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Prognostic value of soluble TNF receptors in Chagas cardiomyopathy: observational study
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Ávila, Matheus Ribeiro

; de Souza, Daniel Menezes de Oliveira, Lucas Fróis Fernandes Figueiredo, Pedro Henrique Scheidt Silva, Liliany Mara Carvalho Silva, Whesley Tanor Mediano, Mauro Felippe Felix Teixeira, Leonardo Augusto da Costa de Oliveira, Luciano Fonseca Lemos de Alcantara, Marcus Alessandro Faria, Sanny Cristina de Castro Arrieiro, Arthur Nascimento Mendonça, Vanessa Amaral Lacerda, Ana Cristina Rodrigues Costa, Henrique Silveira

Memórias do Instituto Oswaldo Cruz

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2025, Volume 120 elocation e240107

Abstract: En | Text: En | PDF: En

BACKGROUND Chronic Chagas cardiomyopathy (CCC) is the most severe clinical form of the Chagas disease. There is a strong correlation between soluble tumor necrosis factor receptors (sTNFR1 and sTNFR2) and cardiac and functional parameters in CCC, but their prognostic value remains unknown. OBJECTIVE To verify the prognostic value of sTNFR1 and sTNFR2 in CCC. METHODS A longitudinal study was conducted. Sixty-nine patients with CCC (53.70 ± 9.66 years, NYHA I-II) were submitted to blood collection and echocardiography, and followed for 43.81 ± 1.21 months. The outcome was determined by the combination of cardiac death, heart transplantation, or stroke. FINDINGS After the follow-up, 15 patients (22%) presented adverse cardiovascular events. Only left ventricular ejection fraction (LVEF) [heart rate at rest (HR): 0.935, 95% CI 0.878 to 0.994; p = 0.033] and sTNFR2 (HR: 1.002, 95% CI 1.001 to 1.003; p = 0.006) remained as independent predictors of adverse cardiovascular events. The optimal cutoff point to identify these patients was the value of 1784.00 pg/mL. There was a significant difference between the groups with lower and higher sTNFR2 levels (long-rank < 0.001). MAIN CONCLUSIONS High serum levels of sTNFR2, together with lower LVEF, are strong independent predictors of adverse cardiovascular events in CCC, making them valuable for risk stratification.

https://doi.org/10.1590/0074-02760240107

Catastrophic health expenditures incurred by families in 2003, 2009 and 2018 in the Federal District, Brazil: evolution and composition
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Santos, Pedro Henrique Alves

; Torres, Theo da Fonseca

; Russo, Letícia Xander

; Silva, Everton Nunes da

Epidemiologia e Serviços de Saúde

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2024, Volume 33 elocation e20231358

Abstract: Pt Es En | Text: Pt Es En | PDF: Pt | PDF: Es | PDF: En

RESUMO Objetivo Investigar a evolução da prevalência de gastos catastróficos no Distrito Federal em três momentos distintos (2003, 2009 e 2018), bem como identificar a composição dos gastos diretos em saúde dos recursos financeiros das famílias nos respectivos anos. Métodos Estudo de série temporal, usando dados da Pesquisa sobre Orçamento Familiar. A prevalência foi estratificada por quintis do consumo. Resultados Foram selecionados como amostra 754 domicílios em 2003, 695 em 2009 e 1.000 em 2018. Para o limiar de 10% do consumo, a prevalência dos gastos catastróficos foi de 12,3% (IC95% 9,6;14,9) em 2003, 15,3% (IC95% 12,1;18,3) em 2009 e 14,1% (IC95% 11,8;16,2) em 2018. Domicílios com menor renda apresentaram maior prevalência de gastos catastróficos. Medicamentos têm maior peso no gasto das famílias de baixa renda. Conclusão Houve aumento da prevalência de gastos catastróficos no Distrito Federal. Medicamentos foram o principal gasto das famílias mais pobres.

RESUMEN Objective Investigar la evolución de prevalencia del gasto catastrófico en Distrito Federal en tres momentos diferentes (2003, 2009 y 2018), así como identificar la composición del gasto directo en salud de los recursos de las familias en los respectivos años. Method Estudio de series temporales, utilizando datos descriptivos de Encuesta de Presupuestos Familiares. La prevalencia se estratificó por quintiles de consumo. Results Se seleccionaron como muestra 754 hogares en 2003, 695 en 2009 y 1.000 en 2018. El umbral del 10% del consumo, la prevalencia del gasto catastrófico fue 12,3% (IC95% 9,6;14,9) en 2003, del 15,3% (IC95% 12,1;18,3) en 2009 y del 14,1% (IC95% 11,8;16,2) en 2018. Hogares pobres tuvieron una mayor prevalencia de gastos catastróficos. Medicamentos tienen un mayor peso en los gastos de familias pobres. Conclusions Hubo un aumento en la prevalencia de gastos catastróficos en el Distrito Federal. Los medicamentos fueron el principal gasto en familias paupérrimas.

ABSTRACT Objective To investigate the evolution of prevalence of catastrophic health expenditure in the Brazilian Federal District at three different times (2003, 2009 and 2018), as well, to identify the composition of outof- pocket expenditure in the respective years. Method Time series study, using descriptive data from the Family Budget Survey. Prevalence was stratified by consumption quintiles. Results 754 households were selected as a sample in 2003, 695 in 2009 and 1,000 in 2018. Taking a 10% consumption threshold, prevalence of catastrophic expenditure was 12.3% (95%CI 9.6;14.9) in 2003, 15.3% (95%CI 12.1;18.3) in 2009 and 14.1% (95CI% 11.8;16.2) in 2018. Households with lower income had higher prevalence of catastrophic expenditure. Medicines have a greater burden on expenditure of low-income families. Conclusions There was an increase in prevalence of catastrophic expenditure in the Federal District. Medicines were the main expense for the poorest families.

https://doi.org/10.1590/s2237-96222024v33e20231358.en

Brazilian version of the “Primary Sjögren’s Syndrome - Quality of Life questionnaire (PSS-QoL)”: translation, cross-cultural adaptation and validation
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Miyamoto, Samira Tatiyama

; Serrano, Érica Vieira Gianórdoli, Ana Paula Espíndula Altoé, Lara Betini Noronha, Bianca Domingos Santos, Pedro Henrique Alves dos Pedrini, Ana Paula Truhlar Silva, Nicole Reis Souza da Favarato, Letícia Fonseca Alochio, Luíza Vallory Tomé, Weider Andrade Lackner, Angelika Valim, Valéria

Advances in Rheumatology

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2024, Volume 64 elocation 60

Abstract: En | Text: En | PDF: En

Abstract Background The Primary Sjögren’s Syndrome Quality of Life questionnaire (PSS-QoL) is the first specific instrument to assess health-related quality of life (HRQoL) in Sjögren’s disease (SjD). The aim is to translate and cross-culturally adapt the PSS-QoL into Brazilian Portuguese and to evaluate its psychometric properties. Methods The original English version was translated into Brazilian Portuguese by two native Brazilians who were proficient in the English language. The retranslation was conducted by two native Americans proficient in Brazilian Portuguese. A committee undertook an analysis of the translated and retranslated versions, resulting in the generation of the first Brazilian version, which was submitted to the cross-cultural adaptation phase. In this phase, 50 participants with SjD responded to the instrument in Stages I and II, resulting in the generation of the second and final Brazilian version. To assess the psychometric properties, demographic and clinical data were collected from 75 patients. The HRQoL questionnaires (final Brazilian version of the PSS-QoL, Short Form-36 Health Survey (SF-36) and EuroQoL-5 dimension (EQ-5D)) were completed. Construct validity was analyzed using the Pearson or Spearman correlation coefficient. Reliability was analyzed using Cronbach’s alpha and the intraclass correlation coefficient (ICC). Results Eight questions and one response item were revised due to an incomprehension rate of greater than 15% among the participants in the cross-cultural adaptation phase. The final Brazilian version of the PSS-QoL was validated, revealing a high correlation between the total score and functional capacity (r= −0.713, p < 0.001), and vitality (r= −0.770, p < 0. 001) and mental health (r= −0.742, p < 0.001) domains of the SF-36 and a moderate correlation with the other domains of the SF-36 and a moderate correlation with the EQ-5D-tto (r= −0.573, p < 0.001), and EQ-5D-VAS (r= −0.559, p < 0.001). The intraobserver (ICC = 0.939; Cronbach’s alpha = 0.964) and interobserver (ICC = 0.965; Cronbach’s alpha = 0.964) reliability of the total score showed very high consistency. Conclusion The Brazilian version of the PSS-QoL has been demonstrated to be a valid and reproducible instrument for the assessment of HRQoL in patients with SjD.

https://doi.org/10.1186/s42358-024-00395-7

Effect of dried distillers’ grains on nutrients digestibility and nitrogen metabolism of Nellore cattle fed non-forage diets
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Rosa e Silva, Pedro Ivo José Lopes da

; Silva, Yasmim Rodrigues Vilas Boas e

; Sousa, Daniel de Paula

; Paulino, Pedro Veiga Rodrigues

; Possamai, Adriano Jorge

; Freiria, Lucien Bissi da

; Rolim, Henrique Castrillon Leiva

; Dias Júnior, Waldir de Castro

; Fonseca, Alessandra Schaphauser Rosseto

; Costa, Ana Cláudia da

; Negrão, Fagton de Mattos

; Cabral, Luciano da Silva

Revista Brasileira de Zootecnia

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2024, Volume 53 elocation e20240045

Abstract: En | Text: En | PDF: En

ABSTRACT This study was carried out to evaluate the effects of corn dried distillers’ grains (DDG) levels in non-forage diets by in vitro, in situ (0 to 50%), and in vivo (0 to 40%) trials on kinetic parameters of gas production (GP) on rumen-degradable protein (RDP) and rumen-undegradable protein (RUP) as well as on nitrogen (N) metabolism in Nellore cattle. For in vitro and in situ studies, three rumen cannulated Nellore males with body weight of 340.48 ± 22.22 kg were used. For the in vivo study, five non-castrated male Nellore cattle with an initial body weight of 355.20 ± 35.28 kg and 24 ± 3 months old were used to evaluate the effect of increasing DDG levels in non-forage diets on N metabolism by a 5 × 5 Latin square design. Experimental diets were based on ground corn, cottonseed cake, urea, mineral supplement, and increasing levels of DDG replacing ground corn. The DDG levels caused a linear decrease in GP and in vitro dry matter digestibility. The DDG presented a lower dry matter digestibility (DMD) and RDP and higher RUP than corn grain and cottonseed cake, making DDG diets present lower DMD and RDP than control. The DDG levels linearly increased the intake of crude protein, neutral detergent fiber, and ether extract, whereas non-fiber carbohydrates intake decreased and tended to decrease the DMD and organic matter digestibility. The DDG levels caused a linear increase in N intake and in total, fecal, and urinary N excretion, which was the major N excretion route, causing a quadratic drop in retained N and caused a quadratic effect on alanine aminotransferase. In contrast, triglycerides were cubically affected, and total blood protein increased. Thus, DDG levels negatively affect in vitro and in situ digestibility, increasing N intake but increasing urinary N excretion.

https://doi.org/10.37496/rbz5320240045

Performance of hyaluronic acid filler in the anatomization of thin lips: case report
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Fernandes, Maria Luiza da Matta Felisberto

; Souza, Mônica Oliveira Mangelli de

; Carvalho, Pedro Henrique Rocha

; Thebit, Marcela Marçal

; Fonseca, Allyson Henrique de Andrade

RGO - Revista Gaúcha de Odontologia

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2024, Volume 72 elocation e20240040

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

ABSTRACT The goal of this study is to describe the effect of hyaluronic acid filler on thin lips, evaluating the distribution of the material and its relationship with tissue vascularization, as well as the effectiveness of structuring tissue shape and volume through the immediate clinical results achieved. In addition, this study observes the longevity of the results for a period of 10 months after performing this intervention on the lips. Methodology: A healthy 40-year-old Caucasian woman, complaining of thin lips and who had never undergone clinical or surgical procedures on her lips, participated in this study. An analysis of the lip vascularization and distribution of the filler material in the tissues was carried out using ultrasound images. The adequacy of volume, contour, lip hydration and patient satisfaction were also analyzed. Results: To achieve the desired lip profile, 3 ml of filler material was used throughout 4 sessions. Botulinum toxin therapy was applied to control the depressant muscle forces of the angle of the mouth, the orbicularis oris muscle, and the tip of the nose. A small amount of filler material was used at the tip of the nose to harmonize the facial profile. Conclusions: Thin lips required larger volumes of filler material, which was considered safe and effective if the vascularization is monitored to decide on the best insertion plan for the filler material. A combination with complementary therapies, such as the use of botulinum toxin, may be recommended for the effectiveness of the contour and shape of this lip pattern.

RESUMO O objetivo deste estudo é descrever o efeito de um preenchedor de ácido hialurônico em lábios finos, avaliando a distribuição do material e sua relação com a vascularização tecidual bem como a efetividade da estruturação da forma e volume tecidual através dos resultados imediatos e sua longevidade após o período de 10 meses. Participou deste estudo uma mulher caucasiana, 40 anos de idade, com queixa de lábios finos, que nunca havia feito qualquer procedimento clínico ou cirúrgico nos lábios e sem qualquer alteração sistêmica. Foi realizado análise da vascularização labial e distribuição do material preenchedor nos tecidos através de imagens de ultrassom. Também foram analisados a adequação do volume, contorno, hidratação dos lábios e satisfação da paciente. Para se atingir o perfil labial desejado utilizou-se 3 ml do material preenchedor ao longo de 4 sessões. Terapia com toxina botulínica foi associada para o controle das forças musculares depressoras do ângulo da boca, orbicular bucal e ponta do nariz. Uma pequena quantidade de material preenchedor foi usada na ponta do nariz para a harmonia do perfil facial. Lábios finos exigem maiores volumes de material preenchedor considerados seguros e efetivos desde que se monitore a vascularização para a decisão do melhor plano de inserção do material preenchedor. A conjugação com terapias complementares como uso da toxina botulínicas pode ser indicada para a efetividade do contorno e forma deste padrão labial.

https://doi.org/10.1590/1981-86372024004020240014

Post-discharge all-cause mortality in COVID-19 recovered patients hospitalized in 2020: the impact of chronic kidney disease
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Lomba, Guilherme Schittine Bezerra

; Silva, Pedro Henrique Abreu da

; Rosário, Natalia Fonseca do

; Medeiros, Thalia

; Alves, Lilian Santos

; Silva, Andrea Alice

; Almeida, Jorge Reis

; Lugon, Jocemir Ronaldo

Revista do Instituto de Medicina Tropical de São Paulo

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2024, Volume 66 elocation e1

Abstract: En | Text: En | PDF: En

ABSTRACT In Brazil, the COVID-19 burden was substantial, and risk factors associated with higher in-hospital mortality rates have been extensively studied. However, information on short-term all-cause mortality and the factors associated with death in patients who survived the hospitalization period of acute SARS-CoV-2 infection is limited. We analyzed the six-month post-hospitalization mortality rate and possible risk factors of COVID-19 patients in a single center in Brazil. This is a retrospective cohort study focused on a six-month follow-up. The exclusion criteria were death during hospitalization, transference to another hospital, and age under 18. We collected data from the charts of all hospitalized patients from March 2020 to December 2020 with a positive RT-PCR test for SARS-CoV-2, resulting in a sample size of 106 patients. The main outcome was death after hospitalization, whereas comorbidities and demographics were evaluated as risk factors. The crude post-hospitalization death rate was 16%. The first 30 days of follow-up had the highest mortality rate. In a Cox regression model for post-hospitalization mortality, previous chronic kidney disease (HR, 4.06, 95%CI 1.46 – 11.30) and longer hospital stay (HR 1.01, 95%CI 1.00 – 1.02) were the only factors statistically associated with death. In conclusion, a high six-month all-cause mortality was observed. Within the six-month follow-up, a higher risk of death was observed for patients who had prior CKD and longer hospital stay. These findings highlight the importance of more intensive medical surveillance during this period.

https://doi.org/10.1590/s1678-9946202466001

Tonometria Gastrointestinal no Perioperatório do Transplante Hepático: Uma Revisão Integrativa
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Brito, Tatiany Cíntia da Silva

; Xavier, Sabrina Priscila de Souza

; Teixeira, Breno Pereira

; Silva, Carolline Eronita da

; Falcão, Jefferson Aires

; Silva, Lívia Farias da

; Santana, Artur Guilherme Caldas de

; Batista, Pedro Henrique Mafra dos Santos Nogueira

; Silva, Hugo Rafael de Souza e

; Lima, Manuela Izidio de

; Fonseca Neto, Olival Cirilo Lucena da

Brazilian Journal of Transplantation

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2024, Volume 27 elocation e0424

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

ABSTRACT Introduction: Gastric tonometry is a useful tool for examining regional splanchnic perfusion as it provides an indirect assessment of the state of the liver graft. This is because splanchnic hypoperfusion is a critical parameter in the context of liver transplantation, being associated with the development of problems such as acute liver failure and multiple organ failure. Objective: To analyze the effects of gastrointestinal tonometry in the perioperative period of patients undergoing liver transplantation. Methodology This is an Integrative Review using the PubMed and VHL databases. The following descriptors were used: “Tonometry”, “Splanchnic circulation” and “Liver transplantation” with the Boolean operator “AND”, and articles of relevance to the topic were selected. Initially, 24 articles were selected, all published in the last 20 years, in Portuguese and/or English. After analysis, 6 articles matched the proposed objective. Results: It was observed that the difference between PraCO2 at the end of surgery and in the anepathic phase was greater in patients without liver graft dysfunction. A positive correlation was found between ΔpraCO2 and peak ALT after liver transplantation. In another study, it was found that the relationship between poor graft function was the presence of elevated liver enzymes, worsening synthetic liver function, coagulopathy and encephalopathy. It has also been shown that intramucosal gastric pH can predict early graft function. In a group with liver dysfunction, patients had an intramucosal gastric pH of less than 7.3 in the perioperative period, which remained low until the 24th hour postoperatively, while the group without dysfunction had an intramucosal gastric pH of more than 7.3, except in the anepathic phase when it was below this value. Conclusion: The usefulness of gastrointestinal tonometry to monitor splanchnic circulation and liver graft function during liver transplantation has been described and although support for this statement was found in some studies, this review had limitations due to the small number of articles available, which prevents it from covering a wide range of scientific evidence.

RESUMO Introdução: A tonometria gástrica é uma ferramenta útil para examinar a perfusão esplâncnica regional por permitir o fornecimento de uma avaliação indireta do estado do enxerto hepático. Isso ocorre devido à hipoperfusão esplâncnica ser um parâmetro crítico no contexto do transplante de fígado, estando associada ao desenvolvimento de problemas como insuficiência hepática aguda e falência de múltiplos órgãos. Objetivo: Analisar os efeitos da tonometria gastrointestinal no perioperatório dos pacientes submetidos ao transplante hepático. Metodologia: Trata-se de uma Revisão Integrativa realizada nas bases de dados PubMed e BVS. Foram utilizados os descritores: “Tonometry”, “Splanchnic circulation” e “Liver transplantation”, incluindo o operador booleano “AND”, e selecionados artigos de relevância para o tema. Foram selecionados inicialmente 24 artigos, todos publicados nos últimos 20 anos, em português e/ou inglês. Após análise, seis artigos corresponderam ao objetivo proposto. Resultado: Observou-se que a diferença entre a PraCO2 no final da cirurgia e na fase anepática foi maior em pacientes sem disfunção do enxerto hepático. Foi identificada uma correlação positiva entre ΔpraCO2 e o pico de ALT após o transplante de fígado. Em outro estudo, verificou-se que a presença de enzimas hepáticas elevadas e a piora da função hepática sintética, coagulopatia e encefalopatia estava relacionada à má função do enxerto. Também foi comprovado que o pH gástrico intramucoso pode predizer a funcionalidade precoce do enxerto. Em um grupo com disfunção hepática, os pacientes apresentaram pH gástrico intramucoso abaixo de 7,3 no período perioperatório, mantendo-se baixo até a 24ª hora pós-operatória, enquanto o grupo sem disfunção apresentou pH gástrico intramucoso acima de 7,3, exceto na fase anepática, quando ficou abaixo desse valor. Conclusão: Descreve-se a utilidade da tonometria gastrointestinal para monitorar a circulação esplâncnica e a função do enxerto hepático durante o transplante hepático. Embora alguns estudos ofereçam suporte a essa afirmação, esta revisão apresenta limitações devido à quantidade restrita de artigos disponíveis, o que a impede de abranger uma ampla gama de evidências científicas.

https://doi.org/10.53855/bjt.v27i1.538_port

Catastrophic health expenditures incurred by families in 2003, 2009 and 2018 in the Federal District, Brazil: evolution and composition
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Santos, Pedro Henrique Alves

; Torres, Theo da Fonseca

; Russo, Letícia Xander

; Silva, Everton Nunes da

Epidemiologia e Serviços de Saúde

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2024, Volume 33 elocation e20231358

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

https://doi.org/10.1590/s2237-96222024v33e20231358.en

Thinking Outside the Box: The Interventional Surgeon
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Maia, Adnaldo da Silveira

; Soares, Karlos Jennysson Sousa Alvarado, Pedro Esteban Ulloa Silva, Francisco Victor Alves da Mayer, Dayara Hoffmann Camacho, Mauro Henrique Batista Fonseca, José Honório de Almeida Palma da

Brazilian Journal of Cardiovascular Surgery

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2024, Volume 39 N. 3 elocation e20230207

Abstract: En | Text: En | PDF: En

ABSTRACT Advances in treatment of structural heart disease have been disruptive to cardiovascular surgery, and there have been discussions about how to incorporate these technologies into the surgeons’ therapeutic arsenal. Transcatheter procedures, complex redo interventions, and endovascular aortic approaches are already practiced by cardiovascular surgeons in Brazil. The expansion of these techniques, coupled with recent changes in the country’s medical residency program in cardiovascular surgery, has led to an urgent need to acquire catheter-based skills. In this article, we discuss these aspects in the light of the reality of cardiovascular surgery training in Brazil.

https://doi.org/10.21470/1678-9741-2023-0207

10.

Resgate vegetativo, estabelecimento in vitro e estaquia de Drimys brasiliensis Miers vegetativo
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Silva, Jaiton Jaime das Neves

; Navroski, Marcio Carlos

; Aquino, Marina Gabriela Cardoso de

; Denega, Lucas

; Fonseca, Pedro Henrique Tavares da

; Oliveira, Luciana Magda de

; Pereira, Mariane de Oliveira

Ciência Florestal

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2023, Volume 33 N. 1 elocation e69093

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Drimys brasiliensis Miers, conhecida popularmente por cataia, é uma espécie arbórea nativa da Mata Atlântica que apresenta importância fitoquímica, fitoterapêutica, aromática e econômica, com amplo uso na medicina popular. É considerada uma espécie de difícil multiplicação via sementes, apresentando dormência por imaturidade embrionária. Assim, objetivou-se com este estudo analisar o resgate vegetativo, estabelecimento in vitro e a propagação via estaquia de Drimys brasiliensis. Para o resgate, realizou-se a aplicação das técnicas de anelamento a 30 e 90 cm do solo, semianelamento a 30 cm do solo e galhos podados acondicionados vertical e horizontalmente, sendo avaliada a capacidade de emissão de brotações. Com as brotações obtidas pelo resgate vegetativo, foram confeccionados os explantes utilizados para o estabelecimento in vitro, avaliando diferentes tempos de imersão em hipoclorito de sódio 1,0 % (v/v) (0, 10, 15 e 20 minutos). Foram avaliadas as percentagens de contaminação total, bacteriana, fúngica e oxidação fenólica. Na estaquia foram testadas brotações oriundas do resgate vegetativo, da parte aérea de indivíduo adulto e de galhos destacados e acondicionados em mini-túnel. Avaliaram-se a porcentagem de sobrevivência das estacas, porcentagem de estacas com calos e porcentagem de enraizamento. Em relação ao resgate vegetativo, a técnica de galhos podados resultou na indução de brotações, destacando os galhos acondicionados verticalmente (100%). No estabelecimento in vitro, a imersão em hipoclorito de sódio (1%) por 20 minutos se mostrou eficiente no controle da contaminação por fungos, entretanto, não foram observadas diferenças significativas em relação ao controle de contaminação bacteriana. Na estaquia, o uso de estacas provenientes de galhos podados ou anelamento/semianelamento mostrou potencial para estas técnicas na clonagem da espécie, obtendo resultados próximos a 10% de enraizamento. No geral, a espécie apresenta potencial de propagação vegetativa, contudo, são necessários ajustes nos protocolos de estabelecimento in vitro e estaquia. Miers cataia fitoquímica fitoterapêutica econômica popular sementes embrionária Assim objetivouse objetivou vegetativo realizouse realizou 3 9 horizontalmente 10 1 0 1, v/v vv v (v/v 0, (0 2 minutos. . minutos) total bacteriana fenólica minitúnel. minitúnel mini túnel. túnel mini-túnel Avaliaramse Avaliaram enraizamento 100%. 100 100% (100%) 1% (1% fungos entretanto anelamentosemianelamento geral vegetativa contudo ( (100% (1 (100 (10

ABSTRACT Drimys brasiliensis Miers, popularly known as cataia, is a tree species native to the Atlantic Forest that has phytochemical, phytotherapeutic, aromatic and economic importance, with wide use in folk medicine. It is considered a species of difficult multiplication via seeds, presenting dormancy due to embryonic immaturity. Thus, the objective of this study was to analyze the vegetative rescue, in vitro establishment and propagation by way of cuttings of Drimys brasiliensis. For the rescue, the girdling techniques were applied at 30 and 90 cm from the ground, semi-girdling at 30 cm from the ground and pruned branches conditioned vertically and horizontally, being evaluated the shoot emission capacity. With the shoots obtained by vegetative rescue, the explants used for in vitro establishment were made, evaluating different immersion times in sodium hypochlorite 1.0 % (v/v) (0, 10, 15 and 20 minutes). The percentages of total, bacterial, fungal contamination and phenolic oxidation were evaluated. On the cuttings, shoots from vegetative rescue, from the aerial part of an adult individual and from detached branches were tested and placed in a mini-tunnel. The percentage of cuttings survival, percentage of cuttings with callus and percentage of rooting were evaluated. Regarding the vegetative rescue, the technique of pruned branches resulted in the induction of shoots, highlighting the branches conditioned vertically (100%). In the in vitro establishment, the immersion in sodium hypochlorite (1%) for 20 minutes proved to be efficient in the control of fungal contamination, however, no significant differences were observed in relation to the control of bacterial contamination. In cuttings, the use of cuttings from pruned branches or girdling/semi-girdling showed potential for these techniques in the cloning of the species, obtaining results close to 10% rooting. In general, the species has the potential for vegetative propagation, however, adjustments are necessary in the in vitro establishment and cutting protocols. Miers cataia phytochemical phytotherapeutic importance medicine seeds immaturity Thus rescue 3 9 semigirdling semi horizontally capacity made 10 1 0 1. v/v vv v (v/v 0, (0 2 minutes. . minutes) total minitunnel. minitunnel mini tunnel. tunnel mini-tunnel survival 100%. 100 100% (100%) 1% (1% however girdling/semigirdling girdlingsemigirdling girdling/semi general protocols ( (100% (1 girdlingsemi (100 (10

https://doi.org/10.5902/1980509869093

11.

First report of putative Leishmania RNA virus 2 (LRV2) in Leishmania infantum strains from canine and human visceral leishmaniasis cases in the southeast of Brazil
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Rêgo, Felipe Dutra

; da Silva, Eduardo Sérgio Lopes, Valeriana Valadares Teixeira-Neto, Rafael Gonçalves Belo, Vinícius Silva Fonseca Júnior, Antônio Augusto Pereira, Diego Andrade Pena, Heber Paulino Laurenti, Márcia Dalastra Araújo, Gabriela V da Matta, Vânia Lúcia Ribeiro Chouman, Islam Hussein Burrin, Thainá Bergantin Sandoval, Carmen M Barrouin-Melo, Stella Maria de Pinho, Flaviane Alves de Andrade, Hélida Monteiro Nunes, Ramon Vieira Gontijo, Célia Maria Ferreira Soccol, Vanete Thomaz Klocek, Donnamae Grybchuk, Danyil Macedo, Diego Henrique do Monte-Neto, Rubens Lima Yurchenko, Vyacheslav Soares, Rodrigo Pedro

Memórias do Instituto Oswaldo Cruz

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2023, Volume 118 elocation e230071

Abstract: En | Text: En | PDF: En

BACKGROUND Leishmania RNA virus 1 (LRV1) is commonly found in South American Leishmania parasites belonging to the subgenus Viannia, whereas Leishmania RNA virus 2 (LRV2) was previously thought to be restricted to the Old-World pathogens of the subgenus Leishmania. OBJECTIVES In this study, we investigated the presence of LRV2 in strains of Leishmania (L.) infantum, the causative agent of visceral leishmaniasis (VL), originating from different hosts, clinical forms, and geographical regions. METHODS A total of seventy-one isolates were screened for LRV2 using semi-nested reverse transcription-polymerase chain reaction (RT-PCR) targeting the RNA-dependent RNA polymerase (RdRp) gene. FINDINGS We detected LRV2 in two L. infantum isolates (CUR268 and HP-EMO) from canine and human cases, respectively. MAIN CONCLUSIONS To the best of our knowledge, this is the first detection of LRV2 in the New World.

https://doi.org/10.1590/0074-02760230071

12.

Brazilian Portuguese version and content validity of the Strengthening and Stretching for Rheumatoid Arthritis of the Hand (SARAH)
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Castro, Rayane Quintão

; Barros, Lívia Vilela

; Carvalho, Pedro Henrique Berbert de

; Fonseca, Diogo Simões

; Miyamoto, Samira Tatiyama

; Coelho, Cristina Martins

; Machado, Germano Luís Rocha

; Forechi, Ludimila

Advances in Rheumatology

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2023, Volume 63 elocation 2

Abstract: En | Text: En | PDF: En

Abstract Introduction The Strengthening and Stretching for Rheumatoid Arthritis of the Hand (SARAH) program is a personalized, progressive 12-week exercise program for people with hand problems due to rheumatoid arthritis (RA). Patients are provided with two guidance documents, the ‘Patient Exercise Booklet’ and the ‘Personal Exercise Guide’, to continue the exercises independently at home. Objective This study aimed to translate and culturally adapt the SARAH protocol into Brazilian Portuguese and validate its content. Methods The guidance documents ‘Patient Exercise Booklet’ and ‘Personal Exercise Guide’ of the SARAH program were translated and culturally adapted to Brazilian Portuguese. The content validity was obtained by calculating the content validity index (CVI). Results The Brazilian version of the SARAH protocol reached semantic, idiomatic, conceptual, and cultural equivalences. The CVI was greater than 0.8, corresponding to a satisfactory index. The verbal comprehension was 4.9, showing good verbal comprehension ofthe target population. Conclusion The Brazilian Portuguese version of the SARAH protocol is available to Brazilian people with compromised hands due to RA with satisfactory content validity.

https://doi.org/10.1186/s42358-022-00284-x

13.

Estratégia Fármaco-Invasiva no Infarto do Miocárdio: Análise Descritiva, Apresentação de Sintomas Isquêmicos e Preditores de Mortalidade
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Bianco, Henrique Tria

; Povoa, Rui

; Izar, Maria Cristina

; Alves, Claudia Maria Rodrigues

; Barbosa, Adriano Henrique Pereira

; Bombig, Maria Teresa Nogueira

; Gonçalves Jr, Iran

; Luna Filho, Bráulio Aguirre, Ana Caroline Moraes, Pedro Ivo de Marqui Almeida, Dirceu Moreira, Flávio Tocci Povoa, Fernando Focaccia Stefanini, Edson Caixeta, Adriano Mendes Bacchin, Amanda S. Moisés, Valdir Ambrósio Fonseca, Francisco A.H.

Arquivos Brasileiros de Cardiologia

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nov 2022, Volume 119 N. 5 Pages 691 - 702

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

Abstract Background ST-segment elevation myocardial infarction (STEMI) is defined by symptoms accompanied by typical electrocardiogram changes. However, the characterization of ischemic symptoms is unclear, especially in subgroups such as women and the elderly. Objectives To analyze the typification of ischemic symptoms, temporal metrics and observe the occurrence of in-hospital outcomes, in the analysis of predictive scores, in patients with STEMI, in a drug-invasive strategy. Methods Study involving 2,290 patients. Types of predefined clinical presentations: typical pain, atypical pain, dyspnea, syncope. We measured the time between the onset of symptoms and demand for care and the interval between arrival at the medical unit and thrombolysis. Odds-ratios (OR; CI-95%) were estimated in a regression model. ROC curves were constructed for mortality predictors. The adopted significance level (alpha) was 5%. Results Women had a high prevalence of atypical symptoms; longer time between the onset of symptoms and seeking care; delay between arrival at the emergency room and fibrinolysis. Hospital mortality was 5.6%. Risk prediction by Killip-Kimball classification: AUC: [0.77 (0.73-0.81)] in class ≥II. Subgroups studied [OR (CI-95%)]: women [2.06 (1.42-2.99); p=0.01]; chronic renal failure [3.39 (2.13-5.42); p<0.001]; elderly [2.09 (1.37-3.19) p<0.001]; diabetics [1.55 (1.04-2.29); p=0.02]; obese 1.56 [(1.01-2.40); p=0.04]: previous stroke [2.01 (1.02-3.96); p=0.04] correlated with higher mortality rates. Conclusion Despite higher mortality rates in some subgroups, significant disparity persists in women, with delays in symptom recognition and prompt thrombolysis. We highlight the applicability of the Killip-Kimball score in prediction, regardless of the clinical presentation.

Resumo Fundamento O infarto do miocárdio com elevação do segmento-ST (IAMCSST) é definido por sintomas acompanhados por alterações típicas do eletrocardiograma. Entretanto, a caracterização dos sintomas isquêmicos não é clara, principalmente em subgrupos, como mulheres e idosos. Objetivos Analisar a tipificação dos sintomas isquêmicos, métricas temporais e observar a ocorrência de desfechos intra-hospitalares, em análise dos escores preditivos, em pacientes com IAMCSST, em estratégia fármaco-invasiva. Métodos Estudo envolvendo 2.290 pacientes. Tipos de apresentações clínicas pré-definidas: dor típica, dor atípica, dispnéia, sincope. Medimos o tempo entre o início dos sintomas à demanda pelo atendimento e o intervalo entre a chegada à unidade-médica e trombólise. Odds-ratios (OR; IC-95%) foram estimadas em modelo de regressão. Curvas ROCs foram construídas para preditores de mortalidade. Nível de significância adotado (alfa) foi de 5%. Resultados Mulheres apresentaram alta prevalência de sintomas atípicos; maior tempo entre o início dos sintomas e a procura por atendimento; atraso entre a chegada ao pronto-socorro e a fibrinólise. A mortalidade hospitalar foi de 5,6%. Predição de risco pela classificação Killip-Kimball: AUC: [0,77 (0,73-0,81)] em classe ≥II. Subgrupos estudados [OR (IC-95%)]: mulheres [2,06 (1,42-2,99); p=0,01]; insuficiência renal crônica [3,39 (2,13-5,42); p<0,001]; idosos [2,09 (1,37-3,19) p<0,001]; diabéticos [1,55 (1,04-2,29); p=0,02]; obesos 1,56 [(1,01-2,40); p=0,04]; acidente vascular cerebral prévio [2,01 (1,02-3,96); p=0,04] correlacionaram-se com maiores taxas de mortalidade. Conclusão Apesar das mais altas taxas de mortalidade em alguns subgrupos, disparidade significativa persiste nas mulheres, com atrasos no reconhecimento dos sintomas e trombólise imediata. Destaca-se a aplicabilidade do escore Killip-Kimball na predição, independentemente da apresentação clínica.

https://doi.org/10.36660/abc.20211055

14.

A diversidade humana em estudos de gestão e estratégia: Um estudo bibliométrico
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Fonseca, Pedro Henrique da

; Matitz, Queila Regina de Souza

; Chaerki, Karine Francisconi

Revista Brasileira de Gestão de Negócios

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sep 2022, Volume 24 N. 3 Pages 574 - 591

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Objetivo Nosso objetivo é mostrar como a diversidade é vista e como pode ser representada como um conjunto de significados e crenças e esquemas interpretativos dentro de uma teoria do movimento social. Referencial teórico Nosso estudo está fundamentado em teorias de diversidade e de movimentos sociais. Metodologia Por meio de um estudo bibliométrico, analisamos 121 artigos publicados em 89 periódicos da área de gestão e estratégia. Os estudos foram classificados e analisados de acordo com sua distribuição em duas linhas de pesquisa. A primeira linha compreende estudos que correlacionam padrões de diferenças sociais. A segunda linha inclui estudos de diversidade desenvolvidos com base em paradigmas de pesquisa crítica sobre características relacionadas a grupos sociais específicos ou minorias. Resultados Considerando as duas linhas de pesquisa que predominam nos estudos da diversidade humana, elas apresentam focos claramente distintos em relação aos objetivos; esta pesquisa descreveu a configuração das publicações nestas linhas. Propomos quatro proposições de análise organizacional e estudos de estratégia considerando a diversidade como um movimento social. Implicações práticas e sociais da pesquisa Nosso trabalho possui uma implicação teórica, incluindo um novo conceito de organização – e nossa implicação prática é a possibilidade de um caminho inclusivo para a diversidade no contexto organizacional. Contribuições Este trabalho de pesquisa fornece insights informativos sobre o estudo dos movimentos sociais como categoria de diversidade. Também complementa a compreensão da diversidade humana como tema de interesse nos estudos organizacionais. Ele serve como informação útil para melhorar o desenvolvimento dos temas da diversidade no ambiente de trabalho.

Abstract Purpose Our aim is to demonstrate how diversity is seen and how it could be represented as a set of meanings and beliefs and interpretative schemes within a social movement theory. Theoretical framework Our study is grounded in diversity and social movement theories. Design/methodology/approach Through a bibliometric study, we analyzed 121 papers published in 89 journals in the management and strategy field. The studies were classified and analyzed according to their distribution in two lines of research. The first line comprises studies that correlate patterns in social differences. The second line includes diversity studies developed based on critical research paradigms regarding characteristics related to specific social groups or minorities. Findings Considering the two lines of research that predominate in studies of human diversity, which clearly present different focuses in relation to their objectives, this research described the configuration of publications in these lines. We offer four propositions for organizational analysis and strategy studies considering diversity as a social movement. Practical & social implications of research Our work has a theoretical implication by including a new concept of organization and our practical implication lies in the possibilities for an inclusive way to view diversity in the organizational context. Originality/value This research paper provides informative insights in studying social movements as a category of diversity. It also complements the understanding of human diversity as a topic of interest in organization studies. This serves as good information to improve the development of themes of diversity in the workplace.

https://doi.org/10.7819/rbgn.v24i3.4190

15.

Effect of the COVID-19 pandemic on patients with inherited neuromuscular disorders
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Moreno, Cristiane Araujo Martins

; Camelo, Clara Gontijo

; Sampaio, Pedro Henrique Marte de Arruda

; Fonseca, Alulin Tácio Quadros Santos Monteiro

; Estephan, Eduardo de Paula

; Silva, André Macedo Serafim

; Pirola, Renann Nunes

; Silva, Luiz Henrique Libardi

; Lima, Karlla Danielle Ferreira

; Albuquerque, Marco Antônio Veloso de

; Camelo Filho, Antonio Edvan

; Marques, Marcos Vinícius Oliveira

; Yanagiura, Mario Teruo

; Cavalcante, Wagner Cid Palmeira

; Matsui Junior, Ciro

; Isihi, Lucas Michielon de Augusto

; Mendonça, Rodrigo Holanda

; Pouza, Ana Flávia Pincerno

; Carvalho, Mary Souza de

; Reed, Umbertina Conti

; Zanoteli, Edmar

Arquivos de Neuro-Psiquiatria

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jun 2022, Volume 80 N. 6 Pages 563 - 569

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Antecedentes: A Pandemia por COVID-19 tem trazido desafios subtanciais para a prática clínica no tratamento das doenças neuromusculares hereditárias (DNMh). A infecção não tem sido a única preocupação para os pacientes. O distanciamento social tem comprometido a assistência multidisciplinar, atividade física e tem trazido problemas mentais em decorrência do próprio isolamento. Nós apresentamos aqui um seguimento de 363 pacientes com DNMh de um centro terciário Brasileiro durante o pico da Pandemia de Covid-19. Objetivos: Mostrar a frequência e gravidade da infecção por Sars-Cov-2 em pacientes com DNMh e demonstrar os efeitos da pandemia nos hábitos de vida, na progressão da doença e no cuidado multidisciplinary. Métodos Trezentos e sessenta e três pacientes (58% homens and 42% mulheres) foram acompanhados por 3 meses através de 3 teleconsultas durante o pico da Pandemia de Covid-19 no Brasil. Resultados Houve um decréscimo no número de pacientes que faziam terapia física, respiratória e fonoaudiológica. Em muitos pacientes, o apetite (33%) e hábitos do sono (25%) se alteraram. Exercícios físicos e terapias foram interrompidas pela maioria dos pacientes. Physical exercises and therapies were interrupted for most of the patients. Eles relataram piora ou aparecimento de fadiga (17%), dor (17%), retrações (14%), e escoliose (7%). Irritabilidade, mudanças no sono, peso e apetite, sendo principalmente diminuição do apetite e peso foram mais frequentemente encontrados em pacientes que apresentaram piora clinica da doença. Houve uma baixa taxa de contaminação por Covid-19 (0.8%), e todos os pacientes infectado apresentaram quadro clinico leve. Conclusão O isolamento por si só se mostrou protetor na perspectiva de infecção por Covid-19, mas pode desencadear um cenário complexo com mudanças nos hábitos de vida e curso desfavorável da doença de base.

ABSTRACT Background The COVID-19 pandemic has brought substantial challenges for current practices in treating hereditary neuromuscular disorders (hNMDs). However, this infection has not been the only concern for these patients. Social distancing has compromised multidisciplinary assistance and physical activity, and has brought about several mental health issues. We presented a follow-up on 363 patients with hNMDs at a Brazilian tertiary center during the peak of the COVID-19 pandemic. Objective We aimed to show the frequency and severity of SARS-CoV-2 infection among hNMD patients and to demonstrate the effects of the pandemic on life habits, disease progression and multidisciplinary supportive care status. Methods Three hundred and sixty-three patients (58% male and 42% female) were followed for three months through three teleconsultations during the peak of the COVID-19 pandemic in Brazil. Results There were decreases in the numbers of patients who underwent physical, respiratory and speech therapies. For several patients, their appetite (33%) and sleep habits (25%) changed. Physical exercises and therapies were interrupted for most of the patients. They reported new onset/worsening of fatigue (17%), pain (17%), contractions (14%) and scoliosis (7%). Irritability and sleep, weight and appetite changes, and especially diminished appetite and weight loss, were more frequent in the group that reported disease worsening. There was a low COVID-19 contamination rate (0.8%), and all infected patients had a mild presentation. Conclusion The isolation by itself was protective from a COVID-19 infection perspective. However, this isolation might also trigger a complex scenario with life habit changes that are associated with an unfavorable course for the NMD.

https://doi.org/10.1590/0004-282x-anp-2021-0166

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