Scientific press releases are reaching the public directly through press reproduction or institutional dissemination. Science News Agencies (SNAs) mediate this process, distributing texts to thousands of journalists while also "leaking" them on their websites and social media. This comparative case study examines four SNAs — BORI, SMC UK, AlphaGalileo, and EurekAlert! — regarding their role in circulating public scientific information. Through literature review and principles such as openness and inclusion in science, we converted scholars' concerns into a preliminary index potentially capable of assessing SNAs' public suitability. The SNAPI (Science News Agencies Public Index) suggests a shift from purely public relations content towards serving the public interest, highlighting areas needing attention in SNAs' social function, to be refined in future research. Clear guidelines, links to open scientific articles, and explicit notices on press releases’ purposes are simple yet effective ways to address issues concerning science public relations' pervasiveness in the public sphere.

Resumo Introdução: A promoção da literacia em saúde é crucial para que os utentes possam tomar decisões adequadas em matéria de saúde, promovendo uma utilização mais eficiente dos recursos e contribuindo para a sua sustentabilidade. Objetivos: Promover a literacia em saúde entre os utentes de seis Unidades de Saúde Familiar (USF) no Norte de Portugal acerca da organização e estrutura dos cuidados de saúde primários (CSP) e a especialidade médica de medicina geral e familiar (MGF). Métodos: Estudo observacional, prospetivo, do tipo coorte. Foram aplicados questionários em formato Google® Docs a utentes com 18 ou mais anos, que preenchiam os critérios de inclusão, antes e após um mês da intervenção. A intervenção consistiu na visualização de um vídeo formativo preparado pelos autores acerca da organização e os recursos dos CSP e a especialidade de MGF. Resultados: O questionário pré-intervenção foi preenchido por 274 utentes, 165 visualizaram o vídeo educativo e 113 preencheram o questionário pós-intervenção. Apenas 88 utilizadores participaram em todas as fases do projeto e foram considerados elegíveis para a interpretação dos resultados. Após a intervenção verificou-se uma melhoria estatisticamente significativa na classificação geral obtida no questionário, com um aumento na percentagem de respostas corretas de 66,7% para 72,7% (p=0,004; IC 95%). Verificou-se também um aumento na taxa de respostas corretas em quase todas as questões aplicadas. Discussão e Conclusão: A literacia em saúde ajuda os cidadãos a tomar melhores decisões em relação à sua saúde, com um consequente impacto económico e social. Este projeto culminou na criação de uma ferramenta multimédia capaz de melhorar os conhecimentos dos utentes portugueses acerca dos CSP, passível de ser replicada noutros locais do País.

Abstract Introduction: Promoting health literacy is essential for patients to make informed healthcare decisions, ensuring more efficient resource utilization and contributing to long-term sustainability. Objectives: Enhance health literacy among patients in six health units in Northern Portugal, focusing on the organization and structure of primary healthcare services (PHC) and the medical specialty of general practice/family medicine (GPFM). Methods: An observational, prospective cohort study was conducted. Questionnaires in Google® Docs format were administered to patients aged 18 and older who met the inclusion criteria, both before and one month after the intervention. The intervention involved watching an educational video created by the authors about PHC's organization, resources, and GPFM specialty. Results: The pre-intervention questionnaire received responses from 274 patients, with 165 of them viewing the educational video and 113 completing the post-intervention questionnaire. Eighty-eight participants engaged in all phases of the project and were considered eligible for result analysis. After the intervention, there was a statistically significant improvement in the overall questionnaire score, with the percentage of correct answers increasing from 66.7% to 72.7% (p=0.004; CI 95%). Correct answer rates also improved across most of the questions. Discussion and Conclusion: Health literacy empowers individuals to make informed health choices, resulting in economic and social benefits. This project led to the creation of a multimedia tool that can enhance the understanding of Portuguese patients regarding PHC, with potential for replication in other regions of the country.

ABSTRACT Due to the development of complications and the biocompatibility and scarcity of transplant donor tissues, artificial corneas, which can be used for the rehabilitation of optical functions, have been developed. The current study aimed to analyze the visual rehabilitation effects of the Boston type I keratoprosthesis, Boston type II keratoprosthesis, Aurolab keratoprosthesis, osteo-odonto-keratoprosthesis, and tibial bone keratoprosthesis. Results showed that the Boston type I keratoprosthesis was the most effective for visual rehabilitation in patients with moist ocular surfaces. The Aurolab keratoprosthesis had a lower efficacy for visual rehabilitation. Nevertheless, it is still a viable option for individuals in economically restricted countries. In patients with dry eyes, the Boston type II keratoprosthesis was associated with the best visual rehabilitation. However, the final visual acuity of patients who received osteo-odonto-keratoprosthesis and tibial bone keratoprosthesis implantation was not evaluated as the necessary information was not available. tissues corneas functions developed osteoodontokeratoprosthesis, osteoodontokeratoprosthesis osteo odonto surfaces Nevertheless countries eyes However available

RESUMO Em decorrência de complicações, da biocompatibilidade e da escassez de tecido doador para transplantes de córnea natural, foram elaboradas córneas artificiais que são potenciais para reabilitar funções ópticas. Nessa perspectiva, objetivou-se a análise da eficácia da reabilitação visual entre os implantes: Boston tipo I, Boston tipo II, Aurolab, osteo-odonto-ceratoprótese e ceratoprótese de Osso Tibial. De modo geral, a princípio observou-se uma tendência de melhoria da Best-corrected visual acuity em todos os tipos de lentes, mas considerável queda durante acompanhamento a longo prazo. O dispositivo com melhor reabilitação visual em pacientes com superfícies oculares úmidas é a Boston tipo I, seguida pela Aurolab, que é economicamente viável em países emergentes. Ao considerar pacientes com olhos secos, o implante de Boston tipo II apresenta maior reabilitação visual. Por fim, em virtude de não apresentarem dados equiparáveis, as lentes osteo-odonto-ceratoprótese e de osso tibial não puderam ser analisadas. complicações natural ópticas perspectiva objetivouse objetivou se implantes I Aurolab osteoodontoceratoprótese osteo odonto Tibial geral observouse observou Bestcorrected Best corrected prazo emergentes secos fim equiparáveis analisadas

ABSTRACT A survey of trametoid fungi species from Parque Estadual das Fontes do Ipiranga (PEFI), located in the city of São Paulo, SP, Brazil (23o38’00”S-23o40’18”S, 46o36’48”W-46o38’08”W), was carried out. Fifteen species belonging to six genera were identified from the analysis of macro and micro morphology in which the dimensions of the basidiomata, texture, color, as well as, the size of hyphae, basidia, basidiospores and cystidia, were evaluated. The species are distributed in: Cerrena Gray (uma sp.), Funalia Pat. (1 sp.), Hexagonia Fr. (duas spp.), Lenzites Fr. (uma sp.), Podofomes Pouzar (duas spp.), Pycnoporus T. Karst. (uma sp.), and Trametes Fr. (sete spp). Trametes lactinea (Berk.) Sacc. was found as a new record for the State of São Paulo; Podofomes mollis (Sommerf.) Gorjón, P. stereoides (Fr.) Gorjón, Trametes cubensis (Mont.) Sacc., T. decipiens Bres. and T. neovillosa Fernandes & Gugliotta are reported for the first time from the locality. Identification key, descriptions and comments of the taxa studied are provided herewith. PEFI, PEFI , (PEFI) Paulo SP 23o3800S23o4018S, 23o3800S23o4018S oSoS 23o38 00 S 23o40 18 S, o (23o38’00”S-23o40’18”S 46o3648W46o3808W, 46o3648W46o3808W oWoW 46o36 48 W 46o38 08 46o36’48”W-46o38’08”W) out basidiomata texture color hyphae basidia cystidia evaluated uma sp., sp sp. sp.) Pat 1 ( Fr duas spp., spp spp. spp.) T Karst sete . spp) Berk. Berk (Berk. Sacc Sommerf. Sommerf (Sommerf. Gorjón P (Fr. Mont. Mont (Mont. Bres locality key herewith (PEFI 23o3 0 23o4 46o3 4 46o36’48”W-46o38’08”W (Berk (Sommerf (Fr (Mont 23o 46o

RESUMO Foi realizado o levantamento das espécies de fungos trametoides do Parque Estadual das Fontes do Ipiranga (PEFI), localizado no município de São Paulo, São Paulo, Brasil (23o38’00”S-23o40’18”S, 46o36’48”W-46o38’08”W). Quinze espécies pertencentes a seis gêneros foram identificadas a partir da análise da macro e micromorfologia, em que foram avaliadas as dimensões dos basidiomas, textura, cor, assim como o tamanho das hifas, basídios, basidiósporos e cistídios. As espécies estão distribuídas em: Cerrena Gray (one sp.), Funalia Pat. (one sp.), Hexagonia Fr. (two spp.), Lenzites Fr. (one sp.), Podofomes Pouzar (two spp.), Pycnoporus T. Karst. (one sp.), and Trametes Fr. (seven spp). Trametes lactinea (Berk.) Sacc. foi encontrado como novo registro para o Estado de São Paulo; Podofomes mollis (Sommerf.) Gorjón, P. stereoides (Fr.) Gorjón, Trametes cubensis (Mont.) Sacc., T. decipiens Bres. e T. neovillosa Fernandes & Gugliotta são relatados pela primeira vez para a localidade. Chave de identificação, descrições e comentários dos táxons estudados são fornecidos a seguir. PEFI, PEFI , (PEFI) Paulo 23o3800S23o4018S, 23o3800S23o4018S oSoS 23o38 00 S 23o40 18 S, (23o38’00”S-23o40’18”S 46o3648W46o3808W. 46o3648W46o3808W oWoW 46o36 48 W 46o38 08 . 46o36’48”W-46o38’08”W) micromorfologia basidiomas textura cor hifas basídios cistídios one sp., sp sp. sp.) Pat Fr two spp., spp spp. spp.) T Karst seven spp) Berk. Berk (Berk. Sacc Sommerf. Sommerf (Sommerf. Gorjón P (Fr. Mont. Mont (Mont. Bres localidade identificação seguir (PEFI 23o3 0 23o4 1 46o3 4 46o36’48”W-46o38’08”W (Berk (Sommerf (Fr (Mont 23o 46o

ABSTRACT This case study examines the clinical course of a Bothrops snakebite poisoning that occurred in Jarinu, São Paulo, Brazil, in 2021. The patient required a fasciotomy in the upper limb due to acute compartment syndrome, followed by a second surgical procedure involving dermo-epidermal grafting. In the late postoperative period, the patient experienced retraction, leading to a subsequent surgical intervention to correct the retraction in the left upper limb. The severity of the snakebite accident, the effects of venom on tissues, complications, acute compartment syndrome, as well as the indications and techniques for decompressive fasciotomy, are discussed based on the available literature. Jarinu Paulo Brazil 2021 syndrome dermoepidermal dermo epidermal grafting period accident tissues complications literature 202 20 2

RESUMO Este relato de caso aborda o curso clínico de um envenenamento botrópico ocorrido no município de Jarinu, SP, no ano de 2021. O paciente necessitou de fasciotomia em membro superior após síndrome compartimental aguda com enxertia dermoepidérmica em um segundo momento cirúrgico. No pós-operatório tardio, o paciente evoluiu com retração, necessitando de reabordagem cirúrgica com correção de retração de membro superior esquerdo. Discute-se a gravidade do acidente ofídico, efeitos do veneno nos tecidos, complicações, síndrome compartimental aguda, indicação e técnica da fasciotomia descompressiva com base na literatura. Jarinu SP 2021 cirúrgico pósoperatório pós operatório tardio esquerdo Discutese Discute se ofídico tecidos complicações literatura 202 20 2

Abstract A male of Pteronura brasiliensis (Carnivora: Mustelidae) was found dead on the banks of the Rio Negro, in the Pantanal wetlands of Mato Grosso do Sul state, Aquidauana municipality. Two ticks found attached to its skin were morphologically identified as a second-instar nymph of Ornithodoros rostratus (Argasidae) and a male of Amblyomma sculptum (Ixodidae). In order to complement the morphological identification, these tick specimens were subjected to DNA extraction, and tested using PCR assays to confirm the molecular identity the specimens. Also, the tick DNA samples were tested and were negative in the PCR assays for all the pathogens tested. We also examined 30 batches, consisting of 174 individuals of O. rostratus deposited in the Acari Collection of the Butantan Institute, and we found material from four Brazilian states, including one batch containing 2 males and 2 females from Aquidauana, of Mato Grosso do Sul state, collected from the soil. This was therefore the first record of O. rostratus parasitizing P. brasiliensis and the first locality record (Aquidauana). Likewise, A. sculptum is commonly found in the Pantanal and is reported here for the second time parasitizing the giant otter, which is a host little studied regarding the ectoparasites. Carnivora (Carnivora Mustelidae Negro state municipality secondinstar instar Argasidae (Argasidae Ixodidae. Ixodidae . (Ixodidae) identification extraction Also 3 batches 17 O Institute states soil P Aquidauana. (Aquidauana) Likewise otter ectoparasites (Ixodidae 1 (Aquidauana

Resumo Um macho de Pteronura brasiliensis (Carnivora: Mustelidae) foi encontrado morto às margens do Rio Negro, no Pantanal do estado de Mato Grosso do Sul, município de Aquidauana. Dois carrapatos encontrados aderidos à sua pele foram identificados, morfologicamente, como uma ninfa de segundo ínstar de Ornithodoros rostratus (Argasidae) e um macho de Amblyomma sculptum (Ixodidae). Para complementar a identificação morfológica, esses espécimes de carrapatos foram submetidos à extração de DNA e testados por meio de ensaios de PCR, para confirmar a identidade molecular dos espécimes. Além disso, os extraídos dos carrapatos foram testados e revelaram-se negativos nos ensaios de PCR para todos os patógenos testados. Também foram examinados 30 lotes, compostos por 174 indivíduos de O. rostratus, depositados na Coleção Acari do Instituto Butantan, e encontramos material de quatro estados brasileiros, incluindo-se um lote contendo 2 machos e 2 fêmeas de Aquidauana, estado de Mato Grosso do Sul (MS), coletado do solo. Este foi, portanto, o primeiro registro de O. rostratus parasitando P. brasiliensis e o primeiro registro de localidade (Aquidauana). Da mesma forma, A. sculptum é comumente encontrado no Pantanal e relatado aqui, pela segunda vez, parasitando a ariranha, hospedeiro pouco estudado em relação a ectoparasitas. Carnivora (Carnivora Mustelidae Negro Aquidauana identificados morfologicamente Argasidae (Argasidae Ixodidae. Ixodidae . (Ixodidae) morfológica disso revelaramse revelaram se 3 lotes 17 O Butantan brasileiros incluindose incluindo MS, MS , (MS) solo portanto P (Aquidauana) forma A aqui vez ariranha ectoparasitas (Ixodidae 1 (MS (Aquidauana

Abstract Background Infectious meningoencephalitis is a potentially fatal clinical condition that causes inflammation of the central nervous system secondary to the installation of different microorganisms. The FilmArray meningitis/encephalitis panel allows the simultaneous detection of 14 pathogens with results in about one hour. Objective This study is based on retrospectively evaluating the implementation of the FilmArray meningitis/encephalitis panel in a hospital environment, highlighting the general results and, especially, analyzing the consistency of the test results against the clinical and laboratory conditions of the patients. Methods Data were collected through the results reported by the BioFire FilmArray system software from the meningitis/encephalitis panel. The correlated laboratory tests used in our analysis, when available, included biochemical, cytological, direct and indirect microbiological tests. Results In the analyzed period, there were 496 samples with released results. Of the total of 496 samples analyzed, 88 (17.75%) were considered positive, and 90 pathogens were detected, and in 2 of these (2.27%) there was co-detection of pathogens. Viruses were the agents most frequently found within the total number of pathogens detected. Of the 496 proven samples, 20 (4.03%) were repeated, 5 of which were repeated due to invalid results, 6 due to the detection of multiple pathogens and 9 due to disagreement between the panel results and the other laboratory tests and/or divergence of the clinical-epidemiological picture. Of these 20 repeated samples, only 4 of them (20%) maintained the original result after repeating the test, with 16 (80%) being non-reproducible. The main factor related to the disagreement of these 16 samples during retesting was the detection of bacterial agents without any relationship with other laboratory tests or with the patients' clinical condition. Conclusion In our study, simply reproducing tests with atypical results from the FilmArray meningitis/encephalitis panel proved, in most cases, effective and sufficient for interpreting these results. microorganisms meningitisencephalitis meningitis encephalitis 1 hour environment especially patients analysis available biochemical cytological period 49 8 17.75% 1775 17 75 (17.75% positive detected 2.27% 227 27 (2.27% codetection co 4.03% 403 03 (4.03% andor clinicalepidemiological epidemiological picture 20% (20% 80% 80 (80% nonreproducible. nonreproducible non reproducible. reproducible non-reproducible proved cases 17.75 177 7 (17.75 2.27 22 (2.27 4.03 40 0 (4.03 (20 (80 17.7 (17.7 2.2 (2.2 4.0 (4.0 (2 (8 17. (17. 2. (2. 4. (4. ( (17 (4 (1

Resumo Antecedentes A meningoencefalite infecciosa é uma condição clínica potencialmente fatal que causa inflamação do sistema nervoso central secundária à instalação de diversos microrganismos. O painel de meningite/encefalite FilmArray permite a detecção simultânea de 14 patógenos, com resultados em cerca de uma hora. Objetivo Este estudo baseia-se em avaliar retrospectivamente a implementação do painel de meningite/encefalite FilmArray em ambiente hospitalar, destacando os resultados gerais e, principalmente, analisando a consistência dos resultados do teste frente às condições clínicas e laboratoriais dos pacientes. Métodos Os dados foram coletados por meio dos resultados relatados pelo software do sistema BioFire FilmArray do painel de meningite/encefalite. Os exames laboratoriais correlacionados utilizados em nossa análise, quando disponíveis, incluíram exames bioquímicos, citológicos, microbiológicos diretos e indiretos. Resultados No período analisado, foram 496 amostras com resultados divulgados. Do total de 496 amostras analisadas, 88 (17,75%) foram consideradas positivas e 90 patógenos foram detectados, sendo que em duas destas (2,27%) houve codetecção de patógenos. Os vírus foram os agentes mais frequentemente encontrados dentro do total de patógenos detectados. Das 496 amostras analisadas, 20 (4,03%) foram repetidas, sendo 5 repetidas por resultado inválido, 6 pela detecção de múltiplos patógenos e 9 por discordância dos resultados do painel com os demais exames laboratoriais e/ou divergência do quadro clínico-epidemiológico. Destas 20 amostras repetidas, apenas 4 delas (20%) mantiveram o resultado original após a repetição do teste, sendo 16 (80%) não reprodutíveis. O principal fator relacionado à discordância destas 16 amostras na retestagem foi a detecção de agentes bacterianos sem qualquer relação com os demais exames laboratoriais ou com o quadro clínico dos pacientes. Conclusão Em nosso estudo, a simples repetição dos testes com resultados atípicos do painel de meningite/encefalite FilmArray mostrou-se, na maior dos casos, efetiva e suficiente para a interpretação destes achados. microrganismos meningiteencefalite meningite encefalite 1 hora baseiase baseia se hospitalar principalmente pacientes análise disponíveis bioquímicos citológicos indiretos analisado 49 divulgados analisadas 8 17,75% 1775 17 75 (17,75% detectados 2,27% 227 2 27 (2,27% 4,03% 403 03 (4,03% inválido eou clínicoepidemiológico. clínicoepidemiológico epidemiológico. epidemiológico clínico-epidemiológico 20% (20% 80% 80 (80% reprodutíveis mostrouse, mostrouse mostrou se, mostrou-se casos achados 17,75 177 7 (17,75 2,27 22 (2,27 4,03 40 0 (4,03 (20 (80 17,7 (17,7 2,2 (2,2 4,0 (4,0 (2 (8 17, (17, 2, (2, 4, (4, ( (17 (4 (1

Abstract Background Chikungunya is a mosquito-borne disease caused by the chikungunya virus (CHIKV) and can lead to neurological complications in severe cases. Objective This study examined neuroimaging patterns in chikungunya cases during two outbreaks in Brazil to identify specific patterns for diagnosis and treatment of neuro-chikungunya. Methods Eight patients with confirmed chikungunya and neurological involvement were included. Clinical examinations and MRI scans were performed, and findings were analyzed by neuroradiologists. Data on age, sex, neurological symptoms, diagnostic tests, MRI findings, and clinical outcomes were recorded. Results Patients showed different neuroimaging patterns. Six patients exhibited a "clock dial pattern" with hyperintense dotted lesions in the spinal cord periphery. One patient had thickening and enhancement of anterior nerve roots. Brain MRI revealed multiple hyperintense lesions in the white matter, particularly in the medulla oblongata, in six patients. One patient had a normal brain MRI. Conclusion The "clock dial pattern" observed in spinal cord MRI may be indicative of chikungunya-related nervous system lesions. Isolated involvement of spinal cord white matter in chikungunya can help differentiate it from other viral infections. Additionally, distinct brainstem involvement in chikungunya-associated encephalitis, particularly in the rostral region, sets it apart from other arboviral infections. Recognizing these neuroimaging patterns can contribute to early diagnosis and appropriate management of neuro-chikungunya. mosquitoborne mosquito borne CHIKV (CHIKV neurochikungunya. neurochikungunya neuro chikungunya. neuro-chikungunya included performed neuroradiologists age sex symptoms tests recorded clock pattern periphery roots oblongata chikungunyarelated related infections Additionally chikungunyaassociated associated encephalitis region

Resumo Antecedentes A chikungunya é uma doença transmitida por mosquitos causada pelo vírus chikungunya (CHIKV) e pode levar a complicações neurológicas em casos graves. Objetivo Este estudo examinou padrões de neuroimagem em casos de chikungunya durante dois surtos no Brasil para identificar padrões específicos para o diagnóstico e tratamento de neurochikungunya. Métodos Oito pacientes com chikungunya confirmada e envolvimento neurológico foram incluídos. Exames clínicos e ressonâncias magnéticas (RM) foram realizados, e os achados foram analisados por neurorradiologistas. Dados sobre idade, sexo, sintomas neurológicos, testes diagnósticos, achados de RM e desfechos clínicos foram registrados. Resultados Os pacientes apresentaram diferentes padrões de neuroimagem. Seis pacientes apresentaram um "padrão de mostrador de relógio" com lesões pontilhadas hiperintensas na periferia da medula espinhal. Um paciente apresentou espessamento e realce das raízes nervosas anteriores. A RM do cérebro revelou múltiplas lesões hiperintensas na substância branca, especialmente no bulbo em seis pacientes. Um paciente apresentou uma RM cerebral normal. Conclusão O "padrão de mostrador de relógio" observado na RM da medula espinhal pode ser indicativo de lesões do sistema nervoso relacionadas à chikungunya. O envolvimento isolado da substância branca da medula espinhal na chikungunya pode ajudar a diferenciá-la de outras infecções virais. Além disso, o envolvimento distinto do tronco cerebral na encefalite associada à chikungunya, especialmente na região rostral, a distingue de outras infecções por arbovírus. O reconhecimento desses padrões de neuroimagem pode contribuir para o diagnóstico precoce e manejo adequado da neurochikungunya. CHIKV (CHIKV graves neurochikungunya incluídos (RM realizados neurorradiologistas idade sexo neurológicos diagnósticos registrados padrão relógio anteriores normal diferenciála diferenciá la virais disso rostral arbovírus

ABSTRACT Objective: To investigate associations/correlations between bone alterations and vitamin D status in children through data mining analyses based on observational studies. Material and Methods: Searches in PubMed, Scopus, Web of Science, and Embase databases were performed to recover studies, published until October 2022, with healthy children, which investigated the vitamin D status, related or not to undesirable bone alterations linked to bone quality (bone mineral density and bone mineral content), fracture or anthropometry. Country, study design, area of expertise (medicine, nutrition, dentistry, others), bone outcome, 25-hydroxyvitamin D data (serum or intake levels), the exams for bone diagnosis, and the results were analyzed in the VantagePointTM software. Results: Of 20,583 studies, 27 were included. The USA (n=9; 33.3%) had the highest number of publications. Cross-sectional (n=11; 40.7%), case-control (n=9; 33.3%), and cohort studies (n=7; 25.9%) contemplated the medicine and nutritional areas without any study in dentistry. Studies about bone quality (n=21; 77.8%), analyzed through dual-energy X-ray absorptiometry (DXA; n=14; 51.8%), with association (n=16; 59.2%) between the low serum levels of 25-hydroxyvitamin D and undesirable bone alterations (n=14; 51.8%) were the most prevalent. Conclusion: Most studies were conducted in the medical area and showed an association between low bone quality and low levels of 25-hydroxyvitamin D, verified through DXA. Objective associationscorrelations associations correlations Methods PubMed Scopus Science 2022 content, content , content) anthropometry Country design medicine, (medicine nutrition dentistry others, others others) outcome 25hydroxyvitamin hydroxyvitamin 25 levels, levels) diagnosis software Results 20583 20 583 20,58 2 included n=9 n9 n 9 (n=9 33.3% 333 33 3 publications Crosssectional Cross sectional n=11 n11 11 (n=11 40.7%, 407 40.7% 40 7 40.7%) casecontrol case control 33.3%, n=7 n7 (n=7 25.9% 259 n=21 n21 21 (n=21 77.8%, 778 77.8% 77 8 77.8%) dualenergy dual energy Xray X ray DXA (DXA n=14 n14 14 51.8%, 518 51.8% 51 n=16 n16 16 (n=16 59.2% 592 59 (n=14 prevalent Conclusion 202 2058 58 20,5 n= (n= 33.3 n=1 n1 1 (n=1 40.7 4 25.9 n=2 n2 (n=2 77.8 51.8 5 59.2 205 20, (n 33. 40. 25. 77. 51. 59.

Abstract Introduction The voice and hearing can be affected to different degrees by aging, which can cause communication difficulties for elderly people. Vocal production requires effective temporal auditory processing at central levels within the nervous system, which can be compromised by the aging process. Objective To analyze the correlation between voice and temporal auditory processing in older adults. Materials and Methods A total of 40 elderly people aged 60 years or older were subdivided into 2 groups according to the presence or absence of vocal symptoms measured by the Voice Symptom Scale. All of the participants were submitted to auditory temporal tests, vocal self-assessment, and acoustic and perceptual auditory analyses of voice. Results Most of the subjects assessed had decreased voice intensity and normal variability in terms of vocal quality. The performance was normal in the Pitch Pattern Sequence test and altered in the Random Gap Detection test. In the Masking Period Pattern test, the detection thresholds for the target signal were increased in the presence of masking in different temporal target signal positions. Only pitch differed between the two groups. There were differences between the genders regarding frequency, shimmer, the overall severity of the alteration, and roughness. There was a correlation regarding temporal resolution ability and the overall severity of the alteration and roughness of the voice. Conclusion There is a central auditory impairment in temporal resolution which is correlated with vocal alterations in the elderly. system process adults 4 6 Scale tests selfassessment, selfassessment self assessment, assessment self-assessment quality positions frequency shimmer

ABSTRACT Backgrounds: Fortunately, much has been studied about COVID-19 in patients with inflammatory bowel diseases (IBD). Evidence suggests that these patients do not appear to be at increased risk of severe COVID-19. However, there are still some uncertainties regarding the clinical manifestations of COVID-19 in patients with immune-mediated diseases. Objective: This study aimed to describe the main symptoms of COVID-19 and their frequency in IBD patients and evaluate the impact of the IBD therapeutic drugs on clinical presentation of COVID-19 and to determine factors associated with COVID-19 in this population. Methods: Adult patients with IBD from three tertiary-care public, teaching hospitals in Ceará, Northeastern Brazil, were evaluated during one scheduled appointment from March to December 2020. Patients with possible or confirmed COVID-19 were compared with patients without COVID-19. Furthermore, incidences of each symptom were evaluated based on the use of IBD therapeutic drugs. Results: A total of 515 patients with IBD were included in the study: 234 with CD, and 281 with UC. Of these, 174 patients (34%) had possible/confirmed COVID-19 of whom 156 (90%) were symptomatic. Main symptoms were fever (65%) and headache (65%); gastrointestinal symptoms occurred in one third of patients and were higher than COVID-19 in general population. The factors associated with having COVID-19 were female gender (OR 1.71, 95%CI: 1.17-2.50); contact at home (OR 5.07, 95%CI: 3.31-7.78) and outside the home (OR 3.14, 95%CI: 2.10-4.71) with a case of COVID-19; work outside of the home (OR 1.87, 95%CI: 1.26-2.78); family history of COVID-19 (OR 2.29, 95%CI 1.58-3.33) use of salicylate (OR 1.71, 95%CI: 1.17-4.28); and asthma (OR 7.10, 95%CI: 1.46-34.57). Conclusion: IBD patients at high risk of COVID-19 infection may need to avoid salicylate therapy but further studies are necessary to confirm this association. Backgrounds Fortunately COVID19 COVID 19 COVID-1 IBD. . (IBD) COVID19. 19. However immunemediated immune mediated Objective population Methods tertiarycare tertiary care public Ceará Brazil 2020 Furthermore Results 51 23 CD 28 UC 17 34% 34 (34% possibleconfirmed 15 90% 90 (90% symptomatic 65% 65 (65% OR 171 1 71 1.71 95CI CI 95 1.172.50 117250 1.17 2.50 2 50 1.17-2.50) 507 5 07 5.07 3.317.78 331778 3.31 7.78 3 31 7 78 3.31-7.78 314 14 3.14 2.104.71 210471 2.10 4.71 10 4 2.10-4.71 187 87 1.87 1.262.78 126278 1.26 2.78 26 1.26-2.78) 229 29 2.29 1.583.33 158333 1.58 3.33 58 33 1.58-3.33 1.174.28 117428 4.28 1.17-4.28) 710 7.10 1.4634.57. 1463457 1.46 34.57 46 57 1.46-34.57) Conclusion association COVID1 COVID- (IBD 202 (34 9 (90 6 (65 1.7 172 1.172.5 11725 117 1.1 250 2.5 1.17-2.50 0 5.0 317 3.317.7 33177 331 3.3 778 7.7 3.31-7.7 3.1 104 2.104.7 21047 210 2.1 471 4.7 2.10-4.7 18 8 1.8 262 1.262.7 12627 126 1.2 278 2.7 1.26-2.78 22 2.2 583 1.583.3 15833 158 1.5 333 1.58-3.3 1.174.2 11742 428 4.2 1.17-4.28 7.1 4634 1.4634.57 146345 146 1.4 3457 34.5 1.46-34.57 20 (3 (9 (6 1. 1.172. 1172 11 25 2. 1.17-2.5 5. 3.317. 3317 3. 77 7. 3.31-7. 2.104. 2104 21 47 4. 2.10-4. 1.262. 1262 12 27 1.26-2.7 1.583. 1583 1.58-3. 1.174. 1174 42 1.17-4.2 463 1.4634.5 14634 345 34. 1.46-34.5 ( 1.172 1.17-2. 3.317 3.31-7 2.104 2.10-4 1.262 1.26-2. 1.583 1.58-3 1.174 1.17-4. 1.4634. 1463 1.46-34. 1.17-2 3.31- 2.10- 1.26-2 1.58- 1.17-4 1.4634 1.46-34 1.17- 1.26- 1.463 1.46-3 1.46-

RESUMO Contexto: Felizmente, muito se tem estudado sobre a COVID-19 em pacientes com doenças inflamatórias intestinais (DII). As evidências sugerem que esses pacientes não parecem ter risco aumentado de COVID-19 grave. Mas ainda se tem algumas incertezas com relação às manifestações clínicas da COVID-19 em portadores de doenças imunomediadas. Objetivo: Este estudo teve como objetivo descrever os principais sintomas da COVID-19 e sua frequência em pacientes com DII e avaliar o impacto dos medicamentos utilizados no tratamento das DII na apresentação clínica da COVID-19. Métodos: Pacientes adultos com DII de três hospitais públicos terciários de ensino do Ceará, Nordeste do Brasil, foram avaliados em consulta ambulatorial no período de março a dezembro de 2020. Pacientes com COVID-19 possível ou confirmada foram comparados com pacientes sem COVID-19. Além disso, as incidências de cada sintoma foram avaliadas com base no uso de medicamentos utilizados para tratamento da DII. Resultados: Foram incluídos no estudo 515 pacientes com DII: 234 com DC e 281 com RCU. Destes, 174 pacientes (34%) tinham COVID-19 possível/confirmado, dos quais 156 (90%) eram sintomáticos. Os principais sintomas foram febre (65%) e dor de cabeça (65%); sintomas gastrointestinais ocorreram em um terço dos pacientes, sendo mais frequentes do que na população geral com COVID-19. Os fatores associados a ter COVID-19 foram sexo feminino (OR 1,71, IC95%: 1,17-2,50); ter contato com caso de COVID-19, tanto intradomiciliar (OR 5,07; IC95%: 3,31-7,78) como fora do domicílio (OR 3,14; IC95%: 2,10-4,71); trabalhar fora de casa (OR 1,87; IC95%: 1,26-2,78); história familiar de COVID-19 (OR 2,29, IC95% 1,58-3,33), uso de salicilato (OR 1,71, IC95%: 1,17-4,28) e asma (OR 7,10; IC95%: 1,46-34,57). Conclusão: Pacientes com DII com alto risco de infecção por COVID-19 podem precisar evitar a terapia com salicilatos, mas mais estudos são necessários para confirmar esta associação. Contexto Felizmente COVID19 COVID 19 COVID-1 . (DII) grave imunomediadas Objetivo COVID19. 19. Métodos Ceará Brasil 2020 disso Resultados 51 23 28 RCU Destes 17 34% 34 (34% possívelconfirmado confirmado possível/confirmado 15 90% 90 (90% sintomáticos 65% 65 (65% OR 171 1 71 1,71 IC95 IC 1,172,50 117250 1,17 2,50 2 50 1,17-2,50) COVID19, 19, 5,07 507 5 07 3,317,78 331778 3,31 7,78 3 31 7 78 3,31-7,78 3,14 314 14 2,104,71 210471 2,10 4,71 10 4 2,10-4,71) 1,87 187 87 1,262,78 126278 1,26 2,78 26 1,26-2,78) 229 29 2,29 1,583,33, 158333 1,58 3,33 , 58 33 1,58-3,33) 1,174,28 117428 4,28 1,17-4,28 7,10 710 1,4634,57. 1463457 1,46 34,57 46 57 1,46-34,57) Conclusão salicilatos associação COVID1 COVID- (DII 202 (34 9 (90 6 (65 1,7 IC9 172 1,172,5 11725 117 1,1 250 2,5 1,17-2,50 5,0 0 317 3,317,7 33177 331 3,3 778 7,7 3,31-7,7 3,1 104 2,104,7 21047 210 2,1 471 4,7 2,10-4,71 1,8 18 8 262 1,262,7 12627 126 1,2 278 2,7 1,26-2,78 22 2,2 583 1,583,33 15833 158 1,5 333 1,58-3,33 1,174,2 11742 428 4,2 1,17-4,2 7,1 4634 1,4634,57 146345 146 1,4 3457 34,5 1,46-34,57 20 (3 (9 (6 1, 1,172, 1172 11 25 2, 1,17-2,5 5, 3,317, 3317 3, 77 7, 3,31-7, 2,104, 2104 21 47 4, 2,10-4,7 1,262, 1262 12 27 1,26-2,7 1,583,3 1583 1,58-3,3 1,174, 1174 42 1,17-4, 463 1,4634,5 14634 345 34, 1,46-34,5 ( 1,172 1,17-2, 3,317 3,31-7 2,104 2,10-4, 1,262 1,26-2, 1,583, 1,58-3, 1,174 1,17-4 1,4634, 1463 1,46-34, 1,17-2 3,31- 2,10-4 1,26-2 1,583 1,58-3 1,17- 1,4634 1,46-34 2,10- 1,26- 1,58- 1,463 1,46-3 1,46-

ABSTRACT Background: Budd-Chiari syndrome (BCS) results from the obstruction of the hepatic venous flow, usually at the level of the hepatic vein or inferior vena cava. When left untreated, it can progress with several complications, including liver cirrhosis. Transjugular intrahepatic portosystemic shunt (TIPS) appears to be effective in a subgroup of BCS patients. Objective: To perform a systematic review and meta-analysis of TIPS effectiveness in BCS treatment, considering the survival rate, reduction in portosystemic pressure, need for liver transplantation, technical failure, and shunt dysfunction for up to 10 years of follow-up. Methods: We evaluated 17 studies published in PubMed, Science Direct, Web of Science, and SCOPUS databases, which used TIPS as a treatment for BCS, comprising 618 subjects between 18 and 78 years old. We assessed the bias risk by the NOS, NHI, and JBI scales for cohort studies, before-after studies, and case series, respectively. We conducted the meta-analyses by extracting the number of events and the total patients evaluated to perform the proportion meta-analyses using the R software (“meta” package - version 4.9-6). Results: The pooled results (95%CI) showed a 19% (25.9-12.5%) rate of portosystemic pressure reduction, 6% (1-12%) rate for the need for liver transplants despite the use of TIPS, 2% (1-6%) technical failure rate, 30% (18-46%) shunt dysfunction rate, and 88% (81-93%) for the mean frequency of patients alive between 1 and 10 years after the procedure. We stratified survival rate and found an 86% (74-93%) prevalence of living subjects during less than five years, 92% (83-97%) at five years, and a 77% frequency (68-83%) of patients alive ten years after the TIPS placement. Conclusion: TIPS is an effective treatment for BCS, providing a high 10-year frequency of living patients and a significant decrease in portosystemic pressure. The need for liver transplants after TIPS and the technical failure rate is low. Background BuddChiari Budd Chiari (BCS flow cava untreated complications cirrhosis (TIPS Objective metaanalysis meta analysis transplantation followup. followup follow up. follow-up Methods PubMed Direct databases 61 7 old NOS NHI beforeafter before series respectively metaanalyses analyses (“meta 4.96. 496 4.9 6 . 4 9 4.9-6) Results 95%CI 95CI CI 95 (95%CI 19 25.912.5% 259125 25.9 12.5% 25 12 5 (25.9-12.5% 112% 112 12% (1-12% 2 16% 16 (1-6% 30 1846% 1846 46% 46 (18-46% 88 8193% 8193 81 93% 93 (81-93% procedure 86 7493% 7493 74 (74-93% 92 8397% 8397 83 97% 97 (83-97% 77 6883% 6883 68 83% (68-83% placement Conclusion 10year year low 96 4.96 49 4. 4.9-6 912 25.912.5 25912 259 25. 125 12.5 (25.9-12.5 11 (1-12 (1-6 3 184 (18-46 8 819 (81-93 749 (74-93 839 (83-97 688 (68-83 4.9- 91 25.912. 2591 12. (25.9-12. (1-1 (1- (18-4 (81-9 (74-9 (83-9 (68-8 25.912 (25.9-12 (1 (18- (81- (74- (83- (68- 25.91 (25.9-1 ( (18 (81 (74 (83 (68 (25.9- (8 (7 (6 (25.9 (25. (25 (2

RESUMO Contexto: A síndrome de Budd-Chiari (SBC) é resultante da obstrução do fluxo venoso hepático, usualmente no nível da veia hepática ou da veia cava inferior. Quando não tratada, pode evoluir com complicações, incluindo a cirrose hepática. O tratamento com TIPS parece ser eficaz em um subgrupo de pacientes. Objetivo: Realizar uma revisão sistemática e meta-análise da eficácia do TIPS no tratamento da síndrome de Budd-Chiari, considerando sobrevida, redução de pressão portossistêmica, necessidade de transplante hepático, falha técnica e disfunção no shunt em 10 anos de seguimento. Métodos: Foram avaliados 17 estudos publicados nas bases de dados PubMed, Science direct, Web of Science e SCOPUS, que utilizaram TIPS como tratamento da SBC, correspondendo a um total de 618 pacientes, entre 18 e 78 anos. O risco de viés foi avaliado pelas escalas de NOS, NHI e JBI, para estudos de coorte, antes e depois e séries de casos, respectivamente. As meta-análises foram conduzidas, extraindo o número de eventos e o total de pacientes avaliados para realizar as meta-análises de proporções usando o software R, com o pacote “meta” (versão 4.9-6). Resultados: Os resultados agrupados (IC de 95%) foram de 19% (25,9-12,5%) para a taxa de redução da pressão portossistêmica, 6% (1-12%) para a taxa de necessidade de transplantes hepáticos a despeito do uso do TIPS, 2% (1-6%) para a taxa de falha técnica, 30% (18-46%) para a taxa de disfunção do shunt e 88% (81-93%) para a sobrevida entre 1 e 10 anos depois do procedimento. Estratificando essa sobrevida, foi detectada 86% (74-93%) no período menor do que 5 anos, 92% (83-97%) com 5 anos, e 77% (68-83%) de frequência de pacientes vivos 10 anos após a realização do TIPS. Conclusão: O TIPS é um tratamento eficaz para a SBC, proporcionando elevada sobrevida em 10 anos e uma diminuição significativa da pressão portossistêmica. A necessidade de transplantes de fígado após TIPS e a taxa de falha técnica são baixas. Contexto BuddChiari Budd Chiari SBC (SBC hepático inferior tratada complicações Objetivo metaanálise meta análise BuddChiari, Chiari, portossistêmica seguimento Métodos PubMed direct SCOPUS 61 7 NOS JBI coorte casos respectivamente metaanálises análises conduzidas R “meta versão 4.96. 496 4.9 6 . 4 9 4.9-6) Resultados IC 95% 95 19 25,912,5% 259125 25,9 12,5% 25 12 (25,9-12,5% 112% 112 12% (1-12% 2 16% 16 (1-6% 30 1846% 1846 46% 46 (18-46% 88 8193% 8193 81 93% 93 (81-93% procedimento 86 7493% 7493 74 (74-93% 92 8397% 8397 83 97% 97 (83-97% 77 6883% 6883 68 83% (68-83% Conclusão baixas 96 4.96 49 4. 4.9-6 912 25,912,5 25912 259 25, 125 12,5 (25,9-12,5 11 (1-12 (1-6 3 184 (18-46 8 819 (81-93 749 (74-93 839 (83-97 688 (68-83 4.9- 91 25,912, 2591 12, (25,9-12, (1-1 (1- (18-4 (81-9 (74-9 (83-9 (68-8 25,912 (25,9-12 (1 (18- (81- (74- (83- (68- 25,91 (25,9-1 ( (18 (81 (74 (83 (68 (25,9- (8 (7 (6 (25,9 (25, (25 (2

RESUMO: Objetivo: construir e validar o conteúdo de uma Tecnologia Cuidativo-Educacional para mulheres que consomem substâncias psicoativas. Método: pesquisa metodológica conduzida no município de São Paulo, dezembro de 2022 a março de 2023, pelo mapeamento da literatura, elaboração dos temas geradores, escolha da ferramenta base com dinâmica de uso e validação de conteúdo quanto aos aspectos: reflexão, relevância, compreensão e adequação em duas rodadas. Participaram 15 especialistas com índice de concordância estabelecido de 80%. Resultados: 48 cartas foram submetidas à validação. Na primeira rodada, sete cartas não atingiram o índice mínimo. Ao final da segunda rodada, 47 cartas em todas as suas categorias individuais tiveram concordância maior que o estabelecido. Conclusão: os especialistas apontaram a relevância, pertinência dos temas e o potencial para auxiliar os profissionais a intervir de forma mais assertiva ante as necessidades do público-alvo. RESUMO Objetivo CuidativoEducacional Cuidativo Educacional psicoativas Método Paulo 202 2023 literatura geradores aspectos reflexão relevância rodadas 1 80 80% Resultados 4 rodada mínimo Conclusão públicoalvo. públicoalvo público alvo. alvo público-alvo 20 8 2

RESUMEN Objetivo: construir y validar el contenido de una tecnología educativo-asistencial para mujeres consumidoras de sustancias psicoactivas. Método: investigación metodológica realizada en el municipio de São Paulo, de diciembre de 2022 a marzo de 2023, mediante el mapeo de la literatura, la elaboración de los temas generadores, la elección de la herramienta básica con dinámica de uso y la validación del contenido en cuanto a los aspectos: reflexión, pertinencia, comprensión e idoneidad en dos rondas. Participaron quince expertos, con una tasa de acuerdo del 80%. Resultados: Se presentaron 48 cartas para su validación. En la primera ronda, siete cartas no alcanzaron el índice mínimo. Al final de la segunda ronda, 47 cartas en todas sus categorías individuales tenían más acuerdo del establecido. Conclusión: los expertos señalaron la relevancia y pertinencia de los temas y su potencial para ayudar a los profesionales a intervenir de forma más asertiva ante las necesidades de los destinatarios. Objetivo educativoasistencial educativo asistencial psicoactivas Método Paulo 202 2023 literatura generadores aspectos reflexión rondas 80 80% Resultados 4 ronda mínimo establecido Conclusión destinatarios 20 8 2

ABSTRACT Objective: To build and validate the content of a Care-Educational Technology for women who consume psychoactive substances. Method: Methodological research conducted in the municipality of São Paulo, December 2022 to March 2023 by mapping the literature, drawing up the generating themes, choosing the base tool with dynamics of use, and validating the content in terms of aspects: reflection, relevance, understanding, and suitability in two rounds. Fifteen experts took part, with an agreement rate of 80%. Results: 48 letters were submitted for validation. In the first round, seven cards failed to reach the minimum index. At the end of the second round, 47 cards in all their categories had more agreement than the established level. Conclusion: The experts pointed out the relevance and pertinence of the topics and their potential to help professionals intervene more assertively in the face of the target audience’s needs. Objective CareEducational Care Educational substances Method Paulo 202 literature themes use aspects reflection understanding rounds part 80 80% Results 4 validation round index level Conclusion audiences audience s needs 20 8 2

Abstract Objective: To summarize data of clinical trials that used silver diamine fluoride (SDF) to prevent and treat caries lesions and dentinal hypersensitivity. Material and Methods: Six electronic databases were searched in May 2022. The concentration of SDF, type of usage (alone/combined), dentition, anterior/posterior teeth, tooth region, dental tissue, number of the treated surfaces, the intervention environment, participants' age, frequency and duration of SDF application, purpose, and outcome were the extracted variables. The type of study, year of publication, authors, journals, and country were also investigated. Results: From 8860 articles, S3 were selected. Most were randomized (n=38), that applied 38% SDF (n=43), alone (n=44), on multiple surfaces (n=44), only in dentin (n=36), of the crown (n=46) of anterior and posterior (n=36) primary teeth (n=39). The studies were preferably carried out outside the clinic (n=3l), only in children (n=33), with reapplication of SDF (n=30), but did not inform the duration of application (n= 19). SDF was most used to treat (n=46) only caries lesions (n=50). They were published between 2001 and 2022, mainly in the Journal of Dentistry (n=10). China (n=19) and Lo E.GM (n=19) were the countries and authors that published the most, respectively. Conclusion: The silver diamine fluoride 38% alone was most used to treat caries lesions in the dentin of the crown of all primary teeth, preferably applied on multiple surfaces, requiring re application, and outside the clinic. Objective (SDF hypersensitivity Methods 2022 alone/combined, alonecombined alone/combined , combined (alone/combined) dentition anteriorposterior region tissue environment participants age purpose variables study publication journals investigated Results 886 articles S selected n=38, n38 n n=38 38 (n=38) n=43, n43 n=43 43 (n=43) n=44, n44 n=44 44 (n=44) n=36, n36 n=36 36 n=46 n46 46 (n=46 (n=36 n=39. n39 n=39 . 39 (n=39) n=3l, n3l nl n=3l 3l l (n=3l) n=33, n33 n=33 33 (n=33) n=30, n30 n=30 30 (n=30) n= (n 19. 19 19) n=50. n50 n=50 50 (n=50) 200 n=10. n10 n=10 10 (n=10) n=19 n19 (n=19 EGM E GM respectively Conclusion 202 (alone/combined 88 n3 n=3 3 (n=38 n4 n=4 4 (n=43 (n=44 (n=4 (n=3 (n=39 (n=3l (n=33 (n=30 1 n5 n=5 5 (n=50 20 n1 n=1 (n=10 (n=1 8 (n=5 2

Abstract Objective: Dentistry from the Universidade Federal de Alfenas who were enrolled in the seventh period and who took the Integrated Clinic I Discipline (ICID) in the emergency remote learning model (ERLM). Material and Methods: This is a qualitative and descriptive study. The information was collected through questionnaires applied by the Professors during the ICID. Subsequently, the professor evaluated the treatment developed in virtual form by each student regarding its logical sequence and the most appropriate treatment for each case. The results of the answers were transcribed and submitted to lexicographical textual, Descending Hierarchical Classification, and Similitude analysis in the Interface de R pour les Analyses Multidimensionnelles de Textes et de Questionnaires (IRAMUTEQ) program. Results: The students described the online situational treatment planning in five essential steps: adequacy of the oral environment, restorative need, prosthetic need, rehabilitation by prosthesis on the implant, and corrective orthodontic treatment. Conclusion: It was observed that the students who enrolled in ICID presented well-integrated planning during ERLM, despite the COVID-19 pandemic hindering these students' contact between theoretical teaching and the integrated practices in dentistry offered by the educational institution. Objective (ICID ERLM. ERLM . (ERLM) Methods study Subsequently case textual Classification IRAMUTEQ (IRAMUTEQ program Results steps environment need implant Conclusion wellintegrated well COVID19 COVID 19 COVID-1 institution (ERLM COVID1 1 COVID-