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ABSTRACT Objective: To evaluate autoinflammatory diseases (AID) according to age at diagnosis and sex, and response to therapy in a large population. Methods: This is a cross-sectional observational study of a Latin American registry using a designed web system for data storage, collected between 2015 and 2018. Any altered findings during follow-up were recorded. The forms were translated into Portuguese and Spanish, including demographic, clinical, laboratory, genetic and treatment characteristics. Results: We included 152 patients, 51.3% male and 75% Caucasian. The median age at disease onset was 2.1 years (0–15.6 years) and median age at diagnosis 6.9 years (0–21.9 years); 111 (73%) were children (0–9 years old), and 41 (27%) were adolescents and young adults (AYA) (10–21 years old). Periodic fever, aphthous stomatitis, pharyngitis, and adenitis syndrome (PFAPA) occurred in 46/152 (30%), chronic non-bacterial osteomyelitis (CNO) in 32/152 (21%), and familial Mediterranean fever (FMF) in 24/152 (15.7%). PFAPA was significantly higher in young children than in AYA (38.7% vs. 7.3%, p<0.001), while CNO were lower (13.5% vs. 41.5%, p<0.001). The frequency of females was significantly higher in CNO (28.4% vs. 14.1%, p=0.031) and lower in FMF (8.1% vs. 23.1%, p=0.011). The most used drugs were glucocorticoids, non-steroidal anti-inflammatory drugs (NSAID), and colchicine. Glucocorticoids and colchicine treatment were used in all AID with good to moderate response. However, cryopyrin-associated periodic syndromes (CAPS) seemed unresponsive to glucocorticoids. NSAIDs and methotrexate were the main medications used to treat CNO. Conclusions: Differences among AID patients were observed in the LA population regarding sex and age at disease diagnosis.

RESUMO Objetivo: Avaliar as doenças autoinflamatórias (DAI) de acordo com sexo e idade no momento do diagnóstico e a resposta terapêutica em uma grande população. Métodos: Este é um estudo observacional transversal de um registro latino-americano que usou um sistema de dados coletados entre 2015 e 2018. Quaisquer achados alterados ao longo do acompanhamento foram registrados. Os formulários foram traduzidos para os idiomas português e espanhol, incluindo características demográficas, clínicas, laboratoriais, genéticas e de tratamento. Resultados: Incluímos 152 pacientes, sendo 51,3% do sexo masculino e 75% da raça branca. A média de idade de início da doença foi de 2,1 anos (0–15,6 anos) e a média de idade de diagnóstico 6,9 anos (0–21,9 anos); 111 (73%) eram crianças (0–9 anos) e 41 (27%) adolescentes/adultos jovens (10–21 anos). A síndrome de febre periódica, estomatite aftosa, faringite e adenite (PFAPA) ocorreu em 46/152 (30%), osteomielite não bacteriana crônica (CNO) em 32/152 (21%) e febre familiar do Mediterrâneo (FMF) em 24/152 (15,7%). A PFAPA foi significativamente maior em crianças pequenas (38,7 vs. 7,3%, p<0,001), e a CNO, em adolescentes/adultos jovens (13,5 vs. 41,5%, p<0,001). A frequência do sexo feminino foi significativamente maior na CNO (28,4 vs. 14,1%, p=0,031) e menor na FMF (8,1 vs. 23,1%, p=0,011). Os medicamentos mais utilizados foram glicocorticoides, anti-inflamatórios não esteroidais (AINE) e colchicina. O tratamento com glicocorticoides e colchicina foi usado em todas as DAI com resposta boa a moderada. No entanto, as síndromes periódicas associadas à criopirina (CAPS) pareciam não responder aos glicocorticoides. AINE e metotrexato foram os principais medicamentos utilizados no tratamento da CNO. Conclusões: Diferenças de pacientes com DAI foram observadas na população latino-americana em pacientes agrupados por sexo e idade ao diagnóstico da doença.

https://doi.org/10.1590/1984-0462/2024/42/2022184

Pollen Available During Anthesis of Hylocereus Undatus Flowers
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Del Ángel-Pérez, Ana Lid

; Nataren-Velazquez, Jeremías

; Megchun-Garcia, Juan Valente

; Martínez-Hernández, María de Jesús

; Estrada-López, Mariel

Enfoque UTE

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dec 2023, Volume 14 N. 4 Pages 53 - 63

Abstract: Es En | Text: Es En | PDF: Es | PDF: En

Resumen: La pitahaya (Hylocereus spp) es un fruto que, por las características de su demanda, tanto para fruta fresca como para consumo industrial, ha detonado fuertemente su desarrollo en diversos países. in embargo, presenta diversos mecanismos de autoincompatibilidad que impacta en la productividad. Por lo anterior, se analizó la viabilidad del polen durante la antesis (o periodo de floración) de dos cultivares de H. undatus de pulpa blanca. Para ello se tomó muestras de polen durante 13 horas, desde el comienzo de ésta por la tarde, hasta que finaliza al día siguiente. El método utilizado fue tinción con sal de tetrazolio (cloruro de 2,3,5-trifeniltetrazolio) o TZ. Los resultados mostraron que no hay polen viable al inicio de la antesis. A las 09:00 pm la viabilidad comenzó a crecer lentamente y después de las 12:00 am se duplicó y se aceleró la viabilidad, marcando la más alta de 02:00 a 04:00 am. Se pudo observar la consistencia del polen que inicia con una fase I con polen húmedo sin viabilidad, hasta otra con menor humedad con baja viabilidad (fase II). La fase III, observó polen harinoso muy granulado, fácil de manejar precisamente cuando las lecturas de la tinción marcaron la viabilidad de 93 % a 95 %. Posteriormente, la viabilidad baja hasta desaparecer cuando la estructura floral comienza a deshidratarse.

Abstract: Pitahaya (Hylocereus spp) is a fruit that, due to the characteristics of its demand, both for fresh fruit and for industrial consumption, has detonated its development in various countries. However, it presents various self-incompatibility mechanisms that impact productivity. Therefore, the viability of pollen was analyzed during the anthesis (or flowering period)of two white-fleshed H. undatus cultivars, taking pollen samples for 13 hours, from the beginning of the anthesis in the afternoon, until it ends the following day. The method used was staining with tetrazolium salt (2,3,5-triphenyltetrazolium chloride) or TZ. The results showed that there is no viable pollen at the beginning of the anthesis. At 09:00 pm the viability began to grow slowly and after 12:00 am it doubled and the viability accelerated, marking the highest from 02:00 to 04:00 am. It was possible to observe the consistency of the pollen that begins with a phase I with humid pollen without viability, up to another with lower humidity with low viability (phase II). Phase III observed very granular mealy pollen, easy to handle precisely when the staining readings marked the viability of 93 % to 95 %. Subsequently, the viability decreases until it disappears when the floral structure begins to dehydrate.

https://doi.org/10.29019/enfoqueute.976

Qualidade de vida e engajamento no trabalho em profissionais de enfermagem no início da pandemia de COVID-19
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Carvalho, Taisa Moitinho de

; Lourenção, Luciano Garcia

; Pinto, Maria Helena

; Viana, Renata Andrea Pietro Pereira

; Moreira, Ana Maria Batista da Silva Gonçalves

; Mello, Leticia Pepineli de

; Medeiros, Gilney Guerra de

; Gomes, Antonio Marcos Freire

Ciência & Saúde Coletiva

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oct 2023, Volume 28 N. 10 Pages 2903 - 2913

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo O artigo investiga a correlação entre engajamento e qualidade de vida no trabalho dos profissionais de enfermagem de um hospital público do interior do estado de São Paulo, no início da pandemia de COVID-19. Estudo transversal, descritivo e correlacional, com profissionais de enfermagem, realizado entre dezembro de 2020 e janeiro de 2021. Foram utilizadas as versões brasileiras da Utrecht Work Engagement Scale (UWES) e da Escala de Avaliação da Qualidade de Vida no Trabalho (QVT), segundo modelo de Walton. Os profissionais de enfermagem apresentaram correlação forte e positiva (r≥0.70) entre o domínio integração social da QVT e a dimensão vigor da UWES (r=0,88; p=<0,001); correlação positiva moderada (r≥0.40≤0.69) entre as condições de trabalho (QVT) e as dimensões vigor (r=0,40; p=<0,001), dedicação (r=0,40; p=<0,001) e escore geral (r=0,41; p=<0,001) da UWES. As correlações foram positivas e fracas (r≤0.39) para os demais domínios da QVT e as dimensões da UWES. Concluiu-se que os profissionais com níveis satisfatórios de qualidade de vida tendem a ter níveis mais altos de engajamento no trabalho. No início da pandemia de COVID-19, os profissionais de enfermagem estavam fortemente engajados e satisfeitos com sua qualidade de vida no trabalho.

Abstract This article investigates the correlation between work engagement and work-related quality of life among nursing staff at a public hospital in São Paulo State, at the onset of the COVID-19 pandemic. A descriptive, correlational, cross-sectional study of nursing personnel was conducted from December 2020 to January 2021, using the Brazilian versions of the Work & Well-being Survey (Utrecht Work Engagement Scale - UWES) and the Work-related Quality of Life (WRQoL) scale, following Walton’s model. Nursing staffs returned a strong positive correlation (r≥0.70) between the social integration domain of the WRQoL and the vigour dimension of the UWES (r=0.88; p=<0.001); a moderate positive correlation (r≥0.40≤0.69) between working conditions (WRQOL) and the vigour (r=0.40; p<0.001), dedication (r=0.40; p<0.001) and overall score (r=0.41; p<0.001) dimensions of the UWES. Correlations were positive and weak (r≤0.39) for the other WRQoL domains and the UWES dimensions. It was concluded that personnel with satisfactory levels of quality of life tend to show higher levels of engagement at work. At the onset of the COVID-19 pandemic, nursing professionals were strongly engaged and satisfied with their work-related quality of life.

https://doi.org/10.1590/1413-812320232810.09982023

Qualidade de vida e engajamento no trabalho em profissionais de enfermagem no início da pandemia de COVID-19
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Carvalho, Taisa Moitinho de

; Lourenção, Luciano Garcia

; Pinto, Maria Helena

; Viana, Renata Andrea Pietro Pereira

; Moreira, Ana Maria Batista da Silva Gonçalves

; Mello, Leticia Pepineli de

; Medeiros, Gilney Guerra de

; Gomes, Antonio Marcos Freire

Ciência & Saúde Coletiva

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oct 2023, Volume 28 N. 10 Pages 2903 - 2913

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

https://doi.org/10.1590/1413-812320232810.09982023

La vacuna de ARNm para el tratamiento del cáncer de páncreas llegó para quedarse
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Chuluyan, Eduardo

; Davio, Carlos

; Dusetti, Nelson

; Fraunhoffer, Nicolás

; Garcia, María Noé

; Garona, Juan

; González, Betina

; Gottardo, Florencia

; Grasso, Daniel

; Iovanna, Juan

; Kohan, Gustavo

; Lada, Paul Eduardo

; Mazza, Oscar

; Monte, Martín

; Papademetrio, Daniela

; Pasqualini, María Eugenia

; Sahores, Ana

; Santofimia, Patricia

; Yaneff, Agustín

Medicina (Buenos Aires)

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aug 2023, Volume 83 N. 4 Pages 650 - 652

Abstract: Es | Text: Es | PDF: Es

Hypersensitivity reaction to Patent Blue Dye
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Presa, Ana R.

; Garcia, Sónia

; Cadinha, Susana

; Sousa, Maria João

Revista Portuguesa de Imunoalergologia

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jun 2023, Volume 31 N. 2 Pages 163 - 167

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

ABSTRACT Patent Blue Dye (PBD) is a synthetic blue dye commonly used in medical practice for sentinel lymph node mapping in breast cancer. The authors report the case of a patient with invasive ductal carcinoma of the left breast, who underwent unilateral mastectomy with sentinel lymph node mapping. During surgery, the patient developed violaceous urticaria and mild glottic edema. A hypersensitivity reaction to PBD was confirmed by skin prick tests and methylene blue was identified as a possible alternative dye. This article reinforces the need for greater awareness of the possible hypersensitivity reactions to PBD during surgical procedures.

RESUMO O Azul patente (AP) é um corante azul sintético comummente usado na prática clínica para o mapeamento do gânglio sentinela no cancro da mama. Os autores reportam o caso de uma doente com carcinoma ductal invasivo da mama esquerda, submetida a mastectomia unilateral com mapeamento de gânglio sentinela. Durante a cirurgia, a doente desenvolveu urticária violácea e edema glótico ligeiro. Foi confirmada reação de hipersensibilidade ao AP através de testes cutâneos, tendo sido identificado o azul-de-metileno como um possível corante alternativo. Este caso reforça a necessidade de maior consciencialização sobre as possíveis reações de hipersensibilidade ao AP durante procedimentos cirúrgicos.

https://doi.org/10.32932/rpia.2023.06.114

Impact of hepatitis C virus eradication with direct-acting antivirals on glycidic metabolism
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Sparvoli, Jucéli Márcia Hendges

; Sparvoli, Antonio Cardoso

; Dumith, Samuel de Carvalho

; Pereira, Afonso Alexandre

; Paula, Ana Luisa Machado de

; Garcia, Laís

; Belarmino, Vanusa

; Hora, Vanusa Pousada da

; Martínez, Ana Maria Barral de

; Gonçalves, Carla Vitola

Archives of Endocrinology and Metabolism

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jun 2023, Volume 67 N. 3 Pages 314 - 322

Abstract: En | Text: En | PDF: En

ABSTRACT Objective: To compare the glucose metabolism of patients with chronic hepatitis C virus infection treated with direct-acting antivirals (DAAs) in pretreatment and sustained viral response (SVR) periods. Materials and methods: This was an intervention pre-post study of 273 patients with chronic hepatitis C virus infection treated with DAAs from March 2018 to December 2019. Glycidic metabolism was evaluated through homeostasis model assessment (HOMA) – insulin resistance (IR) and HOMA-β indices and assessments of insulinemia and HbA1c levels. These parameters were analyzed with a T test by paired comparison of the means of the variables and Wilcoxon's test paired for the median; in the variables with an abnormal distribution, the Z score was generated for the mean in both the pretreatment and SVR periods. Statistical significance was considered at p ≤ 0.05. Results: Among 273 participants, 125 (45.8%) had prediabetes, and 50 (18.3%) had diabetes. In SVR, there was a significant increase in platelets, albumin, alkaline phosphatase, cholesterol and triglycerides and a significant decrease in aspartate aminotransferase, alanine aminotransferase, gamma GT and bilirubin. The HOMA-IR and HOMA-β indices increased in SVR from 1.95 to 2.29 (p = 0.087) and 71.20 to 82.60 (p = 0.001), respectively. Insulinemia increased from 7.60 μU/mL to 8.90 μU/mL (p = 0.011). HbA1c decreased from 5.6 to 5.4 (p < 0.001). Among patients with prediabetes and those with diabetes, the reduction in HbA1c values was significant (p = 0.006 and p = 0.026, respectively). Conclusion: SVR significantly impacts and leads to improvement in glucose metabolism in patients with chronic liver disease induced by hepatitis C virus.

https://doi.org/10.20945/2359-3997000000543

Desenvolvimento do Pensamento Crítico: Questões de Género no Contexto da Formação em Artes no Ensino Superior
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Silva, Ana Maria Garcia Nolasco da

; Bárrios, Jorge Manuel Garrido

; Santos, Kátia Couto de Sá Sabino dos

Convergências - Revista de Investigação e Ensino das Artes

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may 2023, Volume 16 N. 31 Pages 85 - 96

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

Abstract This study aims to analyze the development of critical thinking on gender issues in the context of higher education training, taking as a case study the work proposal "Gender(s)" which aimed to carry out a transdisciplinary project articulated between the Curricular Units of Workshop of Arts, Technologies and Multimedia IV (OATM IV) - Sculpture and Multimedia Art modules - and Art Theory, of the 2nd semester of the academic year 2019/2020, promoting reflection on the issue of Gender and critical thinking of undergraduate students in Visual Arts and Technologies of the School of Education of the Polytechnic of Lisbon. The aim of this project is to promote reflection on the gender issue and critical thinking among undergraduate Visual Arts and Technologies students at the School of Education of the Polytechnic of Lisbon.During the process, teachers assumed the role of facilitators, creating a space free of censorship, finding that students mobilized and developed critical thinking, in processes of investigation and artistic creation around gender stereotypes. The imagination of different gender possibilities led to a reflection about values as cultural constructions and to the awareness of each one's agency to reinvent them and contribute to social change. In this way, we consider that artistic production and/or interpretation of art works stimulate autonomous thinking, capable of dealing with new situations, through the projection of several alternative hypotheses. We conclude, therefore, that art education is a privileged space to stimulate the development of critical thinking, without resorting to preconceived ideas, being, therefore, potentially able to combat class, culture or gender stereotypes and, in this way, contribute to the creation of values that guide a socially fair action.

Resumo Este artigo pretende analisar o desenvolvimento do pensamento crítico sobre questões de género no contexto da formação no ensino superior, tomando como caso de estudo a proposta "Género(s)", que visou a realização de um projeto transdisciplinar articulado entre as Unidades Curriculares de Oficina de Artes, Tecnologias e Multimédia IV (OATM IV) - módulos de Escultura e Arte Multimédia - e de Teoria da Arte, do 2º semestre do ano letivo de 2019/2020, promovendo a reflexão sobre a questão de género e o pensamento crítico dos estudantes de Licenciatura em Artes Visuais e Tecnologias da Escola Superior de Educação do Politécnico de Lisboa. No decorrer do processo, os professores assumiram um papel de facilitadores, criando um espaço livre de censura e constatando que os estudantes mobilizaram e desenvolveram o pensamento crítico em processos de investigação e criação artística em torno de estereótipos sobre questões de género. A imaginação de diferentes possibilidades de géneros levou a uma reflexão sobre os valores enquanto construções culturais e à consciência do agenciamento de cada um para os reinventar e contribuir para a mudança social. Deste modo, consideramos que a produção artística e/ou a interpretação de obras de arte estimulam o pensamento autónomo, capaz de lidar com situações novas, através da projeção de várias hipóteses alternativas. Concluímos, assim, que a educação artística é um espaço privilegiado para estimular o desenvolvimento do pensamento crítico, sem recorrer a ideias pré-concebidas, sendo por isso potencialmente apto a combater os estereótipos de classe, cultura ou género e, deste modo, contribuir para a criação de valores orientadores de uma ação socialmente justa.

https://doi.org/10.53681/c1514225187514391s.31.177

Conhecimento de mulheres que fazem sexo com mulheres sobre Infecções Sexualmente Transmissíveis e Aids
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Parenti, Ana Beatriz Henrique

; Ignácio, Mariana Alice de Oliveira

; Buesso, Thayná Santos

; Almeida, Margareth Aparecida Santini de

; Parada, Cristina Maria Garcia de Lima

; Duarte, Marli Teresinha Cassamassimo

Ciência & Saúde Coletiva

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jan 2023, Volume 28 N. 1 Pages 303 - 303

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo O objetivo deste artigo é estudar o conhecimento de mulheres que fazem sexo com mulheres sobre Infecções Sexualmente Transmissíveis e Aids. Estudo transversal com 260 mulheres, sendo 81 mulheres que fazem sexo com mulheres ou com mulheres e homens (MSM) e 179 mulheres que fazem sexo exclusivamente com homens (MSH). Dados obtidos entre 2019 e 2020, por meio de aplicação de formulário e de instrumentos validados. Para estudar a associação entre parceria sexual e nível de conhecimento sobre Infecções Sexualmente Transmissíveis e Aids foram ajustados modelos de regressão múltipla de Cox, sendo significativas as associações com p<0,05. A mediana do percentual de acerto das questões foi inferior entre às MSM quando comparadas às das MSH [68% (18-96) vs 75% (14-96); p=0,023]. Fazer sexo com mulher [RP=2,36 (1,07-5,21); p=0,033] e escolaridade menor que 11 anos de estudo [RP=2,64 (1,12-6,21); p=0,026] associaram-se independentemente ao baixo conhecimento. As MSM apresentaram menor nível de conhecimento sobre Infecções Sexualmente Transmissíveis e Aids do que as MSH, assim como a menor escolaridade associou-se independentemente a esse desfecho.

Abstract This article aims to study the knowledge of women who have sex with women about Sexually Transmitted Infections and AIDS. Cross-sectional study of 260 women, 81 women who either have sex with women or with men and women (WSW) and 179 women who have sex exclusively with men (WSM). Data were collected in 2019/2020 by means of a form and validated instruments. To study the association between sexual partnership and level of knowledge about Sexually Transmitted Infections and AIDS, multiple Cox regression models were adjusted, producing significant associations of p<0,05. The median percentage of correct answers was lower among WSW when compared to WSM [68% (18-96) vs 75% (14-96); p=0.023]. Having sex with woman [PR=2.36 (1.07-5.21); p=0.033] and less than 11 years of schooling [PR=2.64 (1.12-6.21); p=0.026] were independently associated with low knowledge. WSW had a lower level of knowledge about Sexually Transmitted Infections and AIDS than WSM, and lower education was independently associated with this finding.

https://doi.org/10.1590/1413-81232023281.09882022

10.

Conhecimento de mulheres que fazem sexo com mulheres sobre Infecções Sexualmente Transmissíveis e Aids
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Parenti, Ana Beatriz Henrique

; Ignácio, Mariana Alice de Oliveira

; Buesso, Thayná Santos

; Almeida, Margareth Aparecida Santini de

; Parada, Cristina Maria Garcia de Lima

; Duarte, Marli Teresinha Cassamassimo

Ciência & Saúde Coletiva

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jan 2023, Volume 28 N. 1 Pages 303 - 303

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

https://doi.org/10.1590/1413-81232023281.09882022

11.

Psicometria brasileira da escala do medo da morte de Collett-Lester
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Andrade, Ana Maria Garcia

; Silva, José Vitor da

; Baptista, Makilim Nunes

Revista Bioética

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2023, Volume 31 elocation e3283PT

Abstract: En Es Pt | Text: En Es Pt | PDF: En | PDF: Es | PDF: Pt

Abstract Methodological study conducted with 279 individuals to evaluate the reliability of the Collett-Lester fear of death scale and relate it to the spiritual well-being scale. Its multifactorial structure was confirmed by four dimensions and 24 items. Internal consistency obtained Cronbach’s α of 0.951. Pearson’s correlation (r=0.87 and p =0.000) confirmed stability. Collett-Lester fear of death scale showed positive correlation with three of the four spiritual well-being scale items, ranging from weak to moderate magnitudes. The Collett-Lester fear of death scale proved to be reliable for the Brazilian reality.

Resumen Estudio metodológico que evalúa la confiabilidad de la escala de miedo a la muerte de Collett-Lester y la relaciona con la escala de bienestar espiritual en una muestra de 279 personas. La estructura multifactorial de la escala se confirmó en cuatro elementos y 24 ítems. La consistencia interna obtuvo el α de Cronbach de 0,951. La estabilidad se confirmó mediante la correlación de Pearson (r=0,87 y p =0,000). La correlación de la escala de miedo a la muerte de Collett-Lester ocurrió con tres de los cuatro factores de la escala de bienestar espiritual, siendo positiva y variando de magnitudes bajas a moderadas. La escala de miedo a la muerte de Collett-Lester es confiable al contexto brasileño.

Resumo Estudo metodológico para avaliar a confiabilidade da escala de medo da morte de Collett-Lester e relacioná-la com a escala de bem-estar espiritual em amostra de 279 pessoas. A estrutura multifatorial da escala foi confirmada por quatro dimensões e 24 itens. A consistência interna obteve α de Cronbach: 0,951. A estabilidade foi confirmada pela correlação de Pearson (r=0,87 e p =0,000). A correlação escala de medo da morte de Collett-Lester ocorreu com três dos quatro fatores da escala de bem-estar espiritual, sendo positiva e variando de magnitudes fracas a moderadas. A escala de medo da morte de Collett-Lester se mostrou confiável à realidade brasileira.

https://doi.org/10.1590/1983-803420233283pt

12.

Development and characterization of bacterial cellulose membrane incorporated with Witch hazel extract
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Molin, Maria Luiza

; Segat, Bruna

; Garcia, Michele Cristina Formolo

; Pezzin, Ana Paula Testa

; Silveira, Márcia Luciane Lange

; Schneider, Andrea Lima dos Santos

Matéria (Rio de Janeiro)

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2023, Volume 28 N. 2 elocation e20230008

Abstract: En | Text: En | PDF: En

ABSTRACT Bacterial cellulose (BC) has stood out in the biomedical field for its biocompatibility, non-toxicity and high liquid absorption capacity. Thus, studies have been conducted aiming at the functionalization of BC with substances that add properties, such as anti-inflammatory and antimicrobial action. Hamamelis virginiana plant extract is known for its astringent, anti-inflammatory and antimicrobial properties. Thus, the present work aimed to incorporate aqueous (AE) and glycolic (GE) extracts of witch hazel in different concentrations to BC, aiming at its application as a curative. BC membranes incorporated with the extracts were characterized by thermogravimetric analysis (TGA), Fourier transforms infrared spectroscopy (FTIR), scanning electron microscopy (SEM) and antimicrobial activity. The TGA results indicated a reduction in thermal stability and the appearance of a new stage of degradation in the samples that underwent incorporation. Furthermore, the FTIR showed the presence of aromatic compounds not found in the BC, corroborating the TGA. The micrographs revealed that the incorporation of the extracts resulted in the formation of a film on the surface of the membranes, covering the nanofibers. These results show that incorporating the aqueous and glycol extracts in the BC membrane was successful. However, despite the crude extracts’ antimicrobial potential, antimicrobial activity in the functionalized BC samples was not observed.

https://doi.org/10.1590/1517-7076-rmat-2023-0008

13.

High and low-fidelity simulation for respiratory diseases pediatric training: a prospective and randomized study
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Valente, Beatriz Cristina Heitmann Gomes

; Melo, Maria do Carmo Barros de

; Liu, Priscila Menezes Ferri

; Gonçalves, Beatriz Adriane Rodrigues

; Gomes, Romina Aparecida dos Santos

; Martins, Isadora Guimarães

; Oliveira, Ana Clara Pereira Lage de

; Ferreira, Ana Luísa de Cássia Magalhães

; Bothrel, Rafaella Garcia

; Lasmar, Laura Maria de Lima Belizário Facury

Jornal de Pediatria

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2023, Volume 99 N. 5 Pages 521 - 528

Abstract: En | Text: En | PDF: En

Abstract Objective: To compare high and low-fidelity simulations for the recognition of respiratory distress and failure in urgency and emergency pediatric scenarios. Methods: 70 fourth-year medical students were randomly distributed in high and low-fidelity groups and simulated different types of respiratory problems. Theory tests, performance checklists, and satisfaction and self-confidence questionnaires were used in the assessment. Face-to-face simulation and memory retention was applied. The statistics were evaluated by averages and quartiles, Kappa, and generalized estimating equations. The p-value was considered 0.05. Results: In the theory test there was an increase in scores in both methodologies (p < 0.001 ); in memory retention (p = 0.043) and at the end of the process the high-fidelity group had better results. The performance in the practical checklists was better after the second simulation (p > 0,05). The high-fidelity group felt more challenged in both phases (p = 0.042; p = 0.018) and showed greater self-confidence to recognize changes in clinical conditions and in memory retention (p = 0.050). The same group, in relation to the hypothetical real patient to be treated in the future, felt better confident to recognize respiratory distress and failure (p = 0.008; p = 0.004), and better prepared to make a systematic clinical evaluation of the patient in memory retention (p = 0.016). Conclusion: The two levels of simulations enhance diagnostic skills. High fidelity improves knowledge, leads the student to feel more challenged and more self-confident in recognizing the severity of the clinical case, including memory retention, and showed benefits regarding self-confidence in recognizing respiratory distress and failure in pediatric cases.

https://doi.org/10.1016/j.jped.2023.04.007

14.

Cognitive profile of patients with and without speech impairment in Parkinson's disease
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Sousa, Nariana Mattos Figueiredo

; Diniz, Juliana de Fátima Garcia

; Galvão, Ana Paula

; Brucki, Sonia Maria Dozzi

Dementia & Neuropsychologia

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2023, Volume 17 elocation e20220093

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

ABSTRACT. Cognitive functions have been the subject of studies evaluating the pathophysiological mechanism of speech control. Objective: To compare the groups of patients with and without speech disorders with cognitive assessment, demographic, and clinical data (disease duration, functionality, and motor symptoms). Methods: Retrospective, cross-sectional study. Patients were evaluated using the Addenbrooke's Cognitive Examination III and neuropsychological tests. The following speech subsystems were analyzed: articulation, phonation, resonance, and prosody, through auditory-perceptual evaluation (based on the Protocol for the Evaluation of Acquired Speech Disorders in Individuals with Parkinson's Disease — PADAF Protocol tests), observing aspects of speech programming and execution. The patients were distributed into three subgroups (normal cognition, mild cognitive impairment, and dementia). After speech evaluation, they were divided into two subgroups (with and without speech disorders). Results: A total of 150 patients participated in this study, 104 men and 46 women, 63.58 (8.81) years of age, 11.03 (4.00) years of schooling, 6.61 (4.69) years of disease progression, and with the highest proportion of individuals in stage I–II of the Hoehn & Yarh (H&Y) scale (86, or 57.33%). Statistically significant differences were observed between subgroups with and without speech alteration. Worse performance was verified in the Trail Making Test (TMT) TMT-Δ and a tendency of difference in the TMT-B of the subgroup with speech disorders, in addition to worse severity of motor symptoms (H&Y) and cognitive complaints. Conclusion: Individuals with speech disorders brought more frequent cognitive complaints and impairment below expected in tests assessing executive functions. Future studies, with stratification by type of speech disorder, are necessary to contribute to and validate these results.

RESUMO. As funções cognitivas têm sido alvo de estudos que avaliam o mecanismo patofisiológico do controle da fala. Objetivo: Comparar subgrupos de pacientes com e sem alterações de fala quanto à avaliação cognitiva, dados demográficos e clínicos (tempo de evolução da doença, funcionalidade e gravidade dos sintomas motores). Métodos: Estudo retrospectivo, de corte transversal. Os pacientes foram avaliados pelo Exame Cognitivo de Addenbrooke III e testes neuropsicológicos. Foram analisados os seguintes subsistemas da fala: articulação, fonação, ressonância e prosódia, por meio de avaliação perceptivo-auditiva (baseada em testes do Protocolo de Avaliação dos Distúrbios Adquiridos de Fala em Indivíduos com Doença de Parkinson — PADAF), sendo observados aspectos da programação e execução da fala. Os pacientes foram distribuídos em três subgrupos (cognição normal, comprometimento cognitivo leve e demência). Após a avaliação da fala, foram divididos em dois subgrupos (com desordens da fala e sem desordens da fala). Resultados: Participaram deste estudo 150 pacientes, 104 homens e 46 mulheres, com 63,58 (8,81) anos de idade, 11,03 (4,00) anos de escolaridade e 6,61 (4,69) anos de evolução da doença, e maior proporção de indivíduos no estágio I–II da Escala de Hoehn & Yarh — H&Y (86, ou 57,33%). Foram observadas diferenças estatisticamente significantes entre os subgrupos com e sem alteração da fala. Houve pior desempenho no Trail Making Test (TMT) TMT-Δ e tendência de diferença no TMT-B no subgrupo com desordens da fala, além de pior gravidade dos sintomas motores (H&Y) e queixa cognitiva. Conclusão: Os indivíduos com desordens da fala trouxeram queixas cognitivas com maior frequência e prejuízo abaixo do esperado nos testes que avaliam as funções executivas. Estudos futuros, com estratificação por tipo de distúrbio da fala, são necessários para a contribuição e validação destes resultados.

https://doi.org/10.1590/1980-5764-dn-2022-0093

15.

Clarity of publications on HPV in Instagram profiles of official health agencies in Brazil
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NUNES, Wanúbia Barbosa

; FIRMINO, Ramon Targino

; MARINHO, Angélica Maria Cupertino Lopes

; BARRETO, Lílian de Sá

; SOUSA, Myrelle Leal Campos

; SILVA, Samara Ellen da

; COSTA, Edja Maria Melo de Brito

; PERAZZO, Matheus França

; GRANVILLE-GARCIA, Ana Flávia

Brazilian Oral Research

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2023, Volume 37 elocation e103

Abstract: En | Text: En | PDF: En

Abstract The study analyzed the clarity of publications on human papillomavirus (HPV) in the Instagram profiles of official Brazilian health agencies. An infodemiological study analyzed publications on HPV in the 81 Instagram profiles selected from the Health Ministry, States’ Health Departments, and dental councils and associations. The following data were collected: classification of content, type of profiles, type of media, how the content was addressed, number of posts, frequency, likes, comments, viewings, and hashtags, and how the HPV vaccine was addressed. The clarity of the educational publications was assessed using the Brazilian version of the Clear Communication Index (BR-CDC-CCI). Data analysis was performed with Spearman’s correlation and the Mann-Whitney test (p < 0.05). A total of 504 publications on HPV were found. The average number of likes was 528.3 (SD = 2388.2) and the average BR-CDC-CCI score was 67.1 (SD = 14.1). The quality and clarity of the information was considered adequate (BR-CDC-CCI score ≥ 90) in 6.9% of the publications. A weak positive correlation was found between the number of likes and both the BR-CDC-CCI score (r = 0.195) and number of posts (r = 0.124). Publications from the Health Ministry had a significantly higher BR-CDC-CCI score (72.9) compared to the other profiles analyzed (p = 0.01). Most publications concerned government actions, had low engagement, and written educational information was of low clarity and quality. However, the effort to reach the population was evident, with an increase in publications over the years.

https://doi.org/10.1590/1807-3107bor-2023.vol37.0103

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