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Abstract A new concept of multisystem disease has emerged as a long-term condition following mild-severe COVID-19 infection. The main symptoms of this affection are breathlessness, chest pain, and fatigue. We present here the clinical case of four COVID-19 patients during hospitalization and 60 days after hospital discharge. Physiological impairment of all patients was assessed by spirometry, dyspnea score, arterial blood gas, and 6-minute walk test 60 days after hospital discharge, and computed tomographic scan 90 days after discharge. All patients had fatigue, which was not related to hypoxemia or impaired spirometry values, and interstitial lung alterations, which occurred in both mechanically ventilated and non-mechanically ventilated patients. In conclusion, identifying the prevalence and patterns of permanent lung damage is paramount in preventing and treating COVID-19-induced fibrotic lung disease. Additionally, and based on our preliminary results, it will be also relevant to establish long-term outpatient programs for these individuals.

https://doi.org/10.1590/1678-9199-jvatitd-2020-0157 812 downloads

An additional brain endocast of the ictidosaur Riograndia guaibensis (Eucynodontia: Probainognathia): intraspecific variation of endocranial traits
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KERBER, LEONARDO

; FERREIRA, JOSÉ DARIVAL

; FONSECA, PEDRO HENRIQUE M.

; FRANCO, ARYMATHEIA

; MARTINELLI, AGUSTÍN G.

; SOARES, MARINA BENTO

; RIBEIRO, ANA MARIA

Anais da Academia Brasileira de Ciências

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2021, Volume 93 elocation e20200084

Abstract: En | Text: En | PDF: En

Abstract Recently, the morphology and encephalization of the brain endocast of the Triassic non-mammaliaform probainognathian cynodont Riograndia guaibensis were studied. Here, we analyzed the brain endocast of an additional specimen of this species. The new endocast shows well-defined olfactory bulbs and a median sulcus dividing the hemispheres, traits that were not clearly observed in the first studied specimen. Encephalization quotients were also calculated, revealing similar values to other non-mammaliaform cynodonts and lower than those of the first analyzed specimen. The analyzed cranium is slightly larger than the first studied one and may represent an advanced ontogenetic stage. Hence, these differences may be related to the intraspecific variation of this cynodont or alternatively, to the preservation of each specimen.

https://doi.org/10.1590/0001-3765202120200084 1084 downloads

Hereditary hemochromatosis associated with the development of liver cirrhosis
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Costa, Taylla S.

; Ferreira, Jaqueline M.

; Couto, Marina F.

; Nascimento, Regina S.

Jornal Brasileiro de Patologia e Medicina Laboratorial

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2021, Volume 57 elocation e2842021

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

RESUMO A hemocromatose hereditária (HH) é uma doença autossômica recessiva, associada, na maioria das vezes, a mutações do gene HFE, que resultam em absorção contínua de ferro, ocasionando a sobrecarga dessa substância. O tecido hepático é o principal sítio de depósito do ferro; dessa forma, níveis elevados de ferro, ao interagir com o oxigênio, induzem a formação de radicais livres que irão agir sobre proteínas, lipídios e ácido desoxirribonucleico (DNA), podendo desencadear efeitos deletérios a níveis celulares e teciduais. Visando elucidar o mecanismo de desenvolvimento da cirrose hepática decorrente da sobrecarga de ferro, o objetivo deste estudo é descrever a fisiopatologia do sistema hepático em pacientes diagnosticados com HH. Para isso, foram realizadas buscas por artigos científicos nos principais bancos de dados acadêmicos. Verificamos que pacientes diagnosticados com HH apresentam maior predisposição de desenvolver cirrose hepática, pois o depósito crônico de ferro no tecido hepático provoca lesão e consequente regeneração tecidual, progredindo para formação de fibras de colágeno que circundam os hepatócitos, levando à perda da função hepática e ao desenvolvimento da cirrose. Diante disso, faz-se necessária a realização de exames como dosagem de ferro, ferritina e transferrina para avaliação dos estoques de ferro do organismo, objetivando um diagnóstico precoce da sobrecarga de ferro, a fim de evitar danos deletérios a níveis celulares e teciduais.

ABSTRACT Hereditary hemochromatosis (HH) is an autosomal recessive disease, most often associated with mutations in the HFE gene, which result in continuous absorption of iron, causing its overload. Liver tissue is the main site of iron deposition; thus, high levels of iron, when interacting with oxygen, induce the formation of free radicals that will act on proteins, lipids, and deoxyribonucleic acid (DNA), which may trigger deleterious effects at cellular and tissue levels. In order to elucidate the development and progression of liver cirrhosis due to iron overload, the purpose of this study is to describe the pathophysiology of the hepatic system in patients diagnosed with HH. For this purpose, searches for scientific articles were carried out in the main academic databases. We found that patients diagnosed with HH are more likely to develop liver cirrhosis, since chronic iron deposition in liver tissue induces injury and consequent tissue regeneration, progressing to collagen fibers synthesis surrounding the hepatocytes, leading to loss of liver function and development of cirrhosis. Therefore, it is necessary to carry out tests such as iron, ferritin and transferrin measurements, to evaluate body’s iron stores, aiming at an early diagnosis of iron overload, thus avoiding deleterious damage at cellular and tissue levels.

RESUMEN La hemocromatosis hereditária (HH) es uma enfermedad autosómica recesiva, asociada, la mayoría de las veces, a mutaciones del gen HFE, que producen absorción continua de hierro, con sobrecarga de esa sustancia. El tejido hepático es el principal sitio de almacenamiento de hierro; así, niveles elevados de hierro, al interactuar con oxígeno, inducen la formación de radicales libres que actuarán sobre proteínas, lípidos y ácido desoxirribonucléico (ADN), pudiendo acarrear efectos dañosos a nível celular y tisular. Para aclarar el mecanismo de desarrollo de la cirrosis hepática debido a sobrecarga de hierro, el objetivo de este estudio es describir la fisiopatologia del sistema hepático en pacientes diagnosticados con HH. Para eso, se efectuaron búsquedas por artículos científicos en los principales bancos de datos acadêmicos. Verificamos que pacientes diagnosticados con HH presentan mayor predisposición a desarrollar cirrosis hepática, porque el depósito crônico de hierro en el tejido hepático causa lesión y consecuente regeneración de tejido, progresando a la formación de fibras de colágeno que rodean los hepatocitos, llevando la pérdida de la función hepática y al desarrollo de la cirrosis. Ante esto, es necesario medir hierro, ferritina y transferrina para evaluación de las provisiones de hierro del cuerpo, buscando un diagnóstico temprano de la sobrecarga de hierro, para evitar efectos deletereos a nível celular y tisular.

https://doi.org/10.5935/1676-2444.20210017 438 downloads

COMVC-19: A Program to protect healthcare workers’ mental health during the COVID-19 Pandemic. What we have learned
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Fukuti, Pedro

; Uchôa, Caroline Louise Mesquita

; Mazzoco, Marina Flaborea

; Cruz, Isabella D'Andrea Garcia da

; Echegaray, Mariana V.F.

; Humes, Eduardo de Castro

; Silveira, Júlia Belizário

; Santi, Talita Di

; Miguel, Euripedes Constantino

; Corchs, Felipe

; Fatori, Daniel

; Campello, Guilherme

; Oliveira, Gabriel M. de

; Argolo, Felipe C.

; Ferreira, Felipe de M.

; Machado, Gustavo

; Argeu, Adriana

; Oliveira, Graça Maria Ramos de

; Serafim, Antônio de Pádua

; Siqueira, Luciana de Lima

; Rossi, Luciane de

; Rios, Izabel Cristina

; Oliveira, Talita Rodrigues de

; Antoniazzi, Leilane C. K.

; Gagliotti, Daniel Augusto Mori

; Abelama Neto, Emílio

; Oliveira Junior, Paulo Novais de

; Correia, Aline Villalobo

; Gonçalves, Luca Schilling

; Tortato, Liana Silva

; Busato, Wagner Machado Moraes

; Guimarães-Fernandes, Flávio

; Alves, Marcos

; Leite Netto, Oswaldo Ferreira

; Schoueri, Patrícia de Campos Lindenberg

; Roque, Márcio de Assis

; Merlin, Silvia Stahl

; Boer, Giovana Cardoso Machado

; Sallet, Paulo Clemente

; Malbergier, André

; Spedo, Mariana Abrahão

; Kamitsuji, Carla Satie

; Faria, Elizabeth de

; Moreira, Moacyr Vergara de Godoy

; Kaufman, Arthur

; Abdo, Carmita

; Scanavino, Marco de Tubino

; Lancman, Selma

; Tavares, Hermano

; Polanczyk, Guilherme

; Brunoni, André R.

; Forlenza, Orestes V.

; Barros-Filho, Tarcísio Eloy Pessoa de

Clinics

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2021, Volume 76 elocation e2631

Abstract: En | Text: En | PDF: En

OBJECTIVE: In 2020, the COVID-19 pandemic brought a work and stress overload to healthcare workers, increasing their vulnerability to mental health impairments. In response, the authors created the COMVC-19 program. The program offered preventive actions and mental health treatment for the 22,000 workers of The Hospital das Clinicas da Faculdade de Medicina da Universidade de São Paulo (HCFMUSP). This paper aims to describe its implementation and share what we have learned from this experience. METHODS: Workers were able to easily access the program through a 24/7 hotline. Additionally, a mobile phone app that screened for signs and symptoms of emotional distress and offered psychoeducation and/or referral to treatment was made available. Data from both these sources as well as any subsequent psychiatric evaluations were collected. RESULTS: The first 20 weeks of our project revealed that most participants were female, and part of the nursing staff working directly with COVID-19 patients. The most frequently reported symptoms were: anxiety, depression and sleep disturbances. The most common diagnoses were Adjustment, Anxiety, and Mood disorders. CONCLUSIONS: Implementing a mental health program in a multimodal intervention was feasible in a major quaternary public hospital. Our data also suggests that preventive actions should primarily be aimed at anxiety and depression symptoms, with a particular focus on the nursing staff.

https://doi.org/10.6061/clinics/2021/e2631

Rapid assessment of the ichthyofauna of the southern Guiana Shield tributaries of the Amazonas River in Pará, Brazil
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DUTRA, Guilherme M.

; FREITAS, Tiago M. S.

; PRUDENTE, Bruno S.

; SALVADOR, Gilberto N.

; LEÃO, Manuela D. V.

; PEIXOTO, Luiz A. W.

; MENDONÇA, Marina B.

; NETTO-FERREIRA, André L.

; SILVA, Fabio R.

; MONTAG, Luciano F. A.

; WOSIACKI, Wolmar B.

Acta Amazonica

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mar 2020, Volume 50 N. 1 Pages 24 - 36

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO O Sistema de Drenagens do Norte do Pará abrange os afluentes da margem esquerda do Rio Amazonas, na região sul do Escudo das Guianas no estado do Pará, Brasil. Cinco das áreas estaduais protegidas da região são consideradas estratégicas para a conservação da biodiversidade. No presente estudo, nós acessamos a ictiofauna das cinco áreas de proteção estadual do Sistema de Drenagens do Norte do Pará. Sete expedições foram realizadas entre os meses de janeiro de 2008 e janeiro de 2009, amostrando trechos das bacias dos rios Cuminá, Cuminapanema, Curuá, Jari, Mapuera, Nhamundá e Paru. As expedições resultaram em 286 espécies pertencentes a 38 famílias e oito ordens, incluindo sete novos registros de peixes para o Brasil, seis deles também representando novos registros para a bacia Amazônica. Nossos resultados fornecem uma base sólida para futuros programas de pesquisa e conservação nas áreas de proteção da região.

ABSTRACT The Northern Pará Drainage System encompasses the left-bank tributaries of the Amazonas River in the southern Guiana Shield region of Pará state, Brazil. Five of the region’s state protected areas are considered strategic for the conservation of its biodiversity. In the present study, we assessed the ichthyofauna of the five state protected areas of the Northern Pará Drainage System. Seven expeditions were conducted between January 2008 and January 2009, which surveyed stretches of the Cuminá, Cuminapanema, Curuá, Jari, Mapuera, Nhamundá, and Paru rivers. These surveys yielded 286 species belonging to 38 families and eight orders, including seven new records of fish species for Brazil, six of which are also new records for the Amazon basin. Our results provide a valuable database for future research and conservation programs in the protected areas of the region.

https://doi.org/10.1590/1809-4392201901402 1698 downloads

Coconstrução do apego no primeiro semestre de vida: o papel do outro nessa constituição
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Neder, Kaira

; Ferreira, Ludmilla D. M. P.

; Amorim, Katia de Souza

Psicologia USP

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2020, Volume 31 elocation e190143

Resumo A sobrevida do bebê humano é possibilitada pelo sistema de apego, na medida em que ele busca proximidade, emitindo comportamentos mediadores em direção a uma figura que lhe proporciona segurança. Reflexões provindas da existência de uma intersubjetividade inata e evidências de habilidades mais refinadas do que se conhecia à época da formulação da teoria de Bowlby levaram à hipótese de que o comportamento de apego pode ser observado antes do proposto por esse autor. Empreendeu-se um estudo de caso, em que se analisaram videogravações do primeiro semestre de vida de Marina. Selecionaram-se e analisaram-se microgeneticamente episódios de comportamento diferencial do bebê com seus cuidadores antes dos seis meses de idade; e mapearam-se os comportamentos mediadores com cada cuidador. O comportamento diferencial com uma figura discriminada foi visualizado já aos três meses de vida. Discutiram-se os processos dialógicos e culturais que repercutiram na seleção da mãe como figura de apego.

Abstract The survival of a human baby is enabled by the attachment behavioral system, as babies seek proximity, directing attachment mediator behaviors toward a figure who provides security. Reflections from the existence of a primary intersubjectivity and evidence of more refined abilities than what was known at the time in which Bowlby formulated this theory conducted us to the hypothesis that attachment is perceived before the period he proposed. We performed a case study in which we analyzed video-recordings from Marina’s six months of life. Episodes of differential behavior towards a figure were selected and micro-genetically transcribed. Moreover, mediator behaviors with each of the baby’s caregivers were mapped. Results suggested differential behavior towards a discriminated figure since her third month. The dialogical and cultural processes that reverberated in selecting the mother as the attachment figure were discussed.

Resumen La garantía de supervivencia del bebé humano es posibilitada por el sistema de apego, en la medida en que el bebé busca acercamiento, mediante comportamientos mediadores emitidos en dirección de una figura que le proporcione seguridad. Las reflexiones derivadas de la intersubjetividad innata y evidentes habilidades mucho más refinadas de lo que eran conocidas en la época de la formulación de la teoría de Bowlby llevaron a la hipótesis de que el comportamiento de apego puede observarse antes de lo propuesto por él. Se realizó un estudio de caso a partir del análisis de grabaciones en video del primer semestre de vida de Mariana. Para ello, se seleccionaron y se analizaron microgenéticamente episodios de comportamiento diferencial del bebé con cuidadores antes de los seis meses; y se enumeraron los comportamientos mediadores con cada cuidador. Los resultados sugieren que el comportamiento diferencial con una figura discriminada se observó ya a los tres meses de vida. Se discutieron los procesos dialógicos y culturales que repercutirán en la selección de la madre como la figura de apego.

Résumé La survie du jeune enfant est rendue possible par la relation d’attachement, quand il cherche de la proximité, en émettant des comportements médiateurs vers une figure qui lui fournit sécurité. Réflexions de l’existence d’une intersubjectivité innée et évidences d’habiletés raffinées qu’on connaissait à l’époque de la formulation de la théorie on conduit à l’hypothèse que le comportement d’attachement peut être observé avant la période proposé par Bowlby. On a réalisé une étude de cas où des enregistrements vidéo du premier semestre de Marina ont été analysés. Episodes de comportement différentiel du jeune enfant avec une figure discriminée avant six mois ont été sélectionnés et analysés micro génétiquement; les comportements médiateurs avec chaque soignant ont été enregistrés à intervalles. Le comportement différentiel avec une figure discriminée a été observé déjà à trois mois de vie. L’influence des processus dialogiques et culturels sur le choix de la mère comme figure d’attachement sont discutés.

https://doi.org/10.1590/0103-6564e190143 1597 downloads

Clinical biochemistry profile of American Quarter Horse broodmares fed Tifton-85 (Cynodon spp.) hay and haylage
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Guimarães, Taciano C.

; Rezende, Adalgiza S.C.

; Costa, Maria L.L.

; Ferreira, Marina G.

; Miranda, Ana. L.S.

; Botelho, Ana F.M.

; Soto-Blanco, Benito

; Melo, Marília M.

Pesquisa Veterinária Brasileira

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may 2019, Volume 39 N. 5 Pages 317 - 323

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO: A conservação do haylage (alimento pré-seco) pode ser desafiadora, considerando o aumento do risco de crescimento de fungos, com consequente produção de micotoxinas. Entretanto, quando a qualidade da higiene e armazenamento é assegurada, o haylage aumenta a palatabilidade da forragem e fornece suplemento de matéria seca suficiente ao longo do ano. Devido à falta de informação relativa aos efeitos dessa alimentação nos parâmetros sanguíneos de equinos alimentados exclusivamente com essa dieta, o objetivo do presente estudo é avaliar o perfil bioquímico sanguíneo dos equinos após administração da haylage em comparação com feno. Doze matrizes Quarto de Milha foram distribuídas em dois grupos, cada um recebendo feno ou haylage de Tifton 85 (Cynodon spp.) por um período de 28 dias. O perfil bioquímico foi realizado em cinco tempos (T) diferentes (T0, antes do início do experimento e cronologicamente, a cada sete dias após o fornecimento das dietas - T1, T2, T3 e T4) para análise de proteína total (PT) e seu perfil fracionado, das enzimas alanina aminotransferase, aspartato aminotransferase, γ-glutamil-transferase, dos produtos de catabolismo creatinina e ureia e, dos íons cálcio e fósforo. Micotoxinas no haylage foram investigadas e mantiveram-se abaixo dos limites determinados pela legislação brasileira. O perfil bioquímico revelou, somente, elevação da PT em T4 no grupo que recebeu haylage, o que pode estar relacionado à sua maior digestibilidade proteica. Nenhuma diferença foi observada nos outros parâmetros estudados em ambos os grupos experimentais. Conclui-se que Haylage é comprovadamente seguro, quando bem preparado para equinos, sem causar efeitos na saúde geral, conforme demonstrado pelos exames bioquímicos no presente estudo.

ABSTRACT: The conservation of haylage (a pre-dried feed) can be challenging, since there is an increased risk of mould growth, which can contaminate this foodstuff with mycotoxins. However, when the hygienic quality is secured, haylage enhances grass palatability and provide enough supply of dry matter throughout the year. Due to the lack of information regarding its effect on blood parameters in horses fed exclusively with this foodstuff, the aim of this study is to provide information regarding its use in comparison to hay and ensure that it does not affect horses’ biochemical profile. Twelve Quarter Horse broodmares were distributed into two groups, each fed with Tifton-85 (Cynodon spp.) hay or haylage for a period of 28 days, and the biochemical profile was done in five different times (T0 before the experiment started and, chronologically, seven days apart - T1, T2, T3 and T4), It was analyzed total protein (TP) and its fractioning; enzymes alanine aminotransferase, aspartate aminotransferase and γ-glutamyl-transferase; endogenous catabolism products urea and creatinine; and ions calcium and phosphorus. Mycotoxins in haylage were also investigated and remained below the legislation thresholds. Only TP was higher in the last sampling (T4) of the haylage group, which may be related to the foodstuff’s higher protein digestibility. No differences were observed between serum enzymes, urea, creatinine and Ca/P from both experimental groups. Haylage has proven to be safe, when well prepared for horses, without causing impairing side effects, as shown by the normal serum biochemistry parameters presented in this study.

https://doi.org/10.1590/1678-5150-pvb-5813 1020 downloads

Antiretroviral therapy-induced paradoxical worsening of previously healed Mycobacterium haemophilum cutaneous lesions in advanced HIV infection
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Eyer-Silva, Walter de Araujo

; Almeida, Marina Rodrigues de

; Martins, Carlos José

; Basílio-de-Oliveira, Rodrigo Panno

; Araujo, Luciana Ferreira de

; Basílio-de-Oliveira, Carlos Alberto

; Azevedo, Marcelo Costa Velho Mendes de

; Pinto, Jorge Francisco da Cunha

; Vasconcellos, Sidra Ezidio Gonçalves

; Rodrigues-dos-Santos, Ícaro

; MagdinierGomes, Harrison

; Suffys, Philip Noel

Revista do Instituto de Medicina Tropical de São Paulo

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2019, Volume 61 elocation e71

Abstract: En | Text: En | PDF: En

ABSTRACT Mycobacterium haemophilum is a nontuberculous mycobacterium that causes localized or disseminated disease, mainly in immunocompromised hosts. We report the case of a 35-year-old HIV-infected woman who presented with several enlarging cutaneous lesions over the arms and legs. Histopathological examination revealed the diagnosis of a cutaneous mycobacterial disease. Mycobacterial analyses unveiled M. haemophilum infection. Six months after completion of a successful antimycobacterial treatment, she developed an immune reconstitution inflammatory syndrome (IRIS). This paradoxical relapse presented as tenderness, redness and swelling at the precise sites of the healed lesions and took place in the setting of significant recovery of the CD4 cell count (from 05 to 318 cells/mm 3 ). Microbiological analyses of these worsening lesions were negative, and they spontaneously remitted without the initiation of a novel antimycobacterial treatment cycle. M. haemophilum infection should always be considered as a cause of skin lesions in immunocompromised subjects. Physicians should be aware of the possibility of IRIS as a complication of successful antiretroviral therapy in HIV-infected patients with M. haemophilum infection.

https://doi.org/10.1590/s1678-9946201961071 412 downloads

Comparative cytogenetics in three Melipona species (Hymenoptera: Apidae) with two divergent heterochromatic patterns
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Cunha, Marina Souza da

; Travenzoli, Natália Martins

; Ferreira, Riudo de Paiva

; Cassinela, Edson Kuatelela

; Silva, Henrique Barbosa da

; Oliveira, Francisco Plácido Magalhães

; Salomão, Tânia Maria Fernandes

; Lopes, Denilce Meneses

Genetics and Molecular Biology

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dec 2018, Volume 41 N. 4 Pages 806 - 813

Abstract: En | Text: En | PDF: En

Abstract The genus Melipona is subdivided into four subgenera based on morphological characteristics, and two groups based on cytogenetic patterns. The cytogenetic information on this genus is still scarce, therefore, the goal of this study was to characterize Melipona paraensis, Melipona puncticollis, and Melipona seminigra pernigra using the following techniques: C-banding, DAPI/CMA3 fluorochromes, and FISH with an 18S rDNA probe. Melipona paraensis (2n=18) and M. seminigra pernigra (2n=22) were classified as high heterochromatin content species (Group II). Their euchromatin is restricted to the ends of the chromosomes and is CMA3+; the 18S rDNA probe marked chromosome pair number 4. Melipona puncticollis (2n=18) is a low heterochromatin content species (Group I) with chromosome pair number 1 marked with CMA3 and 18S rDNA. Low heterochromatin content is a putative ancestral karyotype in this genus and high content is not a monophyletic trait (Melikerria presents species with both patterns). Differences concerning the karyotypic characteristics can be observed among Melipona species, revealing cytogenetic rearrangements that occurred during the evolution of this genus. Studies in other species will allow us to better understand the processes that shaped the chromatin evolution in Melipona.

https://doi.org/10.1590/1678-4685-gmb-2017-0330 967 downloads

10.

Preparation, Characterization and Catalytic Activity of Palladium Catalyst Supported on MgCO3 for Dynamic Kinetic Resolution of Amines
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Ferreira, Marina M. M.

; Cabreira, Camila R.

; Chaves, Pedro H. K.

; Labussiére, Gabriela M.

; Zimpeck, Renata C.

; Lima, Sania M. de

; Siqueira, Fernanda A. de

Journal of the Brazilian Chemical Society

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oct 2018, Volume 29 N. 10 Pages 2144 - 2149

Abstract: En | Text: En | PDF: En

Pd nanoparticle catalyst loading 4.7 wt.% was prepared by the deposition-precipitation method and characterized by X-ray diffraction and transmission electron microscopy (TEM). The crystallite size estimated from the integral width of the highest intensity line using the Scherrer equation was 2.3 nm. Images obtained from TEM showed an equal distribution of the particles size between 0-2 and 2-4 nm, and also a good dispersion of the nanoparticles on the catalyst support. The catalytic activity of this nanocatalyst was studied for racemization reactions of (S)-(-)-1-phenylethylamine. After that, the catalyst was used in the chemoenzymatic dynamic kinetic resolution (DKR) of some primary amines. Expressive yields and optical purities were obtained.

https://doi.org/10.21577/0103-5053.20180089 531 downloads

11.

Efecto de los antimaláricos sobre los diferentes dominios del índice de daño SLICC en pacientes de la cohorte GLADEL
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Pons-Estel, Guillermo J.

; Quintana, Rosana

; Wojdyla, Daniel

; Alarcón, Graciela S.

; Serrano, Rosa María

; Ugarte-Gil, Manuel

; Pimentel-Quiroz, Víctor

; Soriano, Enrique R.

; Catoggio, Luis J.

; Scolnik, Marina

; Sacnun, Mónica

; Saurit, Verónica

; Caeiro, Francisco

; Alvarellos, Alejandro

; Sarano, Judith

; García, Mercedes

; Onetti, Laura

; Drenkard, Cristina

; Berbotto, Guillermo

; Scherbarth, Hugo R.

; Sato, Emilia

; Bonfa, Eloisa

; Ferreira Borba, Eduardo

; Costallat, Lilian

; Xavier, Ricardo

; Tavares Brenol, Joao C.

; Da Silva, Nilzio A.

; Cavalcanti, Fernando

; Massardo, Loreto

; Jacobelli, Sergio

; Neira, Oscar

; Molina, José F

; Vásquez, Gloria

; Gómez-Puerta, José A.

; Alonso Gonzalez, Luis

; Iglesias Gamarra, Antonio

; Guibert-Toledano, Marlene

; Reyes, Gil A.

; Cardiel, Mario H.

; Pascual-Ramos, Virginia

; García de la Torre, Ignacio

; Barile, Leonor

; Silveira, Luis H.

; Amigo, Mary-Carmen

; Sauza del Pozo, María Josefina

; Acevedo-Vásquez, Eduardo M.

; Alfaro-Lozano, José

; Segami, María Inés

; Chacón-Díaz, Rosa

; Abadi, Isaac

; Esteva Spinetti, María H

; Pons-Estel, Bernardo A.

Revista argentina de reumatología

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sep 2018, Volume 29 N. 3 Pages 6 - 10

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

Objective: To assess the effects of antimalarials (AM) over the items of the SLICC Damage Index (SDI). Methods: Patients with recent (≤2 years) diagnosis of systemic lupus erythematosus (SLE) from the GLADEL cohort were studied. End-point: increase in items SDI since cohort entry. Independent variables (socio-demographic, clinical, laboratory and treatment) were included. The effect of AM as a time dependent variable on most frequent SDI items (adjusting for potential confounders) was examined with a multivariable Cox regression model. Results: Of the 1466 patients included in this analysis, 1049 (72%) received AM with a median exposure time of 30 months (Q1-Q3: 11-57). Damage occurred in 665 (45%) patients during a median follow-up time of 24 months (Q1-Q3: 8-55). There were 301 integument, 208 renal, 149 neuropsychiatric, 98 musculoskeletal, 88 cardiovascular and 230 others less frequently represented damages. After adjusting for potential confounders at any time during follow-up, a lower risk of renal damage (HR 0.652; 95% CI: 0.472-0.901) and borderline for neuropsychiatric damage (HR 0.701, 95% CI: 0.481-1.024) was found. Conclusion: In the GLADEL cohort, after adjustment for possible confounding factors, AM were independently associated with a reduced risk of renal damage accrual.

Objetivos: Estimar el efecto de los antimaláricos (AM) sobre los diferentes dominios del índice de daño SLICC (SDI). Métodos: Se estudiaron pacientes con diagnóstico clínico reciente (≤2 años) de lupus eritematoso sistémico (LES) de la cohorte GLADEL. Variable de estudio: aumento en los dominios del SDI desde el ingreso a la cohorte. Variables independientes: características sociodemográficas, clínicas, laboratorio y tratamientos. El efecto de los AM, como variable dependiente del tiempo, sobre los dominios más frecuentes del SDI (ajustado por factores de confusión) fue examinado con un modelo de regresión de Cox multivariado. Resultados: De 1466 pacientes estudiados, 1049 (72%) recibieron AM con un tiempo medio de exposición de 30 meses (Q1-Q3: 11-57) y 665 pacientes (45%) presentaron daño durante un seguimiento medio de 24 meses (Q1-Q3: 8-55); 301 eventos fueron cutáneos, 208 renales, 149 neuropsiquiátricos, 98 musculoesqueléticos, 88 cardiovasculares y 230 otros. Después de ajustar por factores de confusión, el uso de AM se asoció a un menor riesgo de daño renal (HR 0,652; IC 95%: 0,472-0,901) y en el límite de la significancia estadística (HR 0,701, IC 95%: 0,481-1,024) para el dominio neuropsiquiátrico. Conclusión: En GLADEL, el uso de AM se asoció independientemente a un menor riesgo de daño acumulado renal.

162 downloads

12.

Factors associated with the prevalence of helminths in Mangalarga Marchador horses in southern of Minas Gerais, Brazil
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Rosa, Marina H.F.

; Garcia, Adriana M.

; Daher, Débora O.

; Lima, Imara G.

; Félix, Marcelle B.

; Capellari, Luiz A.

; Ferreira, Fernando

; Rocha, Christiane M.B.M.

Pesquisa Veterinária Brasileira

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jun 2018, Volume 38 N. 6 Pages 1097 - 1104

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO: Os equinos são animais muito susceptíveis ao parasitismo. As helmintoses causam grandes prejuízos tanto para os animais, quanto para os criadores. Este estudo teve como objetivo avaliar os fatores sócio-econômicos-culturais e de manejo associados à prevalência de helmintos gastrointestinais de equinos. Foram visitados 40 criatórios de equinos Mangalarga Marchador no Sul de Minas Gerais, nos quais foram realizadas entrevistas. Foram coletadas fezes dos animais nas propriedades e realizados exames laboratoriais coproparasitológicos a fim de quantificar a infecção dos animais e identificar os parasitos. Os dados foram tabulados no Epidata e analisados no software SPSS 20.0. Observou-se uma grande semelhança no perfil dos criadores, assim como na caracterização da propriedade, manejo e controle de parasitos. Os ciatostomíneos foram os helmintos mais prevalentes, seguidos pelo Oxyuris e os grandes estrôngilos. As propriedades que priorizam a equinocultura têm menor chance de apresentar animais com infecção maciça.

ABSTRACT: Horses are highly susceptible to parasitism. Helminth infections cause great harm to the animals and to their breeders. This study aimed at evaluating socioeconomic, cultural and management factors associated with the prevalence of gastrointestinal helminths of horses. A total of 40 farmas the Mangalarga Marchador horse breed were visited in southern Minas Gerais, Brazil, where interviews were conducted. Horse feces were collected on the farms and coproparasitological laboratory tests were conducted to quantify the infection and to identify parasites. Data were tabulated in Epidata and analyzed using the SPSS 20.0 software. A great similarity between breeds was observed, specifically in their profiles, as well as in their animal management techniques and in their parasite control habits. The cyathostome was the most prevalent helminth, followed by Oxyuris and large strongyles. The farms which prioritize only equine production are less likely to have animals with massive helminth infection.

https://doi.org/10.1590/1678-5150-pvb-5177 1272 downloads

13.

Time-course of health-related adaptations in response to combined training in hypertensive elderly: immune and autonomic modulation interactions
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Sardeli, Amanda V.

; Gáspari, Arthur F.

; Santos, Wellington M. dos

; Moraes, Daisa Fabiele G.

; Gadelha, Victor B.

; Santos, Lucas do C.

; Ferreira, Marina Lívia V.

; Prudêncio, Simara Maria de J.

; Bonfante, Ivan Luiz P.

; Rodrigues, Bruno

; Cavaglieri, Cláudia Regina

; Fernhall, Bo

; Chacon-Mikahil, Mara Patrícia T.

Motriz: Revista de Educação Física

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2018, Volume 24 N. 4 elocation e101866

Abstract: En | Text: En | PDF: En

Abstract Aims: This article is a methodological description of a randomized clinical trial (ClinicalTrials.gov U1111-1181-4455) aiming to evaluate the time-course (monthly) and associations between blood pressure changes and other health-related adaptations in response to exercise training in hypertensive elderly. Methods: The patients will be randomized to a control or combined training group interventions (aerobic and resistance exercise), with monthly assessments in four months. Although, the changes in baseline blood pressure is the primary clinical outcome, the secondary outcomes include: body composition, cardiorespiratory fitness, muscle strength, arterial stiffness, baroreceptor sensitivity, cardiovascular autonomic modulation, inflammatory markers, oxidative stress, growth factors, tissue remodeling markers, metabolic profile, renal function, cognitive function and quality of life. Results: To support the understanding of the blood pressure changes in hypertensive elderly, a time-course of exercise-induced adaptations including cardiovascular and immunological adaptations are fundamental for research in this field. Conclusion: To investigate the time-course of combined training-induced adaptations including all the diverse aspects of health in hypertensive elderly a well-controlled protocol design is necessary, mainly to clarify the relationship between cardiovascular and immunological exercise-induced adaptations.

https://doi.org/10.1590/s1980-6574201800040007 1055 downloads

14.

Resistance training and hormone replacement increase MMP-2 activity, quality and quantity of bone in ovariectomized rats
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Souza, Markus V.C

; Lino, Anderson D. S

; Ruffoni, Leandro G. D

; Domingos, Mateus M.

; Barbosa, Marina R.

; Rodrigues, Maria F C.

; Ferreira, Fabiano C.

; Tomaz, Luciane M.

; Canevazzi, Gustavo H. R.

; Silva, Natália S.

; Teixeira, Jeferson A. A.

; Leite, Richard D.

; Shiguemoto, Gilberto E.

; Perez, Sérgio E. A.

Motriz: Revista de Educação Física

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2017, Volume 23 N. 4 elocation e1017107

Abstract: En | Text: En | PDF: En

Abstract AIMS The aim of the present study was to investigate the influence of resistance training (RT) and hormone replacement (HR) on MMP-2 activity, biomechanical and physical properties bone of ovariectomized (OVX) rats. METHODS Sprague-Dawley female rats were grouped into six experimental groups (n = 11 per group): sham-operated sedentary (SHAM Sed), ovariectomized sedentary (OVX Sed), sham-operated resistance training (SHAM RT), ovariectomized resistance training (OVX RT), ovariectomized sedentary hormone replacement (OVX Sed-HR), and ovariectomized resistance training hormone replacement (OVX RT-HR). HR groups received implanted silastic capsules with a 5% solution of 17β-estradiol (50 mg 17β-estradiol/ml of sunflower oil). In a 12-week RT period (27 sessions; 4-9 climbs) the animals climbed a 1.1 m vertical ladder with weights attached to their tails. Biomechanical and physical bone analyses were performed using a universal testing machine, and MMP-2 activity analysis was done by zymography. RESULTS Bone density and bone mineral content was higher in the RT and HR groups. The MMP-2 activity was higher in the RT and HR groups. The biomechanical analysis (stiffness, fracture load and maximum load) demonstrated better bone tissue quality in the RT associated with HR. CONCLUSION The RT alone as well as when it is associated with HR was efficient in increasing MMP-2 activity, biomechanical and biophysical properties bone of ovariectomized rats.

https://doi.org/10.1590/s1980-6574201700040003 751 downloads

15.

Reliability of the Brazilian Portuguese version of the Gross Motor Function Measure in children with cerebral palsy
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Almeida, Kênnea M.

; Albuquerque, Karolina A.

; Ferreira, Marina L.

; Aguiar, Stéphany K. B.

; Mancini, Marisa C.

Brazilian Journal of Physical Therapy

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feb 2016, Volume 20 N. 1 Pages 73 - 80

Abstract: En | Text: En | PDF: En

OBJECTIVE: To test the intra- and interrater reliability of the Brazilian Portuguese version of the 66-item Gross Motor Function Measure (GMFM-66). METHOD: The sample included 48 children with cerebral palsy (CP), ranging from 2-17 years old, classified at levels I to IV of the Gross Motor Function Classification System (GMFCS) and four child rehabilitation examiners. A main examiner evaluated all children using the GMFM-66 and video-recorded the assessments. The other examiners watched the video recordings and scored them independently for the assessment of interrater reliability. For the intrarater reliability evaluation, the main examiner watched the video recordings one month after the evaluation and re-scored each child. We calculated reliability by using intraclass correlation coefficients (ICC) with their respective 95% confidence intervals. RESULTS: Excellent test reliability was documented. The intrarater reliability of the total sample was ICC=0.99 (95% CI 0.98-0.99), and the interrater reliability was ICC=0.97 (95% CI 0.95-0.98). The reliability across GMFCS levels ranged from ICC=0.92 (95% CI 0.72-0.98) to ICC=0.99 (95% CI 0.99-0.99); the lowest value was the interrater reliability for the GMFCS IV group. Reliability in the five GMFM dimensions varied from ICC=0.95 (95% CI 0.93-0.97) to ICC=0.99 (95% CI 0.99-0.99). CONCLUSION: The Brazilian Portuguese version of the GMFM-66 showed excellent intra- and interrater reliability when used in Brazilian children with CP levels GMFCS I to IV.

https://doi.org/10.1590/bjpt-rbf.2014.0131 2464 downloads

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