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Abstract The iAtlantic Project has established an international collaborative strategy to improve mapping and characterization of deep and open ocean ecosystems in understudied regions of the Atlantic and evaluate their health. In December 2022, the first iAtlantic expedition in the South Atlantic set off to map and explore seafloor ecosystems in the Santos Basin slope (200-1,000 m depths) in collaboration with the Petrobras ‘Santos Basin - Regional Characterization Project.’ The 17-day ‘iAtlantic_BR10-Petrobras’ cruise was conducted on board the research vessel NPqHOc Vital de Oliveira (Brazilian Navy) and performed (a) water column structure characterization, (b) seafloor morphology mapping, (c) description of benthic habitats and communities by seafloor imagery and biological/ geological sampling, and (d) ex-situ experiments to assess the functioning of sedimentary ecosystems and their responses to climate-related environmental changes. This study describes the rationale behind the iAtlantic_BR10-Petrobras cruise science plan, reports its sampling strategy and methods, and summarizes its collected data and preliminary results.

https://doi.org/10.1590/2675-2824071.23069jaap

Synthesis of Eugenol-Fluorinated Triazole Derivatives and Evaluation of Their Fungicidal Activity
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Lima, Ângela M. A.

; Paula, Wenderson T. de

; Leite, Iris C. H. L.

; Gazolla, Poliana A. R.

; Abreu, Lucas M. de

; Fonseca, Victor R.

; Romão, Wanderson

; Lacerda Jr., Valdemar

; Queiroz, Vagner T. de

; Teixeira, Róbson R.

; Costa, Adilson V.

Journal of the Brazilian Chemical Society

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oct 2022, Volume 33 N. 10 Pages 1200 - 1210

Abstract: En | Text: En | PDF: En

Eugenol (C10H12O2, 4-allyl-2-methoxyphenol) is a phenolic natural product that has several biological activities and possibilities of applications. It is herein described the synthesis of eugenol-fluorinated triazole derivatives and evaluation of their fungicidal activity. The reaction of eugenol with epichlorohydrin resulted in the preparation of (±)-2-((4-allyl-2-methoxyphenoxy)methyl)oxirane (1) in 88% yield. The azidolysis of 1 with sodium azide gave the azido-alcohol (±)-1-(4-allyl-2-methoxyphenoxy)-3-azidopropan-2-ol (2) in 94% yield. The CuAAc reaction between compound 2 and different terminal alkynes afforded a series of eleven derivatives (3a 3k) within 48-80% yield. All the synthesized compounds were characterized by infrared (IR) and nuclear magnetic resonance (1H and 13C) spectroscopies and high-resolution mass spectrometry. The in vitro inhibitory activity of the compounds on the mycelial growth of a strain of Colletotrichum sp., that causes anthracnose disease on papaya fruits, was evaluated. The best result was observed for compound 1-(4-allyl-2-methoxyphenoxy)-3-(4-(2-fluorophenyl)-1H-1,2,3-triazol-1-yl)propan-2-ol (3d) that showed a mean growth-inhibition zone of 5.10 mm in a well-diffusion assay, and may serve as a template for additional structural modifications, aiming for more potent fungicidal activity.

https://doi.org/10.21577/0103-5053.20220040

Market value of Brazilian soccer players that played 2020 series A and B of the Brazilian championship: an analysis based on quarters of birth and playing position
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Figueiredo, Lucas Savassi

; Ribeiro, Lucas de Castro

; Castro, Henrique de Oliveira

; Costa, Gustavo De Conti Teixeira

; Gomes, Lucas Morais de Souza

; Fonseca, Fabiano de Souza

Motriz: Revista de Educação Física

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2022, Volume 28 elocation e10220002822

Abstract: En | Text: En | PDF: En

Abstract Aim: The present study aimed to investigate the prevalence of RAE in soccer players from different positions in Series A and B in 2020 Brazilian soccer, as well as the impact of RAE on the estimated market value of these players. Methods: Data from 1080 male elite soccer athletes were analyzed. Athletes were grouped according to birth quarters: Q1 (January-March), Q2 (April-June), Q3 (July-September), and Q4 (October-December) and the competitive level (Series A or B). Chi-square tests (χ2) were performed to compare the birthdates’ distribution of athletes according to a competitive level and playing positions. Kruskal-Wallis test was used to compare the market values of players born in each of the quarters of the year across competitive levels and playing positions. The significance level was set at 5%. Results: The overall analyses showed the prevalence of RAE in Series A and B, with an overrepresentation of athletes born in the first two quarters of the year. The RAE analysis based on playing positions showed different from expected distributions for forwards, midfielders, and defenders in Series A. In Series B, only midfielders showed a difference from the expected distribution. As for the market values analyses, no differences were found based on the athletes’ birth quarters, regardless of competitive level or playing position. Conclusion: Our results indicate that, although RAE is prevalent in Series A and B of elite Brazilian soccer, it does not seem to influence players’ estimated market values.

https://doi.org/10.1590/s1980-6574202200002822

Pediatric patients with COVID-19 admitted to intensive care units in Brazil: a prospective multicenter study,
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Prata-Barbosa, Arnaldo

; Lima-Setta, Fernanda

; Santos, Gustavo Rodrigues dos

; Lanziotti, Vanessa Soares

; Castro, Roberta Esteves Vieira de

; Souza, Daniela Carla de

; Raymundo, Carlos Eduardo

; Oliveira, Felipe Rezende Caino de

; Lima, Lucio Flavio Peixoto de

; Tonial, Cristian Tedesco

; Colleti Jr., José

; Bellinat, Ana Paula Novaes

; Lorenzo, Vivian Botelho

; Zeitel, Raquel de Seixas

; Pulcheri, Lucas

; Costa, Fernanda Ciuffo Monte da

; La Torre, Fabíola Peixoto Ferreira

; Figueiredo, Elaine Augusta das Neves

; Silva, Thiago Peres da

; Riveiro, Paula Marins

; Mota, Isabele Coelho Fonseca da

; Brandão, Igor Bromonschenkel

; Azevedo, Zina Maria Almeida de

; Gregory, Simone Camera

; Boedo, Fernanda Raquel Oliveira

; Carvalho, Rosana Novais de

; Castro, Natália Almeida de Arnaldo Silva Rodriguez

; Genu, Daniel Hilário Santos

; Foronda, Flavia Andrea Krepel

; Cunha, Antonio José Ledo A.

; Magalhães-Barbosa, Maria Clara de

Jornal de Pediatria

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dec 2020, Volume 96 N. 5 Pages 582 - 592

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Objetivo: Descrever as características clínicas de crianças e adolescentes internados em unidade de terapia intensiva com COVID-19 confirmada. Método: Estudo prospectivo, multicêntrico, observacional, em 19 unidades de terapia intensiva pediátrica. Foram incluídos pacientes entre um mês e 19 anos, admitidos consecutivamente (março a maio de 2020). As características demográficas, clínico-epidemiológicas, o tratamento e os resultados foram coletados. Os subgrupos foram comparados de acordo com as comorbidades, idade < 1 ano e necessidade de ventilação mecânica invasiva. Um modelo de regressão logística multivariável foi utilizado para preditores de gravidade. Resultados: Setenta e nove pacientes foram incluídos (10 com síndrome inflamatória multi-ssistêmica). Mediana de idade, quatro anos; 54% eram do sexo masculino (síndrome inflamatória multissistêmica, 80%); 41% tinham comorbidades (síndrome inflamatória multissistêmica, 20%). Febre (76%), tosse (51%) e taquipneia (50%) foram comuns nos dois grupos. Sintomas graves egastrointestinais e marcadores inflamatórios mais elevados foram mais frequentes na presença de síndrome inflamatória multissistêmica. Infiltrados intersticiais pulmonares foram comuns em ambos os grupos, mas o derrame pleural foi mais prevalente no grupo com síndrome inflamatória multissistêmica (43% vs. 14%). A ventilação mecânica invasiva foi utilizada em 18% (mediana 7,5 dias); antibióticos, oseltamivir e corticosteroides foram utilizados em 76%, 43% e 23%, respectivamente, mas não a hidroxicloroquina. A mediana do tempo de permanência na unidade de terapia intensiva pediátrica foi de 5 dias; duas mortes ocorreram (3%) no grupo não- síndrome inflamatória multissistêmica. Os pacientes com comorbidades eram mais velhos, e as comorbidades foram independentemente associadas à necessidade de ventilação mecânica invasiva(OR 5,5; IC95%, 1,43-21,12; P 0,01). Conclusões: Nas unidades de terapia intensiva pediátrica brasileiras, a COVID-19 apresentou baixa mortalidade, a idade inferior a um ano não foi associada a um pior prognóstico, os pacientes com síndrome inflamatória multissistêmica apresentaram sintomas mais graves, biomarcadores inflamatórios mais elevados e uma grande predominância no sexo masculino, mas apenas a presença de comorbidades e doenças crônicas foi um preditor independente de gravidade.

Abstract Objective: To describe the clinical characteristics of children and adolescents admitted to intensive care with confirmed COVID-19. Method: Prospective, multicenter, observational study, in 19 pediatric intensive care units. Patients aged 1 month to 19 years admitted consecutively (March-May 2020) were included. Demographic, clinical-epidemiological features, treatment, and outcomes were collected. Subgroups were compared according to comorbidities, age < 1 year, and need for invasive mechanical ventilation. A multivariable logistic regression model was used for predictors of severity. Results: Seventy-nine patients were included (ten with multisystemic inflammatory syndrome). Median age 4 years; 54% male (multisystemic inflammatory syndrome, 80%); 41% had comorbidities (multisystemic inflammatory syndrome, 20%). Fever (76%), cough (51%), and tachypnea (50%) were common in both groups. Severe symptoms, gastrointestinal symptoms, and higher inflammatory markers were more frequent in multisystemic inflammatory syndrome. Interstitial lung infiltrates were common in both groups, but pleural effusion was more prevalent in the multisystemic inflammatory syndrome group (43% vs. 14%). Invasive mechanical ventilation was used in 18% (median 7.5 days); antibiotics, oseltamivir, and corticosteroids were used in 76%, 43%, and 23%, respectively, but not hydroxychloroquine. The median pediatric intensive care unit length-of-stay was five days; there were two deaths (3%) in the non- multisystemic inflammatory syndrome group. Patients with comorbidities were older and comorbidities were independently associated with the need for invasive mechanical ventilation (OR 5.5; 95% CI, 1.43-21.12; p = 0.01). Conclusions: In Brazilian pediatric intensive care units, COVID-19 had low mortality, age less than 1 year was not associated with a worse prognosis, and patients with multisystemic inflammatory syndrome had more severe symptoms, higher inflammatory biomarkers, and a greater predominance of males, but only comorbidities and chronic diseases were independent predictors of severity.

https://doi.org/10.1016/j.jped.2020.07.002 2718 downloads

Atualização das Diretrizes Brasileiras de Valvopatias – 2020
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Tarasoutchi, Flavio

; Montera, Marcelo Westerlund

; Ramos, Auristela Isabel de Oliveira

; Sampaio, Roney Orismar

; Rosa, Vitor Emer Egypto

; Accorsi, Tarso Augusto Duenhas

; Santis, Antonio de

; Fernandes, João Ricardo Cordeiro

; Pires, Lucas José Tachotti

; Spina, Guilherme S.

; Vieira, Marcelo Luiz Campos

; Lavitola, Paulo de Lara

; Ávila, Walkiria Samuel

; Paixão, Milena Ribeiro

; Bignoto, Tiago

; Togna, Dorival Júlio Della

; Mesquita, Evandro Tinoco

; Esteves, William Antônio de Magalhães

; Atik, Fernando

; Colafranceschi, Alexandre Siciliano

; Moises, Valdir Ambrósio

; Kiyose, Alberto Takeshi

; Pomerantzeff, Pablo M. A.

; Lemos, Pedro A.

; Brito Junior, Fabio Sandoli de

; Weksler, Clara

; Brandão, Carlos Manuel de Almeida

; Poffo, Robinson

; Simões, Ricardo

; Rassi, Salvador

; Leães, Paulo Ernesto

; Mourilhe-Rocha, Ricardo

; Pena, José Luiz Barros

; Jatene, Fabio Biscegli

; Barbosa, Márcia de Melo

; Abizaid, Alexandre

; Ribeiro, Henrique Barbosa

; Bacal, Fernando

; Rochitte, Carlos Eduardo

; Fonseca, José Honório de Almeida Palma da

; Ghorayeb, Samira Kaissar Nasr

; Lopes, Marcelo Antonio Cartaxo Queiroga

; Spina, Salvador Vicente

; Pignatelli, Ricardo H.

; Saraiva, José Francisco Kerr

Arquivos Brasileiros de Cardiologia

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oct 2020, Volume 115 N. 4 Pages 720 - 775

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

https://doi.org/10.36660/abc.20201047 17824 downloads

Serum amyloid A and muscle activity biomarkers in horses submitted to equestrian show jumping
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Carvalho Filho, Wilson P.

; Fonseca, Leandro A.

; Girardi, Fabricia M.

; Bento, Lucas D.

; Souto, Pollyanna C.

; Orozco, Andres M.O.

Pesquisa Veterinária Brasileira

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aug 2019, Volume 39 N. 8 Pages 668 - 671

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO: O objetivo deste estudo foi avaliar a amilóide sérica A (SAA) e biomarcadores de atividade muscular de equinos submetidos a atividade de salto, ou hipismo clássico. Para tanto, foram avaliadas as variáveis SAA, glicose, lactato e os biomarcadores creatina quinase (CK) e aspartatoaminotransferase (AST) em 10 equinos submetidos ao exercício de saltos em torneio para iniciantes. As avaliações ocorreram antes do exercício (T0), imediatamente após (T1), 30 minutos (T2), 60 minutos (T3) e 24 horas após o término (T4). Os dados foram avaliados utilizando análise de variância para medidas repetidas. O software estatístico SAEG 9.1 foi utilizado para verificar o nível de significância entre os momentos para P<0,05. A glicose diferenciou-se entre os momentos T0 (97.7±13.3mg/dL) e T1 (79.7±14.1mg/dL). O lactado apresentou elevação comparada com o momento T1(15.3±6.1mmol/L) e os demais T0 (3.8±0.8mmol/L), T2 (6.5±3.9mmol/L), T3 (5.3±2.2mmol/L) e T4 (5.1±1.6mmol/L). A CK mostrou diferença significativa entre T0 (82.8±51.2U/L) e T1 (140.1±58.5U/L) e entre T4 (74.4±43.1U/L) com T1 (140.1±58.5U/L). A AST não apresentou diferença entre os momentos. A atividade de hipismo clássico com obstáculos de um metro não induziu alterações na proteína SAA entre os momentos.

ABSTRACT: The aim of this study was to evaluate the serum amyloid A (SAA) and biomarkers of muscle activity of horses submitted to show jumping activity. To do this, the variables SAA, glucose, lactate and the biomarkers creatine kinase (CK) and aspartate amino transferase (AST) were evaluated in 10 horses submitted to the show jumping exercise in a tournament for beginners. The evaluations occurred before exercise (T0), immediately after (T1), 30 minutes (T2), 60 minutes (T3) and 24 hours after the end (T4). Data were evaluated using analysis of variance for repeated measures. The statistical software SAEG 9.1 was used to verify the level of significance between the moments for P<0.05. Glucose presented a difference between the moments T0 (97.7±13.3mg/dL) and T1 (79.7±14.1mg/dL). Lactate presented elevation in T1 (15.3±6.1mmol/L) compared to the others T0 (3.8±0.8mmol/L), T2 (6.5±3.9mmol/L), T3 (5.3±2.2mmol/L) and T4 (5.1±1.6mmol/L). The CK showed a significant difference between T0 (82.8±51.2U/L) and T1 (140.1±58.5U/L) and between T4 (74.4±43.1U/L) with T1 (140.1±58.5U/L). The AST presented no difference between moments. The show jumping activity with one-meter obstacles did not induce changes in the SAA protein between the moments.

https://doi.org/10.1590/1678-5150-pvb-6218 901 downloads

Effects of the administration of a catalase inhibitor into the fourth cerebral ventricle on cardiovascular responses in spontaneously hypertensive rats exposed to sidestream cigarette smoke
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Valenti, Vitor E.

; Abreu, Luiz Carlos de

; Fonseca, Fernando L. A.

; Adami, Fernando

; Sato, Monica A.

; Vanderlei, Luiz Carlos M.

; Ferreira, Lucas Lima

; Rodrigues, Luciano M.

; Ferreira, Celso

Clinics

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jun 2013, Volume 68 N. 6 Pages 851 - 857

Abstract: En | Text: En | PDF: En

OBJECTIVE: Previous studies have demonstrated a relationship between brain oxidative stress and cardiovascular regulation. We evaluated the effects of central catalase inhibition on cardiovascular responses in spontaneously hypertensive rats exposed to sidestream cigarette smoke. METHODS: Male Wistar Kyoto (WKY) rats and spontaneously hypertensive rats (SH) (16 weeks old) were implanted with a stainless steel guide cannula leading into the fourth cerebral ventricle (4th V). The femoral artery and vein were cannulated for arterial pressure and heart rate measurement and drug infusion, respectively. The rats were exposed to sidestream cigarette smoke for 180 minutes/day, 5 days/week for 3 weeks (CO: 100-300 ppm). The baroreflex was tested using a pressor dose of phenylephrine (8 μg/kg, bolus) and a depressor dose of sodium nitroprusside (50 μg/kg, bolus). Cardiovascular responses were evaluated before and 5, 15, 30 and 60 minutes after injection of a catalase inhibitor (3-amino-1,2,4-triazole, 0.001 g/100 μL) into the 4th V. RESULTS: Vehicle administration into the 4th V did not affect the cardiovascular response, whereas administration of the central catalase inhibitor increased the basal HR and attenuated the bradycardic peak (p<0.05) to a greater extent in WKY rats exposed to sidestream cigarette smoke than in WKY rats exposed to fresh air. However, in spontaneously hypertensive rats, the effect of the catalase inhibitor treatment was stronger in the fresh air condition (p<0.05). CONCLUSION: Administration of a catalase inhibitor into the 4th V combined with exposure to sidestream cigarette smoke has a stronger effect in WKY rats than in SH rats.

https://doi.org/10.6061/clinics/2013(06)21 1907 downloads

Tuberculosis among HIV-1-infected subjects in a tertiary out-patient service in São Paulo city, Brazil
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Casseb, Jorge

; Fonseca, Luiz Augusto M.

; Medeiros, Lucas A.

; Gonsalez, Claudio R.

; Lagonegro, Eduardo R.

; Veiga, Ana Paula Rocha

; Silva, Daniela C. da

; Mendonça, Marcelo

; Duarte, Alberto J. S.

Revista do Instituto de Medicina Tropical de São Paulo

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oct 2012, Volume 54 N. 5 Pages 257 - 259

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Atualmente, a tuberculose (TB) é considerada a doença infecciosa mais importante entre os pacientes infectados pelo HIV-1 nos países em desenvolvimento, como o Brasil. Análise retrospectiva dos casos de tuberculose ocorridos a partir de janeiro 1995 até dezembro de 2010 foi realizada em nossa coorte de 599 pacientes HIV positivos. O desfecho primário foi a ocorrência de TB ativa, e 41 casos da doença foram diagnosticados durante este período de 16 anos. As contagens médias do nadir de células T CD4 e ao momento do diagnóstico de TB foram de 146 e 217 células/mm³, respectivamente. A carga viral média de HIV foi de 5,19 log10 cópias/mL, e 59% dos pacientes estavam em tratamento com ART. A incidência de TB foi de 1,47 casos por 100 pessoas-ano, para um tempo total de seguimento da coorte de 2775 pessoas-ano. A probabilidade de sobreviver até 10 anos após o diagnóstico foi de 75% para pacientes com TB, em oposição a 96% para pacientes com outras doenças oportunistas não-TB (p = 0,03). A tuberculose pode ser considerada problema de saúde pública entre as pessoas que vivem com HIV no Brasil, apesar da ampla utilização de anti-retrovirais para o tratamento da infecção pelo HIV / AIDS.

TB is currently considered to be the most important infectious disease among HIV-1-infected subjects in developing countries, such as Brazil. A retrospective analysis of TB cases was performed, occurring from January 1995 to December 2010 in our cohort of 599 HIV positive patients. The primary outcome was the occurrence of active TB. Forty-one TB cases were diagnosed over this period of 16 years, among 599 HIV positive patients in an open cohort setting in the city of Sao Paulo, Brazil. All-time lowest mean CD4 T cell count at the time of TB diagnosis was 146 and 186 cells/mm³, respectively. The mean HIV viral load was 5.19 log10 copies/mL, and 59% of the patients were on HAART. TB incidence was 1.47 per 100 person-years, for a total follow-up time of 2775 person-years. The probability of surviving up to 10 years after diagnosis was 75% for TB patients as opposed to 96% for patients with other, non-TB opportunistic diseases (p = 0.03). TB can be considered a public health problem among people living with HIV in Brazil despite of the widespread use of antiretrovirals for the treatment of HIV infection/AIDS.

https://doi.org/10.1590/S0036-46652012000500004 3039 downloads Cited 3 times in SciELO

Desbalanço redox: NADPH oxidase como um alvo terapêutico no manejo cardiovascular
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Rabêlo, Luiza A.

; Souza, Valéria Nunes de

; Fonseca, Lucas José Sá da

; Sampaio, Walkyria O.

Arquivos Brasileiros de Cardiologia

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may 2010, Volume 94 N. 5 Pages 684 - 693

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

Vários estudos destacam as espécies reativas de oxigênio e nitrogênio (ERONs) como importantes contribuintes na patogênese de numerosas doenças cardiovasculares, incluindo hipertensão, aterosclerose e falência cardíaca. Tais espécies são moléculas altamente bioativas e com vida curta derivadas, principalmente, da redução do oxigênio molecular. O complexo enzimático da NADPH oxidase é a maior fonte dessas espécies reativas na vasculatura. Sob condições fisiológicas, a formação e eliminação destas substâncias aparecem balanceadas na parede vascular. Durante o desbalanço redox, entretanto, há um aumento na atividade da NADPH oxidase e predomínio de agentes pró-oxidantes, superando a capacidade de defesa orgânica antioxidante. Além disso, tal hiperatividade enzimática reduz a biodisponibilidade do óxido nítrico, crucial para a vasodilatação e a manutenção da função vascular normal. Apesar de a NADPH oxidase relacionar-se diretamente à disfunção endotelial, foi primeiramente descrita por sua expressão em fagócitos, onde sua atividade determina a eficácia dos mecanismos de defesa orgânica contra patógenos. As sutis diferenças existentes entre as unidades estruturais das NADPH oxidases, a depender do tipo celular que as expressa, podem ter implicações terapêuticas, permitindo a inibição seletiva do desequilíbrio redox induzido pela NADPH oxidase, sem comprometer, entretanto, sua participação nas vias fisiológicas de sinalização celular que garantem a proteção contra microorganismos.

Several studies refer to reactive oxygen and nitrogen species (RONS) as important agents in the pathogenesis of a number of heart diseases, including high blood pressure, arteriosclerosis and heart failure. Such species are highly bioactive molecules and a short life due chiefly to reduction of molecular oxygen. The enzyme complex of NADPH oxidase is the main source of these reactive species in vascular system. Under physiological conditions, formation and elimination of these substances seem balanced in vascular wall. During redox Unbalance, nonetheless, there is increase in NADPH oxidase activity and predominance of pro-oxidizing agents, surpassing the anti-oxidant capacity of the organism self-defense. Besides this, such enzyme hyperactivity reduces the bioavailability of nitric oxide, capital for vasodilation and maintenance of normal vascular function. In spite of NADPH oxidase being directly connected to the endothelial dysfunction, it was firstly described as for its expression in phagocytes, where its activity determines efficiency of organism defense mechanisms against pathogens. Slight differences between structural units of NADPH oxidases, depending on the type of cell which expresses it, may create therapeutic implications, allowing to selectively inhibiting redox unbalance triggered by NADPH oxidase, without compromising, however, its participation in physiological cellular signaling which make sure protection against micro-organisms.

Varios estudios destacan las especies reactivas de oxígeno y nitrógeno (ERON) como importantes contribuyentes en la patogénesis de numerosas enfermedades cardiovasculares, incluyendo hipertensión, aterosclerosis y falla cardíaca. Tales especies son moléculas altamente bioactivas y con vida corta derivadas, principalmente, de la reducción del oxígeno molecular. El complejo enzimático de la NADPH oxidasa es la mayor fuente de esas especies reactivas en la vasculatura. En condiciones fisiológicas, la formación y eliminación de esas sustancias aparecen balanceadas en la pared vascular. Durante el desbalance redox, sin embargo, hay un aumento en la actividad de la NADPH oxidasa y predominio de agentes prooxidantes, superando la capacidad de defensa orgánica antioxidante. Además de ello, tal hiperactividad enzimática reduce la biodisponibilidad del óxido nítrico, crucial para la vasodilatación y el mantenimiento de la función vascular normal. A pesar de que la NADPH oxidasa se relaciona directamente con la disfunción endotelial, fue primeramente descrita por su expresión en fagocitos, en los que su actividad enzimática determina la eficacia de los mecanismos de defensa orgánica contra patógenos. Las diferencias sutiles entre las unidades estructurales de las NADPH oxidasas, dependiendo del tipo celular que las expresa, pueden tener implicaciones terapéuticas, permitiendo la inhibición selectiva del desequilibrio redox inducido por la NADPH oxidasa, sin comprometer, con todo, su participación en las vías fisiológicas de señalización celular que garantizan la protección contra microorganismos.

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10.

Ablação de taquicardia ventricular idiopática com morfologia de bloqueio de ramo esquerdo localizada no tronco da artéria pulmonar
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Leite, Luiz Roberto

; Barreto, José R.

; Melo, Roberval

; Araujo, Edmur C.

; Nogueira, Luciano

; Fonseca, Lucas A.

; D'Ávila, Edson

; Gonzáles, César

; Cruz, Fernando

; Paola, Angelo A. V. de

Arquivos Brasileiros de Cardiologia

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feb 2005, Volume 84 N. 2 Pages 185 - 187

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Paciente de 26 anos, sem cardiopatia estrutural, apresentando palpitações e pré-síncopes devido à taquicardia ventricular não sustentada, foi submetida a estudo eletrofisiológico para tentativa de ablação do foco arritmogênico, usando-se como local, os critérios de mapeamento. Sem obter êxito com o mapeamento da via de saída do ventrículo direito, posicionou-se o cateter dentro da artéria pulmonar com mapeamento de foco satisfatório, eliminando a taquicardia tão logo iniciada a radiofreqüência. Durante seguimento de 14 meses, a paciente permanece assintomática, sem arritmia ao Holter e não nessecitando de drogas antiarrítmicas.

We report the case of a 26-year-old female patient with palpitations and presyncopes due to nonsustained ventricular tachycardia, who had no structural heart disease. The patient underwent electrophysiological study in an attempt to ablate the arrhythmogenic focus, whose location was determined by using mapping criteria. Because mapping of the right ventricular outflow tract was not successful, the catheter was placed inside the pulmonary artery with satisfactory mapping of the arrhythmogenic focus, and tachycardia was eliminated as soon as radiofrequency was initiated. The patient has remained asymptomatic for 14 months, with no treatment with antiarrhythmic drugs, and no arrhythmias on serial 24-hour Holter.

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