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Microplanejamento na vacinação de alta qualidade: potencialidades e barreiras experienciadas por multiplicadores
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Araújo, Ana Catarina de Melo

; Matozinhos, Fernanda Penido

; Nascimento, Luciana Maiara Diogo

; Ferraz, Carla Conceição

; Diniz, Lorena de Castro Pacheco Barros

; Duarte, Elysângela Dittz

; Fernandes, Eder Gatti

Saúde em Debate

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jun 2025, Volume 49 N. 145 elocation e9370

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Embora o Programa Nacional de Imunizações seja uma das mais importantes intervenções de saúde no Brasil, as coberturas vacinais vêm caindo, sendo necessário pensar estratégias para sua retomada. O microplanejamento é uma tecnologia de baixo custo, utilizada em países da América Latina, aplicável a realidades locais, que possibilita a reorganização dos processos de trabalho em imunização, com a participação de diversos atores. Sua implementação foi proposta no Brasil, trazendo consigo a necessidade de modificar os meios materiais e organizacionais a fim de assegurar as Atividades de Vacinação de Alta Qualidade (Avaq). O objetivo deste relato de experiência foi discutir fatores potencializadores e barreiras para a implementação do microplanejamento para as Avaq, na perspectiva de profissionais dos níveis municipal e estadual que participaram das oficinas para a implementação dessa tecnologia. Os resultados apontam que a metodologia e os conteúdos das oficinas foram capazes de mobilizar os atores envolvidos e subsidiar ações de imunização no nível local, onde se concretizam os resultados das estratégias vacinais. No entanto, são barreiras para a implementação do microplanejamento elementos relacionados a recursos humanos, necessidade de aprimoramento de processos para assegurar o desenvolvimento de todas as etapas do microplanejamento e problemas relacionados a logística e insumos.

ABSTRACT Although the National Immunization Program is one of Brazil’s most important health interventions, vaccination coverage has declined, requiring resumption strategies. Microplanning is a low-cost technology adopted in Latin American countries. It applies to local realities, which enab les reorganizing immunization work processes with the participation of several stakeholders. Its implementation has been proposed in Brazil, carrying the need to modify the material and organizational means to ensure High-Quality Vaccination Activities (HQVA). This experience report aimed to discuss enabling factors and barriers to implementing microplanning for HQVA from the perspective of municipal and state-level professionals who participated in the workshops to implement this technology. The results show that the methodology and content of the workshops mobilized the stakeholders involved and supported immunization actions at the local level, where the results of vaccination strategies take shape. However, barriers to implementing microplanning include elements related to human resources, the need to improve processes to ensure the development of all stages of the microplanning, and problems related to logistics and supplies.

https://doi.org/10.1590/2358-289820251459370p

Microplanejamento na vacinação de alta qualidade: potencialidades e barreiras experienciadas por multiplicadores
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Araújo, Ana Catarina de Melo

; Matozinhos, Fernanda Penido

; Nascimento, Luciana Maiara Diogo

; Ferraz, Carla Conceição

; Diniz, Lorena de Castro Pacheco Barros

; Duarte, Elysângela Dittz

; Fernandes, Eder Gatti

Saúde em Debate

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jun 2025, Volume 49 N. 145 elocation e9370

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

https://doi.org/10.1590/2358-289820251459370p

Desenvolvimento de protótipo de instrumento para aferir autonomia culinária de mulheres
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Maldonado, Luciana

; Oliveira, Mariana Fernandes Brito de

; Castro, Inês Rugani Ribeiro de

Cadernos de Saúde Pública

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2025, Volume 41 N. 2 elocation e00078924

Abstract: Es En Pt | Text: Es En Pt | PDF: Es | PDF: En | PDF: Pt

Este estudio tuvo como objetivo desarrollar el prototipo de un instrumento para evaluar la autonomía culinaria de las mujeres. Para ello, se adoptó el modelo conceptual de autonomía culinaria y el marco teórico-metodológico de desarrollo procedimental de instrumentos. Se realizaron las siguientes etapas: identificación de manifestaciones empíricas (expresiones) del constructo de autonomía culinaria y elaboración de ítems mediante revisión de literatura, de dos grupos focales (n = 20) y de talleres de expertos (n = 25); validación de contenido y semántica de ítems mediante un panel de expertos (n = 20); evaluación de la versión preliminar del prototipo (dimensión estructural, semántica y grado de intensidad de los ítems) en un taller con especialista en desarrollo de instrumentos; y dos pretests (n = 30). La versión final del prototipo del instrumento de autonomía culinaria contiene 64 ítems y consta de dos bloques: conocimiento, hábitos y actitudes individuales, con 38 ítems; y aspectos de los hogares y prácticas de los residentes, con 26 ítems. Se está realizando un estudio a mujeres de cuatro regiones brasileñas para evaluar la validez y confiabilidad de este instrumento. La aplicación de este instrumento en diferentes realidades puede apoyar las políticas públicas de alimentación y nutrición, así como cualificar la atención nutricional en el Sistema Único de Salud brasileño.

This study aimed to develop a prototype of an instrument to assess women’s culinary autonomy. The conceptual model of culinary autonomy and the theoretical-methodological framework of procedural development of instruments were adopted for this. Steps involved finding empirical manifestations (expressions) of the construct of culinary autonomy and elaboration of items by a literature review, two focus groups (n = 20), a workshop with specialists (n = 25); content and item semantics validation by a panel of experts (n = 20); the evaluation of a preliminary version of the prototype (dimensional structure, semantics, and item intensity gradient) in a workshop with a specialist in instrument development; and two pre-tests (n = 30). The final version of the prototype of the culinary autonomy instrument contains 64 items and two blocks: individual knowledge, habits, and attitudes (38 items) and aspects of the household and residents’ practices (26 items). A study is underway to evaluate the validity and reliability of this instrument with women from four Brazilian regions. Applying this instrument in different realities can support food and nutrition public policies as well as qualify nutritional care in the Brazilian Unified National Health System.

Este estudo objetivou desenvolver o protótipo de um instrumento para avaliar a autonomia culinária de mulheres. Para isso, foram adotados o modelo conceitual de autonomia culinária e o referencial teórico-metodológico de desenvolvimento processual de instrumentos. As etapas realizadas foram: identificação de manifestações empíricas (expressões) do construto de autonomia culinária e elaboração de itens por meio de revisão da literatura, de dois grupos focais (n = 20) e de oficina de especialistas (n = 25); validação de conteúdo e semântica de itens por meio de painel de especialistas (n = 20); avaliação da versão preliminar do protótipo (estrutura dimensional, semântica e gradiente de intensidade dos itens) em oficina com especialista em desenvolvimento de instrumentos; e dois pré-testes (n = 30). A versão final do protótipo do instrumento de autonomia culinária contém 64 itens e é composta por dois blocos: conhecimentos, hábitos e atitudes individuais, com 38 itens; e aspectos do domicílio e práticas dos moradores, com 26 itens. Está em andamento estudo de avaliação da validade e da confiabilidade deste instrumento com mulheres de quatro regiões brasileiras. A aplicação desse instrumento em diferentes realidades poderá subsidiar políticas públicas de alimentação e nutrição, assim como qualificar a atenção nutricional no Sistema Único de Saúde (SUS).

https://doi.org/10.1590/0102-311xpt078924

Registro Brasileiro de Transplantes da ABTO e Registro de Transplante Cardíaco da ISHLT: Uma Valiosa Parceria
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Atik, Fernando A.

; Pego-Fernandes, Paulo Manoel

; Mejia, Juan A.

; Goldraich, Livia A.

; Marcondes-Braga, Fabiana G. Azeka, Estela Figueira, Fernando Augusto Garcia, Valter Duro Haddad, Luciana Cherikh, Wida Stehlik, Josef Cogswell, Rebecca

Arquivos Brasileiros de Cardiologia

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2025, Volume 122 N. 1 elocation e20240370

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

https://doi.org/10.36660/abc.20240370

Saturated hydraulic conductivity and steady-state infiltration rate database for Brazilian soils
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Ottoni, Marta Vasconcelos

; Teixeira, Wenceslau Geraldes

; Reis, Aline Mari Huf dos

; Pimentel, Letícia Guimarães

; Souza, Luciana Rodrigues

; Albuquerque, Jackson Adriano

; Melo, Valdinar Ferreira

; Cavalieri-Polizeli, Karina Maria Vieira

; Reichert, José Miguel

; Viana, João Herbert Moreira

; Fontana, Ademir

; Medrado, Lucas de Castro

; Santos, Glenio Guimarães

; Amaral, Luís Gustavo Henriques do

; Anjos, Lúcia Helena Cunha dos

; Araújo Filho, José Coelho de

; Bhering, Silvio Barge

; Brito, Gabrielle Fernandes de

; Valle, Pedro Gomes de Campos do

; Campos, Pablo Nieto

; Costa, Adriana Monteiro da

; Marques, Jean Dalmo de Oliveira

; Martins, Alba Leonor da Silva

; Nascimento, Michele Bruna de Souza do

; Noronha, Norberto Cornejo

; Oliveira, Ricardo Duarte de

; Portela, Jeane Cruz

; Serafim, Milson Evaldo

; Silva, Marlen Barros e

; Rodrigues, Sueli

; Almeida, Wilk Sampaio de

; Moraes, Margareth Lopes de

; Curi, Nilton

Revista Brasileira de Ciência do Solo

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2025, Volume 49 elocation e0240003

Abstract: En | Text: En | PDF: En

ABSTRACT Soil saturated hydraulic conductivity (Ksat) and steady-state infiltration rate (SSIR) are essential and necessary soil properties for different geoscience applications. Values of these hydraulic properties for the Brazilian territory are difficult to access and are dispersed in research efforts carried out around the country. This study developed an easy-to-manipulate, freely accessible database of soil saturated hydraulic conductivity, comprising field and laboratory analyses, and steady-state infiltration rates for Brazilian soils. This database was named Ksat-SSIR-DB. One analysis of the Ksat-SSIR-DB aimed to evaluate its coverage in Brazilian territory and in different soil groups. Average values of these hydraulic properties were also presented for textural classes, with values compared to those reported in international literature, and for other groupings, such as soil class, land use class, and porosity class. The variability of Ksat data in these groupings and in their combinations were also analyzed. The Ksat-SSIR-DB showed broad national coverage, comprising a total of 2,579 records, corresponding to 409 sampling sites, with Ksat and/or SSIR data and other associated soil information. A significant difference was observed between Ksat values for the vast majority of Brazilian clayey and very clayey soils compared to soils from the same textural groups from temperate regions. The two groupings that presented the lowest variability in terms of Ksat standard deviation values were the combination of textural classes with soil classes at the second category level of SiBCS (Brazilian Soil Classification System), and porosity classes with soil classes at the second category level of SiBCS. The Ksat-SSIR-DB has enormous potential for developing and testing Ksat pedotransfer functions in Brazilian soils, serving as a reference source for different geoenvironmental applications and, in particular, for modeling land surface processes. It is open access and can be accessed at https://www.sgb.gov.br/ksat-ssir-dbbase-de-dados-de-condutividade-hidraulica-saturada-e-de-taxa-de-infiltracao-basica-emsolos-brasileiros, which also includes the python script for data analysis.

https://doi.org/10.36783/18069657rbcs20240003

Chromosome spreading of the 5S rDNA clusters in the karyotype of Gymnotus inaequilabiatus (Gymnotiformes: Gymnotidae): insights into the role of the Rex-1 and Rex-3 retrotransposable elements of this process
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Gianini, Lucas Pietro Ferrari

; Balini, Ligia Carla

; Porto, Fernanda Errero

; Borin-Carvalho, Luciana Andreia

; Fernandes, Carlos Alexandre

Neotropical Ichthyology

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2025, Volume 23 N. 1 elocation e240089

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Gymnotus inaequilabiatus tem sido objeto de poucos estudos sobre a organização de suas estruturas macro e microcariotípicas. Este artigo tem como objetivo aprimorar os dados citogenéticos existentes para G. inaequilabiatus da bacia do alto rio Paraná documentando seu cariótipo e outras características cromossômicas, incluindo DNA ribossômico (rDNA) e os retroelementos Rex-1e Rex-3, que ainda não foram descritos para este gênero. O número diploide modal de 2n = 54, distribuído em 34m + 18sm +2a para ambos os sexos, foi observado. Regiões organizadoras nucleolares únicas (NORs) foram detectadas em um par de cromossomos metacêntricos (1º) e confirmadas por hibridização in situ por fluorescência (FISH) com as sondas DNAr 18S. Multiplos sítios de DNAr 5S foram detectados em 31 cromossomos, principalmente nas regiões pericentroméricas. A heterocromatina foi detectada nas regiões centroméricas e pericentroméricas de todos os cromossomos e intercalada em NORs. Os elementos Rex-1 e Rex-3 exibiram padrões de dispersão semelhantes, caracterizados por pequenos aglomerados espalhados pelos cromossomos em regiões eucromáticas e heterocromáticas. Além disso, a disseminação dos sinais Rex-1 e Rex-3 em adjacências dos sítios 5S rDNA pode refletir seu papel na dispersão dessas regiões. Os dados presentes são valiosos para ajudar a entender a evolução cariotípica em G. inaequilabiatus.

Abstract Gymnotus inaequilabiatus has been the subject of few studies concerning the organization of its macro- and micro-karyotypic structures. This article aims to enhance the existing cytogenetic data for G. inaequilabiatus from the upper Paraná River basin by documenting its karyotype and other chromosomal characteristics, including ribosomal DNA (rDNA) and the retroelements Rex-1 and Rex-3, which have yet to be described for this genus. The modal diploid number of 2n = 54, distributed in 34m + 18sm +2a for both sexes, was observed. Single nucleolar organizing regions (NORs) were detected on a metacentric chromosome pair (1st) and confirmed by fluorescence in situ hybridization (FISH) with the 18S rDNA probes. Multiple 5S rDNA sites were detected on 31 chromosomes, mainly in the pericentromeric regions. Heterochromatin was detected at centromeric and pericentromeric regions of all chromosomes and interspersed to NORs. The Rex-1 and Rex-3 elements displayed similar dispersion patterns, characterized by small clusters spread throughout the chromosomes in both euchromatic and heterochromatic regions. Besides, the spreading of Rex-1 and Rex-3 signals in adjacencies of the 5S rDNA sites could reflect their role in the dispersion of these regions. The present data are valuable in helping to understand karyotypic evolution in G. inaequilabiatus.

https://doi.org/10.1590/1982-0224-2024-0089

An institutional COVID-19 initiative: creation of a biobank and serological data analysis in pre- and post-vaccination cohorts
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FERNANDES-SIQUEIRA, LORENA O.

; MELO, RAPHAEL R.A.

; WERMELINGER, LUCIANA S.

; ALMEIDA, FABIO C.L.

; SALMON, DIDIER

; FERREIRA, GUSTAVO C.

; DA POIAN, ANDREA T.

Anais da Academia Brasileira de Ciências

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2025, Volume 97 N. 1 elocation e20240819

Abstract: En | Text: En | PDF: En

Abstract The COVID-19 pandemic has left a legacy in the management of health emergencies, but sentinel surveillance was relatively underused, despite its significant role in decision-making during epidemics. Here we describe a sentinel surveillance for anti-SARS-CoV-2 serology carried out on a cohort of 395 individuals at a Brazilian institution, from October 2020 to December 2022. A total of 1,507 serum samples were analyzed for IgG and IgA against SARS-CoV-2 Spike (S) or nucleocapsid (N) proteins, in the pre- and post-vaccination periods. The latter included two doses of CoronaVac (group 1, G1), or ChAdOx-1 or BNT162b2 (group 2, G2), followed by heterologous booster doses. In the pre-vaccination phase, 26.5% of the participants showed IgG reactivity for S and 13.7% for N. After the vaccines’ first dose, S IgG response was positive in 66.6% or 98% of G1 or G2 participants, respectively, whereas 100% of the participants showed S IgG positivity after the second dose, and S IgG and IgA after the booster. This initiative enabled the examination of viral transmission beyond hospital environments, which has rarely been explored, and established protocols for managing future emergencies. In addition, a serum bank and a comprehensive database are now available to the scientific community.

https://doi.org/10.1590/0001-3765202520240819

Plantago major leaf extract against bacteria and fungi of medical importance
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Sousa, Débora Silva Marques de

; Ruiz, Luciana da Silva

; Pereira, Ana Flávia Marques

; Sani, Alessandra Aguirra

; Zapata, Tatiane Baptista

; Monari, Gabrielle Pires de Morais

; Rosa, Cassiana Ferreira da

; Fernandes Junior, Ary

; Rall, Vera Lucia Mores

; Prado, Diego Godina

; Oliveira, Alberto de

; Bosco, Sandra de Moraes Gimenes

Brazilian Journal of Pharmaceutical Sciences

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2025, Volume 61 elocation e24143

Abstract: En | Text: En | PDF: En

Abstract Antimicrobial drug resistance is a challenge to public health. Various microorganisms, including methicillin-resistant Staphylococcus aureus (MRSA), Pseudomonas aeruginosa, carbapenemase-producing Klebsiella pneumoniae, Pythium insidiosum, and Candida auris, have developed resistance to commonly used antimicrobials in infection disease treatments. Consequently, there is an urgent need to explore and develop novel therapeutic drugs. Natural products, particularly medicinal plants, have received attention in the quest for innovative treatments for various diseases. Plantago major is a plant endowed with several biological properties, such as antibacterial, antifungal, and healing actions. This study aimed to investigate the antimicrobial activities of the methanolic extract obtained from the leaves of P. major. Microdilution assays were conducted to determine the minimum inhibitory concentration and minimum bactericidal and fungicidal concentration. Additionally, synergism with antimicrobial drugs was assessed using a time-kill curve analysis. A synergistic bactericidal interaction between the extract and imipenem was observed against carbapenemase-producing K. pneumoniae. For MRSA, a bacteriostatic synergism was noted in combinations of the extract with cephalotin and oxacillin. For C. auris, a fungistatic interaction was observed between the extract and amphotericin B. These results suggest the presence of bioactive compounds within the extract with therapeutic potential for combating infections caused by these microorganisms.

https://doi.org/10.1590/s2175-97902025e24143

Anais Brasileiros de Dermatologia: 100 years of history (1925-2025)
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Marques, Sílvio Alencar

; Roselino, Ana Maria Ferreira

; Almeida Junior, Hiram Larangeira de

; Abbade, Luciana Patrícia Fernandes

Anais Brasileiros de Dermatologia

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2025, Volume 100 N. 1 elocation 202408001

Abstract: En | Text: En | PDF: En

Abstract The month of January 1925 marks the birth of the Annaes Brasileiros de Dermatologia e Syphilografia and currently, 100 years later, with great merit, we celebrate its evolution into Anais Brasileiros de Dermatologia (ABD). Indeed, those few brilliant pioneers never dreamed of the strength of the Brazilian Society of Dermatology nowadays. However, perhaps they envisioned a relevant role for ABD, with a natural space for dermatoses of infectious etiology, always prevalent in tropical and subtropical regions. And thus, it was established for decades. Currently, Brazilian Dermatology and ABD are plural and open to the different facets of Dermatology. However, both the specialty, Dermatology, and its official body, ABD, value and pay homage to history, and cannot forget or stray from it. Numerous challenges have been faced over the past 100 years. Many other challenges still remain, but it is up to us, as a gift to the 100th anniversary of the Anais Brasileiros de Dermatologia, to learn about them and reflect on them. The following text provides a summary of the history of ABD over the years. We invite national and international readers to celebrate with us.

https://doi.org/10.1016/j.abd.2024.08.001

10.

Prevalence of positivity in patch tests and reactivity to substances present in the main dressings in patients with chronic leg ulcers
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Mesquita, Ísis Fiorello de Oliveira

; Fonseca, Larissa Pierri Carvalho

; Fortes, Maria Rita Parise

; Miot, Hélio Amante

; Abbade, Luciana Patricia Fernandes

Anais Brasileiros de Dermatologia

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2025, Volume 100 N. 1 elocation 202405003

Abstract: En | Text: En | PDF: En

https://doi.org/10.1016/j.abd.2024.05.003

11.

Outbreak of monensin poisoning in equines: clinical signs, histopathologic findings and chromatographic diagnosis
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Correia, Nelcimara Mirley de Souza

; Fernandes, Wagner Luís

; Lana, Mary Ane Gonçalves

; Moraes, Isadora David Tavares de

; Nunes, Julia Paiva

; Ferreira, Jéssyca Ataíde

; Vicente, Monica Chacon de

; Barros, Alexandre Có Mangoni

; Guimarães, Ana Rita Rodrigues

; Souza, Murilo Rodrigues de

; Miranda, Ana Luísa Soares de

; Miguel, Marina Pacheco

; Queiroz, Paulo José Bastos

; Martins, Danieli Brolo

; Franco, Leandro Guimarães Brandstetter, Luciana Ramos Gaston Botelho, Ana Flávia Machado

Ciência Rural

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2025, Volume 55 N. 6 elocation e20240196

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO: Ionóforos são antibióticos poliéteres utilizados na produção animal para ruminantes e aves para promover o crescimento e exercer ação coccidiostática. Apesar dos benefícios de seu uso, intoxicações também foram relatadas em diversas espécies. Os equídeos são muito sensíveis e a maioria dos casos envolve ingestão inadequada de alimentos destinados a ruminantes. Este trabalho descreve um surto de intoxicação por ionóforo em sete cavalos e um burro que ingeriram concentrado de gado, confirmado por método de diagnóstico inovador. Um cavalo de seis anos de idade apresentou sinais clínicos de sialorreia, sudorese, ataxia, prostração, anorexia, tremores musculares, decúbito lateral, decúbito lateral, iniciados no dia anterior. Foram realizados exames laboratoriais e eletrocardiograma, que evidenciaram aumento da atividade de AST e CK, além de taquicardia ventricular. Devido à gravidade do quadro, o paciente foi eutanasiado no dia da internação, sendo realizada necropsia, na qual foram examinados tecidos musculares esqueléticos e cardíacos. A histologia revelou necrose multifocal em cardiomiócitos, necrose, edema e hemorragia no músculo esquelético. Foi realizada visita à propriedade para avaliação de outros animais e coleta de amostras para exames laboratoriais. Todos os cinco animais restantes foram submetidos a exame físico, dois dos quais apresentaram sinais clínicos graves. Três animais apresentaram anemia normocítica normocrômica, quatro apresentaram aumento da creatinina, dois apresentaram aumento de atividade de AST e todos apresentaram aumento de atividade de CK. Entre os demais animais intoxicados, dois morreram na propriedade. A amostra de fígado do primeiro cavalo eutanasiado foi examinada por cromatografia líquida acoplada à espectrometria de massa, identificando 51,59 µg/kg de monensina. Conclui-se que, apesar da recuperação dos animais, a ação tóxica do ionóforo pode causar lesões que afetam a saúde e o bem-estar do animal. A viabilidade da análise cromatográfica é essencial para um diagnóstico definitivo e deve ser posteriormente desenvolvida juntamente com valores de referência para resíduos teciduais e limite máximo tolerável.

ABSTRACT: Ionophores are polyether antibiotics used in animal production for ruminants and birds to promote growth and exert coccidiostat action. Despite the benefits of their use, poisonings have also been reported in several species. Equines are very sensitive, and most cases involve mistaken intake of feed intended for ruminants. This research described an outbreak of ionophore poisoning in seven horses and a mule that ingested livestock concentrate, confirmed by a chromatographic diagnostic method. A six-year-old horse was presented with clinical signs of sialorrhea, sweating, ataxia, prostration, anorexia, muscle tremors, lateral recumbency, posterior lateral decubitus, which began the day before. Laboratory tests showed increased AST (aspartate aminotransferase) and CK (creatine kinase) activities. Electrocardiogram revealed ventricular tachycardia. Due to the severity of the condition, the patient was euthanized on the day of admission, and a necropsy was performed, in which skeletal and cardiac muscle tissues were collected. Histology revealed multifocal necrosis in cardiomyocytes, necrosis, edema and hemorrhage in skeletal muscle. A visit was made to the property to evaluate other animals and collect samples for laboratory tests. All remaining animals underwent physical examination, two of which showed serious clinical signs. Three animals showed normocytic normochromic anemia, four increased creatinine, two had increased AST activity and all had increased CK activity. Among the poisoned animals, two died on the property. Liver sample from the first euthanized horse was examined by liquid chromatography coupled with mass spectrometry, identifying 51.59 µg/kg of monensin. It is concluded that, despite the recovery of the animals, the toxic action of the ionophore can cause injuries that affect equine health and welfare. The feasibility of chromatographic analysis is essential for a definitive diagnosis and must be subsequently developed together with reference values for tissue residues and maximum tolerated doses.

https://doi.org/10.1590/0103-8478cr20240196

12.

Desenvolvimento de protótipo de instrumento para aferir autonomia culinária de mulheres
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Maldonado, Luciana

; Oliveira, Mariana Fernandes Brito de

; Castro, Inês Rugani Ribeiro de

Cadernos de Saúde Pública

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2025, Volume 41 N. 2 elocation e00078924

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

https://doi.org/10.1590/0102-311xpt078924

13.

Interrelationships of frailty, hemoglobin, cognition, and depressive symptoms in aging: a path analysis of the ELSI-Brazil study
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Corona, Ligiana Pires

; Oliveira, Gabriela Benatti de

; Fernandes, Lara Vilar

; Ramos, Natalie Bitencourt

; Freiria, Carolina Neves

; Costa, Luciana Scarlazzari

Cadernos de Saúde Pública

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2025, Volume 41 N. 3 elocation e00105124

Abstract: Pt Es En | Text: Pt Es En | PDF: Pt | PDF: Es | PDF: En

Este estudo objetivou avaliar as inter-relações entre anemia, depressão e cognição, bem como alguns de seus fatores associados, para compreender os caminhos até a fragilidade. Foram utilizados dados de 2.174 participantes da linha de base do Estudo Longitudinal de Saúde dos Idosos Brasileiros (ELSI-Brasil). Utilizou-se análise de caminhos para avaliar as relações entre variáveis exógenas (local de residência, escolaridade, número de doenças, escore de alimentação e número de dentes naturais), uma endógena (fragilidade) e três mediadoras (cognição, depressão e nível de hemoglobina). Nas análises, cognição e hemoglobina tiveram caminho negativo para fragilidade, e sintomas depressivos, positivo. Entre as variáveis exógenas, zona rural teve efeito negativo sobre hemoglobina, sintomas depressivos e fragilidade; maior escolaridade apresentou caminho positivo para cognição; número de doenças teve caminho negativo para hemoglobina, e positivo para sintomas depressivos e fragilidade; escore de alimentação apresentou caminho negativo para hemoglobina e sintomas depressivos; número de dentes teve efeito positivo na cognição e hemoglobina, e negativo na fragilidade. Dois caminhos sem efeito direto tiveram efeitos indiretos significativos - zona rural apresentou relação indireta com cognição via hemoglobina e sintomas depressivos; e escolaridade teve caminho indireto para fragilidade, mediado pelas três variáveis intermediárias. Esses resultados mostram complexas inter-relações entre fragilidade, hemoglobina, cognição e sintomas depressivos, importantes para compreender a síndrome de maneira ampla, de modo que se possa planejar medidas mais abrangentes de prevenção e intervenção.

Este estudio tuvo como objetivo evaluar las interrelaciones entre la anemia, la depresión y la cognición, así como algunos de sus factores asociados, para comprender las trayectorias hacia la fragilidad. Se utilizaron datos de 2.174 participantes de la línea de base del Estudio Longitudinal sobre la Salud de Ancianos Brasileños (ELSI-Brasil). El análisis de la trayectoria se utilizó para evaluar las relaciones entre las variables exógenas (lugar de residencia, nivel de estudios, número de enfermedades, puntuación de alimentación y número de dientes naturales), una endógena (fragilidad) y tres mediadores (cognición, depresión y nivel de hemoglobina). Los análisis mostraron que la cognición y la hemoglobina tuvieron una trayectoria negativa para fragilidad; y que los síntomas depresivos presentaron una trayectoria positiva. Entre las variables exógenas, las áreas rurales tuvieron un efecto negativo sobre la hemoglobina, los síntomas depresivos y la fragilidad; mayor nivel de estudios tuvo una trayectoria positiva para la cognición; el número de enfermedades tuvo una trayectoria negativa para la hemoglobina, y positiva para los síntomas depresivos y la fragilidad; la puntuación de alimentos tuvo una trayectoria negativa para la hemoglobina y los síntomas depresivos; el número de dientes tuvo un efecto positivo sobre la cognición y la hemoglobina; y negativo sobre la fragilidad. Dos trayectorias sin efecto directo tuvieron efectos indirectos significativos: las áreas rurales mostraron una relación indirecta con la cognición a través de la hemoglobina y los síntomas depresivos; y el nivel de estudios tuvo una trayectoria indirecta para fragilidad mediada por las tres variables intermedias. Estos resultados muestran interrelaciones complejas entre la fragilidad, la hemoglobina, la cognición y los síntomas depresivos, elementos importantes para comprender el síndrome de una manera amplia, de modo que se puedan promover medidas de prevención e intervención más integrales.

This study analyzed the interrelationships of anemia, depression, and cognition, as well as some of their associated factors to understand the paths to frailty. Data from 2,174 baseline participants of the Brazilian Longitudinal Study of Aging (ELSI-Brazil) were used. Path analysis was used to assess the relationships of exogenous variables (place of residence, education level, number of diseases, diet score, and number of natural teeth), one endogenous variable (frailty), and three mediators (cognition, depression, and hemoglobin level). Cognition and hemoglobin level showed a negative path to frailty, while depressive symptoms showed a positive path. Among the exogenous variables, rural area had a negative effect on hemoglobin, depressive symptoms, and frailty; a higher education level showed a positive path to cognition; number of diseases showed a negative path to hemoglobin and a positive path to depressive symptoms and frailty; diet score showed a negative path to hemoglobin and depressive symptoms; number of teeth had a positive effect on cognition and hemoglobin and a negative effect on frailty. Two paths without direct effects had significant indirect effects - rural area showed an indirect relationship with cognition via hemoglobin and depressive symptoms; and education level showed an indirect path to frailty, mediated by the three intermediate variables. These results show complex interrelationships of frailty, hemoglobin, cognition, and depressive symptoms, which help understand the syndrome in a broad way and support the planning of more comprehensive prevention and intervention measures.

https://doi.org/10.1590/0102-311xen105124

14.

Interrelationships of frailty, hemoglobin, cognition, and depressive symptoms in aging: a path analysis of the ELSI-Brazil study
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Corona, Ligiana Pires

; Oliveira, Gabriela Benatti de

; Fernandes, Lara Vilar

; Ramos, Natalie Bitencourt

; Freiria, Carolina Neves

; Costa, Luciana Scarlazzari

Cadernos de Saúde Pública

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2025, Volume 41 N. 3 elocation e00105124

Abstract: En Pt Es | Text: En Pt Es | PDF: En | PDF: Pt | PDF: Es

https://doi.org/10.1590/0102-311xen105124

15.

Livedoid vasculopathy, calciphylaxis, and Martorell’s hypertensive ulcer: update on ischemic ulcers due to impaired microcirculation of the lower limbs
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Lacerda, Priscila Neri

; Garcia, Lucas Campos

; Mazeto, Izabelle Ferreira da Silva

; Miot, Hélio Amante

; Abbade, Luciana Patricia Fernandes

Anais Brasileiros de Dermatologia

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2025, Volume 100 N. 2 elocation 202409004

Abstract: En | Text: En | PDF: En

Abstract Ischemic ulcers due to compromised microcirculation of the lower limbs cause painful ulcers that represent a challenge for the correct diagnosis and treatment. Livedoid vasculopathy, calciphylaxis, and Martorell’s hypertensive ischemic ulcer are part of this group and present some similarities due to microvascular occlusive impairment. They are often misdiagnosed as inflammatory ulcers such as pyoderma gangrenosum and vasculitis. This review discusses the pathophysiology, risk factors, clinical aspects, differential diagnoses, histopathology, and presents a therapeutic update of livedoid vasculopathy, calciphylaxis, and Martorell’s ulcer. Although they are less frequent causes of chronic ulcers, a correct diagnosis is essential to reduce the chance of erroneous therapies that may impact morbidity and mortality related to these conditions.

https://doi.org/10.1016/j.abd.2024.09.004

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