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Resumo Introdução: A leishmaniose é uma possível preocupação para receptores de transplante de órgãos sólidos (TOS), especialmente aqueles provenientes de regiões endêmicas. Dentre os procedimentos de TOS, o transplante renal (TR) é o mais comum. Este estudo tem como objetivo sintetizar as evidências sobre leishmaniose visceral (LV) em candidatos e receptores de TR, com foco nos fatores de risco e desfechos associados. Metodos: Esta revisão integrativa analisou estudos dos últimos 20 anos, concentrando-se no perfil da doença, tratamento, prognóstico e risco de infecção assintomática. Resultados: Foram incluídos 32 artigos. Dos receptores de TR, 85,7% eram do sexo masculino, com idade média de 42,5 anos. O tempo médio desde o início dos sintomas foi de 54,7 meses. O comprometimento da função renal foi relatado em 64% dos pacientes, com uma taxa de mortalidade associada de 15%. A recidiva pós-tratamento ocorreu em 10-37,5% dos pacientes. Entre os candidatos ao TR, 13,9% apresentaram soropositividade para Leishmania spp. Conclusão: A LV é uma condição pouco frequente entre receptores de TR, o que limita a qualidade das evidências disponíveis. A detecção precoce e o tratamento imediato são cruciais para a melhoria dos desfechos. Embora o comprometimento da função renal seja comum, ele raramente leva à rejeição do enxerto. Nos estudos revisados, a coexistência de LV e formas cutâneas ou mucocutâneas esteve associada a maior mortalidade. As recidivas são comuns e exigem estratégias de manejo individualizadas. A hemotransfusão representa um potencial risco de infecção, embora a triagem de rotina em bancos de sangue ainda não seja recomendada.

Abstract Introduction: Leishmaniasis is a potential concern for solid organ transplant (SOT) recipients, particularly those from endemic regions. Among SOT procedures, kidney transplantation (KT) is the most common. This study aims to synthesize the evidence about visceral leishmaniasis (VL) in KT candidates and recipients, with a focus on risk factors and associated outcomes. Methods: This integrative review analyzed studies from the past 20 years, focusing on disease profile, treatment, prognosis, and risk of asymptomatic infection. Results: A total of 32 articles were included. Of the KT recipients, 85.7% were male, with an average age of 42.5 years. The average timespan since symptom onset was 54.7 months. Renal function impairment was reported in 64% of patients, with an associated mortality rate of 15%. Post-treatment relapse occurred in 10–37.5% of patients. Among KT candidates, 13.9% were seropositive for Leishmania spp. Conclusion: VL is an infrequent condition among KT recipients, limiting the quality of the available evidence. Early detection and prompt treatment are crucial for improving outcomes. While renal function impairment is common, it rarely leads to graft rejection. In the reviewed studies, the coexistence of VL and cutaneous or mucocutaneous forms was linked to higher mortality. Recurrences are common and require individualized management strategies. Hemotransfusion poses a potential infection risk, although routine screening in blood banks is not yet recommended.

https://doi.org/10.1590/2175-8239-jbn-2024-0138en

[SciELO Preprints] - Assessing perceived stress in people with hard-to-heal wounds: cases series
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Costa Ferreira, Beatriz Viviana Serna González, Carol Yamada, Beatriz Conceição de Gouveia Santos, Vera Lucia

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Publication date: 2025-03-14

Abstract: Es Pt En

Objetivo: Ejemplificar la valoración del estrés, distrés, y coping percebidos por pacientes con heridas de difícil cicatrización (HDC), atendidos en un servicio de Terapia Enterostomal: heridas, ostomias e incontinencias. Método: Estudio secundario, observacional y prospectivo de 10 pacientes adultos con HDC, atendidos entre dos a seis consultas. Fueron aplicados el Formulário de datos sociodemográficos y clínicos; el Inventario Breve del Dor (sensibilidad - BPIS e interferencia - BPII); el Instrumento de Valoración de la Herida de Bates Jensen – BWAT; y la Escala de Estrés Percebido - PSS, la cual incluye coping e distrés. Los datos fueron expresados en promedios. Resultados: Los pacientes tenían HDC principalmente en los membros inferiores, con duración de 21,2 meses; BWAT 23,7; BPIS 4; BPII 3,2. El estrés fue caracterizado por un PSS total de 28,5 puntos, con coping 16 y distrés de 16,4 puntos. En la última consulta fue identificada la diminuición de 4,3 pontos en la BWAT; 0,8 en la BPIS; 7,6 puntos en la PSS con 5,3 en el distrés. La BPII aumentó 0,7 y el coping 2,2. Conclusión: La herida parece interferir en el nivel de estrés percibido, es decir, en la dimensión biopsicosocial del paciente. El coping destaca como factor determinante en la percepción del estrés y es esencial un enfoque multidisciplinar para su gestión y para evaluar el distrés.

Objetivo: Exemplificar a avaliação do estresse, distresse e coping percebidos por pacientes com feridas de difícil cicatrização (FDC), atendidos em ambulatório de Estomaterapia. Método: Estudo secundário, observacional e prospectivo de 10 pacientes adultos com FDC, acompanhados durante duas a seis consultas. Foram utilizados Formulário de dados sociodemográficos e clínicos; Inventário Breve de Dor (sensibilidade - BPIS e interferência - BPII); Instrumento de Avaliação da Ferida da Bates Jensen – BWAT e Escala de Estresse Percebido - PSS, incluindo coping e distresse, com dados expressos em médias. Resultados: Os pacientes tinham FDC principalmente em membro inferior, com duração de 21,2 meses; BWAT 23,7; BPIS 4; BPII 3,2. O estresse foi caracterizado por PSS total de 28,5 pontos, distresse de 16,4 e coping 16. Na última consulta foi observada diminuição de 4,3 pontos na BWAT; 0,8 na BPIS; 7,6 pontos na PSS com 5,3 no distresse. A BPII aumentou 0,7 e o coping 2,2. Conclusão: A ferida parece interferir no nível de estresse percebido, ou seja, na dimensão biopsicossocial do paciente. O coping se destaca como um fator determinante na percepção do estresse e uma abordagem multidisciplinar é essencial para o seu manejo e para a avaliação do distresse.

Objective: To exemplify the stress, distress, and coping assessment perceived by patients with hard-to-heal wounds (HHW) receiving treatment in a Stomatherapy outpatient clinic. Methods: Observational, prospective secondary study involved 10 adult patients with HHW, who were followed over two to six consultations. The following tools were used: sociodemographic and clinical data form; Brief Pain Inventory (sensitivity - BPI-S and interference - BPI-I); Bates-Jensen Wound Assessment Tool (BWAT); Perceived Stress Scale (PSS), which included measures of coping and distress with data expressed as means. Results: Patients primarily had HHW located on the lower extremities, with a duration of 21.2 months; BWAT score was 23.7; BPI-S was 4; and BPI-I was 3.2. Stress was characterized by a total PSS score of 28.5 points, with a distress score of 16.4 and a coping score of 16. In the final consultation, there was a decrease of 4.3 points in BWAT; 0.8 points in BPI-S; and 7.6 points in PSS, with a 5.3 point reduction in distress. The BPI-I increased by 0.7, and coping improved by 2.2. Conclusion: The wound seems to interfere with the level of perceived stress, i.e. the patient's biopsychosocial dimension. Coping stands out as a determining factor in the perception of stress, and a multidisciplinary approach is essential for its management and assessment of distress.

https://doi.org/10.1590/SciELOPreprints.11419

The current paradigm of Parvovirus B19 infection in pregnancy
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Boas, Beatriz Vilas

; Duarte, Ana Luísa Ferreira, Dânia Bivar, Leonor Macedo de Cardoso, Luísa

Acta Obstétrica e Ginecológica Portuguesa

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mar 2025, Volume 19 N. 1 Pages 32 - 39

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo O parvovírus B19 afeta 1-3% das grávidas, com transmissão a 17-33% dos fetos. O gold standard para diagnóstico de infeção materna são as serologias IgG/IgM. A maioria das infeções fetais é autolimitada; contudo, a vigilância fetal ecográfica com avaliação do pico de velocidade sistólica da artéria cerebral média (PVS-ACM) é essencial na deteção de anemia e hidrópsia fetal. Um PVS-ACM > 1,5 MoM determina a realização de transfusão intrauterina, o que diminui a mortalidade fetal. A hidrópsia fetal associa-se a desfechos pós-natais desfavoráveis e um risco aumentado de alterações neurológicas e de neurodesenvolvimento. Ainda assim, o prognóstico é geralmente favorável.

Abstract Parvovirus B19 may affect 1-3% of pregnant women, with vertical transmission occurring in 17-33% of these cases. The gold standard for diagnosing maternal infection is IgG/IgM serology testing. Most fetal infections are self-limited; however, fetal surveillance through ultrasound-based methods, including the assessment of middle cerebral artery peak systolic velocity (MCA-PSV), aims to detect the presence of anemia and fetal hydrops. An MCA-PSV > 1.5 MoM indicates the need for intrauterine transfusion, which improves mortality rates. Fetal hydrops is associated with worse postnatal outcomes and a higher risk of neurological and neurodevelopmental alterations. Nevertheless, the prognosis is generally favorable.

https://doi.org/10.69729/aogp.v19i1a04

Impacto do modelo ECHO® no acompanhamento de pessoas com diagnóstico de diabetes mellitus: revisão de escopo
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Souza, Isla Evellen Santos

; Silva, Marcela Santos da

; Araújo, Cindy Kemille Andrade de

; Ferreira, Beatriz Carvalho

; Cardoso, Alice

; Silva, Glebson Moura

; Otero, Liudmila Miyar

Ciência & Saúde Coletiva

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jan 2025, Volume 30 N. 1 elocation e14792023

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

Resumo A presente revisão teve como objetivo identificar o impacto do modelo ECHO® no acompanhamento de pessoas com diagnóstico de diabetes mellitus. O trabalho foi desenvolvido de acordo com as recomendações do Joanna Briggs Institute e do Checklist PRISMA-ScR, cujas buscas foram realizadas nas bases de dados Cochrane Library, Embase, Biblioteca Virtual em Saúde, PubMed/MEDLINE, Scopus e Web of Science, por meio de estratégias compostas pelos descritores “Diabetes mellitus”, “Diabete Melito”, “Diabetes”, “Diabetes Melito”, “model ECHO”, “Project ECHO” e “Extension for Community Healthcare Outcomes”. A seleção dos estudos contou com dois revisores trabalhando de forma independente através do software de gestão Rayyan-Intelligent Systematic Review. Dos 151 trabalhos identificados, nove foram selecionados. Um estudo foi identificado na literatura cinzenta. Os dez estudos incluídos foram publicados em inglês, entre os anos de 2012 a 2022. Observou-se melhorias no conhecimento e na autoconfiança dos profissionais, além de diminuição da hemoglobina glicada, redução de hospitalizações e de gastos com internações das pessoas com diabetes. Conclui-se que este trabalho expõe um impacto positivo do Modelo ECHO® no acompanhamento de pessoas com diabetes mellitus, principalmente em comunidades de maior vulnerabilidade.

Abstract This review aimed to identify the impact of the ECHO® model on monitoring people diagnosed with diabetes mellitus. It followed the Joanna Briggs Institute and the PRISMA-ScR Checklist. The search was conducted in the Cochrane Library, Embase, Virtual Health Library, PubMed/MEDLINE, Scopus, and Web of Science databases. The strategy included the descriptors “Diabetes mellitus,” “Diabetes Melito,” “Diabetes,” “Diabetes Melito,” “Model ECHO,” “Project ECHO,” and “Extension for Community Healthcare Outcomes.” Two independent reviewers selected the studies using the Rayyan-Intelligent Systematic Review management software. Nine of the 151 studies initially identified were selected, and one study was identified through gray literature. The ten studies were published in English between 2012 and 2022. Improvements were found in the professionals’ knowledge and self-confidence, besides decreased glycated hemoglobin levels, hospital admissions, and hospitalization costs among people with diabetes. The conclusion is that the ECHO® Model positively impacted the monitoring of people with diabetes mellitus, especially in vulnerable communities.

Resumen La presente revisión tuvo como objetivo identificar el impacto del modelo ECHO® en el seguimiento de personas diagnosticadas con diabetes mellitus. El trabajo se desarrolló de acuerdo con las recomendaciones del Instituto Joanna Briggs y el PRISMA-ScR Checklist, cuyas búsquedas se realizaron en las bases de datos Cochrane Library, Embase, Biblioteca Virtual de Salud (BVS), PubMed/MEDLINE, Scopus y Web of Science, mediante estrategias compuestas por los descriptores “Diabetes mellitus”, “Diabete Melito”, “Diabetes”, “Diabetes Melito”, “model ECHO”, “Project ECHO” y “Extension for Community Healthcare Outcomes”. La selección de estudios incluyó a dos revisores que trabajaron de forma independiente utilizando el software de gestión Rayyan-Intelligent Systematic Review. Se seleccionaron nueve de las 151 obras identificadas y se identificó un estudio por medio de la literatura gris. Los diez estudios incluidos fueron publicados en inglés entre 2012 y 2022. Se observaron mejoras en el conocimiento y la confianza en sí mismos de los profesionales, además de una reducción de la hemoglobina glucosilada, de las hospitalizaciones y de los costos de hospitalización de las personas con diabetes. Se concluye que este trabajo expuso un impacto positivo del Modelo ECHO® en el seguimiento de personas con diabetes mellitus, especialmente en comunidades más vulnerables.

https://doi.org/10.1590/1413-81232025301.14792023

Impacto do modelo ECHO® no acompanhamento de pessoas com diagnóstico de diabetes mellitus: revisão de escopo
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Souza, Isla Evellen Santos

; Silva, Marcela Santos da

; Araújo, Cindy Kemille Andrade de

; Ferreira, Beatriz Carvalho

; Cardoso, Alice

; Silva, Glebson Moura

; Otero, Liudmila Miyar

Ciência & Saúde Coletiva

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2025, Volume 30 N. 1 elocation e14792023

Abstract: Pt Es En | Text: Pt Es En | PDF: Pt | PDF: Es | PDF: En

https://doi.org/10.1590/1413-81232025301.14792023

Intersectionality and mental health in university students: a jeopardy index approach
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Lima, Juliana Dias de

; Plácido, Jessica

; Andrade, Beatriz

; Abend, Letícia Dalcero

; Waclawovsky, Aline Josiane

; Pires, Daniel Alves

; Silva, Danilo Rodrigues Pereira da

; Jesus-Moraleida, Fabianna Resende de

; Moura, Helena Ferreira

; Coelho, Nicole Leite Galvão

; Monteiro-Junior, Renato Sobral

; Matias, Thiago Sousa

; Schuch, Felipe Barreto

; Deslandes, Andrea Camaz

Revista de Saúde Pública

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2025, Volume 59 elocation e3

Abstract: En | Text: En | PDF: En

ABSTRACT OBJECTIVE: To explore the associations between current mental health symptoms and social disparities in university students. METHODS: We recruited participants from nine public universities in Brazil, from August to November 2022, using online advertisements and in-person lectures. All participants completed an online survey containing social (sex, race/color, gender identity, sexual orientation, and income) and mental health assessments. The Jeopardy index was composed of social variables. The index considered zero points for subjects with less oppressive experienced characteristics (men, White, cisgender, heterosexual, higher income) and one point for the opposite characteristics. We defined six clusters according to Jeopardy Index results: 0, 1, 2, 3, 4, and 5 points, with the greatest number of points representing the most disadvantaged group. The mental health symptoms were assessed on two levels. First by the “DSM-5 Self-Rated Level 1 Cross-Cutting Symptom Measure – Adult,” and second by the “Patient Health Questionnaire-9,” and the “Generalized Anxiety Disorder Questionnaire-7.” Adjusted Odds Ratio (OR) analyses was performed for age and educational level. RESULTS: 748 participants were allocated into the six Jeopardy clusters: 0 (n = 46; 6.1%), 1 (n = 112; 15.0%), 2 (n = 163; 21.8%), 3 (n = 218; 29.1%), 4 (n = 171; 22.9%), and 5 (n = 38; 5.1%). It was observed a high prevalence of anxiety (42.5%) and depression (51.0%), however, the less privileged group (5) had a higher risk of having severe symptoms of anxiety (OR = 6.21; 1.51–25.58; p < 0.01) and depression (OR = 8.60; 2.15–34.43; p < 0.01), compared against the most privileged group. CONCLUSION: Although anxiety and depressive symptoms were highly prevalent for all participants, these disorders are not equally distributed in this population and the intersectionality between social factors plays an important role in contributing to these differences.

https://doi.org/10.11606/s1518-8787.2025059006197

Effects of iron and copper on emergence and physiology of Canavalia ensiformis (l.) DC
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Carvalho, Isabella F. de

; Alves, Patrícia B.

; Ferreira, Tássia C.

; Santos, Beatriz S. dos

; Cozin, Bruno B.

; Souza, Roberta P. de

; Camargos, Liliane S.

Revista Caatinga

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2025, Volume 38 elocation e12686

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

ABSTRACT Plants require iron (Fe) and copper (Cu) at low concentrations for metabolic functions; however, excess soil Fe and Cu can cause toxicity and affect plant development. The objective of this study was to assess the effects of soil Cu and Fe concentrations on seedling emergence, as well as on the metabolism of the main reserve compounds and the biomass in roots, stems, leaves, and cotyledons of Canavalia ensiformis. A greenhouse experiment was conducted in a completely randomized design; the Cu and Fe treatments in the soil were: (control, 50, 150, 250 and 350 mg dm-3) over a period of 10 days. Seedling emergence was not affected by the evaluated treatments; however, the results showed an increase in the emergence speed index (EVI) for the Fe treatment at a dose of 150 mg dm-3 of soil compared to 350 mg dm-3 of soil. Treatment with Cu at a dose of 350 mg dm-3 of soil reduced root length. Cu treatments reduced root dry mass. Fe treatments affected the content of soluble amino acids in the stems, leaves and cotyledons, as well as the total soluble proteins in the cotyledons and the carbohydrate content in the leaves. Cu treatments increased protein and carbohydrate content in leaves and starch content in cotyledons. High concentrations of Cu and Fe modify the production of nitrogenous compounds in the plant and reduce root biomass.

RESUMO As plantas necessitam de ferro (Fe) e cobre (Cu) em baixas concentrações para realizar funções metabólicas. Porém, o excesso de Fe e Cu no solo pode causar toxicidade e afetar o desenvolvimento das plantas. O objetivo desse estudo foi avaliar os efeitos das concentrações de Cu e Fe no solo na emergência das plântulas, bem como no metabolismo dos principais compostos de reserva e na biomassa de raízes, caules, folhas e cotilédones de Canavalia ensiformis. O experimento foi conduzido em casa de vegetação, em delineamento inteiramente casualizado; os tratamentos de Cu e Fe no solo foram: (controle, 50, 150, 250 e 350 mg dm-3) durante um período de 10 dias. A emergência das plântulas não foi afetada pelos tratamentos avaliados; entretanto, os resultados mostraram aumento do índice de velocidade de emergência (EVI) para o tratamento com Fe na dose de 150 mg dm-3 de solo em comparação com 350 mg dm-3 de solo. O tratamento com Cu na dose de 350 mg dm-3 de solo reduziu o comprimento das raízes. Os tratamentos com Cu reduziram a massa seca das raízes. Os tratamentos com Fe afetaram o conteúdo de aminoácidos solúveis nos caules, folhas e cotilédones, bem como as proteínas solúveis totais nos cotilédones e o conteúdo de carboidrato nas folhas. Os tratamentos com Cu aumentaram os teores de proteínas e carboidratos nas folhas e o teor de amido nos cotilédones. Altas concentrações de Cu e Fe modificam a produção de compostos nitrogenados na planta e diminuem a biomassa radicular.

https://doi.org/10.1590/1983-21252025v3812686rc

Dye Contaminant Removal: Adsorption on Thermoplastic Starch/Kraft Lignin Composites and Photodegradation
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Freitas, Amanda S. M. de

; Rodrigues, Jéssica S.

; Amaro, Stefanny F.

; Ramos, Beatriz M.

; Ferreira, Marystela

Journal of the Brazilian Chemical Society

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2025, Volume 36 N. 5 elocation e-20240197

Abstract: En | Text: En | PDF: En

This study investigated the removal of contaminants in water by adsorption on thermoplastic starch (TPS) and kraft lignin (KL) composites. A study on the desorption of methylene blue (MB) and methyl orange (MO) dyes in water was also carried out, followed by the photodegradation of solutions containing dissolved dyes. Initially, the surface morphology of the TPS and TPS-KL films was analyzed by scanning electron microscopy, revealing advantageous characteristics for efficient adsorption of contaminants. Fourier transform infrared spectroscopy (FTIR) analysis made it possible to characterize the TPS and TPS-KL composites. The results demonstrate the reversibility of the process and confirm the lack of permanent chemical modification in the polymer matrix, indicating that the adsorption/desorption process is physical rather than chemical. This suggests that the adsorbent material can be reused without losing its fundamental structural properties. Furthermore, the study allows for verification of the chemical changes on the surfaces of the materials involved. Ultraviolet-visible spectroscopy (UV-Vis) results show that for MO, both substrates exhibited low adsorption capacity, with efficiency values close to 20%. In contrast, for MB, both composite materials displayed excellent dye adsorption rates, achieving efficiencies of 78% or higher. The photodegradation of adsorbed dyes revealed promising results.

https://doi.org/10.21577/0103-5053.20240197

Trend and high risk clusters for the occurrence of congenital anomalies in the State of Mato Grosso, Brazil (2008-2019)
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Groth, Bruna Rayeli

; Silva, Eliziani Gonçalves da

; Rocha, Camila Beatriz Alves da

; Freitas, Bruna Hinnah Borges Martins de

; Machado, Rafaela Benevides Ferreira

; Ferreira, Elena Alves Benevides

; Machado, Lúbia Maieles Gomes

; Santos, Emerson Soares dos

; Battisti, Iara Denise Endruweit

; Ferreira, Silvana Margarida Benevides

Revista Brasileira de Saúde Materno Infantil

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2025, Volume 25 elocation e20240111

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Objetivos: analisar a dinâmica espaço-temporal da prevalência de anomalias congênitas em municípios de Mato Grosso (MT), Centro-Oeste brasileiro, no período de 2008 a 2019. Métodos: estudo ecológico de casos residentes em MT, no período de 2008 a 2019. Utilizou-se a Variação Percentual Anual (VPA) dos coeficientes na análise de tendência, por meio de regressão de Prais-Winsten e identificação de clusters de alto risco. Resultados: a taxa de malformação congênita no estado foi de 6,52 por 1.000 nascidos vivos, apresentando tendência estacionária (VPA= -1,02; IC95%= -2,93-0,93). A maioria das anomalias congênitas apresentou tendência estacionária, exceto do aparelho cardiovascular (VPA=13,58; IC95%= 3,60-24,52). Neonatos com ≤7 pontos do índice de Apgar no primeiro e no quinto minutos de vida, apresentaram tendência crescente (VPA=2,30; IC95%= 0,05-4,60 e VPA=4,15; IC95%= 1,52-6,65, respectivamente). A distribuição espacial teve caráter heterogêneo com as maiores taxas médias de casos entre as macrorregiões de saúde Oeste, Centro-Norte e Sul, e a varredura espaço-temporal identificou três clusters de alto risco entre 2015 e 2019, com RR de até cinco vezes maior para anomalias. Conclusão: as anomalias congênitas em MT apresentaram uma dinâmica heterogênea com áreas de alto risco específicas. A tendência crescente entre fatores maternos e neonatais destaca a necessidade de estratégias regionais de prevenção e controle.

Abstract Objectives: to analyze the spatiotemporal dynamics of the prevalence of congenital anomalies in in cities of Mato Grosso (MT), in the Mid-West of Brazil, from 2008 to 2019. Methods: an ecological study of cases in MT during the period from 2008 to 2019. The Annual Percent Change (APC) of the coefficients was used in the tendency analysis, through Prais-Winsten regression and the identification of high risk clusters. Results: the congenital malformation rate in the State was 6.52 per 1,000 live births, demonstrating a stationary tendency (APC-1.02; 95%CI= -2.93-0.93). Most congenital anomalies showed a stationary tendency, except for those of the cardiovascular system (APC=13.58; 95%CI= 3.60-24.52). Newborns with an Apgar score of ≤ 7 at the first and fifth minutes of life showed an increased tendency (APC=2.30; 95%CI=0.05-4.60 and APC=4.15; 95%CI= 1.52-6.65, respectively). The spatial distribution was heterogeneous, with the highest average rates of cases in the West, Central North, and South health macro-regions. The spatiotemporal scan identified three high risk clusters between 2015 and 2019, with a relative risk (RR) up to five times higher for anomalies. Conclusion: congenital anomalies in MT exhibited a heterogeneous dynamic with specific high risk areas, and their increasing tendency among maternal and neonatal factors highlights the need for regional prevention and control strategies.

https://doi.org/10.1590/1806-9304202500000111-en

10.

Evaluation of epithelial-to-mesenchymal transition and Ki-67 index in aggressive papillary thyroid cancer
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Camilo, Luana Perrone

; Vianna, Paula

; Alves, Venancio Avancini Ferreira

; Cavalheiro, Beatriz Godoi

; Rossetti, Carlos Augusto

; Kowalski, Luiz Paulo

; Matos, Leandro Luongo

; Leite, Ana Kober Nogueira

Brazilian Journal of Otorhinolaryngology

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2025, Volume 91 elocation 101510

Abstract: En | Text: En | PDF: En

Abstract Objectives The present study aims to characterize immunohistochemical features of markers associated with Epithelial-Mesenchymal Transition (EMT) and proliferative activity that could lead to death in Papillary Thyroid Cancer (PTC). Methods Clinical data and tumor material were retrospectively collected. The patients were separated into death from PTC (Group 1), metastatic cases with indolent behavior (Group 2) and non-metastatic indolent PTC (Group 3). Immunohistochemical assessment of E-cadherin, β-catenin, Vimentin, ZEB-1 and Ki-67 was performed in each tumor and a semiquantitative estimation of the percentage of expression was fulfilled on the best marking area at high of the tumor invasion front. Results 31 patients were included, 15 that died from PTC (Group 1), 6 in Group 2 and 10 in Group 3. The proliferative marker Ki-67 showed a significant difference in its expression in the tumor invasion front between the groups, specifically between groups 1 and 3 (p= 0.006). On the other hand, EMT-related immunohistochemical markers did not show significant difference in their percentage of expression, since loss of E-cadherin, β-catenin and Vimentin was observed in most cases at the invasion front. Conclusion Patients that died from PTC had a significantly higher Ki-67 labelling index compared to patients with indolent disease (cutoff of 11%). Ki-67 may have a role as a prognostic marker and could be considered for routine use in PTC. Level of evidence: 4.

https://doi.org/10.1016/j.bjorl.2024.101510

11.

Occlusion, acid resistance, and elemental characterization of dentin treated with desensitizing agents
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RIBEIRO, Maria Carolina Lopes de Souza

; FERREIRA, Beatriz Araújo Jacinto

; RIBEIRO, Ana Carolina Freitas

; FRANÇA, Fabiana Mantovani Gomes

; TURSSi, Cecilia Pedroso

; BASTING, Roberta Tarkany

; VIEIRA-JUNIOR, Waldemir Francisco

Brazilian Oral Research

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2025, Volume 39 elocation e016

Abstract: En | Text: En | PDF: En

Abstract The objective of this study was to evaluate the occlusion potential of in-office desensitizing agents, and characterize the human dentin elements after acid exposure. Twelve human dentin discs were sectioned into four specimens each, and randomized into treatments (n = 20): no treatment (negative control); no treatment and 6% citric acid exposure (positive control); application of Gluma desensitizer (Heraeus Kulzer) or PRG Barrier Coat (Shofu), followed by 6% citric acid exposure. Occlusion and dentin surface characteristics were determined by scanning electron microscopy (SEM, n = 10), and elemental composition (at%), by energy-dispersive X-ray spectroscopy (EDS, n = 10). Three calibrated, blinded evaluators used SEM to categorize the occlusion potential: 1 = occluded, 2 = partially unoccluded, 3 = equally occluded/unoccluded, 4 = partially occluded, 5 = unoccluded. Data were analyzed by weighted kappa, Friedman, and Nemenyi tests (α = 0.05). For SEM, mean occlusion scores were higher for the PRG Barrier Coat than the positive control (p = 0.0235). Most specimens in the controls scored 4 or 5. The most frequent scores for PRG Barrier Coat were 1(60%) and 2(20%), while 30% of Gluma specimens scored 1 and 2. Gluma showed intratubular precipitation, while PRG Barrier Coat covered dentinal tubules totally or partially. For EDS, the K% was lower for Gluma than the negative control (p = 0.0046), with Si peaks in dentin treated with PRG Barrier Coat. The bioactive in-office desensitizing agent with S-PRG filler (PRG Barrier Coat) promoted dentin tubule occlusion, and persisted after exposure to acid.

https://doi.org/10.1590/1807-3107bor-2025.vol39.016

12.

Espiritualidade/Religiosidade e Adesão ao Tratamento em Indivíduos Hipertensos
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Camargo, Yanne da Silva

; Ferreira, Aliny Serafim Borges

; Scalia, Luana Araújo Macedo

; Magnabosco, Patrícia

; Bragato, Aline Guarato da Cunha

; Raponi, Maria Beatriz Guimarães

; Dinamarco, Nelson

; Figueiredo, Valéria Nasser

Arquivos Brasileiros de Cardiologia

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2025, Volume 122 N. 2 elocation e20240558

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Fundamento A adesão ao tratamento medicamentoso e não medicamentoso para hipertensão tem um impacto socioeconômico importante, além de reduzir o risco de eventos cardiovasculares, morbidade e mortalidade. Sabe-se que a espiritualidade e a religiosidade podem ser incorporadas no manejo da hipertensão. Objetivo Analisar possíveis fatores associados com a adesão ao tratamento em pacientes hipertensos e o papel da espiritualidade/religiosidade nesse contexto. Métodos Estudo observacional, transversal, quantitativo, conduzido com 237 indivíduos hipertensos avaliados em um grande hospital de ensino no Brasil. Dados sociodemográficos, clínicos e de estilo de vida foram coletados, além das medidas antropométricas e realização do exame físico. Para determinar a adesão ao tratamento medicamentoso e não medicamentoso para hipertensão, utilizou-se o questionário QATSAH (Questionnaire of Adherence to the Treatment of Hypertension) e, para avaliar o nível de espiritualidade/religiosidade, foram aplicados o Inventário de Religiosidade de Duke e a Medida Multidimensional Breve de Religiosidade/Espiritualidade. Resultados Níveis mais altos de adesão ao tratamento foram observados nos indivíduos com idade ≥65, fisicamente ativos, e que não consumiam bebida alcoólica (p<0,05). Em relação à religiosidade e à espiritualidade, a religiosidade intrínseca [β = 0,24, IC95% (0,22; 1,13), p = 0,004), valores e crenças (β = -0,18, IC95% [-1,58; -0,20]; p = 0,012), e perdão (β = 0,16; IC95% [0,13, 1,19], p = 0,015) foram preditores estatisticamente significativos de adesão ao tratamento. Religiosidade organizacional, religiosidade não organizacional, e experiências espirituais diárias não foram significativos. Conclusão Religiosidade intrínseca mais alta, escores mais baixos de “valores e crenças” e escores mais altos de “perdão” aumentam o nível de adesão medicamentosa e não medicamentosa em indivíduos hipertensos.

Abstract Background Adherence to drug and non-drug treatment for hypertension has a major socioeconomic impact, in addition to reducing the risk of cardiovascular events and morbidity and mortality. It is known that spirituality and religiosity can be incorporated into coping and managing hypertension. Objective To analyze possible factors associated with adherence to treatment in hypertensive patients and the role of spirituality/religiosity in this context. Methods Observational, cross-sectional, quantitative study, carried out with 237 hypertensive individuals monitored in a large Brazilian teaching hospital. Sociodemographic, clinical and lifestyle data were collected, in addition to measuring anthropometric data and performing a physical examination. To determine adherence to drug and non-drug treatment for hypertension, the QATSAH instrument was used and, to assess the level of spirituality/religiosity, the Duke Religion Index and the Brief Multidimensional Measure of Religiousness/Spirituality were applied. Results Higher levels of adherence to treatment were observed when aged ≥65 years, physically active, and who did not consume alcohol (p<0.05). Regarding religiosity and spirituality, intrinsic religiosity (β = 0.24, 95%CI [0.22, 1.13], p = 0.004), values and beliefs (β = -0.18, 95%CI [-1.58, -0.20], p = 0.012), and forgiveness (β = 0.16, 95%CI [0.13, 1.19], p = 0.015) were statistically significant predictors of treatment adherence. Organizational religiosity, non-organizational religiosity, and daily spiritual experiences were not significant. Conclusion Greater intrinsic religiosity, lower scores in Values and Beliefs and higher scores in Forgiveness increase the level of medication and non-medication adherence in hypertensive individuals.

https://doi.org/10.36660/abc.20240558

13.

Knowledge and Prevalence of Dental Trauma among Amateur Soccer Players in a Brazilian Subpopulation: A Cross-Sectional Study
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Matos, Felipe de Souza

; Ferreira, André de Lima

; Ribeiro, Ana Beatriz Bomfîm Gomes

; Bezerra, Vinicius Grangeiro Leite

; Silva, Douglas Teixeira da

; Oliveira, Millena Barroso

; Paranhos, Luiz Renato

Pesquisa Brasileira em Odontopediatria e Clínica Integrada

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2025, Volume 25 elocation e240024

Abstract: En | Text: En | PDF: En

ABSTRACT Objective: To investigate the knowledge and prevalence of dental trauma among amateur soccer players in a Brazilian subpopulation. Material and Methods: The players responded to a 20-item questionnaire on personal characteristics and the prevalence, education, and management of dental injuries between June and August 2023. Five questions with a five-point scoring system evaluated participant knowledge about managing coronal fractures and avulsion. The Mann-Whitney U-test and the Kruskal-Wallis test (p<0.05) compared the subcategories of personal characteristics and education on dental trauma management. Results: Two hundred forty-four (244) amateur soccer players participated in the study, with 55 (22.55%) reporting experiences of traumatic dental injury during games and a higher frequency of coronal fractures. The median score for correctly managing coronal fractures and avulsion was 2.0 points. Athletes with health education/occupation showed a higher median value (3.0 points). Only 9.43% of participants use or have used a mouthguard during sports practice. The study identified a 22.55% prevalence of dental trauma among amateur soccer players. Conclusion: The knowledge of athletes about managing coronal fractures and avulsion is insufficient and requires improvement.

https://doi.org/10.1590/pboci.2025.035

14.

Prospective study of leptospirosis and brucellosis in dogsfrom a public shelter in the municipality of Lavras, Minas Gerais State, Brazil
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Costa, Anna Cecília Trolesi Reis Borges

; Ferreira, Amanda Carvalho Rosado

; Costa, Dirceia Aparecida Custódio

; Colocho, Raisa Abreu Bragança e

; Lopes, Josyane

; Souza, Kelly Cristina de

; Alvez, Susana Mantuani Reis

; Pinho, Gabrielle Zink de

; Silva, Yasmim Domingos da

; Brito, Gustavo Ferreira de

; Ferreira, Blenda Araujo Martins

; Oliveira, Erika Aparecida

; Chaves, Marília Gabriela Dias

; Melo, Sérgio Novais de

; Souza, Ana Beatriz Barion

; Pereira, Carine Rodrigues

; Hirsch, Christian

; Rodrigues, Rogério Oliveira

; Heinemann, Marcos Bryan

; Lage, Andrey Pereira

; Sanchez, Javier Dorneles, Elaine Maria Seles

Ciência Rural

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2025, Volume 55 N. 7 elocation e20230552

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO: O objetivo deste estudo foi avaliar a prevalência e a incidência da leptospirose e da brucelose canina em um abrigo chamado Parque Francisco de Assis, em Lavras, Minas Gerais, Brasil, bem como os fatores de risco potencialmente associados a ambas as doenças. Amostras de sangue, urina e soro de todos os animais foram coletadas em 2019 (n = 329) e 2020 (n = 325 dogs). DNA de Leptospira spp. (urina) e Brucella spp. (urina e sangue) foram pesquisados por PCR, enquanto o teste de microaglutinação (MAT) e o ensaio de imunodifusão em gel de ágar (AGID) foram realizados para identificar anticorpos anti-Leptospira spp. e anti-Brucella spp., respectivamente. Os resultados não mostraram cães positivos na PCR para Leptospira spp.; entretanto, foi encontrada uma soroincidência de 9,24% considerando os resultados do MAT, sendo Canicola e Autumnalis os sorogrupos mais comuns. A incidência de Brucella spp. nos animais PCR positivos nos seis meses foi de 5,62% na urina e 11,23% nas amostras de sangue, enquanto a AGID apresentou soroincidência de 11,74% no período. No geral, nossos resultados demonstraram a circulação de Leptospira spp. e Brucella spp. entre os cães do Parque Francisco de Assis, Lavras, Minas Gerais, Brasil, sendo o aumento de peso (1.10, 95%CI 1.00-1.21) e a neutropenia (3.29, 95%CI 1.60-6.77) os fatores de risco associados à ocorrência de leptospirose e brucelose, respectivamente. Portanto, foi identificada brucelose nos cães do Parque Francisco de Assis, e a presença de anticorpos contra Leptospira spp. sugerindo contato dos cães com o patógeno, o que representa assim um risco para os demais animais e para os seres humanos em contato próximo com os cães positivos.

ABSTRACT: The aim of this study was to assess the prevalence and incidence of canine leptospirosis and brucellosis in Parque Francisco de Assis, a shelter in Lavras, Minas Gerais State, Brazil, as well as the risk factors potentially associated with both diseases. Samples of blood, urine, and sera from all animals were collected in 2019 (n = 329) and 2020 (n = 325 dogs). DNA of Leptospira spp. (urine) and Brucella spp. (urine and blood) were searched by PCR, whereas microagglutination test (MAT) and agar gel immunodiffusion assay (AGID) were performed to identify antibodies anti-Leptospira spp. and anti-rough Brucella spp., respectively. The results showed no positive dogs in PCR for Leptospira spp.; however, a seroincidence of 9.24% was found considering MAT results, with Canicola and Autumnalis being the most common serogroups. The incidence of Brucella spp. PCR-positive animals in the 6 months was 5.62% in the urine and 11.23% in the blood samples, while AGID showed a seroincidence of 11.74% in the period. Overall, our results demonstrated the circulation of Leptospira spp. and Brucella spp. among the dogs from Parque Francisco de Assis, Lavras, Minas Gerais, Brazil, being the weight increase (1.10, 95%CI 1.00-1.21) and neutropenia (3.29, 95%CI 1.60-6.77), the risk factors associated with the occurrence of leptospirosis and brucellosis, respectively. Therefore, brucellosis was identified in the dogs of Parque Francisco de Assis, and the presence of antibodies against Leptospira spp. suggesting contact of the dogs with the pathogen, which represent a risk for the other animals and to the humans in close contact with the positive dogs.

https://doi.org/10.1590/0103-8478cr20230552

15.

Emergence Rate and N Metabolism Assessment of Herbaceous Cotton (Gossypium hirsutum l.r. latifolium Hutch) in Soil with High Boron Concentrations
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Souza, Roberta Possas de

; Araujo, Maycon Anderson de

; Ferreira, Tássia Caroline

; Santos, Beatriz Silvério dos

; Carvalho, Isabella Fiorini de

; Cozin, Bruno Bonadio

; Camargos, Liliane Santos de

Brazilian Archives of Biology and Technology

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2025, Volume 68 elocation e25240280

Abstract: En | Text: En | PDF: En

Abstract Plants need boron (B) in low concentrations to carry out structural and metabolic functions. However, excess B in the soil can cause problems in plant emergence and development. This study aimed to evaluate the emergence responses and production of nitrogen compounds of herbaceous cotton (Gossypium hirsutum L.R. latifolium Hutch) germinated in soil with high concentrations of B. The experiment was carried out in a greenhouse, under a completely randomized design, using different concentrations of B, at concentrations 0.5 (control), 30, 60, and 120 mg B dm-3 soil. Plants were cultivated for 15 days, for evaluation of emergence parameters, and reserves partition and allocation. There was a significant effect of the B application on the emergence velocity index (EVI), emergence percentage, and shoot length. We observed a decrease in the shoot dry mass production and a significant increase in photosynthetic pigments; the concentrations of total soluble amino acids in stems, leaves, and cotyledons, as well as the concentrations of total soluble protein in cotyledons and the concentrations of starch present in all organs, were affected. G. hirsutum showed signs of phytotoxicity in the treatment of 120 mg B dm-3, for all evaluated parameters.

https://doi.org/10.1590/1678-4324-2025240280

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