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Abstract Hereditary transthyretin amyloidosis with peripheral neuropathy (ATTRv-PN) is an autosomal dominant inherited sensorimotor and autonomic polyneuropathy with over 130 pathogenic variants identified in the TTR gene. Hereditary transthyretin amyloidosis with peripheral neuropathy is a disabling, progressive and life-threatening genetic condition that leads to death in ~ 10 years if untreated. The prospects for ATTRv-PN have changed in the last decades, as it has become a treatable neuropathy. In addition to liver transplantation, initiated in 1990, there are now at least 3 drugs approved in many countries, including Brazil, and many more are being developed. The first Brazilian consensus on ATTRv-PN was held in the city of Fortaleza, Brazil, in June 2017. Given the new advances in the area over the last 5 years, the Peripheral Neuropathy Scientific Department of the Brazilian Academy of Neurology organized a second edition of the consensus. Each panelist was responsible for reviewing the literature and updating a section of the previous paper. Thereafter, the 18 panelists got together virtually after careful review of the draft, discussed each section of the text, and reached a consensus for the final version of the manuscript.

Resumo Polineuropatia amiloidótica familiar associada a transtirretina (ATTRv-PN) é uma polineuropatia sensitivo-motora e autonômica hereditária autossômica dominante com mais de 130 variantes patogênicas já identificadas no gene TTR. A ATTRv-PN é uma condição genética debilitante, progressiva e que ameaça a vida, levando à morte em ~ 10 anos se não for tratada. Nas últimas décadas, a ATTRv-PN se tornou uma neuropatia tratável. Além do transplante de fígado, iniciado em 1990, temos agora 3 medicamentos modificadores de doença aprovados em muitos países, incluindo o Brasil, e muitas outras medicações estão em desenvolvimento. O primeiro consenso brasileiro em ATTRv-PN foi realizado em Fortaleza em junho de 2017. Devido aos novos avanços nesta área nos últimos 5 anos, o Departamento Científico de Neuropatias Periféricas da Academia Brasileira de Neurologia organizou uma segunda edição do consenso. Cada panelista ficou responsável por rever a literatura e atualizar uma parte do manuscrito. Finalmente, os 18 panelistas se reuniram virtualmente após revisão da primeira versão, discutiram cada parte do artigo e chegaram a um consenso sobre a versão final do manuscrito.

https://doi.org/10.1055/s-0043-1764412

Influence of the degree of saturation and the wetting front on the stability of cliffs: a case study on a cliff located on the beach of Tabatinga-RN-Brazil
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Medeiros, Allan Benício Silva de

; Silva, Romário Stéffano Amaro da

; Santos, Valteson da Silva

; Santos Junior, Olavo Francisco dos

; Severo, Ricardo Nascimento Flores

; Freitas Neto, Osvaldo de

; Lira, Bruna Silveira

Soils and Rocks

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2023, Volume 46 N. 4 elocation e2023005423

Abstract: En | Text: En | PDF: En

Abstract Coastal zones are of great interest in civil engineering due to their economic relevance and active geological dynamics. In Brazil, the development of these regions is related to the use of their geomorphological features in the landscape, among which the cliffs stand out. Although there are studies that consider the influence of the wetting front in stability analysis with cliffs, in general, the studies only consider extreme saturation situations (dry and saturated). In this sense, the present study aims to understand the influence of the wetting front and the degree of saturation reached by the materials in the stability of cliffs composed of Barreiras Formation soil. The stability analyses were carried out using the limit equilibrium method and stress analysis, varying the degrees of saturation of the materials and wetting fronts of a model of a cliff located at Praia de Tabatinga, State of Rio Grande do Norte, Brazil. Failures were identified, in different wetting fronts, by the limit equilibrium method from degrees of saturation around 20%, and by the stress analysis method around 40%. Thus, it was concluded that the variation in the degree of saturation has a preponderant effect on the destabilization of a cliff, since partial saturations are already enough to trigger significant mass movements. It was also noticeable that the wetting front is a relevant effect on instability, although conditioned to the degree of saturation reached, which may enhance the order of magnitude of the identified failures.

https://doi.org/10.28927/sr.2023.005423

Prospecção de tecnologias sustentáveis de drenagem de águas pluviais como insumo para propositura de mudanças no Plano Diretor do município de Frutal, Minas Gerais Frutal
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Fogatti, Osvaldo de Freitas

; Millan, Rodrigo Ney

; Martins, Eduardo da Silva

Engenharia Sanitaria e Ambiental

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2023, Volume 28 elocation e20220149

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Sistemas de drenagem urbana sustentáveis (SUDS) são tecnologias que dispensam as tradicionais galerias pluviais e têm como premissa a sustentabilidade. Frutal, município do estado de Minas Gerais, sofre com problemas de drenagem pluvial e está em processo de atualização de seu plano diretor. O objetivo do trabalho é discutir, em termos teóricos, a aplicação dos SUDS nesse município, apresentando sugestões para seu plano diretor, bem como realizar a prospecção de tecnologias SUDS para fundamentar futuros estudos técnicos acerca da aplicação dessas tecnologias em Frutal, contribuindo com a literatura sobre SUDS. Para tanto, adotou como procedimentos metodológicos o estudo de caso, a revisão de literatura e o mapeamento de patentes. Como resultados, o trabalho identificou os pontos críticos de inundações e processos erosivos em Frutal, enfatizando os problemas de inundação nos bairros Centro, XV de Novembro, Princesa Isabel, Jardim das Laranjeiras, Progresso, Novo Horizonte e Caju, e de processos erosivos nos bairros Ipê Amarelo e Waldemar Marchi. Expôs uma série de diretrizes sobre os SUDS que poderão nortear eventuais mudanças no plano diretor e futuros projetos legislativos e técnicos, como incentivos econômicos e campanhas de conscientização acerca dessa tecnologia, e fornece exemplos de tecnologias patenteadas que poderão ser referência para posteriores ações de drenagem urbana, especialmente do tipo pavimentos permeáveis, sobretudo para áreas com elevado índice de ocupação do solo e com dificuldades para instalação de equipamentos superficiais de drenagem. (SUDS sustentabilidade Frutal Gerais discutir teóricos tanto caso patentes resultados Centro Novembro Isabel Laranjeiras Progresso Caju Marchi tecnologia permeáveis

ABSTRACT Sustainable urban drainage systems (SUDS) are technologies that dispense traditional storm sewers and are premised on sustainability. It was found that Frutal, in the state of Minas Gerais, Brazil, suffers from problems with rainwater drainage and is in the process of updating its Master Plan. Therefore, this work aimed to discuss, in theoretical terms, the application of SUDS in this Municipality, presenting suggestions for its, as well as prospecting SUDS technologies to support future technical studies on the application of these technologies in the Municipality, also contributing to the literature on SUDS. For that, this study adopted a case study, literature review, and patent mapping as a methodological procedure. As a result, the work identified the critical points of flooding and erosion processes in the municipality of Frutal, emphasizing the problems of flooding in the Centro, XV de Novembro, Princesa Isabel, Jardim das Laranjeiras, Progresso, Novo Horizonte, and Caju districts, and erosion processes in the Ipê Amarelo and Waldemar Marchi districts. It exposes a series of SUDS guidelines that may lead eventual changes in the Master Plan and future legislative and technical projects, such as economic incentives and awareness campaigns about this technology, and provides examples of patented technologies that may be a reference for subsequent urban drainage actions, especially of the permeable pavement type, for areas with a high rate of soil occupation and with difficulties in installing surface drainage equipment. (SUDS sustainability Frutal Gerais Brazil Therefore discuss terms Municipality review procedure result Centro Novembro Isabel Laranjeiras Progresso Horizonte districts projects technology actions type equipment

https://doi.org/10.1590/s1413-415220220149

Potencialidade de uso do resíduo da scheelita em sistemas de cobertura de aterro de resíduos
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Gondim, Tiago Feitosa

; Ingunza, Maria del Pilar Durante

; Freitas Neto, Osvaldo de

; Santos Júnior, Olavo Francisco dos

Engenharia Sanitaria e Ambiental

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jun 2022, Volume 27 N. 3 Pages 597 - 606

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO O aproveitamento de resíduos de mineração em cadeias produtivas como a da construção civil é uma importante solução ambiental para a gestão das atividades de mineração. Pesquisadores têm demonstrado que diferentes tipos de resíduos de mineração podem ser incorporados a alguns tipos de obras geotécnicas cumprindo a função de barreira hidráulica. Nesse cenário, a utilização do resíduo da scheelita em obras de aterro de resíduos poderia ser uma solução ambientalmente sustentável para esse material. Tendo isso em vista, este trabalho tem como objetivo avaliar a viabilidade técnica do emprego dos resíduos da mineração da scheelita como revestimento compactado, visando atender à função de barreira hidráulica em sistemas de cobertura de aterros de resíduos. Para tanto, primeiramente foram coletadas amostras dos resíduos finos e grossos gerados durante o beneficiamento da scheelita na Mina Brejuí, em Currais Novos (Rio Grande do Norte). Posteriormente, foram definidos quatro materiais a serem estudados, um composto exclusivamente do resíduo fino (F100) e outros três formados pela mistura entre os dois resíduos coletados (F75G25, F50G50 e F25G75). Em seguida, foram realizados, em cada amostra, ensaios de caracterização física, compactação, condutividade hidráulica em permeâmetros de parede flexível, fluorescência de raios X/ difratometria de raios X e microscópio eletrônico de varredura. Como resultados dos testes, os valores da permeabilidade saturada obtidos para F100 e F75G25, por serem, respectivamente, 2,18x10−8 e 7,07x10−8 m.s, atenderam às exigências de normativas internacionais e, assim, demonstram-se viáveis à aplicação como barreira hidráulica de cobertura de resíduos. Quanto aos demais compósitos, embora não se tenham mostrado aptos à utilização pretendida, poderiam ser aplicados com outras finalidades em um aterro de resíduos, como em camadas de regularização e/ou proteção. Dessa forma, os resultados obtidos demonstram a viabilidade técnica do uso pretendido para o material.

ABSTRACT ABSTRACT: The use of mining residues within production chains, such as civil construction, is an important environmental solution for the management of mining activities. Researchers have shown that different types of mining residues can be incorporated into some types of geotechnical works, fulfilling the function of hydraulic barrier. In this scenario, the use of scheelite residue in landfill works could be an environmentally sustainable solution for this material. This work aimed to evaluate the technical viability of using scheelite mining residues as a compacted coating with hydraulic barrier function in waste landfill covering systems. For this, samples of fine and coarse residues generated during the scheelite processing were collected at the Brejuí Mine, in Currais Novos (Rio Grande do Norte). Subsequently, four materials were defined to be studied, one composed exclusively by the fine residue (F100) and three others formed by mixing the two collected residues (F75G25, F50G50, and F25G75). After that, physical characterization, compaction, hydraulic conductivity tests on flexible wall permeameters, X-ray Flourescence Spectroscopy/X-ray Powder Diffraction and Scanning electron microscope were performed on each sample. As a result of the tests, the saturated permeability values obtained for F100 and F75G25, being 2.18x10−8 and 7.07x10−8 m.s, respectively, comply with the requirements of international standards, and, thus, proved to be viable for the intended application as hydraulic barrier in landfill covering. As for the other composites, although they have not been successful in their intended use, they could be applied for other purposes within a waste landfill, as regularization and/or protection layers. The results obtained demonstrate the technical viability of the intended use of the material.

https://doi.org/10.1590/s1413-415220200073

Preemptive analgesia with ibuprofen increases anesthetic efficacy in children with severe molar hypomineralization: a triple-blind randomized clinical trial
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Vicioni-Marques, Fernanda

; Paula-Silva, Francisco Wanderley Garcia de

; Carvalho, Milena Rodrigues

; Queiroz, Alexandra Mussolino de

; Freitas, Osvaldo de

; Duarte, Maíra Peres Ferreira

; Manton, David John

; Carvalho, Fabrício Kitazono de

Journal of Applied Oral Science

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2022, Volume 30 elocation e20210538

Abstract: En | Text: En | PDF: En

Abstract Molar incisor hypomineralization (MIH) is often accompanied by dental hypersensitivity and difficulty in achieving effective analgesia. Objective: This study evaluated the effectiveness of preemptive analgesia in children with severe MIH, post-eruptive enamel breakdown, and hypersensitivity. Methodology: Ibuprofen (10 mg/kg child weight) or placebo was administered, followed by infiltrative anesthesia and restoration with resin composite. Hypersensitivity was evaluated in five moments. The data were analyzed using the chi-square test, Fisher’s exact test, and t-test. Results: Preemptive analgesia provided benefits for the treatment of severe cases of MIH, with an increase in the effectiveness of infiltrative anesthesia and improved patient comfort during the restorative procedure. Conclusion: Preemptive analgesia has shown efficacy in reducing hypersensitivity during restorative dental procedures, evidencing the significance of this study for patients with MIH and hypersensitivity.

https://doi.org/10.1590/1678-7757-2021-0538

[SciELO Preprints] - IMPACT OF DECISIONS OF THE GOVERNMENT OFFICIALS ON LIFE AND DEATH OF THE POPULATION: COVID-19 IN BRAZIL, JULY 2021. FINAL RESULT OF THE STUDY
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Barreto Júnior, Walter Duarte Kiperstok, Asher Santos, Aychá Freitas Ramacciotti, Dante Eustachio Lucchesi Santos, Fábio S. Souza, Osvaldo Andrade Correia, Raique Lucas de Jesus de Andrade, Ricardo Barretto

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Publication date: 2021-12-16

Abstract: En Es Pt

The Covid-19 pandemic has the entire world in agony, and Brazil is one of the countries being hit the hardest. This is the Fifth and final Article in the series that analyzes a pandemic-related decision made by the Brazilian Ministry of Health in August 2020, when it rejected Pfizer’s proposal to acquire 70 million doses of the Pfizer/BioNTech vaccine. The question we ask is this: 1) Of the Brazilians aged 50 or older who died of Covid-19 in Brazil in July 2021, how many would still be alive if the Ministry of Health had acquired the 70 million doses of the Pfizer/BioNTech vaccine in August 2020? 2) Among people who died of Covid-19 in Brazil, analyzing the conclusive results, these may be alive, if the Ministry of Health of Brazil will have acquired, in August 2020, as 70 million doses of the Pfizer / BioNTech vaccine? This series of studies is mentioned in the Final Report of the Parliamentary Inquiry Commission (CPI) of the Covid-19 Pandemic of the Federal Senate, in Chapter 13, which deals with indictments, specifically in item 13.1, on preventable deaths, and in the Conclusions.

La pandemia de Covid-19 tiene al mundo entero en agonía, y Brasil es uno de los países más afectados. Este es el quinto y último artículo de la serie que analiza una decisión relacionada con una pandemia tomada por el Ministerio de Salud de Brasil en agosto de 2020, cuando rechazó la propuesta de Pfizer de adquirir 70 millones de dosis de la vacuna Pfizer / BioNTech. La pregunta que nos hacemos es la siguiente: 1) De los brasileños de 50 años o más que murieron de Covid-19 en Brasil en julio de 2021, ¿cuántos seguirían con vida si el Ministerio de Salud hubiera adquirido los 70 millones de dosis de Pfizer / BioNTech? vacuna en agosto de 2020? 2) Entre las personas que murieron por Covid-19 en Brasil, analizando los resultados concluyentes, ¿estos pueden estar vivos, si el Ministerio de Salud de Brasil habrá adquirido, en agosto de 2020, como 70 millones de dosis de la vacuna Pfizer / BioNTech? Esta serie de estudios se menciona en el Informe Final de la Comisión de Investigación Parlamentaria (CPI) de la Pandemia Covid-19 del Senado Federal, en el Capítulo 13, que trata de las acusaciones, específicamente en el ítem 13.1, sobre muertes evitables, y en el Conclusiones.

O mundo sofre com a pandemia da Covid-19. O Brasil é um dos países cuja população está sendo mais fortemente atingida. Este é o Quinto e último Artigo da série que analisa uma decisão tomada pelo Ministério da Saúde do Brasil durante a pandemia da Covid-19, que, em agosto de 2020, recusou a proposta da farmacêutica Pfizer para aquisição de 70 milhões de doses da vacina Pfizer/BioNTech. Questiona-se: 1) Entre as pessoas com 50 anos ou mais de idade que faleceram de Covid-19 no Brasil, no mês de julho de 2021, quantas delas poderiam estar vivas, caso o Ministério da Saúde do Brasil tivesse adquirido, em agosto de 2020, as 70 milhões de doses da vacina Pfizer/BioNTech? 2) Entre as pessoas que faleceram de Covid-19 no Brasil, quantas delas poderiam estar vivas, caso o Ministério da Saúde do Brasil tivesse adquirido, em agosto de 2020, as 70 milhões de doses da vacina Pfizer/BioNTech? Essa série de estudos está citada no Relatório Final da Comissão Parlamentar de Inquérito (CPI) da Pandemia da Covid-19 do Senado Federal, no Capítulo 13, que trata dos indiciamentos, especificamente no item 13.1, sobre as mortes evitáveis, e nas Conclusões.

https://doi.org/10.1590/SciELOPreprints.3376

[SciELO Preprints] - IMPACT OF DECISIONS OF THE GOVERNMENT OFFICIALS ON LIFE AND DEATH OF THE POPULATION: COVID-19 IN BRAZIL, JUNE 2021
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Barreto Júnior, Walter Duarte Kiperstok, Asher Santos, Aychá Freitas Ramacciotti, Dante Eustachio Lucchesi Santos, Fábio Souza, Osvaldo Andrade Correia, Raique Lucas de Jesus Andrade, Ricardo Barretto de

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Publication date: 2021-09-10

Abstract: En Es Pt

The Covid-19 pandemic has the entire world in agony, and Brazil is one of the countries being hit the hardest. This is the Fourth Article in the series that analyzes a pandemic-related decision made by the Brazilian Ministry of Health in August 2020, when it rejected Pfizer’s proposal to acquire 70 million doses of the Pfizer/BioNTech vaccine. The question we ask is this: of the Brazilians aged 60 or older who died of Covid-19 in Brazil in June 2021, how many would still be alive if the Ministry of Health had acquired the 70 million doses of the Pfizer/BioNTech vaccine in August 2020?

El mundo sufre la pandemia de Covid-19. Brasil es uno de los países cuya población está siendo más afectada. Este es el cuarto artículo de la serie que analiza una decisión tomada por el Ministerio de Salud de Brasil durante la pandemia Covid-19, que en agosto de 2020 rechazó la propuesta de la farmacéutica Pfizer de adquirir 70 millones de dosis de la vacuna Pfizer / BioNTech. Se cuestiona: entre las personas de 60 años o más que murieron por Covid-19 en Brasil, en junio de 2021, cuántos de ellos podrían haber estado vivos, si el Ministerio de Salud de Brasil lo hubiera adquirido, en agosto de 2020, el 70 millones de dosis de la vacuna Pfizer / BioNTech?

O mundo sofre com a pandemia da Covid-19. O Brasil é um dos países cuja população está sendo mais fortemente atingida. Este é o Quarto Artigo da série que analisa uma decisão tomada pelo Ministério da Saúde do Brasil durante a pandemia da Covid-19, que, em agosto de 2020, recusou a proposta da farmacêutica Pfizer para aquisição de 70 milhões de doses da vacina Pfizer/BioNTech. Questiona-se: entre as pessoas com 60 anos ou mais de idade que faleceram de Covid-19 no Brasil, no mês de junho de 2021, quantas delas poderiam estar vivas, caso o Ministério da Saúde do Brasil tivesse adquirido, em agosto de 2020, as 70 milhões de doses da vacina Pfizer/BioNTech?

https://doi.org/10.1590/SciELOPreprints.2930

Clinical characteristics and evolution of hematological patients and COVID-19 in Argentina: a report from the Argentine Society of Hematology
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Basquiera, Ana L.

; García, Mercedes J

; Martinez Rolón, Juliana

; Olmedo, Julieta

; Laviano, Julia

; Burgos, Rubén

; Caeiro, Gastón

; Remaggi, Guillermina

; Raña, Pablo

; Paoletti, Mariano

; González, Carlos M.

; Fernández, Isolda

; Pavlovsky, Astrid

; Perusini, Maria A.

; Rodriguez, Andrea

; Guanchiale, Luciana

; Carvani, Analia

; Mandrile, Laura

; Figueroa, Flavia

; Vicente Reparaz, Ángeles

; Fragapane Mathus, Patricia N.

; Garate, Gonzalo

; Fauque, María E.

; Kantor, Gustavo

; Cruset, Soledad

; Gonzalez Lorch, Jacqueline S.

; Szelagowski, Milagros

; Giarini, María P.

; Oliveira, Natalia

; García, María C.

; Ventriglia, María V.

; Pereyra, Patricio H.

; Gutierrez, Daniel R.

; Kusminsky, Gustavo

; Troccoli, Josefina

; Freitas, María J.

; Cranco, Santiago

; Del V.Sanchez, Natalia

; Rey, Irene

; Funes, María E.

; Jarchum, Sol

; Freue, Julian

; Miroli, Augusto

; Guerrero, Osvaldo

; López Ares, Lisa

; Campestri, Reinaldo

; Bove, Victor

; Salinas, Graciela N.

; Cabrejo, María

; Milone, Jorge H.

; Zabaljauregui, Soledad

; Gotta, Daniel

; Dupont, Juan Carlos

; Stemmelin, German

Medicina (Buenos Aires)

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aug 2021, Volume 81 N. 4 Pages 536 - 545

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

Abstract Individuals with malignancies and COVID-19 have a lower survival compared with the general population. However, the information about the impact of COVID-19 on the whole hematological population is scarce. We aimed to describe the 30th day overall survival (OS) after COVID-19 infection in pa tients with a hematological disease in Argentina. A completely anonymous survey from the Argentine Society of Hematology was delivered to all the hematologists in Argentina; it started in April 2020. A cut-off to analyze the data was performed in December 2020 and, finally, 419 patients were reported and suitable for the analysis (average age: 58 years, 90% with malignant diseases). After the COVID-19 diagnosis, the 30-day OS for the whole population was 80.2%. From the entire group (419), 101 (24.1%) individuals required intensive care unit admission, where the 30-day OS was 46.6%. Among allogeneic stem cell transplant recipients, the 30-day OS was 70.3%. Factors associated with a low OS were two or more comorbidities, an active hematological disease and history of chemotherapy. In individuals with the three factors, the 30-day OS was 49.6% while the 30-day OS in those without those factors was 100%. Patients with hematological diseases have a higher mortality than the general population. This group represents a challenge and requires careful decision-making of the treatment in order not to compromise the chances of cure.

Resumen El presente estudio tuvo por objetivo primario conocer la mortalidad de pacientes con enfermedad hematológica que presentaron infección por COVID-19 en Argentina. Para ello se difundió una encuesta desde la Sociedad Argentina de Hematología (SAH) entre los hematológos para informar sobre los pacientes con enfermedades hematológicas y diagnóstico de infección por SARS- CoV-2, entre el 19/4/2020, y el 7/12/2020. Se incluyeron individuos de todas las edades con diagnóstico de enfermedad hematológica benigna o maligna e infección por SARS-CoV-2 confirmada por técnica de RT-PCR. Se analizaron 419 pacientes (mediana 58 años; 90% enfermedades malignas). La supervivencia al día 30 fue de 80.2%. La supervivencia fue menor en aquellos que requirieron internación (74.2%), cuidados intensivos (46.6%) y asistencia respiratoria mecánica (36.8%). Entre los trasplantados alogénicos la supervivencia fue 70.3%. Los factores vinculados a la supervivencia global fueron las comorbilidades, el estado de la enfermedad al momento de la infección y el antecedente de quimioterapia. Se pudo establecer un score en el que aquellos que tuvieron un puntaje de 4 alcanzaron una supervivencia del 49.6% al día 30, mientras que la de los pacientes con score 0 fue del 100% a 30 días. En comparación con la población general, los pacientes con enfermedades hematológicas presentan una mayor mortalidad vinculada al COVID-19, motivo por el cual es primordial definir pautas destinadas a disminuir la exposición de los mismos sin comprometer las posibilidades de beneficiarse del tratamiento de la enfermedad de base.

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[SciELO Preprints] - IMPACT OF DECISIONS OF THE GOVERNMENT OFFICIALS ON LIFE AND DEATH OF THE POPULATION: COVID-19 IN BRAZIL, APRIL 2021
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Publication date: 2021-07-22

Abstract: En Es Pt

The Covid-19 pandemic has the entire world in agony, and Brazil is one of the countries being hit the hardest. This is the Third Article in the series that analyzes a pandemic-related decision made by the Brazilian Ministry of Health in August 2020, when it rejected Pfizer’s proposal to acquire 70 million doses of the Pfizer/BioNTech vaccine. The question we ask is this: of the Brazilians aged 60 or older who died of Covid-19 in Brazil in May 2021, how many would still be alive if the Ministry of Health had acquired the 70 million doses of the Pfizer/BioNTech vaccine in August 2020?

El mundo sufre la pandemia de Covid-19. Brasil es uno de los países cuya población está siendo más afectada. Este es el tercer artículo de la serie que analiza una decisión tomada por el Ministerio de Salud de Brasil durante la pandemia Covid-19, que en agosto de 2020 rechazó la propuesta de la farmacéutica Pfizer de adquirir 70 millones de dosis de la vacuna Pfizer / BioNTech. La pregunta es: entre las personas de 60 años o más que murieron por Covid-19 en Brasil, en mayo de 2021, cuántos de ellos podrían haber estado vivos, si el Ministerio de Salud de Brasil lo hubiera adquirido, en agosto de 2020, el 70 millones de dosis de la vacuna Pfizer / BioNTech?

O mundo sofre com a pandemia da Covid-19. O Brasil é um dos países cuja população está sendo mais fortemente atingida. Este é o Terceiro Artigo da série que analisa uma decisão tomada pelo Ministério da Saúde do Brasil durante a pandemia da Covid-19, que, em agosto de 2020, recusou a proposta da farmacêutica Pfizer para aquisição de 70 milhões de doses da vacina Pfizer/BioNTech. Questiona-se: entre as pessoas com 60 anos ou mais de idade que faleceram de Covid-19 no Brasil, no mês de maio de 2021, quantas delas poderiam estar vivas, caso o Ministério da Saúde do Brasil tivesse adquirido, em agosto de 2020, as 70 milhões de doses da vacina Pfizer/BioNTech?

https://doi.org/10.1590/SciELOPreprints.2681

10.

[SciELO Preprints] - IMPACT OF DECISIONS OF THE GOVERNMENT OFFICIALS ON LIFE AND DEATH OF THE POPULATION: COVID-19 IN BRAZIL, APRIL 2021
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Santos, Fábio Kiperstok, Asher Santos, Aychá Freitas Ramacciotti, Dante Eustachio Lucchesi Souza, Osvaldo Andrade Correia, Raique Lucas de Jesus de Andrade, Ricardo Barretto Barreto Júnior, Walter Duarte

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Publication date: 2021-07-07

Abstract: En Pt

The Covid-19 pandemic has the entire world in agony, and Brazil is one of the countries being hit the hardest. This is the S econd Article in the series that analyzes a pandemic-related decision made by the Brazilian Ministry of Health in August 2020, when it rejected Pfizer’s proposal to acquire 70 million doses of the Pfizer/BioNTech vaccine. The question we ask is this: of the Brazilians aged 70 or older who die d of Covid-19 in Brazil in April 2021, how many would still be alive if the Ministry of Health had acquired the 70 million doses of the Pfizer/BioNTech vaccine in August 2020?

O mundo sofre com a pandemia da Covid-19. O Brasil é um dos países cuja população está sendo mais fortemente atingida. Este é o Segundo Artigo da série que analisa uma decisão tomada pelo Ministério da Saúde do Brasil durante uma pandemia da Covid-19, que, em agosto de 2020, recusou a proposta farmacêutica Pfizer para aquisição de 70 milhões de doses da vacina Pfizer / BioNTech . Questiona-se: entre as pessoas com 70 anos ou mais de idade que faleceram de Covid-19 no Brasil, no mês de abril de 2021, quantas delas puderam estar vivas, caso o Ministério da Saúde do Brasil adquiriu adquirido, em agosto de 2020 , como 70 milhões de doses da vacina Pfizer / BioNTech?

https://doi.org/10.1590/SciELOPreprints.2590

11.

[SciELO Preprints] - IMPACT OF DECISIONS OF THE GOVERNMENT OFFICIALS ON LIFE AND DEATH OF THE POPULATION: COVID-19 IN BRAZIL, MARCH 2021
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Santos, Fábio Kiperstok, Asher Santos, Aychá Freitas Ramacciotti, Dante Eustachio Lucchesi Souza, Osvaldo Andrade Correia, Raique Lucas de Jesus Andrade, Ricardo Barretto de Barreto Júnior, Walter Duarte

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Publication date: 2021-05-03

Abstract: En Pt

The Covid-19 pandemic has the entire world in agony, and Brazil is one of the countries being hit the hardest. This article analyzes a pandemic-related decision made by the Brazilian Ministry of Health in August 2020, when it rejected Pfizer’s proposal to acquire 70 million doses of the Pfizer/BioNTech vaccine. The question we ask is this: of the Brazilians aged 80 or older who died of Covid-19 in Brazil in March 2021, how many would still be alive if the Ministry of Health had acquired the 70 million doses of the Pfizer/BioNTech vaccine in August 2020?

O mundo sofre com a pandemia da Covid-19. O Brasil é um dos países cuja população está sendo mais fortemente atingida. Este Artigo analisa uma decisão tomada pelo Ministério da Saúde do Brasil durante a pandemia da Covid-19, que, em agosto de 2020, recusou a proposta da farmacêutica Pfizer para aquisição de 70 milhões de doses da vacina Pfizer/BioNTech. Questiona-se: entre as pessoas com 80 anos ou mais de idade que faleceram de Covid-19 no Brasil, no mês de março de 2021, quantas delas poderiam estar vivas, caso o Ministério da Saúde do Brasil tivesse adquirido, em agosto de 2020, as 70 milhões de doses da vacina Pfizer/BioNTech?

https://doi.org/10.1590/SciELOPreprints.2182

12.

BRAZILIAN GASTRIC CANCER ASSOCIATION GUIDELINES (PART 2): UPDATE ON TREATMENT
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BARCHI, Leandro Cardoso

; RAMOS, Marcus Fernando Kodama Pertille

; DIAS, André Roncon

; FORONES, Nora Manoukian

; CARVALHO, Marineide Prudêncio de

; CASTRO, Osvaldo Antonio Prado

; KASSAB, Paulo

; COSTA-JÚNIOR, Wilson Luiz da

; WESTON, Antônio Carlos

; ZILBERSTEIN, Bruno

; Ferraz, Álvaro Antônio Bandeira

; ZeideCharruf, Amir

; Brandalise, André

; Silva, André Maciel da

; Alves, Barlon

; Marins, Carlos Augusto Martinez

; Malheiros, Carlos Alberto

; Leite, Celso Vieira

; Bresciani, Claudio José Caldas

; Szor, Daniel

; Mucerino, Donato Roberto

; Wohnrath, Durval R.

; JirjossIlias, Elias

; Martins Filho, Euclides Dias

; PinatelLopasso, Fabio

; Coimbra, Felipe José Fernandez

; Felippe, Fernando E. Cruz

; Tomasisch, Flávio Daniel Saavedra

; Takeda, Flavio Roberto

; Ishak, Geraldo

; Laporte, Gustavo Andreazza

; Silva, Herbeth José Toledo

; Cecconello, Ivan

; Rodrigues, Joaquim José Gama

; Grande, José Carlos Del

; Lourenço, Laércio Gomes

; Motta, Leonardo Milhomem da

; Ferraz, Leonardo Rocha

; Moreira, Luis Fernando

; Lopes, Luis Roberto

; Toneto, Marcelo Garcia

; Mester, Marcelo

; Rodrigues, Marco Antônio Gonçalves

; Franciss, Maurice Youssef

; AdamiAndreollo, Nelson

; Corletta, Oly Campos

; Yagi, Osmar Kenji

; Malafaia, Osvaldo

; Assumpção, Paulo Pimentel

; Savassi-Rocha, Paulo Roberto

; Colleoni Neto, Ramiro

; Oliveira, Rodrigo Jose de

; AissarSallun, Rubens Antonio

; Weschenfelder, Rui

; Oliveira, Saint Clair Vieira de

; Abreu, Thiago Boechat de

; Castria, Tiago Biachi de

; Ribeiro Junior, Ulysses

; Barra, Williams

; Freitas Júnior, Wilson Rodrigues de

ABCD. Arquivos Brasileiros de Cirurgia Digestiva (São Paulo)

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2021, Volume 34 N. 1 elocation e1563

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Racional: O II Consenso Brasileiro de Câncer Gástrico da Associação Brasileira de Câncer Gástrico ABCG (Parte 1) foi recentemente publicado. Nesta ocasião inúmeros especialistas que atuam no tratamento desta doença expressaram suas opiniões diante declarações apresentadas. Objetivo: Apresentar as Diretrizes da ABCG (Parte 2) quanto às indicações de tratamento cirúrgico, técnicas operatórias, extensão de ressecção e terapia combinada. Métodos: Para formulação destas diretrizes os autores realizaram extensa e atual revisão referente a cada declaração presente no II Consenso, utilizando as bases Medline/PubMed, Cochrane Library e SciELO, inicialmente com os seguintes descritores: câncer gástrico, gastrectomia, linfadenectomia, terapia combinada. Ainda, cada declaração foi classificada de acordo com o nível de evidência e grau de recomendação. Resultados: Das 43 declarações presentes neste estudo, 11 (25,6%) foram classificadas com nível de evidência A, 20 (46,5%) B e 12 (27,9%) C. Quanto ao grau de recomendação, 18 (41,9%) declarações obtiveram grau de recomendação 1, 14 (32,6%) 2a, 10 (23,3%) 2b e um (2,3%) 3. Conclusão: O complemento das diretrizes aqui presentes possibilita que cirurgiões e oncologistas que atuam no combate ao câncer gástrico possam oferecer o melhor tratamento possível, de acordo com as condições locais disponíveis.

ABSTRACT Background : The II Brazilian Consensus on Gastric Cancer of the Brazilian Gastric Cancer Association BGCA (Part 1) was recently published. On this occasion, countless specialists working in the treatment of this disease expressed their opinion in the face of the statements presented. Aim : To present the BGCA Guidelines (Part 2) regarding indications for surgical treatment, operative techniques, extension of resection and multimodal treatment. Methods: To formulate these guidelines, the authors carried out an extensive and current review regarding each declaration present in the II Consensus, using the Medline/PubMed, Cochrane Library and SciELO databases initially with the following descriptors: gastric cancer, gastrectomy, lymphadenectomy, multimodal treatment. In addition, each statement was classified according to the level of evidence and degree of recommendation. Results : Of the 43 statements present in this study, 11 (25,6%) were classified with level of evidence A, 20 (46,5%) B and 12 (27,9%) C. Regarding the degree of recommendation, 18 (41,9%) statements obtained grade of recommendation 1, 14 (32,6%) 2a, 10 (23,3%) 2b e one (2,3%) 3. Conclusion : The guidelines complement of the guidelines presented here allows surgeons and oncologists who work to combat gastric cancer to offer the best possible treatment, according to the local conditions available.

https://doi.org/10.1590/0102-672020210001e1563 768 downloads

13.

O comum e os desdobramentos na economia solidária a partir do saneamento ecológico
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Machado, Gustavo Carvalhaes Xavier Martins Pontual

; Maciel, Tania Maria de Freitas Barros

; Thiollent, Michel Jean Marie

Saúde e Sociedade

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2021, Volume 30 N. 1 elocation e181188

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Como as condições de saneamento no Brasil são precárias nas áreas rurais, é importante construir ações territorializadas que valorizem a cultura e fortaleçam o bem viver, baseadas na economia solidária para alcançar soluções sustentáveis. Dardot e Laval veem o comum como um contraponto ao atual contexto político e econômico, em que os indivíduos assumem o papel de protagonistas em suas vidas e gerenciam os “comuns” para a comunidade da qual fazem parte. Partindo dessa abordagem, a Fundação Osvaldo Cruz (Fiocruz), por meio do Observatório dos Territórios Saudáveis e Sustentáveis de Bocaina (OTSS), constituiu pesquisa-ação de saneamento ecológico na Comunidade Caiçara da Praia do Sono, em Paraty, com envolvimento da comunidade durante todo o processo e, por meio de avaliação qualitativa, pôde-se entender a relação da comunidade com o comum. Como os construtores locais foram contratados como mobilizadores sociais, os recursos endógenos foram valorizados. Por meio dessa articulação, buscou-se a atuação conjunta junto aos órgãos públicos para fomentar ações que partissem da própria comunidade e políticas públicas inclusivas que colocam a sociedade como protagonista do processo. A partir do conceito de comum e de entrevistas semiestruturadas, esta pesquisa psicossocial tem como objetivo relatar o desdobramento da economia solidária no comum.

Abstract As sanitation conditions in Brazil are precarious in rural areas, it is important to build territorial actions that value culture and strengthen good living based on solidarity economy to achieve sustainable solutions. Dardot and Laval see the “common” as a counterpoint to the current political and economic context, in which individuals assume the role of protagonists in their lives and manage the “commonalities” for their community. In this approach, the Oswaldo Cruz Foundation (Fiocruz), through the Observatory of Sustainable and Healthy Territories of Bocaina (OTSS), constituted an ecological sanitation research in the Caiçara Community of Praia do Sono, in Paraty, with the participation of the community during the whole process and, through a qualitative evaluation, the relationship between the community and the common could be understood. Local builders were hired as social mobilizers, thus valuing endogenous resources. Through this articulation, joint action with public agencies was sought to foster actions that came from the community itself and inclusive public policies that put a society at the center of the process. Supported by the concept of common and by semi-structured interviews, this psychosocial study examines the unfolding of the solidarity economy.

https://doi.org/10.1590/s0104-12902021181188 366 downloads

14.

O comum e os desdobramentos na economia solidária a partir do saneamento ecológico
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Machado, Gustavo Carvalhaes Xavier Martins Pontual

; Maciel, Tania Maria de Freitas Barros

; Thiollent, Michel Jean Marie

Saúde e Sociedade

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2021, Volume 30 N. 1 elocation e181188

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

https://doi.org/10.1590/s0104-12902021181188

15.

Needle-free anesthesia: clinical efficacy of a mucoadhesive patch for atraumatic anesthesia in dental procedures
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ADAMI, Larisse Eduardo

; FREITAS, Osvaldo de

; FIGUEIREDO, Fellipe Augusto Tocchini de

; FERREIRA, Maíra Peres

; MACEDO, Ana Paula

; COUTO, Renê Oliveira do

; PEDRAZZI, Vinicius

Brazilian Oral Research

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2021, Volume 35 elocation e131

Abstract: En | Text: En | PDF: En

Abstract This study showcases the clinical efficacy of mucoadhesive patches designed for the buccal delivery of lidocaine and prilocaine hydrochlorides (1:1, 30 mg/patch). Such patches were developed for needle-free pre-operative local anesthesia in dentistry, aiming at mitigating the use of infiltrative anesthesia for medium-complexity clinical procedures. The patches were manufactured encompassing drug-release, mucoadhesive and backing layers, all prepared through film casting using biocompatible materials. Fifty-eight (n = 58) adult patients (65% women and 35% men) were randomly selected and included in a one-arm open clinical prospective cohort study. The average age of the subjects was of 50 years. The majority (59%) of the subjects, mostly women (82%), reported needle-phobia or anxiety due to dental procedures, which was assessed through a questionnaire approved by the ethical council for human use in research. The patches were positioned in the gingival region of the teeth involved in the procedure (86% on the maxillary and 14% on the mandibular bone). Two anesthetic patches were applied on each patient: one in the vestibular region and another in the palate/lingual portion, and these patches remained attached to the placement sites throughout the procedures. Concerning the dental procedures performed, 40% were cavity preparations and dental restorations of medium cavities; 29% staple facilities; 10% gingival retractions; 9% subgingival scrapings; 3% gingivalplasties; 3% supragingival preparations; 3% occlusal adjustments; and 2% subgingival preparations. In 90% of the cases, it was not necessary to complement with conventional infiltrative local anesthesia during the procedures. Patients did not report any discomfort or side effect during or after the administration of the patches. Among the cases in which there was the need for complementation, 50% were cavity preparations and dental restorations; 33% supragingival preparations; and 17% gingivoplasties. The complementary anesthesia volume was of 0.63 ± 0.23 mL and women corresponded to 83% of the participants who needed such intervention. Furthermore, in most cases, the patch was capable of initiating the anesthesia within a short time frame (5 minutes) and reaching the maximum anesthetic effect within 15 and 25 min, lasting at least 50 min. Undesirable side effects were not reported either 2 h after the administration or within the 6-month follow-up. Therefore, the anesthetic patches developed provide needle-free, painless, safe, and patient/dentist-friendly advances in performing routine medium-complexity dental procedures.

https://doi.org/10.1590/1807-3107bor-2021.vol35.0131 1 downloads

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