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au:Francisco, Juliana B.

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Efficiency of a digital electrofulguration system in contaminated root canals in vitro
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Silva, Cimara B. B.

; Bronzato, Juliana D.

; Herrera, Daniel R.

; Montagner, Francisco

; Nunes, Elifas L.

; Gomes, Brenda P F A

Brazilian Dental Journal

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jun 2021, Volume 32 N. 3 Pages 1 - 9

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo A descontaminação do sistema do canal radicular (CR) é essencial para o sucesso da terapia endodôntica. Neste estudo in vitro, foi avaliado o potencial de desinfecção de um dispositivo de eletrofulguração, o Endox® Endodontic System (EES), em CR infectado com Enterococcus faecalis. Sessenta e cinco pré-molares inferiores humanos foram instrumentados com o sistema MTwo®. As amostras foram distribuídas em seis grupos experimentais (n = 10), de acordo com o protocolo de irrigação: clorexidina gel a 2% (CHX); CHX + EES; Hipoclorito de sódio 5,25% (NaOCl); NaOCl + EES; solução salina (SS); e SS + EES. Cinco amostras não foram tratadas (controle). As amostras de CR foram coletadas antes (C1) e após o tratamento com EES (C2), após preparo químico-mecânico (PQM) (C3) e após o tratamento final com EES (C4). Todas as amostras foram plaqueadas para unidades formadoras de colônias (CFU / mL) em meio sólido. Os dados foram analisados pelos testes de Wilcoxon e Friedman para comparações intragrupos e pelo teste de Kruskal Wallis, seguidos pelo teste de Dunn para comparações intergrupos (α = 0,05). O tratamento com o EES não reduziu significativamente o número de CFU / mL em comparação com os níveis basais (C1 vs. C2, p> 0,05). Após PQM (C3), todos os grupos apresentaram uma quantidade significativamente reduzida de CFU / mL (p <0,05), sem diferença entre as amostras tratadas com CHX e NaOCl (p> 0,05). Por fim, o tratamento com o EES após PQM (C4) não reduziu significativamente a quantidade de CFU / mL (C3 vs. C4, p> 0,05). Concluindo, o uso do Endox® Endodontic System não resultou em redução bacteriana considerável em todos os momentos operatórios, enquanto os tratamentos com NaOCl e CHX foram igualmente eficientes para esse fim.

Abstract Decontamination of the root canal (RC) system is essential for successful endodontic therapy. In this in vitro study, it was evaluated the disinfection potential of an electrofulguration device, the Endox® Endodontic System (EES), in RC infected with Enterococcus faecalis. Sixty-five human lower premolars were instrumented with MTwo® system. The specimens were distributed into six experimental groups (n = 10), according to the irrigation protocol: 2% chlorhexidine gel (CHX); CHX + EES; 5.25% sodium hypochlorite (NaOCl); NaOCl + EES; saline solution (SS); and SS + EES. Five specimens were untreated (control). RC samples were collected before (C1) and after EES treatment (C2), after chemo-mechanical preparation (CMP) (C3), and after final EES treatment (C4). All samples were plated for colony forming units (CFU/mL) onto solid media. The data were analyzed by Wilcoxon and Friedman tests for intragroup comparisons and by Kruskal Wallis test followed by Dunn’s test for intergroup comparisons (α = 0.05). Treatment with the EES did not significantly reduce the number of CFU/mL as compared to baseline levels (C1 vs. C2, p> 0.05). After CMP (C3), all groups showed a significantly reduced amount of CFU/mL (p <0.05), with no difference between CHX- and NaOCl-treated samples (p >0.05). Lastly, treatment with the EES following CMP (C4) did not significantly reduce the amount of CFU/mL (C3 vs. C4, p> 0.05). To conclude, the use of the Endox® Endodontic System did not result in considerable bacterial reduction at all operative times, while treatment with NaOCl and CHX was equally efficient for this purpose.

https://doi.org/10.1590/0103-6440202104067 30 downloads

Presencia de aflatoxina M1 en fórmulas lácteas infantiles comercializadas en el área metropolitana a Asunción, Paraguay
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Arrúa, Andrea Alejandra

; David Arrua, Pablo

; Ulke, María Gabriela

; Quezada Viay, Martha Yolanda

; Moreno Lara, Josefina

; Moura Mendes, Juliana

; Cazal, Cinthia

; Ferreira, Francisco

; Mohan Kohli, Man

; López-Nicora, Horacio

; Fernández-Rios, Danilo

Pediatría (Asunción)

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apr 2021, Volume 48 N. 1 Pages 37 - 43

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

ABSTRACT Introduction: Aflatoxin M1 (AFM1) is a toxic metabolite derived from aflatoxin B. Its ingestion in infants has been related to growth retardation, increased susceptibility to infectious diseases, reduced immunization efficiency, and cirrhosis. In Paraguay, exclusive breastfeeding is recommended up to 6 months of age, however, different brands of infant formulas targeted at this age range are marketed. Objective: To detect and quantify the presence of AFM1 in infant formulas marketed in the Metropolitan Area. Materials and Methods: Fluid (n = 18) and powder (n = 91) formulas for infants aged 0 to 12 months were purchased from pharmacies and supermarkets in the Metropolitan Area of Asunción and were analyzed using the enzyme-linked immunoaffinity assay (ELISA). Results: 9.75% (0 to 6 months) and 2% (6 to 12 months) of the powdered milk formulas and 100% of the fluid formulas were positive for AFM1. The median content of AFM1 in powder formulas was 1820 ng/kg and 510 ng/kg in brands A and B, while in liquid formulas it was 31.8 ng/kg and 33.6 ng/kg for the two brands analyzed respectively (p = 0.0001). Conclusions: AFM1 was detected in all the liquid formulas analyzed, and in 2 and 9.7% of the powder formulas of brands A and B, respectively. The levels of AFM1 were higher in the powder formulas.

RESUMEN Introducción: La aflatoxina M1 (AFM1) es un metabolito tóxico derivado de la aflatoxina B. Su ingestión en lactantes se ha relacionado con retraso en el crecimiento, aumento de susceptibilidad a enfermedades infecciosas, reducción de la eficiencia en la inmunización y cirrosis. En Paraguay se recomienda lactancia exclusiva hasta los 6 meses, sin embargo se comercializan diferentes marcas de fórmulas infantiles dirigidas a lactantes menores de 6 meses. Objetivo: Detectar y cuantificar la presencia de AFM1 en fórmulas para lactantes comercializadas en el Área Metropolitana. Materiales y Métodos: Se adquirieron fórmulas fluidas (n=18) y en polvo (n=91) para lactantes de 0 a 12 meses de farmacias y supermercados del Área Metropolitana de Asunción y fueron analizados mediante el ensayo de inmunoafinidad ligado a enzimas (ELISA). Resultados: 9,75% (0 a 6 meses) y 2% (6 a 12 meses) de las fórmulas lácteas en polvo y 100% de las fórmulas fluidas resultaron positivas para AFM1. La mediana de contenido de AFM1 en formulas en polvo fue de 1820 ng/kg y 510 ng/kg en las marcas A y B. En las fórmulas líquidas fue de 31,8 ng/kg y 33,6 ng/kg para las dos marcas analizadas respectivamente, p=0,0001. Conclusiones: Se detectó AFM1 en todas las fórmulas líquidas analizadas, y en el 2 y 9,7% de las fórmulas en polvo de las marcas Ay B respectivamente Los niveles de AFM1 fueron mayores en las fórmulas en polvo.

https://doi.org/10.31698/ped.48012021007 226 downloads

Baryon Acoustic Oscillations from Integrated Neutral Gas Observations: an instrument to observe the 21cm hydrogen line in the redshift range 0.13 < z < 0.45 – status update
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WUENSCHE, CARLOS A.

; ABDALLA, ELCIO

; ABDALLA, FILIPE

; BAROSI, LUCIANO

; WANG, BIN

; AN, RUI

; BARRETOS, JOÃO A. M.

; BATTYE, RICHARD

; BRITO, FRANCISCO A.

; BROWNE, IAN

; CORREIA, DANIEL

; COSTA, ANDRÉ A.

; DELABROUILLE, JACQUES

; DICKINSON, CLIVE

; FENG, CHANG

; FERREIRA, ELISA G. M.

; FORNAZIER, KARIN

; DE GASPERIS, GIANCARLO

; GUTIERREZ, PRISCILA

; HARPER, STUART

; LANDIM, RICARDO G.

; LICCARDO, VINCENZO

; MA, YIN-ZHE

; MACHADO, TELMO

; MAFFEI, BRUNO

; MARINS, ALESSANDRO

; MENDES, MILENA M. M.

; MERICIA, EDUARDO

; MONSTEIN, CHRISTIAN

; MOTTA, PABLO

; NOVAES, CAMILA

; OTOBONE, CARLOS H.

; PEEL, MICHAEL

; QUEIROZ, AMILCAR R.

; RADCLIFFE, CHRISTOPHER

; REMAZEILLES, MATHIEU

; RIBEIRO, RAFAEL M. G.

; SANG, YU

; SANTOS, JULIANA F. R.

; SANTOS, LARISSA

; SANTOS, MARCELO. V.

; SHAN, CHENXI

; SILVA, GUSTAVO B.

; VIEIRA, FREDERICO

; VIEIRA, JORDANY

; VILLELA, THYRSO

; XIAO, LINFENG

; YANG, WEIQIANG

; ZHANG, JIAJUN

; ZHANG, XUE

; ZHU, ZENGHAO

Anais da Academia Brasileira de Ciências

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2021, Volume 93 elocation e20201096

Abstract: En | Text: En | PDF: En

Abstract BINGO (BAO from Integrated Neutral Gas Observations) is a unique radio telescope designed to map the intensity of neutral hydrogen distribution at cosmological distances, making the first detection of Baryon Acoustic Oscillations (BAO) in the frequency band 980 MHz - 1260 MHz, corresponding to a redshift range 0.127 < z < 0.449. BAO is one of the most powerful probes of cosmological parameters and BINGO was designed to detect the BAO signal to a level that makes it possible to put new constraints on the equation of state of dark energy. The telescope will be built in Paraíba, Brazil and consists of two \thicksim 40m mirrors, a feedhorn array of 50 horns, and no moving parts, working as a drift-scan instrument. It will cover a 15 ^{\circ} ∘ declination strip centered at \sim \delta ∼ δ =-15 ^{\circ} ∘, mapping \sim ∼ 5400 square degrees in the sky. The BINGO consortium is led by University of São Paulo with co-leadership at National Institute for Space Research and Campina Grande Federal University (Brazil). Telescope subsystems have already been fabricated and tested, and the dish and structure fabrication are expected to start in late 2020, as well as the road and terrain preparation.

https://doi.org/10.1590/0001-3765202120201096 413 downloads

ERICA: prevalences of hypertension and obesity in Brazilian adolescents
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Bloch, Katia Vergetti

; Klein, Carlos Henrique

; Szklo, Moyses

; Kuschnir, Maria Cristina C

; Abreu, Gabriela de Azevedo

; Barufaldi, Laura Augusta

; Veiga, Gloria Valeria da

; Schaan, Beatriz

; Silva, Thiago Luiz Nogueira da

; Moraes, Ana Julia Pantoja

; Oliveira, Ana Mayra Andrade de

; Tavares, Bruno Mendes

; Magliano, Erika da Silva

; Oliveira, Cecília Lacroix de

; Cunha, Cristiane de Freitas

; Giannini, Denise Tavares

; Belfort, Dilson Rodrigues

; Santos, Eduardo Lima

; Leon, Elisa Brosina de

; Oliveira, Elizabete Regina Araújo

; Fujimori, Elizabeth

; Borges, Ana Luíza

; Vasconcelos, Francisco de Assis Guedes

; Azevedo, George Dantas

; Brunken, Gisela Soares

; Guimarães, Isabel Cristina Britto

; Faria Neto, José Rocha

; Oliveira, Juliana Souza

; Carvalho, Kenia Mara B. de

; Gonçalves, Luis Gonzaga de Oliveira

; Monteiro, Maria Inês

; Santos, Marize M.

; Jardim, Paulo César B. Veiga

; Ferreira, Pedro Antônio Muniz

; Montenegro Jr., Renan Magalhães

; Gurgel, Ricardo Queiroz

; Vianna, Rodrigo Pinheiro

; Vasconcelos, Sandra Mary

; Goldberg, Tamara Beres Lederer

Revista de Saúde Pública

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2016, Volume 50 Suppl. 1 elocation 9s

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO OBJETIVO Estimar as prevalências de hipertensão arterial e obesidade e a fração atribuível populacional de hipertensão arterial devida à obesidade em adolescentes brasileiros. MÉTODOS Foram avaliados dados dos participantes do Estudo de Riscos Cardiovasculares em Adolescentes, estudo seccional l nacional de base escolar. A amostra foi dividida em 32 estratos geográficos e conglomerados de escolas e turmas, com representatividade nacional, macrorregional e de capitais. Obesidade foi classificada pelo índice de massa corporal segundo idade e sexo. Considerou-se hipertensão arterial a média da pressão arterial sistólica ou diastólica maior ou igual ao percentil 95 da curva de referência. Foram estimadas prevalências e intervalos de confiança de 95% (IC95%) de hipertensão arterial e de obesidade, nacionais e nas macrorregiões do País, por sexo e grupo etário, assim como as frações de hipertensão atribuíveis à obesidade na população. RESULTADOS Foram avaliados 73.399 estudantes, 55,4% do sexo feminino, com média de idade 14,7 anos (DP = 1,6). A prevalência de hipertensão arterial foi 9,6% (IC95% 9,0-10,3); sendo as mais baixas observadas nas regiões Norte, 8,4% (IC95% 7,7-9,2) e Nordeste, 8,4% (IC95% 7,6-9,2) e a mais alta na região Sul, 12,5% (IC95% 11,0-14,2). A prevalência de obesidade foi 8,4% (IC95% 7,9-8,9), mais baixa na região Norte e mais alta na Sul. As prevalências de hipertensão arterial e obesidade foram maiores no sexo masculino. Adolescentes com obesidade tiveram prevalência de hipertensão arterial mais elevada, 28,4% (IC95% 25,5-31,2), do que aqueles com sobrepeso, 15,4% (IC95% 13,8-17,0), ou eutróficos, 6,3% (IC95% 5,6-7,0). A fração de hipertensão arterial atribuível à obesidade foi de 17,8%. CONCLUSÕES O ERICA foi o primeiro estudo brasileiro com representatividade nacional a estimar a prevalência de hipertensão arterial aferida em adolescentes. A fração da prevalência de hipertensão arterial atribuível à obesidade mostrou que cerca de 1/5 dos hipertensos poderiam não ser hipertensos se não fossem obesos.

ABSTRACT OBJECTIVE To estimate the prevalence of arterial hypertension and obesity and the population attributable fraction of hypertension that is due to obesity in Brazilian adolescents. METHODS Data from participants in the Brazilian Study of Cardiovascular Risks in Adolescents (ERICA), which was the first national school-based, cross-section study performed in Brazil were evaluated. The sample was divided into 32 geographical strata and clusters from 32 schools and classes, with regional and national representation. Obesity was classified using the body mass index according to age and sex. Arterial hypertension was defined when the average systolic or diastolic blood pressure was greater than or equal to the 95th percentile of the reference curve. Prevalences and 95% confidence intervals (95%CI) of arterial hypertension and obesity, both on a national basis and in the macro-regions of Brazil, were estimated by sex and age group, as were the fractions of hypertension attributable to obesity in the population. RESULTS We evaluated 73,399 students, 55.4% female, with an average age of 14.7 years (SD = 1.6). The prevalence of hypertension was 9.6% (95%CI 9.0-10.3); with the lowest being in the North, 8.4% (95%CI 7.7-9.2) and Northeast regions, 8.4% (95%CI 7.6-9.2), and the highest being in the South, 12.5% (95%CI 11.0-14.2). The prevalence of obesity was 8.4% (95%CI 7.9-8.9), which was lower in the North region and higher in the South region. The prevalences of arterial hypertension and obesity were higher in males. Obese adolescents presented a higher prevalence of hypertension, 28.4% (95%CI 25.5-31.2), than overweight adolescents, 15.4% (95%CI 17.0-13.8), or eutrophic adolescents, 6.3% (95%CI 5.6-7.0). The fraction of hypertension attributable to obesity was 17.8%. CONCLUSIONS ERICA was the first nationally representative Brazilian study providing prevalence estimates of hypertension in adolescents. Regional and sex differences were observed. The study indicates that the control of obesity would lower the prevalence of hypertension among Brazilian adolescents by 1/5.

https://doi.org/10.1590/s01518-8787.2016050006685 1511 downloads

ERICA: prevalences of hypertension and obesity in Brazilian adolescents
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Bloch, Katia Vergetti

; Klein, Carlos Henrique

; Szklo, Moyses

; Kuschnir, Maria Cristina C

; Abreu, Gabriela de Azevedo

; Barufaldi, Laura Augusta

; Veiga, Gloria Valeria da

; Schaan, Beatriz

; Silva, Thiago Luiz Nogueira da

; Moraes, Ana Julia Pantoja

; Oliveira, Ana Mayra Andrade de

; Tavares, Bruno Mendes

; Magliano, Erika da Silva

; Oliveira, Cecília Lacroix de

; Cunha, Cristiane de Freitas

; Giannini, Denise Tavares

; Belfort, Dilson Rodrigues

; Santos, Eduardo Lima

; Leon, Elisa Brosina de

; Oliveira, Elizabete Regina Araújo

; Fujimori, Elizabeth

; Borges, Ana Luíza

; Vasconcelos, Francisco de Assis Guedes

; Azevedo, George Dantas

; Brunken, Gisela Soares

; Guimarães, Isabel Cristina Britto

; Faria Neto, José Rocha

; Oliveira, Juliana Souza

; Carvalho, Kenia Mara B. de

; Gonçalves, Luis Gonzaga de Oliveira

; Monteiro, Maria Inês

; Santos, Marize M.

; Jardim, Paulo César B. Veiga

; Ferreira, Pedro Antônio Muniz

; Montenegro Jr., Renan Magalhães

; Gurgel, Ricardo Queiroz

; Vianna, Rodrigo Pinheiro

; Vasconcelos, Sandra Mary

; Goldberg, Tamara Beres Lederer

Revista de Saúde Pública

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2016, Volume 50 Suppl. 1 elocation 9s

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

https://doi.org/10.1590/s01518-8787.2016050006685 18629 downloads

Motor development of children with attention deficit hyperactivity disorder
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Rosa Neto, Francisco

; Goulardins, Juliana B.

; Rigoli, Daniela

; Piek, Jan P.

; Oliveira, Jorge A. de

Brazilian Journal of Psychiatry

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sep 2015, Volume 37 N. 3 Pages 228 - 234

Abstract: En | Text: En | PDF: En

Objective: To compare both global and specific domains of motor development of children with attention deficit hyperactivity disorder (ADHD) with that of typically developing children. Methods: Two hundred children (50 children with clinical diagnoses of ADHD, according to the DSM-IV-TR and 150 typically developing controls), aged 5 to 10 years, participated in this cross-sectional study. The Motor Development Scale was used to assess fine and global motricity, balance, body schema, and spatial and temporal organization. Results: Between-group testing revealed statistically significant differences between the ADHD and control groups for all domains. The results also revealed a deficit of nearly two years in the motor development of children with ADHD compared with the normative sample. Conclusion: The current study shows that ADHD is associated with a delay in motor development when compared to typically developing children. The results also suggested difficulties in certain motor areas for those with ADHD. These results may point to plausible mechanisms underlying the relationship between ADHD and motor difficulties.

https://doi.org/10.1590/1516-4446-2014-1533 13709 downloads

Babesiosis and anaplasmosis in dairy cattle in Northeastern Brazil
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Souza, Francisco de A.L.

; Braga, Juliana F.V.

; Pires, Lidiany V.

; Carvalho, Ciro J.S. de

; Costa, Érica A.

; Ribeiro, Múcio F.B.

; Santos, Renato L.

; Silva, Silvana M.M.S.

Pesquisa Veterinária Brasileira

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sep 2013, Volume 33 N. 9 Pages 1057 - 1061

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

O objetivo deste estudo foi caracterizar a situação epidemiológica e os fatores envolvidos na prevalência da babesiose e anaplasmose em bovinos da bacia leiteira de Parnaíba, Piauí, Brasil. O estudo foi realizado em 22 propriedades, sendo coletadas amostras de sangue de 202 bovinos para estudos sorológicos, moleculares e determinação do volume globular (VG). Nas propriedades foram aplicadas inquéritos envolvendo aspectos epidemiológicos. As taxas de soroprevalência foram: 52,5% para Babesia bigemina, 68,8% B. bovis, e 89,1% para Anaplasma marginale. Das amostras analisadas, 73,3% foram reagentes para Babesia spp. e A. marginale, demostrando co-infecção. Na PCR, B. bigemina e B. bovis foram positivas em 52,0% e 33,2% respectivamente, e A. marginale em 76,2%. Destes, 51,5% amplificaram DNA de Babesia spp. e A. marginale. O manejo semi-intensivo predominou em 68,0% das propriedades estudadas. O histórico clínico de babesiose e anaplasmose foi relatado em 73% das propriedades. Não houve diferença significativa (p>0,05) entre as faixas etárias e para o VG de animais positivos comparados com os negativos. O estudo indica que nesta região há instabilidade enzoótica para babesiose e estabilidade enzoótica para anaplasmose, reforçando o fato de que, no Brasil, existem áreas de instabilidade enzoótica, mesmo em regiões tropicais do país. A técnica de PCR demonstrou ser uma ferramenta valiosa para o diagnóstico destas doenças e pode ser utilizada para caracterizar uma região geográfica.

The goal of this study was to characterize the epidemiological situation and the factors involved in the prevalence of babesiosis and anaplasmosis in cattle in the dairy basin of Parnaíba, Piauí, Brazil. The study was conducted in 22 farms, and collected blood samples from 202 cattle to study serological, molecular and determination of the packed cell volume (PCV). On the farms were applied surveys involving epidemiological aspects. Seroprevalence rates were: Babesia bigemina 52.5%, B. bovis 68.8%, and Anaplasma marginale 89.1%. Of the samples analyzed, 73.3% were reactive for Babesia spp. and A. marginale, showing co-infection. In PCR, B. bigemina and B. bovis were positive in 52.0% and 33.2% respectively, and A. marginale in 76.2%. Of these, 51.5% amplified DNA of Babesia spp. and A. marginale. The semi-intensive management predominated in 68.0% of the farms studied. The clinical history of babesiosis and anaplasmosis, was reported from 73% of the farms. There was no significant difference (p>0.05) between age groups and for the PCV of positive compared with negative animals. The study indicates that in this region is enzootic instability for babesiosis and enzootic stability for anaplasmosis, reinforcing the fact that in Brazil there are areas of enzootic instability, even in tropical regions of the country. The PCR technique was a valuable tool for the diagnosis of these diseases and may be used to characterize a geographic region.

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Implante transcateter de bioprótese valvular pulmonar: revisão sistemática da literatura
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Botrel, Tobias Engel Ayer

; Clark, Otávio Augusto C.

; Queiroga, Marcelo C.

; Rossi Filho, Raul I.

; Pilla, Carlo B.

; Arrieta, Raul S.

; Cristovão, Salvador

; Silva, Célia C.

; Esteves, Cesar A.

; Oliveira, Edmundo Clarindo

; Simões, Luiz Carlos

; Chamié, Francisco

; Neves, Juliana

; Max, Roberto

; Pedra, Carlos A. C.

Revista Brasileira de Cardiologia Invasiva

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jun 2013, Volume 21 N. 2 Pages 176 - 187

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

A correção cirúrgica de algumas cardiopatias congênitas complexas envolve a reconstrução da via de saída do ventrículo direito com a interposição de homoenxertos, biopróteses, enxertos de jugular bovina ou outros condutos valvulados entre o ventrículo direito e o tronco da artéria pulmonar. Apesar de essas cirurgias poderem ser realizadas com baixa mortalidade, a vida útil das válvulas ou dos condutos implantados é normalmente pequena (< 10 anos), seja por degeneração e/ou calcificação. Graus variáveis de estenose pulmonar na maioria das vezes associada a insuficiência pulmonar são consequências da degeneração dos condutos. Em 2000, Bonhoeffer et al. foram os primeiros a relatar o implante transcateter de bioprótese valvular pulmonar (ITVP) com um dispositivo que posteriormente foi denominado de válvula Melody® (Medtronic, Minneapolis, Estados Unidos). A técnica foi inicialmente desenvolvida para limitar a necessidade de múltiplos procedimentos cirúrgicos, substituindo, em última análise, uma nova troca cirúrgica valvular. Estudos subsequentes na Europa e Estados Unidos atestaram para a segurança e eficácia dessa técnica em um número maior de pacientes. Como a Agência Nacional de Vigilância Sanitária (Anvisa) concedeu a aprovação para o uso clínico da válvula biológica pulmonar transcateter Melody® em fevereiro de 2013, consideramos necessária e oportuna a avaliação judiciosa da utilização dessa nova tecnologia antes que ela fosse aplicada em larga escala em nosso país. O objetivo deste estudo foi realizar uma revisão sistemática da literatura sobre o ITVP em pacientes com disfunções de homoenxertos, condutos valvulados e biopróteses implantados cirurgicamente na via de saída do ventrículo direito.

Surgical repair of some complex congenital heart diseases involves reconstruction of the right ventricular outflow tract using homografts, bioprostheses, bovine jugular grafts or other valved conduits between the right ventricle and the main pulmonary artery. Although these surgical procedures may be performed with low mortality rates, the life span of these implanted valves or conduits is usually short (< 10 years) due to either degeneration and/or calcification. Variable degrees of pulmonary stenosis, often associated with pulmonary insufficiency, are consequences of conduit degeneration. In 2000, Bonhoeffer et al. were the first to report the transcatheter pulmonary valve implantation (TPVI) of a bioprosthetic pulmonary valve later named Melody® valve (Medtronic, Minneapolis, USA). The technique was initially developed to limit the need for multiple surgical procedures, and, ultimately, to work as a surrogate of a new surgical valve replacement. Subsequent clinical studies in Europe and the United States confirmed the safety and efficacy of this technique in a larger number of patients. Since the National Sanitary Surveillance Agency (Agência Nacional de Vigilância Sanitária - Anvisa) granted approval for clinical use of the Melody® transcatheter pulmonary biological valve in February 2103, we deemed that a judicious assessment of this new technology was timely and necessary before the widespread use in our country. The objective of this study was to perform a systematic literature review on the use of TPVI in patients with dysfunctional homografts, valved conduits and bioprostheses implanted surgically in the right ventricular outflow tract.

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Pleural tuberculosis: is radiological evidence of pulmonary-associated disease related to the exacerbation of the inflammatory response?
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Antonangelo, Leila

; Vargas, Francisco S.

; Puka, Juliana

; Seiscento, Márcia

; Acencio, Milena M. P.

; Teixeira, Lisete R.

; Terra, Ricardo M.

; Sales, Roberta K. B.

Clinics

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nov 2012, Volume 67 N. 11 Pages 1259 - 1263

Abstract: En | Text: En | PDF: En

OBJECTIVE: Pleural tuberculosis is the most frequently occurring form of extra pulmonary disease in adults. In up to 40% of cases, the lung parenchyma is concomitantly involved, which can have an epidemiological impact. This study aims to evaluate the pleural and systemic inflammatory response of patients with pleural or pleuropulmonary tuberculosis. METHODS: A prospective study of 39 patients with confirmed pleural tuberculosis. After thoracentesis, a high resolution chest tomography was performed to evaluate the pulmonary involvement. Of the 39 patients, 20 exhibited only pleural effusion, and high resolution chest tomography revealed active associated-pulmonary disease in 19 patients. The total protein, lactic dehydrogenase, adenosine deaminase, vascular endothelial growth factor, interleukin-8, tumor necrosis factor-α, and transforming growth factor-β1 levels were quantified in the patient serum and pleural fluid. RESULTS: All of the effusions were exudates with high levels of adenosine deaminase. The levels of vascular endothelial growth factor and transforming growth factor-β1 were increased in the blood and pleural fluid of all of the patients with pleural tuberculosis, with no differences between the two forms of tuberculosis. The tumor necrosis factor-α levels were significantly higher in the pleural fluid of the patients with the pleuropulmonary form of tuberculosis. The interleukin-8 levels were high in the pleural fluid of all of the patients, without any differences between the forms of tuberculosis. CONCLUSION: Tumor necrosis factor-α was the single cytokine that significantly increased in the pleural fluid of the patients with pulmonary involvement. However, an overlap in the results does not permit us to suggest that cytokine is a biological marker of concomitant parenchymal involvement. Although high resolution chest tomography can be useful in identifying these patients, the investigation of fast acid bacilli and cultures for M. tuberculosis in the sputum is recommended for all patients who are diagnosed with pleural tuberculosis.

https://doi.org/10.6061/clinics/2012(11)06 1757 downloads

10.

Environmental pollutants and stroke-related hospital admissions
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Nascimento, Luiz Fernando Costa

; Francisco, Juliana B.

; Patto, Marielle Beatriz R.

; Antunes, Angélica M.

Cadernos de Saúde Pública

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jul 2012, Volume 28 N. 7 Pages 1319 - 1324

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Alguns dos efeitos da poluição ambiental na saúde humana são conhecidos, destacando aqueles nos sistemas respiratório e cardiovascular. Este trabalho tem por objetivo estimar esses efeitos na gênese das internações por acidente vasculoencefálico. Foi um estudo ecológico realizado com dados de internações da cidade de São José dos Campos, São Paulo, Brasil, relativos aos diagnósticos de acidente vascular cerebral, entre 1º de janeiro de 2007 e 30 de abril de 2008. Os poluentes estudados foram material particulado, dióxido de enxofre e ozônio. Utilizando-se de modelo linear generalizado da regressão de Poisson, foi possível identificar exposição ao material particulado, no mesmo dia, como associado à internação por acidente vasculoencefálico (RR = 1,013; IC95%: 1,001-1,025). O aumento de 10µg/m3 desse poluente aumenta o risco de internação em 12% (RR = 1,137; IC95%: 1,014-1,276). Assim, foi possível identificar o material particulado, no modelo multipoluente, como associado à internação por acidente vasculoencefálico numa cidade de porte médio, como São José dos Campos.

Some effects of environmental pollution on human health are known, especially those affecting the respiratory and cardiovascular systems. The current study aimed to estimate these effects on the production of hospital admissions for stroke. This was an ecological study using hospital admissions data in São José dos Campos, São Paulo State, Brazil, with diagnosis of stroke, from January 1, 2007, to April 30, 2008. The target pollutants were particulate matter, sulfur dioxide, and ozone. Use of a Poisson linear regression model showed that same-day exposure to particulate matter was associated with hospitalization for stroke (RR = 1.013; 95%CI: 1.001-1.025). An increase of 10µg/m³ in this pollutant increased the risk of hospitalization by 12% (RR = 1.137; 95%CI: 1.014-1.276). In the multi-pollutant model, it was thus possible to identify particulate matter as associated with hospitalization for stroke in a medium-sized city like São José dos Campos.

2836 downloads

11.

Environmental pollutants and stroke-related hospital admissions
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Nascimento, Luiz Fernando Costa

; Francisco, Juliana B.

; Patto, Marielle Beatriz R.

; Antunes, Angélica M.

Cadernos de Saúde Pública

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jul 2012, Volume 28 N. 7 Pages 1319 - 1324

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

1783 downloads

12.

Biodiesel renovável derivado de microalgas: avanços e perspectivas tecnológicas
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Pereira, Claudio M. P.

; Hobuss, Cristiane B.

; Maciel, Juliana Villela

; Ferreira, Lizângela R.

; Del Pino, Francisco B.

; Mesko, Márcia F.

; Jacob-Lopes, Eduardo

; Colepicolo Neto, Pio

Química Nova

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2012, Volume 35 N. 10 Pages 2013 - 2018

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Microalgae are a promising source of raw material for biodiesel production. This review discusses the latest developments related to the application of microalgae biomass for biodiesel production. Characterization of fatty acid of microalgae and comparisons with other sources of raw materials and processes are presented. Furthermore, technological perspectives and approaches for growing microalgae in photobioreactors, microalgal oil extraction techniques, and procedures for synthesizing biodiesel are reviewed.

19703 downloads

13.

Comprehensive two-dimensional gas chromatography with time of flight mass spectrometry applied to analysis of Fischer-Tropsch synthesis products obtained with and without carbon dioxide addition to feed gas
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Silva, Raphael S. F.

; Tamanqueira, Juliana B.

; Dias, Julio César M.

; Passarelli, Fábio M.

; Bidart, Antonio Marcos F.

; Aquino Neto, Francisco R.

; Azevedo, Débora A.

Journal of the Brazilian Chemical Society

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nov 2011, Volume 22 N. 11 Pages 2121 - 2126

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

A cromatografia gasosa bidimensional abrangente acoplada à espectrometria de massas por tempo de vôo (CG×CG-EMTDV) foi aplicada para avaliar o efeito do CO2 sobre a distribuição dos n-alcanos, alcanos ramificados, alquenos e compostos oxigenados em produtos da reação de Fischer-Tropsch. Coeluições de material não resolvido observadas em CG convencional foram resolvidas por CG×CG-EMTDV.

Comprehensive two-dimensional gas chromatography coupled to time of flight mass spectrometry (GC × GC-TOFMS) was applied to evaluate the CO2 effect on distribution of n-alkanes, branched alkanes, alkenes and oxygen-containing compounds in Fischer-Tropsch products. GC × GC-TOFMS was able to resolve the unresolved compounds observed in conventional GC.

3361 downloads

14.

Linfedema primário congênito em bovinos Red Angus
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Macêdo, Juliana Targino S.A.

; Lucena, Ricardo B. de

; Tochetto, Camila

; Oliveira Filho, José Carlos

; Pierezan, Felipe

; Irigoyen, Luiz Francisco

; Barros, Claudio S.L.

Pesquisa Veterinária Brasileira

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sep 2009, Volume 29 N. 9 Pages 713 - 718

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Casos de linfedema congênito foram observados acometendo 12 terneiros cruza Red Angus na região Central do Rio Grande do Sul. Os terneiros afetados apresentavam graus variáveis de edema subcutâneo ao nascimento, envolvendo principalmente os membros pélvicos, mas também outras regiões do corpo. A injeção de solução a 5% de azul de metileno no espaço interdigital dos membros pélvicos de três terneiros afetados e um controle, indicaram uma interrupção no fluxo da linfa, sugerindo uma falha dos linfáticos periféricos distais em contactar os troncos centrais. Na necropsia de três terneiros afetados, edema subcutâneo foi observado de modo variável nos membros pélvicos, prepúcio e abdômen ventral. Não foi observado edema nas cavidades orgânicas. Em dois casos, observou-se hipoplasia dos linfonodos poplíteos associadas à dilatação dos vasos linfáticos. Testes de DNA demonstraram que todos os terneiros afetados nasceram de vacas inseminadas pelo mesmo touro, sugerindo uma base genética para a doença. Levando em consideração que uma pequena porcentagem de terneiros nasceram de vacas inseminadas pelo touro suspeito, é provável que um modo autossômico recessivo esteja envolvido na hereditariedade da doença.

Cases of congenital lymphedema were observed affecting 12 cross Red Angus calves from the central region of the state of Rio Grande do Sul, Brazil. Affected calves presented variable degrees of subcutaneous edema at birth, involving mainly the hind limbs but also other body regions. The injection of methylene blue dye in 5% solution into the interdigital space of the hind limbs of three affected calves and one normal control indicated an interruption of the lymph flow in the affected calves; this suggests a failure of the distal peripheral lymphatics to connect with the central trunks. At necropsy of three affected calves subcutaneous edema was variably observed in the hind limbs, prepuce and ventral abdomen. Edema of body cavities was not observed. In two cases there was hipoplasia of the popliteal lymph nodes associated to dilatation of lymphatic vessels. DNA tests demonstrated that all affected calves were born from cows sired by the same bull suggesting an inherited basis for the disease. Considering the small percentage of affected calves born from cows sired by the suspect bull it is probable that an autosomal recessive mode of inheritance is involved.

5101 downloads

15.

Biological control of Penicillium italicum, P. digitatum and P. expansum by the predacious yeast Saccharomycopsis schoenii on oranges
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Pimenta, Raphael S.

; Silva, Francisco L.

; Silva, Juliana F.M.

; Morais, Paula B.

; Braga, Danúbia T.

; Rosa, Carlos A.

; Corrêa Jr., Ary

Brazilian Journal of Microbiology

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mar 2008, Volume 39 N. 1 Pages 85 - 90

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Este estudo avaliou a capacidade de levedura Saccharomycopsis schoenii Nadson & Krassiln (UWO-PS 80-91) em controlar o crescimento dos fungos fitopatogênicos Penicillium expansum Link (UFMG 01-2002), P. italicum Wehmer (LCP 61.1199), e P. digitatum (Pers.: Fr.) (LCP 984263, LCP 68175 e LCP 4354). S. schoenii reduziu a severidade da doença em laranjas inoculadas com todos os fitopatógenos testados. Entre estes fitopatógenos, P. digitatum LCP4354 apresentou a maior virulência enquanto que P. digitatum LCP 68175 foi o mais suscetível à predação. A levedura foi capaz de permanecer viável, sem produzir lesões na superfície dos frutos por 21 dias. Outra característica desejável observada foi a ausência de produção de substâncias antagonistas. Sendo assim, este trabalho evidência o potencial de utilização da levedura S. schoenii em protocolos de controle biológico de doenças pós-colheita em laranjas.

In this study we evaluated the ability of Saccharomycopsis schoenii Nadson and Krassiln (UWO-PS 80-91) as biocontrol agent against plant pathogenic filamentous fungi P. expansum Link (UFMG 01-2002), P. italicum Wehmer (LCP 61.1199), and P. digitatum (Pers.: Fr.) (LCP 984263, LCP 68175 and LCP 4354). S. schoenii was able to reduce disease severity in oranges inoculated with all fungi. Among the phytopathogens, P. digitatum LCP4354 was the most virulent whereas P. digitatum LCP 68175 was the most susceptible to predation. The yeast was able to survive for 21 days on the fruit surface and did not produce lesions on oranges. Production of antagonistic substances by S. schoenii was not detected using standard techniques. Our results point to the potential use of S. schoenii to control postharvest phytopathogens in fruits.

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