SUMMARY INTRODUCTION: The congenital absence of the vagina is an uncommon condition, some causes are the Mayer-Rokitansky-Küster-Hauser syndrome and peripheral insensitivity to androgens. Multiple surgical and non-surgical techniques have been described for the management of this condition, being the main objective the creation of a vaginal canal of adequate diameter and length to restore coital function. The objective of this study is to detail the experience of the neovagina procedure with the McIndoe surgical technique performed in patients with Mayer-Rokitansky-Küster-Hauser syndrome at the Clinica Universitaria Bolivariana. METHODOLOGY: Report of five cases of patients with vaginal agenesis secondary to the Mayer-Rokitansky-Kuster-Hauser syndrome, who underwent neovagina with the McIndoe technique and some modifications in the mold for the skin implant. RESULTS: Five patients with diagnosis of Mayer-Rokitansky-Kuster-Hauser were included, all had development of secondary sexual characteristics, normal hormonal profile, and a XX karyotype. The McIndoe surgical technique was used to perform the neovagina without associated intraoperative complications and with adequate postoperative evolution, with a vaginal length between 7-9 cm and three patients with active sexual life. The length of hospital stay was 7 to 9 days. CONCLUSION: The McIndoe surgical technique is an option to restore sexual function in women with vaginal agenesis with favorable results. The time to decide its realization is elective, however, they must have the physical and emotional maturity to be carried out. The patients in our report have an average age of 18 years.

RESUMEN INTRODUCCIÓN: La ausencia congénita de vagina es una condición poco común, algunas causas son el síndrome de Mayer-Rokitansky-Kuster-Hauser y la insensibilidad periférica a los andrógenos. Múltiples técnicas quirúrgicas y no quirúrgicas se han descrito para el manejo de esta condición, siendo el objetivo principal la creación de un canal vaginal de diámetro y longitud adecuada que permitan restaurar la función coital. El objetivo de este estudio es detallar la experiencia del procedimiento de neovagina con la técnica quirúrgica de McIndoe en pacientes con Mayer-Rokitansky-Kuster-Hauser realizados en la Unidad de Uroginecología de la Clínica Universitaria Bolivariana. METODOLOGÍA: Reporte de 5 casos de pacientes con agenesia de vagina secundarios al síndrome de Mayer-Rokitansky-Kuster-Hauser, a las cuales se les realizó neovagina con la técnica de McIndoe con algunas modificaciones en el molde para el implante de piel. RESULTADOS: Se incluyeron cinco pacientes con diagnóstico de Mayer-Rokitansky-Kuster-Hauser, todas tenían desarrollo de características sexuales secundarias, perfil hormonal normal, y un cariotipo XX. Se utilizó la técnica quirúrgica de McIndoe para la realización de la neovagina sin complicaciones intraoperatorias asociadas y con adecuada evolución posoperatoria, con una longitud vaginal entre 7-9 cm y 3 pacientes con vida sexual activa. El tiempo de estancia hospitalaria fue 7 a 9 días. CONCLUSIÓN: La técnica quirúrgica de McIndoe es una opción para restaurar la función sexual en mujeres con agenesia vaginal con resultados favorables. El tiempo para decidir su realización es electivo, sin embargo, se debe contar con madurez física y emocional para ser llevado a cabo. Las pacientes de nuestro reporte tenían una edad promedio de 18 años.

RESUMO Foram conduzidos dois experimentos com o objetivo de determinar o valor nutricional e avaliar o desempenho e características da carcaça de suínos alimentados com farelo de canola (Brassica napus). No Experimento I, foi conduzido um ensaio de digestibilidade total com 14 suínos mestiços de linhagem comercial, machos castrados, com 60,69 ± 4,26 kg de PV inicial. O alimento teste farelo de canola (FC), substituiu em 25% a ração referência à base de milho e farelo de soja. Cada suíno constituiu uma unidade experimental, totalizando sete unidades experimentais por ração. Os valores de energia digestível (ED) e energia metabolizável (EM) na matéria natural para o FC foram de 2995 kcal/kg e 2796 kcal/kg, respectivamente. No Experimento II, foram utilizados 50 suínos mestiços, com peso vivo inicial de 29,90 ± 1,16 kg e final de 60,33 ± 3,38 kg, na fase de crescimento, e peso vivo inicial de 60,37 ± 1,6 kg e final de 90,37 ± 3,19 kg na fase de terminação. Foi utilizado o delineamento de blocos inteiramente casualizados, com quatro tratamentos, (6, 12, 18 e 24% de FC), com 10 repetições e um suíno por unidade experimental. Adicionalmente, foi formulada uma ração testemunha, contendo 0% de FC. Os dados foram submetidos à análise de variância e adicionalmente foi aplicado o Teste de Dunnett, e análise de regressão, a 5% de probabilidade. Os resultados sugerem que é possível incluir até 24% de FC nas dietas de suínos, em crescimento e terminação, sem prejudicar o desempenho e as características da carcaça.

ABSTRACT Two experiments were performed for the purpose of determining the nutritional value and assess the performance and carcass traits in pigs fed on canola meal (Brassica napus). Experiment I consisted of a total digestibility trial conducted with 14 castrated commercial crossbred male pigs with 60.69 ± 4.26 kg initial live weight. The treatments consisted of a control diet based on maize and soybean meal and another diet containing canola meal (control + 25% canola meal). Each pig was an experimental unit, totalling seven experimental units per diet. The digestible energy and the metabolizable energy of canola meal used was 2,999 and 2,730 kcal.kg-1, respectively. These values were used to formulate the diets of the performance experiment. Experiment II included 50 crossbred pigs with an average initial live weight of 29.90 ± 1.16 kg and an average final live weight of 60.33 ± 3.38 kg during the growing phase, and an average initial live weight of 60.37 ± 1.6 kg and an average final live weight of 90.37 ± 3.19 kg during the finishing phase. The experimental design consisted of randomized blocks, with four treatments (6, 12, 18, and 24% canola meal), 10 repetitions, and one pig per experimental unit. The control diet was formulated with 0% canola meal. The data were assessed using ANOVA test and the averages of the treatments were compared using Dunnett's test and regression analysis at a 5% probability level. The results suggest that it is possible to use up to 24% canola meal in the diets for pigs during the growing and finishing phases without affecting the performance and carcass traits.

Two experiments were carried out to evaluate the reduction of crude protein (CP) in diets supplemented with synthetic amino acids for piglets of 15 to 30 kg. In the performance assay (Exp I), 60 piglets with initial weight of 15.34±0.87 kg and final weight of 30.08±1.59 kg were distributed in a randomized block design with six replicates, five treatments and two animals per experimental unit. The treatments consisted of five diets in which the CP was reduced by 1.5 percentage points, resulting in low-protein diets (19.24, 17.74, 16.24, 14.74 and 13.24%), meeting the requirements of amino acids with inclusion of L-lysine, DL-methionine, L-threonine, L-tryptophan, L-valine and L-isoleucine. The average daily gain and feed conversion according to the Linear Response Plateau model (LRP) were estimated at 14.23 and 14.79% of CP, respectively. As the CP levels were reduced, there was an increase in the essential:non-essential amino acids ratio. The plasma urea concentration decreased linearly, indicating that there was a better use for amino acids with the CP reduction. In the nitrogen balance (Exp II), 30 crossbred barrow piglets with average weight of 21.69±4.46 kg were housed in metabolic cages, distributed in a completely randomized design with five treatments and six replicates, and the experimental unit consisted of a piglet. The biological protein value in the diets remained above the ideal (70%), in which the level of 13.24% CP corresponded to the highest value. There was no difference in levels of urea in blood and urine. Reduction of protein levels is efficient in decreasing the pollution effect in the excreta, with lower nitrogen excretion in feces and urine.

La paragonimiasis es una zoonosis parasitaria, de transmisión alimentaria, causada por especies de tremátodos del género Paragonimus, presente en áreas tropicales y subtropicales de Asia, África y América. El ser humano se infecta mediante la ingestión de crustáceos de agua dulce crudos o mal cocidos. La infección afecta principalmente los pulmones, con desarrollo de múltiples manifestaciones clínicas y radiológicas, dependiendo del momento del ciclo vital del parásito. El diagnóstico diferencial más importante de esta enfermedad es la tuberculosis pulmonar. En este artículo se describe esta enfermedad en dos niñas con diferentes manifestaciones pulmonares. La paragonimiasis se debe sospechar en pacientes con tos crónica, esputo herrumbroso, dolor torácico, con o sin compromiso cerebral, que viven o han residido en una zona endémica y que presentan una eosinofília elevada, con cambios radiológicos sugestivos del síndrome de Loeffler.

Paragonimiasis is a parasitic, food-borne zoonosis, caused by species of trematodes of the genus Paragonimus, found in tropical and subtropical areas of Asia, Africa and America. Human beings become infected by ingestion of raw or undercooked freshwater shellfish. The infection primarily affects the lungs, with the development of multiple clinical and radiological manifestations, depending on the moment in the life cycle of the parasite. The most important differential diagnosis of this disease is pulmonary tuberculosis. We report two cases of lung paragonimiasis in aboriginal Colombian girls with different pulmonary manifestations. Paragonimiasis should be suspected in patients with chronic cough, rusty sputum, chest pain, with or without brain involvement, who live or have lived in endemic areas and have a high-level eosinophilia with radiographic changes suggestive of Loeffler's syndrome.