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au:Ferreira, Daniela C.

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[SciELO Preprints] - Guidelines on the Diagnosis and Treatment of Hypertrophic Cardiomyopathy – 2024
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Fernandes, Fabio Simões, Marcus V. Correia, Edileide de Barros Marcondes-Braga, Fabiana G. Coelho-Filho, Otavio Rizzi Mesquita, Cláudio Tinoco Mathias-Junior, Wilson Rochitte, Carlos Eduardo Ramires, Felix José Alvarez Alves, Silvia Marinho Martins Montera, Marcelo Westerlund Lopes, Renato Delascio Oliveira-Junior, Mucio Tavares Scolari, Fernando L. Avila, Walkiria Samuel Canesin, Manoel Fernandes Bacal, Fernando Bocchi, Edimar Alcides Moura, Lídia Ana Zytynski Saad, Eduardo Benchimol Scanavacca, Mauricio I. Valdigem, Bruno Pereira Cano , Manuel Nicolas Abizaid , Alexandre Ribeiro, Henrique Barbosa Lemos-Neto, Pedro Alves Ribeiro, Gustavo Calado de Aguiar Jatene, Fabio Biscegli Dias, Ricardo Ribeiro Beck-da-Silva, Luis Rohde, Luis Eduardo P. Bittencourt, Marcelo Imbroinise Pereira, Alexandre Krieger, José Eduardo Villacorta, Humberto Martins, Wolney de Andrade Figueiredo-Neto, José Albuquerque de Cardoso , Juliano Novaes Pastore, Carlos Alberto Jatene, Ieda Biscegli Tanaka, Ana Cristina Sayuri Hotta, Viviane Tiemi Romano, Minna Moreira Dias Albuquerque, Denilson Campos de Mourilhe-Rocha, Ricardo Hajjar, Ludhmila Abrahão Brito, Fabio Sandoli de Caramelli , Bruno Calderaro, Daniela Farsky, Pedro Silvio Colafranceschi , Alexandre Siciliano Pinto, Ibraim Masciarelli Vieira , Marcelo Luiz Campos Danzmann, Luiz Claudio Barberato , Silvio Henrique Mady, Charles Martinelli-Filho, Martino Torbey , Ana Flavia Malheiros Schwartzmann, Pedro Vellosa Macedo, Ariane Vieira Scarlatelli Ferreira , Silvia Moreira Ayub Schmidt, Andre Melo , Marcelo Dantas Tavares de Lima-Filho, Moysés Oliveira Sposito, Andrei C. Brito, Flavio de Souza Biolo, Andreia Madrini-Junior, Vagner Rizk, Stéphanie Itala Mesquita, Evandro Tinoco

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Publication date: 2024-04-08

Abstract: Pt Es En

A cardiomiopatia hipertrófica (CMH) é uma forma de doença do músculo cardíaco de causa genética, caracterizada pela hipertrofia das paredes ventriculares. O diagnóstico requer detecção por métodos de imagem (Ecocardiograma ou Ressonância Magnética Cardíaca) de qualquer segmento da parede do ventrículo esquerdo com espessura > 15 mm, sem outra causa provável. A análise genética permite identificar mutações de genes codificantes de diferentes estruturas do sarcômero responsáveis pelo desenvolvimento da CMH em cerca de 60% dos casos, permitindo o rastreio de familiares e aconselhamento genético, como parte importante do manejo dos pacientes e familiares. Vários conceitos sobre a CMH foram recentemente revistos, incluindo sua prevalência de 1 em 250 indivíduos, não sendo, portanto, uma doença rara, mas subdiagnosticada. A vasta maioria dos pacientes é assintomática. Naqueles sintomáticos, a obstrução do trato de saída do ventrículo esquerdo (OTSVE) é o principal distúrbio responsável pelos sintomas, devendo-se investigar a sua presença em todos os casos. Naqueles em que o ecocardiograma em repouso ou com Manobra de Valsalva não detecta gradiente intraventricular significativo (> 30 mmHg), devem ser submetidos à ecocardiografia com esforço físico para detecção da OTSVE.   Pacientes com sintomas limitantes e grave OTSVE, refratários ao uso de betabloqueadores e verapamil, devem receber terapias de redução septal ou uso de novas drogas inibidoras da miosina cardíaca. Por fim, os pacientes adequadamente identificados com risco aumentado de morta súbita podem receber medida profilática com implante de cardiodesfibrilador implantável (CDI).

La miocardiopatía hipertrófica (MCH) es una forma de enfermedad cardíaca de origen genético, caracterizada por el engrosamiento de las paredes ventriculares. El diagnóstico requiere la detección mediante métodos de imagen (Ecocardiograma o Resonancia Magnética Cardíaca) que muestren algún segmento de la pared ventricular izquierda con un grosor > 15 mm, sin otra causa probable. El análisis genético permite identificar mutaciones en genes que codifican diferentes estructuras del sarcómero responsables del desarrollo de la MCH en aproximadamente el 60% de los casos, lo que permite el tamizaje de familiares y el asesoramiento genético, como parte importante del manejo de pacientes y familiares. Varios conceptos sobre la MCH han sido revisados recientemente, incluida su prevalencia de 1 entre 250 individuos, por lo tanto, no es una enfermedad rara, sino subdiagnosticada. La gran mayoría de los pacientes son asintomáticos. En los casos sintomáticos, la obstrucción del tracto de salida ventricular izquierdo (TSVI) es el trastorno principal responsable de los síntomas, y su presencia debe investigarse en todos los casos. En aquellos en los que el ecocardiograma en reposo o la maniobra de Valsalva no detecta un gradiente intraventricular significativo (> 30 mmHg), deben someterse a ecocardiografía de esfuerzo para detectar la obstrucción del TSVI. Los pacientes con síntomas limitantes y obstrucción grave del TSVI, refractarios al uso de betabloqueantes y verapamilo, deben recibir terapias de reducción septal o usar nuevos medicamentos inhibidores de la miosina cardíaca. Finalmente, los pacientes adecuadamente identificados con un riesgo aumentado de muerte súbita pueden recibir medidas profilácticas con el implante de un cardioversor-desfibrilador implantable (CDI).

Hypertrophic cardiomyopathy (HCM) is a form of genetically caused heart muscle disease, characterized by the thickening of the ventricular walls. Diagnosis requires detection through imaging methods (Echocardiogram or Cardiac Magnetic Resonance) showing any segment of the left ventricular wall with a thickness > 15 mm, without any other probable cause. Genetic analysis allows the identification of mutations in genes encoding different structures of the sarcomere responsible for the development of HCM in about 60% of cases, enabling screening of family members and genetic counseling, as an important part of patient and family management. Several concepts about HCM have recently been reviewed, including its prevalence of 1 in 250 individuals, hence not a rare but rather underdiagnosed disease. The vast majority of patients are asymptomatic. In symptomatic cases, obstruction of the left ventricular outflow tract (LVOT) is the primary disorder responsible for symptoms, and its presence should be investigated in all cases. In those where resting echocardiogram or Valsalva maneuver does not detect significant intraventricular gradient (> 30 mmHg), they should undergo stress echocardiography to detect LVOT obstruction. Patients with limiting symptoms and severe LVOT obstruction, refractory to beta-blockers and verapamil, should receive septal reduction therapies or use new drugs inhibiting cardiac myosin. Finally, appropriately identified patients at increased risk of sudden death may receive prophylactic measure with implantable cardioverter-defibrillator (ICD) implantation.

https://doi.org/10.1590/SciELOPreprints.8394

Growth phenotypes of very low birth weight infants for prediction of neonatal outcomes from a Brazilian cohort: comparison with INTERGROWTH
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Cardoso, Viviane Cunha

; Grandi, Carlos

; Silveira, Rita C.

; Duarte, José Luiz Bandeira

; Viana, Maria Cândida Ferrarez Bouzada

; Ferreira, Daniela Marques de Lima Mota

; Alves Junior, José Mariano Sales

; Embrizi, Laís Furlan

; Gimenes, Carolina Boschi

; Mello e Silva, Nathalia Moura de

; Melo, Fernanda Pegoraro de Godoi

; Venzon, Paulyne Stadler

; Gomez, Dafne Barcala

; Vale, Marynéa Silva do

; Bentlin, Maria Regina

; Barros, Marina Carvalho de Moraes

; Bigélli, Laura Emilia Monteiro

; Diniz, Edna Maria de Albuquerque

; Luz, Jorge Hecker

; Marba, Sérgio Tadeu Martins

; Almeida, João Henrique Carvalho Leme de

; Aragon, Davi Casale

; Carmona, Fabio

Jornal de Pediatria

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jan 2023, Volume 99 N. 1 Pages 86 - 93

Abstract: En | Text: En | PDF: En

Abstract Objective: To assess the predictive value of selected growth phenotypes for neonatal morbidity and mortality in preterm infants < 30 weeks and to compare them with INTERGROWTH-21st (IG21). Methods: Retrospective analysis of data from the Brazilian Neonatal Research Network (BNRN) database for very low birth weight (VLBW) at 20 public tertiary-care university hospitals. Outcome: the composite neonatal morbidity and mortality (CNMM) consisted of in-hospital death, oxygen use at 36 weeks, intraventricular hemorrhage grade 3 or 4, and Bell stage 2 or 3 necrotizing enterocolitis. Selected growth phenotypes: small-for-gestational-age (SGA) defined as being < 3rd (SGA3) or 10th (SGA10) percentiles of BW, and large-for-gestational-age (LGA) as being > 97th percentile of BW. Stunting as being < 3rd percentile of the length and wasting as being < 3rd percentile of BMI. Single and multiple log-binomial regression models were fitted to estimate the relative risks of CNMM, comparing them to IG21. Results: 4,072 infants were included. The adjusted relative risks of CNMM associated with selected growth phenotypes were (BNRN/IG21): 1.45 (0.92–2.31)/1.60 (1.27–2.02) for SGA; 0.90 (0.55–1.47)/1.05 (0.55–1.99) for LGA; 1.65 (1.08–2.51)/1.58 (1.28–1.96) for stunting; and 1.48 (1.02–2.17) for wasting. Agreement between the two references was variable. The growth phenotypes had good specificity (>95%) and positive predictive value (70-90%), with poor sensitivity and low negative predictive value. Conclusion: The BNRN phenotypes at birth differed markedly from the IG21 standard and showed poor accuracy in predicting adverse neonatal outcomes.

https://doi.org/10.1016/j.jped.2022.07.007

Antifungal activity of liriodenine on clinical strains of Cryptococcus neoformans and Cryptococcus gattii species complexes
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Levorato-Vinche, Adriele Dandara

; Melhem, Marcia de Souza Carvalho

; Bonfietti, Lucas Xavier

; de-la-Cruz-Chacón, Iván

; Boaro, Carmen Sílvia Fernandes

; Fabro, Alexandre Todorovic

; Ferreira, Gisela

; Silva, Julhiany de Fátima da

; Santos, Daniela Carvalho dos

; Pereira, Beatriz Aparecida Soares

; Marçon, Camila

; Maza, Lariza

; Carvalho, Lídia Raquel de

; Mendes, Rinaldo Poncio

Journal of Venomous Animals and Toxins including Tropical Diseases

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2022, Volume 28 elocation e20220006

Abstract: En | Text: En | PDF: En

Abstract Background: Cryptoccocal meningitis continues to present high incidence among AIDS patients. The treatment of choice is the synergistic combination of flucytosine (5-FC) with amphotericin B deoxycholate (AmBd) or its lipid formulations. However, 5-FC is unavailable in many countries and AmB demands hospitalization. The combination of AmB with the fungistatic fluconazole (FLC) or the use of high FLC daily doses alone became the choice. Nonetheless, sterilization of cerebrospinal fluid is delayed with FLC monotherapy, mainly with high fungal burden. These findings suggest the search for new antifungal compounds, such as liriodenine. Methods: Liriodenine antifungal activity was evaluated by three procedures: determining the minimum inhibitory concentration (MIC) on 30 strains of the Cryptococcus neoformans (C. neoformans) complex and 30 of the Cryptococcus gattii (C. gattii) complex, using EUCAST methodology and amphotericin B deoxycholate as control; performing the time-kill methodology in two strains of the C. neoformans complex and one of the C. gattii complex; and injury to cryptococcal cells, evaluated by transmission electron microscopy (TEM). Liriodenine absorption and safety at 0.75 and 1.50 mg.kg-1 doses were evaluated in BALB/c mice. Results: Liriodenine MICs ranged from 3.9 to 62.5 μg.mL-1 for both species complexes, with no differences between them. Time-kill methodology confirmed its concentration-dependent fungicidal effect, killing all the strains below the limit of detection (33 CFU.mL-1) at the highest liriodenine concentration (32-fold MIC), with predominant activity during the first 48 hours. Liriodenine induced severe Cryptococcus alterations - cytoplasm with intense rarefaction and/or degradation, injury of organelles, and presence of vacuoles. Liriodenine was better absorbed at lower doses, with no histopathological alterations on the digestive tract. Conclusion: The fungicidal activity confirmed by time-kill methodology, the intense Cryptococcus injury observed by TEM, the absorption after gavage administration, and the safety at the tested doses indicate that the liriodenine molecule is a promising drug lead for development of anticryptococcal agents.

https://doi.org/10.1590/1678-9199-jvatitd-2022-0006

Análisis granulométrico de sedimentos y dinámica fluvial en la cuenca del río Lorohuasi (Cafayate, Salta)
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QUINTERO, Daniela I.

; AZAREVICH, Vanina LÓPEZ de

; FERREIRA, Silvia E.

; ROVERE, Adriana E.

; ESPINOZA, Patricia C.

; SULBELZA, Carolina R.

Serie correlación geológica

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jun 2021, Volume 37 N. 1 Pages 19 - 48

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

Abstract River processes have the ability to modify all terrestrial systems. The release of components, their transport and deposition as sediments by water have important environmental consequences, many of which can be deteriorating or irreversible. Arid regions are susceptible to water erosion, since the mere existence of water flow is exceptional and the common situation is its extreme speed, which is combined with the spatio-temporal variability of sediment transport. In this context, the objective was to analyze the dynamics of sediment transport in the Lorohuasi river basin, Cafayate, Salta, in the middle sections of the Alisal and Colorado tributaries, throughout the Lorohuasi river and the river mouth in the Santa María river, between the years 2016 and 2020. In 30 plots of 1 m2 located in 14 study sites, 30 samples of medium and fine sediments were collected in the active channel of the rivers. At each site, the width and slope of the channel was measured, as well as the flow, with the granulometric data of the medium sediments, were constructed accumulated frequency graphs and tables of statistical parameters (mean, median, mode, standard deviation, asymmetry and kurtosis), in order to characterize and analyze the distribution of the granulometric fractions along the river courses, evaluate the sedimentation dynamics and characterize the transport agent. The results show that in general lines, the mean granulometry of all the analyzed material transported in the Lorohuasi river basin is mean sand (phi 1.15), with mean-median-mode in the same fraction, the distribution is mesokurtic, symmetric and the material is poorly selected. The sediment is transported majorly by saltation in the Colorado and Alisal rivers, and by saltation and/or suspensión in the Lorohuasi river. It is concluded that the physical characteristics of the basin and anthropic activities influence the granulometry of the analyzed sediments, especially in the lower basin, and that rehabilitation techniques in affected riverbank areas could restore their functionality and protect the river system.

Resumen Los procesos fluviales tienen la capacidad de modificar todos los sistemas terrestres. La libe ración de componentes, su transporte y depositación como sedimentos por el agua, tienen consecuencias ambientales importantes, muchas de las cuales pueden ser deteriorantes o irreversibles. Las regiones áridas son susceptibles a la erosión hídrica, ya que la sola existencia de flujo ácueo es excepcional y la situación común es su extrema velocidad, que se conjuga con la variabilidad espacio-temporal del transporte de sedi mentos. En este contexto, el objetivo fue analizar la dinámica en el transporte de sedimentos en la cuenca del río Lorohuasi, Cafayate, Salta, en los tramos medio de los tributarios Alisal y Colorado, en todo el río Lorohuasi y el sector de desembocadura con el río Santa María, entre los años 2016 y 2020. En 30 parcelas de 1 m2 ubicadas en 14 sitios de estudios, se recolectaron 30 muestras de sedimentos medianos y finos en el cauce activo de los ríos. En cada sitio se midió el ancho y pendiente del cauce, como así también el caudal; con los datos granulométricos de los sedimentos medianos se construyeron gráficos de frecuencia acumu lada y tablas de parámetros estadísticos (media, mediana, moda, desviación estándar, asimetría y curtosis), a fin de caracterizar y analizar la distribución de las fracciones granulométricas a lo largo de los cursos fluviales, evaluar la dinámica de sedimentación y caracterizar el agente de transporte. Los resultados ex ponen que en general, la granulometría media de todo el material analizado transportado en la cuenca del río Lorohuasi es arena media (phi 1,15), con media-mediana-moda en la misma fracción, la distribución es mesocúrtica, simétrica y el material es pobremente seleccionado. El sedimento se transporta mayormente por saltación en los ríos Colorado y Alisal, y por saltación y/o suspensión en el río Lorohuasi. Se concluye que las características físicas de la cuenca y las actividades antrópicas influyen en la granulometría de los sedimentos analizados, especialmente en la cuenca baja, y que técnicas de rehabilitación en las riberas afectadas podrían devolver la funcionalidad de las mismas y proteger el sistema fluvial.

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Association between circulating exhausted CD4+ T cells with poor meningococcal C conjugate vaccine antibody response in HIV-infected children and adolescents
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Silva, Giselle P.

; Pereira-Manfro, Wania F.

; Costa, Priscilla R.

; Costa, Dayane A.

; Ferreira, Bianca

; Barreto, Daniela M.

; Frota, Ana Cristina C.

; Hofer, Cristina B.

; Figueredo, Carlos M.

; Coelho, Barbara

; Kallas, Esper G.

; Milagres, Lucimar G.

Clinics

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2021, Volume 76 elocation e2902

Abstract: En | Text: En | PDF: En

OBJECTIVES: To investigate the expression levels of surface markers of activation (CD38 and HLA-DR), inhibition (PD-1, TIGIT and CD57) and co-stimulation (CD28 and CD127) on CD4+ T cells of children/adolescents with vertical HIV infection (HI patients) and HIV-uninfected (HU) controls vaccinated with the meningococcal C conjugate vaccine (MCC). METHODS: HI patients (n=12), aged 8-17 years, were immunized with two MCC injections, while HU controls (n=9), aged 5.3-10.7 years, received a single MCC dose (as per national recommendation at the time of this study, a single MCC vaccine dose should be given for healthy children and youth aged 1-18 years). The HI patients were categorized according to the combined antiretroviral therapy (cART) treatment. Blood samples were obtained before vaccination, after priming, and after the administration of a booster dose of vaccine to determine the serum bactericidal antibody (SBA) titers and the expression levels of surface markers on CD4+ T cells by flow cytometry. The levels of serum cytokines, IL-4 and CXCL-13 were also measured using Luminex kits. RESULTS: The co-expression of the TIGIT-HLA-DR-CD38 molecules increased in the CD4+ T cells of HI patients/no-cART who also showed a lower frequency of CD127+CD28+ CD4+ T cells than HI patients/cART and HU group subjects. There were significant negative correlations between the frequency of exhausted CD4+ T cells and the SBA response. IL-4 levels were higher in HI patients/cART and positively correlated with SBA titers but negatively associated with the expression of exhaustion markers. Moreover, the CXCL-13 levels were positively correlated with the exhausted CD4+ T cells. CONCLUSION: The results of our study suggest that the co-expression of exhaustion markers and/or loss of co-stimulatory molecules influence the SBA response in HI patients.

https://doi.org/10.6061/clinics/2021/e2902 127 downloads

Antifungal activity of liriodenine on agents of systemic mycoses, with emphasis on the genus Paracoccidioides
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Vinche, Adriele Dandara Levorato

; de- la-Cruz-Chacón, Iván

; González-Esquinca, Alma Rosa

; Silva, Julhiany de Fátima da

; Ferreira, Gisela

; Santos, Daniela Carvalho dos

; Garces, Hans Garcia

; Oliveira, Daniela Vanessa Moris de

; Marçon, Camila

; Cavalcante, Ricardo de Souza

; Mendes, Rinaldo Poncio

Journal of Venomous Animals and Toxins including Tropical Diseases

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2020, Volume 26 elocation e20200023

Abstract: En | Text: En | PDF: En

Abstract Background: Endemic systemic mycoses remain a health challenge, since these opportunistic diseases are increasingly infecting immunosuppressed patients. The simultaneous use of antifungal compounds and other drugs to treat infectious or non-infectious diseases has led to several interactions and undesirable effects. Thus, new antifungal compounds should be investigated. The present study aimed to evaluate the activity of liriodenine extracted from Annona macroprophyllata on agents of systemic mycoses, with emphasis on the genus Paracoccidioides. Methods: The minimum inhibitory concentration (MIC) and minimum fungicide concentration (MFC) were determined by the microdilution method. The cellular alterations caused by liriodenine on a standard P. brasiliensis (Pb18) strain were evaluated by transmission and scanning electron microscopy. Results: Liriodenine was effective only in 3 of the 8 strains of the genus Paracoccidioides and in the Histoplasma capsulatum strain, in a very low concentration (MIC of 1.95 μg.mL-1); on yeasts of Candida spp. (MIC of 125 to 250 μg.mL-1), including C. krusei (250 μg.mL-1), which has intrinsic resistance to fluconazole; and in Cryptococcus neoformans and Cryptococcus gattii (MIC of 62.5 μg.mL-1). However, liriodenine was not effective against Aspergillus fumigatus at the studied concentrations. Liriodenine exhibited fungicidal activity against all standard strains and clinical isolates that showed to be susceptible by in vitro tests. Electron microscopy revealed cytoplasmic alterations and damage to the cell wall of P. brasiliensis (Pb18). Conclusion: Our results indicate that liriodenine is a promising fungicidal compound that should undergo further investigation with some chemical modifications.

https://doi.org/10.1590/1678-9199-jvatitd-2020-0023 663 downloads

Comparative cytogenetics of Astyanax (Teleostei: Characidae) from the upper Paraguay basin
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Teixeira, Thais K. S. S.

; Venere, Paulo C.

; Ferreira, Daniela C.

; Mariotto, Sandra

; Castro, Jonathan P.

; Artoni, Roberto F.

; Centofante, Liano

Neotropical Ichthyology

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2018, Volume 16 N. 1 elocation e170092

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Astyanax é um dos táxons mais representados e diversos na região Neotropical. Com o intuito de aumentar as informações citogenéticas para Astyanax e apresentar dados que possam subsidiar estudos taxonômicos futuros, este trabalho traz uma análise citogenética de três espécies de Astyanax: duas espécies consideradas crípticas, aqui reportadas em sintopia (A. abramis e A. lacustris) e a primeira descrição cariotípica de A. pirapuan. As análises citogenéticas revelaram 2n=50 cromossomos para as três espécies, com diferença na morfologia cariotípica de cada uma. Foram observados apenas dois sítios de rDNA 18S em A. abramis e A. lacustris e até 13 para A. pirapuan. O mapeamento físico do rDNA 5S se mostrou como um marcador efetivo para a caracterização das espécies de Astyanax abordadas neste estudo.

ABSTRACT Astyanax is one of the most abundant and diverse taxa of fishes in the Neotropical region. In order to increase the amount of cytogenetic information for Astyanax as well as to exhibit data to subsidize future taxonomic studies, this work analyzed three species of Astyanax: two species are cryptic, and are here reported to live in syntopy (A. abramis and A. lacustris); the first karyotype description for A. pirapuan is also presented. Cytogenetic analyzes reveal a diploid number of 2n=50 chromosomes for three species, yet with differences in their karyotype morphology. The physical mapping of 18S rDNA showed up to thirteen sites in A. pirapuan and two in A. abramis and A. lacustris. The physical mapping of 5S rDNA has proven to be an effective marker for the characterization of species of Astyanax studied in this work.

https://doi.org/10.1590/1982-0224-20170092 1331 downloads

Rhizophagus Clarus and Phosphorus in Crotalaria juncea: Growth, Glomalin Content and Acid Phosphatase Activity in a Copper-Contaminated Soil
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Ferreira, Paulo Ademar Avelar

; Ceretta, Carlos Alberto

; Tiecher, Tales

; Facco, Daniela Basso

; Garlet, Luana Paula

; Soares, Cláudio Roberto Fonsêca Sousa

; Soriani, Hilda Hildebrand

; Nicoloso, Fernando Teixeira

; Giachini, Admir José

; Brunetto, Gustavo

; Cornejo, Pablo

Revista Brasileira de Ciência do Solo

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2018, Volume 42 elocation e0170245

Abstract: En | Text: En | PDF: En

ABSTRACT Crotalaria juncea is used as plant cover in grape vineyards in Brazil, which usually present soils with high copper (Cu) levels due to the application of Cu-based phyto-sanitary products. Under this condition an increase growth and cover of C. juncea is needed to improve the phytoremediation processes in those soils. Some alternatives to achieve this condition is the inoculation with arbuscular mycorrhizal fungi (AMF), which has demonstrated an important increase of plant growth in Cu-contaminated soils at different soil P levels. The aims of this study were to evaluate the effect of AMF inoculation in soils with high Cu contents on the growth of C. juncea, the acid phosphatase (APase) enzyme activity in plants and soil, and the presence of glomalin under different P supply conditions, as a basis to identify if there is a synergistic interaction between AMF inoculation and P supply on soils with high Cu levels. The experiment was carried under greenhouse conditions in a factorial 3 × 2 design (natural P content, addition of 40 and 100 mg kg-1 P, with and without the inoculation of the AMF Rhizophagus clarus with three replicates) in a soil with high Cu content (60 mg kg-1). The addition of 40 and 100 mg kg-1 P favored plant growth both in the presence and in the absence of AMF. However, when plants were grown in soil with a natural P level, the inoculation with AMF increased by 116 % the shoot biomass, compared to the non-inoculated treatment. Our results showed that the combination of P supply and R. clarus inoculation could be an adequate strategy to reduce Cu phytotoxicity in C. juncea, as it increases plant biomass and modify the APase enzyme activity in the soil and plant. Additionally, glomalin produced by the AMF and accumulated in the soil can decrease the availability of Cu to the plants by means of sequestration beyond the root surface, with a consequent plant protective effect.

https://doi.org/10.1590/18069657rbcs20170245 990 downloads

Autoimmune hepatitis in 847 childhoodonset systemic lupus erythematosus population: a multicentric cohort study
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Balbi, Verena A.

; Montenegro, Bárbara

; Pitta, Ana C.

; Schmidt, Ana R.

; Farhat, Sylvia C.

; Coelho, Laila P.

; Ferreira, Juliana C. O.

; Pereira, Rosa M. R.

; Terreri, Maria T.

; Saad-Magalhães, Claudia

; Aikawa, Nadia E.

; Sakamoto, Ana P.

; Kozu, Kátia

; Campos, Lucia M.

; Sallum, Adriana M.

; Ferriani, Virginia P.

; Piotto, Daniela P.

; Bonfá, Eloisa

; Silva, Clovis A.

Advances in Rheumatology

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2018, Volume 58 elocation 43

Abstract: En | Text: En | PDF: En

Abstract Objective: To evaluate autoimmune hepatitis (AIH) in a multicenter cohort of childhood-onset systemic lupus erythematosus (cSLE) patients. Methods: This retrospective multicenter study included 847 patients with cSLE, performed in 10 Pediatric Rheumatology services of São Paulo state, Brazil. AIH was defined according to the International Autoimmune Hepatitis Group criteria (IAHGC). The statistical analysis was performed using the Bonferroni's correction (p < 0.0033). Results: AIH in cSLE patients confirmed by biopsy was observed in 7/847 (0.8%) and all were diagnosed during adolescence. The majority occurred before or at cSLE diagnosis [5/7 (71%)]. Antinuclear antibodies were a universal finding, 43% had concomitantly anti-smooth muscle antibodies and all were seronegative for anti-liver kidney microsomal antibodies. All patients with follow-up ≥18 months (4/7) had complete response to therapy according to IAHGC. None had severe hepatic manifestations such as hepatic failure, portal hypertension and cirrhosis at presentation or follow-up. Further comparison of 7 cSLE patients with AIH and 28 without this complication with same disease duration [0 (0–8.5) vs. 0.12 (0–8.5) years, p = 0.06] revealed that the frequency of hepatomegaly was significantly higher in cSLE patients in the former group (71% vs. 11%, p = 0.003) with a similar median SLEDAI-2 K score [6 (0–26) vs. 7 (0–41), p = 0.755]. No differences were evidenced regarding constitutional involvement, splenomegaly, serositis, musculoskeletal, neuropsychiatric and renal involvements, and treatments in cSLE patients with and without AIH (p > 0.0033). Conclusions: Overlap of AIH and cSLE was rarely observed in this large multicenter study and hepatomegaly was the distinctive clinical feature of these patients. AIH occurred during adolescence, mainly at the first years of lupus and it was associated with mild liver manifestations.

https://doi.org/10.1186/s42358-018-0043-7 473 downloads

10.

Financeirização e dinâmica do capitalismo contemporâneo. Notas de apresentação
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Prates, Daniela M.

; Oliveira, Giuliano C.

; Ferreira, Adriana N.

; Baltar, Carolina T.

Economia e Sociedade

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dec 2017, Volume 26 N. spe Pages i - vi

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

https://doi.org/10.1590/1982-3533.2017v26n4art01 2249 downloads

11.

3rd Guideline for Perioperative Cardiovascular Evaluation of the Brazilian Society of Cardiology
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Gualandro, Danielle Menosi

; Yu, Pai Ching

; Caramelli, Bruno

; Marques, André Coelho

; Calderaro, Daniela

; Fornari, Luciana Savoy

; Pinho, Claudio

; Feitosa, Alina Coutinho Rodrigues

; Polanczyk, Carisi Anne

; Rochitte, Carlos Eduardo

; Jardim, Carlos

; Vieira, Carolina L. Z.

; Nakamura, Debora Y. M.

; Iezzi, Denise

; Schreen, Dirk

; Adam, Eduardo Leal

; D’Amico, Elbio Antonio

; Lima, Emerson Q. de

; Burdmann, Emmanuel de Almeida

; Mateo, Enrique Indalecio Pachón

; Marcondes-Braga, Fabiana Goulart

; Machado, Fabio S.

; Paula, Flavio J. de

; Carmo, Gabriel Assis Lopes do

; Feitosa-Filho, Gilson Soares

; Prado, Gustavo Faibischew

; Lopes, Heno Ferreira

; Fernandes, João R. C.

; Lima, José J. G. de

; Sacilotto, Luciana

; Drager, Luciano Ferreira

; Vacanti, Luciano Janussi

; Rohde, Luis Eduardo Paim

; Prada, Luis F. L.

; Gowdak, Luis Henrique Wolff

; Vieira, Marcelo Luiz Campos

; Monachini, Maristela Camargo

; Macatrão-Costa, Milena Frota

; Paixão, Milena Ribeiro

; Oliveira Junior, Mucio Tavares de

; Cury, Patricia

; Villaça, Paula R.

; Farsky, Pedro Silvio

; Siciliano, Rinaldo F.

; Heinisch, Roberto Henrique

; Souza, Rogerio

; Gualandro, Sandra F.M.

; Accorsi, Tarso Augusto Duenhas

; Mathias Júnior, Wilson

Arquivos Brasileiros de Cardiologia

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sep 2017, Volume 109 N. 3 Pages 1 - 104

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

https://doi.org/10.5935/abc.20170140 100302 downloads

12.

Atualização da Diretriz Brasileira de Dislipidemias e Prevenção da Aterosclerose – 2017
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Faludi, André Arpad

; Izar, Maria Cristina de Oliveira

; Saraiva, José Francisco Kerr

; Chacra, Ana Paula Marte

; Bianco, Henrique Tria

; Afiune Neto, Abrahão

; Bertolami, Adriana

; Pereira, Alexandre C.

; Lottenberg, Ana Maria

; Sposito, Andrei C.

; Chagas, Antonio Carlos Palandri

; Casella Filho, Antonio

; Simão, Antônio Felipe

; Alencar Filho, Aristóteles Comte de

; Caramelli, Bruno

; Magalhães, Carlos Costa

; Negrão, Carlos Eduardo

; Ferreira, Carlos Eduardo dos Santos

; Scherr, Carlos

; Feio, Claudine Maria Alves

; Kovacs, Cristiane

; Araújo, Daniel Branco de

; Magnoni, Daniel

; Calderaro, Daniela

; Gualandro, Danielle Menosi

; Mello Junior, Edgard Pessoa de

; Alexandre, Elizabeth Regina Giunco

; Sato, Emília Inoue

; Moriguchi, Emilio Hideyuki

; Rached, Fabiana Hanna

; Santos, Fábio César dos

; Cesena, Fernando Henpin Yue

; Fonseca, Francisco Antonio Helfenstein

; Fonseca, Henrique Andrade Rodrigues da

; Xavier, Hermes Toros

; Mota, Isabela Cardoso Pimentel

; Giuliano, Isabela de Carlos Back

; Issa, Jaqueline Scholz

; Diament, Jayme

; Pesquero, João Bosco

; Santos, José Ernesto dos

; Faria Neto, José Rocha

; Melo Filho, José Xavier de

; Kato, Juliana Tieko

; Torres, Kerginaldo Paulo

; Bertolami, Marcelo Chiara

; Assad, Marcelo Heitor Vieira

; Miname, Márcio Hiroshi

; Scartezini, Marileia

; Forti, Neusa Assumpta

; Coelho, Otávio Rizzi

; Maranhão, Raul Cavalcante

; Santos Filho, Raul Dias dos

; Alves, Renato Jorge

; Cassani, Roberta Lara

; Betti, Roberto Tadeu Barcellos

; Carvalho, Tales de

; Martinez, Tânia Leme da Rocha

; Giraldez, Viviane Zorzanelli Rocha

; Salgado Filho, Wilson

Arquivos Brasileiros de Cardiologia

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aug 2017, Volume 109 N. 2 Pages 1 - 76

Abstract: Pt | Text: Pt | PDF: Pt

https://doi.org/10.5935/abc.20170121 199102 downloads

13.

Molecular and morphological approaches for species delimitation and hybridization investigations of two Cichla species
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Mourão, Andrea A. F.

; Freitas-Souza, Diogo

; Hashimoto, Diogo T.

; Ferreira, Daniela C.

; Prado, Fernanda D. do

; Silveira, Rosicleire V.

; Foresti, Fausto

; Porto-Foresti, Fábio

Iheringia. Série Zoologia

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2017, Volume 107 elocation e2017016

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO A hibridação é uma questão amplamente discutida em vários estudos com espécies de peixes. Para alguns autores, hibridações podem estar relacionadas à diversificação e especiação de muitos grupos, ou à extinção de populações ou espécies. Dificuldades para diferenciar espécies e híbridos podem ser um problema para aplicar corretamente o manejo de espécies selvagens, porque linhagens híbridas, especialmente as mais avançadas, podem assemelhar-se aos parentais. O gênero Cichla Bloch & Schneider, 1801 constitui um interessante modelo experimental, considerando que a hibridação e as incertezas taxonômicas dificultam a correta identificação. Considerando estes problemas, neste estudo foram desenvolvidas metodologias genéticas e aplicadas abordagens merísticas e morfométricas em amostras selvagens para identificar espécies e para testar uma possível hibridação entre Cichla kelberi Kullander & Ferreira, 2006 e Cichla piquiti Kullander & Ferreira, 2006. Para isto, C. kelberi, C. piquiti e indivíduos do híbrido em potencial ( carijó) foram coletados nos rios Paraná e Tietê (SP, Brasil). Para os métodos merístico e morfométrico, os indivíduos foram analisados, utilizando-se o software estatístico Pcord 5:31, enquanto que para os métodos moleculares, primers para PCR-multiplex foram desenhados e enzimas para PCR-RFLP foram selecionadas, sob nucleotídeos espécie-específicos. Todos os resultados indicaram que o carijó não é um híbrido interespecífico, porque apresentou padrão genético idêntico e morfologia próxima à C. piquiti. Assim, propomos que o carijó é um morfotipo de C. piquiti. Além disso, este estudo promove uma nova ferramenta molecular que poderá ser utilizada em futuras pesquisas, monitoramento e manejo do gênero Cichla.

ABSTRACT The hybridization is a widely-discussed issue in several studies with fish species. For some authors, hybridization may be related with diversification and speciation of several groups, or also with the extinction of populations or species. Difficulties to differentiate species and hybrids may be a problem to correctly apply a management of wild species, because hybrid lineages, especially the advanced ones, may resemble the parental species. The genus Cichla Bloch & Schneider, 1801 constitutes an interesting experimental model, considering that hybridization and taxonomic uncertainties hinder a correct identification. Considering these problems, in this study, we developed genetic methodologies and applied meristic and morphometric approaches in wild samples in order to identify species and for test a possible hybridization between Cichla kelberi Kullander & Ferreira, 2006 and Cichla piquiti Kullander & Ferreira, 2006. For this, C. kelberi, C. piquiti and potential hybrid ( carijó) individuals were collected in Paraná and Tietê rivers (SP, Brazil). For meristic and morphometric methods, the individuals were analyzed using the statistical software Pcord 5:31, while for molecular methods, primers for PCR-multiplex were designed and enzyme for PCR-RFLP were selected, under the species-specific nucleotide. All results indicated that the carijó is not an interspecific hybrid, because it presented identical genetic pattern and morphology closed to C. piquiti. Thus, we propose that carijó is a C. piquiti morphotype. In addition, this study promotes a new molecular tool that could be used in future research, monitoring and management programs of the genus Cichla.

https://doi.org/10.1590/1678-4766e2017016 1817 downloads

14.

UV-Assisted Digestion of Petrochemical Industry Effluents Prior to the Determination of Zn, Cd, Pb and Cu by Differential Pulse Anodic Stripping Voltammetry
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Domingos, Daniela

; Ferreira Neta, Maria de Lourdes S.

; Massa, Ana Rosa C. G.

; Reboucas, Marcio V.

; Teixeira, Leonardo S. G.

Journal of the Brazilian Chemical Society

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sep 2016, Volume 27 N. 9 Pages 1594 - 1601

Abstract: En | Text: En | PDF: En

A petrochemical effluent is usually a matrix of very high complexity and composition variability, requiring robust and suitable methods for routine analysis. In this paper, the feasibility of applying a voltammetric technique for the determination of metals species in the petrochemical industry effluent was demonstrated after UV-assisted digestion procedure. Voltammetric (electrolyte volume, deposit time, pulse time, pulse amplitude and scan rate) and digestion variables (hydrogen peroxide volume, nitric acid volume and digestion time) were studied using a 2-level factorial design. The developed voltammetric method using anodic stripping voltammetry (ASV) presented limits of quantification of 11, 5, 15 and 5 µg L−1 for Zn, Cd, Pb and Cu, respectively, and was effective to analyze petrochemical effluents after UV-digestion.

https://doi.org/10.5935/0103-5053.20160039 681 downloads

15.

A protein expression system for tandem affinity purification in Xanthomonas citri subsp. citri
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Dantas, Giordanni C.

; Martins, Paula M.M.

; Martins, Daniela A.B.

; Gomes, Eleni

; Ferreira, Henrique

Brazilian Journal of Microbiology

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jun 2016, Volume 47 N. 2 Pages 518 - 526

Abstract: En | Text: En | PDF: En

Abstract Citrus canker, caused by the Gram-negative bacterium Xanthomonas citri subsp. citri (Xac), is one of the most devastating diseases to affect citrus crops. There is no treatment for citrus canker; effective control against the spread of Xac is usually achieved by the elimination of affected plants along with that of asymptomatic neighbors. An in depth understanding of the pathogen is the keystone for understanding of the disease; to this effect we are committed to the development of strategies to ease the study of Xac. Genome sequencing and annotation of Xac revealed that ∼37% of the genome is composed of hypothetical ORFs. To start a systematic characterization of novel factors encoded by Xac, we constructed integrative-vectors for protein expression specific to this bacterium. The vectors allow for the production of TAP-tagged proteins in Xac under the regulation of the xylose promoter. In this study, we show that a TAP-expression vector, integrated into the amy locus of Xac, does not compromise its virulence. Furthermore, our results also demonstrate that the polypeptide TAP can be overproduced in Xac and purified from the soluble phase of cell extracts. Our results substantiate the use of our vectors for protein expression in Xac thus contributing a novel tool for the characterization of proteins and protein complexes generated by this bacterium in vivo.

https://doi.org/10.1016/j.bjm.2016.01.026 1365 downloads

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