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ABSTRACT The expression ‘you need to know to conserve’ is a well-known cliche among biologists. Documenting the richness of a group of organisms is the first step towards understanding biodiversity and preparing efficient conservation plans. In this context, many efforts have been made to quantify the number of species on Earth and estimate the number of species still unknown to science. A few countries have complete and integrated databases estimating the approximate number of species recorded for their territory, particularly in the Global South. In Brazil, a country of continental dimensions, revealing the richness of the second most diverse clade of invertebrates (=Mollusca) has been a goal of taxonomists. Recently, in an unprecedented, collective, and integrated effort among Brazilian malacologists, it was possible to estimate how many valid species of molluscs are there in Brazil. In this effort, more than 30 mollusc experts joined together to update the Taxonomic Catalogue of the Brazilian Fauna (TCBF), a governmental website that allows a quick and real-time updating of all Metazoan. So far, more than 5,000 updates have been made in TCBF, indicating the presence of 3,552 valid species of molluscs in Brazil, distributed among the main clades as follows: Caudofoveata (10 spp.), Solenogastres (6 spp.), Polyplacophora (35 spp.), Scaphopoda (43 spp.), Cephalopoda (92 spp.), Bivalvia (629 spp.) and Gastropoda (2,737 spp.). The present study, in addition to demonstrating for the first time the richness of Brazilian molluscs, also presents the state of the art of this important phylum of invertebrates highlighting its most representative and neglected groups.

https://doi.org/10.1590/s1984-4689.v40.e23026

CYP450 Metabolism of a Semisynthetic Naphthoquinone, an Anticancer Drug Candidate, by Human Liver Microsomes
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Costa, Edna M. A.

; Carrão, Daniel B.

; Bucci, Jade L. M.

; Oliveira, Anderson R. M.

; Machado, Tallita M.

; Ferreira, Vitor F.

; Lima, Émerson S.

; Vasconcellos, Marne C.

; Magalhães, Igor R. S.

Journal of the Brazilian Chemical Society

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oct 2022, Volume 33 N. 10 Pages 1145 - 1153

Abstract: En | Text: En | PDF: En

CNFD (6b,7-dihydro-5H-cyclopenta[b]naphtho[2,1-d]furan-5,6(9aH)-dione) is a semisynthetic naphthoquinone derived from lawsone that has cytotoxic action in different tumor lines and anticancer activity in vivo. Therefore, this molecule is a relevant candidate for drug development, but there is still no information on its human metabolism and systemic elimination. This study aimed to investigate the in vitro metabolism of this naphthoquinone by human liver microsomes. Initially, in order to determine the in vitro enzymatic kinetic parameters, a high performance liquid chromatography (HPLC) method to quantify the CNFD was developed and validated. In addition, the enzymatic kinetic data, the predicted pharmacokinetic in vivo parameters and the phenotyping study were presented. The main metabolism sites and metabolites have been suggested in silico. The developed HPLC method was linear, reproducible, selective, accurate, and stable. The enzymatic kinetic parameters revealed a sigmoidal profile. In vitro to in vivo extrapolation hepatic metabolic clearance was 10.39 mL min-1 kg-1 protein and the liver extraction rate was 51%. The clearance in vivo associated with a hepatic extraction ratio indicates that the hepatic metabolism is the main route of elimination. Although all cytochrome P450 enzymes evaluated metabolized CNFD, CYP2C9 and CYP3A4 showed higher metabolic capacity. For the first time, metabolism studies of CNFD were demonstrated.

https://doi.org/10.21577/0103-5053.20220034

The Effect of Turbinate Injection of Botulinum Toxin A on the Symptoms of Idiopathic Rhinitis
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Carvalho, Thiago

; Salgado, Daniel Calduro

; Mion, Olavo de Godoy

; Mello Junior, João Ferreira de

; Voegels, Richard Louis

International Archives of Otorhinolaryngology

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jun 2022, Volume 26 N. 2 Pages e191 - e198

Abstract: En | Text: En | PDF: En

Abstract Introduction Idiopathic rhinitis is a nonallergic and noninfectious rhinitis characterized mainly by nasal obstruction and rhinorrhea, resulting from an autonomic imbalance. Botulinum toxin type A (BTX-A) demonstrated its action in reducing rhinorrhea and nasal obstruction when injected into the nasal turbinates or septum. Objective To analyze the effects of intranasal BTX-A injection to control the symptoms of idiopathic rhinitis and its possible adverse effects. Method Patients with idiopathic rhinitis were divided into two groups. Group A had 15 participants (8 female and 6 male), of ages from 47 to 84 years (mean 66.57 years), and these received 60 U of Dysport (Ipsen Ltd, Maidenhead, Berkshire, UK) in each inferior nasal turbinate; group B had 12 participants (1 male and 11 female), of ages from 50 to 76 years (mean 60 years), and they received 1 ml of 0.9% saline. The individuals were reevaluated in the 1st, 2nd, 4th, 8th, and 12th weeks after injection by a questionnaire, accompanied by nasal inspiratory peak flow and acoustic rhinometry. Results Group A showed significant improvement, mainly regarding the symptoms of sneezing/itching and nasal obstruction, over time and when compared to group B. Acoustic rhinometry confirmed the improvement in nasal obstruction. There was no relationship between the nasal peak flow data and the nasal obstruction score. No major adverse effects have been reported. Conclusion The injection of botulinum toxin in the inferior nasal turbinates of patients with idiopathic rhinitis reduces the symptoms of sneezing, itching, nasal obstruction, and runny nose without significant adverse effects, suggesting that it is an option in the treatment of these patients.

https://doi.org/10.1055/s-0041-1730307

Evaluation of cerebral hemodynamics by transcranial Doppler ultrasonography and its correlation with intracranial pressure in an animal model of intracranial hypertension
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SOARES, Matheus Schmidt

; ANDRADE, Almir Ferreira de

; BRASIL, Sérgio

; DE-LIMA-OLIVEIRA, Marcelo

; BELON, Alessandro Rodrigo

; BOR-SENG-SHU, Edson

; NOGUEIRA, Ricardo de Carvalho

; GODOY, Daniel Agustin

; PAIVA, Wellingson Silva

Arquivos de Neuro-Psiquiatria

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apr 2022, Volume 80 N. 4 Pages 344 - 352

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Antecedentes: O Doppler transcraniano (DTC) é uma técnica não invasiva para a avaliação da hemodinâmica cerebral, porém existem controvérsias na literatura sobre sua aplicabilidade preditiva em situações de elevada pressão intracraniana (PIC). Objetivo: Investigar o fluxo sanguíneo cerebral pelo DTC e correlacioná-lo com as variações da PIC na fase aguda da hipertensão intracraniana em modelo animal. Métodos: Dois grupos de animais (suínos) foram submetidos a hipertensão intracraniana secundária à indução de diferentes volumes de hematoma, por meio da insuflação de balão intracraniano controlado com 4 e 7 mL de solução salina fisiológica (grupos A e B, respectivamente). Em seguida, administrou-se infusão venosa de solução salina hipertônica (SSH 3%). Foram coletados os valores dos parâmetros de PIC e DTC (velocidade sistólica [FVs], diastólica [FVd] e média [FVm] do fluxo sanguíneo cerebral), bem como o índice de pulsatilidade (IP). Comparações entre os parâmetros do DTC e o monitoramento da PIC foram realizadas. Resultados: Vinte porcos foram estudados, dez no grupo A e dez no grupo B. Correlação significativa entre IP e PIC foi obtida, principalmente logo após a elevação abrupta da PIC. Não houve correlação entre PIC e FVs, FVd ou FVm separadamente. Também não houve alteração significativa na PIC após a infusão de SSH. Conclusões: Esses resultados demonstram o potencial do IP como um bom parâmetro para a avaliação de pacientes com suspeita de elevação da PIC.

ABSTRACT Background: Transcranial Doppler has been tested in the evaluation of cerebral hemodynamics as a non-invasive assessment of intracranial pressure (ICP), but there is controversy in the literature about its actual benefit and usefulness in this situation. Objective: To investigate cerebral blood flow assessed by Doppler technique and correlate with the variations of the ICP in the acute phase of intracranial hypertension in an animal model. Methods: An experimental animal model of intracranial hypertension was used. The experiment consisted of two groups of animals in which intracranial balloons were implanted and inflated with 4 mL (A) and 7 mL (B) for controlled simulation of different volumes of hematoma. The values of ICP and Doppler parameters (systolic [FVs], diastolic [FVd], and mean [FVm] cerebral blood flow velocities and pulsatility index [PI]) were collected during the entire procedure (before and during hematoma simulations and venous hypertonic saline infusion intervention). Comparisons between Doppler parameters and ICP monitoring were performed. Results: Twenty pigs were studied, 10 in group A and 10 in group B. A significant correlation between PI and ICP was obtained, especially shortly after abrupt elevation of ICP. There was no correlation between ICP and FVs, FVd or FVm separately. There was also no significant change in ICP after intravenous infusion of hypertonic saline solution. Conclusions: These results demonstrate the potential of PI as a parameter for the evaluation of patients with suspected ICP elevation.

https://doi.org/10.1590/0004-282x-anp-2020-0591

Tradução para o português An International Continence Society (ICS) report on the terminology for adult neurogenic lower urinary tract dysfunction (ANLUTD)
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Fernandes, Ailton

; Sacomani, Carlos Alberto Ricetto

; Averbeck, Márcio

; Prezotti, José Antônio

; Ferreira, Ruiter Silva

; Moser, Daniel

; Gajewski, Jerzy B.

einstein (São Paulo)

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2022, Volume 20 elocation eAE5680

Abstract: Pt | Text: Pt | PDF: Pt

RESUMO Introdução A terminologia para disfunção neurogênica do trato urinário inferior em adultos (DNTUIA) deve ser definida e organizada com base clínica em um relatório de consenso. Métodos Este relatório foi criado por um Grupo de Trabalho sob o endosso e diretrizes do Standardization Steering Committee (SSC) da International Continence Society (ICS), auxiliado em intervalos por julgadores externos. Todas as definições relevantes para DNTUIA foram atualizadas com base em pesquisas nos últimos 14 anos. Um extenso processo de 18 rodadas de revisão interna e externa foi realizado para examinar exaustivamente cada definição, com tomada de decisão pela opinião coletiva (consenso). Resultados O Relatório de Terminologia para a DNTUIA, englobando 97 definições (42 novas e oito modificadas), foi desenvolvido. Este relatório é clinicamente baseado nos diagnósticos definidos mais comuns. Clareza e facilidade de uso têm sido os principais objetivos para torná-lo interpretável por profissionais e pessoas em treinamento em todos os diferentes grupos envolvidos não só na disfunção do trato urinário inferior, mas também em muitas outras especialidades médicas. Conclusão Baseado no consenso, o Relatório de Terminologia para a DNTUIA foi produzido para auxiliar na pesquisa e na prática clínica.

https://doi.org/10.31744/einstein_journal/2022ae5680

Anti-Leishmania amazonensis activity of the marine sponge Dercitus (Stoeba) latex (Porifera) from São Pedro and São Paulo Archipelago, Pernambuco, Brazil
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BARRETO, ANNA L.S.

; ALONSO, ARIADNE N.

; MORAES, DANIEL C. DE

; CURVELO, JOSÉ A.R.

; MIRANDA, KILDARE

; PORTELA, MARISTELA B.

; FERREIRA-PEREIRA, ANTÔNIO

; SOUTO-PADRÓN, THAIS

; SOARES, ROSANGELA MARIA DE A.

Anais da Academia Brasileira de Ciências

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2022, Volume 94 N. 3 elocation e20211090

Abstract: En | Text: En | PDF: En

Abstract The search for new therapeutic strategies for leishmaniasis treatment is essential due to the side effects of available drugs and the increasing incidence of resistance to them. Marine sponges use chemical compounds as a defense mechanism, and several of them present interesting pharmacological properties. The aim of this study was to evaluate the in vitro activity of the aqueous extract of the marine sponge Dercitus (Stoeba) latex against Leishmania amazonensis. MIC and toxicity against mammal cells were evaluated through broth microdilution assays. Transmission electron microscopy analysis was performed to assess possible effects on L. amazonensis ultrastructure. Arginase and proteolytic activities were measured by spectrometric methodologies. The extract of Dercitus (Stoeba) latex displayed antileishmanial activity and moderate toxicity against peritonial macrophages. Ultrastructural changes were observed after the growth of L. amazonensis promastigotes in the presence of the extract at 150 µg.ml-1 (IC50), mainly on acidocalcysomes. The extract was able to inhibit the activity of arginase and serine proteases. This study shows that Dercitus (Stoeba) latex aqueous extract may be a novel potential source of protozoa protease inhibitors and drugs that are less toxic to be used in the treatment of L. amazonensis infections.

https://doi.org/10.1590/0001-3765202220211090

The Effect of EDTA Functionalization on Fe3O4 Thermal Behavior
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Fumis, Daniel B.

; Silveira, Maria L.D.C

; Gaglieri, Caroline

; Ferreira, Laura T.

; Marques, Rodrigo F.C.

; Magdalena, Aroldo G.

Materials Research

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2022, Volume 25 elocation e20220312

Abstract: En | Text: En | PDF: En

Abstract The surface of Fe3O4 nanoparticles is very reactive and can oxidize to γ-Fe2O3 (maghemite) and α-Fe2O3 (hematite) structures. Based on this, the oxidation process of Fe3O4 nanoparticles must be prevented, and one of the strategies is surface functionalization with organic or inorganic molecules. Thus, this study analyzed the thermal behavior of Fe3O4 and Fe3O4-EDTA nanoparticles using X-ray diffraction (XRD), simultaneous thermogravimetry-differential thermal analysis (TG-DTA), differential scanning calorimetry (DSC). Results showed that γ- Fe2O3 was obtained as an intermediate in Fe3O4 and Fe3O4-EDTA decomposition, as confirmed by TG-DTA and DSC curves. Moreover, Fe3O4-EDTA exhibited a temperature peak (Tp = 573.5°C) of phase transformation (γ-Fe2O3 → α-Fe2O3) higher than that of Fe3O4 (Tp = 533.0°C), confirming that EDTA molecules stabilized the nanoparticles efficiently. The kinetic behavior of samples changed, and the activation energy for functionalized samples decreased.

https://doi.org/10.1590/1980-5373-mr-2022-0312

HIV knowledge and its correlation with the Undetectable = Untransmittable slogan in Brazil
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Ferreira, Rayane C.

; Torres, Thiago Silva

; Marins, Luana Monteiro Spindola

; Ceccato, Maria das Graças B.

; Bezerra, Daniel R. B.

; Luz, Paula M.

Revista de Saúde Pública

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2022, Volume 56 elocation 87

Abstract: En | Text: En | PDF: En

ABSTRACT Knowledge about HIV transmission and prevention is a necessary step for adopting preventive behaviors. We assessed HIV knowledge and its correlation with the perceived accuracy of the “Undetectable = Untransmittable” (U=U) slogan in an online sample with 401 adult Brazilians. Overall, 28% of participants showed high HIV knowledge level. The perceived accuracy of the U=U slogan significantly correlated with HIV knowledge. Younger participants, those reporting lower income or lower education, or who had never tested for HIV showed poorer HIV knowledge. Filling gaps of knowledge among specific populations is urgent in order to increase preventive behaviors and decrease HIV stigma.

https://doi.org/10.11606/s1518-8787.2022056004168

HIV knowledge and its correlation with the Undetectable = Untransmittable slogan in Brazil
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Ferreira, Rayane C.

; Torres, Thiago Silva

; Marins, Luana Monteiro Spindola

; Ceccato, Maria das Graças B.

; Bezerra, Daniel R. B.

; Luz, Paula M.

Revista de Saúde Pública

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2022, Volume 56 elocation 87

Abstract: En | Text: En | PDF: En

https://doi.org/10.11606/s1518-8787.2022056004168

10.

Design of an Antipodal Vivaldi Antenna Focusing on Constructional Aspects
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Cabral, David S.

; Manera, Leandro

; Zoccal, Leonardo B.

; Ferreira, Daniel B.

; Prudenzano, Francesco

Journal of Microwaves, Optoelectronics and Electromagnetic Applications

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dec 2021, Volume 20 N. 4 Pages 777 - 789

Abstract: En | Text: En | PDF: En

Abstract This paper presents an Antipodal Vivaldi Antenna (AVA) design, focusing on its constructional aspects. The main features analysed are the connector attachment structure and the introduction of a polytetrafluoroethylene (PTFE) part that supports the antenna laminate. Issues related to dielectric penetration by milling tools are also addressed. The proposed AVA was manufactured through a low-cost prototyping process and tested, achieving an operational bandwidth from 5 to 18 GHz for a reflection coefficient less than −10 dB and an average gain of 6.23 dBi. The prototype meets all design requirements, which shows the viability of the developed radiator.

https://doi.org/10.1590/2179-10742021v20i41270

11.

Posicionamento sobre Avaliação Pré-participação Cardiológica após a Covid-19: Orientações para Retorno à Prática de Exercícios Físicos e Esportes – 2020
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Colombo, Cléa Simone Sabino de Souza

; Leitão, Marcelo Bichels

; Avanza Junior, Antônio Carlos

; Borges, Serafim Ferreira

; Silveira, Anderson Donelli da

; Braga, Fabrício

; Camarozano, Ana Cristina

; Kopiler, Daniel Arkader

; Lazzoli, José Kawazoe

; Freitas, Odilon Gariglio Alvarenga de

; Grossman, Gabriel Blacher

; Milani, Mauricio

; Nunes, Mauricio B.

; Ritt, Luiz Eduardo Fonteles

; Sellera, Carlos Alberto Cyrillo

; Ghorayeb, Nabil

Arquivos Brasileiros de Cardiologia

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jun 2021, Volume 116 N. 6 Pages 1213 - 1226

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

https://doi.org/10.36660/abc.20210368 645 downloads

12.

High-concentrate diets with fibrous by-products for feedlot Nellore heifers
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CLEEF, ERIC H.C.B. VAN

; OLIVEIRA, PRISCILA S.N. DE

; GALATI, ROSEMARY LAÍS

; FERREIRA, DANIEL S.

; SANTOS, VIVIANE C.

; HOMEM JUNIOR, ANTÔNIO CARLOS

; PEREIRA JUNIOR, SERGIO ANTÔNIO G.

; PARDO, RENÉ MAURICIO P.

; EZEQUIEL, JANE MARIA B.

Anais da Academia Brasileira de Ciências

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2021, Volume 93 N. 3 elocation e20190731

Abstract: En | Text: En | PDF: En

Abstract The objective of this study was to evaluate high-concentrate diets and two energy sources on intake, performance and meat quality parameters of feedlot Nellore heifers. Twenty-eight heifers (200 ± 22.5 kg BW) were randomly assigned to four treatments in a 2×2 factorial arrangement: two concentrate levels (70 and 80%) and two energy sources (corn and corn germ meal). At the end of day 112, heifers were slaughtered. There was no interaction (P>0.05) of concentrate levels and energy sources for dry matter intake, unlike crude protein (CP) and neutral detergent fiber (NDF) intakes. The concentrate level of 80% and corn, allowed the highest CP (1.17 kg/day) and NDF (4.05 kg/day) intakes. Final BW (P<0.05) and daily gain (P<0.01) were influenced just by energy source. The carcass composition represented by muscle and fat was affected by concentrate level (P<0.05). Treatments affected (P<0.01) carcass fat deposition, global preference and texture of Longissimus muscle (P<0.05). It was concluded that high proportions of concentrate containing corn as energy source provided the best performance in heifers, and that the total replacement of corn with corn germ meal in high-concentrate diets is not recommended for performance Nellore heifers, but provided good sensory quality to the meat.

https://doi.org/10.1590/0001-3765202120190731 379 downloads

13.

MUCOPOLYSACARIDOSIS TYPE IIIB MISDIAGNOSED AS AN AUTISTIC SPECTRUM DISORDER: A CASE REPORT AND LITERATURE REVIEW
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Irigonhê, Alan Tibério Dalpiaz

; Moreira, Angélica Malman Thomazine

; Valle, Daniel Almeida do

; Santos, Mara Lúcia Schmitz Ferreira

Revista Paulista de Pediatria

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2021, Volume 39 elocation e2019397

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Objetivo: Relatar o caso raro de um paciente pediátrico com mucopolissacaridose III B, com ênfase na descrição de manifestações clínicas. Descrição do caso: Paciente masculino de 14 anos que, a partir dos 3 anos e 6 meses de idade, apresentou regressão do desenvolvimento neuropsicomotor, com perda da fala e quedas frequentes, evoluindo com alterações comportamentais, agitação e agressividade. Diagnosticado como autista, não obteve resposta ao tratamento estabelecido, sendo posteriormente submetido à investigação metabólica, que evidenciou o diagnóstico de mucopolissacaridose III B. Comentários: A identificação de um distúrbio metabólico exige conectar vários sinais e sintomas, além de eliminar outras causas aparentes. A mucopolissacaridose III B é um desafio diagnóstico, particularmente nos estágios iniciais e na ausência de história familiar da doença.

ABSTRACT Objective: To report a rare case of mucopolysaccharidosis IIIB in a pediatric patient, with emphasis on the description of the clinical manifestations and the early diagnosis. Case description: A 14-year-old male patient, who presented regression of neuropsychomotor development since his three years and six months old, with speech loss and frequent falls, evolving with behavioral changes, with agitation and aggressiveness. Although being diagnosed with autism, there was no response to the established treatment; he was subsequently submitted to metabolic investigation, which lead to the diagnosis of Mucopolysaccharidosis IIIB. Comments: Identifying a metabolic disorder requires connecting multiple signs and symptoms, as well as eliminating other apparent causes. MPS IIIB is a diagnostic challenge, particularly in the early stages and in the absence of a family history of the disease.

https://doi.org/10.1590/1984-0462/2021/39/2019397 1710 downloads

14.

Baryon Acoustic Oscillations from Integrated Neutral Gas Observations: an instrument to observe the 21cm hydrogen line in the redshift range 0.13 < z < 0.45 – status update
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WUENSCHE, CARLOS A.

; ABDALLA, ELCIO

; ABDALLA, FILIPE

; BAROSI, LUCIANO

; WANG, BIN

; AN, RUI

; BARRETOS, JOÃO A. M.

; BATTYE, RICHARD

; BRITO, FRANCISCO A.

; BROWNE, IAN

; CORREIA, DANIEL

; COSTA, ANDRÉ A.

; DELABROUILLE, JACQUES

; DICKINSON, CLIVE

; FENG, CHANG

; FERREIRA, ELISA G. M.

; FORNAZIER, KARIN

; DE GASPERIS, GIANCARLO

; GUTIERREZ, PRISCILA

; HARPER, STUART

; LANDIM, RICARDO G.

; LICCARDO, VINCENZO

; MA, YIN-ZHE

; MACHADO, TELMO

; MAFFEI, BRUNO

; MARINS, ALESSANDRO

; MENDES, MILENA M. M.

; MERICIA, EDUARDO

; MONSTEIN, CHRISTIAN

; MOTTA, PABLO

; NOVAES, CAMILA

; OTOBONE, CARLOS H.

; PEEL, MICHAEL

; QUEIROZ, AMILCAR R.

; RADCLIFFE, CHRISTOPHER

; REMAZEILLES, MATHIEU

; RIBEIRO, RAFAEL M. G.

; SANG, YU

; SANTOS, JULIANA F. R.

; SANTOS, LARISSA

; SANTOS, MARCELO. V.

; SHAN, CHENXI

; SILVA, GUSTAVO B.

; VIEIRA, FREDERICO

; VIEIRA, JORDANY

; VILLELA, THYRSO

; XIAO, LINFENG

; YANG, WEIQIANG

; ZHANG, JIAJUN

; ZHANG, XUE

; ZHU, ZENGHAO

Anais da Academia Brasileira de Ciências

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2021, Volume 93 elocation e20201096

Abstract: En | Text: En | PDF: En

Abstract BINGO (BAO from Integrated Neutral Gas Observations) is a unique radio telescope designed to map the intensity of neutral hydrogen distribution at cosmological distances, making the first detection of Baryon Acoustic Oscillations (BAO) in the frequency band 980 MHz - 1260 MHz, corresponding to a redshift range 0.127 < z < 0.449. BAO is one of the most powerful probes of cosmological parameters and BINGO was designed to detect the BAO signal to a level that makes it possible to put new constraints on the equation of state of dark energy. The telescope will be built in Paraíba, Brazil and consists of two \thicksim 40m mirrors, a feedhorn array of 50 horns, and no moving parts, working as a drift-scan instrument. It will cover a 15 ^{\circ} ∘ declination strip centered at \sim \delta ∼ δ =-15 ^{\circ} ∘, mapping \sim ∼ 5400 square degrees in the sky. The BINGO consortium is led by University of São Paulo with co-leadership at National Institute for Space Research and Campina Grande Federal University (Brazil). Telescope subsystems have already been fabricated and tested, and the dish and structure fabrication are expected to start in late 2020, as well as the road and terrain preparation.

https://doi.org/10.1590/0001-3765202120201096 413 downloads

15.

Compounds isolated from Bixa orellana: evidence-based advances to treat infectious diseases
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Nascimento Moraes Neto, Roberval

; Guedes Coutinho, Gabrielle

; de Oliveira Rezende, Aline

; de Brito Pontes, Daniel

; Pinheiro Soares Ferreira, Rayana Larissa

; de Araújo Morais, Danilo

; Pontes Albuquerque, Rafaela

; Lima-Neto, Lídio Gonçalves

; Nascimento da Silva, Luís Cláudio

; Quintino da Rocha, Cláudia

; Machado Gonçalves, Letícia

; Macedo Santiago, Luís Ângelo

; Mondego-Oliveira, Renata

; Cardoso Carvalho, Rafael

; de Sousa, Eduardo Martins

Revista Colombiana de Ciencias Químico - Farmacéuticas

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- Sobre o periódico
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dec 2020, Volume 49 N. 3 Pages 581 - 601

Abstract: Es En | Text: Es En | PDF: Es | PDF: En

RESUMEN Bixa orellana L. es una planta nativa de Brasil, pero también está presente en otros países tropicales como Perú, Colombia, Ecuador, México, Indonesia, India y África Oriental. Es conocida popularmente como Urucum en Brasil. Esta revisión expone el potencial de los compuestos bioactivos derivados de B. orellana para tratar enfermedades debido a sus propiedades antimicrobianas y antioxidantes. Esta planta también está relacionada como un agente antiinflamatorio para el tratamiento de enfermedades pulmonares e incluso como gotas para los ojos para el enrojecimiento. Sus hojas se utilizan para el tratamiento de la mordedura de serpiente, diarrea, gonorrea, hepatitis, gastritis, diuréticos, antipiréticos y para enfermedades de la piel. Ese conocimiento popular ha fomentado la identificación de compuestos bioactivos en esa planta. Los compuestos β-criptoxantina, geranilgeraniol, luteína, procianidina B2, procianidina B3, isómero elagitanino y ácido elágico desoxihexosa inhibieron microorganismos patógenos como bacterias, hongos, protozoos y virus. En ese sentido, B. orellana es una fuente prometedora de compuestos que podrían aplicarse en la terapia antimicrobiana. Este trabajo de revisión puede ayudar a comprender e incentivar nuevas investigaciones para los descubrimientos de antimicrobianos que utilizan diferentes compuestos de B. orellana.

SUMMARY Bixa orellana L. is a native plant from Brazil, but it is also present in other tropical countries such as Peru, Colombia, Ecuador, Mexico, Indonesia, India and East Africa. It is popularly known as Urucum in Brazil. This review shows the potential of bioactive compounds derived from B. orellana to treat infectious diseases due their antimicrobial and antioxidant properties. This plant is also related as an antiinflammatory agent for treatment of pulmonary diseases, or even as eye drops for redness. Its leaves are used for treatment of snakebite, diarrhea, gonorrhea, hepatitis, gastritis, diuretic, antipyretic, and for skin disease. This popular knowledge has encouraged the identification of bioactive compounds in this plant. Compounds as β-cryptoxanthin, geranylgeraniol, lutein, procyanidin B2, procyanidin B3, ellagi tannin isomer and ellagic acid deoxyhexose have been described. These compounds inhibited pathogenic microorganisms such as bacteria, fungi, protozoan and viruses. In addition, some compounds with anti-inflammatory and antioxidant activities were also described. In this sense, B. orellana is a promising source of compounds that could be applied in antimicrobial therapy. This review work may help in the understanding and incentive of new research for antimicrobial discoveries using different B. orellana compounds.

https://doi.org/10.15446/rcciquifa.v49n3.91247 306 downloads

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