arthroplasty for primary osteoarthrosis. Methods Retrospective study of patients with primary glenohumeral osteoarthrosis surgically undergoing total or partial anatomic shoulder prosthesis implant, evaluated by clinical examination, imaging exams, analogue pain scale and Constant and Murley functional score. A total of 28 patients were evaluated, totalizing a sample of 32 operated shoulders. The minimum follow-up was of 12 months (mean 47.45 months). Results Among patients submitted to subscapularis tendon tenotomy, 10 had an ultrasound with total rupture of its thickness (56%). All of the patients of the group B showed lesser tuberosity healing. There was no difference between groups comparing strength evaluated by Belly press and Bear hug tests as well as clinical outcome, through the Constant and Murley score. Conclusions We did not find differences between Groups A and B evidenciated by comparing strength in the Lift-off test, in the Belly press and Bear hug tests and through he Constant and Murley score.

https://doi.org/10.1055/s-0039-3402469 640 downloads

11.

Can diabetes mellitus modify the plasma concentrations of rifampicin in patients under treatment for tuberculosis?
Facebook Twitter

Other social networks
Google+
LinkedIn
Reddit
StambleUpon
CiteULike
Mendeley
Other networks

Metrics
- SciELO Analytics
- Dimensions
- PlumX
- Altmetric

Fonseca, Adriana Aparecida Durães

; Pinto, Ana Carla Godinho

; Paixão, Thiago Portal da

; Albério, Carlos Augusto Abreu

; Vieira, José Luiz Fernandes

Brazilian Journal of Infectious Diseases

Journal Metrics
- Sobre o periódico
- SciELO Analytics

aug 2020, Volume 24 N. 4 Pages 352 - 355

Abstract: En | Text: En | PDF: En

Abstract Rifampicin is a key component of treatment for tuberculosis and its efficacy is determined by the blood levels attained after therapeutic doses. However, there is a high variability of rifampicin blood levels that is related to both the patient and the formulation used. To date, the effect of diabetes mellitus on the plasma levels of rifampicin was low exploited, which could be relevant either by the significant increase of the comorbidity worldwide as by the probable influence of diabetes on the rifampicin exposure. The study aims to evaluate whether diabetes mellitus contribute to the variation of the maximum concentration of rifampicin in patients with tuberculosis treated with a daily dose of 10 mg/kg. Rifampicin and glycated hemoglobin were measured by high-performance liquid chromatography, and blood glucose by spectrophotometry. A total of 62 male patients were included in the study, and 26 presented diabetes mellitus. Rifampicin plasma levels in 2-h plasma samples collected at day 61 ranged from 3 µg/mL to 14.2 µg/mL. Drugs levels were similar between diabetic and non-diabetic patients and were not correlated with blood glucose and glycated hemoglobin. Moreover, a high percentage of patients in both groups presented low levels of rifampicin.

https://doi.org/10.1016/j.bjid.2020.05.007 375 downloads

12.

Concentrations of rifampicin in pre-dose samples in patients with pulmonary tuberculosis
Facebook Twitter

Other social networks
Google+
LinkedIn
Reddit
StambleUpon
CiteULike
Mendeley
Other networks

Metrics
- SciELO Analytics
- Dimensions
- PlumX
- Altmetric

Uchoa, Breno Kristoffer Beleza

; Albério, Carlos Augusto Abreu

; Pinto, Ana Carla Godinho

; Lucena, Stefania de Medeiros Araujo

; Vieira, José Luiz Fernandes

Brazilian Journal of Infectious Diseases

Journal Metrics
- Sobre o periódico
- SciELO Analytics

mar 2019, Volume 23 N. 2 Pages 130 - 133

Abstract: En | Text: En | PDF: En

ABSTRACT Rifampicin is used in both phases of treatment for tuberculosis. In chronic use, the short half-life and the self-induction of metabolism can decrease the levels of the drug below the minimal inhibitory concentration. The aim of the study was to investigate whether plasma concentrations of rifampicin are sustained above 0.5 µg/mL in patients with tuberculosis using 600 mg/day. Rifampicin was measured in plasma by high-performance liquid chromatography and a sputum smear microscopy was performed in all days of the study. A total of 44 male patients completed the study. On days 31, 61 and 91, the mean plasma concentrations of rifampicin were 0.6 (0.5) µg/mL, 0.55 (0.5) µg/mL and 0.46 (0.4) µg/mL. There was a high variation of rifampicin levels leading to a high percentage of samples with concentrations below 0.5 µg/mL. There was no significant association between the frequency of samples with drug levels below 0.5 µg/mL with the conversion of the sputum microscopy. These data suggest that pre-doses samples offer limited information on the exposure of M. tuberculosis to rifampicin.

https://doi.org/10.1016/j.bjid.2019.05.001 480 downloads

13.

Bases jurídicas e técnicas das sentenças dos Juizados Especiais Fazendários do Rio de Janeiro (RJ), 2012-2018
Facebook Twitter

Other social networks
Google+
LinkedIn
Reddit
StambleUpon
CiteULike
Mendeley
Other networks

Metrics
- SciELO Analytics
- Dimensions
- PlumX
- Altmetric

Saad, Elizabeth Maria

; Braga, José

; Maciel, Elvira Maria Godinho de

Saúde em Debate

Journal Metrics
- Sobre o periódico
- SciELO Analytics

2019, Volume 43 N. spe4 Pages 71 - 82

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO O trabalho analisa razões fáticas e jurídicas das decisões e sentenças prolatadas pelos Juizados Especiais da Fazenda Pública do município do Rio de Janeiro (2012-2018). Buscou-se conhecer como são tomadas as decisões sobre pedidos de medicamentos, perquirindo argumentos jurídicos, pareceres do Núcleo de Apoio Técnico do Tribunal (NAT) e evidências científicas. Foram recuperados 19.773 processos e realizada amostragem aleatória simples para seleção de 500 processos, dos quais 290 foram de medicamentos. Em 94,1% dos processos, usou-se apenas o laudo médico na decisão, seguido da prescrição médica; e, embora a consulta ao NAT seja obrigatória, o parecer técnico somente foi usado em 22,2%. De 221 sentenças de mérito, 94,6% basearam-se no art. 196 da Constituição Federal; 85,5%, em jurisprudência dos tribunais superiores; e 62,5%, afastadas teses da Fazenda Pública da reserva do possível e princípio da legalidade orçamentária. Medicamentos mais solicitados tratavam doenças endócrino-metabólicas (insulina, ranibizumabe), doenças renais (cinacalcete), complicações obstétricas (enoxaparina), doenças imunológicas e inflamatórias (adalimumabe). Apenas 32% dos pareceres recomendavam o medicamento com base científica, 14% 'não recomendado' e 54% 'recomendado sem base científica'. Conclui-se que o parecer técnico é pouco usado, mas quando presente, não explicita evidência científica, visto que, apenas nas causas obstétricas, 100% das recomendações tiveram base científica.

ABSTRACT The paper analyzes the factual and legal reasons and sentences issued by the Special Courts of the Public Treasury of the city of Rio de Janeiro (2012-2018). It was sought to know how decisions on medication requests are made, seeking legal arguments, opinions from the Court's Technical Support Center (TSC), and scientific evidence. A total of 19.773 processes were retrieved and a 500 processes simple random sample was selected, being 290 about drugs. In 94.1% of the cases, the decision was based on medical report, followed by the medical prescription; and, although TSC consultation is mandatory, the technical opinion was used only in 22.2%. Of 221 judgments on merits, 94.6% were based on article 196 of the Federal Constitution; 85.5% in jurisprudence of the higher courts; and 62.5% rejected theses of the Public Treasury from the reservation of the possible and principle of budgetary legality. Most requested drugs treated endocrine-metabolic diseases (insulin, ranibizumab), kidney diseases (cinacalcet), obstetric complications (enoxaparin), immune and inflammatory diseases (adalimumab). Only 32% had scientifically based drug recommendation, 14% 'not recommended', and 54% 'recommended without a scientific basis'. It is concluded that the technical opinion is little used, but when present, it does not explain scientific evidence, since, only in obstetric causes, 100% of the recommendations were scientifically based.

https://doi.org/10.1590/0103-11042019s407

14.

Bases jurídicas e técnicas das sentenças dos Juizados Especiais Fazendários do Rio de Janeiro (RJ), 2012-2018
Facebook Twitter

Other social networks
Google+
LinkedIn
Reddit
StambleUpon
CiteULike
Mendeley
Other networks

Metrics
- SciELO Analytics
- Dimensions
- PlumX
- Altmetric

Saad, Elizabeth Maria

; Braga, José

; Maciel, Elvira Maria Godinho de

Saúde em Debate

Journal Metrics
- Sobre o periódico
- SciELO Analytics

2019, Volume 43 N. spe4 Pages 71 - 82

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

https://doi.org/10.1590/0103-11042019s407 445 downloads

15.

Social determinants of pulmonary tuberculosis in Argentina
Facebook Twitter

Other social networks
Google+
LinkedIn
Reddit
StambleUpon
CiteULike
Mendeley
Other networks

Metrics
- SciELO Analytics
- Dimensions
- PlumX
- Altmetric

Hilal, Fernando Andrés

; Herrero, María Belén

; Maciel, Elvira Maria Godinho de Seixas

; Braga, Jose Ueleres

Revista Brasileira de Epidemiologia

Journal Metrics
- Sobre o periódico
- SciELO Analytics

2019, Volume 22 elocation e190003

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO: Introdução: Aproximadamente 9 mil novos casos de tuberculose (TB) por ano são registrados na Argentina, representando uma taxa de incidência de 22 casos por 100 mil habitantes. Não há estudos publicados que avaliaram os fatores que influenciam a distribuição desigual da doença na Argentina. O objetivo deste trabalho foi identificar a relação entre a distribuição dos fatores sociais e econômicos e da tuberculose na Argentina entre 2008 e 2012. Método: Foi realizado um estudo ecológico envolvendo 525 departamentos. Na análise procedeu-se uma regressão linear simples, seguida de regressão linear múltipla para cada grupo de determinantes. Um modelo final com os determinantes da incidência de TB foi construído por meio de regressão linear múltipla. Resultados: Os seguintes determinantes explicam 43% da variabilidade da taxa de incidência de TB entre diferentes jurisdições: aglomeração intradomiciliar, proporção de domicílios com rede de esgoto, proporção de pacientes examinados com sintomas respiratórios e proporção de pacientes com tratamento descontinuado. Discussão: Este estudo contribui de maneira importante para uma melhor compreensão dos fatores que influenciam a ocorrência da TB na Argentina, resultado de um processo multidimensional e complexo. Esses fatores fazem parte da determinação social dessa doença. Conclusão: A incidência de TB está associada a diferentes determinantes, de múltiplos níveis. A heterogeneidade na distribuição da tuberculose na Argentina deve-se, entre outros fatores, pela distribuição desigual de determinantes sociais e de acesso às ações de saúde.

ABSTRACT: Background: In Argentina, approximately 9,000 new cases of tuberculosis (TB) are recorded every year, representing an incidence rate of 22 cases per 100,000 inhabitants. There are no reported studies in Argentina examining the factors that influence the unequal distribution of the disease. The aim of the study was to identify the relationship between the distribution of social and economic factors and TB in Argentina between 2008 and 2012. Method: An ecologic study involving 525 departmental jurisdictions was conducted. Simple linear regression analysis was performed, followed by multiple linear regression for each group of determinants. A final model of determinants of TB’s incidence was constructed from a model of multiple linear regression. Results: The following determinants explain 43% of the variability of TB’s incidence rate among different jurisdictions: overcrowding, proportion of households with a sewage network, proportion of examined patients with respiratory symptoms and proportion of patients who discontinued treatment. Discussion: This study makes an important contribution to a better understanding of the factors influencing the TB occurrence in Argentina, which is the result of a multidimensional and complex process. Thesefactors make part of this disease’s social determination. Conclusion: TB incidence is associated with different determinants, from multiple levels. Inequalities in its distribution in Argentina are driven by the unequal distribution of key social determinants.

https://doi.org/10.1590/1980-549720190003

Showing

itens per page

Page of 6 Next

Select one or more results

All Alphabetic

Results

Comparative chart Download CSV

Statistics of

Send result

To*

Use ; (semicolon) to insert more emails.

Send to email

This page

Selected records

All references (max. 300)

Your email

Subject

Comments

Export format:

RIS (for EndNote, ProCite, Reference Manager, RefWorks, Citavi, etc.)

BibTeX

Citation

CSV (for Excel, etc)

Export:

This page

Selected itens

All references (max. 2000)

Sem resultados

No documents were found for your search

Glossary and search help

You can enrich your search in a very simple way. Use the search indexes combined with the connectors (AND or OR) and specify more your search.

For example, if you want to search for articles about
cases of dengue in Brasil in 2015, use:
ti:dengue and publication_year:2015 and aff_country:Brasil

See below the complete list of search indexes that can be used:

Index code	Element
ti	article title
au	author
kw	article keywords
subject	subject (title words, abstract and keywords)
ab	abstract
ta	journal short title (e.g. Cad. Saúde Pública)
journal_title	journal full title (e.g. Cadernos de Saúde Pública)
la	publication language code (e.g. pt - Portuguese, es - Spanish)
type	document type
pid	publication identifier
publication_year	publication year of publication
sponsor	sponsor
aff_country	country code of the author's affiliation
aff_institution	author affiliation institution
volume	article volume
issue	article issue
elocation	elocation
doi	DOI number
issn	journal ISSN
in	SciELO colection code (e.g. scl - Brasil, col - Colômbia)
use_license	article usage license code

SciELO - Scientific Electronic Library Online
Rua Dr. Diogo de Faria, 1087 – 9º andar – Vila Clementino 04037-003 São Paulo/SP - Brasil
Email: scielo@scielo.org

All the contents of this site www.scielo.br, except where otherwise noted, is licensed under a Creative Commons Attribution License.
more »