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Fixed and on-demand regimens of acetaminophen in periodontal surgery: randomized clinical trial ondemand on demand surgery
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Piardi, Carla Cioato

; Vaz, Cristiane Galli

; Ferreira, Maria Beatriz Cardoso

; Pilger, Diogo

; Fernandes, Marilene Issa

; Weidlich, Patrícia

Brazilian Journal of Oral Sciences

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2023, Volume 22 elocation e238329

Abstract: En | Text: En | PDF: En

Aim to evaluate the clinical efficacy of an acetaminophen analgesic by comparing its prescription in fixed versus on-demand schedules after periodontal surgery. The hypothesis of the study was that the fixed regimen would be more effective than the on-demand regimen for postoperative analgesics following periodontal surgery. Methods An open randomized clinical trial was conducted. The 68 patients who needed total flap surgery to restore supracrestal tissue attachment or surgical treatment of periodontitis were randomized”. Visual Analogue Scale was used to assess pain. The fixed group (n = 34) received 500 mg of acetaminophen every 4 hours for 2 days. The on-demand group (n = 34) was instructed to use the acetaminophen “as needed,” at intervals of no less than 4 hours between doses. Ibuprofen was the rescue medication for both groups. Pain scores and medication use were recorded 2, 6, 12, 24 and 48 hours after the surgical procedure. The study was registered at the Brazilian Registry of Clinical Trials under RBR-7wv259. Results The two groups did not differ in relation to the frequency or the intensity of pain in a 48-hour period (n=20 in the fixed group, and n=22 in the on-demand group), or even in the intention-to-treat (n=34 in each group). Individuals who experienced moderate to severe pain used rescue medication more frequently in both groups. No adverse events were reported. Conclusion Both regimens were effective in controlling postoperative pain after periodontal surgery. ondemand on demand conducted 6 randomized. . randomized” n 34 50 days as needed, doses 12 procedure RBR7wv259. RBR7wv259 RBRwv RBR 7wv259. 7wv259 wv RBR-7wv259 48hour hour n=20 n20 20 (n=2 n22 22 n=2 , group) intentiontotreat intention treat n=34 n34 (n=3 group. reported 3 5 1 RBR7wv25 7wv25 RBR-7wv25 n2 (n= n= n=3 n3 RBR7wv2 7wv2 RBR-7wv2 RBR7wv 7wv RBR-7wv

https://doi.org/10.20396/bjos.v22i00.8668329

IMPACTO-MR: um estudo brasileiro de plataforma nacional para avaliar infecções e multirresistência em unidades de terapia intensiva IMPACTOMR IMPACTO MR IMPACTO-MR
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Tomazini, Bruno M

; Nassar Jr, Antonio Paulo

; Lisboa, Thiago Costa

; Azevedo, Luciano César Pontes de

; Veiga, Viviane Cordeiro

; Catarino, Daniela Ghidetti Mangas

; Fogazzi, Debora Vacaro

; Arns, Beatriz

; Piastrelli, Filipe Teixeira

; Dietrich, Camila

; Negrelli, Karina Leal Jesuíno, Isabella de Andrade Reis, Luiz Fernando Lima Mattos, Renata Rodrigues de Pinheiro, Carla Cristina Gomes Luz, Mariane Nascimento Spadoni, Clayse Carla da Silva Moro, Elisângela Emilene Bueno, Flávia Regina Sampaio, Camila Santana Justo Cintra Silva, Débora Patrício Baldassare, Franca Pellison Silva, Ana Cecilia Alcantara Veiga, Thabata Barbante, Leticia Lambauer, Marianne Campos, Viviane Bezerra Santos, Elton Santos, Renato Hideo Nakawaga Laranjeiras, Ligia Nasi Valeis, Nanci Santucci, Eliana Miranda, Tamiris Abait Patrocínio, Ana Cristina Lagoeiro do Carvalho, Andréa de Sousa, Eduvirgens Maria Couto de Sousa, Ancelmo Honorato Ferraz de Malheiro, Daniel Tavares Bezerra, Isabella Lott Rodrigues, Mirian Batista Malicia, Julliana Chicuta Silva, Sabrina Souza da Gimenes, Bruna dos Passos Sesin, Guilhermo Prates Zavascki, Alexandre Prehn Sganzerla, Daniel Medeiros, Gregory Saraiva Santos, Rosa da Rosa Minho dos Silva, Fernanda Kelly Romeiro Cheno, Maysa Yukari Abrahão, Carolinne Ferreira Oliveira Junior, Haliton Alves de Rocha, Leonardo Lima Nunes Neto, Pedro Aniceto Pereira, Valéria Chagas Paciência, Luis Eduardo Miranda Bueno, Elaine Silva Caser, Eliana Bernadete Ribeiro, Larissa Zuqui Fernandes, Caio Cesar Ferreira Garcia, Juliana Mazzei Silva, Vanildes de Fátima Fernandes Santos, Alisson Junior dos Machado, Flávia Ribeiro Souza, Maria Aparecida de Ferronato, Bianca Ramos Urbano, Hugo Corrêa de Andrade Moreira, Danielle Conceição Aparecida Souza-Dantas, Vicente Cés de Duarte, Diego Meireles Coelho, Juliana Figueiredo, Rodrigo Cruvinel Foreque, Fernanda Romano, Thiago Gomes Cubos, Daniel Spirale, Vladimir Miguel Nogueira, Roberta Schiavon Maia, Israel Silva Zandonai, Cassio Luis Lovato, Wilson José Cerantola, Rodrigo Barbosa Toledo, Tatiana Gozzi Pancev Tomba, Pablo Oscar Almeida, Joyce Ramos de Sanches, Luciana Coelho Pierini, Leticia Cunha, Mariana Sousa, Michelle Tereza Azevedo, Bruna Dal-Pizzol, Felipe Damasio, Danusa de Castro Bainy, Marina Peres Beduhn, Dagoberta Alves Vieira Jatobá, Joana D’Arc Vila Nova Moura, Maria Tereza Farias de Rego, Leila Rezegue de Moraes Silva, Adria Vanessa da Oliveira, Luana Pontes Sodré Filho, Eliene Sá Santos, Silvana Soares dos Neves, Itallo de Lima Leão, Vanessa Cristina de Aquino Paes, João Lucidio Lobato Silva, Marielle Cristina Mendes Oliveira, Cláudio Dornas de Santiago, Raquel Caldeira Brant Paranhos, Jorge Luiz da Rocha Wiermann, Iany Grinezia da Silva Pedroso, Durval Ferreira Fonseca Sawada, Priscilla Yoshiko Prestes, Rejane Martins Nascimento, Glícia Cardoso Grion, Cintia Magalhães Carvalho Carrilho, Claudia Maria Dantas de Maio Dantas, Roberta Lacerda Almeida de Miranda Silva, Eliane Pereira Silva, Antônio Carlos da Oliveira, Sheila Mara Bezerra de Golin, Nicole Alberti Tregnago, Rogerio Lima, Valéria Paes Silva, Kamilla Grasielle Nunes da Boschi, Emerson Buffon, Viviane Machado, André Sant’Ana Capeletti, Leticia Foernges, Rafael Botelho Carvalho, Andréia Schubert de Oliveira Junior, Lúcio Couto de Oliveira, Daniela Cunha de Silva, Everton Macêdo Ribeiro, Julival Pereira, Francielle Constantino Salgado, Fernanda Borges Deutschendorf, Caroline Silva, Cristofer Farias da Gobatto, Andre Luiz Nunes Oliveira, Carolaine Bomfim de Dracoulakis, Marianna Deway Andrade Alvaia, Natália Oliveira Santos Souza, Roberta Machado de Araújo, Larissa Liz Cardoso de Melo, Rodrigo Morel Vieira de Passos, Luiz Carlos Santana Vidal, Claudia Fernanda de Lacerda Rodrigues, Fernanda Lopes de Albuquerque Kurtz, Pedro Shinotsuka, Cássia Righy Tavares, Maria Brandão Santana, Igor das Virgens Gavinho, Luciana Macedo da Silva Nascimento, Alaís Brito Pereira, Adriano J Cavalcanti, Alexandre Biasi

Revista Brasileira de Terapia Intensiva

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dec 2022, Volume 34 N. 4 Pages 418 - 425

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Objetivo: Descrever o IMPACTO-MR, um estudo brasileiro de plataforma nacional em unidades de terapia intensiva focado no impacto das infecções por bactérias multirresistentes relacionadas à assistência à saúde. Métodos: Descrevemos a plataforma IMPACTO-MR, seu desenvolvimento, critérios para seleção das unidades de terapia intensiva, caracterização da coleta de dados, objetivos e projetos de pesquisa futuros a serem realizados na plataforma. Resultados: Os dados principais foram coletados por meio do Epimed Monitor System® e consistiram em dados demográficos, dados de comorbidades, estado funcional, escores clínicos, diagnóstico de internação e diagnósticos secundários, dados laboratoriais, clínicos e microbiológicos e suporte de órgãos durante a internação na unidade de terapia intensiva, entre outros. De outubro de 2019 a dezembro de 2020, 33.983 pacientes de 51 unidades de terapia intensiva foram incluídos no banco de dados principal. Conclusão: A plataforma IMPACTO-MR é um banco de dados clínico brasileiro de unidades de terapia intensiva focado na pesquisa do impacto das infecções por bactérias multirresistentes relacionadas à assistência à saúde. Essa plataforma fornece dados para o desenvolvimento e pesquisa de unidades de terapia intensiva individuais e ensaios clínicos observacionais e prospectivos multicêntricos. Objetivo IMPACTOMR, IMPACTOMR IMPACTO MR, MR saúde Métodos Resultados System demográficos comorbidades funcional secundários laboratoriais outros 201 2020 33983 33 983 33.98 5 principal Conclusão multicêntricos 20 202 3398 3 98 33.9 2 339 9 33.

ABSTRACT Objective: To describe the IMPACTO-MR, a Brazilian nationwide intensive care unit platform study focused on the impact of health care-associated infections due to multidrug-resistant bacteria. Methods: We described the IMPACTO-MR platform, its development, criteria for intensive care unit selection, characterization of core data collection, objectives, and future research projects to be held within the platform. Results: The core data were collected using the Epimed Monitor System® and consisted of demographic data, comorbidity data, functional status, clinical scores, admission diagnosis and secondary diagnoses, laboratory, clinical, and microbiological data, and organ support during intensive care unit stay, among others. From October 2019 to December 2020, 33,983 patients from 51 intensive care units were included in the core database. Conclusion: The IMPACTO-MR platform is a nationwide Brazilian intensive care unit clinical database focused on researching the impact of health care-associated infections due to multidrug-resistant bacteria. This platform provides data for individual intensive care unit development and research and multicenter observational and prospective trials. Objective IMPACTOMR, IMPACTOMR IMPACTO MR, MR careassociated associated multidrugresistant multidrug resistant bacteria Methods selection collection objectives Results System status scores diagnoses laboratory stay others 201 2020 33983 33 983 33,98 5 Conclusion trials 20 202 3398 3 98 33,9 2 339 9 33,

https://doi.org/10.5935/0103-507x.20220209-pt

Characteristics and outcomes of patients with COVID-19 admitted to the ICU in a university hospital in São Paulo, Brazil - study protocol
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Ferreira, Juliana C.

; Ho, Yeh-Li

; Besen, Bruno A.M.P.

; Malbuisson, Luiz M.S.

; Taniguchi, Leandro U.

; Mendes, Pedro V.

; Costa, Eduardo L.V.

; Park, Marcelo

; Daltro-Oliveira, Renato

; Roepke, Roberta M.L.

; Silva Jr, João M.

; Carmona, Maria José C.

; Carvalho, Carlos Roberto Ribeiro

; Hirota, Adriana Kanasiro, Alberto Kendy Crescenzi, Alessandra Fernandes, Amanda Coelho Miethke-Morais, Anna Bellintani, Arthur Petrillo Canasiro, Artur Ribeiro Carneiro, Bárbara Vieira Zanbon, Beatriz Keiko Batista, Bernardo Pinheiro De Senna Nogueira Nicolao, Bianca Ruiz Besen, Bruno Adler Maccagnan Pinheiro Biselli, Bruno Macedo, Bruno Rocha De Toledo, Caio Machado Gomes De Pompilio, Carlos Eduardo Carvalho, Carlos Roberto Ribeiro De Mol, Caroline Gomes Stipanich, Cassio Bueno, Caue Gasparotto Garzillo, Cibele Tanaka, Clarice Forte, Daniel Neves Joelsons, Daniel Robira, Daniele Costa, Eduardo Leite Vieira Silva Júnior, Elson Mendes Da Regalio, Fabiane Aliotti Segura, Gabriela Cardoso Marcelino, Gustavo Brasil Louro, Giulia Sefrin Ho, Yeh-Li Ferreira, Isabela Argollo Gois, Jeison de Oliveira Silva Junior, Joao Manoel Da Reusing Junior, Jose Otto Ribeiro, Julia Fray Ferreira, Juliana Carvalho Galleti, Karine Vusberg Silva, Katia Regina Isensee, Larissa Padrao Oliveira, Larissa dos Santos Taniguchi, Leandro Utino Letaif, Leila Suemi Lima, Lígia Trombetta Park, Lucas Yongsoo Chaves Netto, Lucas Nobrega, Luciana Cassimiro Haddad, Luciana Hajjar, Ludhmila Malbouisson, Luiz Marcelo Pandolfi, Manuela Cristina Adsuara Park, Marcelo Carmona, Maria José Carvalho Andrade, Maria Castilho Prandini H De Santos, Mariana Moreira Bateloche, Matheus Pereira Suiama, Mayra Akimi Oliveira, Mayron Faria de Sousa, Mayson Laercio Louvaes, Michelle Huemer, Natassja Mendes, Pedro Lins, Paulo Ricardo Gessolo Santos, Pedro Gaspar Dos Moreira, Pedro Ferreira Paiva Guazzelli, Renata Mello Reis, Renato Batista Dos Oliveira, Renato Daltro De Roepke, Roberta Muriel Longo Pedro, Rodolpho Augusto De Moura Kondo, Rodrigo Rached, Samia Zahi Fonseca, Sergio Roberto Silveira Da Borges, Thais Sousa Ferreira, Thalissa Cobello Junior, Vilson Sales, Vivian Vieira Tenório Ferreira, Willaby Serafim Cassa

Clinics

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2020, Volume 75 elocation e2294

Abstract: En | Text: En | PDF: En

OBJECTIVES: We designed a cohort study to describe characteristics and outcomes of patients with coronavirus disease (COVID-19) admitted to the intensive care unit (ICU) in the largest public hospital in Sao Paulo, Brazil, as Latin America becomes the epicenter of the pandemic. METHODS: This is the protocol for a study being conducted at an academic hospital in Brazil with 300 adult ICU beds dedicated to COVID-19 patients. We will include adult patients admitted to the ICU with suspected or confirmed COVID-19 during the study period. The main outcome is ICU survival at 28 days. Data will be collected prospectively and retrospectively by trained investigators from the hospital’s electronic medical records, using an electronic data capture tool. We will collect data on demographics, comorbidities, severity of disease, and laboratorial test results at admission. Information on the need for advanced life support and ventilator parameters will be collected during ICU stay. Patients will be followed up for 28 days in the ICU and 60 days in the hospital. We will plot Kaplan-Meier curves to estimate ICU and hospital survival and perform survival analysis using the Cox proportional hazards model to identify the main risk factors for mortality. ClinicalTrials.gov: NCT04378582. RESULTS: We expect to include a large sample of patients with COVID-19 admitted to the ICU and to be able to provide data on admission characteristics, use of advanced life support, ICU survival at 28 days, and hospital survival at 60 days. CONCLUSIONS: This study will provide epidemiological data about critically ill patients with COVID-19 in Brazil, which could inform health policy and resource allocation in low- and middle-income countries.

https://doi.org/10.6061/clinics/2020/e2294 1957 downloads

Fitossociologia de um fragmento de restinga herbáceo-subarbustiva no sul do Estado de Santa Catarina, Brasil
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Schlickmann, Monique Bohora

; Ferreira, Maria Eduarda Alves Varela, Elaine Puziski Pereira, Jader Lima Duarte, Edilaine Luz, Ana Paula Cardoso da Dreyer, Jaqueline Beatriz Brixner Silva, Maycon Thuan Saturnino da Pinto, Felipe Mateus

Hoehnea

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2019, Volume 46 N. 2 elocation e292018

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO A vegetação de restinga é uma formação típica de ecossistemas costeiros de alta relevância ecológica. Dessa forma, o objetivo do estudo foi descrever a composição florística e estrutural de um fragmento de restinga herbáceo-subarbustiva localizada em Balneário Esplanada, no município de Jaguaruna, sul do Estado de Santa Catarina. Foram instaladas 20 parcelas de 4 m2 equidistantes quatro metros entre si, totalizando 80 m2 de área amostral. A cobertura de cada espécie foi estimada pela escala de Causton. Foram amostrados 90 indivíduos distribuídos em 13 famílias botânicas, 21 gêneros e 21 espécies. As famílias com maior riqueza foram Asteraceae, Poaceae, Boraginaceae e Solanaceae. As espécies mais frequentes foram Panicum racemosum e Hydrocotyle bonariensis, com VI igual a 37,5 e 23,5, respectivamente. Para a estrutura comunitária houve sete classes de altura, sendo os primeiros estratos os mais ricos e a classe 1 com o maior número de espécies. A diversidade de Shannon e equabilidade de Pielou foram 2,67 e 0,59, respectivamente.

ABSTRACT The sandbank vegetation is a typical coastal ecosystem with a high ecological importance. The objective of this study was to describe the floristic and structural composition of an herbaceous sub shrub Restinga fragment located in Balneário Esplanada, municipality of Jaguaruna, in the south of Santa Catarina State. Twenty plots of 4m2 equally spaced four meters from each other were installed, totaling 80m2 of sampled area. The coverage of each species was estimated by the Causton scale. Ninety individuals of 13 botanical families, 21 genera and 21 species were sampled. The richest families were Asteracae, Poaceae, Boraginaceae and Solanaceae. The most predominant species were Panicum racemosum and Hydrocotyle bonariensis, with VI equal to 37.5 and 23.5, respectively. Within the community structure, there were seven height classes, the first strata being the richest, and the class 1 with the largest number of species. The diversity of Shannon and Pielou equability were 2.67 and 0.59, respectively.

https://doi.org/10.1590/2236-8906-29/2018 1353 downloads

Possibilities of care for serodiscordant couples for HIV who got pregnant
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Langendorf, Tassiane Ferreira Souza, Ivis Emília de Oliveira Padoin, Stela Maris de Mello Paula, Cristiane Cardoso de Queiroz, Ana Beatriz Azevedo Moura, Maria Aparecida Vasconcelos Melo, Maria Carmen Simões Cardoso de Silva, Lúcia de Fatima da

Revista Brasileira de Enfermagem

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dec 2017, Volume 70 N. 6 Pages 1199 - 1205

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

RESUMO Objetivo: Compreender o significado da gestação para casais heterossexuais diante da situação de sorodiscordância para o HIV com vistas à construção de possibilidades de cuidado fundadas na subjetividade. Método: Investigação fenomenológica, referencial teórico-filosófico-metodológico de Martin Heidegger. Foi desenvolvida em um Hospital Universitário no interior do Sul do Brasil entre setembro de 2013 a maio de 2014 por meio de entrevista fenomenológica, da qual participaram 11 casais. Resultados: Para os casais, a gestação faz parte do seu vivido quando têm vontade, desejam e querem ter o filho do casal, mesmo quando um ou ambos já têm filhos de relacionamentos anteriores. Também faz parte quando consideram os riscos e não querem mais ter filhos nessas circunstâncias, mas de forma inesperada isso aconteceu. Conclusão: Compreender as necessidades e demandas reprodutivas desses casais se mostra como subsídio para a qualificação e aprimoramento da atenção como contribuição para o planejamento dos cuidados de enfermagem à saúde reprodutiva desse casal.

ABSTRACT Objective: Understanding the meaning of pregnancy for heterosexual couples facing serodiscordant situation for HIV, aiming at construction of care possibilities based on subjectivity. Method: Phenomenological research, theoretical-philosophical-methodological framework by Martin Heidegger. Research was conducted in a University Hospital in the countryside of Southern Brazil, from September 2013 to May 2014 through a phenomenological interview, with participation of eleven couples. Results: For the couples, pregnancy is part of life when they wish to have a child, even when one or both of them already have children from previous relationships. In addition, it is part of life when they consider the risks and do not want to have children in such circumstances anymore, but it happened unexpectedly. Conclusion: Understanding reproductive needs and demands of these couples is an aid for qualification and improvement of care as a contribution to nursing care planning towards reproductive health of these couples.

RESUMEN Objetivo: Comprender el significado del embarazo para las parejas heterosexuales serodiscordantes al VIH con el propósito de establecer cuidados basados en la subjetividad. Método: Estudio fenomenológico, de referencial teórico, filosófico, metodológico heideggeriano. Se empleó entrevista fenomenológica a once parejas participantes del estudio en el Hospital Universitario de una ciudad en la región Sur de Brasil en el periodo de septiembre de 2013 a mayo de 2014. Resultados: Para las parejas el embarazo forma parte de sus experiencias, ya sea porque desean tener hijos con el/la compañero/a, incluso si uno o ambos ya tienen hijos provenientes de relación anterior. Asimismo forma parte al considerar los riesgos y no desean tener más hijos en estas circunstancias, pero ocurre lo inesperado al quedarse embarazada. Conclusión: Comprender las necesidades y demandas reproductivas de estas parejas es importante para la calificación, el mejoramiento de los cuidados y la planificación de la asistencia ofrecida por el personal de enfermería a la salud reproductiva de estas personas.

https://doi.org/10.1590/0034-7167-2016-0344 3719 downloads

Possibilities of care for serodiscordant couples for HIV who got pregnant
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Revista Brasileira de Enfermagem

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dec 2017, Volume 70 N. 6 Pages 1199 - 1205

Abstract: En Es Pt | Text: En Es Pt | PDF: En | PDF: Es | PDF: Pt

https://doi.org/10.1590/0034-7167-2016-0344 14 downloads

Comparison of two combinations of opioid and non-opioid analgesics for acute periradicular abscess: a randomized clinical trial
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Santini, Manuela Favarin Rosa, Ricardo Abreu da Ferreira, Maria Beatriz Cardoso Fischer, Maria Isabel Souza, Erick Miranda Só, Marcus Vinícius Reis

Journal of Applied Oral Science

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oct 2017, Volume 25 N. 5 Pages 551 - 558

Abstract: En | Text: En | PDF: En

Abstract Acute periradicular abscess is a condition characterized by the formation and propagation of pus in the periapical tissues and generally associated with debilitating pain. Objective: The aim of this study was to compare the overall analgesic effectiveness of two combinations of opioid and non-opioid analgesics for acute periradicular abscess. Material and Methods: This study included 26 patients who sought emergency care in a Brazilian dental school. The patients were randomly divided into two groups: Co/Ac - oral prescription of codeine (30 mg) plus acetaminophen (500 mg), every 4 h, for 3 days or Tr/Ac - oral prescription of tramadol hydrochloride (37.5 mg) plus acetaminophen (500 mg) on the same schedule. Two factors were evaluated: (1) pain scores recorded by the patients in a pain diary 6, 12, 24, 48, and 72 h after treatment, using the Visual Analogue Scale; and (2) the occurrence of adverse effects. Results: In both groups, there was a reduction in pain scores over time. For the Co/Ac group, there was a significant reduction in the scores 12, 24, 48, and 72 hours after treatment (P<0.05). In the Tr/Ac group, the scores significantly decreased over time from time point 6 h (P<0.05). Comparing the pain at each time point, the groups were not significantly different (P>0.05), i.e., both treatments were effective in controlling pain caused by APA; however, the combination of Tr/Ac caused more adverse reactions as two patients had to stop using the medication. Conclusion: This study suggests that, considering both analgesic efficacy and safety, the combination of codeine and acetaminophen is more effective to control moderate to severe pain from acute periradicular abscesses.

https://doi.org/10.1590/1678-7757-2016-0407 3550 downloads

Saliva, supragingival biofilm and root canals can harbor gene associated with resistance to lactamic agents
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MORAES, Ludmila Coutinho FATTURI-PAROLO, Clarissa Cavalcanti FERREIRA, Maria Beatriz Cardoso SÓ, Marcus Vinicius Reis MONTAGNER, Francisco

Brazilian Oral Research

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2015, Volume 29 N. 1 Pages 1 - 6

Abstract: En | Text: En | PDF: En

This study aimed to determine the presence of Prevotella strains and genes associated with resistance to lactamics in different oral niches from patients with/without primary endodontic infections. Saliva (S) and supragingival biofilm (SB) were collected from three patient groups: Group I – no endodontic infection (n = 15); Group II – acute endodontic infection (n = 12); and Group III – chronic endodontic infection (n = 15). Root canal (RC) samples were collected from Groups II and III. The presence of P. intermedia, P nigrescens, P. tannerae and cfxA/cfxA2 gene was assessed by PCR. The cfxA/cfxA2 gene was not detected in all environments within the same patient. The cfxA/cfxA2 gene was present in 23.81% of S samples, 28.57% of SB samples, and 7.41% of RC samples. Prevotella species were detected in 53.97%, 47.62% and 34.56% of the S, SB, and RC samples, respectively. P. intermedia had a high frequency in saliva samples from Group 3. Saliva samples from Group 1 had higher detection rates of P. nigrescens than did Groups 2 and 3. Patients without endodontic disease had high frequencies of P. nigrescens in the SB samples. The presence or absence of spontaneous symptoms was not related to the detection rates for resistance genes in the RC samples. Saliva, supragingival biofilm and root canals can harbor resistant bacteria. The presence of symptomatology did not increase the presence of the cfxA/cfxA2 gene in the supragingival biofilm and inside root canals.

https://doi.org/10.1590/1807-3107BOR-2015.vol29.0052 1973 downloads

Effects of acute and chronic administration of methylprednisolone on oxidative stress in rat lungs
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Torres, Ronaldo Lopes Torres, Iraci Lucena da Silva Laste, Gabriela Ferreira, Maria Beatriz Cardoso Cardoso, Paulo Francisco Guerreiro Belló-Klein, Adriane

Jornal Brasileiro de Pneumologia

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jun 2014, Volume 40 N. 3 Pages 238 - 243

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Objetivo: Determinar os efeitos da administração aguda e crônica de metilprednisolona no estresse oxidativo, por meio da quantificação da peroxidação lipídica (POL) e do potencial antioxidante reativo total (PART), em pulmões de ratos. Métodos: Quarenta ratos Wistar foram divididos em quatro grupos: tratamento agudo, com ratos recebendo uma dose única de metilprednisolona (50 mg/kg i.p.); controle agudo, com ratos recebendo injeção unida de salina; tratamento crônico, com ratos recebendo metilprednisolona v.o. na água do bebedouro (6 mg/kg por dia durante 30 dias; e controle crônico, com ratos recebendo água de bebedouro normal). Resultados: Os níveis de PART foram significativamente maiores no grupo tratamento agudo que no grupo controle agudo, sugerindo uma melhora do sistema de defesa pulmonar. Os níveis de POL foram significativamente maiores no grupo tratamento crônico que no grupo controle crônico, indicando dano oxidativo no tecido pulmonar. Conclusões: Nossos resultados sugerem que o uso agudo de corticoides foi benéfico aos tecidos pulmonares, enquanto seu uso crônico não o foi. O uso crônico de metilprednisolona parece aumentar os níveis pulmonares da POL.

Objective: To determine the effects of acute and chronic administration of methylprednisolone on oxidative stress, as quantified by measuring lipid peroxidation (LPO) and total reactive antioxidant potential (TRAP), in rat lungs. Methods: Forty Wistar rats were divided into four groups: acute treatment, comprising rats receiving a single injection of methylprednisolone (50 mg/kg i.p.); acute control, comprising rats i.p. injected with saline; chronic treatment, comprising rats receiving methylprednisolone in drinking water (6 mg/kg per day for 30 days); and chronic control, comprising rats receiving normal drinking water. Results: The levels of TRAP were significantly higher in the acute treatment group rats than in the acute control rats, suggesting an improvement in the pulmonary defenses of the former. The levels of lung LPO were significantly higher in the chronic treatment group rats than in the chronic control rats, indicating oxidative damage in the lung tissue of the former. Conclusions: Our results suggest that the acute use of corticosteroids is beneficial to lung tissue, whereas their chronic use is not. The chronic use of methylprednisolone appears to increase lung LPO levels.

https://doi.org/10.1590/S1806-37132014000300006 3714 downloads

10.

Patient automedication and professional prescription pattern in an urgency service in Brazil
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DE-PAULA, Karen Barea SILVEIRA, Leonardo Spohr da FAGUNDES, Gabriela Xavier FERREIRA, Maria Beatriz Cardoso MONTAGNER, Francisco

Brazilian Oral Research

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2014, Volume 28 N. 1 Pages 1 - 6

Abstract: En | Text: En | PDF: En

Several studies have indicated an increased resistance of microorganisms resulting from the widespread use of antimicrobial agents. However, few data are available in the dental literature. The aim of this study was to conduct a survey on the patterns of patient usage of antimicrobial prescriptions agents by dentists. A retrospective cross-sectional study was based on the medical records of 223 patients who sought treatment at the Urgency Service, from a Dental School in the South of Brazil, from March 2009 to March 2011. A specific data sheet was used, with questions regarding: patient age and gender; the main complaint; medications used prior to the service; final diagnosis; proposed dental treatment (including prescription medications); and characteristics of the final prescription. Descriptive and inferential statistics were obtained. There was a high frequency of antibiotic use prior to attendance by young patients (Fisher’s exact test, p < 0.05). Toothache of endodontic origin was the most frequent patient complaint (72.6%). Endodontic procedures were the measures most frequently adopted to treat the pain (31.2%). The frequency of patient use of antimicrobials prior to the appointment was 14.3%. According to patient records, 83.9% had no systemic drug prescription after receiving urgency treatment. There were few antimicrobial prescriptions after the urgency treatment. The most frequently prescribed agents were amoxicillin, chlorhexidine, and metronidazole. Local measures were more frequently used than systemic approaches to treat urgencies of dental origin. Antimicrobial agents were not frequently prescribed as adjunctives to local administered at the urgency service.

https://doi.org/10.1590/1807-3107BOR-2014.vol28.0041 4304 downloads

11.

Rational use of medicines: prescribing indicators at different levels of health care
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Ferreira, Maria Beatriz Cardoso Heineck, Isabela Flores, Liziane Maahs Camargo, Aline Lins Dal Pizzol, Tatiane da Silva Torres, Iraci Lucena da Silva Koenig, Alvaro Trevisol, Daisson José Melo, Adriana Mary Mestriner Felipe de Cardoso, Teófilo Fernando Mazon Monreal, Maria Tereza Ferreira Duenhas Kadri, Mônica Cristina Toffoli

Brazilian Journal of Pharmaceutical Sciences

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jun 2013, Volume 49 N. 2 Pages 329 - 340

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Este estudo multicêntrico teve como objetivo investigar o padrão de prescrição de medicamentos para pacientes ambulatoriais atendidos em serviços de saúde vinculados a universidades com diferentes níveis de atenção, em oito cidades do sul e centro-oeste do Brasil. As prescrições coletadas foram submetidas à análise de diversos itens, incluindo os indicadores de prescrição propostos pela OMS. No total, 2.411 prescrições foram analisadas e 469 medicamentos foram identificados. O número de medicamentos prescritos por consulta, a frequência de polifarmácia e a porcentagem de consultas com pelo menos um medicamento injetável ou um antimicrobiano prescrito foram maiores em centros de saúde que ofereciam cuidados de atenção básica, em comparação com aqueles que não dispunham desse tipo de atendimento. A maioria dos medicamentos foi prescrita pelo nome genérico (86,1%). Em unidades com cuidados de atenção básica, a acessibilidade foi maior, a prescrição de medicamentos presentes nas Listas Nacional e Municipais de Medicamentos Essenciais foi mais frequente e instruções foram fornecidas aos pacientes mais comumente. Entretanto, advertências e medidas não farmacológicas foram indicadas com menor frequência. Este estudo revela tendências de prescrição de medicamentos em serviços de saúde ligados a universidades, com diferentes níveis de atenção, e indica possíveis áreas de melhoria na prática da prescrição.

This multicenter study aimed to investigate prescribing patterns of drugs at different levels of health care delivery in university-affiliated outpatient clinics located in eight cities in the South and Midwest of Brazil. All prescriptions collected were analyzed for various items, including WHO prescribing indicators. A total of 2,411 prescriptions were analyzed, and 469 drugs were identified. The number of drugs prescribed per encounter, the frequency of polypharmacy, and the percentage of encounters with at least one injection or antibiotic prescribed were higher in centers providing primary health care services, compared to those where this type of care is not provided. Most drugs (86.1%) were prescribed by generic name. In centers with primary health care services, drug availability was higher, drugs included in the National and Municipal Lists of Essential Medicines were more frequently prescribed, and patients were given more instructions. However, warnings and non-pharmacological measures were less frequently recommended. This study reveals trends in drug prescribing at different levels of health care delivery in university-affiliated outpatient clinics and indicates possible areas for improvement in prescribing practices.

11849 downloads

12.

Dispensações de psicotrópicos anorexígenos no município de Juiz de Fora, Minas Gerais, Brasil
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Martins, Eduardo Luiz Mendonça Amaral, Maria da Penha Henriques do Ferreira, Maria Beatriz Cardoso Mendonça, Alessandra Ésther de Pereira, Mônica Cecília Santana Pereira, Denise Campos Ribeiro, Paula Maria Brumano, Larissa Pereira

Ciência & Saúde Coletiva

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dec 2012, Volume 17 N. 12 Pages 3331 - 3342

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

A obesidade é um grave problema de saúde pública, com prevalência crescente em níveis epidêmicos. Tratamento farmacológico é uma das abordagens terapêuticas, mas deve ser precedido de mudança de hábitos alimentares e prática regular de atividades físicas. Há preocupação com o uso não racional de medicamentos anorexígenos, independente da condição de doença. O estudo avaliou as dispensações destes psicotrópicos realizadas em 2009, Juiz de Fora, MG. Realizou-se a pesquisa em boletins de consumo, enviados mensalmente à VISA municipal, e em registros obtidos no SNGPC. De 7.759 notificações pesquisadas, 93,3% foram dispensadas por farmácias magistrais e 6,7% por drogarias. Daquele total, 55,4% foram de anfepramona, 33,1% de femproporex e 11,5% de mazindol. Com base em relatório da Anvisa, as três substâncias apresentaram consumo maior no município (DDD/mil hab/ano) do que no país como um todo, para o mesmo período. O profissional com maior número de receitas aviadas teve 3.535 dispensações. Todas foram dispensadas em farmácias, sendo 99,5% em um único estabelecimento. O cenário mostra a dispensação de anorexígenos como problema relevante de saúde coletiva e indica a necessidade de reavaliação dos critérios de monitoramento de sua prescrição, dispensação e consumo.

Obesity is a serious public health issue of epidemic proportions. Although drug therapy is one of the therapeutic approaches, it should be preceded by a change in eating habits along with regular exercise. This study assessed prescription of such drugs in 2009, in Juiz de Fora, Minas Gerais, Brazil. Data were collected from consumption bulletins sent monthly to the municipal sanitary surveillance agency (VISA), and from the Brazilian National Management System of Controlled Products. Of the 7,759 notifications assessed, 93.3% were dispensed by prescription pharmacies and 6.7% by drugstores. Of that total, 55.4% were for amphepramone, 33.1% for femproporex, and 11.5% for mazindol. The three drugs had a larger consumption rate in the municipality (daily defined dose/1,000 inhabitants/day) than in the country as a whole, during the period under study. The professional with the highest prescription rate was responsible for 3,535 prescriptions. All of these were dispensed by prescription pharmacies, a single outlet being responsible for 99.5% of these prescriptions. This scenario shows that anorectic psychotropic drug prescription is a relevant public health issue and the criteria for monitoring the prescription and consumption of these drugs should be re-evaluated.

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13.

Dispensações de psicotrópicos anorexígenos no município de Juiz de Fora, Minas Gerais, Brasil
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dec 2012, Volume 17 N. 12 Pages 3331 - 3342

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

14.

Avaliação do impacto da exposição a agrotóxicos sobre a saúde de população rural: Vale do Taquari (RS, Brasil)
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Souza, Andressa de Medeiros, Afonso dos Reis Souza, Ana Cláudia de Wink, Márcia Siqueira, Ionara Rodrigues Ferreira, Maria Beatriz Cardoso Fernandes, Luciana Loayza Hidalgo, Maria Paz Torres, Iraci Lucena da Silva

Ciência & Saúde Coletiva

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aug 2011, Volume 16 N. 8 Pages 3519 - 3528

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Este estudo transversal teve o objetivo de avaliar possível associação entre contato com agrotóxicos e prevalência de doenças crônicas em população rural do Sul do Brasil. Três municípios foram aleatoriamente escolhidos. A amostra selecionada por conveniência foi recrutada durante três meses (2005) e se compôs de 298 sujeitos de ambos os sexos, com idade entre 18 e 65 anos e que procuravam farmácia pública ou privada para a compra de medicamentos. Os dados obtidos, mediante entrevistas estruturadas, demonstraram que 68,4% dos entrevistados exerciam atividade rural, dos quais 74,8% eram membros de famílias de agricultores e tinham contato com agrotóxicos. A média de idade foi 51±16,5 anos para os entrevistados com contato com agrotóxicos e 50±17,9 anos para os sem contato. A amostra foi constituída de 36,2% por homens e 57,7% dos indivíduos que apresentavam mais de quatro anos de estudo. O contato direto ou indireto com agrotóxicos associou-se ao relato de várias doenças, sendo as neurológicas e as orais as mais prevalentes. Houve associação com relato de condições dolorosas, de modo que indivíduos com contato com agrotóxicos apresentaram em torno de duas vezes mais chances de as referirem. Os dados corroboram os da literatura e indicam a necessidade de promoção de medidas de proteção e prevenção da saúde da população rural.

The scope of this cross-sectional study was to assess a possible link between contact with pesticides and the prevalence of chronic disease in the rural population in the south of Brazil. Three municipalities were randomly chosen. The sample selected was recruited over three months (2005) and was composed of 298 subjects of both sexes, between 18 and 65 years of age, who frequented public or private pharmacies for the purchase of medication. Data obtained by means of structured interviews revealed that 68.4% of those interviewed worked in rural activities, and 74.8% of these were members of families working in agriculture with contact with pesticides. The average age was 51+16.5 years of age for the interviewees with contact with pesticides and 50+17.9 years for those without contact. The sample was composed of 36.2% of men, and 57.7% of the individuals had more than four years of education. Direct or indirect contact with pesticides was associated with the report of several diseases, with neurological and oral diseases being the most prevalent. There was a link with painful conditions and individuals with contact with pesticides reported twice as many diseases. The data corroborate the literature and draw attention to the need for promoting measures to protect the health of the rural population.

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15.

Avaliação do impacto da exposição a agrotóxicos sobre a saúde de população rural: Vale do Taquari (RS, Brasil)
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Ciência & Saúde Coletiva

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aug 2011, Volume 16 N. 8 Pages 3519 - 3528

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

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