Abstract Background: This was a 30-year retrospective cohort study that approximates closely to the natural history of cardiac tumors diagnosed in the fetus, since there was no case of pregnancy interruption Objective: To assess morbidity and mortality in the perinatal period and at long term in fetuses diagnosed with cardiac tumor. Our secondary objective was to assess the evaluating factors of perinatal and postnatal results. Methods: This was a retrospective cohort study with 74 pregnant women with an echocardiographic diagnosis of fetal cardiac tumor at two referral centers between May 1991 and November 2021. A descriptive analysis was performed, and data were expressed as absolute (n) and relative (%) frequencies, median and interquartile range. Fisher's exact test was used to evaluate the association of echocardiographic characteristics and clinical manifestations with perinatal and postnatal results. Global survival was calculated using the Kaplan-Meier method and the curves were compared by the log-rank test. The time of follow-up, calculated in months, corresponded to the time elapsed from hospital discharge to current status (survived/ censoring or death). The level of significance was set at 5% (p<0.05). Results: Rhabdomyoma is the most common type of cardiac tumor (85%), with a high morbidity (79.3%) and overall mortality of 17.4%. The presence of fetal hydrops was a predictor of death. Conclusion: The presence of fetal hydrops had an impact on mortality, and hence is an important factor in counselling and determining the prognosis. Most deaths occurred before hospital discharge. Background 30year year 30 fetus Objective results Methods 7 199 2021 performed n (n % (% frequencies range Fishers Fisher s KaplanMeier Kaplan Meier logrank log rank followup, followup follow up, up follow-up months survived/ survived (survived death . death) 5 p<0.05. p005 p p<0.05 0 05 (p<0.05) Results 85%, 85 85% , (85%) 79.3% 793 79 3 (79.3% 174 17 4 17.4% Conclusion prognosis 19 202 ( p00 p<0.0 (p<0.05 8 (85% 79.3 (79.3 1 17.4 20 p0 p<0. (p<0.0 (85 79. (79. 17. 2 p<0 (p<0. (8 (79 p< (p<0 (7 (p< (p

Resumo Fundamento: Seguimento de coorte retrospectiva de 30 anos que se aproxima da história natural dos tumores cardíacos diagnosticados no feto uma vez que nenhum caso foi submetido à interrupção da gestação. Objetivo: Avaliar a morbidade e mortalidade perinatal e em longo prazo em fetos com diagnóstico de tumor cardíaco. Como objetivo secundário avaliar os fatores que influenciaram os resultados perinatais e pós-natais. Método: Estudo de coorte retrospectiva envolvendo 74 gestantes com diagnóstico ecocardiográfico fetal de tumor cardíaco acompanhadas em dois serviços de referência no período de maio de 1991 a novembro de 2021. Foi realizada análise descritiva dos dados por meio de frequências absolutas (n) e relativas (%), mediana e intervalos interquartis. Para avaliar a associação entre as características ecocardiográficas e as manifestações clínicas com os resultados perinatais e pós-natais, foi aplicado o teste exato de Fisher. O cálculo da sobrevida global foi realizado pelo método de Kaplan-Meier e a comparação de curvas pelo teste de log-rank. O tempo de seguimento, calculado em meses, foi definido a partir da data de alta do hospital à data do status atual (vivo/censura ou óbito). O nível de significância considerado foi de 5% (p<0,05). Resultados: o rabdomioma é o tipo mais frequente (85%) de tumor cardíaco; apresenta alta morbidade (79,3%) e mortalidade geral de 17,4%; a presença de hidropisia fetal preditiva de óbito. Conclusão: A presença de hidropisia fetal teve impacto na mortalidade, sendo fator importante para aconselhamento e estabelecimento de prognóstico. A maioria dos óbitos ocorrem antes da alta hospitalar. Fundamento 3 gestação Objetivo pósnatais. pósnatais pós natais. natais pós-natais Método 7 199 2021 n (n %, % , (%) interquartis pósnatais, natais, Fisher KaplanMeier Kaplan Meier logrank. logrank log rank. rank log-rank seguimento meses vivo/censura vivocensura vivo censura óbito . óbito) 5 p<0,05. p005 p p<0,05 0 05 (p<0,05) Resultados 85% 85 (85% 79,3% 793 79 (79,3% 17,4% 174 17 4 Conclusão prognóstico hospitalar 19 202 (% p00 p<0,0 (p<0,05 8 (85 79,3 (79,3 17,4 1 20 ( p0 p<0, (p<0,0 (8 79, (79, 17, 2 p<0 (p<0, (79 p< (p<0 (7 (p< (p

Abstract Introduction Pregnancy and diabetes mellitus promote several musculoskeletal changes predisposing this population to complaints of Lower Back (LB) and Pelvic Pain (PP). Objective To assess the frequency of LB and PP and associated factors in type 1 Diabetic (DM1) pregnant women. Method: An observational analytical cross-sectional study. Thirty-six pregnant women with DM1 were evaluated through a postural assessment with a focus on pelvic positioning and what patients reported. The associated factors were assessed using the State-Trait Anxiety Inventory (STAI), the International Consultation on Incontinence Questionnaire Short Form (ICIQ-SF), and the Female Sexual Function Index (FSFI). Results The frequency of LB and PP was 55.6 % and 30.6 %, respectively. The presence of anxiety was not associated with a higher prevalence of pain. The incidence of sexual dysfunctions was higher in the GD. DM1 duration had a mean of 14.9 years (± 8.2 SD) in the GD and 9.0 years (± 6.9 SD) in the GSD, which was statistically significant (p ≤ 0.050). In the multiple binary regression analysis for the occurrence of pain, the independent factor was DM1 duration ≥ 17 years (OR = 11.2; 95 % CI = 1.02‒124.75). The association between DM1 duration ≥ 17 years and being overweight showed a probability of 95 % for the studied population in the analysis of the probabilities of occurrence of the pain event. Conclusion There was a high frequency of LB and PP related to pregnancy in DM1 pregnant women in the second trimester of pregnancy. The incidence of sexual dysfunction and DM1 duration ≥ 17 years increases the chance that DM1 pregnant women will experience pain. There was no association between anxiety. urinary incontinence and pain in DM1 pregnant women. (LB PP. . (PP) DM (DM1 Method crosssectional cross sectional study Thirtysix Thirty six reported StateTrait State Trait STAI, STAI , (STAI) ICIQSF, ICIQSF ICIQ SF (ICIQ-SF) FSFI. FSFI (FSFI) 556 55 6 55. 306 30 30. respectively 149 14 9 14. ± ( 82 8 2 8. SD 90 0 9. 69 6. GSD p 0.050. 0050 0.050 050 0.050) OR 11.2 112 11 1.02‒124.75. 10212475 1.02‒124.75 02 124 75 1.02‒124.75) event (PP (DM (STAI (ICIQ-SF (FSFI 5 3 005 0.05 05 11. 1021247 1.02‒124.7 12 7 00 0.0 102124 1.02‒124. 0. 10212 1.02‒124 1021 1.02‒12 102 1.02‒1 10 1.02‒ 1.02 1.0 1.

ABSTRACT Objective: To present the methodology used in the development of two products for maternal health surveillance and its determinants and discuss their possible uses. Methods: Based on a theoretical model of the determinants of maternal death and databases of Brazilian health information systems, two free products were developed: an interactive panel “surveillance of maternal health” and an educational material “Aparecida: a story about the vulnerability of Brazilian women to maternal death”, both available on the website of the Brazilian Obstetric Observatory. Results: More than 30 indicators were calculated for the period 2012-2020, containing information on socioeconomic conditions and access to health services, reproductive planning, prenatal care, delivery care, conditions of birth and maternal mortality and morbidity. The indicators related to severe maternal morbidity in public hospitalizations stand out, calculated for the first time for the country. The panel allows analysis by municipality or aggregated by health region, state, macro-region and country; historical series analysis; and comparisons across locations and with benchmarks. Information quality data are presented and discussed in an integrated manner with the indicators. In the educational material, visualizations with national and international data are presented, aiming to help in the understanding of the determinants of maternal death and facilitate the interpretation of the indicators. Conclusion: It is expected that the two products have the potential to expand epidemiological surveillance of maternal health and its determinants, contributing to the formulation of health policies and actions that promote women’s health and reduce maternal mortality. Objective uses Methods systems developed Aparecida “Aparecida death, , death” Observatory Results 3 20122020, 20122020 2012 2020, 2020 2012-2020 services planning care out country region state macroregion macro benchmarks Conclusion womens s 2012202 201 202 2012-202 201220 20 2012-20 20122 2 2012-2 2012-

RESUME Objetivo: Apresentar a metodologia utilizada no desenvolvimento de dois produtos para a vigilância da saúde materna e seus determinantes e discutir as suas possíveis utilizações. Métodos: A partir de modelo teórico dos determinantes do óbito materno e bases de dados dos sistemas de informação em saúde brasileiros, foram desenvolvidos dois produtos gratuitos: um painel interativo denominado “Vigilância da saúde materna” e um material educativo chamado “Aparecida: uma história sobre a vulnerabilidade da mulher brasileira à morte materna”, ambos disponíveis no site do Observatório Obstétrico Brasileiro. Resultados: Foram calculados mais de 30 indicadores para o período 2012-2020, contendo informações sobre condições socioeconômicas e de acesso a serviços de saúde, planejamento reprodutivo, assistência pré-natal, assistência ao parto, condições de nascimento e mortalidade e morbidade materna. Destacam-se os indicadores relacionados à morbidade materna grave em internações públicas, calculados pela primeira vez para o país. O painel permite análises por município ou agregadas por região de saúde, unidade da federação, macrorregião e país; análises de série histórica; e comparações entre localidades e com padrões de referência. Dados de qualidade da informação são apresentados e discutidos de forma integrada aos indicadores. No material educativo, visualizações com dados nacionais e internacionais são apresentadas, visando auxiliar na compreensão dos determinantes do óbito materno e facilitar a interpretação dos indicadores. Conclusão: Espera-se que os produtos tenham o potencial de ampliar a vigilância epidemiológica da saúde materna e seus determinantes, contribuindo para a formulação de políticas e ações de saúde que promovam a saúde das mulheres e reduzam a mortalidade materna. Objetivo utilizações Métodos brasileiros gratuitos Vigilância Aparecida “Aparecida materna, , Brasileiro Resultados 3 20122020, 20122020 2012 2020, 2020 2012-2020 reprodutivo prénatal, prénatal pré natal, natal pré-natal parto Destacamse Destacam se públicas país federação histórica referência apresentadas Conclusão Esperase Espera 2012202 201 202 2012-202 201220 20 2012-20 20122 2 2012-2 2012-

Abstract Background: Myelomeningocele (MMC) is a neural tube defect disease. Antenatal repair of fetal MMC is an alternative to postnatal repair. Many agents can be used as tocolytics during the in utero fetal repair such as β2-agonists and oxytocin receptor antagonists, with possible maternal and fetal repercussions. This study aims to compare maternal arterial blood gas analysis between terbutaline or atosiban, as tocolytic agents, during intrauterine MMC repair. Methods: Retrospective cohort study. Patients were divided into two groups depending on the main tocolytic agent used during intrauterine MMC repair: atosiban (16) or terbutaline (9). Maternal arterial blood gas samples were analyzed on three moments: post induction (baseline, before the start of tocolysis), before extubation, and two hours after the end of the surgery. Results: Twenty-five patients were included and assessed. Before extubation, the terbutaline group showed lower arterial pH (7.347 ± 0.05 vs. 7.396 ± 0.02 for atosiban, p = 0.006) and higher arterial lactate (28.33 ± 12.76 mg.dL–1 vs. 13.06 ± 6.35 mg.dL–1, for atosiban, p = 0.001) levels. Conclusions: Patients who received terbutaline had more acidosis and higher levels of lactate, compared to those who received atosiban, during intrauterine fetal MMC repair. Background (MMC disease β2agonists βagonists β2 agonists β antagonists repercussions Methods 16 (16 9. 9 . (9) moments baseline, baseline (baseline tocolysis, tocolysis , tocolysis) extubation surgery Results Twentyfive Twenty five assessed 7.347 7347 7 347 (7.34 005 0 05 0.0 vs 7396 396 7.39 002 02 0.006 0006 006 28.33 2833 28 33 (28.3 1276 12 76 12.7 mgdL1 mgdL mg dL 1 mg.dL– 1306 13 06 13.0 635 6 35 6.3 0.001 0001 001 Conclusions (1 (9 7.34 734 34 (7.3 00 0. 739 39 7.3 0.00 000 28.3 283 2 3 (28. 127 12. mg.dL 130 13. 63 6. ( 73 (7. 7. 28. (28 (7 (2

ABSTRACT Objective: To present the methodology used in the development of two products for maternal health surveillance and its determinants and discuss their possible uses. Methods: Based on a theoretical model of the determinants of maternal death and databases of Brazilian health information systems, two free products were developed: an interactive panel “surveillance of maternal health” and an educational material “Aparecida: a story about the vulnerability of Brazilian women to maternal death”, both available on the website of the Brazilian Obstetric Observatory. Results: More than 30 indicators were calculated for the period 2012-2020, containing information on socioeconomic conditions and access to health services, reproductive planning, prenatal care, delivery care, conditions of birth and maternal mortality and morbidity. The indicators related to severe maternal morbidity in public hospitalizations stand out, calculated for the first time for the country. The panel allows analysis by municipality or aggregated by health region, state, macro-region and country; historical series analysis; and comparisons across locations and with benchmarks. Information quality data are presented and discussed in an integrated manner with the indicators. In the educational material, visualizations with national and international data are presented, aiming to help in the understanding of the determinants of maternal death and facilitate the interpretation of the indicators. Conclusion: It is expected that the two products have the potential to expand epidemiological surveillance of maternal health and its determinants, contributing to the formulation of health policies and actions that promote women’s health and reduce maternal mortality.

RESUME Objetivo: Apresentar a metodologia utilizada no desenvolvimento de dois produtos para a vigilância da saúde materna e seus determinantes e discutir as suas possíveis utilizações. Métodos: A partir de modelo teórico dos determinantes do óbito materno e bases de dados dos sistemas de informação em saúde brasileiros, foram desenvolvidos dois produtos gratuitos: um painel interativo denominado “Vigilância da saúde materna” e um material educativo chamado “Aparecida: uma história sobre a vulnerabilidade da mulher brasileira à morte materna”, ambos disponíveis no site do Observatório Obstétrico Brasileiro. Resultados: Foram calculados mais de 30 indicadores para o período 2012-2020, contendo informações sobre condições socioeconômicas e de acesso a serviços de saúde, planejamento reprodutivo, assistência pré-natal, assistência ao parto, condições de nascimento e mortalidade e morbidade materna. Destacam-se os indicadores relacionados à morbidade materna grave em internações públicas, calculados pela primeira vez para o país. O painel permite análises por município ou agregadas por região de saúde, unidade da federação, macrorregião e país; análises de série histórica; e comparações entre localidades e com padrões de referência. Dados de qualidade da informação são apresentados e discutidos de forma integrada aos indicadores. No material educativo, visualizações com dados nacionais e internacionais são apresentadas, visando auxiliar na compreensão dos determinantes do óbito materno e facilitar a interpretação dos indicadores. Conclusão: Espera-se que os produtos tenham o potencial de ampliar a vigilância epidemiológica da saúde materna e seus determinantes, contribuindo para a formulação de políticas e ações de saúde que promovam a saúde das mulheres e reduzam a mortalidade materna.

ABSTRACT Objective: The aim of the study was to assess the impact of the Gamma coronavirus disease 2019 (COVID-19) variant on pregnant and postpartum women with Cardiovascular Disease (CVD). Methods: The Influenza Epidemiological Surveillance System database (SIVEP-Gripe), a compulsory notification system for cases of Severe Acute Respiratory Syndrome (SARS), was investigated for notified cases of pregnant and postpartum women with reported CVD and SARS due to COVID-19 between February 16, 2020 and May 1, 2021 (when vaccination began), was investigated. In this retrospective cohort, two groups were formed based on symptom onset date, according to the predominance of the variants: original (group 2020) and Gamma (group 2021). Cases with missing information on the presence or absence of CVD were excluded. The comparative analysis was controlled for confounding variables. Results: Among 703 COVID-19 cases notified with CVD (406 patients in 2020 and 297 patients in 2021), compared to 2020, cases in 2021 had more respiratory symptoms (90.6 % vs. 80.1 %, p < 0.001), greater ventilatory support need (75.3 % vs. 53.9 %, p < 0.001), more ICU admission (46.6 % vs. 34.3 %, p = 0.002), longer duration (20.59 ± 14.47 vs. 16.52 ± 12.98 days, p < 0.001), higher mortality (25.6 % vs. 15.5 %, p < 0.001), with more than two-times mortality likelihood in the third trimester (adjusted OR = 2.41, 95 % CI 1.50–3.88, p < 0.001) or puerperium periods (adjusted_OR = 2.15, 95 % CI 1.34-3.44, p = 0.001). Conclusions: In Brazil, pregnant and postpartum women with CVDs in the Gamma variant phase have higher morbidity and mortality than those affected by the original variant of Coronavirus-19. Objective 201 COVID19 COVID 19 (COVID-19 CVD. . (CVD) Methods SIVEPGripe, SIVEPGripe SIVEP Gripe , (SIVEP-Gripe) SARS, (SARS) COVID-1 16 202 1 when began, began began) cohort date variants group 2021. 2021) excluded variables Results 70 406 (40 29 2021, 90.6 906 90 6 (90. vs 801 80 80. 0.001, 0001 0.001 0 001 75.3 753 75 3 (75. 539 53 9 53. 46.6 466 46 (46. 343 34 34. 0.002, 0002 0.002 002 0.002) 20.59 2059 20 59 (20.5 1447 14 47 14.4 1652 52 16.5 1298 12 98 12.9 days 25.6 256 25 (25. 155 15 5 15. twotimes times adjusted 241 2 41 2.41 150388 50 88 1.50–3.88 adjusted_OR adjustedOR 215 2.15 1.343.44, 134344 1.34 3.44, 44 1.34-3.44 0.001. Conclusions Brazil Coronavirus19. Coronavirus19 Coronavirus 19. Coronavirus-19 COVID1 (COVID-1 (CVD (SIVEP-Gripe (SARS COVID- 7 40 (4 90. (90 8 000 0.00 00 75. (75 46. 4 (46 20.5 205 (20. 144 14. 165 16. 129 12. 25. (25 24 2.4 15038 1.50–3.8 21 2.1 1.343.44 13434 134 1.3 344 3.44 1.34-3.4 Coronavirus1 Coronavirus-1 (COVID- ( (9 0.0 (7 20. (20 (2 2. 1503 1.50–3. 1.343.4 1343 13 1. 3.4 1.34-3. Coronavirus- (COVID 0. 150 1.50–3 1.343. 3. 1.34-3 1.50– 1.343 1.34- 1.50 1.5

Abstract Objective: This study aimed to evaluate the Neuropsychomotor Development (NPMD) of newborns exposed to SARS-CoV-2 in the perinatal period using the Bayley III scale at 6 months of age. Methods: Childcare appointments were scheduled for the included newborns in the study. During the 6-month consultation, the Screening Test for Bayley III Scale and, based on it, children were classified as “low risk”, “moderate risk” or “high risk” in the domains: of cognitive, receptive language, expressive language, fine motor, and gross motor. Those classified as “moderate risk”; or “high risk” received guidance about NPMD stimuli and were instructed to maintain follow-up. Results: Only 13 (37.1 %) of the newborns were classified as low risk in receptive language and 18 (51.4 %) in gross motor skills, with the domains most affected. Prematurity was a risk for cognitive incompetence (moderate risk/high-risk classification) (coefficient: 1.89, Odds Ratio = 6.7, 95 % CI 1.3‒35, p = 0.02). Lower birth weight that 2.500g had a similar effect on cognitive incompetence (coefficient: 1.9, Odds Ratio = 6.2, 95 % CI 1.2‒32.2, p = 0.02). Exclusive breastfeeding at hospital discharge (n = 8) was protective for incompetence (high risk/moderate risk) in the language domain (coefficient -2.14, OR = 0.12, 95 % CI 0.02‒0.71, p = 0.02). Conclusions: The children included in the study must be monitored and their development monitored in order to clarify whether there is a relationship between the delay in NPMD and perinatal exposure to COVID-19, as delays were observed in these preliminary results. Objective (NPMD SARSCoV2 SARSCoV SARS CoV 2 SARS-CoV- age Methods 6month month consultation it risk, , moderate high followup. followup follow up. up follow-up Results 1 37.1 371 37 (37. 51.4 514 51 4 (51. skills affected risk/highrisk riskhighrisk risk/high classification coefficient 189 89 1.89 67 7 6.7 9 1335 3 35 1.3‒35 0.02. 002 0.02 . 0 02 0.02) 2500g g 500g 19 1.9 62 6.2 12322 32 1.2‒32.2 n 8 riskmoderate 2.14, 214 14 -2.14 012 12 0.12 002071 71 0.02‒0.71 Conclusions COVID19, COVID19 COVID 19, COVID-19 results SARS-CoV 37. (37 51. 5 (51 highrisk riskhigh 1.8 6. 133 1.3‒3 00 0.0 1. 1232 1.2‒32. 2.14 21 -2.1 01 0.1 00207 0.02‒0.7 COVID1 COVID-1 (3 (5 1.3‒ 0. 123 1.2‒32 2.1 -2. 0020 0.02‒0. COVID- ( 1.3 1.2‒3 2. -2 0.02‒0 1.2‒ - 0.02‒ 1.2

Abstract Objective To analyze the impact of the COVID-19 pandemic on the residency of gynecology and obstetrics in São Paulo. Methods Cross-sectional study developed by representatives of residents of the Association of Gynecology and Obstetrics of the State of São Paulo (SOGESP, in the Portuguese acronym). Data were collected from questionnaires applied to gynecology and obstetrics residents registered on the SOGESP website in February 2022. The interviewees answered about the repercussions of the pandemic on medical residency and whether they had technical and psychological support during the period. Results A total of 247 questionnaires were collected from residents of gynecology and obstetrics. The residents had an age of 28.3 ± 3 years old, and most of them were female (88.4%). The displacement to COVID care was reported by 62.34% of the students, but only 35.6% reported completely adequate personal protective equipment and only 7.7% reported complete theoretical and technical instruction to support these patients. Almost all of the interviewees stated that the gynecology sector was the most affected. The majority of the interviewees considered that the second-year residents had the greatest loss, and more than half of the residents in the 1st and 2nd year said they wished to give up their residency during the pandemic. More than 80% of the residents reported online theoretical classes and/or presentation of articles, reinforcing the fact that virtual activities gained a greater space within the medical residency. Conclusion The pandemic impacted the residency in greater proportion in outpatient clinics and gynecological surgeries, also interfering with the physician's desire to continue with the program. COVID19 19 COVID-1 Crosssectional Cross sectional SOGESP, (SOGESP acronym. acronym . acronym) 2022 period 24 283 28 28. old 88.4%. 884 88.4% 88 4 (88.4%) 6234 62 34 62.34 students 356 35 6 35.6 77 7 7.7 patients affected secondyear second loss st nd 80 andor or articles surgeries physicians physician s program COVID1 1 COVID- 202 2 88.4 8 (88.4% 623 62.3 35. 7. 20 88. (88.4 62. (88. (88 (8 (

Resumo Objetivo Analisar o impacto pandemia de COVID-19 sobre a residência de ginecologia e obstetrícia do Estado de São Paulo. Métodos Estudo transversal desenvolvido por representantes dos residentes da Associação de Ginecologia e Obstetrícia do Estado de São Paulo (SOGESP). Foram coletados dados de questionários aplicados aos residentes de ginecologia e obstetrícia cadastrados no site da SOGESP em fevereiro de 2022. Os entrevistados responderam sobre repercussões da pandemia sobre a residência médica e se tiveram suporte técnico e psicológico durante o período. Resultados Foram levantados 247 questionários de residentes de ginecologia e obstetrícia. Os residentes apresentaram idade de 28,3 ± 3 anos, sendo a maioria do sexo feminino (88,4%). O deslocamento para “covidários” foi referido por 62,34% dos avaliados, porém somente 35,6% referiram equipamento de proteção individual completamente adequado e apenas 7,7% referiram instrução completa teórica e técnica para o suporte destes pacientes. Quase a totalidade dos entrevistados afirmou que o setor de ginecologia foi o mais afetado. A maioria dos entrevistados considerou que o os residentes do segundo ano foram os que tiveram maior prejuízo, sendo que mais da metade dos residentes do 1° e 2° ano afirmou ter desejado desistir da residência durante a pandemia. Mais de 80% dos residentes referiram aulas teóricas e/ou apresentação de artigos online, reforçando o fato de que as atividades virtuais ganharam um espaço maior dentro da residência médica. Conclusão A pandemia impactou nas residências em maior proporção nos ambulatórios e cirurgias ginecológicas, interferindo também sobre o desejo do médico de seguir com o programa. COVID19 COVID 19 COVID-1 SOGESP. . (SOGESP) 2022 período 24 283 28 28, anos 88,4%. 884 88,4% 88 4 (88,4%) covidários “covidários 6234 62 34 62,34 avaliados 356 35 6 35,6 77 7 7,7 pacientes afetado prejuízo 1 2 80 eou ou online ginecológicas programa COVID1 COVID- (SOGESP 202 88,4 8 (88,4% 623 62,3 35, 7, 20 88, (88,4 62, (88, (88 (8 (

ABSTRACT Objectives: To analyze the perinatal outcomes of Perinatally acquired HIV Infection (PHIV) in pregnant women. Method: This retrospective cohort study included singleton pregnancies in Women Living with HIV (WLH) between 2006 and 2019. Patient charts were revised, and maternal characteristics, type of HIV infection (perinatal vs. behavioral), Antiretroviral Therapy (ART) exposure, and obstetric and neonatal outcomes were assessed. The HIV-related aspects considered were: Viral Load (VL), CD4+ cell count, opportunistic infections, and genotype testing. Laboratory analyses were performed at baseline (first appointment) and 34 weeks of gestation. Results: There were 186 WLH pregnancies, and 54 (29%) patients had PHIV. Patients with PHIV were younger (p < 0.001), had less frequently stable partnerships (p < 0.001), had more commonly serodiscordant partners (p < 0.001), had a longer time on ART (p < 0.001), and had lower rates of undetectable VL at baseline (p = 0.046) and at 34 weeks of gestation (p < 0.001). No association was observed between PHIV and adverse perinatal outcomes. Among patients with PHIV, third trimester anemia was associated with preterm birth (p = 0.039). Genotype testing was available only for 11 patients with PHIV, who presented multiple mutations related to ART resistance. Conclusions: PHIV did not seem to increase the risk of adverse perinatal outcomes. However, PHIV pregnancies have a higher risk of viral suppression failure and exposure to complex ARTs. Objectives (PHIV women Method (WLH 200 2019 revised characteristics vs behavioral, behavioral , behavioral) (ART assessed HIVrelated VL, (VL) CD4 CD count infections first appointment 3 Results 18 5 29% 29 (29% p 0.001, 0001 0.001 0 001 0.001) 0.046 0046 046 0.001. . 0.039. 0039 0.039 039 0.039) 1 resistance Conclusions However ARTs 20 201 (VL 2 (29 000 0.00 00 0.04 004 04 003 0.03 03 (2 0.0 ( 0.

Abstract Introduction Limited data are available on pregnant women with COVID-19 and their neonates. Objective This study aimed to describe clinical characteristics and evolution from birth to discharge of a retrospective cohort of 71 neonates, with one set of twins, born to women with COVID-19 diagnosed at the end of pregnancy. The authors included all newborns admitted into a neonatal unit of a tertiary hospital in Brazil, between March 2020 and March 2021, whose unvaccinated mothers had COVID-19 symptoms and RT-PCR (Real-Time Polymerase Chain Reaction) for SARS-CoV-2 positive within fourteen days prior to delivery. Newborns to mothers with COVID-19 symptoms and negative tests for SARS-CoV-2 were excluded. Results The main route of birth delivery was cesarean, corresponding to 60 pregnant women (84.5%). The foremost indications for cesarean were pregnant with critical disease (24.6%) and acute fetal distress (20.3%). The mean birth weight was 2452 g (865‒3870 g) and the mean gestational age was 345/7weeks (25‒40 weeks). There were 45 premature newborns (63.3%), of which 21 newborns (29.5%) were less than 32 weeks of gestational age. RT-PCR for SARS-CoV-2 on oropharyngeal swabs was positive in 2 newborns (2.8%) and negative in the other 69 newborns (97.2%). Most newborns (51.4%) needed respiratory support. Therapeutic interventions during hospitalization were inotropic drugs (9.9%), antibiotics (22.8%), parenteral nutrition (26.8%), and phototherapy (46.5%). Conclusion Maternal COVID-19 diagnosticated close to delivery has an impact on the first days of neonatal life. COVID19 COVID 19 COVID-1 neonates 7 twins pregnancy Brazil 202 2021 RTPCR RT PCR RealTime Real Time Reaction SARSCoV2 SARSCoV SARS CoV SARS-CoV- excluded 6 84.5%. 845 84.5% . 84 5 (84.5%) 24.6% 246 24 (24.6% 20.3%. 203 20.3% 20 3 (20.3%) 245 865‒3870 8653870 865 3870 (865‒387 3457weeks 345 7weeks 25‒40 2540 25 40 (25‒4 weeks. weeks) 4 63.3%, 633 63.3% , 63 (63.3%) 29.5% 295 29 (29.5% 2.8% 28 8 (2.8% 97.2%. 972 97.2% 97 (97.2%) 51.4% 514 51 (51.4% support 9.9%, 99 9.9% 9 (9.9%) 22.8%, 228 22.8% 22 (22.8%) 26.8%, 268 26.8% 26 (26.8%) 46.5%. 465 46.5% 46 (46.5%) life COVID1 1 COVID- SARS-CoV 84.5 (84.5% 24.6 (24.6 20.3 (20.3% 865‒387 865387 86 387 (865‒38 34 25‒4 254 (25‒ 63.3 (63.3% 29.5 (29.5 2.8 (2.8 97.2 (97.2% 51.4 (51.4 9.9 (9.9% 22.8 (22.8% 26.8 (26.8% 46.5 (46.5% 84. (84.5 24. (24. 20. (20.3 865‒38 86538 38 (865‒3 25‒ (25 63. (63.3 29. (29. 2. (2. 97. (97.2 51. (51. 9. (9.9 22. (22.8 26. (26.8 46. (46.5 (84. (24 (20. 865‒3 8653 (865‒ (2 (63. (29 (97. (51 (9. (22. (26. (46. (84 (20 865‒ (865 ( (63 (97 (5 (9 (22 (26 (46 (8 (86 (6 (4

Abstract Objective: To identify risk factors for Oxygen (O2) needs in pregnant and postpartum women with COVID-19. Methods: Prospective cohort involving pregnant women hospitalized with COVID-19 from April to October 2020. The oxygen need was analyzed regarding risk factors: demographic characteristics, clinical and laboratory parameters at hospital admission, and chest Computer Tomography (CT) findings. Poisson univariate analysis was used to estimate the Relative Risk (RR) and 95% Confidence Intervals. Results: 145 patients, 80 who used and 65 who did not use O2, were included. Body mass index ≥ 30, smoking, and chronic hypertension increased the risk of O2 need by 1.86 (95% CI 1.10–3.21), 1.57 (95% CI 1.16‒2.12), and 1.46 (95% CI 1.09‒1.95), respectively. Patients who were hospitalized for COVID-19 and for obstetric reasons had 8.24 (95% CI 2.8‒24.29) and 3.44 (95% CI 1.05‒11.31) times more use of O2 than those admitted for childbirth and abortion. Respiratory rate ≥ 24 breaths/min and O2 saturation < 95% presented RR for O2 requirements of 2.55 (1.82‒3.56) and 1.68 (95% CI 1.27-2.20), respectively. Ground Glass (GG) < 50% and with GG ≥ 50%, the risk of O2 use were respectively 3.41-fold and 5.33-fold higher than in patients who haven’t viral pneumonia on CT. The combination of C-reactive protein ≥ 21 mg/L, hemoglobin < 11.0 g/dL, and lymphopenia < 1500 mm3 on hospital admission increased the risk of O2 use by 4.97-times. Conclusions: In obstetric patients, clinical history, laboratory, clinical and radiological parameters at admission were identified as a risk for O2 need, selecting the population with the greatest chance of worsening. HIGHLIGHTS In unvaccinated pregnant and postpartum women, any need for oxygen supply increases the risk of invasive ventilation. Obesity, smoking and chronic arterial hypertension proved to be risk factors for the use of oxygen in pregnant and postpartum women with COVID-19. The combination of C-reactive protein ≥ 21 mg/L, hemoglobin < 11.0 g/dL, and lymphopenia < 1500 mm on hospital admission and the presence of ground glass ≥ 50% in computer tomography increased the risk of O2 use by 4.97 and 5.33 times respectively in pregnant and postpartum women with COVID-19.

Abstract Objectives: To determine the incidence and risk of adverse obstetric and neonatal outcomes according to SARS-CoV-2 infection severity in pregnant women. Method: Open prospective study of pregnant women tested for SARS-CoV-2 by serological and molecular assays during pregnancy or delivery in two hospitals in Sao Paulo, Brazil from April 12, 2020, to February 28, 2021. Five groups were considered for analysis: C0, negative COVID-19 results and no COVID-19 symptoms; C1, positive COVID-19 results, and no symptoms; C2, positive COVID-19 results with mild symptoms; C3, positive COVID-19 results with moderate symptoms; and C4, positive COVID-19 results with severe symptoms. The association between obstetric and neonatal outcomes and COVID-19 severity was determined using multivariate analysis. Results: 734 eligible pregnant women were enrolled as follows: C0 (n = 357), C1 (n = 127), C2 (n = 174), C3 (n = 37), and C4 (n = 39). The following pregnancy and neonatal outcomes were associated with severe COVID-19: oligohydramnios (adjusted Odds Ratio [aOR] = 6.18; 95% CI 1.87‒20.39), fetal distress (aOR = 4.01; 95% Confidence Interval [CI] 1.84‒8.75), preterm birth (aOR = 5.51; 95% CI 1.47‒20.61), longer hospital stay (aOR = 1.66; 95% CI 1.36‒2.02), and admission to the neonatal intensive care unit (aOR = 19.36; 95% CI, 5.86‒63.99). All maternal (n = 6, 15.4%, p < 0.001) and neonatal (n = 5, 12.5%, p < 0.001) deaths and most fetal deaths (n = 4, 9.8%, p < 0.001) occurred in C4 group. Moderate COVID-19 was associated with oligohydramnios (aOR = 6.23; 95% CI 1.93‒20.13) and preterm birth (aOR = 3.60; 95% CI 1.45‒9.27). Mild COVID-19 was associated with oligohydramnios (aOR=3.77; 95% CI 1.56‒9.07). Conclusion: Adverse pregnancy and neonatal outcomes were associated with maternal symptomatic COVID-19 status, and risk increased with disease severity. HIGHLIGHTS COVID-19 increases the rates of adverse pregnancy and neonatal outcomes. Serious cases are associated with oligohydramnios, fetal distress, prematurity, neonatal ICU admission, maternal and neonatal deaths. The maternal clinical status dictates obstetric and neonatal outcomes.

Abstract Purpose The authors aim to carry out an investigation on the impact of cervical oncogenic Human Papillomavirus (HPV) detection in pregnant adolescents, to clarify the prevalence and risk factors, considering the importance and lack of data on this topic in Brazil. Methods A cross-sectional study was conducted with adolescents receiving prenatal care in a tertiary hospital in São Paulo, Brazil, with routine Pap smear and oncogenic HPV detection test in the uterine cervix. The authors sought to associate the results of these tests with demographic and obstetric variables. Results A total of 303 pregnant adolescents whose mean age was 15.30 ± 1.22 years comprised the study subjects. The frequency of high-risk HPV cervical detection was 50.50%. Multivariate analysis revealed that a large number of partners in their lifetime (OR = 1.27) and having a religion (OR = 2.05) were risk factors for cervical detection of oncogenic HPV, while schooling appeared as a protective factor (OR = 0.85). There was an association between this detection and colpocytological alterations, reaching almost 30% of patients, but without association with obstetric and neonatal outcomes. Conclusion The prevalence found is one of the highest in Brazil and worldwide. A greater number of partners during their lifetime and having religion were detected as possible factors associated with cervical HPV detection. Detection of cervical HPV-DNA did not influence obstetric and neonatal outcomes. The findings of this study reinforce the need to implement educational measures capable of modifying the incidence of sexually transmitted infections in this population and capable of promoting adherence to HPV vaccination programs.